ViRBase ID Virus Host Species ncRNA Source ncRNA Category ncRNA Symbol ncRNA Link Tissue Expression Direction of ncRNA Interactor Source Interactor Category Interactor Symbol Interactor Link Expression Direction of Interactor Detection Method PMID Description VHID00000001 Adenovirus(ADV) Homo sapiens Virus LncRNA VAI http://lncrnadb.com/Detail.aspx?TKeyID=231 - - Host Protein Ago2 http://www.ncbi.nlm.nih.gov/gene/27161 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00000002 Adenovirus(ADV) Homo sapiens Virus LncRNA VAI http://lncrnadb.com/Detail.aspx?TKeyID=231 - - Host Protein DICER http://www.ncbi.nlm.nih.gov/gene/23405 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00000003 Adenovirus(ADV) Homo sapiens Virus LncRNA VAI http://lncrnadb.com/Detail.aspx?TKeyID=231 - - Host Protein EIF2AK2(PKR) http://www.ncbi.nlm.nih.gov/gene/5610 Downregulation U.V.-crosslinking and gel electrophoresis, peptide phosphorylation assay, Filter binding assays. 7901835 The interferon-inducible protein kinase PKR interacts with a number of small viral RNA species, including adenovirus VAI RNA and the Epstein-Barr virus-encoded RNA EBER-1.Using a peptide phosphorylation assay we show here that EBER-1, like VAI, directly inhibits the activation of purified PKR. A second Epstein-Barr virus RNA, EBER-2, also regulates PKR. EBER-1, EBER-2 and VAI RNA exhibit mutually competitive binding to the native or recombinant enzyme, as assessed by U.V. crosslinking experiments and filter binding assays. . VHID00000004 Adenovirus(ADV) Homo sapiens Virus LncRNA VAI http://lncrnadb.com/Detail.aspx?TKeyID=231 - - Host Protein La http://www.ncbi.nlm.nih.gov/gene/6741 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00000005 Adenovirus(ADV) Homo sapiens Virus LncRNA VAI http://lncrnadb.com/Detail.aspx?TKeyID=231 - - Host Protein PKR http://www.ncbi.nlm.nih.gov/gene/5610 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00000006 Adenovirus(ADV) Homo sapiens Virus LncRNA VAI http://lncrnadb.com/Detail.aspx?TKeyID=231 - - Host Protein PKR http://www.ncbi.nlm.nih.gov/gene/5610 - PKR autophosphorylation inhibition assays,RNA secondary structure probing, RNA UV-melting analysis. 19635730 The relative ability of the two apical stem conformations to bind PKR and inhibit kinase activity was measured by isothermal titration calorimetry and PKR autophosphorylation inhibition assay.Whether the presence of the VA RNA(I) conformation with reduced PKR inhibitory activity is directly beneficial to the virus in the cell for some other function requires further investigation. VHID00000007 Adenovirus(ADV) Homo sapiens Virus LncRNA VAII http://lncrnadb.com/Detail.aspx?TKeyID=231 - - Host Protein Ago2 http://www.ncbi.nlm.nih.gov/gene/27161 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00000008 Adenovirus(ADV) Homo sapiens Virus LncRNA VAII http://lncrnadb.com/Detail.aspx?TKeyID=231 - - Host Protein DICER http://www.ncbi.nlm.nih.gov/gene/23405 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00000009 Adenovirus(ADV) Homo sapiens Virus LncRNA VAII http://lncrnadb.com/Detail.aspx?TKeyID=231 - - Host Protein La http://www.ncbi.nlm.nih.gov/gene/6741 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00000010 Bombyx mori nuclearpolyhedrosis virus(BmNPV) Bombyx mori Virus miRNA bmnpv-miR-1 # HeLa cells - Host Protein Ran # Downregulation Northern blot analysis/Western blot assay. 22593162 We demonstrate that an insect virus, Bombyx mori nucleopolyhedrosis virus(BmNPV), modulates the small-RNA-mediated defense of its host, B. mori, by encoding an miRNA(bmnpv-miR-1) that downregulates the expression of the host GTP-binding nuclear protein Ran, an essential component of the exportin-5-mediated nucleocytoplasmic transport machinery mainly involved in small-RNA transport from the nucleus to the cytoplasm. VHID00000011 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER1 http://lncrnadb.com/Detail.aspx?TKeyID=224 - - Host Protein EIF2AK2(PKR) http://www.ncbi.nlm.nih.gov/gene/5610 Downregulation U.V.-crosslinking and gel electrophoresis, peptide phosphorylation assay, Filter binding assays. 7901835 The interferon-inducible protein kinase PKR interacts with a number of small viral RNA species, including adenovirus VAI RNA and the Epstein-Barr virus-encoded RNA EBER-1.Using a peptide phosphorylation assay we show here that EBER-1, like VAI, directly inhibits the activation of purified PKR. A second Epstein-Barr virus RNA, EBER-2, also regulates PKR. EBER-1, EBER-2 and VAI RNA exhibit mutually competitive binding to the native or recombinant enzyme, as assessed by U.V. crosslinking experiments and filter binding assays. . VHID00000012 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER1 http://lncrnadb.com/Detail.aspx?TKeyID=224 - - Host Protein L22 http://www.ncbi.nlm.nih.gov/gene/28892 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00000013 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER1 http://lncrnadb.com/Detail.aspx?TKeyID=224 - - Host Protein La http://www.ncbi.nlm.nih.gov/gene/6741 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00000014 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER1 http://lncrnadb.com/Detail.aspx?TKeyID=224 - - Host Protein PKR http://www.ncbi.nlm.nih.gov/gene/5610 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00000015 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER1 http://lncrnadb.com/Detail.aspx?TKeyID=224 - - Host Protein PKR http://www.ncbi.nlm.nih.gov/gene/5610 Downregulation - 20399962 EBERs have been discovered to interact with cellular proteins that play a key role in antiviral innate immunity. They bind the protein kinase RNA-dependent (PKR) and inhibit its activation, leading to resistance to PKR-mediated apoptosis. VHID00000016 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER1 http://lncrnadb.com/Detail.aspx?TKeyID=224 - - Host Protein RIG-I http://www.ncbi.nlm.nih.gov/gene/23586 Downregulation - 20399962 Previous studies demonstrated that EBERs (EBER1 and EBER2) play significant roles in various EBV-infected cancer cells. EBERs induce the expression of interleukin(IL)-10 in BL cells, insulin-like growth factor(IGF)-1 in gastric carcinoma and nasopharyngeal carcinoma cells, IL-9 in T cells that act as an autocrine growth factor. It was also reported that EBERs play critical roles in the B cell growth transformation including IL-6 induction by EBER2.Recently, it was demonstrated that EBERs bind RIG-I and activate its downstream signaling, which induces expression of type-I interferon (IFN)s. VHID00000017 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER1 http://lncrnadb.com/Detail.aspx?TKeyID=224 - - Host Protein TLR-3 http://www.ncbi.nlm.nih.gov/gene/7098 - - 20399962 Most recently, it was reported that EBERs are secreted from EBV-infected cells and are recognized by toll-like receptor (TLR)3, leading to induction of type-I IFNs and inflammatory cytokines, and subsequent immune activation. Furthermore, EBER1 could be detected in the sera of patients with active EBV infectious diseases, suggesting that activation of TLR3 signaling by EBER1 would be account for the pathogenesis of active EBV infectious diseases. VHID00000018 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER1 http://lncrnadb.com/Detail.aspx?TKeyID=224 B cells - Host Protein RPL22(L22) http://www.ncbi.nlm.nih.gov/gene/6146 - Electrophoretic mobility-shift assays(EMSAs). 16556938 Multiple domains of EBER 1, an Epstein-Barr virus noncoding RNA, recruit human ribosomal protein L22. Here we present in vitro binding studies using purified RNAs and recombinant proteins. Electrophoretic mobility-shift assays(EMSAs) show that recombinant L22(rL22) and maltose-binding protein(MBP)-tagged L22 protein bind EBER 1 in vitro, both forming three specific protein-dependent mobility shifts. VHID00000019 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER1 http://lncrnadb.com/Detail.aspx?TKeyID=224 B lymphocytes - Host Protein SSB(La) http://www.ncbi.nlm.nih.gov/gene/6741 - Hybridization analyses. 6262773 Hybridization analyses indicate that EBER 1 and EBER 2 are encoded by the EcoRI-J fragment of EBV(B95-8) DNA. In vivo both RNAs are associated with protein(s), allowing their specific precipitation by the systemic lupus erythematosus-associated antibody anti-La. VHID00000020 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER1 http://lncrnadb.com/Detail.aspx?TKeyID=224 BL cells - Host Protein IL-10 http://www.ncbi.nlm.nih.gov/gene/3586 Downregulation - 20399962 Previous studies demonstrated that EBERs (EBER1 and EBER2) play significant roles in various EBV-infected cancer cells. EBERs induce the expression of interleukin(IL)-10 in BL cells, insulin-like growth factor(IGF)-1 in gastric carcinoma and nasopharyngeal carcinoma cells, IL-9 in T cells that act as an autocrine growth factor. It was also reported that EBERs play critical roles in the B cell growth transformation including IL-6 induction by EBER2. VHID00000021 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER1 http://lncrnadb.com/Detail.aspx?TKeyID=224 Gastric carcinoma and nasopharyngeal carcinoma cells - Host Protein IGF-1 http://www.ncbi.nlm.nih.gov/gene/3479 Downregulation - 20399962 Previous studies demonstrated that EBERs (EBER1 and EBER2) play significant roles in various EBV-infected cancer cells. EBERs induce the expression of interleukin(IL)-10 in BL cells, insulin-like growth factor(IGF)-1 in gastric carcinoma and nasopharyngeal carcinoma cells, IL-9 in T cells that act as an autocrine growth factor. It was also reported that EBERs play critical roles in the B cell growth transformation including IL-6 induction by EBER2. VHID00000022 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER1 http://lncrnadb.com/Detail.aspx?TKeyID=224 Human B lymphocytes - Host Protein RPL22(L22) http://www.ncbi.nlm.nih.gov/gene/6146 - Situ hybridization, Two-Dimensional (2-D) Gel Electrophoresis, Immunofluorescence. 8159770 The Epstein-Barr virus (EBV) small RNA EBER1 binds and relocalizes ribosomal protein L22 in EBV-infected human B lymphocytes. In situ hybridization indicates that the EBER RNPs are predominantly nucleoplasmic, suggesting that L22 relocalization correlates with binding to EBER1 in vivo. VHID00000023 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER1 http://lncrnadb.com/Detail.aspx?TKeyID=224 T cells - Host Protein IL-9 http://www.ncbi.nlm.nih.gov/gene/3578 Downregulation - 20399962 Previous studies demonstrated that EBERs (EBER1 and EBER2) play significant roles in various EBV-infected cancer cells. EBERs induce the expression of interleukin(IL)-10 in BL cells, insulin-like growth factor(IGF)-1 in gastric carcinoma and nasopharyngeal carcinoma cells, IL-9 in T cells that act as an autocrine growth factor. It was also reported that EBERs play critical roles in the B cell growth transformation including IL-6 induction by EBER2. VHID00000024 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER2 http://lncrnadb.com/Detail.aspx?TKeyID=224 - - Host Protein EIF2AK2(PKR) http://www.ncbi.nlm.nih.gov/gene/5610 Downregulation U.V.-crosslinking and gel electrophoresis, Peptide phosphorylation assay, Filter binding assays. 7901835 The interferon-inducible protein kinase PKR interacts with a number of small viral RNA species, including adenovirus VAI RNA and the Epstein-Barr virus-encoded RNA EBER-1. Using a peptide phosphorylation assay we show here that EBER-1, like VAI, directly inhibits the activation of purified PKR. A second Epstein-Barr virus RNA, EBER-2, also regulates PKR. . VHID00000025 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER2 http://lncrnadb.com/Detail.aspx?TKeyID=224 - - Host Protein La http://www.ncbi.nlm.nih.gov/gene/6741 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00000026 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER2 http://lncrnadb.com/Detail.aspx?TKeyID=224 - - Host Protein Nucleolin http://www.ncbi.nlm.nih.gov/gene/4691 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00000027 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER2 http://lncrnadb.com/Detail.aspx?TKeyID=224 - - Host Protein PKR http://www.ncbi.nlm.nih.gov/gene/5610 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00000028 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER2 http://lncrnadb.com/Detail.aspx?TKeyID=224 - - Host Protein PKR http://www.ncbi.nlm.nih.gov/gene/5610 Downregulation - 20399962 EBERs have been discovered to interact with cellular proteins that play a key role in antiviral innate immunity. They bind the protein kinase RNA-dependent (PKR) and inhibit its activation, leading to resistance to PKR-mediated apoptosis. VHID00000029 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER2 http://lncrnadb.com/Detail.aspx?TKeyID=224 - - Host Protein RIG-I http://www.ncbi.nlm.nih.gov/gene/23586 Downregulation - 20399962 Previous studies demonstrated that EBERs (EBER1 and EBER2) play significant roles in various EBV-infected cancer cells. EBERs induce the expression of interleukin(IL)-10 in BL cells, insulin-like growth factor(IGF)-1 in gastric carcinoma and nasopharyngeal carcinoma cells, IL-9 in T cells that act as an autocrine growth factor. It was also reported that EBERs play critical roles in the B cell growth transformation including IL-6 induction by EBER2.Recently, it was demonstrated that EBERs bind RIG-I and activate its downstream signaling, which induces expression of type-I interferon (IFN)s. VHID00000030 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER2 http://lncrnadb.com/Detail.aspx?TKeyID=224 - - Host Protein TLR-3 http://www.ncbi.nlm.nih.gov/gene/7098 - - 20399962 Most recently, it was reported that EBERs are secreted from EBV-infected cells and are recognized by toll-like receptor (TLR)3, leading to induction of type-I IFNs and inflammatory cytokines, and subsequent immune activation. . VHID00000031 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER2 http://lncrnadb.com/Detail.aspx?TKeyID=224 B cells - Host Protein IL-6 http://www.ncbi.nlm.nih.gov/gene/3569 Downregulation - 20399962 Previous studies demonstrated that EBERs (EBER1 and EBER2) play significant roles in various EBV-infected cancer cells. EBERs induce the expression of interleukin(IL)-10 in BL cells, insulin-like growth factor(IGF)-1 in gastric carcinoma and nasopharyngeal carcinoma cells, IL-9 in T cells that act as an autocrine growth factor. It was also reported that EBERs play critical roles in the B cell growth transformation including IL-6 induction by EBER2. VHID00000032 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER2 http://lncrnadb.com/Detail.aspx?TKeyID=224 B lymphocytes - Host Protein SSB(La) http://www.ncbi.nlm.nih.gov/gene/6741 - Hybridization analyses. 6262773 Hybridization analyses indicate that EBER 1 and EBER 2 are encoded by the EcoRI-J fragment of EBV(B95-8) DNA. In vivo both RNAs are associated with protein(s), allowing their specific precipitation by the systemic lupus erythematosus-associated antibody anti-La. VHID00000033 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER2 http://lncrnadb.com/Detail.aspx?TKeyID=224 BL cells - Host Protein IL-10 http://www.ncbi.nlm.nih.gov/gene/3586 Downregulation - 20399962 Previous studies demonstrated that EBERs (EBER1 and EBER2) play significant roles in various EBV-infected cancer cells. EBERs induce the expression of interleukin(IL)-10 in BL cells, insulin-like growth factor(IGF)-1 in gastric carcinoma and nasopharyngeal carcinoma cells, IL-9 in T cells that act as an autocrine growth factor. It was also reported that EBERs play critical roles in the B cell growth transformation including IL-6 induction by EBER2. VHID00000034 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER2 http://lncrnadb.com/Detail.aspx?TKeyID=224 Gastric carcinoma and nasopharyngeal carcinoma cells - Host Protein IGF-1 http://www.ncbi.nlm.nih.gov/gene/3479 Downregulation - 20399962 Previous studies demonstrated that EBERs (EBER1 and EBER2) play significant roles in various EBV-infected cancer cells. EBERs induce the expression of interleukin(IL)-10 in BL cells, insulin-like growth factor(IGF)-1 in gastric carcinoma and nasopharyngeal carcinoma cells, IL-9 in T cells that act as an autocrine growth factor. It was also reported that EBERs play critical roles in the B cell growth transformation including IL-6 induction by EBER2. VHID00000035 Epstein-Barr virus(EBV) Homo sapiens Virus LncRNA EBER2 http://lncrnadb.com/Detail.aspx?TKeyID=224 T cells - Host Protein IL-9 http://www.ncbi.nlm.nih.gov/gene/3578 Downregulation - 20399962 Previous studies demonstrated that EBERs (EBER1 and EBER2) play significant roles in various EBV-infected cancer cells. EBERs induce the expression of interleukin(IL)-10 in BL cells, insulin-like growth factor(IGF)-1 in gastric carcinoma and nasopharyngeal carcinoma cells, IL-9 in T cells that act as an autocrine growth factor. It was also reported that EBERs play critical roles in the B cell growth transformation including IL-6 induction by EBER2. VHID00000036 Epstein-Barr virus(EBV) Homo sapiens Virus SnoRNA v-snoRNA1 # - - Host Protein Fibrillarin http://www.ncbi.nlm.nih.gov/gene/2091 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00000037 Epstein-Barr virus(EBV) Homo sapiens Virus SnoRNA v-snoRNA1 # - - Host Protein Nop56 http://www.ncbi.nlm.nih.gov/gene/10528 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00000038 Epstein-Barr virus(EBV) Homo sapiens Virus SnoRNA v-snoRNA1 # - - Host Protein Nop58 http://www.ncbi.nlm.nih.gov/gene/51602 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00000039 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA ALS2 http://www.ncbi.nlm.nih.gov/gene/57679 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000040 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA AMMECR1 http://www.ncbi.nlm.nih.gov/gene/9949 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000041 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA AMMECR1L http://www.ncbi.nlm.nih.gov/gene/83607 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000042 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA ANKRD13B http://www.ncbi.nlm.nih.gov/gene/124930 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000043 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA ANKRD13C http://www.ncbi.nlm.nih.gov/gene/81573 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000044 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA ASAP2 http://www.ncbi.nlm.nih.gov/gene/8853 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000045 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA BACH2 http://www.ncbi.nlm.nih.gov/gene/60468 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000046 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA BMF http://www.ncbi.nlm.nih.gov/gene/90427 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000047 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA BRD4 http://www.ncbi.nlm.nih.gov/gene/23476 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000048 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA C11orf54 http://www.ncbi.nlm.nih.gov/gene/28970 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000049 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA C1orf96 http://www.ncbi.nlm.nih.gov/gene/126731 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000050 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA C2orf63 http://www.ncbi.nlm.nih.gov/gene/130162 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000051 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA C2orf72 http://www.ncbi.nlm.nih.gov/gene/257407 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000052 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA C4orf32 http://www.ncbi.nlm.nih.gov/gene/132720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000053 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA C7orf60 http://www.ncbi.nlm.nih.gov/gene/154743 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000054 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA CALM3 http://www.ncbi.nlm.nih.gov/gene/808 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000055 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA CAV2 http://www.ncbi.nlm.nih.gov/gene/858 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000056 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA CBX6 http://www.ncbi.nlm.nih.gov/gene/23466 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000057 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000058 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA CLEC2D http://www.ncbi.nlm.nih.gov/gene/29121 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000059 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA COL4A5 http://www.ncbi.nlm.nih.gov/gene/1287 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000060 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA COMMD2 http://www.ncbi.nlm.nih.gov/gene/51122 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000061 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA CSRNP2 http://www.ncbi.nlm.nih.gov/gene/81566 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000062 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA DCP2 http://www.ncbi.nlm.nih.gov/gene/167227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000063 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA DDI2 http://www.ncbi.nlm.nih.gov/gene/84301 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000064 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA DGKD http://www.ncbi.nlm.nih.gov/gene/8527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000065 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA DLD http://www.ncbi.nlm.nih.gov/gene/1738 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000066 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA DVL3 http://www.ncbi.nlm.nih.gov/gene/1857 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000067 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA ERCC6 http://www.ncbi.nlm.nih.gov/gene/2074 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000068 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA FAM105B http://www.ncbi.nlm.nih.gov/gene/90268 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000069 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA FAM136A http://www.ncbi.nlm.nih.gov/gene/84908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000070 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA FAM76B http://www.ncbi.nlm.nih.gov/gene/143684 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000071 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA FEM1B http://www.ncbi.nlm.nih.gov/gene/10116 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000072 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA FER http://www.ncbi.nlm.nih.gov/gene/2241 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000073 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA FOXJ2 http://www.ncbi.nlm.nih.gov/gene/55810 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000074 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA FRAT2 http://www.ncbi.nlm.nih.gov/gene/23401 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000075 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA GAPVD1 http://www.ncbi.nlm.nih.gov/gene/26130 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000076 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA GPATCH2 http://www.ncbi.nlm.nih.gov/gene/55105 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000077 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA HBP1 http://www.ncbi.nlm.nih.gov/gene/26959 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000078 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA HINT3 http://www.ncbi.nlm.nih.gov/gene/135114 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000079 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA HSPG2 http://www.ncbi.nlm.nih.gov/gene/3339 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000080 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA ING3 http://www.ncbi.nlm.nih.gov/gene/54556 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000081 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA IREB2 http://www.ncbi.nlm.nih.gov/gene/3658 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000082 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA ISG20L2 http://www.ncbi.nlm.nih.gov/gene/81875 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000083 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA KCTD5 http://www.ncbi.nlm.nih.gov/gene/54442 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000084 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA KIAA0895 http://www.ncbi.nlm.nih.gov/gene/23366 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000085 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA KIAA1432 http://www.ncbi.nlm.nih.gov/gene/57589 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000086 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA KIAA1549 http://www.ncbi.nlm.nih.gov/gene/57670 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000087 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA LIMA1 http://www.ncbi.nlm.nih.gov/gene/51474 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000088 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA LMNB1 http://www.ncbi.nlm.nih.gov/gene/4001 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000089 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA LYSMD1 http://www.ncbi.nlm.nih.gov/gene/388695 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000090 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA MARK3 http://www.ncbi.nlm.nih.gov/gene/4140 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000091 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA MCL1 http://www.ncbi.nlm.nih.gov/gene/4170 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000092 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA MDM2 http://www.ncbi.nlm.nih.gov/gene/4193 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000093 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA MMADHC http://www.ncbi.nlm.nih.gov/gene/27249 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000094 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA NSD1 http://www.ncbi.nlm.nih.gov/gene/64324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000095 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA OAS2 http://www.ncbi.nlm.nih.gov/gene/4939 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000096 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA PAPOLG http://www.ncbi.nlm.nih.gov/gene/64895 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000097 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA PDIK1L http://www.ncbi.nlm.nih.gov/gene/149420 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000098 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA PI15 http://www.ncbi.nlm.nih.gov/gene/51050 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000099 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA PLAG1 http://www.ncbi.nlm.nih.gov/gene/5324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000100 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA RAB11A http://www.ncbi.nlm.nih.gov/gene/8766 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000101 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA RAB30 http://www.ncbi.nlm.nih.gov/gene/27314 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000102 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA RGS1 http://www.ncbi.nlm.nih.gov/gene/5996 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000103 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA RNASEL http://www.ncbi.nlm.nih.gov/gene/6041 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000104 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA RNF19A http://www.ncbi.nlm.nih.gov/gene/25897 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000105 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA ROBO1 http://www.ncbi.nlm.nih.gov/gene/6091 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000106 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA SETDB1 http://www.ncbi.nlm.nih.gov/gene/9869 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000107 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA SIKE1 http://www.ncbi.nlm.nih.gov/gene/80143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000108 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA SIRT1 http://www.ncbi.nlm.nih.gov/gene/23411 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000109 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA SLC16A14 http://www.ncbi.nlm.nih.gov/gene/151473 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000110 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA SLC4A7 http://www.ncbi.nlm.nih.gov/gene/9497 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000111 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA SOX12 http://www.ncbi.nlm.nih.gov/gene/6666 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000112 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA SUV420H2 http://www.ncbi.nlm.nih.gov/gene/84787 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000113 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA TET2 http://www.ncbi.nlm.nih.gov/gene/54790 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000114 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA TET3 http://www.ncbi.nlm.nih.gov/gene/200424 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000115 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA TMEM111 http://www.ncbi.nlm.nih.gov/gene/55831 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000116 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA TMEM25 http://www.ncbi.nlm.nih.gov/gene/84866 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000117 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA TNFAIP3 http://www.ncbi.nlm.nih.gov/gene/7128 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000118 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA TP53INP1 http://www.ncbi.nlm.nih.gov/gene/94241 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000119 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA UBXN7 http://www.ncbi.nlm.nih.gov/gene/26043 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000120 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA VEGFA http://www.ncbi.nlm.nih.gov/gene/7422 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000121 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA WDR41 http://www.ncbi.nlm.nih.gov/gene/55255 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000122 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA WDR75 http://www.ncbi.nlm.nih.gov/gene/84128 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000123 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA WSB2 http://www.ncbi.nlm.nih.gov/gene/55884 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000124 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA ZMYM2 http://www.ncbi.nlm.nih.gov/gene/7750 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000125 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA ZNF28 http://www.ncbi.nlm.nih.gov/gene/7576 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000126 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA ZNF282 http://www.ncbi.nlm.nih.gov/gene/8427 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000127 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA ZNF445 http://www.ncbi.nlm.nih.gov/gene/353274 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000128 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA ZNF498 http://www.ncbi.nlm.nih.gov/gene/221785 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000129 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 BC-1 - Host mRNA ZNF512B http://www.ncbi.nlm.nih.gov/gene/57473 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000130 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA ABCB6 http://www.ncbi.nlm.nih.gov/gene/10058 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000131 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA ABHD13 http://www.ncbi.nlm.nih.gov/gene/84945 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000132 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA ADIPOR2 http://www.ncbi.nlm.nih.gov/gene/79602 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000133 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA AGPAT5 http://www.ncbi.nlm.nih.gov/gene/55326 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000134 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA AKT3 http://www.ncbi.nlm.nih.gov/gene/10000 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000135 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA ALG13 http://www.ncbi.nlm.nih.gov/gene/79868 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000136 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA AMMECR1 http://www.ncbi.nlm.nih.gov/gene/9949 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000137 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA AMMECR1L http://www.ncbi.nlm.nih.gov/gene/83607 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000138 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA ANKRD28 http://www.ncbi.nlm.nih.gov/gene/23243 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000139 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA ATXN7L3 http://www.ncbi.nlm.nih.gov/gene/56970 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000140 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA BMF http://www.ncbi.nlm.nih.gov/gene/90427 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000141 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA BRD4 http://www.ncbi.nlm.nih.gov/gene/23476 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000142 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA BRWD3 http://www.ncbi.nlm.nih.gov/gene/254065 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000143 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA BTG2 http://www.ncbi.nlm.nih.gov/gene/7832 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000144 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA C11orf54 http://www.ncbi.nlm.nih.gov/gene/28970 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000145 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA C12orf70 http://www.ncbi.nlm.nih.gov/gene/341346 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000146 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA C12orf76 http://www.ncbi.nlm.nih.gov/gene/400073 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000147 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA C2orf72 http://www.ncbi.nlm.nih.gov/gene/257407 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000148 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA C7orf60 http://www.ncbi.nlm.nih.gov/gene/154743 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000149 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA CALM3 http://www.ncbi.nlm.nih.gov/gene/808 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000150 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA CBX6 http://www.ncbi.nlm.nih.gov/gene/23466 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000151 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000152 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA CCSAP(C1orf96) - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000153 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA CCT4 http://www.ncbi.nlm.nih.gov/gene/10575 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000154 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA CCT8 http://www.ncbi.nlm.nih.gov/gene/644131 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000155 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA CLEC2D http://www.ncbi.nlm.nih.gov/gene/29121 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000156 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA COL19A1 http://www.ncbi.nlm.nih.gov/gene/1310 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000157 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA COL1A1 http://www.ncbi.nlm.nih.gov/gene/1277 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000158 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA CXCL10 http://www.ncbi.nlm.nih.gov/gene/3627 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000159 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA DCP2 http://www.ncbi.nlm.nih.gov/gene/167227 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000160 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA DDI2 http://www.ncbi.nlm.nih.gov/gene/84301 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000161 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA DGKD http://www.ncbi.nlm.nih.gov/gene/8527 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000162 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA DGKH http://www.ncbi.nlm.nih.gov/gene/160851 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000163 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA DHX36 http://www.ncbi.nlm.nih.gov/gene/170506 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000164 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA DHX8 http://www.ncbi.nlm.nih.gov/gene/1659 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000165 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA DPM1 http://www.ncbi.nlm.nih.gov/gene/8813 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000166 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA DTL http://www.ncbi.nlm.nih.gov/gene/51514 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000167 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA DVL3 http://www.ncbi.nlm.nih.gov/gene/1857 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000168 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA DYNLT1 http://www.ncbi.nlm.nih.gov/gene/6993 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000169 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA E2F7 http://www.ncbi.nlm.nih.gov/gene/144455 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000170 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA EPC1 http://www.ncbi.nlm.nih.gov/gene/80314 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000171 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA ERCC6 http://www.ncbi.nlm.nih.gov/gene/2074 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000172 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA FAM105B http://www.ncbi.nlm.nih.gov/gene/90268 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000173 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA FAM76B http://www.ncbi.nlm.nih.gov/gene/143684 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000174 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA FEM1B http://www.ncbi.nlm.nih.gov/gene/10116 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000175 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA GAPVD1 http://www.ncbi.nlm.nih.gov/gene/26130 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000176 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA HECTD1 http://www.ncbi.nlm.nih.gov/gene/25831 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000177 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA HIST1H2BG http://www.ncbi.nlm.nih.gov/gene/8343 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000178 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA IFNAR1 http://www.ncbi.nlm.nih.gov/gene/3454 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000179 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA ISG20L2 http://www.ncbi.nlm.nih.gov/gene/81875 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000180 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA KIAA1432 http://www.ncbi.nlm.nih.gov/gene/57589 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000181 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA LY75 http://www.ncbi.nlm.nih.gov/gene/4065 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000182 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA LYSMD1 http://www.ncbi.nlm.nih.gov/gene/388695 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000183 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA MARK3 http://www.ncbi.nlm.nih.gov/gene/4140 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000184 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA MCL1 http://www.ncbi.nlm.nih.gov/gene/4170 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000185 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA MDM2 http://www.ncbi.nlm.nih.gov/gene/4193 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000186 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA MPZL3 http://www.ncbi.nlm.nih.gov/gene/196264 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000187 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA MSL3 http://www.ncbi.nlm.nih.gov/gene/10943 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000188 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA NCUBE1 http://www.ncbi.nlm.nih.gov/gene/51465 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000189 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA NEDD9 http://www.ncbi.nlm.nih.gov/gene/4739 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000190 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA NKIRAS2 http://www.ncbi.nlm.nih.gov/gene/28511 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000191 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA NSD1 http://www.ncbi.nlm.nih.gov/gene/64324 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000192 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA PGAP2 http://www.ncbi.nlm.nih.gov/gene/27315 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000193 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA PLAG1 http://www.ncbi.nlm.nih.gov/gene/5324 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000194 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA PPAPR3 # - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000195 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA PTP4A1 http://www.ncbi.nlm.nih.gov/gene/7803 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000196 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA RAB30 http://www.ncbi.nlm.nih.gov/gene/27314 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000197 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA RCBTB2 http://www.ncbi.nlm.nih.gov/gene/1102 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000198 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA REV3L http://www.ncbi.nlm.nih.gov/gene/5980 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000199 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA RGS1 http://www.ncbi.nlm.nih.gov/gene/5996 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000200 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA RLF http://www.ncbi.nlm.nih.gov/gene/6018 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000201 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA RNF19A http://www.ncbi.nlm.nih.gov/gene/25897 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000202 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA ROBO1 http://www.ncbi.nlm.nih.gov/gene/6091 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000203 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA SEC24A http://www.ncbi.nlm.nih.gov/gene/10802 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000204 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA SH3PXD2A http://www.ncbi.nlm.nih.gov/gene/9644 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000205 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA SLC19A2 http://www.ncbi.nlm.nih.gov/gene/10560 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000206 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA SPARC http://www.ncbi.nlm.nih.gov/gene/6678 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000207 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA TET3 http://www.ncbi.nlm.nih.gov/gene/200424 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000208 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA TFRC http://www.ncbi.nlm.nih.gov/gene/7037 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000209 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA TMEM48 http://www.ncbi.nlm.nih.gov/gene/55706 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000210 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA TNFAIP3 http://www.ncbi.nlm.nih.gov/gene/7128 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000211 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA TNRC6B http://www.ncbi.nlm.nih.gov/gene/23112 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000212 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA TRAM1 http://www.ncbi.nlm.nih.gov/gene/23471 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000213 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA USP10 http://www.ncbi.nlm.nih.gov/gene/9100 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000214 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA WBP1L(C10orf26) - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000215 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA WDFY1 http://www.ncbi.nlm.nih.gov/gene/57590 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000216 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA WDR41 http://www.ncbi.nlm.nih.gov/gene/55255 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000217 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA ZFP91 http://www.ncbi.nlm.nih.gov/gene/386607 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000218 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA ZMYM2 http://www.ncbi.nlm.nih.gov/gene/7750 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000219 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA ZNF28 http://www.ncbi.nlm.nih.gov/gene/7576 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000220 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA ZNF282 http://www.ncbi.nlm.nih.gov/gene/8427 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000221 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA ZNF292 http://www.ncbi.nlm.nih.gov/gene/23036 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000222 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA ZNF608 http://www.ncbi.nlm.nih.gov/gene/57507 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000223 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(ebv-mir-bart1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 Lymphoblastoid cell lines - Host mRNA ZSCAN25(ZNF498) - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000224 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA ACSL3 http://www.ncbi.nlm.nih.gov/gene/2181 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000225 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA AK3 http://www.ncbi.nlm.nih.gov/gene/50808 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000226 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA AKAP13 http://www.ncbi.nlm.nih.gov/gene/11214 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000227 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA ALS2CR8 http://www.ncbi.nlm.nih.gov/gene/79800 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000228 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA ATF7 http://www.ncbi.nlm.nih.gov/gene/11016 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000229 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA C9orf156 http://www.ncbi.nlm.nih.gov/gene/51531 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000230 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA CCDC117 http://www.ncbi.nlm.nih.gov/gene/150275 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000231 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000232 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA CD2BP2 http://www.ncbi.nlm.nih.gov/gene/10421 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000233 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA CDK4 http://www.ncbi.nlm.nih.gov/gene/1019 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000234 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA CETN3 http://www.ncbi.nlm.nih.gov/gene/1070 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000235 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA CLEC16A http://www.ncbi.nlm.nih.gov/gene/23274 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000236 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA CLIP1 http://www.ncbi.nlm.nih.gov/gene/6249 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000237 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA COX16 http://www.ncbi.nlm.nih.gov/gene/51241 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000238 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA CPNE3 http://www.ncbi.nlm.nih.gov/gene/8895 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000239 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA CREB1 http://www.ncbi.nlm.nih.gov/gene/1385 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000240 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA CRK http://www.ncbi.nlm.nih.gov/gene/1398 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000241 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA DICER1 http://www.ncbi.nlm.nih.gov/gene/23405 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000242 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA DNAL1 http://www.ncbi.nlm.nih.gov/gene/83544 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000243 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA DYNC1LI2 http://www.ncbi.nlm.nih.gov/gene/1783 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000244 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA ELF2 http://www.ncbi.nlm.nih.gov/gene/1998 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000245 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA FAM135A http://www.ncbi.nlm.nih.gov/gene/57579 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000246 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA FMR1 http://www.ncbi.nlm.nih.gov/gene/2332 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000247 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA FNIP2 http://www.ncbi.nlm.nih.gov/gene/57600 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000248 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA GUF1 http://www.ncbi.nlm.nih.gov/gene/60558 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000249 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA HERPUD1 http://www.ncbi.nlm.nih.gov/gene/9709 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000250 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA HIBCH http://www.ncbi.nlm.nih.gov/gene/26275 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000251 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA HNRNPK http://www.ncbi.nlm.nih.gov/gene/3190 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000252 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA HS3ST3B1 http://www.ncbi.nlm.nih.gov/gene/9953 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000253 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA INO80D http://www.ncbi.nlm.nih.gov/gene/54891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000254 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA IPO9 http://www.ncbi.nlm.nih.gov/gene/55705 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000255 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA IRF1 http://www.ncbi.nlm.nih.gov/gene/3659 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000256 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA IRF9 http://www.ncbi.nlm.nih.gov/gene/10379 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000257 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA KBTBD6 http://www.ncbi.nlm.nih.gov/gene/89890 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000258 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA KIAA1468 http://www.ncbi.nlm.nih.gov/gene/57614 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000259 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA KIF23 http://www.ncbi.nlm.nih.gov/gene/9493 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000260 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA KIF3B http://www.ncbi.nlm.nih.gov/gene/9371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000261 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA KPNA1 http://www.ncbi.nlm.nih.gov/gene/3836 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000262 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA LAPTM4A http://www.ncbi.nlm.nih.gov/gene/9741 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000263 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA LCP1 http://www.ncbi.nlm.nih.gov/gene/3936 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000264 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA LIMS1 http://www.ncbi.nlm.nih.gov/gene/3987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000265 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA LIN28B http://www.ncbi.nlm.nih.gov/gene/389421 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000266 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA LNPEP http://www.ncbi.nlm.nih.gov/gene/4012 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000267 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA MAML1 http://www.ncbi.nlm.nih.gov/gene/9794 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000268 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA MCL1 http://www.ncbi.nlm.nih.gov/gene/4170 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000269 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA MIER1 http://www.ncbi.nlm.nih.gov/gene/57708 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000270 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA MKL2 http://www.ncbi.nlm.nih.gov/gene/57496 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000271 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA NFAT5 http://www.ncbi.nlm.nih.gov/gene/10725 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000272 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA NIN http://www.ncbi.nlm.nih.gov/gene/51199 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000273 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA NR1D2 http://www.ncbi.nlm.nih.gov/gene/9975 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000274 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA OCRL http://www.ncbi.nlm.nih.gov/gene/4952 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000275 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA OPA1 http://www.ncbi.nlm.nih.gov/gene/4976 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000276 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA PGRMC1 http://www.ncbi.nlm.nih.gov/gene/10857 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000277 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA PLCXD2 http://www.ncbi.nlm.nih.gov/gene/90102 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000278 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA PRDM1 http://www.ncbi.nlm.nih.gov/gene/639 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000279 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA PTPN9 http://www.ncbi.nlm.nih.gov/gene/5780 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000280 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA PXMP4 http://www.ncbi.nlm.nih.gov/gene/11264 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000281 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA RBM27 http://www.ncbi.nlm.nih.gov/gene/54439 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000282 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA RC3H1 http://www.ncbi.nlm.nih.gov/gene/149041 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000283 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA RGL2 http://www.ncbi.nlm.nih.gov/gene/5863 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000284 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA RNF125 http://www.ncbi.nlm.nih.gov/gene/54941 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000285 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA SACS http://www.ncbi.nlm.nih.gov/gene/26278 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000286 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA SH3GL1 http://www.ncbi.nlm.nih.gov/gene/6455 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000287 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA SLC39A6 http://www.ncbi.nlm.nih.gov/gene/25800 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000288 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA SLC39A9 http://www.ncbi.nlm.nih.gov/gene/55334 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000289 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA SNX10 http://www.ncbi.nlm.nih.gov/gene/29887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000290 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA SP100 http://www.ncbi.nlm.nih.gov/gene/6672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000291 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA STX12 http://www.ncbi.nlm.nih.gov/gene/23673 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000292 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA SYPL1 http://www.ncbi.nlm.nih.gov/gene/6856 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000293 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA TBC1D20 http://www.ncbi.nlm.nih.gov/gene/128637 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000294 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA TFRC http://www.ncbi.nlm.nih.gov/gene/7037 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000295 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA TRIM24 http://www.ncbi.nlm.nih.gov/gene/8805 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000296 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA UBE2CBP http://www.ncbi.nlm.nih.gov/gene/90025 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000297 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA UBN2 http://www.ncbi.nlm.nih.gov/gene/254048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000298 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA UHRF1BP1 http://www.ncbi.nlm.nih.gov/gene/54887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000299 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA XPO4 http://www.ncbi.nlm.nih.gov/gene/64328 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000300 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA YOD1 http://www.ncbi.nlm.nih.gov/gene/55432 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000301 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA ZBTB24 http://www.ncbi.nlm.nih.gov/gene/9841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000302 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA ZFP91 http://www.ncbi.nlm.nih.gov/gene/386607 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000303 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 BC-1 - Host mRNA ZNF133 http://www.ncbi.nlm.nih.gov/gene/7692 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000304 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA AK3 http://www.ncbi.nlm.nih.gov/gene/50808 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000305 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA AKAP13 http://www.ncbi.nlm.nih.gov/gene/11214 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000306 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA C17orf48 http://www.ncbi.nlm.nih.gov/gene/56985 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000307 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA C2CD2 http://www.ncbi.nlm.nih.gov/gene/25966 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000308 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA C9orf156 http://www.ncbi.nlm.nih.gov/gene/51531 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000309 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA CARF(ALS2CR8) - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000310 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA CLIP1 http://www.ncbi.nlm.nih.gov/gene/6249 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000311 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA CLUAP1 http://www.ncbi.nlm.nih.gov/gene/23059 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000312 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA CRK http://www.ncbi.nlm.nih.gov/gene/1398 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000313 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA CSNK1G3 http://www.ncbi.nlm.nih.gov/gene/1456 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000314 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA DRAM1 http://www.ncbi.nlm.nih.gov/gene/55332 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000315 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA DYNC1LI2 http://www.ncbi.nlm.nih.gov/gene/1783 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000316 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA FAM120A http://www.ncbi.nlm.nih.gov/gene/23196 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000317 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA FMR1 http://www.ncbi.nlm.nih.gov/gene/2332 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000318 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA GRN http://www.ncbi.nlm.nih.gov/gene/2896 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000319 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA HERPUD1 http://www.ncbi.nlm.nih.gov/gene/9709 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000320 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA HIBCH http://www.ncbi.nlm.nih.gov/gene/26275 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000321 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA IPO9 http://www.ncbi.nlm.nih.gov/gene/55705 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000322 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA IRF1 http://www.ncbi.nlm.nih.gov/gene/3659 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000323 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA LNPEP http://www.ncbi.nlm.nih.gov/gene/4012 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000324 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA LY75 http://www.ncbi.nlm.nih.gov/gene/4065 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000325 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA MIER1 http://www.ncbi.nlm.nih.gov/gene/57708 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000326 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA MKL2 http://www.ncbi.nlm.nih.gov/gene/57496 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000327 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA NFAT5 http://www.ncbi.nlm.nih.gov/gene/10725 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000328 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA OPA1 http://www.ncbi.nlm.nih.gov/gene/4976 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000329 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA PCNA http://www.ncbi.nlm.nih.gov/gene/5111 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000330 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA PDCD1LG2 http://www.ncbi.nlm.nih.gov/gene/80380 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000331 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA PHF17 http://www.ncbi.nlm.nih.gov/gene/79960 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000332 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA PIK3R1 http://www.ncbi.nlm.nih.gov/gene/5295 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000333 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA PRDM1 http://www.ncbi.nlm.nih.gov/gene/639 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000334 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA RBM27 http://www.ncbi.nlm.nih.gov/gene/54439 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000335 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA SARM1 http://www.ncbi.nlm.nih.gov/gene/23098 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000336 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA SH3GL1 http://www.ncbi.nlm.nih.gov/gene/6455 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000337 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA SIK2 http://www.ncbi.nlm.nih.gov/gene/23235 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000338 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA SLK http://www.ncbi.nlm.nih.gov/gene/9748 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000339 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA SMARCB1 http://www.ncbi.nlm.nih.gov/gene/6598 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000340 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA SNX10 http://www.ncbi.nlm.nih.gov/gene/29887 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000341 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA SP100 http://www.ncbi.nlm.nih.gov/gene/6672 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000342 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA SRRM2 http://www.ncbi.nlm.nih.gov/gene/100132779 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000343 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA STX12 http://www.ncbi.nlm.nih.gov/gene/23673 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000344 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA SUOX http://www.ncbi.nlm.nih.gov/gene/6821 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000345 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA TRAF4 http://www.ncbi.nlm.nih.gov/gene/9618 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00000346 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA UBN2 http://www.ncbi.nlm.nih.gov/gene/254048 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000347 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA WARS http://www.ncbi.nlm.nih.gov/gene/7453 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000348 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA XPO6 http://www.ncbi.nlm.nih.gov/gene/23214 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000349 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA YOD1 http://www.ncbi.nlm.nih.gov/gene/55432 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000350 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA ZNF148 http://www.ncbi.nlm.nih.gov/gene/7707 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000351 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(ebv-mir-bart1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 Lymphoblastoid cell lines - Host mRNA ZNF555 http://www.ncbi.nlm.nih.gov/gene/148254 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00000352 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA ACSL4 http://www.ncbi.nlm.nih.gov/gene/2182 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000353 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA ADSS http://www.ncbi.nlm.nih.gov/gene/159 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000354 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA ANKRD11 http://www.ncbi.nlm.nih.gov/gene/100128265 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000355 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA AP1S3 http://www.ncbi.nlm.nih.gov/gene/130340 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000356 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA ARL2BP http://www.ncbi.nlm.nih.gov/gene/23568 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000357 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA ARMC8 http://www.ncbi.nlm.nih.gov/gene/25852 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000358 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA ATG5 http://www.ncbi.nlm.nih.gov/gene/9474 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000359 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA BTBD1 http://www.ncbi.nlm.nih.gov/gene/53339 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000360 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA C17orf63 http://www.ncbi.nlm.nih.gov/gene/55731 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000361 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA CBX5 http://www.ncbi.nlm.nih.gov/gene/23468 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000362 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA CCDC21 http://www.ncbi.nlm.nih.gov/gene/64793 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000363 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000364 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA CDC42 http://www.ncbi.nlm.nih.gov/gene/998 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000365 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA CLCC1 http://www.ncbi.nlm.nih.gov/gene/23155 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000366 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA CLINT1 http://www.ncbi.nlm.nih.gov/gene/9685 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000367 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA CMTM6 http://www.ncbi.nlm.nih.gov/gene/54918 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000368 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA CPEB2 http://www.ncbi.nlm.nih.gov/gene/132864 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000369 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA CPEB3 http://www.ncbi.nlm.nih.gov/gene/22849 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000370 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA CPEB4 http://www.ncbi.nlm.nih.gov/gene/80315 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000371 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA CROT http://www.ncbi.nlm.nih.gov/gene/54677 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000372 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA CUGBP2 http://www.ncbi.nlm.nih.gov/gene/10659 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000373 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA DDX3Y http://www.ncbi.nlm.nih.gov/gene/8653 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000374 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA FAM120A http://www.ncbi.nlm.nih.gov/gene/23196 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000375 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA FBXW7 http://www.ncbi.nlm.nih.gov/gene/55294 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000376 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA GEMIN4 http://www.ncbi.nlm.nih.gov/gene/50628 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000377 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA HECW2 http://www.ncbi.nlm.nih.gov/gene/57520 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000378 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA IDS http://www.ncbi.nlm.nih.gov/gene/3423 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000379 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA IREB2 http://www.ncbi.nlm.nih.gov/gene/3658 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000380 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA MEX3C http://www.ncbi.nlm.nih.gov/gene/51320 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000381 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA MLL http://www.ncbi.nlm.nih.gov/gene/4297 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000382 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA MORC3 http://www.ncbi.nlm.nih.gov/gene/23515 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000383 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA MREG http://www.ncbi.nlm.nih.gov/gene/55686 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000384 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA NCOA3 http://www.ncbi.nlm.nih.gov/gene/8202 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000385 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA NOM1 http://www.ncbi.nlm.nih.gov/gene/64434 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000386 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA NUP133 http://www.ncbi.nlm.nih.gov/gene/55746 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000387 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA NUP43 http://www.ncbi.nlm.nih.gov/gene/348995 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000388 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA PAFAH1B1 http://www.ncbi.nlm.nih.gov/gene/5048 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000389 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA PER2 http://www.ncbi.nlm.nih.gov/gene/8864 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000390 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA PPP6C http://www.ncbi.nlm.nih.gov/gene/5537 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000391 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA RASGRP3 http://www.ncbi.nlm.nih.gov/gene/25780 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000392 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA RBBP6 http://www.ncbi.nlm.nih.gov/gene/5930 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000393 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA RBM26 http://www.ncbi.nlm.nih.gov/gene/64062 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000394 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA RNF213 http://www.ncbi.nlm.nih.gov/gene/57674 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000395 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA SAP18 http://www.ncbi.nlm.nih.gov/gene/10284 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000396 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA SEL1L http://www.ncbi.nlm.nih.gov/gene/6400 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000397 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA SMCHD1 http://www.ncbi.nlm.nih.gov/gene/23347 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000398 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA SPTLC2 http://www.ncbi.nlm.nih.gov/gene/9517 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000399 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA STARD7 http://www.ncbi.nlm.nih.gov/gene/56910 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000400 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA SUMO3 http://www.ncbi.nlm.nih.gov/gene/285829 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000401 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA TFRC http://www.ncbi.nlm.nih.gov/gene/7037 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000402 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA TNFRSF10B http://www.ncbi.nlm.nih.gov/gene/8795 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000403 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA TOP2A http://www.ncbi.nlm.nih.gov/gene/7153 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000404 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA UBR5 http://www.ncbi.nlm.nih.gov/gene/730429 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000405 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA VPS36 http://www.ncbi.nlm.nih.gov/gene/51028 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000406 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA XIAP http://www.ncbi.nlm.nih.gov/gene/331 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000407 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA ZNF180 http://www.ncbi.nlm.nih.gov/gene/7733 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000408 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA ZNF217 http://www.ncbi.nlm.nih.gov/gene/7764 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000409 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 Jijoye cells - Host mRNA ZNF770 http://www.ncbi.nlm.nih.gov/gene/54989 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000410 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10-5p(ebv-mir-bart10*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004817 BC-1 - Host mRNA BRPF3 http://www.ncbi.nlm.nih.gov/gene/27154 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000411 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10-5p(ebv-mir-bart10*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004817 BC-1 - Host mRNA C6orf106 http://www.ncbi.nlm.nih.gov/gene/64771 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000412 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10-5p(ebv-mir-bart10*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004817 BC-1 - Host mRNA FAM126A http://www.ncbi.nlm.nih.gov/gene/84668 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000413 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10-5p(ebv-mir-bart10*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004817 BC-1 - Host mRNA KLHDC5 http://www.ncbi.nlm.nih.gov/gene/57542 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000414 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10-5p(ebv-mir-bart10*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004817 BC-1 - Host mRNA MDM2 http://www.ncbi.nlm.nih.gov/gene/4193 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000415 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10-5p(ebv-mir-bart10*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004817 BC-1 - Host mRNA SIRT3 http://www.ncbi.nlm.nih.gov/gene/23410 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000416 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART10-5p(ebv-mir-bart10*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004817 BC-1 - Host mRNA SR140 http://www.ncbi.nlm.nih.gov/gene/23350 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000417 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-3p(ebv-mir-bart11-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003422 BC-1 - Host mRNA PPP1R8 http://www.ncbi.nlm.nih.gov/gene/5511 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000418 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-3p(ebv-mir-bart11-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003422 BC-1 - Host mRNA SETD7 http://www.ncbi.nlm.nih.gov/gene/80854 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000419 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA ATG4A http://www.ncbi.nlm.nih.gov/gene/115201 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000420 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA BTG2 http://www.ncbi.nlm.nih.gov/gene/7832 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000421 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA CD200R1 http://www.ncbi.nlm.nih.gov/gene/131450 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000422 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA EPDR1 http://www.ncbi.nlm.nih.gov/gene/54749 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000423 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA FAM82A2 http://www.ncbi.nlm.nih.gov/gene/55177 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000424 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA FBXL20 http://www.ncbi.nlm.nih.gov/gene/84961 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000425 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA FOXP2 http://www.ncbi.nlm.nih.gov/gene/93986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000426 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA GNB1 http://www.ncbi.nlm.nih.gov/gene/2782 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000427 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA HN1 http://www.ncbi.nlm.nih.gov/gene/51155 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000428 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA KHDRBS3 http://www.ncbi.nlm.nih.gov/gene/10656 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000429 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA KIAA0317 http://www.ncbi.nlm.nih.gov/gene/9870 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000430 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA KIAA1219 http://www.ncbi.nlm.nih.gov/gene/57148 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000431 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA KLF13 http://www.ncbi.nlm.nih.gov/gene/51621 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000432 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA MCL1 http://www.ncbi.nlm.nih.gov/gene/4170 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000433 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA MDM2 http://www.ncbi.nlm.nih.gov/gene/4193 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000434 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA MID1IP1 http://www.ncbi.nlm.nih.gov/gene/58526 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000435 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA NPC1 http://www.ncbi.nlm.nih.gov/gene/4864 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000436 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA NRAS http://www.ncbi.nlm.nih.gov/gene/4893 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000437 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA NSUN6 http://www.ncbi.nlm.nih.gov/gene/221078 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000438 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA OAS2 http://www.ncbi.nlm.nih.gov/gene/4939 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000439 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA PAFAH1B1 http://www.ncbi.nlm.nih.gov/gene/5048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000440 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA PHF23 http://www.ncbi.nlm.nih.gov/gene/79142 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000441 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA PHKB http://www.ncbi.nlm.nih.gov/gene/5257 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000442 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA PTPLAD1 http://www.ncbi.nlm.nih.gov/gene/51495 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000443 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA RC3H2 http://www.ncbi.nlm.nih.gov/gene/54542 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000444 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA RNMT http://www.ncbi.nlm.nih.gov/gene/8731 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000445 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA SESN2 http://www.ncbi.nlm.nih.gov/gene/83667 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000446 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA TRAM2 http://www.ncbi.nlm.nih.gov/gene/9697 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000447 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA TRIB1 http://www.ncbi.nlm.nih.gov/gene/10221 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000448 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA WASL http://www.ncbi.nlm.nih.gov/gene/8976 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000449 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART11-5p(ebv-mir-bart11-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003421 BC-1 - Host mRNA XIAP http://www.ncbi.nlm.nih.gov/gene/331 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000450 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART12(miR-BART12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 epithelial cell lines - Host Protein BCL2L11(BimEL) http://www.ncbi.nlm.nih.gov/gene/396632 Downregulation Northern Blot analysis and quantitative RT-PCR, Western Blot analysis, Microarray analysis, ciferase Assays. 21333317 Analysis of the BimEL protein levels in cells expressing the miRNAs revealed that its expression was affected by several of the individual miRNAs with cell lines expressing miR-BART1, 3, 9, 11 and 12 all having decreased BimEL levels (Figure 6B and C). VHID00000451 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART12(miR-BART12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 epithelial cell lines - Host mRNA BCL2L11(BIM) http://www.ncbi.nlm.nih.gov/gene/396632 Downregulation Northern Blot analysis and quantitative RT-PCR, Western Blot analysis, Microarray analysis, ciferase Assays. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VHID00000452 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA ABI2 http://www.ncbi.nlm.nih.gov/gene/10152 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000453 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA ARFGEF2 http://www.ncbi.nlm.nih.gov/gene/10564 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000454 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA ATP13A3 http://www.ncbi.nlm.nih.gov/gene/79572 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000455 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA C1orf55 http://www.ncbi.nlm.nih.gov/gene/163859 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000456 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA C6orf120 http://www.ncbi.nlm.nih.gov/gene/387263 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000457 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA C9orf72 http://www.ncbi.nlm.nih.gov/gene/203228 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000458 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA CBL http://www.ncbi.nlm.nih.gov/gene/867 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000459 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA CCDC99 http://www.ncbi.nlm.nih.gov/gene/54908 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000460 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA CSNK1G1 http://www.ncbi.nlm.nih.gov/gene/53944 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000461 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA CTPS http://www.ncbi.nlm.nih.gov/gene/1503 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000462 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA EIF5 http://www.ncbi.nlm.nih.gov/gene/1983 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000463 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA FAM174A http://www.ncbi.nlm.nih.gov/gene/345757 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000464 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA HK2 http://www.ncbi.nlm.nih.gov/gene/3099 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000465 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA INTS6 http://www.ncbi.nlm.nih.gov/gene/26512 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000466 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA LAMP2 http://www.ncbi.nlm.nih.gov/gene/3920 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000467 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA LHFPL2 http://www.ncbi.nlm.nih.gov/gene/10184 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000468 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA MAP3K1 http://www.ncbi.nlm.nih.gov/gene/4214 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000469 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA MAST3 http://www.ncbi.nlm.nih.gov/gene/23031 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000470 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA MCL1 http://www.ncbi.nlm.nih.gov/gene/4170 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000471 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA MED9 http://www.ncbi.nlm.nih.gov/gene/55090 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000472 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA MKLN1 http://www.ncbi.nlm.nih.gov/gene/4289 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000473 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA NDUFB2 http://www.ncbi.nlm.nih.gov/gene/4708 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000474 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA NKIRAS2 http://www.ncbi.nlm.nih.gov/gene/28511 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000475 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA NUCKS1 http://www.ncbi.nlm.nih.gov/gene/64710 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000476 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA NUFIP2 http://www.ncbi.nlm.nih.gov/gene/57532 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000477 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA PPM1A http://www.ncbi.nlm.nih.gov/gene/5494 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000478 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA SC5DL http://www.ncbi.nlm.nih.gov/gene/6309 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000479 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA SCOC http://www.ncbi.nlm.nih.gov/gene/60592 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000480 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA SFRS18 http://www.ncbi.nlm.nih.gov/gene/25957 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000481 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA SLC41A1 http://www.ncbi.nlm.nih.gov/gene/254428 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000482 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA TBC1D2B http://www.ncbi.nlm.nih.gov/gene/23102 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000483 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA TET3 http://www.ncbi.nlm.nih.gov/gene/200424 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000484 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA THUMPD1 http://www.ncbi.nlm.nih.gov/gene/55623 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000485 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA TIAL1 http://www.ncbi.nlm.nih.gov/gene/7073 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000486 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA TMEM60 http://www.ncbi.nlm.nih.gov/gene/85025 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000487 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA TOPBP1 http://www.ncbi.nlm.nih.gov/gene/11073 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000488 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA USP31 http://www.ncbi.nlm.nih.gov/gene/57478 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000489 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 Jijoye cells - Host mRNA ZFR http://www.ncbi.nlm.nih.gov/gene/51663 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00000490 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13-3p(BART-13-3P) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003424 - - Host Protein CAPRIN2 http://www.ncbi.nlm.nih.gov/gene/65981 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00000491 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13-5p(ebv-mir-bart13*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004818 BC-1 - Host mRNA FZD1 http://www.ncbi.nlm.nih.gov/gene/8321 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000492 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13-5p(ebv-mir-bart13*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004818 BC-1 - Host mRNA KPNA5 http://www.ncbi.nlm.nih.gov/gene/3841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000493 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13-5p(ebv-mir-bart13*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004818 BC-1 - Host mRNA RC3H2 http://www.ncbi.nlm.nih.gov/gene/54542 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000494 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13-5p(ebv-mir-bart13*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004818 BC-1 - Host mRNA TST http://www.ncbi.nlm.nih.gov/gene/7263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000495 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART13-5p(ebv-mir-bart13*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004818 BC-1 - Host mRNA VAMP4 http://www.ncbi.nlm.nih.gov/gene/8674 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000496 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART14-5p(ebv-mir-bart14*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003425 BC-1 - Host mRNA ARID3A http://www.ncbi.nlm.nih.gov/gene/1820 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000497 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART14-5p(ebv-mir-bart14*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003425 BC-1 - Host mRNA B2M http://www.ncbi.nlm.nih.gov/gene/567 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000498 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART14-5p(ebv-mir-bart14*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003425 BC-1 - Host mRNA C1orf52 http://www.ncbi.nlm.nih.gov/gene/148423 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000499 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART14-5p(ebv-mir-bart14*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003425 BC-1 - Host mRNA C7orf36 http://www.ncbi.nlm.nih.gov/gene/57002 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000500 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART14-5p(ebv-mir-bart14*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003425 BC-1 - Host mRNA CREBZF http://www.ncbi.nlm.nih.gov/gene/58487 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000501 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART14-5p(ebv-mir-bart14*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003425 BC-1 - Host mRNA CTSC http://www.ncbi.nlm.nih.gov/gene/1075 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000502 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART14-5p(ebv-mir-bart14*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003425 BC-1 - Host mRNA DCC http://www.ncbi.nlm.nih.gov/gene/1630 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000503 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART14-5p(ebv-mir-bart14*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003425 BC-1 - Host mRNA FBXO33 http://www.ncbi.nlm.nih.gov/gene/254170 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000504 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART14-5p(ebv-mir-bart14*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003425 BC-1 - Host mRNA G3BP1 http://www.ncbi.nlm.nih.gov/gene/10146 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000505 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART14-5p(ebv-mir-bart14*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003425 BC-1 - Host mRNA H2AFX http://www.ncbi.nlm.nih.gov/gene/3014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000506 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART14-5p(ebv-mir-bart14*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003425 BC-1 - Host mRNA MFSD8 http://www.ncbi.nlm.nih.gov/gene/256471 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000507 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART14-5p(ebv-mir-bart14*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003425 BC-1 - Host mRNA PRKAR1A http://www.ncbi.nlm.nih.gov/gene/5573 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000508 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART14-5p(ebv-mir-bart14*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003425 BC-1 - Host mRNA PTEN http://www.ncbi.nlm.nih.gov/gene/11191 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000509 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART14-5p(ebv-mir-bart14*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003425 BC-1 - Host mRNA SFRS6 http://www.ncbi.nlm.nih.gov/gene/644422 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000510 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART14-5p(ebv-mir-bart14*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003425 BC-1 - Host mRNA TMEM184C http://www.ncbi.nlm.nih.gov/gene/55751 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000511 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART14-5p(ebv-mir-bart14*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003425 BC-1 - Host mRNA VMA21 http://www.ncbi.nlm.nih.gov/gene/203547 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000512 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART14-5p(ebv-mir-bart14*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003425 BC-1 - Host mRNA WTAP http://www.ncbi.nlm.nih.gov/gene/9589 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000513 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART15(miR-BART15-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003713 EBV-negative cells Upregulation Host mRNA BIRC6(BRUCE) http://www.ncbi.nlm.nih.gov/gene/57448 Downregulation Luciferase assays. 23678170 miR-BART15-3p downregulated the BRUCE protein in EBV-negative cells, while the inhibitor for miR-BART15-3p upregulated the BRUCE protein in EBV-infected cells without affecting the BRUCE mRNA level. VHID00000514 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART16 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 human B cells - Host Protein TOMM22 http://www.ncbi.nlm.nih.gov/gene/56993 Downregulation Luciferase assays, RISC immunoprecipitation assay.TaqMan PCR.RIP-Chip analysis. 20413099 Luciferase assays with sensor vectors carrying the 3'UTRs of TOMM22 and IPO7 demonstrated significant repression by ebv-miR-BART16 and ebv-miR-BART3, respectively. VHID00000515 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA ACTR3 http://www.ncbi.nlm.nih.gov/gene/10096 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000516 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA ADAR http://www.ncbi.nlm.nih.gov/gene/103 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000517 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA AMMECR1 http://www.ncbi.nlm.nih.gov/gene/9949 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000518 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA APOL6 http://www.ncbi.nlm.nih.gov/gene/80830 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000519 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA ARL15 http://www.ncbi.nlm.nih.gov/gene/54622 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000520 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA ARL6IP1 http://www.ncbi.nlm.nih.gov/gene/23204 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000521 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA ASH1L http://www.ncbi.nlm.nih.gov/gene/55870 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000522 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA ATP13A3 http://www.ncbi.nlm.nih.gov/gene/79572 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000523 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA ATXN1 http://www.ncbi.nlm.nih.gov/gene/6310 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000524 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA BCL11A http://www.ncbi.nlm.nih.gov/gene/53335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000525 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA C10orf28 http://www.ncbi.nlm.nih.gov/gene/27291 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000526 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA C1orf58 http://www.ncbi.nlm.nih.gov/gene/148362 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000527 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA C1orf96 http://www.ncbi.nlm.nih.gov/gene/126731 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000528 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA C3orf1 http://www.ncbi.nlm.nih.gov/gene/51300 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000529 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA C4orf32 http://www.ncbi.nlm.nih.gov/gene/132720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000530 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA CALCOCO1 http://www.ncbi.nlm.nih.gov/gene/57658 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000531 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA CAST http://www.ncbi.nlm.nih.gov/gene/831 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000532 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA CDKN2AIP http://www.ncbi.nlm.nih.gov/gene/55602 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000533 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA CHD7 http://www.ncbi.nlm.nih.gov/gene/55636 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000534 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA CNOT6L http://www.ncbi.nlm.nih.gov/gene/246175 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000535 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA DDHD1 http://www.ncbi.nlm.nih.gov/gene/80821 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000536 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA DNAJC27 http://www.ncbi.nlm.nih.gov/gene/51277 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000537 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA EEF2K http://www.ncbi.nlm.nih.gov/gene/29904 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000538 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA EPC1 http://www.ncbi.nlm.nih.gov/gene/80314 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000539 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA FAM133A http://www.ncbi.nlm.nih.gov/gene/286499 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000540 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA FAM76A http://www.ncbi.nlm.nih.gov/gene/199870 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000541 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA FBXO28 http://www.ncbi.nlm.nih.gov/gene/23219 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000542 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA FLI1 http://www.ncbi.nlm.nih.gov/gene/2313 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000543 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA FMR1 http://www.ncbi.nlm.nih.gov/gene/2332 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000544 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA FNDC3B http://www.ncbi.nlm.nih.gov/gene/64778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000545 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA FNIP1 http://www.ncbi.nlm.nih.gov/gene/96459 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000546 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA FUBP1 http://www.ncbi.nlm.nih.gov/gene/8880 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000547 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA GALNT5 http://www.ncbi.nlm.nih.gov/gene/11227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000548 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA GNPTAB http://www.ncbi.nlm.nih.gov/gene/79158 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000549 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA HSPA9 http://www.ncbi.nlm.nih.gov/gene/3313 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000550 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA IGF1R http://www.ncbi.nlm.nih.gov/gene/3480 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000551 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA ISCA1 http://www.ncbi.nlm.nih.gov/gene/81689 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000552 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA KIAA1211 http://www.ncbi.nlm.nih.gov/gene/57482 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000553 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA KLHL15 http://www.ncbi.nlm.nih.gov/gene/80311 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000554 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA KRAS http://www.ncbi.nlm.nih.gov/gene/3845 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000555 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA LRRC58 http://www.ncbi.nlm.nih.gov/gene/116064 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000556 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA MIER1 http://www.ncbi.nlm.nih.gov/gene/57708 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000557 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA MN1 http://www.ncbi.nlm.nih.gov/gene/4330 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000558 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA NBR1 http://www.ncbi.nlm.nih.gov/gene/4077 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000559 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA NIPA1 http://www.ncbi.nlm.nih.gov/gene/123606 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000560 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA NUCKS1 http://www.ncbi.nlm.nih.gov/gene/64710 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000561 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA PCBP2 http://www.ncbi.nlm.nih.gov/gene/5094 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000562 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA POLI http://www.ncbi.nlm.nih.gov/gene/11201 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000563 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA POU2F1 http://www.ncbi.nlm.nih.gov/gene/5451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000564 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA PPAP2B http://www.ncbi.nlm.nih.gov/gene/8613 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000565 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA PUM2 http://www.ncbi.nlm.nih.gov/gene/23369 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000566 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA RBM12 http://www.ncbi.nlm.nih.gov/gene/10137 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000567 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA RBM12B http://www.ncbi.nlm.nih.gov/gene/389677 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000568 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA RNF125 http://www.ncbi.nlm.nih.gov/gene/54941 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000569 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA RPRD2 http://www.ncbi.nlm.nih.gov/gene/23248 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000570 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA RSRC1 http://www.ncbi.nlm.nih.gov/gene/51319 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000571 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA SACM1L http://www.ncbi.nlm.nih.gov/gene/22908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000572 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA SENP5 http://www.ncbi.nlm.nih.gov/gene/205564 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000573 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA SETD8 http://www.ncbi.nlm.nih.gov/gene/387893 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000574 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA SLC19A2 http://www.ncbi.nlm.nih.gov/gene/10560 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000575 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA SMEK1 http://www.ncbi.nlm.nih.gov/gene/55671 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000576 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA SMG1 http://www.ncbi.nlm.nih.gov/gene/23049 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000577 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA SNTB2 http://www.ncbi.nlm.nih.gov/gene/6645 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000578 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA SPAST http://www.ncbi.nlm.nih.gov/gene/6683 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000579 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA SPOPL http://www.ncbi.nlm.nih.gov/gene/339745 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000580 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA SRP14 http://www.ncbi.nlm.nih.gov/gene/390284 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000581 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA TGFBR3 http://www.ncbi.nlm.nih.gov/gene/7049 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000582 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA TRAF3IP1 http://www.ncbi.nlm.nih.gov/gene/26146 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000583 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA TSN http://www.ncbi.nlm.nih.gov/gene/7247 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000584 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA TWISTNB http://www.ncbi.nlm.nih.gov/gene/221830 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000585 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA UBA6 http://www.ncbi.nlm.nih.gov/gene/55236 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000586 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA UGT8 http://www.ncbi.nlm.nih.gov/gene/7368 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000587 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA USP15 http://www.ncbi.nlm.nih.gov/gene/9958 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000588 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA WASF1 http://www.ncbi.nlm.nih.gov/gene/8936 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000589 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA WDR12 http://www.ncbi.nlm.nih.gov/gene/55759 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000590 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA ZNF226 http://www.ncbi.nlm.nih.gov/gene/7769 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000591 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA ZNF451 http://www.ncbi.nlm.nih.gov/gene/26036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000592 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA ZNF507 http://www.ncbi.nlm.nih.gov/gene/22847 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000593 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA ZNF627 http://www.ncbi.nlm.nih.gov/gene/199692 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000594 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(ebv-mir-bart17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 BC-1 - Host mRNA ZNF681 http://www.ncbi.nlm.nih.gov/gene/148213 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000595 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA AASDHPPT http://www.ncbi.nlm.nih.gov/gene/60496 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000596 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ABL2 http://www.ncbi.nlm.nih.gov/gene/27 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000597 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ADAR http://www.ncbi.nlm.nih.gov/gene/103 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000598 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA AMD1 http://www.ncbi.nlm.nih.gov/gene/262 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000599 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA AMMECR1L http://www.ncbi.nlm.nih.gov/gene/83607 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000600 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA AP1G1 http://www.ncbi.nlm.nih.gov/gene/164 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000601 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA APC http://www.ncbi.nlm.nih.gov/gene/324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000602 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ARF1 http://www.ncbi.nlm.nih.gov/gene/375 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000603 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ARID1A http://www.ncbi.nlm.nih.gov/gene/8289 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000604 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ARID4B http://www.ncbi.nlm.nih.gov/gene/51742 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000605 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ARL4C http://www.ncbi.nlm.nih.gov/gene/10123 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000606 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ARL6IP1 http://www.ncbi.nlm.nih.gov/gene/23204 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000607 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ASCC2 http://www.ncbi.nlm.nih.gov/gene/84164 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000608 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ATF2 http://www.ncbi.nlm.nih.gov/gene/1386 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000609 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ATF7IP http://www.ncbi.nlm.nih.gov/gene/55729 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000610 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ATXN10 http://www.ncbi.nlm.nih.gov/gene/25814 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000611 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA BAP1 http://www.ncbi.nlm.nih.gov/gene/8314 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000612 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA BRCA1 http://www.ncbi.nlm.nih.gov/gene/672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000613 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA BRMS1L http://www.ncbi.nlm.nih.gov/gene/84312 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000614 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA BRPF3 http://www.ncbi.nlm.nih.gov/gene/27154 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000615 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA BUB3 http://www.ncbi.nlm.nih.gov/gene/9184 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000616 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA C11orf57 http://www.ncbi.nlm.nih.gov/gene/55216 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000617 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA C14orf1 http://www.ncbi.nlm.nih.gov/gene/11161 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000618 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA C1orf2 http://www.ncbi.nlm.nih.gov/gene/10712 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000619 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA C1orf55 http://www.ncbi.nlm.nih.gov/gene/163859 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000620 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA C2orf29 http://www.ncbi.nlm.nih.gov/gene/55571 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000621 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA C2orf49 http://www.ncbi.nlm.nih.gov/gene/79074 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000622 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA C5orf24 http://www.ncbi.nlm.nih.gov/gene/134553 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000623 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA C5orf51 http://www.ncbi.nlm.nih.gov/gene/285636 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000624 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA C7orf64 http://www.ncbi.nlm.nih.gov/gene/84060 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000625 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA C9orf5 http://www.ncbi.nlm.nih.gov/gene/23731 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000626 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA C9orf80 http://www.ncbi.nlm.nih.gov/gene/58493 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000627 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA CBX3 http://www.ncbi.nlm.nih.gov/gene/11335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000628 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA CCND2 http://www.ncbi.nlm.nih.gov/gene/894 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000629 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA CCNG2 http://www.ncbi.nlm.nih.gov/gene/901 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000630 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA CD2AP http://www.ncbi.nlm.nih.gov/gene/23607 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000631 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA CERK http://www.ncbi.nlm.nih.gov/gene/64781 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000632 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA CLDND1 http://www.ncbi.nlm.nih.gov/gene/56650 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000633 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA CLEC2D http://www.ncbi.nlm.nih.gov/gene/29121 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000634 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA CNBP http://www.ncbi.nlm.nih.gov/gene/7555 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000635 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA CNOT6 http://www.ncbi.nlm.nih.gov/gene/57472 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000636 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA COPZ1 http://www.ncbi.nlm.nih.gov/gene/22818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000637 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA CPEB4 http://www.ncbi.nlm.nih.gov/gene/80315 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000638 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA CSNK1A1 http://www.ncbi.nlm.nih.gov/gene/1452 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000639 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA DDX6 http://www.ncbi.nlm.nih.gov/gene/1656 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000640 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA DICER1 http://www.ncbi.nlm.nih.gov/gene/23405 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000641 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA DMWD http://www.ncbi.nlm.nih.gov/gene/1762 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000642 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA DVL2 http://www.ncbi.nlm.nih.gov/gene/1856 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000643 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA EIF2AK1 http://www.ncbi.nlm.nih.gov/gene/27102 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000644 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA EMD http://www.ncbi.nlm.nih.gov/gene/2010 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000645 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ERLIN2 http://www.ncbi.nlm.nih.gov/gene/11160 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000646 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ETNK1 http://www.ncbi.nlm.nih.gov/gene/55500 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000647 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA EZH1 http://www.ncbi.nlm.nih.gov/gene/2145 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000648 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA FAM169A http://www.ncbi.nlm.nih.gov/gene/26049 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000649 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA FBXO45 http://www.ncbi.nlm.nih.gov/gene/200933 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000650 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA FBXO5 http://www.ncbi.nlm.nih.gov/gene/26271 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000651 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA FTO http://www.ncbi.nlm.nih.gov/gene/79068 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000652 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA FTSJD1 http://www.ncbi.nlm.nih.gov/gene/55783 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000653 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA GAN http://www.ncbi.nlm.nih.gov/gene/8139 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000654 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA GEMIN4 http://www.ncbi.nlm.nih.gov/gene/50628 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000655 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA GNAI2 http://www.ncbi.nlm.nih.gov/gene/2771 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000656 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA GNB1 http://www.ncbi.nlm.nih.gov/gene/2782 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000657 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA GNPTAB http://www.ncbi.nlm.nih.gov/gene/79158 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000658 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA GORASP2 http://www.ncbi.nlm.nih.gov/gene/26003 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000659 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA GOSR1 http://www.ncbi.nlm.nih.gov/gene/9527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000660 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA GOT2 http://www.ncbi.nlm.nih.gov/gene/2806 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000661 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA GPN1 http://www.ncbi.nlm.nih.gov/gene/11321 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000662 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA GRB2 http://www.ncbi.nlm.nih.gov/gene/2885 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000663 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA GRPEL2 http://www.ncbi.nlm.nih.gov/gene/134266 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000664 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA GTF2A2 http://www.ncbi.nlm.nih.gov/gene/2958 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000665 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA GTPBP1 http://www.ncbi.nlm.nih.gov/gene/9567 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000666 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA HECTD2 http://www.ncbi.nlm.nih.gov/gene/143279 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000667 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA HIP1 http://www.ncbi.nlm.nih.gov/gene/3092 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000668 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA HNRNPR http://www.ncbi.nlm.nih.gov/gene/10236 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000669 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA HNRPLL http://www.ncbi.nlm.nih.gov/gene/92906 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000670 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA HOOK1 http://www.ncbi.nlm.nih.gov/gene/51361 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000671 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA HSPBAP1 http://www.ncbi.nlm.nih.gov/gene/79663 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000672 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA IFT74 http://www.ncbi.nlm.nih.gov/gene/80173 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000673 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA IKBKB http://www.ncbi.nlm.nih.gov/gene/3551 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000674 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA IL15 http://www.ncbi.nlm.nih.gov/gene/3600 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000675 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA IPMK http://www.ncbi.nlm.nih.gov/gene/253430 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000676 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA IPO5 http://www.ncbi.nlm.nih.gov/gene/3843 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000677 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA IREB2 http://www.ncbi.nlm.nih.gov/gene/3658 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000678 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA IRF4 http://www.ncbi.nlm.nih.gov/gene/3662 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000679 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA IRF9 http://www.ncbi.nlm.nih.gov/gene/10379 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000680 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ISG20L2 http://www.ncbi.nlm.nih.gov/gene/81875 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000681 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA JMY http://www.ncbi.nlm.nih.gov/gene/133746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000682 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA KBTBD6 http://www.ncbi.nlm.nih.gov/gene/89890 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000683 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA KDM5C http://www.ncbi.nlm.nih.gov/gene/8242 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000684 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA KLHL24 http://www.ncbi.nlm.nih.gov/gene/54800 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000685 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA KPNA6 http://www.ncbi.nlm.nih.gov/gene/23633 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000686 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA LAMC1 http://www.ncbi.nlm.nih.gov/gene/3915 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000687 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA LIN52 http://www.ncbi.nlm.nih.gov/gene/91750 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000688 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA MAGT1 http://www.ncbi.nlm.nih.gov/gene/84061 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000689 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA MAZ http://www.ncbi.nlm.nih.gov/gene/4150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000690 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA MDM4 http://www.ncbi.nlm.nih.gov/gene/4194 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000691 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA MDN1 http://www.ncbi.nlm.nih.gov/gene/23195 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000692 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA MED26 http://www.ncbi.nlm.nih.gov/gene/9441 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000693 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA MFSD9 http://www.ncbi.nlm.nih.gov/gene/84804 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000694 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA MINK1 http://www.ncbi.nlm.nih.gov/gene/50488 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000695 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA MRPL45 http://www.ncbi.nlm.nih.gov/gene/84311 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000696 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA NARS http://www.ncbi.nlm.nih.gov/gene/4677 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000697 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA NCK1 http://www.ncbi.nlm.nih.gov/gene/4690 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000698 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA NCOA4 http://www.ncbi.nlm.nih.gov/gene/8031 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000699 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA NDRG1 http://www.ncbi.nlm.nih.gov/gene/10397 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000700 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA NF2 http://www.ncbi.nlm.nih.gov/gene/4771 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000701 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA NHLRC2 http://www.ncbi.nlm.nih.gov/gene/374354 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000702 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA NIPA1 http://www.ncbi.nlm.nih.gov/gene/123606 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000703 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA NOTCH2 http://www.ncbi.nlm.nih.gov/gene/4853 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000704 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA NUCKS1 http://www.ncbi.nlm.nih.gov/gene/64710 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000705 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA NUP155 http://www.ncbi.nlm.nih.gov/gene/9631 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000706 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA NUP160 http://www.ncbi.nlm.nih.gov/gene/23279 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000707 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA NVL http://www.ncbi.nlm.nih.gov/gene/4931 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000708 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA OTUD6B http://www.ncbi.nlm.nih.gov/gene/51633 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000709 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA PAICS http://www.ncbi.nlm.nih.gov/gene/10606 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000710 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA PARP14 http://www.ncbi.nlm.nih.gov/gene/54625 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000711 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA PBXIP1 http://www.ncbi.nlm.nih.gov/gene/57326 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000712 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA PI4KB http://www.ncbi.nlm.nih.gov/gene/5298 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000713 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA PIKFYVE http://www.ncbi.nlm.nih.gov/gene/200576 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000714 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA PJA2 http://www.ncbi.nlm.nih.gov/gene/9867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000715 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA PNN http://www.ncbi.nlm.nih.gov/gene/5411 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000716 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA POGK http://www.ncbi.nlm.nih.gov/gene/57645 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000717 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA POLE3 http://www.ncbi.nlm.nih.gov/gene/54107 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000718 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA PPP1R12A http://www.ncbi.nlm.nih.gov/gene/4659 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000719 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA PPP1R15B http://www.ncbi.nlm.nih.gov/gene/84919 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000720 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA PPP2R2A http://www.ncbi.nlm.nih.gov/gene/5520 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000721 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA PRDM15 http://www.ncbi.nlm.nih.gov/gene/63977 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000722 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA PURB http://www.ncbi.nlm.nih.gov/gene/5814 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000723 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA PXK http://www.ncbi.nlm.nih.gov/gene/54899 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000724 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA PYGO2 http://www.ncbi.nlm.nih.gov/gene/90780 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000725 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA RAD18 http://www.ncbi.nlm.nih.gov/gene/56852 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000726 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA RBM18 http://www.ncbi.nlm.nih.gov/gene/92400 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000727 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA REPIN1 http://www.ncbi.nlm.nih.gov/gene/29803 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000728 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA REST http://www.ncbi.nlm.nih.gov/gene/5978 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000729 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA RNF168 http://www.ncbi.nlm.nih.gov/gene/165918 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000730 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA RPL22 http://www.ncbi.nlm.nih.gov/gene/402100 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000731 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA RPL31 http://www.ncbi.nlm.nih.gov/gene/653773 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000732 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA RRN3 http://www.ncbi.nlm.nih.gov/gene/54700 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000733 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA SAMD9 http://www.ncbi.nlm.nih.gov/gene/54809 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000734 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA SCYL2 http://www.ncbi.nlm.nih.gov/gene/55681 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000735 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA SDF2 http://www.ncbi.nlm.nih.gov/gene/6388 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000736 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA SETD8 http://www.ncbi.nlm.nih.gov/gene/387893 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000737 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA SF3A3 http://www.ncbi.nlm.nih.gov/gene/10946 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000738 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA SGOL1 http://www.ncbi.nlm.nih.gov/gene/151648 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000739 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA SH3BGRL http://www.ncbi.nlm.nih.gov/gene/6451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000740 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA SH3GL2 http://www.ncbi.nlm.nih.gov/gene/6456 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000741 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA SIDT1 http://www.ncbi.nlm.nih.gov/gene/54847 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000742 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA SLC39A14 http://www.ncbi.nlm.nih.gov/gene/23516 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000743 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA SLC7A6 http://www.ncbi.nlm.nih.gov/gene/9057 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000744 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA SLMAP http://www.ncbi.nlm.nih.gov/gene/7871 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000745 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA SMAD4 http://www.ncbi.nlm.nih.gov/gene/4089 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000746 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA SMG7 http://www.ncbi.nlm.nih.gov/gene/9887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000747 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA SNIP1 http://www.ncbi.nlm.nih.gov/gene/79753 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000748 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA SNX12 http://www.ncbi.nlm.nih.gov/gene/29934 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000749 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA SNX25 http://www.ncbi.nlm.nih.gov/gene/83891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000750 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA SPATA2 http://www.ncbi.nlm.nih.gov/gene/9825 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000751 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA SRPK1 http://www.ncbi.nlm.nih.gov/gene/6732 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000752 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA SSR1 http://www.ncbi.nlm.nih.gov/gene/6745 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000753 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA TBC1D20 http://www.ncbi.nlm.nih.gov/gene/128637 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000754 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA TM9SF3 http://www.ncbi.nlm.nih.gov/gene/56889 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000755 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA TMEM194A http://www.ncbi.nlm.nih.gov/gene/23306 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000756 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA TMEM39A http://www.ncbi.nlm.nih.gov/gene/55254 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000757 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA TMTC3 http://www.ncbi.nlm.nih.gov/gene/160418 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000758 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA TRIB1 http://www.ncbi.nlm.nih.gov/gene/10221 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000759 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA TRIM24 http://www.ncbi.nlm.nih.gov/gene/8805 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000760 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA TRIP6 http://www.ncbi.nlm.nih.gov/gene/7205 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000761 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA TSPYL5 http://www.ncbi.nlm.nih.gov/gene/85453 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000762 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA TST http://www.ncbi.nlm.nih.gov/gene/7263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000763 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA TUBB http://www.ncbi.nlm.nih.gov/gene/647000 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000764 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA UBAC2 http://www.ncbi.nlm.nih.gov/gene/337867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000765 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA UBE2N http://www.ncbi.nlm.nih.gov/gene/7334 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000766 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA UBFD1 http://www.ncbi.nlm.nih.gov/gene/56061 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000767 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA UHRF2 http://www.ncbi.nlm.nih.gov/gene/115426 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000768 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA USP38 http://www.ncbi.nlm.nih.gov/gene/84640 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000769 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA USP49 http://www.ncbi.nlm.nih.gov/gene/25862 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000770 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA VAMP4 http://www.ncbi.nlm.nih.gov/gene/8674 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000771 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA VAMP8 http://www.ncbi.nlm.nih.gov/gene/8673 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000772 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA VEZT http://www.ncbi.nlm.nih.gov/gene/55591 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000773 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA VPS37A http://www.ncbi.nlm.nih.gov/gene/137492 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000774 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA WAC http://www.ncbi.nlm.nih.gov/gene/51322 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000775 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA WASL http://www.ncbi.nlm.nih.gov/gene/8976 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000776 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA WNK1 http://www.ncbi.nlm.nih.gov/gene/65125 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000777 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA YES1 http://www.ncbi.nlm.nih.gov/gene/7525 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000778 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA YWHAG http://www.ncbi.nlm.nih.gov/gene/7532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000779 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ZBTB5 http://www.ncbi.nlm.nih.gov/gene/9925 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000780 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ZDHHC5 http://www.ncbi.nlm.nih.gov/gene/25921 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000781 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ZFP36L1 http://www.ncbi.nlm.nih.gov/gene/677 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000782 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ZNF2 http://www.ncbi.nlm.nih.gov/gene/7549 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000783 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ZNF525 http://www.ncbi.nlm.nih.gov/gene/170958 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000784 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ZNF626 http://www.ncbi.nlm.nih.gov/gene/199777 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000785 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ZNF644 http://www.ncbi.nlm.nih.gov/gene/84146 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000786 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ZNF805 http://www.ncbi.nlm.nih.gov/gene/390980 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000787 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ZNRF2 http://www.ncbi.nlm.nih.gov/gene/223082 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000788 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(ebv-mir-bart17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 BC-1 - Host mRNA ZZZ3 http://www.ncbi.nlm.nih.gov/gene/26009 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000789 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-3p(ebv-mir-bart18-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004835 BC-1 - Host mRNA ADCY3 http://www.ncbi.nlm.nih.gov/gene/109 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000790 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-3p(ebv-mir-bart18-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004835 BC-1 - Host mRNA ADIPOR2 http://www.ncbi.nlm.nih.gov/gene/79602 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000791 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-3p(ebv-mir-bart18-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004835 BC-1 - Host mRNA CFLAR http://www.ncbi.nlm.nih.gov/gene/8837 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000792 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-3p(ebv-mir-bart18-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004835 BC-1 - Host mRNA JMY http://www.ncbi.nlm.nih.gov/gene/133746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000793 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-3p(ebv-mir-bart18-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004835 BC-1 - Host mRNA LYPLA2 http://www.ncbi.nlm.nih.gov/gene/11313 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000794 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-3p(ebv-mir-bart18-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004835 BC-1 - Host mRNA MDM4 http://www.ncbi.nlm.nih.gov/gene/4194 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000795 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-3p(ebv-mir-bart18-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004835 BC-1 - Host mRNA MTMR9 http://www.ncbi.nlm.nih.gov/gene/66036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000796 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-3p(ebv-mir-bart18-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004835 BC-1 - Host mRNA MVK http://www.ncbi.nlm.nih.gov/gene/4598 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000797 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-3p(ebv-mir-bart18-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004835 BC-1 - Host mRNA UBXN2A http://www.ncbi.nlm.nih.gov/gene/165324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000798 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-3p(ebv-mir-bart18-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004835 BC-1 - Host mRNA UPF3B http://www.ncbi.nlm.nih.gov/gene/65109 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000799 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA ACBD5 http://www.ncbi.nlm.nih.gov/gene/91452 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000800 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA ACPL2 http://www.ncbi.nlm.nih.gov/gene/92370 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000801 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA ADAM17 http://www.ncbi.nlm.nih.gov/gene/6868 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000802 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA ADCY7 http://www.ncbi.nlm.nih.gov/gene/113 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000803 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA AFF1 http://www.ncbi.nlm.nih.gov/gene/4299 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000804 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA AGFG1 http://www.ncbi.nlm.nih.gov/gene/3267 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000805 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA ALDH9A1 http://www.ncbi.nlm.nih.gov/gene/223 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000806 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA ALG2 http://www.ncbi.nlm.nih.gov/gene/85365 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000807 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA ANKMY2 http://www.ncbi.nlm.nih.gov/gene/57037 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000808 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA ARL1 http://www.ncbi.nlm.nih.gov/gene/400 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000809 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA ARL6IP5 http://www.ncbi.nlm.nih.gov/gene/10550 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000810 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA ATE1 http://www.ncbi.nlm.nih.gov/gene/11101 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000811 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA ATL2 http://www.ncbi.nlm.nih.gov/gene/64225 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000812 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA ATP6V1A http://www.ncbi.nlm.nih.gov/gene/523 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000813 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA BNIP1 http://www.ncbi.nlm.nih.gov/gene/662 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000814 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA BRWD1 http://www.ncbi.nlm.nih.gov/gene/54014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000815 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA C19orf43 http://www.ncbi.nlm.nih.gov/gene/79002 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000816 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA C6orf204 http://www.ncbi.nlm.nih.gov/gene/387119 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000817 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA C9orf41 http://www.ncbi.nlm.nih.gov/gene/138199 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000818 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA CASP3 http://www.ncbi.nlm.nih.gov/gene/836 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000819 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA CDC73 http://www.ncbi.nlm.nih.gov/gene/79577 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000820 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA CDKN3 http://www.ncbi.nlm.nih.gov/gene/1033 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000821 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA CDS2 http://www.ncbi.nlm.nih.gov/gene/8760 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000822 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA CEP55 http://www.ncbi.nlm.nih.gov/gene/55165 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000823 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA CNOT1 http://www.ncbi.nlm.nih.gov/gene/23019 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000824 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA COPA http://www.ncbi.nlm.nih.gov/gene/1314 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000825 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA COPS2 http://www.ncbi.nlm.nih.gov/gene/9318 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000826 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA COPS7B http://www.ncbi.nlm.nih.gov/gene/64708 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000827 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA CPEB3 http://www.ncbi.nlm.nih.gov/gene/22849 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000828 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA CPEB4 http://www.ncbi.nlm.nih.gov/gene/80315 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000829 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA CREBBP http://www.ncbi.nlm.nih.gov/gene/1387 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000830 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA DARS http://www.ncbi.nlm.nih.gov/gene/1615 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000831 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA DCAF7 http://www.ncbi.nlm.nih.gov/gene/10238 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000832 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA DDX3X http://www.ncbi.nlm.nih.gov/gene/1654 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000833 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA DDX3Y http://www.ncbi.nlm.nih.gov/gene/8653 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000834 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA DENND1B http://www.ncbi.nlm.nih.gov/gene/163486 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000835 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA DPP8 http://www.ncbi.nlm.nih.gov/gene/54878 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000836 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA DYRK1A http://www.ncbi.nlm.nih.gov/gene/1859 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000837 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA EXOC8 http://www.ncbi.nlm.nih.gov/gene/149371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000838 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA EYA3 http://www.ncbi.nlm.nih.gov/gene/2140 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000839 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA FAM108C1 http://www.ncbi.nlm.nih.gov/gene/58489 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000840 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA FAM160A2 http://www.ncbi.nlm.nih.gov/gene/84067 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000841 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA FAM46C http://www.ncbi.nlm.nih.gov/gene/54855 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000842 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA FAM73A http://www.ncbi.nlm.nih.gov/gene/374986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000843 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA FBXO28 http://www.ncbi.nlm.nih.gov/gene/23219 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000844 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA GDI2 http://www.ncbi.nlm.nih.gov/gene/2665 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000845 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA GNPNAT1 http://www.ncbi.nlm.nih.gov/gene/64841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000846 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA GORASP2 http://www.ncbi.nlm.nih.gov/gene/26003 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000847 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA HIPK2 http://www.ncbi.nlm.nih.gov/gene/653052 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000848 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA HMBOX1 http://www.ncbi.nlm.nih.gov/gene/79618 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000849 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA HNRNPUL1 http://www.ncbi.nlm.nih.gov/gene/11100 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000850 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA HOMER1 http://www.ncbi.nlm.nih.gov/gene/9456 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000851 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA KANK1 http://www.ncbi.nlm.nih.gov/gene/23189 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000852 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA KAT2B http://www.ncbi.nlm.nih.gov/gene/8850 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000853 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA KIAA0947 http://www.ncbi.nlm.nih.gov/gene/23379 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000854 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA KLHL15 http://www.ncbi.nlm.nih.gov/gene/80311 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000855 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA KLHL20 http://www.ncbi.nlm.nih.gov/gene/27252 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000856 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA LANCL1 http://www.ncbi.nlm.nih.gov/gene/10314 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000857 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA LARP4B http://www.ncbi.nlm.nih.gov/gene/23185 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000858 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA LIN7C http://www.ncbi.nlm.nih.gov/gene/55327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000859 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA LIX1L http://www.ncbi.nlm.nih.gov/gene/128077 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000860 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA LRCH1 http://www.ncbi.nlm.nih.gov/gene/23143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000861 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA LSM8 http://www.ncbi.nlm.nih.gov/gene/51691 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000862 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA LUC7L2 http://www.ncbi.nlm.nih.gov/gene/51631 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000863 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA MACF1 http://www.ncbi.nlm.nih.gov/gene/23499 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000864 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA MAP3K13 http://www.ncbi.nlm.nih.gov/gene/9175 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000865 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA MAPK1IP1L http://www.ncbi.nlm.nih.gov/gene/93487 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000866 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA MBLAC2 http://www.ncbi.nlm.nih.gov/gene/153364 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000867 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA MCL1 http://www.ncbi.nlm.nih.gov/gene/4170 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000868 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA MED29 http://www.ncbi.nlm.nih.gov/gene/55588 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000869 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA MEX3C http://www.ncbi.nlm.nih.gov/gene/51320 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000870 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA MGAT5 http://www.ncbi.nlm.nih.gov/gene/151162 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000871 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA MLLT10 http://www.ncbi.nlm.nih.gov/gene/8028 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000872 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA MRE11A http://www.ncbi.nlm.nih.gov/gene/4361 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000873 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA MTPN http://www.ncbi.nlm.nih.gov/gene/767558 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000874 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA MYC http://www.ncbi.nlm.nih.gov/gene/4609 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000875 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA NAB1 http://www.ncbi.nlm.nih.gov/gene/4664 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000876 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA NAPB http://www.ncbi.nlm.nih.gov/gene/63908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000877 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA NFAT5 http://www.ncbi.nlm.nih.gov/gene/10725 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000878 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA NUCKS1 http://www.ncbi.nlm.nih.gov/gene/64710 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000879 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA NUFIP2 http://www.ncbi.nlm.nih.gov/gene/57532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000880 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA NUP153 http://www.ncbi.nlm.nih.gov/gene/9972 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000881 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA NUPL1 http://www.ncbi.nlm.nih.gov/gene/9818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000882 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA OTUD4 http://www.ncbi.nlm.nih.gov/gene/54726 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000883 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA OTUD6B http://www.ncbi.nlm.nih.gov/gene/51633 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000884 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA PDE12 http://www.ncbi.nlm.nih.gov/gene/201626 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000885 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA PDE7A http://www.ncbi.nlm.nih.gov/gene/5150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000886 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA PDPR http://www.ncbi.nlm.nih.gov/gene/55066 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000887 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA PHF20L1 http://www.ncbi.nlm.nih.gov/gene/51105 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000888 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA PIK3R1 http://www.ncbi.nlm.nih.gov/gene/5295 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000889 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA PIM1 http://www.ncbi.nlm.nih.gov/gene/5292 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000890 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA PKD2 http://www.ncbi.nlm.nih.gov/gene/5311 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000891 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA PPP1CC http://www.ncbi.nlm.nih.gov/gene/5501 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000892 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA PPP1R15B http://www.ncbi.nlm.nih.gov/gene/84919 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000893 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA PPTC7 http://www.ncbi.nlm.nih.gov/gene/160760 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000894 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA PSMC2 http://www.ncbi.nlm.nih.gov/gene/5701 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000895 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA PURB http://www.ncbi.nlm.nih.gov/gene/5814 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000896 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA QSER1 http://www.ncbi.nlm.nih.gov/gene/79832 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000897 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA RAB11A http://www.ncbi.nlm.nih.gov/gene/8766 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000898 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA RAB11FIP1 http://www.ncbi.nlm.nih.gov/gene/80223 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000899 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA RANBP6 http://www.ncbi.nlm.nih.gov/gene/26953 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000900 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA RNF111 http://www.ncbi.nlm.nih.gov/gene/54778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000901 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA RNF141 http://www.ncbi.nlm.nih.gov/gene/50862 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000902 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA RORA http://www.ncbi.nlm.nih.gov/gene/6095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000903 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA RSRC2 http://www.ncbi.nlm.nih.gov/gene/65117 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000904 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA SCD http://www.ncbi.nlm.nih.gov/gene/6319 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000905 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA SERP1 http://www.ncbi.nlm.nih.gov/gene/27230 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000906 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA SETD7 http://www.ncbi.nlm.nih.gov/gene/80854 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000907 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA SLC16A6 http://www.ncbi.nlm.nih.gov/gene/9120 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000908 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA SLC19A2 http://www.ncbi.nlm.nih.gov/gene/10560 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000909 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA SMNDC1 http://www.ncbi.nlm.nih.gov/gene/10285 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000910 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA SP4 http://www.ncbi.nlm.nih.gov/gene/6671 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000911 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA SPATS2 http://www.ncbi.nlm.nih.gov/gene/65244 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000912 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA SPTBN1 http://www.ncbi.nlm.nih.gov/gene/6711 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000913 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA SSFA2 http://www.ncbi.nlm.nih.gov/gene/6744 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000914 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA STARD4 http://www.ncbi.nlm.nih.gov/gene/134429 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000915 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA STYX http://www.ncbi.nlm.nih.gov/gene/6815 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000916 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA TET1 http://www.ncbi.nlm.nih.gov/gene/80312 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000917 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA TET2 http://www.ncbi.nlm.nih.gov/gene/54790 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000918 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA TFRC http://www.ncbi.nlm.nih.gov/gene/7037 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000919 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA THAP11 http://www.ncbi.nlm.nih.gov/gene/57215 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000920 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA TMF1 http://www.ncbi.nlm.nih.gov/gene/7110 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000921 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA TOLLIP http://www.ncbi.nlm.nih.gov/gene/54472 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000922 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA TP53INP1 http://www.ncbi.nlm.nih.gov/gene/94241 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000923 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA TPR http://www.ncbi.nlm.nih.gov/gene/7175 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000924 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA TRIB1 http://www.ncbi.nlm.nih.gov/gene/10221 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000925 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA TRIM65 http://www.ncbi.nlm.nih.gov/gene/201292 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000926 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA TXNDC12 http://www.ncbi.nlm.nih.gov/gene/51060 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000927 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA UBN2 http://www.ncbi.nlm.nih.gov/gene/254048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000928 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA UBR3 http://www.ncbi.nlm.nih.gov/gene/130507 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000929 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA USP33 http://www.ncbi.nlm.nih.gov/gene/23032 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000930 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA USP37 http://www.ncbi.nlm.nih.gov/gene/57695 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000931 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA VDAC1 http://www.ncbi.nlm.nih.gov/gene/7416 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000932 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA WAC http://www.ncbi.nlm.nih.gov/gene/51322 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000933 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA WDR12 http://www.ncbi.nlm.nih.gov/gene/55759 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000934 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA XPO4 http://www.ncbi.nlm.nih.gov/gene/64328 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000935 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA YTHDC2 http://www.ncbi.nlm.nih.gov/gene/64848 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000936 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA YWHAE http://www.ncbi.nlm.nih.gov/gene/7531 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000937 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA ZC3H14 http://www.ncbi.nlm.nih.gov/gene/79882 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000938 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA ZFX http://www.ncbi.nlm.nih.gov/gene/7543 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000939 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA ZNF12 http://www.ncbi.nlm.nih.gov/gene/7559 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000940 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA ZNF217 http://www.ncbi.nlm.nih.gov/gene/7764 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000941 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA ZNF238 http://www.ncbi.nlm.nih.gov/gene/10472 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000942 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA ZNF295 http://www.ncbi.nlm.nih.gov/gene/49854 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000943 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA ZNF518A http://www.ncbi.nlm.nih.gov/gene/9849 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000944 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA ZNF706 http://www.ncbi.nlm.nih.gov/gene/51123 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000945 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART18-5p(ebv-mir-bart18-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003717 BC-1 - Host mRNA ZNHIT3 http://www.ncbi.nlm.nih.gov/gene/9326 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000946 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MARCH6 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000947 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MARCH8 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000948 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA AASDHPPT http://www.ncbi.nlm.nih.gov/gene/60496 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000949 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ABI1 http://www.ncbi.nlm.nih.gov/gene/10006 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000950 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ACOT9 http://www.ncbi.nlm.nih.gov/gene/23597 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000951 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ACPL2 http://www.ncbi.nlm.nih.gov/gene/92370 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000952 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ACSL4 http://www.ncbi.nlm.nih.gov/gene/2182 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000953 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ADAM10 http://www.ncbi.nlm.nih.gov/gene/102 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000954 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ADCY9 http://www.ncbi.nlm.nih.gov/gene/115 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000955 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ADIPOR2 http://www.ncbi.nlm.nih.gov/gene/79602 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000956 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA AEBP2 http://www.ncbi.nlm.nih.gov/gene/121536 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000957 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA AFF1 http://www.ncbi.nlm.nih.gov/gene/4299 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000958 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA AFF4 http://www.ncbi.nlm.nih.gov/gene/27125 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000959 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA AGPAT3 http://www.ncbi.nlm.nih.gov/gene/56894 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000960 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA AHNAK http://www.ncbi.nlm.nih.gov/gene/79026 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000961 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA AKIRIN1 http://www.ncbi.nlm.nih.gov/gene/79647 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000962 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ALDH3A2 http://www.ncbi.nlm.nih.gov/gene/224 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000963 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ALG10 http://www.ncbi.nlm.nih.gov/gene/84920 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000964 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ANGEL2 http://www.ncbi.nlm.nih.gov/gene/90806 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000965 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ANKFY1 http://www.ncbi.nlm.nih.gov/gene/51479 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000966 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ANKRD50 http://www.ncbi.nlm.nih.gov/gene/57182 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000967 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ANP32E http://www.ncbi.nlm.nih.gov/gene/81611 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000968 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA AP1GBP1 http://www.ncbi.nlm.nih.gov/gene/11276 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000969 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA APC http://www.ncbi.nlm.nih.gov/gene/324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000970 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA APPBP2 http://www.ncbi.nlm.nih.gov/gene/10513 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000971 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ARFGEF2 http://www.ncbi.nlm.nih.gov/gene/10564 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000972 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ARID4B http://www.ncbi.nlm.nih.gov/gene/51742 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000973 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ARIH1 http://www.ncbi.nlm.nih.gov/gene/25820 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000974 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ARL5A http://www.ncbi.nlm.nih.gov/gene/26225 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000975 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ARL6IP5 http://www.ncbi.nlm.nih.gov/gene/10550 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000976 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ARPC2 http://www.ncbi.nlm.nih.gov/gene/10109 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000977 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ARPP-21 http://www.ncbi.nlm.nih.gov/gene/10777 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000978 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ARRDC3 http://www.ncbi.nlm.nih.gov/gene/57561 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000979 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ASH1L http://www.ncbi.nlm.nih.gov/gene/55870 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000980 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ATG2B http://www.ncbi.nlm.nih.gov/gene/55102 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000981 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ATP11B http://www.ncbi.nlm.nih.gov/gene/23200 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000982 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ATP2B4 http://www.ncbi.nlm.nih.gov/gene/493 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000983 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ATP6V1A http://www.ncbi.nlm.nih.gov/gene/523 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000984 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ATP6V1B2 http://www.ncbi.nlm.nih.gov/gene/526 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000985 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ATXN1 http://www.ncbi.nlm.nih.gov/gene/6310 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000986 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA AVL9 http://www.ncbi.nlm.nih.gov/gene/23080 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000987 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA AZIN1 http://www.ncbi.nlm.nih.gov/gene/51582 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000988 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA B4GALT6 http://www.ncbi.nlm.nih.gov/gene/9331 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000989 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA BARD1 http://www.ncbi.nlm.nih.gov/gene/580 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000990 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA BAT1 http://www.ncbi.nlm.nih.gov/gene/7919 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000991 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA BAZ2B http://www.ncbi.nlm.nih.gov/gene/29994 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000992 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA BBX http://www.ncbi.nlm.nih.gov/gene/56987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000993 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA BCL11A http://www.ncbi.nlm.nih.gov/gene/53335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000994 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA BCL9 http://www.ncbi.nlm.nih.gov/gene/607 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000995 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA BNC2 http://www.ncbi.nlm.nih.gov/gene/54796 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000996 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA BPTF http://www.ncbi.nlm.nih.gov/gene/2186 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000997 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA BRAF http://www.ncbi.nlm.nih.gov/gene/673 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000998 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA BRCA1 http://www.ncbi.nlm.nih.gov/gene/672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00000999 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA BRPF3 http://www.ncbi.nlm.nih.gov/gene/27154 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001000 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA BRWD1 http://www.ncbi.nlm.nih.gov/gene/54014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001001 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA BTG2 http://www.ncbi.nlm.nih.gov/gene/7832 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001002 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA BZW1 http://www.ncbi.nlm.nih.gov/gene/391592 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001003 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C10orf84 http://www.ncbi.nlm.nih.gov/gene/63877 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001004 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C12orf4 http://www.ncbi.nlm.nih.gov/gene/283461 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001005 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C13orf37 http://www.ncbi.nlm.nih.gov/gene/440145 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001006 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C14orf129 http://www.ncbi.nlm.nih.gov/gene/51527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001007 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C14orf43 http://www.ncbi.nlm.nih.gov/gene/91748 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001008 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C16orf63 http://www.ncbi.nlm.nih.gov/gene/123811 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001009 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C17orf39 http://www.ncbi.nlm.nih.gov/gene/79018 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001010 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C1orf107 http://www.ncbi.nlm.nih.gov/gene/27042 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001011 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C1orf96 http://www.ncbi.nlm.nih.gov/gene/126731 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001012 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C20orf103 http://www.ncbi.nlm.nih.gov/gene/24141 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001013 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C20orf112 http://www.ncbi.nlm.nih.gov/gene/140688 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001014 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C20orf3 http://www.ncbi.nlm.nih.gov/gene/57136 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001015 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C21orf91 http://www.ncbi.nlm.nih.gov/gene/54149 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001016 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C2orf29 http://www.ncbi.nlm.nih.gov/gene/55571 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001017 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C2orf50 http://www.ncbi.nlm.nih.gov/gene/130813 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001018 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C3orf38 http://www.ncbi.nlm.nih.gov/gene/285237 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001019 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C3orf63 http://www.ncbi.nlm.nih.gov/gene/23272 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001020 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C3orf64 http://www.ncbi.nlm.nih.gov/gene/285203 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001021 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C5orf28 http://www.ncbi.nlm.nih.gov/gene/64417 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001022 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C5orf41 http://www.ncbi.nlm.nih.gov/gene/153222 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001023 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C6orf106 http://www.ncbi.nlm.nih.gov/gene/64771 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001024 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C6orf204 http://www.ncbi.nlm.nih.gov/gene/387119 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001025 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C6orf35 http://www.ncbi.nlm.nih.gov/gene/23331 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001026 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C7orf23 http://www.ncbi.nlm.nih.gov/gene/79161 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001027 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C7orf70 http://www.ncbi.nlm.nih.gov/gene/84792 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001028 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C8orf76 http://www.ncbi.nlm.nih.gov/gene/84933 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001029 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C9orf6 http://www.ncbi.nlm.nih.gov/gene/54942 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001030 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C9orf78 http://www.ncbi.nlm.nih.gov/gene/51759 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001031 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA C9orf80 http://www.ncbi.nlm.nih.gov/gene/58493 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001032 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CALCRL http://www.ncbi.nlm.nih.gov/gene/10203 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001033 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CALM1 http://www.ncbi.nlm.nih.gov/gene/808 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001034 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CALR http://www.ncbi.nlm.nih.gov/gene/811 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001035 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CAPN7 http://www.ncbi.nlm.nih.gov/gene/23473 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001036 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CBFB http://www.ncbi.nlm.nih.gov/gene/865 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001037 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CBX3 http://www.ncbi.nlm.nih.gov/gene/11335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001038 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CBX5 http://www.ncbi.nlm.nih.gov/gene/23468 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001039 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CCDC117 http://www.ncbi.nlm.nih.gov/gene/150275 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001040 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CCDC66 http://www.ncbi.nlm.nih.gov/gene/285331 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001041 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CCDC91 http://www.ncbi.nlm.nih.gov/gene/55297 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001042 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CCNG1 http://www.ncbi.nlm.nih.gov/gene/900 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001043 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001044 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CD164 http://www.ncbi.nlm.nih.gov/gene/8763 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001045 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CDC42 http://www.ncbi.nlm.nih.gov/gene/998 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001046 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CDC6 http://www.ncbi.nlm.nih.gov/gene/990 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001047 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CDKN1A http://www.ncbi.nlm.nih.gov/gene/1026 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001048 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CDS1 http://www.ncbi.nlm.nih.gov/gene/1040 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001049 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CEP110 http://www.ncbi.nlm.nih.gov/gene/11064 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001050 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CHD9 http://www.ncbi.nlm.nih.gov/gene/80205 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001051 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CHST15 http://www.ncbi.nlm.nih.gov/gene/51363 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001052 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CIC http://www.ncbi.nlm.nih.gov/gene/23152 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001053 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CLCN4 http://www.ncbi.nlm.nih.gov/gene/1183 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001054 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CLDN12 http://www.ncbi.nlm.nih.gov/gene/9069 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001055 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CLTC http://www.ncbi.nlm.nih.gov/gene/1213 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001056 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CMTM7 http://www.ncbi.nlm.nih.gov/gene/112616 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001057 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA COL24A1 http://www.ncbi.nlm.nih.gov/gene/255631 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001058 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA COL27A1 http://www.ncbi.nlm.nih.gov/gene/85301 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001059 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA COMMD2 http://www.ncbi.nlm.nih.gov/gene/51122 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001060 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA COMMD6 http://www.ncbi.nlm.nih.gov/gene/170622 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001061 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA COMMD7 http://www.ncbi.nlm.nih.gov/gene/149951 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001062 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA COPB1 http://www.ncbi.nlm.nih.gov/gene/1315 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001063 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA COPS2 http://www.ncbi.nlm.nih.gov/gene/9318 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001064 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA COX15 http://www.ncbi.nlm.nih.gov/gene/1355 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001065 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CPEB4 http://www.ncbi.nlm.nih.gov/gene/80315 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001066 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CSDE1 http://www.ncbi.nlm.nih.gov/gene/7812 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001067 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CSNK1A1 http://www.ncbi.nlm.nih.gov/gene/1452 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001068 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CSNK1G1 http://www.ncbi.nlm.nih.gov/gene/53944 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001069 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CSNK1G3 http://www.ncbi.nlm.nih.gov/gene/1456 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001070 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CUX1 http://www.ncbi.nlm.nih.gov/gene/1523 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001071 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CWC22 http://www.ncbi.nlm.nih.gov/gene/57703 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001072 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CXCR7 http://www.ncbi.nlm.nih.gov/gene/57007 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001073 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CYP2U1 http://www.ncbi.nlm.nih.gov/gene/113612 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001074 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA CYTIP http://www.ncbi.nlm.nih.gov/gene/9595 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001075 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA DCP1A http://www.ncbi.nlm.nih.gov/gene/55802 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001076 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA DCP2 http://www.ncbi.nlm.nih.gov/gene/167227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001077 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA DCUN1D1 http://www.ncbi.nlm.nih.gov/gene/54165 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001078 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA DDI2 http://www.ncbi.nlm.nih.gov/gene/84301 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001079 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA DDX3Y http://www.ncbi.nlm.nih.gov/gene/8653 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001080 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA DDX46 http://www.ncbi.nlm.nih.gov/gene/9879 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001081 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA DENND1B http://www.ncbi.nlm.nih.gov/gene/163486 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001082 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA DIP2C http://www.ncbi.nlm.nih.gov/gene/22982 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001083 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA DIXDC1 http://www.ncbi.nlm.nih.gov/gene/85458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001084 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA DLGAP4 http://www.ncbi.nlm.nih.gov/gene/22839 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001085 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA DMTF1 http://www.ncbi.nlm.nih.gov/gene/9988 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001086 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA DNM1L http://www.ncbi.nlm.nih.gov/gene/10059 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001087 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA DOLPP1 http://www.ncbi.nlm.nih.gov/gene/57171 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001088 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA DSG2 http://www.ncbi.nlm.nih.gov/gene/1829 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001089 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA DSTYK http://www.ncbi.nlm.nih.gov/gene/25778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001090 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA DUSP16 http://www.ncbi.nlm.nih.gov/gene/80824 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001091 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA DVL3 http://www.ncbi.nlm.nih.gov/gene/1857 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001092 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA DYNC1LI2 http://www.ncbi.nlm.nih.gov/gene/1783 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001093 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA DYNLL2 http://www.ncbi.nlm.nih.gov/gene/140735 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001094 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA DYRK1A http://www.ncbi.nlm.nih.gov/gene/1859 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001095 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA DYRK2 http://www.ncbi.nlm.nih.gov/gene/8445 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001096 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ECD http://www.ncbi.nlm.nih.gov/gene/11319 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001097 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA EDF1 http://www.ncbi.nlm.nih.gov/gene/8721 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001098 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA EGR1 http://www.ncbi.nlm.nih.gov/gene/1958 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001099 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA EIF2C4 http://www.ncbi.nlm.nih.gov/gene/192670 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001100 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA EIF2S1 http://www.ncbi.nlm.nih.gov/gene/1965 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001101 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA EIF3H http://www.ncbi.nlm.nih.gov/gene/8667 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001102 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA EIF3M http://www.ncbi.nlm.nih.gov/gene/10480 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001103 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA EIF4A1 http://www.ncbi.nlm.nih.gov/gene/728698 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001104 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA EIF4B http://www.ncbi.nlm.nih.gov/gene/1975 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001105 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA EIF4G2 http://www.ncbi.nlm.nih.gov/gene/1982 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001106 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA EIF5A2 http://www.ncbi.nlm.nih.gov/gene/56648 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001107 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ELK4 http://www.ncbi.nlm.nih.gov/gene/2005 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001108 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ENTPD4 http://www.ncbi.nlm.nih.gov/gene/9583 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001109 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA EPB41 http://www.ncbi.nlm.nih.gov/gene/2035 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001110 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA EPDR1 http://www.ncbi.nlm.nih.gov/gene/54749 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001111 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ERBB2IP http://www.ncbi.nlm.nih.gov/gene/55914 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001112 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ERC1 http://www.ncbi.nlm.nih.gov/gene/23085 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001113 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ERLIN2 http://www.ncbi.nlm.nih.gov/gene/11160 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001114 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ETV3 http://www.ncbi.nlm.nih.gov/gene/2117 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001115 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA EVI5 http://www.ncbi.nlm.nih.gov/gene/7813 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001116 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA EXOC6 http://www.ncbi.nlm.nih.gov/gene/54536 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001117 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA EYA4 http://www.ncbi.nlm.nih.gov/gene/2070 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001118 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FAM126A http://www.ncbi.nlm.nih.gov/gene/84668 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001119 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FAM126B http://www.ncbi.nlm.nih.gov/gene/285172 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001120 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FAM135A http://www.ncbi.nlm.nih.gov/gene/57579 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001121 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FAM136A http://www.ncbi.nlm.nih.gov/gene/84908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001122 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FAM160B1 http://www.ncbi.nlm.nih.gov/gene/57700 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001123 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FAM177A1 http://www.ncbi.nlm.nih.gov/gene/283635 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001124 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FAM178A http://www.ncbi.nlm.nih.gov/gene/55719 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001125 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FAM46C http://www.ncbi.nlm.nih.gov/gene/54855 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001126 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FAM63B http://www.ncbi.nlm.nih.gov/gene/54629 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001127 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FAM73A http://www.ncbi.nlm.nih.gov/gene/374986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001128 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FAM82B http://www.ncbi.nlm.nih.gov/gene/51115 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001129 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FANCF http://www.ncbi.nlm.nih.gov/gene/2188 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001130 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FBXO11 http://www.ncbi.nlm.nih.gov/gene/80204 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001131 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FBXO28 http://www.ncbi.nlm.nih.gov/gene/23219 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001132 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FCHO2 http://www.ncbi.nlm.nih.gov/gene/115548 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001133 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FDXACB1 http://www.ncbi.nlm.nih.gov/gene/91893 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001134 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FGFR1OP http://www.ncbi.nlm.nih.gov/gene/11116 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001135 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FKBP7 http://www.ncbi.nlm.nih.gov/gene/51661 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001136 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FNBP4 http://www.ncbi.nlm.nih.gov/gene/23360 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001137 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FNIP1 http://www.ncbi.nlm.nih.gov/gene/96459 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001138 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FNTB http://www.ncbi.nlm.nih.gov/gene/2342 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001139 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FOXJ3 http://www.ncbi.nlm.nih.gov/gene/22887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001140 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FOXK2 http://www.ncbi.nlm.nih.gov/gene/3607 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001141 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FSTL5 http://www.ncbi.nlm.nih.gov/gene/56884 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001142 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FUSIP1 http://www.ncbi.nlm.nih.gov/gene/10772 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001143 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FZD1 http://www.ncbi.nlm.nih.gov/gene/8321 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001144 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA FZD3 http://www.ncbi.nlm.nih.gov/gene/7976 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001145 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA G3BP2 http://www.ncbi.nlm.nih.gov/gene/9908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001146 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA GAB1 http://www.ncbi.nlm.nih.gov/gene/2549 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001147 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA GADD45A http://www.ncbi.nlm.nih.gov/gene/1647 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001148 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA GALNT7 http://www.ncbi.nlm.nih.gov/gene/51809 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001149 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA GATAD1 http://www.ncbi.nlm.nih.gov/gene/57798 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001150 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA GATAD2B http://www.ncbi.nlm.nih.gov/gene/57459 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001151 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA GBAS http://www.ncbi.nlm.nih.gov/gene/2631 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001152 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA GCNT2 http://www.ncbi.nlm.nih.gov/gene/2651 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001153 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA GLO1 http://www.ncbi.nlm.nih.gov/gene/2739 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001154 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA GLUL http://www.ncbi.nlm.nih.gov/gene/2752 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001155 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA GMFB http://www.ncbi.nlm.nih.gov/gene/2764 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001156 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA GNB1 http://www.ncbi.nlm.nih.gov/gene/2782 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001157 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA GOLT1B http://www.ncbi.nlm.nih.gov/gene/51026 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001158 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA GOSR1 http://www.ncbi.nlm.nih.gov/gene/9527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001159 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA GPD2 http://www.ncbi.nlm.nih.gov/gene/2820 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001160 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA GRLF1 http://www.ncbi.nlm.nih.gov/gene/2909 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001161 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA GSK3B http://www.ncbi.nlm.nih.gov/gene/2932 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001162 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HAUS1 http://www.ncbi.nlm.nih.gov/gene/115106 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001163 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HAUS2 http://www.ncbi.nlm.nih.gov/gene/55142 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001164 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HAUS3 http://www.ncbi.nlm.nih.gov/gene/79441 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001165 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HAUS5 http://www.ncbi.nlm.nih.gov/gene/23354 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001166 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HCFC2 http://www.ncbi.nlm.nih.gov/gene/29915 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001167 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HDHD3 http://www.ncbi.nlm.nih.gov/gene/81932 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001168 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HEATR2 http://www.ncbi.nlm.nih.gov/gene/54919 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001169 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HECTD1 http://www.ncbi.nlm.nih.gov/gene/25831 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001170 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HELQ http://www.ncbi.nlm.nih.gov/gene/113510 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001171 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HERPUD1 http://www.ncbi.nlm.nih.gov/gene/9709 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001172 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HIPK1 http://www.ncbi.nlm.nih.gov/gene/204851 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001173 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HIST1H2AJ http://www.ncbi.nlm.nih.gov/gene/8331 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001174 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HIST1H4C http://www.ncbi.nlm.nih.gov/gene/8367 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001175 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HIVEP2 http://www.ncbi.nlm.nih.gov/gene/3097 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001176 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HMGB1 http://www.ncbi.nlm.nih.gov/gene/3146 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001177 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HMGXB4 http://www.ncbi.nlm.nih.gov/gene/10042 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001178 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HN1 http://www.ncbi.nlm.nih.gov/gene/51155 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001179 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HN1L http://www.ncbi.nlm.nih.gov/gene/90861 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001180 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HNRNPUL2 http://www.ncbi.nlm.nih.gov/gene/221092 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001181 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HOOK1 http://www.ncbi.nlm.nih.gov/gene/51361 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001182 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HSBP1 http://www.ncbi.nlm.nih.gov/gene/3281 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001183 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA HSD17B12 http://www.ncbi.nlm.nih.gov/gene/51144 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001184 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ICK http://www.ncbi.nlm.nih.gov/gene/22858 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001185 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA IKZF1 http://www.ncbi.nlm.nih.gov/gene/10320 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001186 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA IL6ST http://www.ncbi.nlm.nih.gov/gene/3572 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001187 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA IMPA1 http://www.ncbi.nlm.nih.gov/gene/3612 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001188 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA INO80D http://www.ncbi.nlm.nih.gov/gene/54891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001189 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA INSIG1 http://www.ncbi.nlm.nih.gov/gene/3638 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001190 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA INTS2 http://www.ncbi.nlm.nih.gov/gene/57508 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001191 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA IPO7 http://www.ncbi.nlm.nih.gov/gene/10527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001192 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA IPO8 http://www.ncbi.nlm.nih.gov/gene/10526 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001193 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA IQSEC1 http://www.ncbi.nlm.nih.gov/gene/9922 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001194 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA IRAK1BP1 http://www.ncbi.nlm.nih.gov/gene/134728 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001195 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ITPKB http://www.ncbi.nlm.nih.gov/gene/3707 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001196 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA IVD http://www.ncbi.nlm.nih.gov/gene/3712 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001197 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA JMY http://www.ncbi.nlm.nih.gov/gene/133746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001198 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA KAT2B http://www.ncbi.nlm.nih.gov/gene/8850 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001199 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA KDM5B http://www.ncbi.nlm.nih.gov/gene/10765 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001200 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA KIAA0317 http://www.ncbi.nlm.nih.gov/gene/9870 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001201 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA KIAA0831 http://www.ncbi.nlm.nih.gov/gene/22863 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001202 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA KIAA0947 http://www.ncbi.nlm.nih.gov/gene/23379 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001203 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA KIAA1211 http://www.ncbi.nlm.nih.gov/gene/57482 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001204 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA KIAA1219 http://www.ncbi.nlm.nih.gov/gene/57148 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001205 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA KIAA1430 http://www.ncbi.nlm.nih.gov/gene/57587 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001206 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA KIAA1432 http://www.ncbi.nlm.nih.gov/gene/57589 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001207 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA KIAA2018 http://www.ncbi.nlm.nih.gov/gene/205717 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001208 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA KIF23 http://www.ncbi.nlm.nih.gov/gene/9493 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001209 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA KLHL14 http://www.ncbi.nlm.nih.gov/gene/57565 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001210 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA KPNA5 http://www.ncbi.nlm.nih.gov/gene/3841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001211 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA KRCC1 http://www.ncbi.nlm.nih.gov/gene/51315 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001212 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA LAMP2 http://www.ncbi.nlm.nih.gov/gene/3920 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001213 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA LANCL1 http://www.ncbi.nlm.nih.gov/gene/10314 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001214 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA LASP1 http://www.ncbi.nlm.nih.gov/gene/3927 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001215 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA LBR http://www.ncbi.nlm.nih.gov/gene/3930 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001216 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA LCOR http://www.ncbi.nlm.nih.gov/gene/84458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001217 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA LIN28B http://www.ncbi.nlm.nih.gov/gene/389421 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001218 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA LIN54 http://www.ncbi.nlm.nih.gov/gene/132660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001219 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA LIN9 http://www.ncbi.nlm.nih.gov/gene/286826 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001220 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA LIPA http://www.ncbi.nlm.nih.gov/gene/3988 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001221 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA LMAN1 http://www.ncbi.nlm.nih.gov/gene/3998 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001222 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA LRRC58 http://www.ncbi.nlm.nih.gov/gene/116064 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001223 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA LSM1 http://www.ncbi.nlm.nih.gov/gene/27257 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001224 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA LYRM5 http://www.ncbi.nlm.nih.gov/gene/144363 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001225 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA LYST http://www.ncbi.nlm.nih.gov/gene/1130 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001226 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA LZIC http://www.ncbi.nlm.nih.gov/gene/84328 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001227 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MAK16 http://www.ncbi.nlm.nih.gov/gene/84549 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001228 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MAL2 http://www.ncbi.nlm.nih.gov/gene/114569 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001229 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MAP3K2 http://www.ncbi.nlm.nih.gov/gene/10746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001230 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MAPK8 http://www.ncbi.nlm.nih.gov/gene/5599 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001231 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MBNL1 http://www.ncbi.nlm.nih.gov/gene/4154 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001232 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MBNL2 http://www.ncbi.nlm.nih.gov/gene/10150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001233 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MBNL3 http://www.ncbi.nlm.nih.gov/gene/55796 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001234 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MBTPS2 http://www.ncbi.nlm.nih.gov/gene/51360 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001235 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MDM2 http://www.ncbi.nlm.nih.gov/gene/4193 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001236 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MDN1 http://www.ncbi.nlm.nih.gov/gene/23195 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001237 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MECP2 http://www.ncbi.nlm.nih.gov/gene/4204 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001238 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MED14 http://www.ncbi.nlm.nih.gov/gene/9282 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001239 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA METTL10 http://www.ncbi.nlm.nih.gov/gene/399818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001240 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA METTL5 http://www.ncbi.nlm.nih.gov/gene/29081 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001241 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MFSD8 http://www.ncbi.nlm.nih.gov/gene/256471 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001242 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MKL2 http://www.ncbi.nlm.nih.gov/gene/57496 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001243 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MKRN1 http://www.ncbi.nlm.nih.gov/gene/23608 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001244 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MLL http://www.ncbi.nlm.nih.gov/gene/4297 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001245 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MLL2 http://www.ncbi.nlm.nih.gov/gene/8085 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001246 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MOBKL1A http://www.ncbi.nlm.nih.gov/gene/92597 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001247 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MON1B http://www.ncbi.nlm.nih.gov/gene/22879 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001248 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MPP5 http://www.ncbi.nlm.nih.gov/gene/64398 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001249 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MRFAP1 http://www.ncbi.nlm.nih.gov/gene/93621 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001250 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MRP63 http://www.ncbi.nlm.nih.gov/gene/78988 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001251 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MRPL50 http://www.ncbi.nlm.nih.gov/gene/54534 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001252 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MTA1 http://www.ncbi.nlm.nih.gov/gene/9112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001253 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MTBP http://www.ncbi.nlm.nih.gov/gene/27085 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001254 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MTHFR http://www.ncbi.nlm.nih.gov/gene/4524 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001255 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MTMR12 http://www.ncbi.nlm.nih.gov/gene/54545 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001256 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MTRR http://www.ncbi.nlm.nih.gov/gene/4552 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001257 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MTUS1 http://www.ncbi.nlm.nih.gov/gene/57509 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001258 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MXD1 http://www.ncbi.nlm.nih.gov/gene/4084 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001259 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MXD4 http://www.ncbi.nlm.nih.gov/gene/10608 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001260 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MYO5A http://www.ncbi.nlm.nih.gov/gene/4644 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001261 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA MYO9A http://www.ncbi.nlm.nih.gov/gene/4649 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001262 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NAPB http://www.ncbi.nlm.nih.gov/gene/63908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001263 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NAPG http://www.ncbi.nlm.nih.gov/gene/8774 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001264 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NCK1 http://www.ncbi.nlm.nih.gov/gene/4690 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001265 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NDNL2 http://www.ncbi.nlm.nih.gov/gene/56160 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001266 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NDRG3 http://www.ncbi.nlm.nih.gov/gene/57446 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001267 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NDUFA8 http://www.ncbi.nlm.nih.gov/gene/4702 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001268 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NDUFB5 http://www.ncbi.nlm.nih.gov/gene/4711 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001269 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NEK7 http://www.ncbi.nlm.nih.gov/gene/140609 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001270 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NENF http://www.ncbi.nlm.nih.gov/gene/29937 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001271 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NEO1 http://www.ncbi.nlm.nih.gov/gene/4756 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001272 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NFIA http://www.ncbi.nlm.nih.gov/gene/4774 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001273 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001274 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NGRN http://www.ncbi.nlm.nih.gov/gene/51335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001275 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NHLRC2 http://www.ncbi.nlm.nih.gov/gene/374354 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001276 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NIPA2 http://www.ncbi.nlm.nih.gov/gene/81614 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001277 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NLGN1 http://www.ncbi.nlm.nih.gov/gene/22871 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001278 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NOLC1 http://www.ncbi.nlm.nih.gov/gene/9221 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001279 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NONO http://www.ncbi.nlm.nih.gov/gene/4841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001280 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NOP56 http://www.ncbi.nlm.nih.gov/gene/10528 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001281 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NPHP1 http://www.ncbi.nlm.nih.gov/gene/4867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001282 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NR3C1 http://www.ncbi.nlm.nih.gov/gene/2908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001283 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NRBF2 http://www.ncbi.nlm.nih.gov/gene/29982 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001284 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NT5C2 http://www.ncbi.nlm.nih.gov/gene/22978 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001285 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NUDT19 http://www.ncbi.nlm.nih.gov/gene/390916 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001286 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NUFIP2 http://www.ncbi.nlm.nih.gov/gene/57532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001287 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA NUP54 http://www.ncbi.nlm.nih.gov/gene/53371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001288 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA OGT http://www.ncbi.nlm.nih.gov/gene/8473 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001289 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ORC5L http://www.ncbi.nlm.nih.gov/gene/5001 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001290 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA OSBP http://www.ncbi.nlm.nih.gov/gene/5007 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001291 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA OTUD7B http://www.ncbi.nlm.nih.gov/gene/56957 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001292 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA OXSM http://www.ncbi.nlm.nih.gov/gene/54995 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001293 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PABPCP5 http://www.ncbi.nlm.nih.gov/gene/341315 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001294 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PALM2-AKAP2 http://www.ncbi.nlm.nih.gov/gene/114299 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001295 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PANK3 http://www.ncbi.nlm.nih.gov/gene/79646 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001296 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PAPOLA http://www.ncbi.nlm.nih.gov/gene/10914 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001297 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PARD6B http://www.ncbi.nlm.nih.gov/gene/84612 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001298 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PARP8 http://www.ncbi.nlm.nih.gov/gene/79668 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001299 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PBX2 http://www.ncbi.nlm.nih.gov/gene/5089 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001300 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PCDH9 http://www.ncbi.nlm.nih.gov/gene/5101 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001301 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PCGF3 http://www.ncbi.nlm.nih.gov/gene/10336 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001302 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PDCD10 http://www.ncbi.nlm.nih.gov/gene/11235 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001303 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PDCL http://www.ncbi.nlm.nih.gov/gene/5082 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001304 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PDE7A http://www.ncbi.nlm.nih.gov/gene/5150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001305 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PDIA6 http://www.ncbi.nlm.nih.gov/gene/10130 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001306 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PDIK1L http://www.ncbi.nlm.nih.gov/gene/149420 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001307 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PELI1 http://www.ncbi.nlm.nih.gov/gene/57162 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001308 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PELO http://www.ncbi.nlm.nih.gov/gene/53918 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001309 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PHC3 http://www.ncbi.nlm.nih.gov/gene/80012 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001310 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PHF20L1 http://www.ncbi.nlm.nih.gov/gene/51105 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001311 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PIBF1 http://www.ncbi.nlm.nih.gov/gene/10464 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001312 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PIGN http://www.ncbi.nlm.nih.gov/gene/23556 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001313 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PIK3C3 http://www.ncbi.nlm.nih.gov/gene/5289 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001314 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PIK3CB http://www.ncbi.nlm.nih.gov/gene/5291 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001315 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PIP5K1C http://www.ncbi.nlm.nih.gov/gene/23396 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001316 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PITPNB http://www.ncbi.nlm.nih.gov/gene/23760 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001317 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PKN2 http://www.ncbi.nlm.nih.gov/gene/5586 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001318 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PLDN http://www.ncbi.nlm.nih.gov/gene/26258 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001319 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PLS1 http://www.ncbi.nlm.nih.gov/gene/5357 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001320 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA POU2F1 http://www.ncbi.nlm.nih.gov/gene/5451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001321 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA POU2F2 http://www.ncbi.nlm.nih.gov/gene/5452 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001322 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PPARGC1A http://www.ncbi.nlm.nih.gov/gene/10891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001323 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PPM1A http://www.ncbi.nlm.nih.gov/gene/5494 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001324 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PPM1B http://www.ncbi.nlm.nih.gov/gene/5495 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001325 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PPP1R12A http://www.ncbi.nlm.nih.gov/gene/4659 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001326 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PPP1R15B http://www.ncbi.nlm.nih.gov/gene/84919 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001327 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PPP2R5A http://www.ncbi.nlm.nih.gov/gene/5525 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001328 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PPP3CA http://www.ncbi.nlm.nih.gov/gene/5530 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001329 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PPP4R2 http://www.ncbi.nlm.nih.gov/gene/151987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001330 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PPPDE2 http://www.ncbi.nlm.nih.gov/gene/27351 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001331 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PRDM1 http://www.ncbi.nlm.nih.gov/gene/639 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001332 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PRDM2 http://www.ncbi.nlm.nih.gov/gene/7799 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001333 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PRDM8 http://www.ncbi.nlm.nih.gov/gene/56978 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001334 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PRKACB http://www.ncbi.nlm.nih.gov/gene/5567 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001335 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PRKAR1A http://www.ncbi.nlm.nih.gov/gene/5573 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001336 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PRMT3 http://www.ncbi.nlm.nih.gov/gene/10196 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001337 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PROK2 http://www.ncbi.nlm.nih.gov/gene/60675 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001338 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PRPF40A http://www.ncbi.nlm.nih.gov/gene/55660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001339 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PSMC2 http://www.ncbi.nlm.nih.gov/gene/5701 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001340 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PTAR1 http://www.ncbi.nlm.nih.gov/gene/375743 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001341 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PTN http://www.ncbi.nlm.nih.gov/gene/5764 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001342 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PTPLB http://www.ncbi.nlm.nih.gov/gene/201562 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001343 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PTPN1 http://www.ncbi.nlm.nih.gov/gene/5770 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001344 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PTPN12 http://www.ncbi.nlm.nih.gov/gene/5782 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001345 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PURB http://www.ncbi.nlm.nih.gov/gene/5814 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001346 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PUS7 http://www.ncbi.nlm.nih.gov/gene/54517 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001347 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PVRL3 http://www.ncbi.nlm.nih.gov/gene/25945 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001348 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA PWWP2A http://www.ncbi.nlm.nih.gov/gene/114825 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001349 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA QKI http://www.ncbi.nlm.nih.gov/gene/9444 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001350 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA QSOX2 http://www.ncbi.nlm.nih.gov/gene/169714 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001351 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA R3HDM1 http://www.ncbi.nlm.nih.gov/gene/23518 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001352 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RAB12 http://www.ncbi.nlm.nih.gov/gene/201475 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001353 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RAB14 http://www.ncbi.nlm.nih.gov/gene/51552 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001354 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RAB1A http://www.ncbi.nlm.nih.gov/gene/5861 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001355 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RAB21 http://www.ncbi.nlm.nih.gov/gene/23011 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001356 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RAB35 http://www.ncbi.nlm.nih.gov/gene/11021 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001357 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RAB5B http://www.ncbi.nlm.nih.gov/gene/5869 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001358 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RAB8B http://www.ncbi.nlm.nih.gov/gene/51762 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001359 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RABEP1 http://www.ncbi.nlm.nih.gov/gene/9135 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001360 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RABL3 http://www.ncbi.nlm.nih.gov/gene/285282 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001361 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RAD18 http://www.ncbi.nlm.nih.gov/gene/56852 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001362 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RAD21 http://www.ncbi.nlm.nih.gov/gene/5885 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001363 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RAD51C http://www.ncbi.nlm.nih.gov/gene/5889 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001364 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RAD52 http://www.ncbi.nlm.nih.gov/gene/5893 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001365 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RAF1 http://www.ncbi.nlm.nih.gov/gene/5894 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001366 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RALGPS1 http://www.ncbi.nlm.nih.gov/gene/9649 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001367 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RBL2 http://www.ncbi.nlm.nih.gov/gene/5934 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001368 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RBM25 http://www.ncbi.nlm.nih.gov/gene/58517 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001369 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RBM33 http://www.ncbi.nlm.nih.gov/gene/155435 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001370 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RBM47 http://www.ncbi.nlm.nih.gov/gene/54502 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001371 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RBMXL1 http://www.ncbi.nlm.nih.gov/gene/494115 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001372 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RC3H1 http://www.ncbi.nlm.nih.gov/gene/149041 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001373 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RCN2 http://www.ncbi.nlm.nih.gov/gene/5955 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001374 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RCOR1 http://www.ncbi.nlm.nih.gov/gene/23186 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001375 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RCOR3 http://www.ncbi.nlm.nih.gov/gene/55758 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001376 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RFK http://www.ncbi.nlm.nih.gov/gene/55312 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001377 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RFXAP http://www.ncbi.nlm.nih.gov/gene/5994 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001378 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RGL1 http://www.ncbi.nlm.nih.gov/gene/23179 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001379 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RHOH http://www.ncbi.nlm.nih.gov/gene/399 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001380 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RHOU http://www.ncbi.nlm.nih.gov/gene/58480 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001381 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RIF1 http://www.ncbi.nlm.nih.gov/gene/55183 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001382 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RIMBP2 http://www.ncbi.nlm.nih.gov/gene/23504 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001383 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RNASEL http://www.ncbi.nlm.nih.gov/gene/6041 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001384 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RNF20 http://www.ncbi.nlm.nih.gov/gene/56254 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001385 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RNF6 http://www.ncbi.nlm.nih.gov/gene/6049 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001386 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RORA http://www.ncbi.nlm.nih.gov/gene/6095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001387 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RPL13 http://www.ncbi.nlm.nih.gov/gene/388344 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001388 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RPL35A http://www.ncbi.nlm.nih.gov/gene/6165 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001389 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RPN1 http://www.ncbi.nlm.nih.gov/gene/6184 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001390 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RPRD1A http://www.ncbi.nlm.nih.gov/gene/55197 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001391 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RPUSD4 http://www.ncbi.nlm.nih.gov/gene/84881 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001392 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RREB1 http://www.ncbi.nlm.nih.gov/gene/6239 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001393 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RRM2 http://www.ncbi.nlm.nih.gov/gene/6241 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001394 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RRN3 http://www.ncbi.nlm.nih.gov/gene/54700 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001395 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RSF1 http://www.ncbi.nlm.nih.gov/gene/51773 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001396 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA RUNX2 http://www.ncbi.nlm.nih.gov/gene/860 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001397 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SACM1L http://www.ncbi.nlm.nih.gov/gene/22908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001398 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SAMSN1 http://www.ncbi.nlm.nih.gov/gene/64092 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001399 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SAP18 http://www.ncbi.nlm.nih.gov/gene/10284 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001400 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SAR1B http://www.ncbi.nlm.nih.gov/gene/51128 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001401 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SBF2 http://www.ncbi.nlm.nih.gov/gene/81846 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001402 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SCAMP1 http://www.ncbi.nlm.nih.gov/gene/9522 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001403 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SDAD1 http://www.ncbi.nlm.nih.gov/gene/55153 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001404 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SDF2 http://www.ncbi.nlm.nih.gov/gene/6388 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001405 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SEMA3A http://www.ncbi.nlm.nih.gov/gene/10371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001406 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SETD7 http://www.ncbi.nlm.nih.gov/gene/80854 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001407 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SETD8 http://www.ncbi.nlm.nih.gov/gene/387893 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001408 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SFRS15 http://www.ncbi.nlm.nih.gov/gene/57466 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001409 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SFT2D3 http://www.ncbi.nlm.nih.gov/gene/84826 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001410 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SH3BGRL2 http://www.ncbi.nlm.nih.gov/gene/83699 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001411 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SIK2 http://www.ncbi.nlm.nih.gov/gene/23235 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001412 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SIKE1 http://www.ncbi.nlm.nih.gov/gene/80143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001413 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SIRT1 http://www.ncbi.nlm.nih.gov/gene/23411 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001414 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SLAMF7 http://www.ncbi.nlm.nih.gov/gene/57823 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001415 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SLC16A6 http://www.ncbi.nlm.nih.gov/gene/9120 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001416 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SLC20A1 http://www.ncbi.nlm.nih.gov/gene/6574 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001417 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SLC25A36 http://www.ncbi.nlm.nih.gov/gene/55186 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001418 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SLC35A5 http://www.ncbi.nlm.nih.gov/gene/55032 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001419 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SLC35F2 http://www.ncbi.nlm.nih.gov/gene/54733 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001420 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SLC39A10 http://www.ncbi.nlm.nih.gov/gene/57181 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001421 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SLC3A2 http://www.ncbi.nlm.nih.gov/gene/6520 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001422 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SMEK2 http://www.ncbi.nlm.nih.gov/gene/57223 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001423 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SMG1 http://www.ncbi.nlm.nih.gov/gene/23049 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001424 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SMURF1 http://www.ncbi.nlm.nih.gov/gene/57154 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001425 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SMURF2 http://www.ncbi.nlm.nih.gov/gene/64750 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001426 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SMYD5 http://www.ncbi.nlm.nih.gov/gene/10322 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001427 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SNAPC5 http://www.ncbi.nlm.nih.gov/gene/10302 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001428 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SNRK http://www.ncbi.nlm.nih.gov/gene/54861 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001429 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SNTB2 http://www.ncbi.nlm.nih.gov/gene/6645 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001430 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SNX29 http://www.ncbi.nlm.nih.gov/gene/92017 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001431 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SNX3 http://www.ncbi.nlm.nih.gov/gene/8724 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001432 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SNX5 http://www.ncbi.nlm.nih.gov/gene/27131 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001433 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SOS1 http://www.ncbi.nlm.nih.gov/gene/6654 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001434 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SP1 http://www.ncbi.nlm.nih.gov/gene/6667 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001435 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SP2 http://www.ncbi.nlm.nih.gov/gene/6668 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001436 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SP3 http://www.ncbi.nlm.nih.gov/gene/6670 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001437 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SPAG9 http://www.ncbi.nlm.nih.gov/gene/9043 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001438 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SPAST http://www.ncbi.nlm.nih.gov/gene/6683 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001439 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SPATS2L http://www.ncbi.nlm.nih.gov/gene/26010 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001440 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SPCS3 http://www.ncbi.nlm.nih.gov/gene/60559 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001441 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SPG20 http://www.ncbi.nlm.nih.gov/gene/23111 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001442 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SPG21 http://www.ncbi.nlm.nih.gov/gene/51324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001443 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SPSB1 http://www.ncbi.nlm.nih.gov/gene/80176 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001444 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA STAG2 http://www.ncbi.nlm.nih.gov/gene/10735 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001445 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA STAMBP http://www.ncbi.nlm.nih.gov/gene/10617 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001446 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA STAT6 http://www.ncbi.nlm.nih.gov/gene/6778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001447 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA STIM2 http://www.ncbi.nlm.nih.gov/gene/57620 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001448 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA STK38L http://www.ncbi.nlm.nih.gov/gene/23012 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001449 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA STK4 http://www.ncbi.nlm.nih.gov/gene/6789 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001450 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA STRN http://www.ncbi.nlm.nih.gov/gene/6801 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001451 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA STYX http://www.ncbi.nlm.nih.gov/gene/6815 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001452 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SYNJ2BP http://www.ncbi.nlm.nih.gov/gene/55333 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001453 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA SYT4 http://www.ncbi.nlm.nih.gov/gene/6860 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001454 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TAF3 http://www.ncbi.nlm.nih.gov/gene/83860 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001455 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TAF9B http://www.ncbi.nlm.nih.gov/gene/51616 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001456 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TAOK1 http://www.ncbi.nlm.nih.gov/gene/57551 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001457 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TBC1D14 http://www.ncbi.nlm.nih.gov/gene/57533 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001458 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TBL1XR1 http://www.ncbi.nlm.nih.gov/gene/79718 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001459 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TCERG1 http://www.ncbi.nlm.nih.gov/gene/10915 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001460 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TCF3 http://www.ncbi.nlm.nih.gov/gene/6929 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001461 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TCF4 http://www.ncbi.nlm.nih.gov/gene/6925 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001462 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TCF7L2 http://www.ncbi.nlm.nih.gov/gene/6934 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001463 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TET1 http://www.ncbi.nlm.nih.gov/gene/80312 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001464 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TET2 http://www.ncbi.nlm.nih.gov/gene/54790 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001465 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TFRC http://www.ncbi.nlm.nih.gov/gene/7037 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001466 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TGFBR3 http://www.ncbi.nlm.nih.gov/gene/7049 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001467 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TLK1 http://www.ncbi.nlm.nih.gov/gene/9874 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001468 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TMBIM4 http://www.ncbi.nlm.nih.gov/gene/51643 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001469 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TMCC1 http://www.ncbi.nlm.nih.gov/gene/23023 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001470 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TMCO1 http://www.ncbi.nlm.nih.gov/gene/54499 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001471 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TMEM106B http://www.ncbi.nlm.nih.gov/gene/54664 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001472 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TMEM126A http://www.ncbi.nlm.nih.gov/gene/84233 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001473 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TMEM192 http://www.ncbi.nlm.nih.gov/gene/201931 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001474 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TMEM30A http://www.ncbi.nlm.nih.gov/gene/55754 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001475 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TMEM64 http://www.ncbi.nlm.nih.gov/gene/169200 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001476 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TMPO http://www.ncbi.nlm.nih.gov/gene/7112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001477 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TNPO1 http://www.ncbi.nlm.nih.gov/gene/3842 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001478 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TNRC6B http://www.ncbi.nlm.nih.gov/gene/23112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001479 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TP53INP1 http://www.ncbi.nlm.nih.gov/gene/94241 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001480 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TPD52 http://www.ncbi.nlm.nih.gov/gene/7163 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001481 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TPRKB http://www.ncbi.nlm.nih.gov/gene/51002 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001482 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TRA2B http://www.ncbi.nlm.nih.gov/gene/6434 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001483 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TRIB1 http://www.ncbi.nlm.nih.gov/gene/10221 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001484 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TRIB3 http://www.ncbi.nlm.nih.gov/gene/57761 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001485 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TRIM22 http://www.ncbi.nlm.nih.gov/gene/10346 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001486 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TRIM26 http://www.ncbi.nlm.nih.gov/gene/7726 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001487 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TRIO http://www.ncbi.nlm.nih.gov/gene/7204 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001488 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TROVE2 http://www.ncbi.nlm.nih.gov/gene/6738 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001489 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TSC22D2 http://www.ncbi.nlm.nih.gov/gene/9819 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001490 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TSN http://www.ncbi.nlm.nih.gov/gene/7247 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001491 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TSPYL1 http://www.ncbi.nlm.nih.gov/gene/7259 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001492 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TTC27 http://www.ncbi.nlm.nih.gov/gene/55622 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001493 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TUBGCP3 http://www.ncbi.nlm.nih.gov/gene/10426 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001494 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA TWSG1 http://www.ncbi.nlm.nih.gov/gene/57045 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001495 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA UBE2D1 http://www.ncbi.nlm.nih.gov/gene/7321 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001496 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA UBE2H http://www.ncbi.nlm.nih.gov/gene/7328 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001497 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA UBE3A http://www.ncbi.nlm.nih.gov/gene/7337 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001498 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA UBE3C http://www.ncbi.nlm.nih.gov/gene/9690 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001499 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA UBFD1 http://www.ncbi.nlm.nih.gov/gene/56061 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001500 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA UBN2 http://www.ncbi.nlm.nih.gov/gene/254048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001501 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA UBQLN1 http://www.ncbi.nlm.nih.gov/gene/29979 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001502 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA UCK2 http://www.ncbi.nlm.nih.gov/gene/7371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001503 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA UGCG http://www.ncbi.nlm.nih.gov/gene/7357 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001504 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA UHMK1 http://www.ncbi.nlm.nih.gov/gene/127933 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001505 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA UHRF1BP1L http://www.ncbi.nlm.nih.gov/gene/23074 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001506 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA USP25 http://www.ncbi.nlm.nih.gov/gene/29761 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001507 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA USP38 http://www.ncbi.nlm.nih.gov/gene/84640 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001508 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA USP42 http://www.ncbi.nlm.nih.gov/gene/84132 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001509 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA USP6NL http://www.ncbi.nlm.nih.gov/gene/9712 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001510 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA VANGL1 http://www.ncbi.nlm.nih.gov/gene/81839 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001511 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA VGLL4 http://www.ncbi.nlm.nih.gov/gene/9686 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001512 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA VPS45 http://www.ncbi.nlm.nih.gov/gene/11311 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001513 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA VTA1 http://www.ncbi.nlm.nih.gov/gene/51534 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001514 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA WAPAL http://www.ncbi.nlm.nih.gov/gene/23063 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001515 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA WASL http://www.ncbi.nlm.nih.gov/gene/8976 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001516 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA WDR26 http://www.ncbi.nlm.nih.gov/gene/80232 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001517 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA WDR27 http://www.ncbi.nlm.nih.gov/gene/253769 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001518 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA WDR55 http://www.ncbi.nlm.nih.gov/gene/54853 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001519 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA WDR82 http://www.ncbi.nlm.nih.gov/gene/80335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001520 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA WDR92 http://www.ncbi.nlm.nih.gov/gene/116143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001521 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA WSB2 http://www.ncbi.nlm.nih.gov/gene/55884 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001522 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA WWC1 http://www.ncbi.nlm.nih.gov/gene/23286 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001523 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA WWTR1 http://www.ncbi.nlm.nih.gov/gene/25937 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001524 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA XPO1 http://www.ncbi.nlm.nih.gov/gene/7514 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001525 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA XPO4 http://www.ncbi.nlm.nih.gov/gene/64328 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001526 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA YKT6 http://www.ncbi.nlm.nih.gov/gene/10652 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001527 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA YME1L1 http://www.ncbi.nlm.nih.gov/gene/10730 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001528 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA YPEL5 http://www.ncbi.nlm.nih.gov/gene/51646 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001529 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA YTHDF1 http://www.ncbi.nlm.nih.gov/gene/54915 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001530 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA YWHAB http://www.ncbi.nlm.nih.gov/gene/7529 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001531 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA YWHAZ http://www.ncbi.nlm.nih.gov/gene/7534 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001532 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZAK http://www.ncbi.nlm.nih.gov/gene/51776 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001533 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZBTB20 http://www.ncbi.nlm.nih.gov/gene/26137 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001534 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZBTB38 http://www.ncbi.nlm.nih.gov/gene/253461 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001535 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZC3HAV1 http://www.ncbi.nlm.nih.gov/gene/56829 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001536 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZCRB1 http://www.ncbi.nlm.nih.gov/gene/85437 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001537 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZDHHC17 http://www.ncbi.nlm.nih.gov/gene/23390 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001538 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZFAND5 http://www.ncbi.nlm.nih.gov/gene/732229 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001539 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZFP36L1 http://www.ncbi.nlm.nih.gov/gene/677 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001540 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZFP36L2 http://www.ncbi.nlm.nih.gov/gene/678 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001541 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZFP91 http://www.ncbi.nlm.nih.gov/gene/386607 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001542 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZFX http://www.ncbi.nlm.nih.gov/gene/7543 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001543 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZKSCAN1 http://www.ncbi.nlm.nih.gov/gene/7586 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001544 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZMYND11 http://www.ncbi.nlm.nih.gov/gene/10771 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001545 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZNF100 http://www.ncbi.nlm.nih.gov/gene/163227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001546 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZNF138 http://www.ncbi.nlm.nih.gov/gene/7697 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001547 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZNF148 http://www.ncbi.nlm.nih.gov/gene/7707 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001548 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZNF238 http://www.ncbi.nlm.nih.gov/gene/10472 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001549 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZNF326 http://www.ncbi.nlm.nih.gov/gene/284695 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001550 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZNF37A http://www.ncbi.nlm.nih.gov/gene/7587 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001551 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZNF410 http://www.ncbi.nlm.nih.gov/gene/57862 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001552 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZNF493 http://www.ncbi.nlm.nih.gov/gene/284443 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001553 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZNF507 http://www.ncbi.nlm.nih.gov/gene/22847 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001554 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZNF518A http://www.ncbi.nlm.nih.gov/gene/9849 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001555 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZNF621 http://www.ncbi.nlm.nih.gov/gene/285268 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001556 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZNF652 http://www.ncbi.nlm.nih.gov/gene/22834 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001557 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZNF681 http://www.ncbi.nlm.nih.gov/gene/148213 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001558 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZNF684 http://www.ncbi.nlm.nih.gov/gene/127396 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001559 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZNF708 http://www.ncbi.nlm.nih.gov/gene/7562 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001560 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZRANB2 http://www.ncbi.nlm.nih.gov/gene/9406 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001561 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-3p(ebv-mir-bart19-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003718 BC-1 - Host mRNA ZSWIM6 http://www.ncbi.nlm.nih.gov/gene/57688 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001562 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA API5L1 http://www.ncbi.nlm.nih.gov/gene/8539 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001563 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA APOL4 http://www.ncbi.nlm.nih.gov/gene/80832 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001564 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA ARL6IP1 http://www.ncbi.nlm.nih.gov/gene/23204 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001565 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA ARMC8 http://www.ncbi.nlm.nih.gov/gene/25852 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001566 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA C11orf46 http://www.ncbi.nlm.nih.gov/gene/120534 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001567 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA C5orf30 http://www.ncbi.nlm.nih.gov/gene/90355 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001568 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA C5orf32 http://www.ncbi.nlm.nih.gov/gene/84418 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001569 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA CDC23 http://www.ncbi.nlm.nih.gov/gene/8697 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001570 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA CDC42 http://www.ncbi.nlm.nih.gov/gene/998 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001571 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA CDV3 http://www.ncbi.nlm.nih.gov/gene/55573 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001572 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA COPS7A http://www.ncbi.nlm.nih.gov/gene/50813 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001573 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA CUL5 http://www.ncbi.nlm.nih.gov/gene/8065 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001574 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA CYB5D1 http://www.ncbi.nlm.nih.gov/gene/124637 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001575 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA DDI2 http://www.ncbi.nlm.nih.gov/gene/84301 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001576 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA DYRK2 http://www.ncbi.nlm.nih.gov/gene/8445 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001577 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA EEF1A1 http://www.ncbi.nlm.nih.gov/gene/441032 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001578 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA ELK4 http://www.ncbi.nlm.nih.gov/gene/2005 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001579 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA FAM91A1 http://www.ncbi.nlm.nih.gov/gene/157769 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001580 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA GRIA2 http://www.ncbi.nlm.nih.gov/gene/2891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001581 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA HSPA1B http://www.ncbi.nlm.nih.gov/gene/3303 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001582 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA ILDR1 http://www.ncbi.nlm.nih.gov/gene/286676 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001583 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA INSR http://www.ncbi.nlm.nih.gov/gene/3643 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001584 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA IRF4 http://www.ncbi.nlm.nih.gov/gene/3662 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001585 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA LCOR http://www.ncbi.nlm.nih.gov/gene/84458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001586 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA LIN7C http://www.ncbi.nlm.nih.gov/gene/55327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001587 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA LRIG3 http://www.ncbi.nlm.nih.gov/gene/121227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001588 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA MTF2 http://www.ncbi.nlm.nih.gov/gene/22823 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001589 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA NOLC1 http://www.ncbi.nlm.nih.gov/gene/9221 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001590 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA PERP http://www.ncbi.nlm.nih.gov/gene/64065 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001591 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA PI4K2B http://www.ncbi.nlm.nih.gov/gene/55300 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001592 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA PSAP http://www.ncbi.nlm.nih.gov/gene/5660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001593 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA PTPRJ http://www.ncbi.nlm.nih.gov/gene/5795 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001594 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA RBMS2P http://www.ncbi.nlm.nih.gov/gene/643427 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001595 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA RNF168 http://www.ncbi.nlm.nih.gov/gene/165918 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001596 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA SMAP2 http://www.ncbi.nlm.nih.gov/gene/64744 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001597 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA STYX http://www.ncbi.nlm.nih.gov/gene/6815 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001598 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA UBXN4 http://www.ncbi.nlm.nih.gov/gene/23190 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001599 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA ZNF585B http://www.ncbi.nlm.nih.gov/gene/92285 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001600 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA ZNF652 http://www.ncbi.nlm.nih.gov/gene/22834 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001601 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART19-5p(ebv-mir-bart19-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004836 BC-1 - Host mRNA ZNF770 http://www.ncbi.nlm.nih.gov/gene/54989 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001602 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-3p(ebv-mir-bart2-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004744 BC-1 - Host mRNA ATG12 http://www.ncbi.nlm.nih.gov/gene/9140 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001603 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-3p(ebv-mir-bart2-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004744 BC-1 - Host mRNA ELK4 http://www.ncbi.nlm.nih.gov/gene/2005 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001604 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-3p(ebv-mir-bart2-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004744 BC-1 - Host mRNA ETNK1 http://www.ncbi.nlm.nih.gov/gene/55500 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001605 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-3p(ebv-mir-bart2-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004744 BC-1 - Host mRNA IER3 http://www.ncbi.nlm.nih.gov/gene/8870 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001606 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-3p(ebv-mir-bart2-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004744 BC-1 - Host mRNA SBNO1 http://www.ncbi.nlm.nih.gov/gene/55206 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001607 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-3p(ebv-mir-bart2-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004744 BC-1 - Host mRNA SMG7 http://www.ncbi.nlm.nih.gov/gene/9887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001608 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-3p(ebv-mir-bart2-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004744 BC-1 - Host mRNA TMED4 http://www.ncbi.nlm.nih.gov/gene/222068 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001609 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-3p(ebv-mir-bart2-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004744 BC-1 - Host mRNA TRAM2 http://www.ncbi.nlm.nih.gov/gene/9697 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001610 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-3p(ebv-mir-bart2-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004744 BC-1 - Host mRNA YIPF6 http://www.ncbi.nlm.nih.gov/gene/286451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001611 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 - - Host mRNA MICB http://www.ncbi.nlm.nih.gov/gene/4277 - Quantitative Real-Time PCR, Luciferase Assay, Western Blot. 20413099 Recently, the activating NK cell ligand MICB was found to be targeted by both ebv-miR-BART2-5p, kshv-miR-K12-7 and hcmvmiR-UL112-1. VHID00001612 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(BART-2-5P) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 - - Host Protein MICB http://www.ncbi.nlm.nih.gov/gene/4277 Downregulation PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets (Table 1).Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV- and EBV-encoded miRNAs. VHID00001613 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(MiR-BART2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 - - Host Protein MICB http://www.ncbi.nlm.nih.gov/gene/4277 Downregulation Dual luciferase reporter assay. 22100165 A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs.MiR-K12-7 and MiR-BART2-5p Are the Viral MiRNAs that Mediate MICB Downregulation.To test whether these two viral miRNAs directly bind to the 3'UTR of MICB, we performed a dual luciferase reporter assay. VHID00001614 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA AADACL1 http://www.ncbi.nlm.nih.gov/gene/57552 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001615 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ABTB2 http://www.ncbi.nlm.nih.gov/gene/25841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001616 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ACADM http://www.ncbi.nlm.nih.gov/gene/34 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001617 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ACSL4 http://www.ncbi.nlm.nih.gov/gene/2182 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001618 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ADAM10 http://www.ncbi.nlm.nih.gov/gene/102 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001619 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ADCY7 http://www.ncbi.nlm.nih.gov/gene/113 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001620 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ADNP2 http://www.ncbi.nlm.nih.gov/gene/22850 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001621 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA AHNAK http://www.ncbi.nlm.nih.gov/gene/79026 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001622 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA AKAP10 http://www.ncbi.nlm.nih.gov/gene/11216 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001623 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA AKAP13 http://www.ncbi.nlm.nih.gov/gene/11214 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001624 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ANXA7 http://www.ncbi.nlm.nih.gov/gene/310 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001625 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA APC http://www.ncbi.nlm.nih.gov/gene/324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001626 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ARPC5 http://www.ncbi.nlm.nih.gov/gene/10092 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001627 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ARPP19 http://www.ncbi.nlm.nih.gov/gene/646227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001628 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ARRDC3 http://www.ncbi.nlm.nih.gov/gene/57561 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001629 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ASH1L http://www.ncbi.nlm.nih.gov/gene/55870 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001630 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ASXL2 http://www.ncbi.nlm.nih.gov/gene/55252 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001631 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ATE1 http://www.ncbi.nlm.nih.gov/gene/11101 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001632 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ATF2 http://www.ncbi.nlm.nih.gov/gene/1386 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001633 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ATG12 http://www.ncbi.nlm.nih.gov/gene/9140 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001634 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ATXN7 http://www.ncbi.nlm.nih.gov/gene/6314 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001635 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA AURKA http://www.ncbi.nlm.nih.gov/gene/6790 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001636 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA BAG3 http://www.ncbi.nlm.nih.gov/gene/9531 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001637 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA BAZ2B http://www.ncbi.nlm.nih.gov/gene/29994 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001638 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA BCAP29 http://www.ncbi.nlm.nih.gov/gene/55973 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001639 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA BCOR http://www.ncbi.nlm.nih.gov/gene/54880 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001640 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA BHLHE22 http://www.ncbi.nlm.nih.gov/gene/27319 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001641 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA BMP2K http://www.ncbi.nlm.nih.gov/gene/55589 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001642 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA BNC2 http://www.ncbi.nlm.nih.gov/gene/54796 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001643 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA BTF3L4 http://www.ncbi.nlm.nih.gov/gene/91408 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001644 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA BTN2A2 http://www.ncbi.nlm.nih.gov/gene/10385 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001645 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA BXDC5 http://www.ncbi.nlm.nih.gov/gene/80135 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001646 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA C1orf109 http://www.ncbi.nlm.nih.gov/gene/54955 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001647 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA C20orf177 http://www.ncbi.nlm.nih.gov/gene/63939 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001648 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA C22orf30 http://www.ncbi.nlm.nih.gov/gene/253143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001649 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA C3orf23 http://www.ncbi.nlm.nih.gov/gene/285343 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001650 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA C3orf38 http://www.ncbi.nlm.nih.gov/gene/285237 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001651 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA C3orf64 http://www.ncbi.nlm.nih.gov/gene/285203 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001652 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA C4orf16 http://www.ncbi.nlm.nih.gov/gene/55435 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001653 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA C5orf24 http://www.ncbi.nlm.nih.gov/gene/134553 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001654 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA C6orf204 http://www.ncbi.nlm.nih.gov/gene/387119 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001655 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA C9orf41 http://www.ncbi.nlm.nih.gov/gene/138199 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001656 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA C9orf97 http://www.ncbi.nlm.nih.gov/gene/158427 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001657 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA CALM2 http://www.ncbi.nlm.nih.gov/gene/808 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001658 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA CAMSAP1L1 http://www.ncbi.nlm.nih.gov/gene/23271 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001659 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA CASP3 http://www.ncbi.nlm.nih.gov/gene/836 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001660 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA CCDC6 http://www.ncbi.nlm.nih.gov/gene/8030 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001661 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001662 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA CD200R1 http://www.ncbi.nlm.nih.gov/gene/131450 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001663 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA CDC2L5 http://www.ncbi.nlm.nih.gov/gene/8621 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001664 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA CHAC2 http://www.ncbi.nlm.nih.gov/gene/494143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001665 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA CLEC2B http://www.ncbi.nlm.nih.gov/gene/9976 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001666 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA CLEC2D http://www.ncbi.nlm.nih.gov/gene/29121 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001667 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA CLIC4 http://www.ncbi.nlm.nih.gov/gene/25932 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001668 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA CLIP1 http://www.ncbi.nlm.nih.gov/gene/6249 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001669 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA CNOT3 http://www.ncbi.nlm.nih.gov/gene/4849 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001670 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA CNOT4 http://www.ncbi.nlm.nih.gov/gene/4850 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001671 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA COMMD2 http://www.ncbi.nlm.nih.gov/gene/51122 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001672 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA CPEB3 http://www.ncbi.nlm.nih.gov/gene/22849 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001673 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA CREBL2 http://www.ncbi.nlm.nih.gov/gene/1389 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001674 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA CRIPT http://www.ncbi.nlm.nih.gov/gene/9419 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001675 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA CTSS http://www.ncbi.nlm.nih.gov/gene/1520 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001676 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA CYLD http://www.ncbi.nlm.nih.gov/gene/1540 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001677 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA CYP4F3 http://www.ncbi.nlm.nih.gov/gene/4051 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001678 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA CYTH3 http://www.ncbi.nlm.nih.gov/gene/9265 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001679 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA DCBLD1 http://www.ncbi.nlm.nih.gov/gene/285761 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001680 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA DCP1A http://www.ncbi.nlm.nih.gov/gene/55802 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001681 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA DDHD2 http://www.ncbi.nlm.nih.gov/gene/23259 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001682 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA DEPDC1 http://www.ncbi.nlm.nih.gov/gene/55635 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001683 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA DNAJB4 http://www.ncbi.nlm.nih.gov/gene/11080 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001684 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA DPP8 http://www.ncbi.nlm.nih.gov/gene/54878 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001685 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA EFR3A http://www.ncbi.nlm.nih.gov/gene/23167 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001686 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA EIF4G3 http://www.ncbi.nlm.nih.gov/gene/8672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001687 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ERGIC2 http://www.ncbi.nlm.nih.gov/gene/51290 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001688 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ETNK1 http://www.ncbi.nlm.nih.gov/gene/55500 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001689 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA EYA1 http://www.ncbi.nlm.nih.gov/gene/2138 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001690 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA FAM126B http://www.ncbi.nlm.nih.gov/gene/285172 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001691 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA FAM136A http://www.ncbi.nlm.nih.gov/gene/84908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001692 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA FAM160B1 http://www.ncbi.nlm.nih.gov/gene/57700 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001693 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA FAM63B http://www.ncbi.nlm.nih.gov/gene/54629 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001694 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA FDX1 http://www.ncbi.nlm.nih.gov/gene/2230 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001695 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA FGF2 http://www.ncbi.nlm.nih.gov/gene/2247 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001696 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA FGFR1OP2 http://www.ncbi.nlm.nih.gov/gene/26127 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001697 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA FH http://www.ncbi.nlm.nih.gov/gene/2271 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001698 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA FNDC3A http://www.ncbi.nlm.nih.gov/gene/22862 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001699 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA FRS2 http://www.ncbi.nlm.nih.gov/gene/10818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001700 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA FZD6 http://www.ncbi.nlm.nih.gov/gene/8323 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001701 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA G3BP1 http://www.ncbi.nlm.nih.gov/gene/10146 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001702 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA GABPA http://www.ncbi.nlm.nih.gov/gene/2551 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001703 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA GALNT5 http://www.ncbi.nlm.nih.gov/gene/11227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001704 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA GBAS http://www.ncbi.nlm.nih.gov/gene/2631 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001705 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA GLCCI1 http://www.ncbi.nlm.nih.gov/gene/113263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001706 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA GOLGA8B http://www.ncbi.nlm.nih.gov/gene/440270 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001707 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA GOLT1B http://www.ncbi.nlm.nih.gov/gene/51026 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001708 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA GORAB http://www.ncbi.nlm.nih.gov/gene/92344 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001709 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA GPNMB http://www.ncbi.nlm.nih.gov/gene/10457 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001710 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA GPRIN3 http://www.ncbi.nlm.nih.gov/gene/285513 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001711 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA GSR http://www.ncbi.nlm.nih.gov/gene/2936 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001712 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA GUCY1A3 http://www.ncbi.nlm.nih.gov/gene/2982 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001713 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA HACE1 http://www.ncbi.nlm.nih.gov/gene/57531 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001714 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA HCFC2 http://www.ncbi.nlm.nih.gov/gene/29915 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001715 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA HELZ http://www.ncbi.nlm.nih.gov/gene/9931 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001716 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA HIATL1 http://www.ncbi.nlm.nih.gov/gene/84641 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001717 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA HLA-B http://www.ncbi.nlm.nih.gov/gene/3106 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001718 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA HMGCS1 http://www.ncbi.nlm.nih.gov/gene/3157 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001719 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA HSDL1 http://www.ncbi.nlm.nih.gov/gene/83693 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001720 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA HSPA13 http://www.ncbi.nlm.nih.gov/gene/6782 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001721 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA IREB2 http://www.ncbi.nlm.nih.gov/gene/3658 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001722 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA IRF1 http://www.ncbi.nlm.nih.gov/gene/3659 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001723 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA IRGQ http://www.ncbi.nlm.nih.gov/gene/126298 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001724 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA KIAA1211 http://www.ncbi.nlm.nih.gov/gene/57482 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001725 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA KIAA1383 http://www.ncbi.nlm.nih.gov/gene/54627 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001726 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA KIAA1429 http://www.ncbi.nlm.nih.gov/gene/25962 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001727 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA KIAA1704 http://www.ncbi.nlm.nih.gov/gene/55425 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001728 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA KLHDC10 http://www.ncbi.nlm.nih.gov/gene/23008 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001729 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA LCOR http://www.ncbi.nlm.nih.gov/gene/84458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001730 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA LIN54 http://www.ncbi.nlm.nih.gov/gene/132660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001731 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA LRRC58 http://www.ncbi.nlm.nih.gov/gene/116064 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001732 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA LRRC8B http://www.ncbi.nlm.nih.gov/gene/23507 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001733 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA LSM14A http://www.ncbi.nlm.nih.gov/gene/26065 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001734 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA LSM14B http://www.ncbi.nlm.nih.gov/gene/149986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001735 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA LTV1 http://www.ncbi.nlm.nih.gov/gene/100128319 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001736 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA LYSMD3 http://www.ncbi.nlm.nih.gov/gene/116068 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001737 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA MAK16 http://www.ncbi.nlm.nih.gov/gene/84549 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001738 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA MAP3K2 http://www.ncbi.nlm.nih.gov/gene/10746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001739 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA MBTD1 http://www.ncbi.nlm.nih.gov/gene/54799 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001740 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA MDM2 http://www.ncbi.nlm.nih.gov/gene/4193 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001741 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA MECP2 http://www.ncbi.nlm.nih.gov/gene/4204 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001742 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA MFSD5 http://www.ncbi.nlm.nih.gov/gene/84975 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001743 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA MOBKL1A http://www.ncbi.nlm.nih.gov/gene/92597 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001744 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA MTMR12 http://www.ncbi.nlm.nih.gov/gene/54545 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001745 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA MXD1 http://www.ncbi.nlm.nih.gov/gene/4084 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001746 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA NOB1 http://www.ncbi.nlm.nih.gov/gene/100132364 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001747 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA NOTCH2NL http://www.ncbi.nlm.nih.gov/gene/388677 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001748 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA NR2C2 http://www.ncbi.nlm.nih.gov/gene/7182 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001749 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA NUFIP2 http://www.ncbi.nlm.nih.gov/gene/57532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001750 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA NUPL1 http://www.ncbi.nlm.nih.gov/gene/9818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001751 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ORC2L http://www.ncbi.nlm.nih.gov/gene/4999 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001752 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA OTUD1 http://www.ncbi.nlm.nih.gov/gene/220213 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001753 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA OTUD4 http://www.ncbi.nlm.nih.gov/gene/54726 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001754 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA PAFAH1B1 http://www.ncbi.nlm.nih.gov/gene/5048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001755 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA PAIP2 http://www.ncbi.nlm.nih.gov/gene/51247 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001756 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA PANK3 http://www.ncbi.nlm.nih.gov/gene/79646 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001757 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA PCDH17 http://www.ncbi.nlm.nih.gov/gene/27253 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001758 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA PDE7A http://www.ncbi.nlm.nih.gov/gene/5150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001759 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA PEBP1 http://www.ncbi.nlm.nih.gov/gene/5037 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001760 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA PELI1 http://www.ncbi.nlm.nih.gov/gene/57162 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001761 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA PJA2 http://www.ncbi.nlm.nih.gov/gene/9867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001762 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA PKIA http://www.ncbi.nlm.nih.gov/gene/5569 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001763 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA PNN http://www.ncbi.nlm.nih.gov/gene/5411 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001764 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA PNPLA4 http://www.ncbi.nlm.nih.gov/gene/8228 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001765 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA PPP2R5C http://www.ncbi.nlm.nih.gov/gene/5527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001766 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA PPP4R2 http://www.ncbi.nlm.nih.gov/gene/151987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001767 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA PRKAA1 http://www.ncbi.nlm.nih.gov/gene/5562 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001768 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA PRKAB2 http://www.ncbi.nlm.nih.gov/gene/5565 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001769 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA PSIP1 http://www.ncbi.nlm.nih.gov/gene/11168 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001770 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA PTAR1 http://www.ncbi.nlm.nih.gov/gene/375743 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001771 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA PTEN http://www.ncbi.nlm.nih.gov/gene/11191 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001772 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA PTPN4 http://www.ncbi.nlm.nih.gov/gene/5775 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001773 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA PTPN9 http://www.ncbi.nlm.nih.gov/gene/5780 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001774 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA PURB http://www.ncbi.nlm.nih.gov/gene/5814 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001775 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA QSER1 http://www.ncbi.nlm.nih.gov/gene/79832 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001776 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA RAD23B http://www.ncbi.nlm.nih.gov/gene/5887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001777 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA RAD51AP1 http://www.ncbi.nlm.nih.gov/gene/10635 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001778 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA RAPH1 http://www.ncbi.nlm.nih.gov/gene/65059 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001779 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA RBBP8 http://www.ncbi.nlm.nih.gov/gene/5932 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001780 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA RC3H2 http://www.ncbi.nlm.nih.gov/gene/54542 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001781 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA REV3L http://www.ncbi.nlm.nih.gov/gene/5980 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001782 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA RFC2 http://www.ncbi.nlm.nih.gov/gene/5982 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001783 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA RFFL http://www.ncbi.nlm.nih.gov/gene/117584 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001784 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA RFX7 http://www.ncbi.nlm.nih.gov/gene/64864 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001785 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA RHPN2 http://www.ncbi.nlm.nih.gov/gene/85415 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001786 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA RNF168 http://www.ncbi.nlm.nih.gov/gene/165918 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001787 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA RNF2 http://www.ncbi.nlm.nih.gov/gene/6045 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001788 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA RPL36AL http://www.ncbi.nlm.nih.gov/gene/6166 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001789 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA RRAGC http://www.ncbi.nlm.nih.gov/gene/64121 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001790 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA RRN3 http://www.ncbi.nlm.nih.gov/gene/54700 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001791 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA RUFY2 http://www.ncbi.nlm.nih.gov/gene/55680 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001792 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA SACM1L http://www.ncbi.nlm.nih.gov/gene/22908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001793 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA SCOC http://www.ncbi.nlm.nih.gov/gene/60592 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001794 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA SEMA7A http://www.ncbi.nlm.nih.gov/gene/8482 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001795 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA SFRS15 http://www.ncbi.nlm.nih.gov/gene/57466 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001796 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA SFXN1 http://www.ncbi.nlm.nih.gov/gene/94081 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001797 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA SHCBP1 http://www.ncbi.nlm.nih.gov/gene/79801 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001798 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA SIAH1 http://www.ncbi.nlm.nih.gov/gene/6477 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001799 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA SIKE1 http://www.ncbi.nlm.nih.gov/gene/80143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001800 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA SIX4 http://www.ncbi.nlm.nih.gov/gene/51804 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001801 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA SLC22A23 http://www.ncbi.nlm.nih.gov/gene/63027 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001802 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA SLC31A1 http://www.ncbi.nlm.nih.gov/gene/1317 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001803 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA SLC39A10 http://www.ncbi.nlm.nih.gov/gene/57181 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001804 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA SLC5A3 http://www.ncbi.nlm.nih.gov/gene/6526 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001805 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA SMAD2 http://www.ncbi.nlm.nih.gov/gene/4087 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001806 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA SMC3 http://www.ncbi.nlm.nih.gov/gene/9126 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001807 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA SNX16 http://www.ncbi.nlm.nih.gov/gene/64089 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001808 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA SP100 http://www.ncbi.nlm.nih.gov/gene/6672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001809 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA SPCS3 http://www.ncbi.nlm.nih.gov/gene/60559 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001810 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA SPRED1 http://www.ncbi.nlm.nih.gov/gene/161742 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001811 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA STAM2 http://www.ncbi.nlm.nih.gov/gene/10254 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001812 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA STK3 http://www.ncbi.nlm.nih.gov/gene/6788 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001813 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA STX6 http://www.ncbi.nlm.nih.gov/gene/10228 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001814 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA SYNCRIP http://www.ncbi.nlm.nih.gov/gene/10492 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001815 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA TANK http://www.ncbi.nlm.nih.gov/gene/10010 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001816 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA TAP2 http://www.ncbi.nlm.nih.gov/gene/6891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001817 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA TBRG1 http://www.ncbi.nlm.nih.gov/gene/84897 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001818 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA TCF3 http://www.ncbi.nlm.nih.gov/gene/6929 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001819 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA TET2 http://www.ncbi.nlm.nih.gov/gene/54790 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001820 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA TFDP1 http://www.ncbi.nlm.nih.gov/gene/7027 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001821 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA TLK1 http://www.ncbi.nlm.nih.gov/gene/9874 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001822 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA TM7SF3 http://www.ncbi.nlm.nih.gov/gene/51768 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001823 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA TM9SF3 http://www.ncbi.nlm.nih.gov/gene/56889 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001824 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA TMBIM6 http://www.ncbi.nlm.nih.gov/gene/7009 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001825 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA TMEM168 http://www.ncbi.nlm.nih.gov/gene/64418 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001826 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA TMEM30A http://www.ncbi.nlm.nih.gov/gene/55754 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001827 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA TMSB10 http://www.ncbi.nlm.nih.gov/gene/9168 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001828 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA TOR1AIP2 http://www.ncbi.nlm.nih.gov/gene/163590 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001829 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA TP53INP1 http://www.ncbi.nlm.nih.gov/gene/94241 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001830 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA TPD52 http://www.ncbi.nlm.nih.gov/gene/7163 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001831 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA TRAPPC3 http://www.ncbi.nlm.nih.gov/gene/27095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001832 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA TTC37 http://www.ncbi.nlm.nih.gov/gene/9652 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001833 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA TWISTNB http://www.ncbi.nlm.nih.gov/gene/221830 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001834 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA UBE2Z http://www.ncbi.nlm.nih.gov/gene/65264 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001835 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA UBXN2A http://www.ncbi.nlm.nih.gov/gene/165324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001836 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA UFM1 http://www.ncbi.nlm.nih.gov/gene/51569 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001837 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA UHMK1 http://www.ncbi.nlm.nih.gov/gene/127933 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001838 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA UPF1 http://www.ncbi.nlm.nih.gov/gene/5976 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001839 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA USP14 http://www.ncbi.nlm.nih.gov/gene/9097 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001840 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA USP37 http://www.ncbi.nlm.nih.gov/gene/57695 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001841 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA WDR37 http://www.ncbi.nlm.nih.gov/gene/22884 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001842 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA WDR41 http://www.ncbi.nlm.nih.gov/gene/55255 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001843 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA WIPF2 http://www.ncbi.nlm.nih.gov/gene/147179 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001844 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA XRCC5 http://www.ncbi.nlm.nih.gov/gene/7520 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001845 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA YEATS4 http://www.ncbi.nlm.nih.gov/gene/8089 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001846 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA YWHAG http://www.ncbi.nlm.nih.gov/gene/7532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001847 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZAK http://www.ncbi.nlm.nih.gov/gene/51776 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001848 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZBTB33 http://www.ncbi.nlm.nih.gov/gene/10009 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001849 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZBTB37 http://www.ncbi.nlm.nih.gov/gene/84614 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001850 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZFAND3 http://www.ncbi.nlm.nih.gov/gene/60685 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001851 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZFYVE20 http://www.ncbi.nlm.nih.gov/gene/64145 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001852 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF100 http://www.ncbi.nlm.nih.gov/gene/163227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001853 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF124 http://www.ncbi.nlm.nih.gov/gene/7678 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001854 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF146 http://www.ncbi.nlm.nih.gov/gene/7705 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001855 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF180 http://www.ncbi.nlm.nih.gov/gene/7733 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001856 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF197 http://www.ncbi.nlm.nih.gov/gene/10168 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001857 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF22 http://www.ncbi.nlm.nih.gov/gene/7570 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001858 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF238 http://www.ncbi.nlm.nih.gov/gene/10472 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001859 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF24 http://www.ncbi.nlm.nih.gov/gene/7572 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001860 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF254 http://www.ncbi.nlm.nih.gov/gene/9534 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001861 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF280B http://www.ncbi.nlm.nih.gov/gene/140883 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001862 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF331 http://www.ncbi.nlm.nih.gov/gene/55422 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001863 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF37A http://www.ncbi.nlm.nih.gov/gene/7587 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001864 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF436 http://www.ncbi.nlm.nih.gov/gene/80818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001865 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF451 http://www.ncbi.nlm.nih.gov/gene/26036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001866 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF460 http://www.ncbi.nlm.nih.gov/gene/10794 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001867 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF507 http://www.ncbi.nlm.nih.gov/gene/22847 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001868 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF518A http://www.ncbi.nlm.nih.gov/gene/9849 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001869 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF614 http://www.ncbi.nlm.nih.gov/gene/80110 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001870 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF624 http://www.ncbi.nlm.nih.gov/gene/57547 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001871 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF626 http://www.ncbi.nlm.nih.gov/gene/199777 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001872 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF652 http://www.ncbi.nlm.nih.gov/gene/22834 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001873 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF664 http://www.ncbi.nlm.nih.gov/gene/144348 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001874 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF676 http://www.ncbi.nlm.nih.gov/gene/163223 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001875 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF714 http://www.ncbi.nlm.nih.gov/gene/148206 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001876 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF724P http://www.ncbi.nlm.nih.gov/gene/440519 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001877 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF770 http://www.ncbi.nlm.nih.gov/gene/54989 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001878 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF772 http://www.ncbi.nlm.nih.gov/gene/400720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001879 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF805 http://www.ncbi.nlm.nih.gov/gene/390980 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001880 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF828 http://www.ncbi.nlm.nih.gov/gene/283489 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001881 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZNF92 http://www.ncbi.nlm.nih.gov/gene/168374 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001882 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 BC-1 - Host mRNA ZWILCH http://www.ncbi.nlm.nih.gov/gene/55055 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001883 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA AADACL1 http://www.ncbi.nlm.nih.gov/gene/57552 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001884 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA ACADM http://www.ncbi.nlm.nih.gov/gene/34 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001885 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA ADNP http://www.ncbi.nlm.nih.gov/gene/23394 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001886 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA ADNP2 http://www.ncbi.nlm.nih.gov/gene/22850 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001887 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA AKAP10 http://www.ncbi.nlm.nih.gov/gene/11216 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001888 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA ATP8A1 http://www.ncbi.nlm.nih.gov/gene/10396 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001889 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA BCOR http://www.ncbi.nlm.nih.gov/gene/54880 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001890 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA C17orf80 http://www.ncbi.nlm.nih.gov/gene/55028 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001891 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA C1orf109 http://www.ncbi.nlm.nih.gov/gene/54955 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001892 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA C3orf38 http://www.ncbi.nlm.nih.gov/gene/285237 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001893 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA CALM2 http://www.ncbi.nlm.nih.gov/gene/808 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001894 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA CDC2L5 http://www.ncbi.nlm.nih.gov/gene/8621 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001895 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA CDC73 http://www.ncbi.nlm.nih.gov/gene/79577 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001896 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA CDK6 http://www.ncbi.nlm.nih.gov/gene/1021 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001897 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA CLIC4 http://www.ncbi.nlm.nih.gov/gene/25932 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001898 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA CREB3L2 http://www.ncbi.nlm.nih.gov/gene/64764 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001899 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA CYLD http://www.ncbi.nlm.nih.gov/gene/1540 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001900 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA CYTH3 http://www.ncbi.nlm.nih.gov/gene/9265 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001901 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA DICER1 http://www.ncbi.nlm.nih.gov/gene/23405 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001902 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA DIS3 http://www.ncbi.nlm.nih.gov/gene/22894 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001903 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA DMXL1 http://www.ncbi.nlm.nih.gov/gene/1657 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001904 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA E2F3 http://www.ncbi.nlm.nih.gov/gene/1871 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001905 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA EFCAB14-AS1(KIAA0494) - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001906 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA ERO1LB http://www.ncbi.nlm.nih.gov/gene/56605 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001907 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA ETNK1 http://www.ncbi.nlm.nih.gov/gene/55500 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001908 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA FAM174A http://www.ncbi.nlm.nih.gov/gene/345757 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001909 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA FAM49B http://www.ncbi.nlm.nih.gov/gene/51571 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001910 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA FAM63B http://www.ncbi.nlm.nih.gov/gene/54629 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001911 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA FBXO28 http://www.ncbi.nlm.nih.gov/gene/23219 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001912 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA FNDC3A http://www.ncbi.nlm.nih.gov/gene/22862 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001913 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA G3BP1 http://www.ncbi.nlm.nih.gov/gene/10146 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001914 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA GLT8D3 http://www.ncbi.nlm.nih.gov/gene/283464 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001915 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA GPX1 http://www.ncbi.nlm.nih.gov/gene/2876 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001916 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA HCFC2 http://www.ncbi.nlm.nih.gov/gene/29915 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001917 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA HERC5 http://www.ncbi.nlm.nih.gov/gene/51191 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001918 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA HIATL1 http://www.ncbi.nlm.nih.gov/gene/84641 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001919 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA HIVEP2 http://www.ncbi.nlm.nih.gov/gene/3097 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001920 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA HLA-B http://www.ncbi.nlm.nih.gov/gene/3106 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001921 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA IRF1 http://www.ncbi.nlm.nih.gov/gene/3659 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001922 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA KIAA1432 http://www.ncbi.nlm.nih.gov/gene/57589 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001923 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA KIF5B http://www.ncbi.nlm.nih.gov/gene/3799 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001924 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA KLHDC10 http://www.ncbi.nlm.nih.gov/gene/23008 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001925 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA LAP3 http://www.ncbi.nlm.nih.gov/gene/51056 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001926 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA LEPROTL1 http://www.ncbi.nlm.nih.gov/gene/23484 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001927 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA MAML2 http://www.ncbi.nlm.nih.gov/gene/84441 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001928 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA MEF2A http://www.ncbi.nlm.nih.gov/gene/4205 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001929 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA MFSD5 http://www.ncbi.nlm.nih.gov/gene/84975 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001930 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA MOBKL1A http://www.ncbi.nlm.nih.gov/gene/92597 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001931 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA NR2C2 http://www.ncbi.nlm.nih.gov/gene/7182 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001932 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA NUPL1 http://www.ncbi.nlm.nih.gov/gene/9818 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001933 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA OTUD1 http://www.ncbi.nlm.nih.gov/gene/220213 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001934 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA PAFAH1B1 http://www.ncbi.nlm.nih.gov/gene/5048 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001935 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA PDE7A http://www.ncbi.nlm.nih.gov/gene/5150 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001936 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA PDLIM1 http://www.ncbi.nlm.nih.gov/gene/9124 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001937 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA PDLIM5 http://www.ncbi.nlm.nih.gov/gene/10611 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001938 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA PJA2 http://www.ncbi.nlm.nih.gov/gene/9867 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001939 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA PPP2R2D http://www.ncbi.nlm.nih.gov/gene/55844 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001940 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA PRKCB http://www.ncbi.nlm.nih.gov/gene/5579 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001941 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA PSIP1 http://www.ncbi.nlm.nih.gov/gene/11168 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001942 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA PSMA4 http://www.ncbi.nlm.nih.gov/gene/5685 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001943 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA QSER1 http://www.ncbi.nlm.nih.gov/gene/79832 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001944 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA RBM26 http://www.ncbi.nlm.nih.gov/gene/64062 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001945 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA RC3H2 http://www.ncbi.nlm.nih.gov/gene/54542 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001946 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA REEP3 http://www.ncbi.nlm.nih.gov/gene/221035 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001947 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA RFFL http://www.ncbi.nlm.nih.gov/gene/117584 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001948 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA RFX7 http://www.ncbi.nlm.nih.gov/gene/64864 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001949 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA RLF http://www.ncbi.nlm.nih.gov/gene/6018 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001950 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA RNF2 http://www.ncbi.nlm.nih.gov/gene/6045 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001951 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA RPL30 http://www.ncbi.nlm.nih.gov/gene/6156 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001952 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA RRN3 http://www.ncbi.nlm.nih.gov/gene/54700 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001953 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA RUFY2 http://www.ncbi.nlm.nih.gov/gene/55680 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001954 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA SCOC http://www.ncbi.nlm.nih.gov/gene/60592 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001955 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA SEC23A http://www.ncbi.nlm.nih.gov/gene/10484 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001956 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA SEC31A http://www.ncbi.nlm.nih.gov/gene/22872 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001957 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA SERBP1 http://www.ncbi.nlm.nih.gov/gene/26135 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001958 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA SHCBP1 http://www.ncbi.nlm.nih.gov/gene/79801 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001959 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA SIPA1L1 http://www.ncbi.nlm.nih.gov/gene/26037 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001960 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA SLC31A1 http://www.ncbi.nlm.nih.gov/gene/1317 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001961 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA SLFN13 http://www.ncbi.nlm.nih.gov/gene/146857 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001962 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA SP100 http://www.ncbi.nlm.nih.gov/gene/6672 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001963 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA STAU1 http://www.ncbi.nlm.nih.gov/gene/6780 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001964 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA THUMPD1 http://www.ncbi.nlm.nih.gov/gene/55623 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001965 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA TM7SF3 http://www.ncbi.nlm.nih.gov/gene/51768 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001966 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA TMEM30A http://www.ncbi.nlm.nih.gov/gene/55754 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001967 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA TMSB10 http://www.ncbi.nlm.nih.gov/gene/9168 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001968 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA TPD52 http://www.ncbi.nlm.nih.gov/gene/7163 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001969 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA TRAPPC3 http://www.ncbi.nlm.nih.gov/gene/27095 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001970 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA TRIP11 http://www.ncbi.nlm.nih.gov/gene/9321 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001971 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA UCHL1 http://www.ncbi.nlm.nih.gov/gene/7345 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001972 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA USP37 http://www.ncbi.nlm.nih.gov/gene/57695 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001973 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA USP45 http://www.ncbi.nlm.nih.gov/gene/85015 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001974 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA YES1 http://www.ncbi.nlm.nih.gov/gene/7525 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001975 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA ZAK http://www.ncbi.nlm.nih.gov/gene/51776 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001976 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA ZBTB1 http://www.ncbi.nlm.nih.gov/gene/22890 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001977 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA ZBTB33 http://www.ncbi.nlm.nih.gov/gene/10009 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001978 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA ZBTB44 http://www.ncbi.nlm.nih.gov/gene/29068 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001979 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA ZNF100 http://www.ncbi.nlm.nih.gov/gene/163227 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001980 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA ZNF436 http://www.ncbi.nlm.nih.gov/gene/80818 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001981 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA ZNF652 http://www.ncbi.nlm.nih.gov/gene/22834 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001982 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA ZNF828 http://www.ncbi.nlm.nih.gov/gene/283489 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00001983 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(ebv-mir-bart2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Lymphoblastoid cell lines - Host mRNA ZNFX1 http://www.ncbi.nlm.nih.gov/gene/57169 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00001984 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(miR-BART2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 - - Host Protein MICB http://www.ncbi.nlm.nih.gov/gene/4277 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00001985 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(miR-BART2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 - - Host mRNA MICB http://www.ncbi.nlm.nih.gov/gene/4277 - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VHID00001986 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART2-5p(miR-BART2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 Natural Killer (NK) cell - Host mRNA MICB http://www.ncbi.nlm.nih.gov/gene/4277 Downregulation Western Blot,Quantitative Real-Time PCR, Luciferase Assay. 19380116 KSHV and EBV Downregulate MICB Expression via a MiRNA-Based Translational Repression Mechanism.MiR-K12-7 and MiR-BART2-5p Directly Bind to the 3'UTR of MICB. VHID00001987 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ABI2 http://www.ncbi.nlm.nih.gov/gene/10152 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001988 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ACBD5 http://www.ncbi.nlm.nih.gov/gene/91452 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001989 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ACSL1 http://www.ncbi.nlm.nih.gov/gene/2180 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001990 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA AHNAK http://www.ncbi.nlm.nih.gov/gene/79026 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001991 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA AKAP11 http://www.ncbi.nlm.nih.gov/gene/11215 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001992 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ALDH1B1 http://www.ncbi.nlm.nih.gov/gene/219 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001993 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA AMD1 http://www.ncbi.nlm.nih.gov/gene/262 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001994 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ANKRD13B http://www.ncbi.nlm.nih.gov/gene/124930 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001995 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ARD1B http://www.ncbi.nlm.nih.gov/gene/84779 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001996 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ARID4B http://www.ncbi.nlm.nih.gov/gene/51742 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001997 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ARL8B http://www.ncbi.nlm.nih.gov/gene/55207 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001998 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ASF1A http://www.ncbi.nlm.nih.gov/gene/25842 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00001999 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ASF1B http://www.ncbi.nlm.nih.gov/gene/55723 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002000 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA B4GALT6 http://www.ncbi.nlm.nih.gov/gene/9331 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002001 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA BAG5 http://www.ncbi.nlm.nih.gov/gene/9529 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002002 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA BAZ2A http://www.ncbi.nlm.nih.gov/gene/11176 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002003 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA BRWD1 http://www.ncbi.nlm.nih.gov/gene/54014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002004 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA BTBD1 http://www.ncbi.nlm.nih.gov/gene/53339 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002005 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA C10orf118 http://www.ncbi.nlm.nih.gov/gene/55088 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002006 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA C12orf51 http://www.ncbi.nlm.nih.gov/gene/283450 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002007 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA C17orf49 http://www.ncbi.nlm.nih.gov/gene/124944 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002008 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA C19orf10 http://www.ncbi.nlm.nih.gov/gene/56005 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002009 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA C20orf27 http://www.ncbi.nlm.nih.gov/gene/54976 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002010 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA C6orf167 http://www.ncbi.nlm.nih.gov/gene/253714 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002011 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA CA2 http://www.ncbi.nlm.nih.gov/gene/760 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002012 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA CAND1 http://www.ncbi.nlm.nih.gov/gene/55832 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002013 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA CAPZA1 http://www.ncbi.nlm.nih.gov/gene/829 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002014 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA CARD8 http://www.ncbi.nlm.nih.gov/gene/22900 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002015 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA CASP3 http://www.ncbi.nlm.nih.gov/gene/836 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002016 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA CCDC132 http://www.ncbi.nlm.nih.gov/gene/55610 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002017 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA CDK6 http://www.ncbi.nlm.nih.gov/gene/1021 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002018 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA CDV3 http://www.ncbi.nlm.nih.gov/gene/55573 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002019 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA CEP110 http://www.ncbi.nlm.nih.gov/gene/11064 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002020 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA CERK http://www.ncbi.nlm.nih.gov/gene/64781 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002021 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA CLDND1 http://www.ncbi.nlm.nih.gov/gene/56650 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002022 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA CLPX http://www.ncbi.nlm.nih.gov/gene/10845 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002023 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA COBLL1 http://www.ncbi.nlm.nih.gov/gene/22837 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002024 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA COPZ1 http://www.ncbi.nlm.nih.gov/gene/22818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002025 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA COX11 http://www.ncbi.nlm.nih.gov/gene/1353 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002026 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA CPEB3 http://www.ncbi.nlm.nih.gov/gene/22849 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002027 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA CRCP http://www.ncbi.nlm.nih.gov/gene/27297 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002028 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA CRK http://www.ncbi.nlm.nih.gov/gene/1398 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002029 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA CSDE1 http://www.ncbi.nlm.nih.gov/gene/7812 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002030 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA CSNK1G2 http://www.ncbi.nlm.nih.gov/gene/1455 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002031 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA CSNK2A1 http://www.ncbi.nlm.nih.gov/gene/283106 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002032 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA CSRNP2 http://www.ncbi.nlm.nih.gov/gene/81566 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002033 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA CUGBP1 http://www.ncbi.nlm.nih.gov/gene/10658 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002034 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA CUL4A http://www.ncbi.nlm.nih.gov/gene/8451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002035 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA DCTN4 http://www.ncbi.nlm.nih.gov/gene/51164 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002036 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA DICER1 http://www.ncbi.nlm.nih.gov/gene/23405 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002037 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA DNMT3A http://www.ncbi.nlm.nih.gov/gene/1788 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002038 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA DPY19L4 http://www.ncbi.nlm.nih.gov/gene/286148 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002039 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA DSTN http://www.ncbi.nlm.nih.gov/gene/11034 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002040 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA EIF1AD http://www.ncbi.nlm.nih.gov/gene/84285 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002041 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA EIF4EBP2 http://www.ncbi.nlm.nih.gov/gene/1979 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002042 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ELK4 http://www.ncbi.nlm.nih.gov/gene/2005 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002043 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ENPP4 http://www.ncbi.nlm.nih.gov/gene/22875 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002044 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA EPDR1 http://www.ncbi.nlm.nih.gov/gene/54749 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002045 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ETNK1 http://www.ncbi.nlm.nih.gov/gene/55500 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002046 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA FAM160B1 http://www.ncbi.nlm.nih.gov/gene/57700 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002047 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA FBN1 http://www.ncbi.nlm.nih.gov/gene/2200 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002048 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA FNDC3A http://www.ncbi.nlm.nih.gov/gene/22862 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002049 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA FNDC3B http://www.ncbi.nlm.nih.gov/gene/64778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002050 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA FOXP2 http://www.ncbi.nlm.nih.gov/gene/93986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002051 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA FZD5 http://www.ncbi.nlm.nih.gov/gene/7855 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002052 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA GAB1 http://www.ncbi.nlm.nih.gov/gene/2549 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002053 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA GABPA http://www.ncbi.nlm.nih.gov/gene/2551 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002054 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA GGA2 http://www.ncbi.nlm.nih.gov/gene/23062 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002055 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA GIT2 http://www.ncbi.nlm.nih.gov/gene/9815 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002056 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA GTF3C4 http://www.ncbi.nlm.nih.gov/gene/9329 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002057 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA HAT1 http://www.ncbi.nlm.nih.gov/gene/8520 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002058 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA HAUS5 http://www.ncbi.nlm.nih.gov/gene/23354 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002059 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA HBP1 http://www.ncbi.nlm.nih.gov/gene/26959 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002060 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA HDAC4 http://www.ncbi.nlm.nih.gov/gene/9759 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002061 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA HIF1AN http://www.ncbi.nlm.nih.gov/gene/55662 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002062 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA HIST1H2BF http://www.ncbi.nlm.nih.gov/gene/8343 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002063 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA HMGCS1 http://www.ncbi.nlm.nih.gov/gene/3157 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002064 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA IDE http://www.ncbi.nlm.nih.gov/gene/3416 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002065 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA JHDM1D http://www.ncbi.nlm.nih.gov/gene/80853 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002066 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA JMJD1C http://www.ncbi.nlm.nih.gov/gene/221037 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002067 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA JMY http://www.ncbi.nlm.nih.gov/gene/133746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002068 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA KATNAL1 http://www.ncbi.nlm.nih.gov/gene/84056 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002069 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA KDM4A http://www.ncbi.nlm.nih.gov/gene/9682 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002070 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA KIAA0895 http://www.ncbi.nlm.nih.gov/gene/23366 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002071 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA KIAA0907 http://www.ncbi.nlm.nih.gov/gene/22889 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002072 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA KIAA1712 http://www.ncbi.nlm.nih.gov/gene/80817 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002073 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA KIAA2018 http://www.ncbi.nlm.nih.gov/gene/205717 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002074 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA KPNA5 http://www.ncbi.nlm.nih.gov/gene/3841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002075 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA LARP1 http://www.ncbi.nlm.nih.gov/gene/23367 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002076 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA LMBR1 http://www.ncbi.nlm.nih.gov/gene/64327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002077 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA LRRC57 http://www.ncbi.nlm.nih.gov/gene/255252 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002078 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA LTV1 http://www.ncbi.nlm.nih.gov/gene/100128319 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002079 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA LZIC http://www.ncbi.nlm.nih.gov/gene/84328 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002080 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA MACROD2 http://www.ncbi.nlm.nih.gov/gene/140733 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002081 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA MAT2A http://www.ncbi.nlm.nih.gov/gene/4144 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002082 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA MBNL1 http://www.ncbi.nlm.nih.gov/gene/4154 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002083 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA MBNL2 http://www.ncbi.nlm.nih.gov/gene/10150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002084 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ME2 http://www.ncbi.nlm.nih.gov/gene/4200 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002085 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA MED23 http://www.ncbi.nlm.nih.gov/gene/9439 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002086 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA MFAP3 http://www.ncbi.nlm.nih.gov/gene/4238 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002087 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA MGAT4A http://www.ncbi.nlm.nih.gov/gene/11320 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002088 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA MIDN http://www.ncbi.nlm.nih.gov/gene/90007 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002089 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA MLL http://www.ncbi.nlm.nih.gov/gene/4297 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002090 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA MLL5 http://www.ncbi.nlm.nih.gov/gene/55904 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002091 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA MLLT6 http://www.ncbi.nlm.nih.gov/gene/4302 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002092 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA MORN2 http://www.ncbi.nlm.nih.gov/gene/729967 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002093 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA MPHOSPH8 http://www.ncbi.nlm.nih.gov/gene/54737 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002094 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA MTA3 http://www.ncbi.nlm.nih.gov/gene/57504 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002095 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA N4BP2L1 http://www.ncbi.nlm.nih.gov/gene/90634 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002096 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA NAP1L5 http://www.ncbi.nlm.nih.gov/gene/266812 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002097 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA NCBP2 http://www.ncbi.nlm.nih.gov/gene/22916 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002098 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA NCOR1 http://www.ncbi.nlm.nih.gov/gene/9611 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002099 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA NDUFB2 http://www.ncbi.nlm.nih.gov/gene/4708 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002100 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002101 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA NFS1 http://www.ncbi.nlm.nih.gov/gene/9054 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002102 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA NONO http://www.ncbi.nlm.nih.gov/gene/4841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002103 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA NOTCH2 http://www.ncbi.nlm.nih.gov/gene/4853 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002104 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA NR3C1 http://www.ncbi.nlm.nih.gov/gene/2908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002105 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA NUFIP2 http://www.ncbi.nlm.nih.gov/gene/57532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002106 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA OCIAD1 http://www.ncbi.nlm.nih.gov/gene/54940 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002107 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA OSGIN2 http://www.ncbi.nlm.nih.gov/gene/734 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002108 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA OTUD1 http://www.ncbi.nlm.nih.gov/gene/220213 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002109 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PAK2 http://www.ncbi.nlm.nih.gov/gene/5062 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002110 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PALM2-AKAP2 http://www.ncbi.nlm.nih.gov/gene/114299 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002111 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PCGF5 http://www.ncbi.nlm.nih.gov/gene/84333 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002112 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PER2 http://www.ncbi.nlm.nih.gov/gene/8864 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002113 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PHLPP2 http://www.ncbi.nlm.nih.gov/gene/23035 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002114 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PIGM http://www.ncbi.nlm.nih.gov/gene/93183 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002115 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PIK3C2A http://www.ncbi.nlm.nih.gov/gene/5286 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002116 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PIK3C2B http://www.ncbi.nlm.nih.gov/gene/5287 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002117 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PIKFYVE http://www.ncbi.nlm.nih.gov/gene/200576 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002118 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PLCXD2 http://www.ncbi.nlm.nih.gov/gene/90102 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002119 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PLRG1 http://www.ncbi.nlm.nih.gov/gene/5356 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002120 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PM20D2 http://www.ncbi.nlm.nih.gov/gene/135293 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002121 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PNPT1 http://www.ncbi.nlm.nih.gov/gene/87178 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002122 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA POLR1B http://www.ncbi.nlm.nih.gov/gene/84172 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002123 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA POU2F1 http://www.ncbi.nlm.nih.gov/gene/5451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002124 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PPARA http://www.ncbi.nlm.nih.gov/gene/5465 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002125 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PPIG http://www.ncbi.nlm.nih.gov/gene/9360 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002126 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PPP1CB http://www.ncbi.nlm.nih.gov/gene/245711 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002127 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PPP1CC http://www.ncbi.nlm.nih.gov/gene/5501 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002128 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PPP1R12A http://www.ncbi.nlm.nih.gov/gene/4659 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002129 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PPP2R5C http://www.ncbi.nlm.nih.gov/gene/5527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002130 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PRDM1 http://www.ncbi.nlm.nih.gov/gene/639 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002131 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PRDM10 http://www.ncbi.nlm.nih.gov/gene/56980 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002132 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PREPL http://www.ncbi.nlm.nih.gov/gene/9581 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002133 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PRKAA1 http://www.ncbi.nlm.nih.gov/gene/5562 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002134 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PSTK http://www.ncbi.nlm.nih.gov/gene/118672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002135 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PTBP2 http://www.ncbi.nlm.nih.gov/gene/58155 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002136 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PTCD3 http://www.ncbi.nlm.nih.gov/gene/55037 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002137 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PTTG1IP http://www.ncbi.nlm.nih.gov/gene/754 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002138 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PUM2 http://www.ncbi.nlm.nih.gov/gene/23369 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002139 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA PXMP3 http://www.ncbi.nlm.nih.gov/gene/5828 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002140 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA RAB10 http://www.ncbi.nlm.nih.gov/gene/10890 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002141 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA RAB11A http://www.ncbi.nlm.nih.gov/gene/8766 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002142 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA RAB5B http://www.ncbi.nlm.nih.gov/gene/5869 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002143 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA RAPGEF5 http://www.ncbi.nlm.nih.gov/gene/9771 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002144 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA RBBP9 http://www.ncbi.nlm.nih.gov/gene/10741 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002145 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA RBM4 http://www.ncbi.nlm.nih.gov/gene/10432 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002146 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA RNF111 http://www.ncbi.nlm.nih.gov/gene/54778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002147 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA RNF166 http://www.ncbi.nlm.nih.gov/gene/115992 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002148 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA SCAMP4 http://www.ncbi.nlm.nih.gov/gene/113178 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002149 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA SEC61A2 http://www.ncbi.nlm.nih.gov/gene/55176 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002150 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA SFRS11 http://www.ncbi.nlm.nih.gov/gene/9295 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002151 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA SFT2D2 http://www.ncbi.nlm.nih.gov/gene/375035 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002152 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA SLC19A2 http://www.ncbi.nlm.nih.gov/gene/10560 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002153 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA SLC25A40 http://www.ncbi.nlm.nih.gov/gene/55972 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002154 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA SLC35F5 http://www.ncbi.nlm.nih.gov/gene/80255 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002155 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA SLC38A1 http://www.ncbi.nlm.nih.gov/gene/81539 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002156 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA SLC41A1 http://www.ncbi.nlm.nih.gov/gene/254428 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002157 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA SLC41A3 http://www.ncbi.nlm.nih.gov/gene/54946 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002158 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA SMAD4 http://www.ncbi.nlm.nih.gov/gene/4089 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002159 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA SNX18 http://www.ncbi.nlm.nih.gov/gene/112574 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002160 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA SR140 http://www.ncbi.nlm.nih.gov/gene/23350 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002161 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA SSR1 http://www.ncbi.nlm.nih.gov/gene/6745 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002162 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA STARD4 http://www.ncbi.nlm.nih.gov/gene/134429 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002163 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA STK3 http://www.ncbi.nlm.nih.gov/gene/6788 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002164 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA STRN3 http://www.ncbi.nlm.nih.gov/gene/29966 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002165 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA SUSD2 http://www.ncbi.nlm.nih.gov/gene/56241 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002166 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA SYNJ1 http://www.ncbi.nlm.nih.gov/gene/8867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002167 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA TAF6 http://www.ncbi.nlm.nih.gov/gene/6878 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002168 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA TBCEL http://www.ncbi.nlm.nih.gov/gene/219899 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002169 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA THAP2 http://www.ncbi.nlm.nih.gov/gene/83591 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002170 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA TMOD3 http://www.ncbi.nlm.nih.gov/gene/29766 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002171 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA TNFSF9 http://www.ncbi.nlm.nih.gov/gene/8744 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002172 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA TNPO1 http://www.ncbi.nlm.nih.gov/gene/3842 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002173 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA TOLLIP http://www.ncbi.nlm.nih.gov/gene/54472 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002174 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA TP53INP1 http://www.ncbi.nlm.nih.gov/gene/94241 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002175 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA TRIM4 http://www.ncbi.nlm.nih.gov/gene/89122 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002176 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA TRIO http://www.ncbi.nlm.nih.gov/gene/7204 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002177 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA TSPYL1 http://www.ncbi.nlm.nih.gov/gene/7259 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002178 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA TTC35 http://www.ncbi.nlm.nih.gov/gene/9694 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002179 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA TYW3 http://www.ncbi.nlm.nih.gov/gene/127253 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002180 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA UBFD1 http://www.ncbi.nlm.nih.gov/gene/56061 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002181 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA UBN1 http://www.ncbi.nlm.nih.gov/gene/29855 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002182 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA UBXN2A http://www.ncbi.nlm.nih.gov/gene/165324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002183 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA UHMK1 http://www.ncbi.nlm.nih.gov/gene/127933 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002184 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA UNC84A http://www.ncbi.nlm.nih.gov/gene/23353 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002185 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA UPF1 http://www.ncbi.nlm.nih.gov/gene/5976 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002186 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA USP2 http://www.ncbi.nlm.nih.gov/gene/9099 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002187 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA WDR12 http://www.ncbi.nlm.nih.gov/gene/55759 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002188 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA XPR1 http://www.ncbi.nlm.nih.gov/gene/9213 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002189 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA XRCC5 http://www.ncbi.nlm.nih.gov/gene/7520 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002190 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA YEATS4 http://www.ncbi.nlm.nih.gov/gene/8089 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002191 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ZBTB34 http://www.ncbi.nlm.nih.gov/gene/403341 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002192 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ZBTB6 http://www.ncbi.nlm.nih.gov/gene/10773 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002193 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ZC3H15 http://www.ncbi.nlm.nih.gov/gene/55854 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002194 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ZCCHC8 http://www.ncbi.nlm.nih.gov/gene/55596 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002195 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ZKSCAN1 http://www.ncbi.nlm.nih.gov/gene/7586 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002196 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ZNF124 http://www.ncbi.nlm.nih.gov/gene/7678 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002197 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ZNF468 http://www.ncbi.nlm.nih.gov/gene/90333 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002198 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ZNF543 http://www.ncbi.nlm.nih.gov/gene/125919 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002199 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ZNF551 http://www.ncbi.nlm.nih.gov/gene/90233 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002200 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ZNF592 http://www.ncbi.nlm.nih.gov/gene/9640 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002201 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ZNF644 http://www.ncbi.nlm.nih.gov/gene/84146 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002202 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ZNF655 http://www.ncbi.nlm.nih.gov/gene/79027 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002203 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ZNF680 http://www.ncbi.nlm.nih.gov/gene/340252 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002204 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ZNF700 http://www.ncbi.nlm.nih.gov/gene/90592 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002205 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ZNF765 http://www.ncbi.nlm.nih.gov/gene/91661 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002206 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-3p(ebv-mir-bart20-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003720 BC-1 - Host mRNA ZNF770 http://www.ncbi.nlm.nih.gov/gene/54989 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002207 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA ACTR3 http://www.ncbi.nlm.nih.gov/gene/10096 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002208 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA ADIPOR1 http://www.ncbi.nlm.nih.gov/gene/51094 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002209 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA ATP2B4 http://www.ncbi.nlm.nih.gov/gene/493 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002210 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA BTN2A2 http://www.ncbi.nlm.nih.gov/gene/10385 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002211 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA C11orf59 http://www.ncbi.nlm.nih.gov/gene/55004 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002212 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA C1orf2 http://www.ncbi.nlm.nih.gov/gene/10712 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002213 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA C5orf51 http://www.ncbi.nlm.nih.gov/gene/285636 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002214 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA CD59 http://www.ncbi.nlm.nih.gov/gene/966 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002215 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA CENPB http://www.ncbi.nlm.nih.gov/gene/1059 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002216 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA CHD9 http://www.ncbi.nlm.nih.gov/gene/80205 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002217 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA COX6B1 http://www.ncbi.nlm.nih.gov/gene/1340 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002218 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA DCP2 http://www.ncbi.nlm.nih.gov/gene/167227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002219 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA FAM33A http://www.ncbi.nlm.nih.gov/gene/348235 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002220 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA HIPK1 http://www.ncbi.nlm.nih.gov/gene/204851 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002221 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA IRF1 http://www.ncbi.nlm.nih.gov/gene/3659 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002222 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA ITFG3 http://www.ncbi.nlm.nih.gov/gene/83986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002223 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA KDELR2 http://www.ncbi.nlm.nih.gov/gene/11014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002224 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA KIF5B http://www.ncbi.nlm.nih.gov/gene/3799 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002225 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA MAX http://www.ncbi.nlm.nih.gov/gene/4149 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002226 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA MTHFD2 http://www.ncbi.nlm.nih.gov/gene/10797 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002227 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA NBR1 http://www.ncbi.nlm.nih.gov/gene/4077 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002228 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA NUCKS1 http://www.ncbi.nlm.nih.gov/gene/64710 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002229 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA PAN3 http://www.ncbi.nlm.nih.gov/gene/255967 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002230 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA PRPF38A http://www.ncbi.nlm.nih.gov/gene/84950 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002231 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA PTP4A1 http://www.ncbi.nlm.nih.gov/gene/7803 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002232 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA REST http://www.ncbi.nlm.nih.gov/gene/5978 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002233 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA SEMA3D http://www.ncbi.nlm.nih.gov/gene/223117 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002234 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA SERBP1 http://www.ncbi.nlm.nih.gov/gene/26135 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002235 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA SMG1 http://www.ncbi.nlm.nih.gov/gene/23049 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002236 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA TRIM13 http://www.ncbi.nlm.nih.gov/gene/10206 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002237 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA TRIM14 http://www.ncbi.nlm.nih.gov/gene/9830 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002238 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA TXNRD1 http://www.ncbi.nlm.nih.gov/gene/7296 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002239 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA UBXN2B http://www.ncbi.nlm.nih.gov/gene/137886 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002240 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA UQCRB http://www.ncbi.nlm.nih.gov/gene/442454 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002241 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA ZFP91 http://www.ncbi.nlm.nih.gov/gene/386607 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002242 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA ZNF436 http://www.ncbi.nlm.nih.gov/gene/80818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002243 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA ZSCAN12 http://www.ncbi.nlm.nih.gov/gene/9753 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002244 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(ebv-mir-bart20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 BC-1 - Host mRNA ZSWIM1 http://www.ncbi.nlm.nih.gov/gene/90204 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002245 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(miR-BART20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 lymphoma cell lines - Host Protein TBX21(T-bet) http://www.ncbi.nlm.nih.gov/gene/30009 Downregulation quantitative real-time RT-PCR. 23608226 Taken together, we conclude that EBV-encoded miR-BART20-5p inhibits T-bet translation with secondary suppression of p53 in invasive nasal NK/T-cell lymphoma. VHID00002246 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ABHD4 http://www.ncbi.nlm.nih.gov/gene/63874 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002247 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ABL2 http://www.ncbi.nlm.nih.gov/gene/27 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002248 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ADRB1 http://www.ncbi.nlm.nih.gov/gene/153 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002249 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ANKHD1 http://www.ncbi.nlm.nih.gov/gene/8637 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002250 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ANKIB1 http://www.ncbi.nlm.nih.gov/gene/54467 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002251 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ANKRD28 http://www.ncbi.nlm.nih.gov/gene/23243 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002252 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ANXA5 http://www.ncbi.nlm.nih.gov/gene/308 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002253 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ARHGAP19 http://www.ncbi.nlm.nih.gov/gene/84986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002254 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ARMC8 http://www.ncbi.nlm.nih.gov/gene/25852 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002255 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ARPP19 http://www.ncbi.nlm.nih.gov/gene/646227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002256 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ASF1A http://www.ncbi.nlm.nih.gov/gene/25842 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002257 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ASXL2 http://www.ncbi.nlm.nih.gov/gene/55252 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002258 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ATL2 http://www.ncbi.nlm.nih.gov/gene/64225 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002259 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA BAZ2A http://www.ncbi.nlm.nih.gov/gene/11176 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002260 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA BCOR http://www.ncbi.nlm.nih.gov/gene/54880 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002261 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA BIRC6 http://www.ncbi.nlm.nih.gov/gene/57448 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002262 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA BMI1 http://www.ncbi.nlm.nih.gov/gene/648 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002263 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA BRCA2 http://www.ncbi.nlm.nih.gov/gene/675 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002264 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA C12orf5 http://www.ncbi.nlm.nih.gov/gene/57103 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002265 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA C14orf129 http://www.ncbi.nlm.nih.gov/gene/51527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002266 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA C1orf58 http://www.ncbi.nlm.nih.gov/gene/148362 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002267 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA C3orf23 http://www.ncbi.nlm.nih.gov/gene/285343 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002268 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA C4orf46 http://www.ncbi.nlm.nih.gov/gene/201725 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002269 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA C5orf22 http://www.ncbi.nlm.nih.gov/gene/55322 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002270 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA C6orf162 http://www.ncbi.nlm.nih.gov/gene/57150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002271 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA C8orf37 http://www.ncbi.nlm.nih.gov/gene/157657 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002272 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA C8orf84 http://www.ncbi.nlm.nih.gov/gene/157869 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002273 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA C9orf5 http://www.ncbi.nlm.nih.gov/gene/23731 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002274 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA CAV1 http://www.ncbi.nlm.nih.gov/gene/857 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002275 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA CCDC88A http://www.ncbi.nlm.nih.gov/gene/55704 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002276 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA CDC73 http://www.ncbi.nlm.nih.gov/gene/79577 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002277 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA CEP68 http://www.ncbi.nlm.nih.gov/gene/23177 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002278 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA CHD2 http://www.ncbi.nlm.nih.gov/gene/1106 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002279 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA CHML http://www.ncbi.nlm.nih.gov/gene/1122 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002280 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA CKAP5 http://www.ncbi.nlm.nih.gov/gene/9793 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002281 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA CLDND1 http://www.ncbi.nlm.nih.gov/gene/56650 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002282 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA CLEC2D http://www.ncbi.nlm.nih.gov/gene/29121 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002283 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA CLIC4 http://www.ncbi.nlm.nih.gov/gene/25932 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002284 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA COL4A3BP http://www.ncbi.nlm.nih.gov/gene/10087 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002285 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA COPS8 http://www.ncbi.nlm.nih.gov/gene/10920 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002286 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA CREBL2 http://www.ncbi.nlm.nih.gov/gene/1389 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002287 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA CRYZL1 http://www.ncbi.nlm.nih.gov/gene/9946 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002288 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA CTCF http://www.ncbi.nlm.nih.gov/gene/10664 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002289 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA DCAF7 http://www.ncbi.nlm.nih.gov/gene/10238 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002290 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA DCUN1D1 http://www.ncbi.nlm.nih.gov/gene/54165 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002291 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA DIXDC1 http://www.ncbi.nlm.nih.gov/gene/85458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002292 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA DPY19L4 http://www.ncbi.nlm.nih.gov/gene/286148 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002293 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA DSE http://www.ncbi.nlm.nih.gov/gene/29940 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002294 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA E2F7 http://www.ncbi.nlm.nih.gov/gene/144455 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002295 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ECHDC1 http://www.ncbi.nlm.nih.gov/gene/55862 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002296 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA EDEM3 http://www.ncbi.nlm.nih.gov/gene/80267 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002297 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA EIF1 http://www.ncbi.nlm.nih.gov/gene/730144 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002298 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA EIF2AK3 http://www.ncbi.nlm.nih.gov/gene/9451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002299 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA EIF3L http://www.ncbi.nlm.nih.gov/gene/51386 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002300 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA EIF4G1 http://www.ncbi.nlm.nih.gov/gene/1981 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002301 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ELK4 http://www.ncbi.nlm.nih.gov/gene/2005 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002302 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ERCC6 http://www.ncbi.nlm.nih.gov/gene/2074 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002303 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ETNK1 http://www.ncbi.nlm.nih.gov/gene/55500 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002304 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA EYA1 http://www.ncbi.nlm.nih.gov/gene/2138 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002305 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA EZH2 http://www.ncbi.nlm.nih.gov/gene/2146 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002306 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA FAM8A1 http://www.ncbi.nlm.nih.gov/gene/51439 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002307 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA FAM96A http://www.ncbi.nlm.nih.gov/gene/84191 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002308 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA FBXO30 http://www.ncbi.nlm.nih.gov/gene/84085 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002309 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA FBXO45 http://www.ncbi.nlm.nih.gov/gene/200933 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002310 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA FCHSD2 http://www.ncbi.nlm.nih.gov/gene/9873 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002311 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA FUNDC1 http://www.ncbi.nlm.nih.gov/gene/139341 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002312 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA FUSIP1 http://www.ncbi.nlm.nih.gov/gene/10772 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002313 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA FXC1 http://www.ncbi.nlm.nih.gov/gene/26515 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002314 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA FYN http://www.ncbi.nlm.nih.gov/gene/2534 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002315 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA GAB1 http://www.ncbi.nlm.nih.gov/gene/2549 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002316 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA GORASP2 http://www.ncbi.nlm.nih.gov/gene/26003 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002317 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA GPHN http://www.ncbi.nlm.nih.gov/gene/10243 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002318 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA HACL1 http://www.ncbi.nlm.nih.gov/gene/26061 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002319 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA HECA http://www.ncbi.nlm.nih.gov/gene/51696 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002320 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ILF2 http://www.ncbi.nlm.nih.gov/gene/3608 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002321 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA IMPA1 http://www.ncbi.nlm.nih.gov/gene/3612 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002322 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA IMPAD1 http://www.ncbi.nlm.nih.gov/gene/54928 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002323 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ITSN1 http://www.ncbi.nlm.nih.gov/gene/6453 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002324 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA KAT2B http://www.ncbi.nlm.nih.gov/gene/8850 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002325 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA KIAA1432 http://www.ncbi.nlm.nih.gov/gene/57589 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002326 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA KIAA1967 http://www.ncbi.nlm.nih.gov/gene/57805 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002327 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA KIF5B http://www.ncbi.nlm.nih.gov/gene/3799 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002328 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA KPNA1 http://www.ncbi.nlm.nih.gov/gene/3836 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002329 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA LIN28B http://www.ncbi.nlm.nih.gov/gene/389421 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002330 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA LRP1 http://www.ncbi.nlm.nih.gov/gene/4035 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002331 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA LRRC8B http://www.ncbi.nlm.nih.gov/gene/23507 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002332 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA LSM14A http://www.ncbi.nlm.nih.gov/gene/26065 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002333 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA MAN1A2 http://www.ncbi.nlm.nih.gov/gene/10905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002334 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA MBNL2 http://www.ncbi.nlm.nih.gov/gene/10150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002335 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA MCFD2 http://www.ncbi.nlm.nih.gov/gene/90411 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002336 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA MCM2 http://www.ncbi.nlm.nih.gov/gene/4171 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002337 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA MEX3C http://www.ncbi.nlm.nih.gov/gene/51320 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002338 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA MITF http://www.ncbi.nlm.nih.gov/gene/4286 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002339 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA MOBKL3 http://www.ncbi.nlm.nih.gov/gene/25843 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002340 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA MORC3 http://www.ncbi.nlm.nih.gov/gene/23515 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002341 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA MOSPD2 http://www.ncbi.nlm.nih.gov/gene/158747 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002342 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA MRPS31 http://www.ncbi.nlm.nih.gov/gene/10240 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002343 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA MSL2 http://www.ncbi.nlm.nih.gov/gene/55167 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002344 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA MTMR14 http://www.ncbi.nlm.nih.gov/gene/64419 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002345 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA MTPN http://www.ncbi.nlm.nih.gov/gene/767558 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002346 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA NETO2 http://www.ncbi.nlm.nih.gov/gene/81831 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002347 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA NFIA http://www.ncbi.nlm.nih.gov/gene/4774 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002348 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA NHLRC3 http://www.ncbi.nlm.nih.gov/gene/387921 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002349 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA NOTCH2 http://www.ncbi.nlm.nih.gov/gene/4853 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002350 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA NUB1 http://www.ncbi.nlm.nih.gov/gene/51667 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002351 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA OBFC2A http://www.ncbi.nlm.nih.gov/gene/64859 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002352 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA OGT http://www.ncbi.nlm.nih.gov/gene/8473 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002353 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA OSBP http://www.ncbi.nlm.nih.gov/gene/5007 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002354 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA OSTC http://www.ncbi.nlm.nih.gov/gene/646567 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002355 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA OTUD6B http://www.ncbi.nlm.nih.gov/gene/51633 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002356 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA OTUD7B http://www.ncbi.nlm.nih.gov/gene/56957 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002357 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA PACRGL http://www.ncbi.nlm.nih.gov/gene/133015 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002358 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA PALM2-AKAP2 http://www.ncbi.nlm.nih.gov/gene/114299 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002359 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA PANK3 http://www.ncbi.nlm.nih.gov/gene/79646 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002360 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA PCGF3 http://www.ncbi.nlm.nih.gov/gene/10336 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002361 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA PCMTD2 http://www.ncbi.nlm.nih.gov/gene/55251 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002362 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA PCTK1 http://www.ncbi.nlm.nih.gov/gene/5127 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002363 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA PDPR http://www.ncbi.nlm.nih.gov/gene/55066 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002364 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA PK4P # - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002365 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA PLEKHF2 http://www.ncbi.nlm.nih.gov/gene/79666 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002366 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA POT1 http://www.ncbi.nlm.nih.gov/gene/25913 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002367 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA POU2F1 http://www.ncbi.nlm.nih.gov/gene/5451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002368 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA PPAP2B http://www.ncbi.nlm.nih.gov/gene/8613 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002369 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA PPT1 http://www.ncbi.nlm.nih.gov/gene/5538 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002370 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA PRKAB2 http://www.ncbi.nlm.nih.gov/gene/5565 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002371 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA PRPSAP2 http://www.ncbi.nlm.nih.gov/gene/5636 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002372 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA PSMD12 http://www.ncbi.nlm.nih.gov/gene/5718 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002373 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA PSME4 http://www.ncbi.nlm.nih.gov/gene/23198 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002374 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA PSTK http://www.ncbi.nlm.nih.gov/gene/118672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002375 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA PTEN http://www.ncbi.nlm.nih.gov/gene/11191 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002376 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA PURA http://www.ncbi.nlm.nih.gov/gene/5813 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002377 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA QKI http://www.ncbi.nlm.nih.gov/gene/9444 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002378 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA RAB14 http://www.ncbi.nlm.nih.gov/gene/51552 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002379 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA RAB3GAP2 http://www.ncbi.nlm.nih.gov/gene/25782 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002380 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA RC3H1 http://www.ncbi.nlm.nih.gov/gene/149041 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002381 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA RELL1 http://www.ncbi.nlm.nih.gov/gene/768211 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002382 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA RERE http://www.ncbi.nlm.nih.gov/gene/473 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002383 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA RHOU http://www.ncbi.nlm.nih.gov/gene/58480 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002384 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA RNF111 http://www.ncbi.nlm.nih.gov/gene/54778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002385 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA RNF160 http://www.ncbi.nlm.nih.gov/gene/26046 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002386 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA RORA http://www.ncbi.nlm.nih.gov/gene/6095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002387 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA RRM2B http://www.ncbi.nlm.nih.gov/gene/50484 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002388 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA SETD5 http://www.ncbi.nlm.nih.gov/gene/55209 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002389 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA SLC16A14 http://www.ncbi.nlm.nih.gov/gene/151473 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002390 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA SLC30A7 http://www.ncbi.nlm.nih.gov/gene/148867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002391 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA SLC38A1 http://www.ncbi.nlm.nih.gov/gene/81539 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002392 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA SLC9A6 http://www.ncbi.nlm.nih.gov/gene/10479 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002393 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA SLMO2 http://www.ncbi.nlm.nih.gov/gene/51012 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002394 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA SMEK1 http://www.ncbi.nlm.nih.gov/gene/55671 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002395 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA SPRED1 http://www.ncbi.nlm.nih.gov/gene/161742 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002396 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA SSFA2 http://www.ncbi.nlm.nih.gov/gene/6744 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002397 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA STAM http://www.ncbi.nlm.nih.gov/gene/8027 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002398 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA STAT1 http://www.ncbi.nlm.nih.gov/gene/6772 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002399 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA TANC1 http://www.ncbi.nlm.nih.gov/gene/85461 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002400 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA TANC2 http://www.ncbi.nlm.nih.gov/gene/26115 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002401 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA TBC1D25 http://www.ncbi.nlm.nih.gov/gene/4943 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002402 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA TMCC1 http://www.ncbi.nlm.nih.gov/gene/23023 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002403 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA TMEM135 http://www.ncbi.nlm.nih.gov/gene/65084 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002404 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA TMEM20 http://www.ncbi.nlm.nih.gov/gene/159371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002405 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA TMEM64 http://www.ncbi.nlm.nih.gov/gene/169200 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002406 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA TP53INP1 http://www.ncbi.nlm.nih.gov/gene/94241 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002407 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA TPM4 http://www.ncbi.nlm.nih.gov/gene/7171 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002408 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA TRA2B http://www.ncbi.nlm.nih.gov/gene/6434 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002409 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA TRAK2 http://www.ncbi.nlm.nih.gov/gene/66008 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002410 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA TRIAP1 http://www.ncbi.nlm.nih.gov/gene/51499 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002411 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA TRIM38 http://www.ncbi.nlm.nih.gov/gene/10475 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002412 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA TRIM4 http://www.ncbi.nlm.nih.gov/gene/89122 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002413 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA TRUB1 http://www.ncbi.nlm.nih.gov/gene/142940 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002414 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA TUSC2 http://www.ncbi.nlm.nih.gov/gene/11334 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002415 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA UBE2R2 http://www.ncbi.nlm.nih.gov/gene/54926 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002416 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA UBE2W http://www.ncbi.nlm.nih.gov/gene/55284 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002417 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA UBTD2 http://www.ncbi.nlm.nih.gov/gene/92181 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002418 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA UBXN4 http://www.ncbi.nlm.nih.gov/gene/23190 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002419 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA UCHL3 http://www.ncbi.nlm.nih.gov/gene/7347 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002420 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA USP28 http://www.ncbi.nlm.nih.gov/gene/57646 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002421 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA USP3 http://www.ncbi.nlm.nih.gov/gene/9960 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002422 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA VANGL1 http://www.ncbi.nlm.nih.gov/gene/81839 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002423 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA WASL http://www.ncbi.nlm.nih.gov/gene/8976 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002424 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA WDR33 http://www.ncbi.nlm.nih.gov/gene/55339 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002425 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA WDR48 http://www.ncbi.nlm.nih.gov/gene/57599 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002426 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA XIAP http://www.ncbi.nlm.nih.gov/gene/331 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002427 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA XPO1 http://www.ncbi.nlm.nih.gov/gene/7514 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002428 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA YIPF6 http://www.ncbi.nlm.nih.gov/gene/286451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002429 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ZCCHC3 http://www.ncbi.nlm.nih.gov/gene/85364 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002430 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ZFAND6 http://www.ncbi.nlm.nih.gov/gene/54469 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002431 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ZFR http://www.ncbi.nlm.nih.gov/gene/51663 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002432 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ZKSCAN1 http://www.ncbi.nlm.nih.gov/gene/7586 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002433 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ZNF146 http://www.ncbi.nlm.nih.gov/gene/7705 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002434 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ZNF202 http://www.ncbi.nlm.nih.gov/gene/7753 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002435 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ZNF28 http://www.ncbi.nlm.nih.gov/gene/7576 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002436 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ZNF295 http://www.ncbi.nlm.nih.gov/gene/49854 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002437 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ZNF33B http://www.ncbi.nlm.nih.gov/gene/7582 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002438 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-3p(ebv-mir-bart21-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010131 BC-1 - Host mRNA ZNF548 http://www.ncbi.nlm.nih.gov/gene/147694 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002439 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA SEPT2 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002440 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA MARCH7 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002441 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA ACBD3 http://www.ncbi.nlm.nih.gov/gene/64746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002442 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA AEBP2 http://www.ncbi.nlm.nih.gov/gene/121536 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002443 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA ARL4A http://www.ncbi.nlm.nih.gov/gene/10124 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002444 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA C14orf28 http://www.ncbi.nlm.nih.gov/gene/122525 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002445 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA C16orf88 http://www.ncbi.nlm.nih.gov/gene/400506 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002446 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA C5orf51 http://www.ncbi.nlm.nih.gov/gene/285636 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002447 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA CAPZA1 http://www.ncbi.nlm.nih.gov/gene/829 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002448 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA CBX3 http://www.ncbi.nlm.nih.gov/gene/11335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002449 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA CHD2 http://www.ncbi.nlm.nih.gov/gene/1106 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002450 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA DAZAP2 http://www.ncbi.nlm.nih.gov/gene/9802 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002451 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA FAM126A http://www.ncbi.nlm.nih.gov/gene/84668 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002452 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA FAM46C http://www.ncbi.nlm.nih.gov/gene/54855 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002453 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA FBXO21 http://www.ncbi.nlm.nih.gov/gene/23014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002454 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA FXR1 http://www.ncbi.nlm.nih.gov/gene/8087 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002455 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA GTF2B http://www.ncbi.nlm.nih.gov/gene/2959 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002456 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA HECTD1 http://www.ncbi.nlm.nih.gov/gene/25831 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002457 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA HNRNPU http://www.ncbi.nlm.nih.gov/gene/3192 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002458 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA INO80D http://www.ncbi.nlm.nih.gov/gene/54891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002459 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA MTRR http://www.ncbi.nlm.nih.gov/gene/4552 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002460 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA NAT13 http://www.ncbi.nlm.nih.gov/gene/80218 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002461 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA NSL1 http://www.ncbi.nlm.nih.gov/gene/25936 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002462 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA NUP35 http://www.ncbi.nlm.nih.gov/gene/129401 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002463 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA OTUD4 http://www.ncbi.nlm.nih.gov/gene/54726 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002464 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA PGRMC1 http://www.ncbi.nlm.nih.gov/gene/10857 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002465 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA PLAG1 http://www.ncbi.nlm.nih.gov/gene/5324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002466 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA PLIN http://www.ncbi.nlm.nih.gov/gene/5346 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002467 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA RAB10 http://www.ncbi.nlm.nih.gov/gene/10890 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002468 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA RIT1 http://www.ncbi.nlm.nih.gov/gene/6016 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002469 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA SLAIN2 http://www.ncbi.nlm.nih.gov/gene/57606 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002470 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA SLC19A2 http://www.ncbi.nlm.nih.gov/gene/10560 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002471 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA SLC30A6 http://www.ncbi.nlm.nih.gov/gene/55676 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002472 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA SOCS4 http://www.ncbi.nlm.nih.gov/gene/122809 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002473 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA THOC7 http://www.ncbi.nlm.nih.gov/gene/80145 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002474 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA WDR1 http://www.ncbi.nlm.nih.gov/gene/9948 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002475 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA WNK1 http://www.ncbi.nlm.nih.gov/gene/65125 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002476 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA ZNF225 http://www.ncbi.nlm.nih.gov/gene/7768 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002477 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA ZNF295 http://www.ncbi.nlm.nih.gov/gene/49854 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002478 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA ZNF317 http://www.ncbi.nlm.nih.gov/gene/57693 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002479 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART21-5p(ebv-mir-bart21-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010130 BC-1 - Host mRNA ZNF680 http://www.ncbi.nlm.nih.gov/gene/340252 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002480 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA BNC2 http://www.ncbi.nlm.nih.gov/gene/54796 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002481 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA CLCC1 http://www.ncbi.nlm.nih.gov/gene/23155 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002482 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA CPEB2 http://www.ncbi.nlm.nih.gov/gene/132864 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002483 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA DSTYK http://www.ncbi.nlm.nih.gov/gene/25778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002484 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA EEF1A1 http://www.ncbi.nlm.nih.gov/gene/441032 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002485 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA ETHE1 http://www.ncbi.nlm.nih.gov/gene/23474 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002486 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA FRRS1 http://www.ncbi.nlm.nih.gov/gene/391059 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002487 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA GALNT10 http://www.ncbi.nlm.nih.gov/gene/55568 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002488 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA GPSM2 http://www.ncbi.nlm.nih.gov/gene/29899 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002489 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA HADHB http://www.ncbi.nlm.nih.gov/gene/3032 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002490 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA IGF1R http://www.ncbi.nlm.nih.gov/gene/3480 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002491 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA ITGA5 http://www.ncbi.nlm.nih.gov/gene/3678 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002492 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA KBTBD8 http://www.ncbi.nlm.nih.gov/gene/84541 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002493 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA LCOR http://www.ncbi.nlm.nih.gov/gene/84458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002494 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA LMBR1 http://www.ncbi.nlm.nih.gov/gene/64327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002495 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA MMD http://www.ncbi.nlm.nih.gov/gene/23531 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002496 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA MTMR1 http://www.ncbi.nlm.nih.gov/gene/8776 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002497 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA NFATC3 http://www.ncbi.nlm.nih.gov/gene/4775 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002498 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA NFYC http://www.ncbi.nlm.nih.gov/gene/4802 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002499 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA RAB5A http://www.ncbi.nlm.nih.gov/gene/5868 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002500 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA RNF157 http://www.ncbi.nlm.nih.gov/gene/114804 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002501 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA RORA http://www.ncbi.nlm.nih.gov/gene/6095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002502 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA SLC37A3 http://www.ncbi.nlm.nih.gov/gene/84255 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002503 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA TRIB1 http://www.ncbi.nlm.nih.gov/gene/10221 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002504 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA TROVE2 http://www.ncbi.nlm.nih.gov/gene/6738 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002505 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA UBN2 http://www.ncbi.nlm.nih.gov/gene/254048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002506 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA VHL http://www.ncbi.nlm.nih.gov/gene/7428 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002507 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA WDR43 http://www.ncbi.nlm.nih.gov/gene/23160 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002508 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA ZFAND5 http://www.ncbi.nlm.nih.gov/gene/732229 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002509 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 BC-1 - Host mRNA ZKSCAN1 http://www.ncbi.nlm.nih.gov/gene/7586 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002510 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 Lymphoblastoid cell lines - Host mRNA BARD1 http://www.ncbi.nlm.nih.gov/gene/580 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00002511 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 Lymphoblastoid cell lines - Host mRNA EEF1A1 http://www.ncbi.nlm.nih.gov/gene/441032 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00002512 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 Lymphoblastoid cell lines - Host mRNA ETHE1 http://www.ncbi.nlm.nih.gov/gene/23474 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00002513 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 Lymphoblastoid cell lines - Host mRNA FRRS1 http://www.ncbi.nlm.nih.gov/gene/391059 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00002514 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 Lymphoblastoid cell lines - Host mRNA HADHB http://www.ncbi.nlm.nih.gov/gene/3032 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00002515 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 Lymphoblastoid cell lines - Host mRNA MMD http://www.ncbi.nlm.nih.gov/gene/23531 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00002516 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 Lymphoblastoid cell lines - Host mRNA TROVE2 http://www.ncbi.nlm.nih.gov/gene/6738 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00002517 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(ebv-mir-bart3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 Lymphoblastoid cell lines - Host mRNA ZFAND5 http://www.ncbi.nlm.nih.gov/gene/732229 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00002518 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA AAK1 http://www.ncbi.nlm.nih.gov/gene/22848 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002519 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA ADPGK http://www.ncbi.nlm.nih.gov/gene/83440 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002520 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA ARFGEF2 http://www.ncbi.nlm.nih.gov/gene/10564 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002521 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA BCL2L11 http://www.ncbi.nlm.nih.gov/gene/10018 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002522 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA BRMS1L http://www.ncbi.nlm.nih.gov/gene/84312 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002523 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA C1orf55 http://www.ncbi.nlm.nih.gov/gene/163859 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002524 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA CDV3 http://www.ncbi.nlm.nih.gov/gene/55573 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002525 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA COMMD10 http://www.ncbi.nlm.nih.gov/gene/51397 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002526 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA CPT2 http://www.ncbi.nlm.nih.gov/gene/1376 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002527 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA DHX40 http://www.ncbi.nlm.nih.gov/gene/100134387 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002528 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA E2F3 http://www.ncbi.nlm.nih.gov/gene/1871 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002529 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA ERCC6 http://www.ncbi.nlm.nih.gov/gene/2074 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002530 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA FLJ40142 http://www.ncbi.nlm.nih.gov/gene/400073 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002531 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA FNBP4 http://www.ncbi.nlm.nih.gov/gene/23360 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002532 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA HBP1 http://www.ncbi.nlm.nih.gov/gene/26959 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002533 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA KIAA1826 http://www.ncbi.nlm.nih.gov/gene/84437 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002534 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA MIB1 http://www.ncbi.nlm.nih.gov/gene/57534 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002535 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA PANK3 http://www.ncbi.nlm.nih.gov/gene/79646 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002536 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA POU2AF1 http://www.ncbi.nlm.nih.gov/gene/5450 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002537 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA RCOR1 http://www.ncbi.nlm.nih.gov/gene/23186 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002538 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA RNF160 http://www.ncbi.nlm.nih.gov/gene/26046 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002539 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA SLC7A1 http://www.ncbi.nlm.nih.gov/gene/6541 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002540 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA SMC2 http://www.ncbi.nlm.nih.gov/gene/10592 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002541 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA SMNDC1 http://www.ncbi.nlm.nih.gov/gene/10285 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002542 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA SOX12 http://www.ncbi.nlm.nih.gov/gene/6666 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002543 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA TUBGCP3 http://www.ncbi.nlm.nih.gov/gene/10426 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002544 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Jijoye cells - Host mRNA ZBED4 http://www.ncbi.nlm.nih.gov/gene/9889 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002545 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4-3p(ebv-mir-bart4*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009204 Lymphoblastoid cell lines - Host mRNA CLEC7A http://www.ncbi.nlm.nih.gov/gene/64581 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00002546 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4-3p(ebv-mir-bart4*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009204 Lymphoblastoid cell lines - Host mRNA CPSF7 http://www.ncbi.nlm.nih.gov/gene/79869 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00002547 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4-3p(ebv-mir-bart4*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009204 Lymphoblastoid cell lines - Host mRNA ELOF1 http://www.ncbi.nlm.nih.gov/gene/84337 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00002548 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4-3p(ebv-mir-bart4*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009204 Lymphoblastoid cell lines - Host mRNA FAM126B http://www.ncbi.nlm.nih.gov/gene/285172 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00002549 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4-3p(ebv-mir-bart4*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009204 Lymphoblastoid cell lines - Host mRNA GLO1 http://www.ncbi.nlm.nih.gov/gene/2739 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00002550 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4-3p(ebv-mir-bart4*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009204 Lymphoblastoid cell lines - Host mRNA HMGCS1 http://www.ncbi.nlm.nih.gov/gene/3157 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00002551 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4-3p(ebv-mir-bart4*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009204 Lymphoblastoid cell lines - Host mRNA IRF4 http://www.ncbi.nlm.nih.gov/gene/3662 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00002552 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4-3p(ebv-mir-bart4*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009204 Lymphoblastoid cell lines - Host mRNA NFE2L2 http://www.ncbi.nlm.nih.gov/gene/4780 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00002553 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART4-3p(ebv-mir-bart4*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009204 Lymphoblastoid cell lines - Host mRNA WDR33 http://www.ncbi.nlm.nih.gov/gene/55339 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00002554 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA ABL2 http://www.ncbi.nlm.nih.gov/gene/27 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002555 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA AKT1S1 http://www.ncbi.nlm.nih.gov/gene/84335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002556 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA ARID1A http://www.ncbi.nlm.nih.gov/gene/8289 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002557 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA BRE http://www.ncbi.nlm.nih.gov/gene/9577 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002558 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA BRWD1 http://www.ncbi.nlm.nih.gov/gene/54014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002559 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA C17orf63 http://www.ncbi.nlm.nih.gov/gene/55731 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002560 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA C1orf144 http://www.ncbi.nlm.nih.gov/gene/26099 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002561 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA C20orf112 http://www.ncbi.nlm.nih.gov/gene/140688 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002562 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA C4orf46 http://www.ncbi.nlm.nih.gov/gene/201725 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002563 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA CBARA1 http://www.ncbi.nlm.nih.gov/gene/10367 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002564 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA CCND2 http://www.ncbi.nlm.nih.gov/gene/894 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002565 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA CDC2L6 http://www.ncbi.nlm.nih.gov/gene/23097 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002566 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA CFL1 http://www.ncbi.nlm.nih.gov/gene/1072 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002567 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA CLOCK http://www.ncbi.nlm.nih.gov/gene/9575 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002568 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA CYTH2 http://www.ncbi.nlm.nih.gov/gene/9266 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002569 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA DCLRE1C http://www.ncbi.nlm.nih.gov/gene/64421 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002570 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA DOLPP1 http://www.ncbi.nlm.nih.gov/gene/57171 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002571 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA DUSP18 http://www.ncbi.nlm.nih.gov/gene/150290 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002572 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA DYRK2 http://www.ncbi.nlm.nih.gov/gene/8445 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002573 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA FNDC3A http://www.ncbi.nlm.nih.gov/gene/22862 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002574 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA GNAI2 http://www.ncbi.nlm.nih.gov/gene/2771 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002575 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA GTPBP10 http://www.ncbi.nlm.nih.gov/gene/85865 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002576 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA HMG20A http://www.ncbi.nlm.nih.gov/gene/10363 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002577 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA ITPKB http://www.ncbi.nlm.nih.gov/gene/3707 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002578 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA LZIC http://www.ncbi.nlm.nih.gov/gene/84328 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002579 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA MKNK2 http://www.ncbi.nlm.nih.gov/gene/2872 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002580 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA MPV17 http://www.ncbi.nlm.nih.gov/gene/4358 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002581 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA OTUD7B http://www.ncbi.nlm.nih.gov/gene/56957 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002582 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA PRDM1 http://www.ncbi.nlm.nih.gov/gene/639 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002583 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA PRMT6 http://www.ncbi.nlm.nih.gov/gene/55170 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002584 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA PXT1 http://www.ncbi.nlm.nih.gov/gene/222659 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002585 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA RBAK http://www.ncbi.nlm.nih.gov/gene/389458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002586 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA RBM15B http://www.ncbi.nlm.nih.gov/gene/29890 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002587 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA RPS6KA1 http://www.ncbi.nlm.nih.gov/gene/6195 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002588 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA SENP1 http://www.ncbi.nlm.nih.gov/gene/29843 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002589 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA SHC1 http://www.ncbi.nlm.nih.gov/gene/6464 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002590 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA SNTB1 http://www.ncbi.nlm.nih.gov/gene/6641 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002591 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA TFPI http://www.ncbi.nlm.nih.gov/gene/7035 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002592 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA TNFRSF10B http://www.ncbi.nlm.nih.gov/gene/8795 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002593 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA TOMM20 http://www.ncbi.nlm.nih.gov/gene/100129272 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002594 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA TOMM22 http://www.ncbi.nlm.nih.gov/gene/56993 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002595 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA TRIB1 http://www.ncbi.nlm.nih.gov/gene/10221 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002596 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA TSC1 http://www.ncbi.nlm.nih.gov/gene/7248 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002597 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA UBA1 http://www.ncbi.nlm.nih.gov/gene/7317 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002598 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA WDR32 http://www.ncbi.nlm.nih.gov/gene/79269 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002599 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA WWTR1 http://www.ncbi.nlm.nih.gov/gene/25937 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002600 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA YARS http://www.ncbi.nlm.nih.gov/gene/8565 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002601 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-3p(ebv-mir-bart6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003415 BC-1 - Host mRNA YIPF6 http://www.ncbi.nlm.nih.gov/gene/286451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002602 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(BART-6-5P) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 - - Host Protein DICER1 http://www.ncbi.nlm.nih.gov/gene/23405 - PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets (Table 1).Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV- and EBV-encoded miRNAs. VHID00002603 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA AAGAB http://www.ncbi.nlm.nih.gov/gene/79719 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002604 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ACOX3 http://www.ncbi.nlm.nih.gov/gene/8310 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002605 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ANKRD46 http://www.ncbi.nlm.nih.gov/gene/157567 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002606 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ANXA7 http://www.ncbi.nlm.nih.gov/gene/310 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002607 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA APLP2 http://www.ncbi.nlm.nih.gov/gene/334 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002608 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ARL2 http://www.ncbi.nlm.nih.gov/gene/402 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002609 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ARL5B http://www.ncbi.nlm.nih.gov/gene/221079 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002610 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ARPP19 http://www.ncbi.nlm.nih.gov/gene/646227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002611 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ATXN3 http://www.ncbi.nlm.nih.gov/gene/4287 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002612 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA AVL9 http://www.ncbi.nlm.nih.gov/gene/23080 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002613 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA BBX http://www.ncbi.nlm.nih.gov/gene/56987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002614 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA BNIP3L http://www.ncbi.nlm.nih.gov/gene/665 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002615 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA BRPF3 http://www.ncbi.nlm.nih.gov/gene/27154 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002616 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA BTG3 http://www.ncbi.nlm.nih.gov/gene/10950 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002617 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA C15orf23 http://www.ncbi.nlm.nih.gov/gene/90417 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002618 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA C18orf54 http://www.ncbi.nlm.nih.gov/gene/162681 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002619 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA C19orf12 http://www.ncbi.nlm.nih.gov/gene/83636 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002620 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA C1orf107 http://www.ncbi.nlm.nih.gov/gene/27042 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002621 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA C6orf120 http://www.ncbi.nlm.nih.gov/gene/387263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002622 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA C7orf43 http://www.ncbi.nlm.nih.gov/gene/55262 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002623 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA CALM2 http://www.ncbi.nlm.nih.gov/gene/808 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002624 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA CALU http://www.ncbi.nlm.nih.gov/gene/813 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002625 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA CAMSAP1L1 http://www.ncbi.nlm.nih.gov/gene/23271 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002626 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA CBFB http://www.ncbi.nlm.nih.gov/gene/865 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002627 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA CCDC47 http://www.ncbi.nlm.nih.gov/gene/57003 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002628 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA CCNG1 http://www.ncbi.nlm.nih.gov/gene/900 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002629 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA CCNJ http://www.ncbi.nlm.nih.gov/gene/54619 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002630 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002631 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA CDC2L5 http://www.ncbi.nlm.nih.gov/gene/8621 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002632 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA CDV3 http://www.ncbi.nlm.nih.gov/gene/55573 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002633 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA CLTC http://www.ncbi.nlm.nih.gov/gene/1213 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002634 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA CPEB2 http://www.ncbi.nlm.nih.gov/gene/132864 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002635 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA CTDSPL2 http://www.ncbi.nlm.nih.gov/gene/51496 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002636 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA DCK http://www.ncbi.nlm.nih.gov/gene/1633 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002637 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA DCTN4 http://www.ncbi.nlm.nih.gov/gene/51164 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002638 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA DIDO1 http://www.ncbi.nlm.nih.gov/gene/11083 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002639 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA DNAJB9 http://www.ncbi.nlm.nih.gov/gene/4189 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002640 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA DOT1L http://www.ncbi.nlm.nih.gov/gene/84444 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002641 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA EEA1 http://www.ncbi.nlm.nih.gov/gene/8411 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002642 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA EIF1AD http://www.ncbi.nlm.nih.gov/gene/84285 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002643 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA EIF4B http://www.ncbi.nlm.nih.gov/gene/1975 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002644 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ELK4 http://www.ncbi.nlm.nih.gov/gene/2005 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002645 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA EMP3 http://www.ncbi.nlm.nih.gov/gene/2014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002646 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ERLIN1 http://www.ncbi.nlm.nih.gov/gene/10613 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002647 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA FAM108C1 http://www.ncbi.nlm.nih.gov/gene/58489 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002648 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA FAM134A http://www.ncbi.nlm.nih.gov/gene/79137 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002649 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA FAM174A http://www.ncbi.nlm.nih.gov/gene/345757 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002650 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA FAM36A http://www.ncbi.nlm.nih.gov/gene/116228 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002651 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA FAM46C http://www.ncbi.nlm.nih.gov/gene/54855 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002652 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA FAM98B http://www.ncbi.nlm.nih.gov/gene/283742 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002653 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA FASTKD2 http://www.ncbi.nlm.nih.gov/gene/22868 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002654 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA FBXO3 http://www.ncbi.nlm.nih.gov/gene/26273 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002655 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA FBXO45 http://www.ncbi.nlm.nih.gov/gene/200933 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002656 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA FUSIP1 http://www.ncbi.nlm.nih.gov/gene/10772 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002657 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA FZD3 http://www.ncbi.nlm.nih.gov/gene/7976 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002658 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA G3BP2 http://www.ncbi.nlm.nih.gov/gene/9908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002659 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA GABPB1 http://www.ncbi.nlm.nih.gov/gene/2553 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002660 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA GBP3 http://www.ncbi.nlm.nih.gov/gene/2635 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002661 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA GNAQ http://www.ncbi.nlm.nih.gov/gene/2776 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002662 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA GPATCH8 http://www.ncbi.nlm.nih.gov/gene/23131 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002663 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA GPRIN3 http://www.ncbi.nlm.nih.gov/gene/285513 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002664 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA HAT1 http://www.ncbi.nlm.nih.gov/gene/8520 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002665 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA HCFC2 http://www.ncbi.nlm.nih.gov/gene/29915 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002666 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA HDHD3 http://www.ncbi.nlm.nih.gov/gene/81932 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002667 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA HMGXB4 http://www.ncbi.nlm.nih.gov/gene/10042 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002668 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA HN1 http://www.ncbi.nlm.nih.gov/gene/51155 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002669 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA HSPH1 http://www.ncbi.nlm.nih.gov/gene/10808 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002670 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ICK http://www.ncbi.nlm.nih.gov/gene/22858 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002671 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ICMT http://www.ncbi.nlm.nih.gov/gene/23463 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002672 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ICT1 http://www.ncbi.nlm.nih.gov/gene/3396 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002673 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA IDE http://www.ncbi.nlm.nih.gov/gene/3416 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002674 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA IFIH1 http://www.ncbi.nlm.nih.gov/gene/64135 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002675 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA IRS1 http://www.ncbi.nlm.nih.gov/gene/3667 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002676 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ITGAV http://www.ncbi.nlm.nih.gov/gene/3685 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002677 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA KBTBD6 http://www.ncbi.nlm.nih.gov/gene/89890 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002678 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA KDM2A http://www.ncbi.nlm.nih.gov/gene/22992 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002679 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA KIAA0776 http://www.ncbi.nlm.nih.gov/gene/23376 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002680 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA KIAA1432 http://www.ncbi.nlm.nih.gov/gene/57589 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002681 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA KLF12 http://www.ncbi.nlm.nih.gov/gene/11278 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002682 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA KLHL9 http://www.ncbi.nlm.nih.gov/gene/55958 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002683 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA LARP4B http://www.ncbi.nlm.nih.gov/gene/23185 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002684 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA LCOR http://www.ncbi.nlm.nih.gov/gene/84458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002685 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA LEPROTL1 http://www.ncbi.nlm.nih.gov/gene/23484 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002686 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA MANEA http://www.ncbi.nlm.nih.gov/gene/79694 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002687 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA MFAP3 http://www.ncbi.nlm.nih.gov/gene/4238 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002688 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA MIER3 http://www.ncbi.nlm.nih.gov/gene/166968 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002689 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA MLL http://www.ncbi.nlm.nih.gov/gene/4297 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002690 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA MLLT10 http://www.ncbi.nlm.nih.gov/gene/8028 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002691 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA MLLT3 http://www.ncbi.nlm.nih.gov/gene/4300 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002692 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA MPP6 http://www.ncbi.nlm.nih.gov/gene/51678 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002693 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA MTHFD2L http://www.ncbi.nlm.nih.gov/gene/441024 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002694 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA MTRR http://www.ncbi.nlm.nih.gov/gene/4552 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002695 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA MYC http://www.ncbi.nlm.nih.gov/gene/4609 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002696 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA NAPEPLD http://www.ncbi.nlm.nih.gov/gene/222236 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002697 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA NEK7 http://www.ncbi.nlm.nih.gov/gene/140609 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002698 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA NHLRC2 http://www.ncbi.nlm.nih.gov/gene/374354 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002699 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA NIPSNAP3A http://www.ncbi.nlm.nih.gov/gene/25934 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002700 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA NPTN http://www.ncbi.nlm.nih.gov/gene/27020 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002701 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA NT5DC3 http://www.ncbi.nlm.nih.gov/gene/51559 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002702 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA NUCKS1 http://www.ncbi.nlm.nih.gov/gene/64710 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002703 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA NUPL1 http://www.ncbi.nlm.nih.gov/gene/9818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002704 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA OTUD1 http://www.ncbi.nlm.nih.gov/gene/220213 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002705 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA PA2G4 http://www.ncbi.nlm.nih.gov/gene/5036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002706 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA PCGF3 http://www.ncbi.nlm.nih.gov/gene/10336 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002707 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA PDPR http://www.ncbi.nlm.nih.gov/gene/55066 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002708 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA PHF14 http://www.ncbi.nlm.nih.gov/gene/9678 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002709 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA PIM2 http://www.ncbi.nlm.nih.gov/gene/11040 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002710 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA PK4P # - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002711 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA PLEKHB2 http://www.ncbi.nlm.nih.gov/gene/55041 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002712 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA PLEKHF2 http://www.ncbi.nlm.nih.gov/gene/79666 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002713 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA POU2F1 http://www.ncbi.nlm.nih.gov/gene/5451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002714 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA PRDM2 http://www.ncbi.nlm.nih.gov/gene/7799 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002715 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA PRKACB http://www.ncbi.nlm.nih.gov/gene/5567 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002716 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA PSMC2 http://www.ncbi.nlm.nih.gov/gene/5701 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002717 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA PTP4A1 http://www.ncbi.nlm.nih.gov/gene/7803 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002718 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA PXMP3 http://www.ncbi.nlm.nih.gov/gene/5828 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002719 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA RAD51 http://www.ncbi.nlm.nih.gov/gene/5888 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002720 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA RAG1 http://www.ncbi.nlm.nih.gov/gene/5896 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002721 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA REST http://www.ncbi.nlm.nih.gov/gene/5978 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002722 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA RHOBTB3 http://www.ncbi.nlm.nih.gov/gene/22836 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002723 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ROCK2 http://www.ncbi.nlm.nih.gov/gene/9475 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002724 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA RPL30 http://www.ncbi.nlm.nih.gov/gene/6156 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002725 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA RPRD1B http://www.ncbi.nlm.nih.gov/gene/58490 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002726 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA SACS http://www.ncbi.nlm.nih.gov/gene/26278 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002727 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA SC4MOL http://www.ncbi.nlm.nih.gov/gene/6307 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002728 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA SCFD1 http://www.ncbi.nlm.nih.gov/gene/23256 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002729 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA SEMA3D http://www.ncbi.nlm.nih.gov/gene/223117 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002730 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA SENP2 http://www.ncbi.nlm.nih.gov/gene/59343 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002731 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA SERP1 http://www.ncbi.nlm.nih.gov/gene/27230 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002732 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA SET http://www.ncbi.nlm.nih.gov/gene/646817 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002733 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA SFRS7 http://www.ncbi.nlm.nih.gov/gene/6432 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002734 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA SKI http://www.ncbi.nlm.nih.gov/gene/6497 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002735 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA SKP1 http://www.ncbi.nlm.nih.gov/gene/6500 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002736 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA SLC19A2 http://www.ncbi.nlm.nih.gov/gene/10560 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002737 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA SLC35B4 http://www.ncbi.nlm.nih.gov/gene/84912 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002738 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA SLC41A1 http://www.ncbi.nlm.nih.gov/gene/254428 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002739 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA SMC5 http://www.ncbi.nlm.nih.gov/gene/23137 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002740 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA SMG1 http://www.ncbi.nlm.nih.gov/gene/23049 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002741 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA SNX10 http://www.ncbi.nlm.nih.gov/gene/29887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002742 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA SNX13 http://www.ncbi.nlm.nih.gov/gene/23161 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002743 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA SNX18 http://www.ncbi.nlm.nih.gov/gene/112574 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002744 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA SOCS5 http://www.ncbi.nlm.nih.gov/gene/9655 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002745 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA STAT3 http://www.ncbi.nlm.nih.gov/gene/6774 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002746 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA SYNCRIP http://www.ncbi.nlm.nih.gov/gene/10492 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002747 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA TET2 http://www.ncbi.nlm.nih.gov/gene/54790 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002748 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA TFDP1 http://www.ncbi.nlm.nih.gov/gene/7027 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002749 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA THUMPD2 http://www.ncbi.nlm.nih.gov/gene/80745 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002750 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA TMEM127 http://www.ncbi.nlm.nih.gov/gene/55654 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002751 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA TMEM170A http://www.ncbi.nlm.nih.gov/gene/124491 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002752 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA TMEM20 http://www.ncbi.nlm.nih.gov/gene/159371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002753 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA TMEM50A http://www.ncbi.nlm.nih.gov/gene/23585 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002754 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA TMEM97 http://www.ncbi.nlm.nih.gov/gene/27346 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002755 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA TNPO2 http://www.ncbi.nlm.nih.gov/gene/30000 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002756 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA TOR1AIP2 http://www.ncbi.nlm.nih.gov/gene/163590 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002757 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA TRIM13 http://www.ncbi.nlm.nih.gov/gene/10206 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002758 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA TRIM8 http://www.ncbi.nlm.nih.gov/gene/81603 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002759 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA TXN2 http://www.ncbi.nlm.nih.gov/gene/25828 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002760 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA UBE2V2 http://www.ncbi.nlm.nih.gov/gene/7336 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002761 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA UBQLN2 http://www.ncbi.nlm.nih.gov/gene/29978 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002762 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA UQCRB http://www.ncbi.nlm.nih.gov/gene/442454 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002763 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA VGLL4 http://www.ncbi.nlm.nih.gov/gene/9686 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002764 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA WASL http://www.ncbi.nlm.nih.gov/gene/8976 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002765 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA WDR20 http://www.ncbi.nlm.nih.gov/gene/91833 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002766 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA WNK1 http://www.ncbi.nlm.nih.gov/gene/65125 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002767 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA XPR1 http://www.ncbi.nlm.nih.gov/gene/9213 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002768 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA YIPF5 http://www.ncbi.nlm.nih.gov/gene/81555 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002769 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZBTB11 http://www.ncbi.nlm.nih.gov/gene/27107 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002770 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZDHHC20 http://www.ncbi.nlm.nih.gov/gene/253832 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002771 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZMYM4 http://www.ncbi.nlm.nih.gov/gene/9202 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002772 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZNF100 http://www.ncbi.nlm.nih.gov/gene/163227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002773 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZNF12 http://www.ncbi.nlm.nih.gov/gene/7559 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002774 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZNF124 http://www.ncbi.nlm.nih.gov/gene/7678 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002775 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZNF138 http://www.ncbi.nlm.nih.gov/gene/7697 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002776 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZNF200 http://www.ncbi.nlm.nih.gov/gene/7752 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002777 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZNF264 http://www.ncbi.nlm.nih.gov/gene/9422 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002778 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZNF460 http://www.ncbi.nlm.nih.gov/gene/10794 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002779 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZNF462 http://www.ncbi.nlm.nih.gov/gene/58499 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002780 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZNF468 http://www.ncbi.nlm.nih.gov/gene/90333 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002781 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZNF479 http://www.ncbi.nlm.nih.gov/gene/100170646 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002782 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZNF562 http://www.ncbi.nlm.nih.gov/gene/54811 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002783 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZNF588 http://www.ncbi.nlm.nih.gov/gene/51427 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002784 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZNF594 http://www.ncbi.nlm.nih.gov/gene/84622 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002785 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZNF605 http://www.ncbi.nlm.nih.gov/gene/100289635 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002786 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZNF615 http://www.ncbi.nlm.nih.gov/gene/284370 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002787 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZNF621 http://www.ncbi.nlm.nih.gov/gene/285268 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002788 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZNF626 http://www.ncbi.nlm.nih.gov/gene/199777 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002789 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZNF716 http://www.ncbi.nlm.nih.gov/gene/441234 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002790 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZNF805 http://www.ncbi.nlm.nih.gov/gene/390980 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002791 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(ebv-mir-bart6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 BC-1 - Host mRNA ZNF91 http://www.ncbi.nlm.nih.gov/gene/7644 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002792 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART6-5p(miR-BART6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 C666-1 cell - Host mRNA DICER1(DICER) http://www.ncbi.nlm.nih.gov/gene/23405 Downregulation Transfections of the miR-BART6-5p Antagomir, Northern Blotting, miRISC Loading Assay. 20716523 Editing of a mutation-containing pri-miR-BART6 found in Daudi Burkitt lymphoma and nasopharyngeal carcinoma C666-1 cell lines suppressed processing of miR-BART6 RNAs.miR-BART6-5p RNAs silence Dicer through multiple target sites located in the 3'-UTR of Dicer mRNA. VHID00002793 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA ADIPOR1 http://www.ncbi.nlm.nih.gov/gene/51094 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002794 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA ADSS http://www.ncbi.nlm.nih.gov/gene/159 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002795 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA AFF4 http://www.ncbi.nlm.nih.gov/gene/27125 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002796 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA ARHGAP11A http://www.ncbi.nlm.nih.gov/gene/89839 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002797 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA B4GALT1 http://www.ncbi.nlm.nih.gov/gene/2683 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002798 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA BAZ1B http://www.ncbi.nlm.nih.gov/gene/9031 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002799 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA C6orf115 http://www.ncbi.nlm.nih.gov/gene/58527 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002800 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA CCDC44 http://www.ncbi.nlm.nih.gov/gene/51204 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002801 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA CENPQ http://www.ncbi.nlm.nih.gov/gene/55166 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002802 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA CLCN3 http://www.ncbi.nlm.nih.gov/gene/1182 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002803 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA CSDE1 http://www.ncbi.nlm.nih.gov/gene/7812 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002804 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA DCTN4 http://www.ncbi.nlm.nih.gov/gene/51164 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002805 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA DHX33 http://www.ncbi.nlm.nih.gov/gene/56919 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002806 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA DKFZp586K0821 # - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002807 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA DYRK2 http://www.ncbi.nlm.nih.gov/gene/8445 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002808 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA EIF4G2 http://www.ncbi.nlm.nih.gov/gene/1982 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002809 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA ELP4 http://www.ncbi.nlm.nih.gov/gene/26610 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002810 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA GCET2 http://www.ncbi.nlm.nih.gov/gene/257144 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002811 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA GCLC http://www.ncbi.nlm.nih.gov/gene/2729 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002812 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA GNPTAB http://www.ncbi.nlm.nih.gov/gene/79158 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002813 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA HNRNPF http://www.ncbi.nlm.nih.gov/gene/3185 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002814 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA HNRNPR http://www.ncbi.nlm.nih.gov/gene/10236 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002815 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA ING3 http://www.ncbi.nlm.nih.gov/gene/54556 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002816 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA KIAA0947 http://www.ncbi.nlm.nih.gov/gene/23379 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002817 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA KIAA2026 http://www.ncbi.nlm.nih.gov/gene/158358 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002818 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA KLHL36 http://www.ncbi.nlm.nih.gov/gene/79786 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002819 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA LARP1 http://www.ncbi.nlm.nih.gov/gene/23367 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002820 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA MAP4K5 http://www.ncbi.nlm.nih.gov/gene/11183 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002821 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA MED13 http://www.ncbi.nlm.nih.gov/gene/9969 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002822 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA MIER3 http://www.ncbi.nlm.nih.gov/gene/166968 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002823 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA MOBKL1A http://www.ncbi.nlm.nih.gov/gene/92597 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002824 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA MRPL22 http://www.ncbi.nlm.nih.gov/gene/29093 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002825 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA MYPOP http://www.ncbi.nlm.nih.gov/gene/339344 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002826 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA NFKBIA http://www.ncbi.nlm.nih.gov/gene/4792 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002827 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA PAK2 http://www.ncbi.nlm.nih.gov/gene/5062 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002828 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA PATZ1 http://www.ncbi.nlm.nih.gov/gene/23598 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002829 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA PBXIP1 http://www.ncbi.nlm.nih.gov/gene/57326 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002830 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA PCMTD2 http://www.ncbi.nlm.nih.gov/gene/55251 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002831 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA PGK1 http://www.ncbi.nlm.nih.gov/gene/5230 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002832 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA PICALM http://www.ncbi.nlm.nih.gov/gene/8301 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002833 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA PNPO http://www.ncbi.nlm.nih.gov/gene/55163 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002834 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA POLD3 http://www.ncbi.nlm.nih.gov/gene/10714 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002835 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA POLR2K http://www.ncbi.nlm.nih.gov/gene/5440 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002836 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA PPP2R5A http://www.ncbi.nlm.nih.gov/gene/5525 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002837 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA PRR3 http://www.ncbi.nlm.nih.gov/gene/80742 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002838 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA RAB27A http://www.ncbi.nlm.nih.gov/gene/5873 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002839 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA RASGRP3 http://www.ncbi.nlm.nih.gov/gene/25780 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002840 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA RCSD1 http://www.ncbi.nlm.nih.gov/gene/92241 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002841 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA RHOA http://www.ncbi.nlm.nih.gov/gene/387 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002842 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA RPL5 http://www.ncbi.nlm.nih.gov/gene/647436 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002843 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA SCFD1 http://www.ncbi.nlm.nih.gov/gene/23256 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002844 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA SEC23A http://www.ncbi.nlm.nih.gov/gene/10484 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002845 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA TFEC http://www.ncbi.nlm.nih.gov/gene/22797 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002846 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA TMEM19 http://www.ncbi.nlm.nih.gov/gene/55266 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002847 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA TMF1 http://www.ncbi.nlm.nih.gov/gene/7110 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002848 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA TNFRSF1B http://www.ncbi.nlm.nih.gov/gene/7133 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002849 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA TNKS2 http://www.ncbi.nlm.nih.gov/gene/80351 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002850 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA TXNDC5 http://www.ncbi.nlm.nih.gov/gene/81567 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002851 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA WDR4 http://www.ncbi.nlm.nih.gov/gene/10785 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002852 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA YEATS4 http://www.ncbi.nlm.nih.gov/gene/8089 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002853 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA YWHAG http://www.ncbi.nlm.nih.gov/gene/7532 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002854 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA ZCCHC7 http://www.ncbi.nlm.nih.gov/gene/84186 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002855 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA ZMYND11 http://www.ncbi.nlm.nih.gov/gene/10771 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002856 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA ZNF180 http://www.ncbi.nlm.nih.gov/gene/7733 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002857 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA ZNF217 http://www.ncbi.nlm.nih.gov/gene/7764 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002858 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 Jijoye cells - Host mRNA ZNF260 http://www.ncbi.nlm.nih.gov/gene/339324 - HITS-CLIP. 22473208 Supplemental Table 8: HITS-CLIP 3'-UTR clusters with seed matches (minimum nt 2-8) to the 20 most abundant miRNAs in Jijoye cells. VHID00002859 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART7-5p(ebv-mir-bart7*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004815 BC-1 - Host mRNA EIF2C2 http://www.ncbi.nlm.nih.gov/gene/27161 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002860 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA ACVR2A http://www.ncbi.nlm.nih.gov/gene/92 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002861 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA AK3 http://www.ncbi.nlm.nih.gov/gene/50808 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002862 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA API5L1 http://www.ncbi.nlm.nih.gov/gene/8539 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002863 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA ARHGAP5 http://www.ncbi.nlm.nih.gov/gene/394 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002864 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA ATP2A2 http://www.ncbi.nlm.nih.gov/gene/488 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002865 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA ATXN7L3 http://www.ncbi.nlm.nih.gov/gene/56970 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002866 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA B4GALT5 http://www.ncbi.nlm.nih.gov/gene/9334 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002867 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA BBX http://www.ncbi.nlm.nih.gov/gene/56987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002868 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA BLOC1S2 http://www.ncbi.nlm.nih.gov/gene/282991 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002869 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA BSN http://www.ncbi.nlm.nih.gov/gene/8927 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002870 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA BTBD3 http://www.ncbi.nlm.nih.gov/gene/22903 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002871 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA BTN2A1 http://www.ncbi.nlm.nih.gov/gene/11120 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002872 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA BTN2A2 http://www.ncbi.nlm.nih.gov/gene/10385 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002873 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA C12orf4 http://www.ncbi.nlm.nih.gov/gene/283461 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002874 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA C4orf32 http://www.ncbi.nlm.nih.gov/gene/132720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002875 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA CAPRIN2 http://www.ncbi.nlm.nih.gov/gene/65981 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002876 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA CCDC91 http://www.ncbi.nlm.nih.gov/gene/55297 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002877 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA CD48 http://www.ncbi.nlm.nih.gov/gene/962 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002878 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA CDKN1A http://www.ncbi.nlm.nih.gov/gene/1026 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002879 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA CMTM6 http://www.ncbi.nlm.nih.gov/gene/54918 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002880 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA DENND1B http://www.ncbi.nlm.nih.gov/gene/163486 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002881 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA DNAJC16 http://www.ncbi.nlm.nih.gov/gene/23341 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002882 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA DNAL1 http://www.ncbi.nlm.nih.gov/gene/83544 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002883 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA EHF http://www.ncbi.nlm.nih.gov/gene/26298 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002884 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA ELK4 http://www.ncbi.nlm.nih.gov/gene/2005 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002885 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA EXPH5 http://www.ncbi.nlm.nih.gov/gene/23086 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002886 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA FAM126B http://www.ncbi.nlm.nih.gov/gene/285172 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002887 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA FAM177A1 http://www.ncbi.nlm.nih.gov/gene/283635 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002888 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA GARS http://www.ncbi.nlm.nih.gov/gene/2617 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002889 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA GATAD2B http://www.ncbi.nlm.nih.gov/gene/57459 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002890 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA GLT8D3 http://www.ncbi.nlm.nih.gov/gene/283464 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002891 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA IRF2 http://www.ncbi.nlm.nih.gov/gene/3660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002892 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA IVD http://www.ncbi.nlm.nih.gov/gene/3712 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002893 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA KLF10 http://www.ncbi.nlm.nih.gov/gene/7071 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002894 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA KLHL18 http://www.ncbi.nlm.nih.gov/gene/23276 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002895 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA KPNA3 http://www.ncbi.nlm.nih.gov/gene/3839 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002896 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA LAMC1 http://www.ncbi.nlm.nih.gov/gene/3915 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002897 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA LARP4B http://www.ncbi.nlm.nih.gov/gene/23185 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002898 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA MAK16 http://www.ncbi.nlm.nih.gov/gene/84549 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002899 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA MAPKSP1 http://www.ncbi.nlm.nih.gov/gene/8649 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002900 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA MAT2B http://www.ncbi.nlm.nih.gov/gene/27430 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002901 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA MIER3 http://www.ncbi.nlm.nih.gov/gene/166968 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002902 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA NHLRC2 http://www.ncbi.nlm.nih.gov/gene/374354 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002903 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA NUDT5 http://www.ncbi.nlm.nih.gov/gene/11164 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002904 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA ORC5L http://www.ncbi.nlm.nih.gov/gene/5001 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002905 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA PPAT http://www.ncbi.nlm.nih.gov/gene/5471 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002906 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA PPM1F http://www.ncbi.nlm.nih.gov/gene/9647 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002907 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA PRDM1 http://www.ncbi.nlm.nih.gov/gene/639 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002908 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA PREB http://www.ncbi.nlm.nih.gov/gene/10113 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002909 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA PRMT2 http://www.ncbi.nlm.nih.gov/gene/3275 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002910 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA QSER1 http://www.ncbi.nlm.nih.gov/gene/79832 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002911 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA RAB11FIP2 http://www.ncbi.nlm.nih.gov/gene/22841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002912 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA RALGPS2 http://www.ncbi.nlm.nih.gov/gene/55103 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002913 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA RAVER2 http://www.ncbi.nlm.nih.gov/gene/55225 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002914 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA REV3L http://www.ncbi.nlm.nih.gov/gene/5980 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002915 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA RFX7 http://www.ncbi.nlm.nih.gov/gene/64864 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002916 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA RIF1 http://www.ncbi.nlm.nih.gov/gene/55183 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002917 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA RNF168 http://www.ncbi.nlm.nih.gov/gene/165918 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002918 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA RORA http://www.ncbi.nlm.nih.gov/gene/6095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002919 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA RYBP http://www.ncbi.nlm.nih.gov/gene/23429 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002920 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA SASS6 http://www.ncbi.nlm.nih.gov/gene/163786 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002921 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA SDHAF1 http://www.ncbi.nlm.nih.gov/gene/644096 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002922 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA SLC19A2 http://www.ncbi.nlm.nih.gov/gene/10560 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002923 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA SLC26A11 http://www.ncbi.nlm.nih.gov/gene/284129 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002924 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA SLC35D1 http://www.ncbi.nlm.nih.gov/gene/23169 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002925 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA SPRYD4 http://www.ncbi.nlm.nih.gov/gene/283377 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002926 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA SSR3 http://www.ncbi.nlm.nih.gov/gene/6747 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002927 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA TAOK3 http://www.ncbi.nlm.nih.gov/gene/51347 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002928 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA TCEB3 http://www.ncbi.nlm.nih.gov/gene/6924 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002929 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA TGS1 http://www.ncbi.nlm.nih.gov/gene/96764 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002930 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA THUMPD1 http://www.ncbi.nlm.nih.gov/gene/55623 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002931 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA TIMM9 http://www.ncbi.nlm.nih.gov/gene/26520 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002932 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA TM9SF3 http://www.ncbi.nlm.nih.gov/gene/56889 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002933 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA TMEM64 http://www.ncbi.nlm.nih.gov/gene/169200 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002934 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA TMF1 http://www.ncbi.nlm.nih.gov/gene/7110 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002935 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA TPD52 http://www.ncbi.nlm.nih.gov/gene/7163 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002936 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA TRIB1 http://www.ncbi.nlm.nih.gov/gene/10221 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002937 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA TSPYL1 http://www.ncbi.nlm.nih.gov/gene/7259 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002938 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA UBN2 http://www.ncbi.nlm.nih.gov/gene/254048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002939 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA VTI1B http://www.ncbi.nlm.nih.gov/gene/10490 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002940 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA WDR1 http://www.ncbi.nlm.nih.gov/gene/9948 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002941 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA XPO6 http://www.ncbi.nlm.nih.gov/gene/23214 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002942 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA ZFAND3 http://www.ncbi.nlm.nih.gov/gene/60685 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002943 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA ZFP36L2 http://www.ncbi.nlm.nih.gov/gene/678 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002944 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA ZNF419 http://www.ncbi.nlm.nih.gov/gene/79744 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002945 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART8-3p(ebv-mir-bart8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003418 BC-1 - Host mRNA ZNF493 http://www.ncbi.nlm.nih.gov/gene/284443 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002946 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA ADAR http://www.ncbi.nlm.nih.gov/gene/103 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002947 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA ANKHD1 http://www.ncbi.nlm.nih.gov/gene/8637 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002948 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA ATXN1 http://www.ncbi.nlm.nih.gov/gene/6310 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002949 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA BMI1 http://www.ncbi.nlm.nih.gov/gene/648 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002950 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA C11orf30 http://www.ncbi.nlm.nih.gov/gene/56946 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002951 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA C15orf17 http://www.ncbi.nlm.nih.gov/gene/57184 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002952 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA C5orf28 http://www.ncbi.nlm.nih.gov/gene/64417 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002953 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA CAPRIN1 http://www.ncbi.nlm.nih.gov/gene/4076 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002954 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA CAPZA2 http://www.ncbi.nlm.nih.gov/gene/830 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002955 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA CASP7 http://www.ncbi.nlm.nih.gov/gene/840 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002956 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA CDK8 http://www.ncbi.nlm.nih.gov/gene/1024 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002957 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA CLASP1 http://www.ncbi.nlm.nih.gov/gene/23332 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002958 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA DDX6 http://www.ncbi.nlm.nih.gov/gene/1656 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002959 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA EIF3L http://www.ncbi.nlm.nih.gov/gene/51386 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002960 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA ELAC1 http://www.ncbi.nlm.nih.gov/gene/55520 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002961 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA FNBP4 http://www.ncbi.nlm.nih.gov/gene/23360 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002962 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA FRS2 http://www.ncbi.nlm.nih.gov/gene/10818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002963 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA GLS http://www.ncbi.nlm.nih.gov/gene/2744 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002964 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA HSDL1 http://www.ncbi.nlm.nih.gov/gene/83693 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002965 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA JAG1 http://www.ncbi.nlm.nih.gov/gene/182 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002966 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA KIAA1712 http://www.ncbi.nlm.nih.gov/gene/80817 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002967 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA LCOR http://www.ncbi.nlm.nih.gov/gene/84458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002968 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA MAP3K5 http://www.ncbi.nlm.nih.gov/gene/4217 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002969 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA MBIP http://www.ncbi.nlm.nih.gov/gene/51562 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002970 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA NDRG3 http://www.ncbi.nlm.nih.gov/gene/57446 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002971 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA NR3C1 http://www.ncbi.nlm.nih.gov/gene/2908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002972 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA NUCKS1 http://www.ncbi.nlm.nih.gov/gene/64710 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002973 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA PARP6 http://www.ncbi.nlm.nih.gov/gene/56965 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002974 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA PIM2 http://www.ncbi.nlm.nih.gov/gene/11040 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002975 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA POU2F1 http://www.ncbi.nlm.nih.gov/gene/5451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002976 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA PRKAR1A http://www.ncbi.nlm.nih.gov/gene/5573 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002977 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA PSMD13 http://www.ncbi.nlm.nih.gov/gene/5719 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002978 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA RABL5 http://www.ncbi.nlm.nih.gov/gene/64792 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002979 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA RAD21 http://www.ncbi.nlm.nih.gov/gene/5885 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002980 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA RNF169 http://www.ncbi.nlm.nih.gov/gene/254225 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002981 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA RNF38 http://www.ncbi.nlm.nih.gov/gene/152006 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002982 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA SNX10 http://www.ncbi.nlm.nih.gov/gene/29887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002983 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA SP3 http://www.ncbi.nlm.nih.gov/gene/6670 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002984 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA SS18 http://www.ncbi.nlm.nih.gov/gene/6760 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002985 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA STYX http://www.ncbi.nlm.nih.gov/gene/6815 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002986 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA TCF3 http://www.ncbi.nlm.nih.gov/gene/6929 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002987 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA TRIM4 http://www.ncbi.nlm.nih.gov/gene/89122 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002988 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA ZBTB10 http://www.ncbi.nlm.nih.gov/gene/65986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002989 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA ZMAT3 http://www.ncbi.nlm.nih.gov/gene/64393 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002990 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA ZMYND8 http://www.ncbi.nlm.nih.gov/gene/23613 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002991 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA ZNF317 http://www.ncbi.nlm.nih.gov/gene/57693 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002992 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA ZNF673 http://www.ncbi.nlm.nih.gov/gene/55634 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002993 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA ZNF740 http://www.ncbi.nlm.nih.gov/gene/283337 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002994 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART9-5p(ebv-mir-bart9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004816 BC-1 - Host mRNA ZSCAN29 http://www.ncbi.nlm.nih.gov/gene/146050 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00002995 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA AKAP11 http://www.ncbi.nlm.nih.gov/gene/11215 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00002996 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA ARFGEF1 http://www.ncbi.nlm.nih.gov/gene/10565 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00002997 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA BBS2 http://www.ncbi.nlm.nih.gov/gene/583 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00002998 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA BIRC3 http://www.ncbi.nlm.nih.gov/gene/330 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00002999 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA CEP57 http://www.ncbi.nlm.nih.gov/gene/9702 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003000 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA FBXO33 http://www.ncbi.nlm.nih.gov/gene/254170 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003001 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA FZD3 http://www.ncbi.nlm.nih.gov/gene/7976 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003002 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA GAS7 http://www.ncbi.nlm.nih.gov/gene/8522 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003003 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA GDI2 http://www.ncbi.nlm.nih.gov/gene/2665 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003004 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA GNAS http://www.ncbi.nlm.nih.gov/gene/2778 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003005 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA GTF3C3 http://www.ncbi.nlm.nih.gov/gene/9330 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003006 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA GTPBP4 http://www.ncbi.nlm.nih.gov/gene/23560 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003007 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA HIPK3 http://www.ncbi.nlm.nih.gov/gene/10114 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003008 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA INPP5D http://www.ncbi.nlm.nih.gov/gene/3635 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003009 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA IPO11 http://www.ncbi.nlm.nih.gov/gene/51194 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003010 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA ITGAV http://www.ncbi.nlm.nih.gov/gene/3685 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003011 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA KDM4B http://www.ncbi.nlm.nih.gov/gene/23030 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003012 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA KPNB1 http://www.ncbi.nlm.nih.gov/gene/3837 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003013 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA MALT1 http://www.ncbi.nlm.nih.gov/gene/10892 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003014 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA MEX3C http://www.ncbi.nlm.nih.gov/gene/51320 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003015 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA MYC http://www.ncbi.nlm.nih.gov/gene/4609 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003016 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA MYO5A http://www.ncbi.nlm.nih.gov/gene/4644 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003017 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA PANK3 http://www.ncbi.nlm.nih.gov/gene/79646 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003018 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA PARP9 http://www.ncbi.nlm.nih.gov/gene/83666 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003019 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA PCNXL3 http://www.ncbi.nlm.nih.gov/gene/399909 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003020 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA PDCD1LG2 http://www.ncbi.nlm.nih.gov/gene/80380 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003021 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA PHC3 http://www.ncbi.nlm.nih.gov/gene/80012 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003022 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA PPP2R2A http://www.ncbi.nlm.nih.gov/gene/5520 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003023 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA RAB3GAP2 http://www.ncbi.nlm.nih.gov/gene/25782 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003024 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA RCN2 http://www.ncbi.nlm.nih.gov/gene/5955 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003025 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA RIF1 http://www.ncbi.nlm.nih.gov/gene/55183 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003026 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA SCP2 http://www.ncbi.nlm.nih.gov/gene/6342 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003027 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA SERP1 http://www.ncbi.nlm.nih.gov/gene/27230 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003028 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA SNX27 http://www.ncbi.nlm.nih.gov/gene/81609 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003029 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA SON http://www.ncbi.nlm.nih.gov/gene/6651 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003030 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA SOS1 http://www.ncbi.nlm.nih.gov/gene/6654 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003031 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA SSR3 http://www.ncbi.nlm.nih.gov/gene/6747 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003032 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA UBE2E2 http://www.ncbi.nlm.nih.gov/gene/7325 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003033 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA VASH2 http://www.ncbi.nlm.nih.gov/gene/79805 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003034 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA YTHDC2 http://www.ncbi.nlm.nih.gov/gene/64848 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003035 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-2-5p(ebv-mir-bhrf1-2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 Lymphoblastoid cell lines - Host mRNA ZNF644 http://www.ncbi.nlm.nih.gov/gene/84146 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003036 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BHRF1-3(miR-BHRF1-3) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000998 - - Host mRNA CXCL11 http://www.ncbi.nlm.nih.gov/gene/6373 - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VHID00003037 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BRAT2-3p(ebv-mir-bart2-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004744 Lymphoblastoid cell lines - Host mRNA IER3 http://www.ncbi.nlm.nih.gov/gene/8870 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003038 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART1(BART-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001067 - - Host Protein CLIP1 http://www.ncbi.nlm.nih.gov/gene/6249 - PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 BART1 binds the 3'UTR of CLIP1/CLIP-170 as demonstrated using PAR-CLIP and luciferase assays. VHID00003039 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART1(BART-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001067 - - Host Protein LY75 http://www.ncbi.nlm.nih.gov/gene/4065 - PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 For each of them, direct interactions between 3'UTR and EBV miRNAs were confirmed by luciferase assay but no functional assay has been performed so far (Table 2).Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation (PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP) or RNA immunoprecipitation and microarray (RIP-Chip) techniques. Validation of these targets was done using luciferase reporter assays. VHID00003040 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART1(BART-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001067 - - Host Protein PDE7A http://www.ncbi.nlm.nih.gov/gene/5150 - PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 For each of them, direct interactions between 3'UTR and EBV miRNAs were confirmed by luciferase assay but no functional assay has been performed so far (Table 2).Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation (PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP) or RNA immunoprecipitation and microarray (RIP-Chip) techniques. Validation of these targets was done using luciferase reporter assays. VHID00003041 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART1(BART-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001067 - - Host Protein SP100 http://www.ncbi.nlm.nih.gov/gene/6672 - PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 For each of them, direct interactions between 3'UTR and EBV miRNAs were confirmed by luciferase assay but no functional assay has been performed so far (Table 2).Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation (PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP) or RNA immunoprecipitation and microarray (RIP-Chip) techniques. Validation of these targets was done using luciferase reporter assays. VHID00003042 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART1(BART1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001067 - - Host mRNA CLEC2D http://www.ncbi.nlm.nih.gov/gene/29121 - PAR-CLIP. 23170179 In addition, CLEC2D/LLT1 was identified as a target of BART1 and BART3 by PAR-CLIP. VHID00003043 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART1(miR-BART1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001067 epithelial cell lines - Host Protein BCL2L11(BimEL) http://www.ncbi.nlm.nih.gov/gene/396632 Downregulation Northern Blot analysis and quantitative RT-PCR, Western Blot analysis, Microarray analysis, ciferase Assays. 21333317 Analysis of the BimEL protein levels in cells expressing the miRNAs revealed that its expression was affected by several of the individual miRNAs with cell lines expressing miR-BART1, 3, 9, 11 and 12 all having decreased BimEL levels (Figure 6B and C). VHID00003044 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART1(miR-BART1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001067 epithelial cell lines - Host mRNA BCL2L11(BIM) http://www.ncbi.nlm.nih.gov/gene/396632 Downregulation Northern Blot analysis and quantitative RT-PCR, Western Blot analysis, Microarray analysis, ciferase Assays. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VHID00003045 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART1(mir-BART1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001067 B cell lymphomagenesis - Host mRNA CLEC2D http://www.ncbi.nlm.nih.gov/gene/29121 - Western Blotting, Northern Blotting, Luciferase Reporter Assay. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VHID00003046 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART1(mir-BART1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001067 B cell lymphomagenesis - Host mRNA DICER1 http://www.ncbi.nlm.nih.gov/gene/23405 - Western Blotting, Northern Blotting, Luciferase Reporter Assay. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VHID00003047 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART1(mir-BART1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001067 B cell lymphomagenesis - Host mRNA LY75 http://www.ncbi.nlm.nih.gov/gene/4065 - Western Blotting, Northern Blotting, Luciferase Reporter Assay. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VHID00003048 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART1(mir-BART1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001067 B cell lymphomagenesis - Host mRNA MICB http://www.ncbi.nlm.nih.gov/gene/4277 - Western Blotting, Northern Blotting, Luciferase Reporter Assay. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VHID00003049 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART1(mir-BART1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001067 B cell lymphomagenesis - Host mRNA SP100 http://www.ncbi.nlm.nih.gov/gene/6672 - Western Blotting, Northern Blotting, Luciferase Reporter Assay. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VHID00003050 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA ABHD13 http://www.ncbi.nlm.nih.gov/gene/84945 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003051 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA ABI1 http://www.ncbi.nlm.nih.gov/gene/10006 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003052 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA ACADM http://www.ncbi.nlm.nih.gov/gene/34 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003053 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA ACSL4 http://www.ncbi.nlm.nih.gov/gene/2182 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003054 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA AK3L1 http://www.ncbi.nlm.nih.gov/gene/645619 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003055 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA ANKRD11 http://www.ncbi.nlm.nih.gov/gene/100128265 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003056 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA AP1S3 http://www.ncbi.nlm.nih.gov/gene/130340 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003057 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA AP3S1 http://www.ncbi.nlm.nih.gov/gene/1176 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003058 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA ASH1L http://www.ncbi.nlm.nih.gov/gene/55870 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003059 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA ASZ1 http://www.ncbi.nlm.nih.gov/gene/136991 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003060 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA ATF6 http://www.ncbi.nlm.nih.gov/gene/22926 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003061 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA ATP6V0E1 http://www.ncbi.nlm.nih.gov/gene/8992 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003062 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA ATP6V1C1 http://www.ncbi.nlm.nih.gov/gene/528 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003063 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA BOD1L http://www.ncbi.nlm.nih.gov/gene/259282 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003064 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA BTBD3 http://www.ncbi.nlm.nih.gov/gene/22903 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003065 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA BXDC5 http://www.ncbi.nlm.nih.gov/gene/80135 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003066 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA C12orf26 http://www.ncbi.nlm.nih.gov/gene/84190 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003067 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA C12orf30 http://www.ncbi.nlm.nih.gov/gene/80018 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003068 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA C12orf5 http://www.ncbi.nlm.nih.gov/gene/57103 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003069 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA C14orf166 http://www.ncbi.nlm.nih.gov/gene/51637 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003070 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA C15orf23 http://www.ncbi.nlm.nih.gov/gene/90417 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003071 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA CCNL1 http://www.ncbi.nlm.nih.gov/gene/57018 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003072 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA CD86 http://www.ncbi.nlm.nih.gov/gene/942 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003073 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA CDC2L5 http://www.ncbi.nlm.nih.gov/gene/8621 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003074 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA CDC2L6 http://www.ncbi.nlm.nih.gov/gene/23097 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003075 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA CDKN1B http://www.ncbi.nlm.nih.gov/gene/1027 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003076 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA CFH http://www.ncbi.nlm.nih.gov/gene/3075 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003077 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA CHCHD2 http://www.ncbi.nlm.nih.gov/gene/51142 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003078 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA CHIC2 http://www.ncbi.nlm.nih.gov/gene/26511 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003079 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA CHORDC1 http://www.ncbi.nlm.nih.gov/gene/26973 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003080 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA CLINT1 http://www.ncbi.nlm.nih.gov/gene/9685 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003081 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA CMTM6 http://www.ncbi.nlm.nih.gov/gene/54918 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003082 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA CPEB4 http://www.ncbi.nlm.nih.gov/gene/80315 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003083 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA CREB3L4 http://www.ncbi.nlm.nih.gov/gene/148327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003084 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA CXXC4 http://www.ncbi.nlm.nih.gov/gene/80319 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003085 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA DARS http://www.ncbi.nlm.nih.gov/gene/1615 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003086 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA DNAJB4 http://www.ncbi.nlm.nih.gov/gene/11080 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003087 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA DUSP11 http://www.ncbi.nlm.nih.gov/gene/8446 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003088 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA DYRK1A http://www.ncbi.nlm.nih.gov/gene/1859 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003089 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA EIF2C2 http://www.ncbi.nlm.nih.gov/gene/27161 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003090 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA ELK4 http://www.ncbi.nlm.nih.gov/gene/2005 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003091 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA EPDR1 http://www.ncbi.nlm.nih.gov/gene/54749 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003092 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA FAM111A http://www.ncbi.nlm.nih.gov/gene/63901 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003093 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA FAM126B http://www.ncbi.nlm.nih.gov/gene/285172 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003094 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA FBXO28 http://www.ncbi.nlm.nih.gov/gene/23219 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003095 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA FBXW7 http://www.ncbi.nlm.nih.gov/gene/55294 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003096 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA FGD4 http://www.ncbi.nlm.nih.gov/gene/121512 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003097 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA FOXN2 http://www.ncbi.nlm.nih.gov/gene/3344 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003098 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA FRS2 http://www.ncbi.nlm.nih.gov/gene/10818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003099 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA FZD6 http://www.ncbi.nlm.nih.gov/gene/8323 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003100 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA HIST1H2BB http://www.ncbi.nlm.nih.gov/gene/3018 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003101 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA HMGCL http://www.ncbi.nlm.nih.gov/gene/3155 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003102 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA IREB2 http://www.ncbi.nlm.nih.gov/gene/3658 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003103 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA IRF4 http://www.ncbi.nlm.nih.gov/gene/3662 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003104 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA JMY http://www.ncbi.nlm.nih.gov/gene/133746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003105 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA KCTD2 http://www.ncbi.nlm.nih.gov/gene/23510 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003106 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA KDELR2 http://www.ncbi.nlm.nih.gov/gene/11014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003107 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA KIAA1279 http://www.ncbi.nlm.nih.gov/gene/26128 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003108 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA KIAA1586 http://www.ncbi.nlm.nih.gov/gene/57691 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003109 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA KLF3 http://www.ncbi.nlm.nih.gov/gene/51274 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003110 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA KLHL3 http://www.ncbi.nlm.nih.gov/gene/26249 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003111 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA KLHL36 http://www.ncbi.nlm.nih.gov/gene/79786 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003112 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA LANCL1 http://www.ncbi.nlm.nih.gov/gene/10314 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003113 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA LDLR http://www.ncbi.nlm.nih.gov/gene/3949 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003114 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA LIN7C http://www.ncbi.nlm.nih.gov/gene/55327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003115 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA LMBR1 http://www.ncbi.nlm.nih.gov/gene/64327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003116 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA LRRFIP1 http://www.ncbi.nlm.nih.gov/gene/9208 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003117 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA LSM11 http://www.ncbi.nlm.nih.gov/gene/134353 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003118 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA MAP4K3 http://www.ncbi.nlm.nih.gov/gene/8491 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003119 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA MAT2B http://www.ncbi.nlm.nih.gov/gene/27430 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003120 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA MBNL1 http://www.ncbi.nlm.nih.gov/gene/4154 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003121 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA MBNL3 http://www.ncbi.nlm.nih.gov/gene/55796 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003122 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA MCL1 http://www.ncbi.nlm.nih.gov/gene/4170 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003123 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA MED13L http://www.ncbi.nlm.nih.gov/gene/23389 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003124 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA METAP2 http://www.ncbi.nlm.nih.gov/gene/10988 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003125 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA MEX3B http://www.ncbi.nlm.nih.gov/gene/84206 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003126 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA MEX3C http://www.ncbi.nlm.nih.gov/gene/51320 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003127 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA MOBKL3 http://www.ncbi.nlm.nih.gov/gene/25843 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003128 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA MOCS3 http://www.ncbi.nlm.nih.gov/gene/27304 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003129 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA MRFAP1 http://www.ncbi.nlm.nih.gov/gene/93621 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003130 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA MSN http://www.ncbi.nlm.nih.gov/gene/4478 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003131 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA MTFMT http://www.ncbi.nlm.nih.gov/gene/123263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003132 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA NAPB http://www.ncbi.nlm.nih.gov/gene/63908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003133 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA NEK7 http://www.ncbi.nlm.nih.gov/gene/140609 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003134 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA NFIA http://www.ncbi.nlm.nih.gov/gene/4774 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003135 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003136 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA NOTCH1 http://www.ncbi.nlm.nih.gov/gene/4851 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003137 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA PALM2-AKAP2 http://www.ncbi.nlm.nih.gov/gene/114299 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003138 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA PATL1 http://www.ncbi.nlm.nih.gov/gene/219988 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003139 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA PBXIP1 http://www.ncbi.nlm.nih.gov/gene/57326 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003140 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA PHF6 http://www.ncbi.nlm.nih.gov/gene/84295 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003141 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA POLR1E http://www.ncbi.nlm.nih.gov/gene/64425 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003142 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA QRICH1 http://www.ncbi.nlm.nih.gov/gene/54870 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003143 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA RAB7A http://www.ncbi.nlm.nih.gov/gene/7879 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003144 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA RAD21 http://www.ncbi.nlm.nih.gov/gene/5885 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003145 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA RB1CC1 http://www.ncbi.nlm.nih.gov/gene/9821 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003146 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA RC3H2 http://www.ncbi.nlm.nih.gov/gene/54542 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003147 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA REV3L http://www.ncbi.nlm.nih.gov/gene/5980 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003148 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA RFK http://www.ncbi.nlm.nih.gov/gene/55312 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003149 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA RHOU http://www.ncbi.nlm.nih.gov/gene/58480 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003150 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA RMND5A http://www.ncbi.nlm.nih.gov/gene/64795 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003151 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA RNF19A http://www.ncbi.nlm.nih.gov/gene/25897 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003152 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA RYBP http://www.ncbi.nlm.nih.gov/gene/23429 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003153 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA SAP18 http://www.ncbi.nlm.nih.gov/gene/10284 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003154 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA SEC23A http://www.ncbi.nlm.nih.gov/gene/10484 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003155 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA SEPHS1 http://www.ncbi.nlm.nih.gov/gene/389873 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003156 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA SFPQ http://www.ncbi.nlm.nih.gov/gene/6421 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003157 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA SFRS18 http://www.ncbi.nlm.nih.gov/gene/25957 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003158 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA SLC38A2 http://www.ncbi.nlm.nih.gov/gene/54407 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003159 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA SMAD4 http://www.ncbi.nlm.nih.gov/gene/4089 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003160 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA SMC1A http://www.ncbi.nlm.nih.gov/gene/8243 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003161 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA SMC5 http://www.ncbi.nlm.nih.gov/gene/23137 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003162 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA SNAPC3 http://www.ncbi.nlm.nih.gov/gene/6619 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003163 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA SNRK http://www.ncbi.nlm.nih.gov/gene/54861 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003164 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA SNX10 http://www.ncbi.nlm.nih.gov/gene/29887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003165 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA SRI http://www.ncbi.nlm.nih.gov/gene/6717 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003166 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA SSFA2 http://www.ncbi.nlm.nih.gov/gene/6744 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003167 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA TAF8 http://www.ncbi.nlm.nih.gov/gene/129685 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003168 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA TP53INP1 http://www.ncbi.nlm.nih.gov/gene/94241 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003169 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA TRA2A http://www.ncbi.nlm.nih.gov/gene/29896 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003170 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA TRIP13 http://www.ncbi.nlm.nih.gov/gene/9319 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003171 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA TRPM8 http://www.ncbi.nlm.nih.gov/gene/79054 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003172 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA UBE2E1 http://www.ncbi.nlm.nih.gov/gene/7324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003173 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA UBN2 http://www.ncbi.nlm.nih.gov/gene/254048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003174 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA UNC5CL http://www.ncbi.nlm.nih.gov/gene/222643 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003175 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA UXS1 http://www.ncbi.nlm.nih.gov/gene/80146 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003176 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA YOD1 http://www.ncbi.nlm.nih.gov/gene/55432 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003177 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA YWHAG http://www.ncbi.nlm.nih.gov/gene/7532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003178 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA ZBED4 http://www.ncbi.nlm.nih.gov/gene/9889 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003179 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA ZC3H11A http://www.ncbi.nlm.nih.gov/gene/9877 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003180 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA ZC3H13 http://www.ncbi.nlm.nih.gov/gene/23091 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003181 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA ZFAND5 http://www.ncbi.nlm.nih.gov/gene/732229 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003182 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA ZMAT3 http://www.ncbi.nlm.nih.gov/gene/64393 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003183 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA ZNF451 http://www.ncbi.nlm.nih.gov/gene/26036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003184 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA ZNF592 http://www.ncbi.nlm.nih.gov/gene/9640 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003185 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(ebv-mir-bart10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 BC-1 - Host mRNA ZNF608 http://www.ncbi.nlm.nih.gov/gene/57507 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003186 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART11(miR-BART11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003733 epithelial cell lines - Host Protein BCL2L11(BimEL) http://www.ncbi.nlm.nih.gov/gene/396632 Downregulation Northern Blot analysis and quantitative RT-PCR, Western Blot analysis, Microarray analysis, ciferase Assays. 21333317 Analysis of the BimEL protein levels in cells expressing the miRNAs revealed that its expression was affected by several of the individual miRNAs with cell lines expressing miR-BART1, 3, 9, 11 and 12 all having decreased BimEL levels (Figure 6B and C). VHID00003187 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART11(miR-BART11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003733 epithelial cell lines - Host mRNA BCL2L11(BIM) http://www.ncbi.nlm.nih.gov/gene/396632 Downregulation Northern Blot analysis and quantitative RT-PCR, Western Blot analysis, Microarray analysis, ciferase Assays. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VHID00003188 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA MARCH9 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003189 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA ACLY http://www.ncbi.nlm.nih.gov/gene/47 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003190 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA ACTR1B http://www.ncbi.nlm.nih.gov/gene/10120 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003191 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA APLP2 http://www.ncbi.nlm.nih.gov/gene/334 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003192 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA ATL2 http://www.ncbi.nlm.nih.gov/gene/64225 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003193 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA BNC2 http://www.ncbi.nlm.nih.gov/gene/54796 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003194 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA C22orf30 http://www.ncbi.nlm.nih.gov/gene/253143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003195 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA C3orf23 http://www.ncbi.nlm.nih.gov/gene/285343 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003196 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA CDKN1B http://www.ncbi.nlm.nih.gov/gene/1027 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003197 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA CLSTN1 http://www.ncbi.nlm.nih.gov/gene/22883 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003198 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA CTDSPL2 http://www.ncbi.nlm.nih.gov/gene/51496 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003199 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA FYCO1 http://www.ncbi.nlm.nih.gov/gene/79443 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003200 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA ISG20L2 http://www.ncbi.nlm.nih.gov/gene/81875 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003201 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA KIAA0831 http://www.ncbi.nlm.nih.gov/gene/22863 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003202 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA KIAA1211 http://www.ncbi.nlm.nih.gov/gene/57482 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003203 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA LRRK1 http://www.ncbi.nlm.nih.gov/gene/79705 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003204 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA MKL2 http://www.ncbi.nlm.nih.gov/gene/57496 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003205 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA MLLT3 http://www.ncbi.nlm.nih.gov/gene/4300 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003206 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA NCBP2 http://www.ncbi.nlm.nih.gov/gene/22916 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003207 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA NHLRC2 http://www.ncbi.nlm.nih.gov/gene/374354 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003208 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA PI4KB http://www.ncbi.nlm.nih.gov/gene/5298 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003209 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA PPIB http://www.ncbi.nlm.nih.gov/gene/5479 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003210 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA PPP1R10 http://www.ncbi.nlm.nih.gov/gene/5514 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003211 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA RAB30 http://www.ncbi.nlm.nih.gov/gene/27314 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003212 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA RIT1 http://www.ncbi.nlm.nih.gov/gene/6016 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003213 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA RPS6KB1 http://www.ncbi.nlm.nih.gov/gene/6198 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003214 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA SCD http://www.ncbi.nlm.nih.gov/gene/6319 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003215 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA SLAMF7 http://www.ncbi.nlm.nih.gov/gene/57823 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003216 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA SLC38A2 http://www.ncbi.nlm.nih.gov/gene/54407 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003217 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA STAT3 http://www.ncbi.nlm.nih.gov/gene/6774 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003218 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA TADA1L http://www.ncbi.nlm.nih.gov/gene/117143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003219 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA TOMM5 http://www.ncbi.nlm.nih.gov/gene/401505 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003220 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA TRIM26 http://www.ncbi.nlm.nih.gov/gene/7726 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003221 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA USP22 http://www.ncbi.nlm.nih.gov/gene/23326 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003222 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART12(ebv-mir-bart12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003734 BC-1 - Host mRNA WDR32 http://www.ncbi.nlm.nih.gov/gene/79269 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003223 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA AASDHPPT http://www.ncbi.nlm.nih.gov/gene/60496 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003224 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA ACOT9 http://www.ncbi.nlm.nih.gov/gene/23597 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003225 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA ADAM17 http://www.ncbi.nlm.nih.gov/gene/6868 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003226 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA ARPP19 http://www.ncbi.nlm.nih.gov/gene/646227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003227 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA BAZ2B http://www.ncbi.nlm.nih.gov/gene/29994 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003228 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA BCORL1 http://www.ncbi.nlm.nih.gov/gene/63035 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003229 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA BNC2 http://www.ncbi.nlm.nih.gov/gene/54796 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003230 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA C1orf55 http://www.ncbi.nlm.nih.gov/gene/163859 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003231 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA C4orf46 http://www.ncbi.nlm.nih.gov/gene/201725 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003232 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA C5orf24 http://www.ncbi.nlm.nih.gov/gene/134553 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003233 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA C6orf120 http://www.ncbi.nlm.nih.gov/gene/387263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003234 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA C6orf211 http://www.ncbi.nlm.nih.gov/gene/79624 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003235 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA CCNE2 http://www.ncbi.nlm.nih.gov/gene/9134 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003236 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA CDC27 http://www.ncbi.nlm.nih.gov/gene/996 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003237 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA CDC73 http://www.ncbi.nlm.nih.gov/gene/79577 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003238 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA CDCA5 http://www.ncbi.nlm.nih.gov/gene/113130 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003239 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA CLDND1 http://www.ncbi.nlm.nih.gov/gene/56650 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003240 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA CLGN http://www.ncbi.nlm.nih.gov/gene/1047 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003241 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA CLPX http://www.ncbi.nlm.nih.gov/gene/10845 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003242 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA CPEB4 http://www.ncbi.nlm.nih.gov/gene/80315 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003243 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA CSTF2T http://www.ncbi.nlm.nih.gov/gene/23283 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003244 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA CXCR4 http://www.ncbi.nlm.nih.gov/gene/7852 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003245 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA CYP4F3 http://www.ncbi.nlm.nih.gov/gene/4051 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003246 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA DDI2 http://www.ncbi.nlm.nih.gov/gene/84301 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003247 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA DENND5B http://www.ncbi.nlm.nih.gov/gene/160518 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003248 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA DLG5 http://www.ncbi.nlm.nih.gov/gene/9231 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003249 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA EAF1 http://www.ncbi.nlm.nih.gov/gene/85403 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003250 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA EIF5 http://www.ncbi.nlm.nih.gov/gene/1983 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003251 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA ELF2 http://www.ncbi.nlm.nih.gov/gene/1998 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003252 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA ELK4 http://www.ncbi.nlm.nih.gov/gene/2005 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003253 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA ENC1 http://www.ncbi.nlm.nih.gov/gene/8507 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003254 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA EPHA5 http://www.ncbi.nlm.nih.gov/gene/2044 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003255 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA FAM49B http://www.ncbi.nlm.nih.gov/gene/51571 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003256 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA FAM63B http://www.ncbi.nlm.nih.gov/gene/54629 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003257 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA FEM1C http://www.ncbi.nlm.nih.gov/gene/56929 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003258 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA FOXP2 http://www.ncbi.nlm.nih.gov/gene/93986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003259 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA FRMD5 http://www.ncbi.nlm.nih.gov/gene/84978 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003260 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA FZD5 http://www.ncbi.nlm.nih.gov/gene/7855 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003261 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA GAB1 http://www.ncbi.nlm.nih.gov/gene/2549 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003262 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA IAH1 http://www.ncbi.nlm.nih.gov/gene/285148 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003263 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA IER3IP1 http://www.ncbi.nlm.nih.gov/gene/51124 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003264 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA IFNAR1 http://www.ncbi.nlm.nih.gov/gene/3454 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003265 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA IK http://www.ncbi.nlm.nih.gov/gene/3550 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003266 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA IL10 http://www.ncbi.nlm.nih.gov/gene/3586 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003267 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA JMY http://www.ncbi.nlm.nih.gov/gene/133746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003268 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA KIAA0494 http://www.ncbi.nlm.nih.gov/gene/9813 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003269 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA KLHL36 http://www.ncbi.nlm.nih.gov/gene/79786 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003270 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA KLHL8 http://www.ncbi.nlm.nih.gov/gene/57563 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003271 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA KRI1 http://www.ncbi.nlm.nih.gov/gene/65095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003272 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA LSM14B http://www.ncbi.nlm.nih.gov/gene/149986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003273 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA MAPK8 http://www.ncbi.nlm.nih.gov/gene/5599 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003274 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA MCL1 http://www.ncbi.nlm.nih.gov/gene/4170 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003275 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA MED13 http://www.ncbi.nlm.nih.gov/gene/9969 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003276 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA MEX3C http://www.ncbi.nlm.nih.gov/gene/51320 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003277 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA MKLN1 http://www.ncbi.nlm.nih.gov/gene/4289 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003278 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA MLLT3 http://www.ncbi.nlm.nih.gov/gene/4300 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003279 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA MOBKL1A http://www.ncbi.nlm.nih.gov/gene/92597 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003280 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA NAP1L5 http://www.ncbi.nlm.nih.gov/gene/266812 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003281 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA NBN http://www.ncbi.nlm.nih.gov/gene/4683 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003282 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA NDUFB2 http://www.ncbi.nlm.nih.gov/gene/4708 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003283 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA NKIRAS2 http://www.ncbi.nlm.nih.gov/gene/28511 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003284 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA NUDT19 http://www.ncbi.nlm.nih.gov/gene/390916 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003285 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA OXR1 http://www.ncbi.nlm.nih.gov/gene/55074 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003286 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA PAK2 http://www.ncbi.nlm.nih.gov/gene/5062 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003287 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA PCBP2 http://www.ncbi.nlm.nih.gov/gene/5094 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003288 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA PCYT1A http://www.ncbi.nlm.nih.gov/gene/5130 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003289 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA PDCD4 http://www.ncbi.nlm.nih.gov/gene/27250 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003290 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA PEX13 http://www.ncbi.nlm.nih.gov/gene/5194 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003291 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA PMAIP1 http://www.ncbi.nlm.nih.gov/gene/5366 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003292 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA PPM1A http://www.ncbi.nlm.nih.gov/gene/5494 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003293 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA PPP1CB http://www.ncbi.nlm.nih.gov/gene/245711 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003294 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA PPP2R5C http://www.ncbi.nlm.nih.gov/gene/5527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003295 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA PRDM4 http://www.ncbi.nlm.nih.gov/gene/11108 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003296 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA PURB http://www.ncbi.nlm.nih.gov/gene/5814 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003297 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA QTRTD1 http://www.ncbi.nlm.nih.gov/gene/79691 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003298 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA RBBP9 http://www.ncbi.nlm.nih.gov/gene/10741 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003299 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA RBL2 http://www.ncbi.nlm.nih.gov/gene/5934 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003300 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA RBM33 http://www.ncbi.nlm.nih.gov/gene/155435 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003301 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA RBM39 http://www.ncbi.nlm.nih.gov/gene/643167 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003302 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA RBM4B http://www.ncbi.nlm.nih.gov/gene/83759 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003303 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA REPIN1 http://www.ncbi.nlm.nih.gov/gene/29803 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003304 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA REST http://www.ncbi.nlm.nih.gov/gene/5978 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003305 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA RMND5A http://www.ncbi.nlm.nih.gov/gene/64795 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003306 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA RNMTL1 http://www.ncbi.nlm.nih.gov/gene/55178 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003307 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA ROCK1 http://www.ncbi.nlm.nih.gov/gene/727758 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003308 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA RPL36AL http://www.ncbi.nlm.nih.gov/gene/6166 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003309 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA SAR1A http://www.ncbi.nlm.nih.gov/gene/56681 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003310 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA SCOC http://www.ncbi.nlm.nih.gov/gene/60592 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003311 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA SENP1 http://www.ncbi.nlm.nih.gov/gene/29843 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003312 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA SETD6 http://www.ncbi.nlm.nih.gov/gene/79918 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003313 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA SFRS11 http://www.ncbi.nlm.nih.gov/gene/9295 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003314 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA SGPP1 http://www.ncbi.nlm.nih.gov/gene/81537 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003315 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA SLC19A2 http://www.ncbi.nlm.nih.gov/gene/10560 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003316 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA SLC30A9 http://www.ncbi.nlm.nih.gov/gene/10463 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003317 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA SLC44A5 http://www.ncbi.nlm.nih.gov/gene/204962 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003318 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA SNX29 http://www.ncbi.nlm.nih.gov/gene/92017 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003319 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA SP3 http://www.ncbi.nlm.nih.gov/gene/6670 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003320 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA STRN http://www.ncbi.nlm.nih.gov/gene/6801 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003321 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA TANC2 http://www.ncbi.nlm.nih.gov/gene/26115 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003322 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA TBC1D20 http://www.ncbi.nlm.nih.gov/gene/128637 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003323 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA TCF3 http://www.ncbi.nlm.nih.gov/gene/6929 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003324 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA TET3 http://www.ncbi.nlm.nih.gov/gene/200424 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003325 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA TGFBR3 http://www.ncbi.nlm.nih.gov/gene/7049 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003326 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA THUMPD1 http://www.ncbi.nlm.nih.gov/gene/55623 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003327 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA TIAL1 http://www.ncbi.nlm.nih.gov/gene/7073 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003328 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA TMED5 http://www.ncbi.nlm.nih.gov/gene/50999 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003329 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA TMEM129 http://www.ncbi.nlm.nih.gov/gene/92305 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003330 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA TMF1 http://www.ncbi.nlm.nih.gov/gene/7110 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003331 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA TOMM20 http://www.ncbi.nlm.nih.gov/gene/100129272 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003332 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA TOR1AIP1 http://www.ncbi.nlm.nih.gov/gene/26092 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003333 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA TP53INP1 http://www.ncbi.nlm.nih.gov/gene/94241 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003334 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA TRIT1 http://www.ncbi.nlm.nih.gov/gene/54802 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003335 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA UBE2L3 http://www.ncbi.nlm.nih.gov/gene/7332 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003336 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA UBE2W http://www.ncbi.nlm.nih.gov/gene/55284 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003337 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA UBQLN1 http://www.ncbi.nlm.nih.gov/gene/29979 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003338 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA UHRF1BP1 http://www.ncbi.nlm.nih.gov/gene/54887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003339 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA USP46 http://www.ncbi.nlm.nih.gov/gene/64854 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003340 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA USP53 http://www.ncbi.nlm.nih.gov/gene/54532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003341 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA VTA1 http://www.ncbi.nlm.nih.gov/gene/51534 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003342 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA WDR32 http://www.ncbi.nlm.nih.gov/gene/79269 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003343 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA ZBTB11 http://www.ncbi.nlm.nih.gov/gene/27107 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003344 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA ZDHHC11 http://www.ncbi.nlm.nih.gov/gene/79844 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003345 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA ZNF192 http://www.ncbi.nlm.nih.gov/gene/7745 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003346 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA ZNF330 http://www.ncbi.nlm.nih.gov/gene/27309 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003347 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA ZNF441 http://www.ncbi.nlm.nih.gov/gene/126068 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003348 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA ZNF518A http://www.ncbi.nlm.nih.gov/gene/9849 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003349 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA ZNF765 http://www.ncbi.nlm.nih.gov/gene/91661 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003350 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(ebv-mir-bart13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 BC-1 - Host mRNA ZNFX1 http://www.ncbi.nlm.nih.gov/gene/57169 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003351 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART13(mir-BART13) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003735 B cell lymphomagenesis - Host mRNA CAPRIN2 http://www.ncbi.nlm.nih.gov/gene/65981 - Western Blotting, Northern Blotting, Luciferase Reporter Assay. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VHID00003352 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA AAGAB http://www.ncbi.nlm.nih.gov/gene/79719 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003353 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA AASDHPPT http://www.ncbi.nlm.nih.gov/gene/60496 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003354 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ACOX1 http://www.ncbi.nlm.nih.gov/gene/51 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003355 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ACP1 http://www.ncbi.nlm.nih.gov/gene/52 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003356 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ACTL6A http://www.ncbi.nlm.nih.gov/gene/86 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003357 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA AFF4 http://www.ncbi.nlm.nih.gov/gene/27125 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003358 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA AKAP11 http://www.ncbi.nlm.nih.gov/gene/11215 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003359 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ANKRD13C http://www.ncbi.nlm.nih.gov/gene/81573 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003360 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ANP32E http://www.ncbi.nlm.nih.gov/gene/81611 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003361 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ARFGEF1 http://www.ncbi.nlm.nih.gov/gene/10565 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003362 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ARHGAP5 http://www.ncbi.nlm.nih.gov/gene/394 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003363 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ASZ1 http://www.ncbi.nlm.nih.gov/gene/136991 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003364 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ATF2 http://www.ncbi.nlm.nih.gov/gene/1386 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003365 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ATP2A2 http://www.ncbi.nlm.nih.gov/gene/488 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003366 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ATP6V1B2 http://www.ncbi.nlm.nih.gov/gene/526 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003367 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ATP6V1C1 http://www.ncbi.nlm.nih.gov/gene/528 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003368 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ATPAF1 http://www.ncbi.nlm.nih.gov/gene/64756 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003369 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ATXN1 http://www.ncbi.nlm.nih.gov/gene/6310 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003370 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA BAG2 http://www.ncbi.nlm.nih.gov/gene/9532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003371 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA BCL2 http://www.ncbi.nlm.nih.gov/gene/596 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003372 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA BNC2 http://www.ncbi.nlm.nih.gov/gene/54796 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003373 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA BRI3BP http://www.ncbi.nlm.nih.gov/gene/140707 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003374 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA BRWD1 http://www.ncbi.nlm.nih.gov/gene/54014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003375 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA BTBD1 http://www.ncbi.nlm.nih.gov/gene/53339 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003376 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA BTBD7 http://www.ncbi.nlm.nih.gov/gene/55727 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003377 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA C11orf30 http://www.ncbi.nlm.nih.gov/gene/56946 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003378 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA C12orf30 http://www.ncbi.nlm.nih.gov/gene/80018 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003379 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA C12orf5 http://www.ncbi.nlm.nih.gov/gene/57103 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003380 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA C12orf76 http://www.ncbi.nlm.nih.gov/gene/400073 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003381 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA C14orf126 http://www.ncbi.nlm.nih.gov/gene/112487 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003382 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA C14orf4 http://www.ncbi.nlm.nih.gov/gene/64207 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003383 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA C16orf28 http://www.ncbi.nlm.nih.gov/gene/64718 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003384 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA C18orf54 http://www.ncbi.nlm.nih.gov/gene/162681 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003385 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA C18orf55 http://www.ncbi.nlm.nih.gov/gene/29090 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003386 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA C19orf12 http://www.ncbi.nlm.nih.gov/gene/83636 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003387 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA C3orf64 http://www.ncbi.nlm.nih.gov/gene/285203 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003388 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA C4orf32 http://www.ncbi.nlm.nih.gov/gene/132720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003389 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA C5orf24 http://www.ncbi.nlm.nih.gov/gene/134553 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003390 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA C5orf41 http://www.ncbi.nlm.nih.gov/gene/153222 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003391 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA C5orf51 http://www.ncbi.nlm.nih.gov/gene/285636 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003392 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA C6orf167 http://www.ncbi.nlm.nih.gov/gene/253714 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003393 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA C6orf48 http://www.ncbi.nlm.nih.gov/gene/26797 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003394 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA C7orf60 http://www.ncbi.nlm.nih.gov/gene/154743 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003395 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA C8orf76 http://www.ncbi.nlm.nih.gov/gene/84933 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003396 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CALM1 http://www.ncbi.nlm.nih.gov/gene/808 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003397 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CAND1 http://www.ncbi.nlm.nih.gov/gene/55832 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003398 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CANX http://www.ncbi.nlm.nih.gov/gene/821 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003399 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CASC4 http://www.ncbi.nlm.nih.gov/gene/113201 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003400 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CASP6 http://www.ncbi.nlm.nih.gov/gene/839 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003401 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CAV1 http://www.ncbi.nlm.nih.gov/gene/857 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003402 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CBFA2T2 http://www.ncbi.nlm.nih.gov/gene/9139 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003403 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CBX5 http://www.ncbi.nlm.nih.gov/gene/23468 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003404 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CCNB1 http://www.ncbi.nlm.nih.gov/gene/891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003405 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CCND2 http://www.ncbi.nlm.nih.gov/gene/894 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003406 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CCNJ http://www.ncbi.nlm.nih.gov/gene/54619 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003407 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CENPL http://www.ncbi.nlm.nih.gov/gene/91687 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003408 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CFLAR http://www.ncbi.nlm.nih.gov/gene/8837 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003409 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CHST15 http://www.ncbi.nlm.nih.gov/gene/51363 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003410 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CLIC4 http://www.ncbi.nlm.nih.gov/gene/25932 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003411 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CLOCK http://www.ncbi.nlm.nih.gov/gene/9575 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003412 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CNBP http://www.ncbi.nlm.nih.gov/gene/7555 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003413 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA COMMD2 http://www.ncbi.nlm.nih.gov/gene/51122 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003414 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA COPS2 http://www.ncbi.nlm.nih.gov/gene/9318 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003415 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CPEB2 http://www.ncbi.nlm.nih.gov/gene/132864 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003416 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CPEB4 http://www.ncbi.nlm.nih.gov/gene/80315 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003417 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CPNE3 http://www.ncbi.nlm.nih.gov/gene/8895 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003418 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CPNE8 http://www.ncbi.nlm.nih.gov/gene/144402 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003419 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CPSF6 http://www.ncbi.nlm.nih.gov/gene/11052 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003420 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CSDE1 http://www.ncbi.nlm.nih.gov/gene/7812 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003421 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CSGALNACT2 http://www.ncbi.nlm.nih.gov/gene/55454 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003422 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA CSRP1 http://www.ncbi.nlm.nih.gov/gene/1465 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003423 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA DCLRE1B http://www.ncbi.nlm.nih.gov/gene/64858 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003424 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA DCP1A http://www.ncbi.nlm.nih.gov/gene/55802 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003425 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA DHCR7 http://www.ncbi.nlm.nih.gov/gene/1717 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003426 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA DHX8 http://www.ncbi.nlm.nih.gov/gene/1659 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003427 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA DIXDC1 http://www.ncbi.nlm.nih.gov/gene/85458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003428 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA DMXL1 http://www.ncbi.nlm.nih.gov/gene/1657 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003429 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA DNAJA1 http://www.ncbi.nlm.nih.gov/gene/3301 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003430 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA DUSP22 http://www.ncbi.nlm.nih.gov/gene/56940 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003431 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA DYNC1LI2 http://www.ncbi.nlm.nih.gov/gene/1783 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003432 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA E2F3 http://www.ncbi.nlm.nih.gov/gene/1871 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003433 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA E2F7 http://www.ncbi.nlm.nih.gov/gene/144455 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003434 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA EIF2C1 http://www.ncbi.nlm.nih.gov/gene/26523 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003435 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA EIF2C2 http://www.ncbi.nlm.nih.gov/gene/27161 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003436 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA EIF2S1 http://www.ncbi.nlm.nih.gov/gene/1965 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003437 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ELAVL1 http://www.ncbi.nlm.nih.gov/gene/1994 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003438 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ELK4 http://www.ncbi.nlm.nih.gov/gene/2005 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003439 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ERBB2IP http://www.ncbi.nlm.nih.gov/gene/55914 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003440 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA EXD2 http://www.ncbi.nlm.nih.gov/gene/55218 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003441 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA EXOC8 http://www.ncbi.nlm.nih.gov/gene/149371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003442 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA FAM117B http://www.ncbi.nlm.nih.gov/gene/150864 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003443 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA FAM126B http://www.ncbi.nlm.nih.gov/gene/285172 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003444 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA FAM172A http://www.ncbi.nlm.nih.gov/gene/83989 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003445 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA FAM73A http://www.ncbi.nlm.nih.gov/gene/374986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003446 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA FAM76B http://www.ncbi.nlm.nih.gov/gene/143684 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003447 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA FEM1C http://www.ncbi.nlm.nih.gov/gene/56929 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003448 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA FEZ2 http://www.ncbi.nlm.nih.gov/gene/9637 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003449 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA FNDC3A http://www.ncbi.nlm.nih.gov/gene/22862 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003450 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA FUNDC1 http://www.ncbi.nlm.nih.gov/gene/139341 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003451 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA FYCO1 http://www.ncbi.nlm.nih.gov/gene/79443 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003452 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA FZD6 http://www.ncbi.nlm.nih.gov/gene/8323 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003453 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA G3BP1 http://www.ncbi.nlm.nih.gov/gene/10146 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003454 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA GAB1 http://www.ncbi.nlm.nih.gov/gene/2549 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003455 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA GLT25D2 http://www.ncbi.nlm.nih.gov/gene/23127 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003456 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA GMEB2 http://www.ncbi.nlm.nih.gov/gene/26205 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003457 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA GNA13 http://www.ncbi.nlm.nih.gov/gene/10672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003458 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA GNL3L http://www.ncbi.nlm.nih.gov/gene/54552 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003459 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA GOPC http://www.ncbi.nlm.nih.gov/gene/57120 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003460 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA GRSF1 http://www.ncbi.nlm.nih.gov/gene/2926 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003461 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA H3F3B http://www.ncbi.nlm.nih.gov/gene/440926 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003462 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA HACE1 http://www.ncbi.nlm.nih.gov/gene/57531 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003463 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA HIAT1 http://www.ncbi.nlm.nih.gov/gene/64645 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003464 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA HIPK1 http://www.ncbi.nlm.nih.gov/gene/204851 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003465 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA HNRNPUL1 http://www.ncbi.nlm.nih.gov/gene/11100 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003466 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA HOMER1 http://www.ncbi.nlm.nih.gov/gene/9456 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003467 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA HOOK3 http://www.ncbi.nlm.nih.gov/gene/84376 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003468 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA HSPA4 http://www.ncbi.nlm.nih.gov/gene/3308 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003469 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA IDH3A http://www.ncbi.nlm.nih.gov/gene/3419 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003470 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA IGF2R http://www.ncbi.nlm.nih.gov/gene/3482 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003471 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA IL6ST http://www.ncbi.nlm.nih.gov/gene/3572 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003472 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA IMPAD1 http://www.ncbi.nlm.nih.gov/gene/54928 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003473 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA IQGAP1 http://www.ncbi.nlm.nih.gov/gene/8826 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003474 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA IRF1 http://www.ncbi.nlm.nih.gov/gene/3659 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003475 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ITM2A http://www.ncbi.nlm.nih.gov/gene/9452 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003476 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA JAKMIP2 http://www.ncbi.nlm.nih.gov/gene/9832 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003477 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA KCMF1 http://www.ncbi.nlm.nih.gov/gene/56888 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003478 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA KIAA0776 http://www.ncbi.nlm.nih.gov/gene/23376 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003479 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA KIAA1407 http://www.ncbi.nlm.nih.gov/gene/57577 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003480 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA KIAA1432 http://www.ncbi.nlm.nih.gov/gene/57589 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003481 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA KIAA2018 http://www.ncbi.nlm.nih.gov/gene/205717 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003482 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA KIF2A http://www.ncbi.nlm.nih.gov/gene/3796 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003483 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA KLHL15 http://www.ncbi.nlm.nih.gov/gene/80311 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003484 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA KLHL23 http://www.ncbi.nlm.nih.gov/gene/151230 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003485 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA KPNA5 http://www.ncbi.nlm.nih.gov/gene/3841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003486 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA KRAS http://www.ncbi.nlm.nih.gov/gene/3845 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003487 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA LAPTM4A http://www.ncbi.nlm.nih.gov/gene/9741 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003488 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA LARP4 http://www.ncbi.nlm.nih.gov/gene/113251 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003489 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA LATS1 http://www.ncbi.nlm.nih.gov/gene/9113 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003490 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA LCOR http://www.ncbi.nlm.nih.gov/gene/84458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003491 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA LEMD3 http://www.ncbi.nlm.nih.gov/gene/23592 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003492 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA LGR4 http://www.ncbi.nlm.nih.gov/gene/55366 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003493 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA LIN7C http://www.ncbi.nlm.nih.gov/gene/55327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003494 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA LMBR1 http://www.ncbi.nlm.nih.gov/gene/64327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003495 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA LRIG2 http://www.ncbi.nlm.nih.gov/gene/9860 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003496 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA LRRC58 http://www.ncbi.nlm.nih.gov/gene/116064 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003497 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA LZIC http://www.ncbi.nlm.nih.gov/gene/84328 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003498 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA MAK16 http://www.ncbi.nlm.nih.gov/gene/84549 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003499 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA MAL2 http://www.ncbi.nlm.nih.gov/gene/114569 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003500 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA MANEA http://www.ncbi.nlm.nih.gov/gene/79694 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003501 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA MDM4 http://www.ncbi.nlm.nih.gov/gene/4194 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003502 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA MED13 http://www.ncbi.nlm.nih.gov/gene/9969 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003503 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA MED13L http://www.ncbi.nlm.nih.gov/gene/23389 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003504 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA MIER1 http://www.ncbi.nlm.nih.gov/gene/57708 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003505 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA MIER3 http://www.ncbi.nlm.nih.gov/gene/166968 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003506 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA MKRN1 http://www.ncbi.nlm.nih.gov/gene/23608 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003507 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA MMGT1 http://www.ncbi.nlm.nih.gov/gene/93380 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003508 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA MTAP http://www.ncbi.nlm.nih.gov/gene/4507 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003509 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA MTDH http://www.ncbi.nlm.nih.gov/gene/92140 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003510 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA MTF2 http://www.ncbi.nlm.nih.gov/gene/22823 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003511 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA MTX3 http://www.ncbi.nlm.nih.gov/gene/345778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003512 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA MXD1 http://www.ncbi.nlm.nih.gov/gene/4084 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003513 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA NARS http://www.ncbi.nlm.nih.gov/gene/4677 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003514 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA NDEL1 http://www.ncbi.nlm.nih.gov/gene/81565 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003515 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA NDUFB5 http://www.ncbi.nlm.nih.gov/gene/4711 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003516 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA NDUFC1 http://www.ncbi.nlm.nih.gov/gene/4717 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003517 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA NFIA http://www.ncbi.nlm.nih.gov/gene/4774 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003518 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA NFYC http://www.ncbi.nlm.nih.gov/gene/4802 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003519 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA NHLRC2 http://www.ncbi.nlm.nih.gov/gene/374354 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003520 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA NHLRC3 http://www.ncbi.nlm.nih.gov/gene/387921 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003521 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA NIN http://www.ncbi.nlm.nih.gov/gene/51199 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003522 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA NLK http://www.ncbi.nlm.nih.gov/gene/51701 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003523 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA NOB1 http://www.ncbi.nlm.nih.gov/gene/100132364 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003524 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA NOM1 http://www.ncbi.nlm.nih.gov/gene/64434 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003525 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA NR1D2 http://www.ncbi.nlm.nih.gov/gene/9975 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003526 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA NSD1 http://www.ncbi.nlm.nih.gov/gene/64324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003527 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA NUCKS1 http://www.ncbi.nlm.nih.gov/gene/64710 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003528 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA NUFIP2 http://www.ncbi.nlm.nih.gov/gene/57532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003529 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA NUP54 http://www.ncbi.nlm.nih.gov/gene/53371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003530 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ORC2L http://www.ncbi.nlm.nih.gov/gene/4999 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003531 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA OSBPL8 http://www.ncbi.nlm.nih.gov/gene/114882 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003532 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA OSGIN2 http://www.ncbi.nlm.nih.gov/gene/734 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003533 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA OTUD7B http://www.ncbi.nlm.nih.gov/gene/56957 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003534 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PANK3 http://www.ncbi.nlm.nih.gov/gene/79646 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003535 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PCDH18 http://www.ncbi.nlm.nih.gov/gene/54510 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003536 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PCGF3 http://www.ncbi.nlm.nih.gov/gene/10336 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003537 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PDIK1L http://www.ncbi.nlm.nih.gov/gene/149420 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003538 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PDS5A http://www.ncbi.nlm.nih.gov/gene/23244 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003539 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PEX19 http://www.ncbi.nlm.nih.gov/gene/5824 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003540 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PGAP1 http://www.ncbi.nlm.nih.gov/gene/80055 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003541 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PGP http://www.ncbi.nlm.nih.gov/gene/283871 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003542 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PHC3 http://www.ncbi.nlm.nih.gov/gene/80012 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003543 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PHF10 http://www.ncbi.nlm.nih.gov/gene/55274 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003544 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PHLDA3 http://www.ncbi.nlm.nih.gov/gene/23612 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003545 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PIKFYVE http://www.ncbi.nlm.nih.gov/gene/200576 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003546 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PJA2 http://www.ncbi.nlm.nih.gov/gene/9867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003547 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PKN2 http://www.ncbi.nlm.nih.gov/gene/5586 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003548 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PLAG1 http://www.ncbi.nlm.nih.gov/gene/5324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003549 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PNN http://www.ncbi.nlm.nih.gov/gene/5411 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003550 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA POLH http://www.ncbi.nlm.nih.gov/gene/5429 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003551 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA POU2F1 http://www.ncbi.nlm.nih.gov/gene/5451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003552 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PPA1 http://www.ncbi.nlm.nih.gov/gene/5464 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003553 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PPAPDC2 http://www.ncbi.nlm.nih.gov/gene/403313 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003554 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PPARGC1B http://www.ncbi.nlm.nih.gov/gene/133522 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003555 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PPM1D http://www.ncbi.nlm.nih.gov/gene/8493 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003556 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PPPDE1 http://www.ncbi.nlm.nih.gov/gene/51029 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003557 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PQLC3 http://www.ncbi.nlm.nih.gov/gene/130814 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003558 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PREPL http://www.ncbi.nlm.nih.gov/gene/9581 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003559 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PRKAR1A http://www.ncbi.nlm.nih.gov/gene/5573 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003560 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PRPF40A http://www.ncbi.nlm.nih.gov/gene/55660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003561 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PTN http://www.ncbi.nlm.nih.gov/gene/5764 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003562 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PTPN2 http://www.ncbi.nlm.nih.gov/gene/5771 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003563 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PUM1 http://www.ncbi.nlm.nih.gov/gene/9698 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003564 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PURA http://www.ncbi.nlm.nih.gov/gene/5813 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003565 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA PURB http://www.ncbi.nlm.nih.gov/gene/5814 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003566 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA QKI http://www.ncbi.nlm.nih.gov/gene/9444 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003567 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RAB14 http://www.ncbi.nlm.nih.gov/gene/51552 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003568 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RAB22A http://www.ncbi.nlm.nih.gov/gene/57403 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003569 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RAB7L1 http://www.ncbi.nlm.nih.gov/gene/8934 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003570 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RABIF http://www.ncbi.nlm.nih.gov/gene/5877 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003571 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RAC1 http://www.ncbi.nlm.nih.gov/gene/5879 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003572 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RAD1 http://www.ncbi.nlm.nih.gov/gene/5810 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003573 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RAN http://www.ncbi.nlm.nih.gov/gene/5901 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003574 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RBM12B http://www.ncbi.nlm.nih.gov/gene/389677 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003575 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RBM26 http://www.ncbi.nlm.nih.gov/gene/64062 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003576 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RBPSUH http://www.ncbi.nlm.nih.gov/gene/3516 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003577 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RGS1 http://www.ncbi.nlm.nih.gov/gene/5996 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003578 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RIOK3 http://www.ncbi.nlm.nih.gov/gene/8780 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003579 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RNF38 http://www.ncbi.nlm.nih.gov/gene/152006 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003580 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RNF44 http://www.ncbi.nlm.nih.gov/gene/22838 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003581 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RNMT http://www.ncbi.nlm.nih.gov/gene/8731 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003582 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RORA http://www.ncbi.nlm.nih.gov/gene/6095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003583 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RPP14 http://www.ncbi.nlm.nih.gov/gene/11102 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003584 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RPRD1A http://www.ncbi.nlm.nih.gov/gene/55197 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003585 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RPRD2 http://www.ncbi.nlm.nih.gov/gene/23248 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003586 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RRM2B http://www.ncbi.nlm.nih.gov/gene/50484 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003587 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RTF1 http://www.ncbi.nlm.nih.gov/gene/23168 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003588 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA RUNX2 http://www.ncbi.nlm.nih.gov/gene/860 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003589 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SAMD9 http://www.ncbi.nlm.nih.gov/gene/54809 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003590 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SCAMP1 http://www.ncbi.nlm.nih.gov/gene/9522 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003591 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SCP2 http://www.ncbi.nlm.nih.gov/gene/6342 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003592 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SCYL2 http://www.ncbi.nlm.nih.gov/gene/55681 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003593 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SECISBP2L http://www.ncbi.nlm.nih.gov/gene/9728 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003594 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SENP6 http://www.ncbi.nlm.nih.gov/gene/26054 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003595 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SEPSECS http://www.ncbi.nlm.nih.gov/gene/51091 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003596 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SERINC3 http://www.ncbi.nlm.nih.gov/gene/10955 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003597 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SETD7 http://www.ncbi.nlm.nih.gov/gene/80854 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003598 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SH3PXD2A http://www.ncbi.nlm.nih.gov/gene/9644 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003599 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SIKE1 http://www.ncbi.nlm.nih.gov/gene/80143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003600 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SIN3A http://www.ncbi.nlm.nih.gov/gene/25942 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003601 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SLC11A2 http://www.ncbi.nlm.nih.gov/gene/4891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003602 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SLC16A1 http://www.ncbi.nlm.nih.gov/gene/6566 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003603 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SLC23A2 http://www.ncbi.nlm.nih.gov/gene/9962 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003604 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SLC25A12 http://www.ncbi.nlm.nih.gov/gene/8604 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003605 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SLC25A36 http://www.ncbi.nlm.nih.gov/gene/55186 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003606 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SLC25A44 http://www.ncbi.nlm.nih.gov/gene/9673 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003607 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SLC25A46 http://www.ncbi.nlm.nih.gov/gene/91137 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003608 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SLC30A9 http://www.ncbi.nlm.nih.gov/gene/10463 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003609 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SLC38A1 http://www.ncbi.nlm.nih.gov/gene/81539 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003610 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SLMO2 http://www.ncbi.nlm.nih.gov/gene/51012 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003611 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SLTM http://www.ncbi.nlm.nih.gov/gene/79811 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003612 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SNRNP200 http://www.ncbi.nlm.nih.gov/gene/652147 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003613 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SNX10 http://www.ncbi.nlm.nih.gov/gene/29887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003614 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SNX13 http://www.ncbi.nlm.nih.gov/gene/23161 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003615 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SNX18 http://www.ncbi.nlm.nih.gov/gene/112574 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003616 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SOCS4 http://www.ncbi.nlm.nih.gov/gene/122809 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003617 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SOS1 http://www.ncbi.nlm.nih.gov/gene/6654 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003618 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SPCS3 http://www.ncbi.nlm.nih.gov/gene/60559 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003619 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SPG20 http://www.ncbi.nlm.nih.gov/gene/23111 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003620 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SRPK1 http://www.ncbi.nlm.nih.gov/gene/6732 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003621 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SSFA2 http://www.ncbi.nlm.nih.gov/gene/6744 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003622 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SSH2 http://www.ncbi.nlm.nih.gov/gene/85464 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003623 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA STIM2 http://www.ncbi.nlm.nih.gov/gene/57620 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003624 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA STK35 http://www.ncbi.nlm.nih.gov/gene/140901 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003625 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA STK38L http://www.ncbi.nlm.nih.gov/gene/23012 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003626 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA STYX http://www.ncbi.nlm.nih.gov/gene/6815 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003627 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SYF2 http://www.ncbi.nlm.nih.gov/gene/25949 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003628 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA SYT1 http://www.ncbi.nlm.nih.gov/gene/6857 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003629 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA TACC1 http://www.ncbi.nlm.nih.gov/gene/6867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003630 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA TADA1L http://www.ncbi.nlm.nih.gov/gene/117143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003631 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA TAF2 http://www.ncbi.nlm.nih.gov/gene/6873 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003632 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA TBRG1 http://www.ncbi.nlm.nih.gov/gene/84897 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003633 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA TCF12 http://www.ncbi.nlm.nih.gov/gene/6938 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003634 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA TEX261 http://www.ncbi.nlm.nih.gov/gene/113419 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003635 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA TGFBR3 http://www.ncbi.nlm.nih.gov/gene/7049 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003636 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA TK2 http://www.ncbi.nlm.nih.gov/gene/7084 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003637 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA TMEM117 http://www.ncbi.nlm.nih.gov/gene/84216 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003638 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA TMTC3 http://www.ncbi.nlm.nih.gov/gene/160418 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003639 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA TMTC4 http://www.ncbi.nlm.nih.gov/gene/84899 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003640 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA TNKS1BP1 http://www.ncbi.nlm.nih.gov/gene/85456 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003641 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA TNRC6B http://www.ncbi.nlm.nih.gov/gene/23112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003642 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA TP53INP1 http://www.ncbi.nlm.nih.gov/gene/94241 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003643 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA TPD52 http://www.ncbi.nlm.nih.gov/gene/7163 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003644 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA TPM4 http://www.ncbi.nlm.nih.gov/gene/7171 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003645 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA TRIM23 http://www.ncbi.nlm.nih.gov/gene/373 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003646 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA TRIM65 http://www.ncbi.nlm.nih.gov/gene/201292 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003647 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA TRIM68 http://www.ncbi.nlm.nih.gov/gene/55128 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003648 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA TRUB1 http://www.ncbi.nlm.nih.gov/gene/142940 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003649 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA TUSC2 http://www.ncbi.nlm.nih.gov/gene/11334 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003650 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA UBE2A http://www.ncbi.nlm.nih.gov/gene/7319 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003651 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA UBE2D3 http://www.ncbi.nlm.nih.gov/gene/100037280 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003652 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA UBE2N http://www.ncbi.nlm.nih.gov/gene/7334 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003653 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA UBE2V2 http://www.ncbi.nlm.nih.gov/gene/7336 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003654 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA UBP1 http://www.ncbi.nlm.nih.gov/gene/7342 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003655 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA UGT8 http://www.ncbi.nlm.nih.gov/gene/7368 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003656 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA UHMK1 http://www.ncbi.nlm.nih.gov/gene/127933 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003657 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA USP34 http://www.ncbi.nlm.nih.gov/gene/9736 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003658 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA USP37 http://www.ncbi.nlm.nih.gov/gene/57695 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003659 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA VHL http://www.ncbi.nlm.nih.gov/gene/7428 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003660 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA VPS41 http://www.ncbi.nlm.nih.gov/gene/27072 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003661 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA WDR26 http://www.ncbi.nlm.nih.gov/gene/80232 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003662 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA WDR60 http://www.ncbi.nlm.nih.gov/gene/55112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003663 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA WNK1 http://www.ncbi.nlm.nih.gov/gene/65125 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003664 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA WWTR1 http://www.ncbi.nlm.nih.gov/gene/25937 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003665 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA XPO1 http://www.ncbi.nlm.nih.gov/gene/7514 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003666 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA YIPF4 http://www.ncbi.nlm.nih.gov/gene/84272 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003667 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA YPEL5 http://www.ncbi.nlm.nih.gov/gene/51646 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003668 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA YTHDF1 http://www.ncbi.nlm.nih.gov/gene/54915 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003669 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZBTB10 http://www.ncbi.nlm.nih.gov/gene/65986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003670 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZBTB11 http://www.ncbi.nlm.nih.gov/gene/27107 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003671 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZBTB38 http://www.ncbi.nlm.nih.gov/gene/253461 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003672 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZBTB7B http://www.ncbi.nlm.nih.gov/gene/51043 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003673 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZC3H6 http://www.ncbi.nlm.nih.gov/gene/376940 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003674 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZDHHC17 http://www.ncbi.nlm.nih.gov/gene/23390 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003675 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZFP91 http://www.ncbi.nlm.nih.gov/gene/386607 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003676 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZKSCAN5 http://www.ncbi.nlm.nih.gov/gene/23660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003677 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZMPSTE24 http://www.ncbi.nlm.nih.gov/gene/10269 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003678 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZNF184 http://www.ncbi.nlm.nih.gov/gene/7738 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003679 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZNF254 http://www.ncbi.nlm.nih.gov/gene/9534 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003680 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZNF264 http://www.ncbi.nlm.nih.gov/gene/9422 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003681 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZNF354A http://www.ncbi.nlm.nih.gov/gene/6940 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003682 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZNF516 http://www.ncbi.nlm.nih.gov/gene/9658 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003683 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZNF518A http://www.ncbi.nlm.nih.gov/gene/9849 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003684 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZNF624 http://www.ncbi.nlm.nih.gov/gene/57547 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003685 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZNF652 http://www.ncbi.nlm.nih.gov/gene/22834 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003686 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZNF714 http://www.ncbi.nlm.nih.gov/gene/148206 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003687 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZNF721 http://www.ncbi.nlm.nih.gov/gene/170960 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003688 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZNF827 http://www.ncbi.nlm.nih.gov/gene/152485 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003689 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZNF83 http://www.ncbi.nlm.nih.gov/gene/55769 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003690 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART14(ebv-mir-bart14) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003736 BC-1 - Host mRNA ZNF91 http://www.ncbi.nlm.nih.gov/gene/7644 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003691 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA KPNA1 http://www.ncbi.nlm.nih.gov/gene/3836 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs. VHID00003692 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ABCB7 http://www.ncbi.nlm.nih.gov/gene/22 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003693 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ACSL1 http://www.ncbi.nlm.nih.gov/gene/2180 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003694 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ADAM10 http://www.ncbi.nlm.nih.gov/gene/102 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003695 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA AFF1 http://www.ncbi.nlm.nih.gov/gene/4299 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003696 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ALS2 http://www.ncbi.nlm.nih.gov/gene/57679 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003697 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ANKRD52 http://www.ncbi.nlm.nih.gov/gene/283373 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003698 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ANO3 http://www.ncbi.nlm.nih.gov/gene/63982 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003699 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA APLP2 http://www.ncbi.nlm.nih.gov/gene/334 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003700 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ARID3A http://www.ncbi.nlm.nih.gov/gene/1820 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003701 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ATP6AP2 http://www.ncbi.nlm.nih.gov/gene/10159 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003702 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ATP6V1A http://www.ncbi.nlm.nih.gov/gene/523 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003703 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ATXN1L http://www.ncbi.nlm.nih.gov/gene/342371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003704 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA B4GALT5 http://www.ncbi.nlm.nih.gov/gene/9334 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003705 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA B4GALT6 http://www.ncbi.nlm.nih.gov/gene/9331 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003706 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA BAZ2B http://www.ncbi.nlm.nih.gov/gene/29994 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003707 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA BCL7B http://www.ncbi.nlm.nih.gov/gene/9275 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003708 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA BRMS1L http://www.ncbi.nlm.nih.gov/gene/84312 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003709 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA BTBD3 http://www.ncbi.nlm.nih.gov/gene/22903 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003710 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA BTN3A1 http://www.ncbi.nlm.nih.gov/gene/11119 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003711 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA BTN3A2 http://www.ncbi.nlm.nih.gov/gene/11118 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003712 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA C10orf104 http://www.ncbi.nlm.nih.gov/gene/119504 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003713 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA C11orf57 http://www.ncbi.nlm.nih.gov/gene/55216 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003714 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA C20orf112 http://www.ncbi.nlm.nih.gov/gene/140688 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003715 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA C22orf40 http://www.ncbi.nlm.nih.gov/gene/150383 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003716 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA C3orf64 http://www.ncbi.nlm.nih.gov/gene/285203 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003717 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA C5orf30 http://www.ncbi.nlm.nih.gov/gene/90355 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003718 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA C6orf120 http://www.ncbi.nlm.nih.gov/gene/387263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003719 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA C6orf62 http://www.ncbi.nlm.nih.gov/gene/81688 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003720 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA C7orf60 http://www.ncbi.nlm.nih.gov/gene/154743 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003721 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA C9orf6 http://www.ncbi.nlm.nih.gov/gene/54942 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003722 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA CAND1 http://www.ncbi.nlm.nih.gov/gene/55832 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003723 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA CANX http://www.ncbi.nlm.nih.gov/gene/821 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003724 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA CARD16 http://www.ncbi.nlm.nih.gov/gene/114769 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003725 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA CARHSP1 http://www.ncbi.nlm.nih.gov/gene/23589 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003726 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA CBFA2T2 http://www.ncbi.nlm.nih.gov/gene/9139 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003727 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA CCND2 http://www.ncbi.nlm.nih.gov/gene/894 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003728 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA CCT6A http://www.ncbi.nlm.nih.gov/gene/908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003729 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA CD164 http://www.ncbi.nlm.nih.gov/gene/8763 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003730 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA CD46 http://www.ncbi.nlm.nih.gov/gene/4179 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003731 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA CDC2L6 http://www.ncbi.nlm.nih.gov/gene/23097 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003732 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA CDKN1B http://www.ncbi.nlm.nih.gov/gene/1027 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003733 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA CHD2 http://www.ncbi.nlm.nih.gov/gene/1106 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003734 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA CHUK http://www.ncbi.nlm.nih.gov/gene/1147 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003735 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA COBLL1 http://www.ncbi.nlm.nih.gov/gene/22837 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003736 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA CRCP http://www.ncbi.nlm.nih.gov/gene/27297 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003737 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA CREG1 http://www.ncbi.nlm.nih.gov/gene/8804 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003738 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA CRIPT http://www.ncbi.nlm.nih.gov/gene/9419 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003739 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA CRTC3 http://www.ncbi.nlm.nih.gov/gene/64784 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003740 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA CSGALNACT2 http://www.ncbi.nlm.nih.gov/gene/55454 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003741 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA CYTH3 http://www.ncbi.nlm.nih.gov/gene/9265 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003742 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA DDX31 http://www.ncbi.nlm.nih.gov/gene/64794 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003743 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA DDX3X http://www.ncbi.nlm.nih.gov/gene/1654 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003744 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA DEPDC1 http://www.ncbi.nlm.nih.gov/gene/55635 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003745 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA DICER1 http://www.ncbi.nlm.nih.gov/gene/23405 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003746 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA DSTYK http://www.ncbi.nlm.nih.gov/gene/25778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003747 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA DYRK1A http://www.ncbi.nlm.nih.gov/gene/1859 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003748 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA EIF2S3 http://www.ncbi.nlm.nih.gov/gene/1968 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003749 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ELL http://www.ncbi.nlm.nih.gov/gene/8178 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003750 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA EPDR1 http://www.ncbi.nlm.nih.gov/gene/54749 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003751 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA EPS15 http://www.ncbi.nlm.nih.gov/gene/2060 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003752 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA EVI5 http://www.ncbi.nlm.nih.gov/gene/7813 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003753 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA EYA4 http://www.ncbi.nlm.nih.gov/gene/2070 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003754 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA FAM107B http://www.ncbi.nlm.nih.gov/gene/83641 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003755 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA FAM108B1 http://www.ncbi.nlm.nih.gov/gene/51104 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003756 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA FAM159B http://www.ncbi.nlm.nih.gov/gene/285672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003757 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA FEM1C http://www.ncbi.nlm.nih.gov/gene/56929 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003758 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA FOXN2 http://www.ncbi.nlm.nih.gov/gene/3344 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003759 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA FXR1 http://www.ncbi.nlm.nih.gov/gene/8087 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003760 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA FZD6 http://www.ncbi.nlm.nih.gov/gene/8323 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003761 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA GALK2 http://www.ncbi.nlm.nih.gov/gene/2585 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003762 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA GOLT1B http://www.ncbi.nlm.nih.gov/gene/51026 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003763 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA GPATCH8 http://www.ncbi.nlm.nih.gov/gene/23131 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003764 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA GPD1L http://www.ncbi.nlm.nih.gov/gene/23171 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003765 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA HAT1 http://www.ncbi.nlm.nih.gov/gene/8520 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003766 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA HDGF http://www.ncbi.nlm.nih.gov/gene/3068 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003767 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA HOXB7 http://www.ncbi.nlm.nih.gov/gene/3217 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003768 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA HSPA13 http://www.ncbi.nlm.nih.gov/gene/6782 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003769 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA HSPE1 http://www.ncbi.nlm.nih.gov/gene/3336 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003770 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA IFT74 http://www.ncbi.nlm.nih.gov/gene/80173 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003771 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA IKZF3 http://www.ncbi.nlm.nih.gov/gene/22806 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003772 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA INSIG1 http://www.ncbi.nlm.nih.gov/gene/3638 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003773 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA IPO7 http://www.ncbi.nlm.nih.gov/gene/10527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003774 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA IQCE http://www.ncbi.nlm.nih.gov/gene/23288 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003775 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ITSN2 http://www.ncbi.nlm.nih.gov/gene/50618 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003776 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA JARID2 http://www.ncbi.nlm.nih.gov/gene/3720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003777 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA KIAA0317 http://www.ncbi.nlm.nih.gov/gene/9870 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003778 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA KIAA1328 http://www.ncbi.nlm.nih.gov/gene/57536 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003779 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA KIF1B http://www.ncbi.nlm.nih.gov/gene/23095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003780 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA KLHL23 http://www.ncbi.nlm.nih.gov/gene/151230 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003781 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA KPNA1 http://www.ncbi.nlm.nih.gov/gene/3836 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003782 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA KRAS http://www.ncbi.nlm.nih.gov/gene/3845 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003783 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA LANCL1 http://www.ncbi.nlm.nih.gov/gene/10314 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003784 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA LIMD1 http://www.ncbi.nlm.nih.gov/gene/8994 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003785 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA LMBR1 http://www.ncbi.nlm.nih.gov/gene/64327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003786 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA LMNB1 http://www.ncbi.nlm.nih.gov/gene/4001 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003787 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA LYPLAL1 http://www.ncbi.nlm.nih.gov/gene/127018 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003788 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA LZTR1 http://www.ncbi.nlm.nih.gov/gene/8216 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003789 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA MAP3K7 http://www.ncbi.nlm.nih.gov/gene/6885 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003790 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA MAPK1IP1L http://www.ncbi.nlm.nih.gov/gene/93487 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003791 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA MFN2 http://www.ncbi.nlm.nih.gov/gene/9927 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003792 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA MFSD6 http://www.ncbi.nlm.nih.gov/gene/54842 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003793 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA MLL3 http://www.ncbi.nlm.nih.gov/gene/58508 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003794 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA MNT http://www.ncbi.nlm.nih.gov/gene/4335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003795 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA MTCH2 http://www.ncbi.nlm.nih.gov/gene/23788 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003796 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA MTPN http://www.ncbi.nlm.nih.gov/gene/767558 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003797 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA MYNN http://www.ncbi.nlm.nih.gov/gene/55892 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003798 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA NASP http://www.ncbi.nlm.nih.gov/gene/4678 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003799 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA NDUFA10 http://www.ncbi.nlm.nih.gov/gene/4705 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003800 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA NME1 http://www.ncbi.nlm.nih.gov/gene/4831 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003801 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA NPTN http://www.ncbi.nlm.nih.gov/gene/27020 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003802 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA NR1D2 http://www.ncbi.nlm.nih.gov/gene/9975 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003803 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA NSFL1C http://www.ncbi.nlm.nih.gov/gene/55968 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003804 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA NUFIP2 http://www.ncbi.nlm.nih.gov/gene/57532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003805 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ORC2L http://www.ncbi.nlm.nih.gov/gene/4999 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003806 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA OSBPL8 http://www.ncbi.nlm.nih.gov/gene/114882 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003807 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA PANK3 http://www.ncbi.nlm.nih.gov/gene/79646 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003808 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA PAPD5 http://www.ncbi.nlm.nih.gov/gene/64282 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003809 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA PCNX http://www.ncbi.nlm.nih.gov/gene/22990 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003810 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA PDCD10 http://www.ncbi.nlm.nih.gov/gene/11235 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003811 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA PDCD7 http://www.ncbi.nlm.nih.gov/gene/10081 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003812 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA PFKM http://www.ncbi.nlm.nih.gov/gene/5213 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003813 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA PLAG1 http://www.ncbi.nlm.nih.gov/gene/5324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003814 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA POLR2J http://www.ncbi.nlm.nih.gov/gene/5439 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003815 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA PPAPDC2 http://www.ncbi.nlm.nih.gov/gene/403313 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003816 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA PPARD http://www.ncbi.nlm.nih.gov/gene/5467 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003817 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA PPP1R12A http://www.ncbi.nlm.nih.gov/gene/4659 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003818 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA PRKAA1 http://www.ncbi.nlm.nih.gov/gene/5562 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003819 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA PRNP http://www.ncbi.nlm.nih.gov/gene/5621 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003820 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA PRPF40A http://www.ncbi.nlm.nih.gov/gene/55660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003821 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA PTCD2 http://www.ncbi.nlm.nih.gov/gene/79810 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003822 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA PTPLAD1 http://www.ncbi.nlm.nih.gov/gene/51495 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003823 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA QARS http://www.ncbi.nlm.nih.gov/gene/5859 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003824 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA RC3H1 http://www.ncbi.nlm.nih.gov/gene/149041 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003825 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA REEP5 http://www.ncbi.nlm.nih.gov/gene/7905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003826 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA RNF138 http://www.ncbi.nlm.nih.gov/gene/51444 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003827 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA RNF141 http://www.ncbi.nlm.nih.gov/gene/50862 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003828 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA RORA http://www.ncbi.nlm.nih.gov/gene/6095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003829 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA RPS6KA3 http://www.ncbi.nlm.nih.gov/gene/6197 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003830 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA RPS6KB1 http://www.ncbi.nlm.nih.gov/gene/6198 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003831 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA RSAD1 http://www.ncbi.nlm.nih.gov/gene/55316 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003832 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA SBF2 http://www.ncbi.nlm.nih.gov/gene/81846 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003833 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA SEC61A1 http://www.ncbi.nlm.nih.gov/gene/29927 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003834 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA SESTD1 http://www.ncbi.nlm.nih.gov/gene/91404 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003835 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA SFPQ http://www.ncbi.nlm.nih.gov/gene/6421 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003836 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA SFXN1 http://www.ncbi.nlm.nih.gov/gene/94081 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003837 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA SGK3 http://www.ncbi.nlm.nih.gov/gene/23678 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003838 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA SH3BP2 http://www.ncbi.nlm.nih.gov/gene/6452 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003839 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA SIAH1 http://www.ncbi.nlm.nih.gov/gene/6477 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003840 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA SIK2 http://www.ncbi.nlm.nih.gov/gene/23235 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003841 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA SIRT3 http://www.ncbi.nlm.nih.gov/gene/23410 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003842 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA SLC7A5 http://www.ncbi.nlm.nih.gov/gene/8140 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003843 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA SMC6 http://www.ncbi.nlm.nih.gov/gene/79677 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003844 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA SMG7 http://www.ncbi.nlm.nih.gov/gene/9887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003845 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA SNX11 http://www.ncbi.nlm.nih.gov/gene/29916 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003846 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA SOCS6 http://www.ncbi.nlm.nih.gov/gene/9306 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003847 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA SOX5 http://www.ncbi.nlm.nih.gov/gene/6660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003848 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA SP1 http://www.ncbi.nlm.nih.gov/gene/6667 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003849 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA SP3 http://www.ncbi.nlm.nih.gov/gene/6670 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003850 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA SS18L1 http://www.ncbi.nlm.nih.gov/gene/26039 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003851 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA STK38L http://www.ncbi.nlm.nih.gov/gene/23012 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003852 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA STYX http://www.ncbi.nlm.nih.gov/gene/6815 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003853 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA SVIP http://www.ncbi.nlm.nih.gov/gene/258010 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003854 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA TBL1XR1 http://www.ncbi.nlm.nih.gov/gene/79718 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003855 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA TCF4 http://www.ncbi.nlm.nih.gov/gene/6925 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003856 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA TCP11L1 http://www.ncbi.nlm.nih.gov/gene/55346 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003857 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA TGFBRAP1 http://www.ncbi.nlm.nih.gov/gene/9392 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003858 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA TGOLN2 http://www.ncbi.nlm.nih.gov/gene/10618 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003859 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA THAP11 http://www.ncbi.nlm.nih.gov/gene/57215 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003860 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA TM7SF3 http://www.ncbi.nlm.nih.gov/gene/51768 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003861 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA TMEM214 http://www.ncbi.nlm.nih.gov/gene/54867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003862 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA TMTC3 http://www.ncbi.nlm.nih.gov/gene/160418 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003863 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA TNKS2 http://www.ncbi.nlm.nih.gov/gene/80351 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003864 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA TNRC6A http://www.ncbi.nlm.nih.gov/gene/27327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003865 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA TNRC6C http://www.ncbi.nlm.nih.gov/gene/57690 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003866 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA TP53RK http://www.ncbi.nlm.nih.gov/gene/112858 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003867 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA TSC22D3 http://www.ncbi.nlm.nih.gov/gene/23151 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003868 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA TTC32 http://www.ncbi.nlm.nih.gov/gene/130502 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003869 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA UBE2D3 http://www.ncbi.nlm.nih.gov/gene/100037280 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003870 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA UBXN4 http://www.ncbi.nlm.nih.gov/gene/23190 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003871 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA UHRF1BP1 http://www.ncbi.nlm.nih.gov/gene/54887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003872 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA USPL1 http://www.ncbi.nlm.nih.gov/gene/10208 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003873 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA WDR37 http://www.ncbi.nlm.nih.gov/gene/22884 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003874 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA YWHAG http://www.ncbi.nlm.nih.gov/gene/7532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003875 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ZBTB11 http://www.ncbi.nlm.nih.gov/gene/27107 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003876 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ZBTB38 http://www.ncbi.nlm.nih.gov/gene/253461 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003877 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ZBTB6 http://www.ncbi.nlm.nih.gov/gene/10773 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003878 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ZFYVE26 http://www.ncbi.nlm.nih.gov/gene/23503 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003879 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ZNF136 http://www.ncbi.nlm.nih.gov/gene/7695 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003880 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ZNF264 http://www.ncbi.nlm.nih.gov/gene/9422 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003881 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ZNF367 http://www.ncbi.nlm.nih.gov/gene/195828 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003882 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ZNF460 http://www.ncbi.nlm.nih.gov/gene/10794 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003883 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ZNF498 http://www.ncbi.nlm.nih.gov/gene/221785 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003884 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ZNF776 http://www.ncbi.nlm.nih.gov/gene/284309 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003885 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ZNF804A http://www.ncbi.nlm.nih.gov/gene/91752 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003886 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 BC-1 - Host mRNA ZSCAN29 http://www.ncbi.nlm.nih.gov/gene/146050 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003887 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA AFF1 http://www.ncbi.nlm.nih.gov/gene/4299 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003888 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA AHCYL1 http://www.ncbi.nlm.nih.gov/gene/10768 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003889 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA ALS2 http://www.ncbi.nlm.nih.gov/gene/57679 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003890 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA AP3B1 http://www.ncbi.nlm.nih.gov/gene/8546 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003891 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA ARID3A http://www.ncbi.nlm.nih.gov/gene/1820 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003892 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA ARL4C http://www.ncbi.nlm.nih.gov/gene/10123 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003893 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA B2M http://www.ncbi.nlm.nih.gov/gene/567 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003894 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA B4GALT6 http://www.ncbi.nlm.nih.gov/gene/9331 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003895 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA BAZ2B http://www.ncbi.nlm.nih.gov/gene/29994 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003896 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA BBS7 http://www.ncbi.nlm.nih.gov/gene/55212 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003897 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA BTBD3 http://www.ncbi.nlm.nih.gov/gene/22903 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003898 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA C10orf104 http://www.ncbi.nlm.nih.gov/gene/119504 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003899 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA C6orf120 http://www.ncbi.nlm.nih.gov/gene/387263 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003900 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA CANX http://www.ncbi.nlm.nih.gov/gene/821 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003901 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA CBX5 http://www.ncbi.nlm.nih.gov/gene/23468 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003902 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA CCNYL1 http://www.ncbi.nlm.nih.gov/gene/151195 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003903 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA CDKN1B http://www.ncbi.nlm.nih.gov/gene/1027 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003904 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA CHUK http://www.ncbi.nlm.nih.gov/gene/1147 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003905 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA CRIPT http://www.ncbi.nlm.nih.gov/gene/9419 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003906 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA DAP http://www.ncbi.nlm.nih.gov/gene/1611 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003907 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA DDX31 http://www.ncbi.nlm.nih.gov/gene/64794 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003908 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA DDX3X http://www.ncbi.nlm.nih.gov/gene/1654 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003909 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA DICER1 http://www.ncbi.nlm.nih.gov/gene/23405 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003910 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA DMD http://www.ncbi.nlm.nih.gov/gene/1756 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003911 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA DSTYK http://www.ncbi.nlm.nih.gov/gene/25778 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003912 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA EIF2S3 http://www.ncbi.nlm.nih.gov/gene/1968 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003913 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA ELL http://www.ncbi.nlm.nih.gov/gene/8178 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003914 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA EPS15 http://www.ncbi.nlm.nih.gov/gene/2060 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003915 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA FADS1 http://www.ncbi.nlm.nih.gov/gene/3992 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003916 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA FXR1 http://www.ncbi.nlm.nih.gov/gene/8087 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003917 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA GALK2 http://www.ncbi.nlm.nih.gov/gene/2585 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003918 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA GDI1 http://www.ncbi.nlm.nih.gov/gene/2664 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003919 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA GPATCH8 http://www.ncbi.nlm.nih.gov/gene/23131 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003920 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA HECTD1 http://www.ncbi.nlm.nih.gov/gene/25831 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003921 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA HLA-DRA http://www.ncbi.nlm.nih.gov/gene/3122 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003922 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA HSPH1 http://www.ncbi.nlm.nih.gov/gene/10808 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003923 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA IARS http://www.ncbi.nlm.nih.gov/gene/3376 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003924 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA INSIG1 http://www.ncbi.nlm.nih.gov/gene/3638 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003925 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA ITSN2 http://www.ncbi.nlm.nih.gov/gene/50618 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003926 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA KIAA1370 http://www.ncbi.nlm.nih.gov/gene/56204 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003927 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA KIAA2018 http://www.ncbi.nlm.nih.gov/gene/205717 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003928 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA KRAS http://www.ncbi.nlm.nih.gov/gene/3845 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003929 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA LMBR1 http://www.ncbi.nlm.nih.gov/gene/64327 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003930 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA LMNB1 http://www.ncbi.nlm.nih.gov/gene/4001 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003931 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA MGLL http://www.ncbi.nlm.nih.gov/gene/11343 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003932 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA NAT12 http://www.ncbi.nlm.nih.gov/gene/122830 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003933 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA NFKBID http://www.ncbi.nlm.nih.gov/gene/84807 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003934 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA NPTN http://www.ncbi.nlm.nih.gov/gene/27020 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003935 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA NUFIP2 http://www.ncbi.nlm.nih.gov/gene/57532 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003936 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA NUP155 http://www.ncbi.nlm.nih.gov/gene/9631 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003937 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA NUSAP1 http://www.ncbi.nlm.nih.gov/gene/51203 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003938 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA OXSR1 http://www.ncbi.nlm.nih.gov/gene/9943 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003939 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA PCNX http://www.ncbi.nlm.nih.gov/gene/22990 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003940 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA PLAG1 http://www.ncbi.nlm.nih.gov/gene/5324 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003941 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA POLR3D http://www.ncbi.nlm.nih.gov/gene/661 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003942 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA PPARD http://www.ncbi.nlm.nih.gov/gene/5467 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003943 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA PRKAA1 http://www.ncbi.nlm.nih.gov/gene/5562 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003944 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA PTAR1 http://www.ncbi.nlm.nih.gov/gene/375743 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003945 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA RASGRP3 http://www.ncbi.nlm.nih.gov/gene/25780 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003946 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA RB1 http://www.ncbi.nlm.nih.gov/gene/5925 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003947 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA RBM38 http://www.ncbi.nlm.nih.gov/gene/55544 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003948 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA RPAP2 http://www.ncbi.nlm.nih.gov/gene/79871 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003949 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA RPS6KA3 http://www.ncbi.nlm.nih.gov/gene/6197 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003950 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA SAMD12 http://www.ncbi.nlm.nih.gov/gene/401474 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003951 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA SESTD1 http://www.ncbi.nlm.nih.gov/gene/91404 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003952 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA SFXN1 http://www.ncbi.nlm.nih.gov/gene/94081 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003953 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA SGK3 http://www.ncbi.nlm.nih.gov/gene/23678 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003954 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA SIAH1 http://www.ncbi.nlm.nih.gov/gene/6477 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003955 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA SIK1 http://www.ncbi.nlm.nih.gov/gene/150094 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003956 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA SLAMF1 http://www.ncbi.nlm.nih.gov/gene/6504 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003957 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA SLC7A5 http://www.ncbi.nlm.nih.gov/gene/8140 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003958 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA SNX11 http://www.ncbi.nlm.nih.gov/gene/29916 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003959 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA SORL1 http://www.ncbi.nlm.nih.gov/gene/6653 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003960 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA STARD13 http://www.ncbi.nlm.nih.gov/gene/90627 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003961 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA STK38L http://www.ncbi.nlm.nih.gov/gene/23012 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003962 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA SYNCRIP http://www.ncbi.nlm.nih.gov/gene/10492 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003963 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA TBL1XR1 http://www.ncbi.nlm.nih.gov/gene/79718 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003964 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA TCP11L1 http://www.ncbi.nlm.nih.gov/gene/55346 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003965 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA TGFBRAP1 http://www.ncbi.nlm.nih.gov/gene/9392 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003966 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA TMEM170A http://www.ncbi.nlm.nih.gov/gene/124491 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003967 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA TMEM214 http://www.ncbi.nlm.nih.gov/gene/54867 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003968 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA TNKS2 http://www.ncbi.nlm.nih.gov/gene/80351 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003969 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA TNRC6A http://www.ncbi.nlm.nih.gov/gene/27327 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003970 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA TRIM21 http://www.ncbi.nlm.nih.gov/gene/6737 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003971 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA TSC22D3 http://www.ncbi.nlm.nih.gov/gene/23151 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003972 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA TTLL11 http://www.ncbi.nlm.nih.gov/gene/158135 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00003973 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA UBE2D3 http://www.ncbi.nlm.nih.gov/gene/100037280 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003974 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA ZBTB11 http://www.ncbi.nlm.nih.gov/gene/27107 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003975 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA ZBTB6 http://www.ncbi.nlm.nih.gov/gene/10773 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003976 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA ZFYVE26 http://www.ncbi.nlm.nih.gov/gene/23503 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003977 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(ebv-mir-bart15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 Lymphoblastoid cell lines - Host mRNA ZNF460 http://www.ncbi.nlm.nih.gov/gene/10794 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00003978 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(miR-BART15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 AGS gastric carcinoma cell - Host Protein BIRC6(BRUCE) http://www.ncbi.nlm.nih.gov/gene/57448 Downregulation Quantitative Reverse Transcription PCR (QRT-PCR),Northern Blot,AGO2 Co-Immunoprecipitation. 23979421 It was indicated in transient transfection assay that miR-BART15 could suppress cell growth and induced early apoptosis in AGS gastric carcinoma cell in part through targeting the BRUCE gene. VHID00003979 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15(miR-BART15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 PMA-treated Thp-1 cells - Host Protein NLRP3 http://www.ncbi.nlm.nih.gov/gene/114548 Downregulation Quantitative PCR,Western blot,Luciferase experiments,Cytokine measurement. 22984081 We formally tested the ability of the viral miRNA to decrease the expression of the?NLRP3?3'-UTR luciferase construct and observed that only EBV miR-BART15 targeted this construct.Transfection of EBV miR-BART15 into PMA-treated Thp-1 cells reduced endogenous NLRP3 protein levels. VHID00003980 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(BART-16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 - - Host Protein TOMM22 http://www.ncbi.nlm.nih.gov/gene/56993 - PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 For each of them, direct interactions between 3'UTR and EBV miRNAs were confirmed by luciferase assay but no functional assay has been performed so far (Table 2).Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation (PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP) or RNA immunoprecipitation and microarray (RIP-Chip) techniques. Validation of these targets was done using luciferase reporter assays. VHID00003981 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA ALG10B http://www.ncbi.nlm.nih.gov/gene/144245 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003982 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA ALS2CR8 http://www.ncbi.nlm.nih.gov/gene/79800 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003983 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA ANKRD17 http://www.ncbi.nlm.nih.gov/gene/26057 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003984 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA ANLN http://www.ncbi.nlm.nih.gov/gene/54443 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003985 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA ATE1 http://www.ncbi.nlm.nih.gov/gene/11101 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003986 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA ATP2B4 http://www.ncbi.nlm.nih.gov/gene/493 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003987 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA ATP2C1 http://www.ncbi.nlm.nih.gov/gene/27032 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003988 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA ATXN1L http://www.ncbi.nlm.nih.gov/gene/342371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003989 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA B4GALT3 http://www.ncbi.nlm.nih.gov/gene/8703 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003990 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA BAZ2A http://www.ncbi.nlm.nih.gov/gene/11176 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003991 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA BRMS1L http://www.ncbi.nlm.nih.gov/gene/84312 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003992 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA BXDC2 http://www.ncbi.nlm.nih.gov/gene/55299 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003993 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA C10orf140 http://www.ncbi.nlm.nih.gov/gene/387640 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003994 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA C12orf5 http://www.ncbi.nlm.nih.gov/gene/57103 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003995 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA C14orf1 http://www.ncbi.nlm.nih.gov/gene/11161 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003996 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA C20orf177 http://www.ncbi.nlm.nih.gov/gene/63939 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003997 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA C7orf60 http://www.ncbi.nlm.nih.gov/gene/154743 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003998 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA CC2D1B http://www.ncbi.nlm.nih.gov/gene/200014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00003999 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA CCND2 http://www.ncbi.nlm.nih.gov/gene/894 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004000 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA CDR2 http://www.ncbi.nlm.nih.gov/gene/1039 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004001 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA CEP55 http://www.ncbi.nlm.nih.gov/gene/55165 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004002 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA CHRM3 http://www.ncbi.nlm.nih.gov/gene/1131 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004003 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA COG5 http://www.ncbi.nlm.nih.gov/gene/10466 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004004 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA COMMD2 http://www.ncbi.nlm.nih.gov/gene/51122 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004005 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA CREBBP http://www.ncbi.nlm.nih.gov/gene/1387 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004006 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA CSNK2A1 http://www.ncbi.nlm.nih.gov/gene/283106 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004007 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA DNAJB11 http://www.ncbi.nlm.nih.gov/gene/51726 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004008 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA DSTYK http://www.ncbi.nlm.nih.gov/gene/25778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004009 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA EBPL http://www.ncbi.nlm.nih.gov/gene/84650 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004010 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA EIF2AK2 http://www.ncbi.nlm.nih.gov/gene/5610 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004011 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA ENOPH1 http://www.ncbi.nlm.nih.gov/gene/58478 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004012 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA F2R http://www.ncbi.nlm.nih.gov/gene/2149 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004013 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA FBXO22 http://www.ncbi.nlm.nih.gov/gene/26263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004014 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA FKBP14 http://www.ncbi.nlm.nih.gov/gene/55033 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004015 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA FLAD1 http://www.ncbi.nlm.nih.gov/gene/80308 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004016 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA FLVCR1 http://www.ncbi.nlm.nih.gov/gene/28982 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004017 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA FRMD4B http://www.ncbi.nlm.nih.gov/gene/23150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004018 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA G3BP2 http://www.ncbi.nlm.nih.gov/gene/9908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004019 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA GCET2 http://www.ncbi.nlm.nih.gov/gene/257144 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004020 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA GLCCI1 http://www.ncbi.nlm.nih.gov/gene/113263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004021 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA HMGCS1 http://www.ncbi.nlm.nih.gov/gene/3157 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004022 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA HP1BP3 http://www.ncbi.nlm.nih.gov/gene/50809 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004023 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA INPP4A http://www.ncbi.nlm.nih.gov/gene/3631 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004024 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA KBTBD2 http://www.ncbi.nlm.nih.gov/gene/25948 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004025 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA KIAA0090 http://www.ncbi.nlm.nih.gov/gene/23065 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004026 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA KIAA1432 http://www.ncbi.nlm.nih.gov/gene/57589 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004027 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA KIAA1826 http://www.ncbi.nlm.nih.gov/gene/84437 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004028 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA KIF21A http://www.ncbi.nlm.nih.gov/gene/55605 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004029 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA KLF12 http://www.ncbi.nlm.nih.gov/gene/11278 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004030 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA KLF3 http://www.ncbi.nlm.nih.gov/gene/51274 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004031 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA KLHL8 http://www.ncbi.nlm.nih.gov/gene/57563 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004032 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA LACTB2 http://www.ncbi.nlm.nih.gov/gene/51110 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004033 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA LANCL1 http://www.ncbi.nlm.nih.gov/gene/10314 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004034 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA LIN54 http://www.ncbi.nlm.nih.gov/gene/132660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004035 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA MFSD9 http://www.ncbi.nlm.nih.gov/gene/84804 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004036 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA MKRN2 http://www.ncbi.nlm.nih.gov/gene/23609 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004037 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA MOBKL1B http://www.ncbi.nlm.nih.gov/gene/55233 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004038 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA MRP63 http://www.ncbi.nlm.nih.gov/gene/78988 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004039 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA MYPOP http://www.ncbi.nlm.nih.gov/gene/339344 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004040 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA NAPG http://www.ncbi.nlm.nih.gov/gene/8774 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004041 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA NCOA2 http://www.ncbi.nlm.nih.gov/gene/10499 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004042 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA NCOR1 http://www.ncbi.nlm.nih.gov/gene/9611 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004043 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA NHLRC2 http://www.ncbi.nlm.nih.gov/gene/374354 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004044 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA NME6 http://www.ncbi.nlm.nih.gov/gene/10201 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004045 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA NR2C1 http://www.ncbi.nlm.nih.gov/gene/7181 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004046 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA NRAS http://www.ncbi.nlm.nih.gov/gene/4893 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004047 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA NUDT15 http://www.ncbi.nlm.nih.gov/gene/55270 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004048 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA OXCT1 http://www.ncbi.nlm.nih.gov/gene/5019 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004049 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA PANK3 http://www.ncbi.nlm.nih.gov/gene/79646 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004050 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA PAPOLA http://www.ncbi.nlm.nih.gov/gene/10914 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004051 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA PCDH10 http://www.ncbi.nlm.nih.gov/gene/57575 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004052 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA PDCD4 http://www.ncbi.nlm.nih.gov/gene/27250 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004053 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA PHLPP2 http://www.ncbi.nlm.nih.gov/gene/23035 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004054 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA PJA2 http://www.ncbi.nlm.nih.gov/gene/9867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004055 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA PLDN http://www.ncbi.nlm.nih.gov/gene/26258 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004056 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA PMS1 http://www.ncbi.nlm.nih.gov/gene/5378 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004057 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA POGZ http://www.ncbi.nlm.nih.gov/gene/23126 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004058 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA PPP3CA http://www.ncbi.nlm.nih.gov/gene/5530 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004059 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA PRDM4 http://www.ncbi.nlm.nih.gov/gene/11108 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004060 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA PREPL http://www.ncbi.nlm.nih.gov/gene/9581 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004061 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA PRKAR1A http://www.ncbi.nlm.nih.gov/gene/5573 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004062 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA PTP4A2 http://www.ncbi.nlm.nih.gov/gene/8073 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004063 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA PUS7L http://www.ncbi.nlm.nih.gov/gene/83448 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004064 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA RAB11FIP1 http://www.ncbi.nlm.nih.gov/gene/80223 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004065 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA RASSF8 http://www.ncbi.nlm.nih.gov/gene/11228 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004066 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA RBPSUH http://www.ncbi.nlm.nih.gov/gene/3516 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004067 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA REEP3 http://www.ncbi.nlm.nih.gov/gene/221035 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004068 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA RFWD2 http://www.ncbi.nlm.nih.gov/gene/64326 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004069 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA RHPN2 http://www.ncbi.nlm.nih.gov/gene/85415 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004070 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA RIMBP2 http://www.ncbi.nlm.nih.gov/gene/23504 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004071 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA RIT1 http://www.ncbi.nlm.nih.gov/gene/6016 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004072 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA RSBN1 http://www.ncbi.nlm.nih.gov/gene/54665 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004073 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA RTN4 http://www.ncbi.nlm.nih.gov/gene/57142 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004074 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA RUNX2 http://www.ncbi.nlm.nih.gov/gene/860 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004075 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA SCARB2 http://www.ncbi.nlm.nih.gov/gene/950 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004076 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA SEC62 http://www.ncbi.nlm.nih.gov/gene/7095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004077 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA SETD5 http://www.ncbi.nlm.nih.gov/gene/55209 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004078 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA SFRS18 http://www.ncbi.nlm.nih.gov/gene/25957 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004079 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA SLC25A36 http://www.ncbi.nlm.nih.gov/gene/55186 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004080 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA SMG7 http://www.ncbi.nlm.nih.gov/gene/9887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004081 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA SNX16 http://www.ncbi.nlm.nih.gov/gene/64089 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004082 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA SUB1 http://www.ncbi.nlm.nih.gov/gene/10923 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004083 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA TBC1D20 http://www.ncbi.nlm.nih.gov/gene/128637 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004084 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA TMEM168 http://www.ncbi.nlm.nih.gov/gene/64418 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004085 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA TOMM22 http://www.ncbi.nlm.nih.gov/gene/56993 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004086 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA TP53BP2 http://www.ncbi.nlm.nih.gov/gene/7159 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004087 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA TP53INP1 http://www.ncbi.nlm.nih.gov/gene/94241 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004088 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA TWSG1 http://www.ncbi.nlm.nih.gov/gene/57045 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004089 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA UHMK1 http://www.ncbi.nlm.nih.gov/gene/127933 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004090 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA USP14 http://www.ncbi.nlm.nih.gov/gene/9097 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004091 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA UTP23 http://www.ncbi.nlm.nih.gov/gene/84294 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004092 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA WASL http://www.ncbi.nlm.nih.gov/gene/8976 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004093 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA WDR26 http://www.ncbi.nlm.nih.gov/gene/80232 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004094 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA WWTR1 http://www.ncbi.nlm.nih.gov/gene/25937 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004095 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA XPO4 http://www.ncbi.nlm.nih.gov/gene/64328 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004096 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA ZBTB39 http://www.ncbi.nlm.nih.gov/gene/9880 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004097 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA ZBTB4 http://www.ncbi.nlm.nih.gov/gene/57659 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004098 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA ZFAND1 http://www.ncbi.nlm.nih.gov/gene/79752 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004099 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA ZMAT3 http://www.ncbi.nlm.nih.gov/gene/64393 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004100 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA ZNF146 http://www.ncbi.nlm.nih.gov/gene/7705 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004101 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA ZNF451 http://www.ncbi.nlm.nih.gov/gene/26036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004102 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA ZNF512B http://www.ncbi.nlm.nih.gov/gene/57473 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004103 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA ZNF618 http://www.ncbi.nlm.nih.gov/gene/114991 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004104 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA ZNF626 http://www.ncbi.nlm.nih.gov/gene/199777 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004105 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(ebv-mir-bart16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 BC-1 - Host mRNA ZNF776 http://www.ncbi.nlm.nih.gov/gene/284309 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004106 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(miR-BART16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 - - Host Protein TOMM22 http://www.ncbi.nlm.nih.gov/gene/56993 - Report arrays. 22100165 We detected the reported cluster, containing a seed match to miRBART16. We also detected an additional cluster with a seed match to miR-BART6-3p. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00004107 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(miR-BART16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 293T cells - Host Protein NFKB1 http://www.ncbi.nlm.nih.gov/gene/4790 Downregulation luciferase reporter assays, photoactivatable cross-linking and immunoprecipitation(PAR-CLIP), and deep sequencing and qRT-PCR. 24257599 These data demonstrate that miR-rL1-8 can functionally substitute for miRBART5 and that miR-BART5 and miR-BART16 negatively regulate NFKB signaling by directly targeting the LMP1 3'UTR. VHID00004108 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART2(BART2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001068 - - Host Protein OTUD1 http://www.ncbi.nlm.nih.gov/gene/220213 - PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 For each of them, direct interactions between 3'UTR and EBV miRNAs were confirmed by luciferase assay but no functional assay has been performed so far (Table 2).Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation (PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP) or RNA immunoprecipitation and microarray (RIP-Chip) techniques. Validation of these targets was done using luciferase reporter assays. VHID00004109 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART2(BART2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001068 - - Host Protein PELI1 http://www.ncbi.nlm.nih.gov/gene/57162 - PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 For each of them, direct interactions between 3'UTR and EBV miRNAs were confirmed by luciferase assay but no functional assay has been performed so far (Table 2).Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation (PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP) or RNA immunoprecipitation and microarray (RIP-Chip) techniques. Validation of these targets was done using luciferase reporter assays. VHID00004110 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART2-5p(miR-BART2-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001000 - - Host mRNA MICB http://www.ncbi.nlm.nih.gov/gene/4277 Downregulation Quantitative Real-Time PCR, Luciferase Assay, Western Blot. 19380116 Thus, we identified the specific binding sites of miR-K12-7 and of miR-BART2-5p in the 3'UTR of MICB and can now consider the strategy of MICB miRNA targeting as a common trait of human herpesviruses. VHID00004111 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ABHD10 http://www.ncbi.nlm.nih.gov/gene/55347 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004112 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ACOX1 http://www.ncbi.nlm.nih.gov/gene/51 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004113 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ACSL3 http://www.ncbi.nlm.nih.gov/gene/2181 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004114 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ACSL4 http://www.ncbi.nlm.nih.gov/gene/2182 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004115 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA AKAP13 http://www.ncbi.nlm.nih.gov/gene/11214 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004116 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA AKIRIN1 http://www.ncbi.nlm.nih.gov/gene/79647 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004117 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA AMBRA1 http://www.ncbi.nlm.nih.gov/gene/55626 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004118 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA AMFR http://www.ncbi.nlm.nih.gov/gene/267 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004119 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ANGEL2 http://www.ncbi.nlm.nih.gov/gene/90806 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004120 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ANKRD13C http://www.ncbi.nlm.nih.gov/gene/81573 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004121 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ANKRD40 http://www.ncbi.nlm.nih.gov/gene/91369 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004122 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA AP1S3 http://www.ncbi.nlm.nih.gov/gene/130340 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004123 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA API5L1 http://www.ncbi.nlm.nih.gov/gene/8539 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004124 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA APLP2 http://www.ncbi.nlm.nih.gov/gene/334 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004125 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA APPL2 http://www.ncbi.nlm.nih.gov/gene/55198 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004126 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ARHGAP11A http://www.ncbi.nlm.nih.gov/gene/89839 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004127 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ARHGAP12 http://www.ncbi.nlm.nih.gov/gene/94134 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004128 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ARID4B http://www.ncbi.nlm.nih.gov/gene/51742 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004129 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ARL5A http://www.ncbi.nlm.nih.gov/gene/26225 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004130 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ATG2B http://www.ncbi.nlm.nih.gov/gene/55102 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004131 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ATIC http://www.ncbi.nlm.nih.gov/gene/471 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004132 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ATL2 http://www.ncbi.nlm.nih.gov/gene/64225 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004133 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ATP11A http://www.ncbi.nlm.nih.gov/gene/23250 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004134 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ATP11C http://www.ncbi.nlm.nih.gov/gene/286410 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004135 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA B3GNT1 http://www.ncbi.nlm.nih.gov/gene/10678 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004136 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA B4GALT1 http://www.ncbi.nlm.nih.gov/gene/2683 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004137 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA BAX http://www.ncbi.nlm.nih.gov/gene/581 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004138 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA BBS10 http://www.ncbi.nlm.nih.gov/gene/79738 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004139 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA BCL2L11 http://www.ncbi.nlm.nih.gov/gene/10018 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004140 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA BCL3 http://www.ncbi.nlm.nih.gov/gene/602 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004141 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA BHLHB9 http://www.ncbi.nlm.nih.gov/gene/80823 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004142 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA BNC2 http://www.ncbi.nlm.nih.gov/gene/54796 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004143 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA BRWD1 http://www.ncbi.nlm.nih.gov/gene/54014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004144 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA BSDC1 http://www.ncbi.nlm.nih.gov/gene/55108 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004145 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA BTBD7 http://www.ncbi.nlm.nih.gov/gene/55727 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004146 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA C10orf18 http://www.ncbi.nlm.nih.gov/gene/54906 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004147 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA C11orf10 http://www.ncbi.nlm.nih.gov/gene/746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004148 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA C11orf79 http://www.ncbi.nlm.nih.gov/gene/54949 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004149 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA C12orf28 http://www.ncbi.nlm.nih.gov/gene/196446 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004150 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA C14orf135 http://www.ncbi.nlm.nih.gov/gene/64430 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004151 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA C14orf147 http://www.ncbi.nlm.nih.gov/gene/171546 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004152 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA C1orf52 http://www.ncbi.nlm.nih.gov/gene/148423 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004153 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA C1orf55 http://www.ncbi.nlm.nih.gov/gene/163859 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004154 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA C1orf9 http://www.ncbi.nlm.nih.gov/gene/51430 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004155 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA C20orf112 http://www.ncbi.nlm.nih.gov/gene/140688 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004156 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA C22orf40 http://www.ncbi.nlm.nih.gov/gene/150383 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004157 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA C4orf29 http://www.ncbi.nlm.nih.gov/gene/80167 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004158 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA C4orf30 http://www.ncbi.nlm.nih.gov/gene/54876 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004159 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA C5orf37 http://www.ncbi.nlm.nih.gov/gene/134359 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004160 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA C5orf41 http://www.ncbi.nlm.nih.gov/gene/153222 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004161 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CAB39 http://www.ncbi.nlm.nih.gov/gene/51719 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004162 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CACYBP http://www.ncbi.nlm.nih.gov/gene/644877 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004163 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CAMSAP1L1 http://www.ncbi.nlm.nih.gov/gene/23271 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004164 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CANT1 http://www.ncbi.nlm.nih.gov/gene/124583 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004165 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CANX http://www.ncbi.nlm.nih.gov/gene/821 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004166 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CAPRIN1 http://www.ncbi.nlm.nih.gov/gene/4076 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004167 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CAPZA1 http://www.ncbi.nlm.nih.gov/gene/829 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004168 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CASC5 http://www.ncbi.nlm.nih.gov/gene/57082 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004169 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CASD1 http://www.ncbi.nlm.nih.gov/gene/64921 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004170 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CASP3 http://www.ncbi.nlm.nih.gov/gene/836 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004171 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CASP7 http://www.ncbi.nlm.nih.gov/gene/840 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004172 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CBX5 http://www.ncbi.nlm.nih.gov/gene/23468 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004173 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CCDC14 http://www.ncbi.nlm.nih.gov/gene/64770 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004174 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CCNG1 http://www.ncbi.nlm.nih.gov/gene/900 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004175 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CCNI http://www.ncbi.nlm.nih.gov/gene/10983 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004176 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004177 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CD164 http://www.ncbi.nlm.nih.gov/gene/8763 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004178 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CD86 http://www.ncbi.nlm.nih.gov/gene/942 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004179 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CD97 http://www.ncbi.nlm.nih.gov/gene/976 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004180 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CDC25C http://www.ncbi.nlm.nih.gov/gene/995 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004181 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CDC37L1 http://www.ncbi.nlm.nih.gov/gene/55664 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004182 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CDC42 http://www.ncbi.nlm.nih.gov/gene/998 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004183 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CDK6 http://www.ncbi.nlm.nih.gov/gene/1021 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004184 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CDV3 http://www.ncbi.nlm.nih.gov/gene/55573 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004185 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CEP120 http://www.ncbi.nlm.nih.gov/gene/153241 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004186 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CEP350 http://www.ncbi.nlm.nih.gov/gene/9857 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004187 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CFL2 http://www.ncbi.nlm.nih.gov/gene/1073 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004188 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CHD5 http://www.ncbi.nlm.nih.gov/gene/26038 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004189 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CHD7 http://www.ncbi.nlm.nih.gov/gene/55636 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004190 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CLDN12 http://www.ncbi.nlm.nih.gov/gene/9069 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004191 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA COL4A3BP http://www.ncbi.nlm.nih.gov/gene/10087 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004192 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA COMMD2 http://www.ncbi.nlm.nih.gov/gene/51122 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004193 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA COPS8 http://www.ncbi.nlm.nih.gov/gene/10920 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004194 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CPEB2 http://www.ncbi.nlm.nih.gov/gene/132864 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004195 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CPEB3 http://www.ncbi.nlm.nih.gov/gene/22849 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004196 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CPEB4 http://www.ncbi.nlm.nih.gov/gene/80315 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004197 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CPNE3 http://www.ncbi.nlm.nih.gov/gene/8895 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004198 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CREB1 http://www.ncbi.nlm.nih.gov/gene/1385 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004199 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CRK http://www.ncbi.nlm.nih.gov/gene/1398 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004200 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CSDE1 http://www.ncbi.nlm.nih.gov/gene/7812 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004201 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA CUGBP1 http://www.ncbi.nlm.nih.gov/gene/10658 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004202 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA DCAF5 http://www.ncbi.nlm.nih.gov/gene/8816 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004203 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA DCAF7 http://www.ncbi.nlm.nih.gov/gene/10238 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004204 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA DCTN6 http://www.ncbi.nlm.nih.gov/gene/10671 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004205 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA DDHD1 http://www.ncbi.nlm.nih.gov/gene/80821 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004206 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA DDHD2 http://www.ncbi.nlm.nih.gov/gene/23259 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004207 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA DDI2 http://www.ncbi.nlm.nih.gov/gene/84301 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004208 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA DDX19A http://www.ncbi.nlm.nih.gov/gene/55308 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004209 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA DDX3Y http://www.ncbi.nlm.nih.gov/gene/8653 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004210 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA DHX40 http://www.ncbi.nlm.nih.gov/gene/100134387 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004211 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA DIP2C http://www.ncbi.nlm.nih.gov/gene/22982 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004212 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA DLG5 http://www.ncbi.nlm.nih.gov/gene/9231 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004213 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA DNAJB9 http://www.ncbi.nlm.nih.gov/gene/4189 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004214 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA DNM1L http://www.ncbi.nlm.nih.gov/gene/10059 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004215 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA DRAM1 http://www.ncbi.nlm.nih.gov/gene/55332 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004216 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA E2F3 http://www.ncbi.nlm.nih.gov/gene/1871 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004217 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA E2F7 http://www.ncbi.nlm.nih.gov/gene/144455 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004218 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA EGR1 http://www.ncbi.nlm.nih.gov/gene/1958 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004219 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ELK4 http://www.ncbi.nlm.nih.gov/gene/2005 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004220 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ERLIN2 http://www.ncbi.nlm.nih.gov/gene/11160 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004221 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA EXOC8 http://www.ncbi.nlm.nih.gov/gene/149371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004222 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA FAM126A http://www.ncbi.nlm.nih.gov/gene/84668 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004223 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA FAM160B1 http://www.ncbi.nlm.nih.gov/gene/57700 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004224 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA FAM169A http://www.ncbi.nlm.nih.gov/gene/26049 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004225 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA FAM49B http://www.ncbi.nlm.nih.gov/gene/51571 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004226 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA FAU http://www.ncbi.nlm.nih.gov/gene/2197 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004227 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA FBN1 http://www.ncbi.nlm.nih.gov/gene/2200 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004228 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA FBXO30 http://www.ncbi.nlm.nih.gov/gene/84085 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004229 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA FBXO45 http://www.ncbi.nlm.nih.gov/gene/200933 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004230 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA FNDC3A http://www.ncbi.nlm.nih.gov/gene/22862 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004231 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA FNDC3B http://www.ncbi.nlm.nih.gov/gene/64778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004232 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA FZD6 http://www.ncbi.nlm.nih.gov/gene/8323 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004233 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA G3BP1 http://www.ncbi.nlm.nih.gov/gene/10146 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004234 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA G3BP2 http://www.ncbi.nlm.nih.gov/gene/9908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004235 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA GABPB1 http://www.ncbi.nlm.nih.gov/gene/2553 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004236 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA GADD45A http://www.ncbi.nlm.nih.gov/gene/1647 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004237 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA GALNT7 http://www.ncbi.nlm.nih.gov/gene/51809 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004238 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA GAN http://www.ncbi.nlm.nih.gov/gene/8139 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004239 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA GEMIN5 http://www.ncbi.nlm.nih.gov/gene/25929 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004240 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA GLT8D3 http://www.ncbi.nlm.nih.gov/gene/283464 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004241 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA GMPS http://www.ncbi.nlm.nih.gov/gene/8833 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004242 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA GRPEL2 http://www.ncbi.nlm.nih.gov/gene/134266 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004243 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA H2AFV http://www.ncbi.nlm.nih.gov/gene/94239 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004244 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA H2AFZ http://www.ncbi.nlm.nih.gov/gene/3015 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004245 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA HADHB http://www.ncbi.nlm.nih.gov/gene/3032 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004246 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA HCFC2 http://www.ncbi.nlm.nih.gov/gene/29915 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004247 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA HDGF http://www.ncbi.nlm.nih.gov/gene/3068 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004248 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA HIP1 http://www.ncbi.nlm.nih.gov/gene/3092 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004249 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA HIPK1 http://www.ncbi.nlm.nih.gov/gene/204851 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004250 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA HMGB2 http://www.ncbi.nlm.nih.gov/gene/3148 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004251 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA HMGN3 http://www.ncbi.nlm.nih.gov/gene/9324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004252 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA HNRNPU http://www.ncbi.nlm.nih.gov/gene/3192 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004253 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA HSD17B10 http://www.ncbi.nlm.nih.gov/gene/3028 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004254 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA HSPA1B http://www.ncbi.nlm.nih.gov/gene/3303 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004255 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ICK http://www.ncbi.nlm.nih.gov/gene/22858 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004256 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA IGF1R http://www.ncbi.nlm.nih.gov/gene/3480 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004257 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA INO80D http://www.ncbi.nlm.nih.gov/gene/54891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004258 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA INTS2 http://www.ncbi.nlm.nih.gov/gene/57508 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004259 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA IQGAP2 http://www.ncbi.nlm.nih.gov/gene/10788 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004260 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA IREB2 http://www.ncbi.nlm.nih.gov/gene/3658 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004261 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA IRF4 http://www.ncbi.nlm.nih.gov/gene/3662 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004262 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA JMJD1C http://www.ncbi.nlm.nih.gov/gene/221037 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004263 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA JUND http://www.ncbi.nlm.nih.gov/gene/3727 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004264 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA KCTD20 http://www.ncbi.nlm.nih.gov/gene/222658 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004265 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA KIAA0776 http://www.ncbi.nlm.nih.gov/gene/23376 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004266 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA KIAA0892 http://www.ncbi.nlm.nih.gov/gene/23383 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004267 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA KIAA0895 http://www.ncbi.nlm.nih.gov/gene/23366 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004268 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA KIF5B http://www.ncbi.nlm.nih.gov/gene/3799 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004269 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA KLF13 http://www.ncbi.nlm.nih.gov/gene/51621 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004270 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA KLF9 http://www.ncbi.nlm.nih.gov/gene/687 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004271 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA KLHDC5 http://www.ncbi.nlm.nih.gov/gene/57542 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004272 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA KPNA1 http://www.ncbi.nlm.nih.gov/gene/3836 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004273 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA KPNA5 http://www.ncbi.nlm.nih.gov/gene/3841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004274 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA LAMC1 http://www.ncbi.nlm.nih.gov/gene/3915 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004275 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA LARP4 http://www.ncbi.nlm.nih.gov/gene/113251 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004276 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA LCOR http://www.ncbi.nlm.nih.gov/gene/84458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004277 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA LETM1 http://www.ncbi.nlm.nih.gov/gene/3954 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004278 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA LIMA1 http://www.ncbi.nlm.nih.gov/gene/51474 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004279 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA LMAN1 http://www.ncbi.nlm.nih.gov/gene/3998 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004280 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA LRRC58 http://www.ncbi.nlm.nih.gov/gene/116064 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004281 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA LRRC8D http://www.ncbi.nlm.nih.gov/gene/55144 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004282 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MAGEF1 http://www.ncbi.nlm.nih.gov/gene/64110 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004283 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MAP3K13 http://www.ncbi.nlm.nih.gov/gene/9175 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004284 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MAP3K2 http://www.ncbi.nlm.nih.gov/gene/10746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004285 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MAP3K5 http://www.ncbi.nlm.nih.gov/gene/4217 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004286 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MAP3K7IP2 http://www.ncbi.nlm.nih.gov/gene/23118 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004287 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MAP4K3 http://www.ncbi.nlm.nih.gov/gene/8491 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004288 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MAPK1 http://www.ncbi.nlm.nih.gov/gene/5594 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004289 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MAPK1IP1L http://www.ncbi.nlm.nih.gov/gene/93487 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004290 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MAPK6 http://www.ncbi.nlm.nih.gov/gene/5597 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004291 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MATR3 http://www.ncbi.nlm.nih.gov/gene/9782 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004292 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MBIP http://www.ncbi.nlm.nih.gov/gene/51562 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004293 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MBNL1 http://www.ncbi.nlm.nih.gov/gene/4154 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004294 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MCL1 http://www.ncbi.nlm.nih.gov/gene/4170 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004295 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MDM2 http://www.ncbi.nlm.nih.gov/gene/4193 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004296 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MGEA5 http://www.ncbi.nlm.nih.gov/gene/10724 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004297 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MITF http://www.ncbi.nlm.nih.gov/gene/4286 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004298 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MKL2 http://www.ncbi.nlm.nih.gov/gene/57496 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004299 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MLL2 http://www.ncbi.nlm.nih.gov/gene/8085 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004300 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MLL3 http://www.ncbi.nlm.nih.gov/gene/58508 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004301 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MOSPD2 http://www.ncbi.nlm.nih.gov/gene/158747 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004302 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MPZL3 http://www.ncbi.nlm.nih.gov/gene/196264 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004303 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MRPL51 http://www.ncbi.nlm.nih.gov/gene/51258 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004304 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MRPS21 http://www.ncbi.nlm.nih.gov/gene/54460 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004305 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MRPS30 http://www.ncbi.nlm.nih.gov/gene/10884 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004306 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MSH3 http://www.ncbi.nlm.nih.gov/gene/4437 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004307 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MTDH http://www.ncbi.nlm.nih.gov/gene/92140 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004308 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MTM1 http://www.ncbi.nlm.nih.gov/gene/4534 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004309 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MTPN http://www.ncbi.nlm.nih.gov/gene/767558 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004310 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MTUS1 http://www.ncbi.nlm.nih.gov/gene/57509 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004311 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MTX3 http://www.ncbi.nlm.nih.gov/gene/345778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004312 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MXD1 http://www.ncbi.nlm.nih.gov/gene/4084 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004313 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA MYST3 http://www.ncbi.nlm.nih.gov/gene/7994 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004314 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA N4BP1 http://www.ncbi.nlm.nih.gov/gene/9683 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004315 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA NCK1 http://www.ncbi.nlm.nih.gov/gene/4690 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004316 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA NDRG1 http://www.ncbi.nlm.nih.gov/gene/10397 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004317 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA NEK4 http://www.ncbi.nlm.nih.gov/gene/6787 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004318 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004319 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA NHLRC3 http://www.ncbi.nlm.nih.gov/gene/387921 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004320 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA NPM1 http://www.ncbi.nlm.nih.gov/gene/100129237 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004321 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA NR3C1 http://www.ncbi.nlm.nih.gov/gene/2908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004322 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA NSD1 http://www.ncbi.nlm.nih.gov/gene/64324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004323 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA NUCKS1 http://www.ncbi.nlm.nih.gov/gene/64710 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004324 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA NUDT4P1 http://www.ncbi.nlm.nih.gov/gene/440672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004325 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA NUDT5 http://www.ncbi.nlm.nih.gov/gene/11164 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004326 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA NUP160 http://www.ncbi.nlm.nih.gov/gene/23279 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004327 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA NUPL1 http://www.ncbi.nlm.nih.gov/gene/9818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004328 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA OAT http://www.ncbi.nlm.nih.gov/gene/4942 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004329 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ODF2L http://www.ncbi.nlm.nih.gov/gene/57489 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004330 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ORMDL3 http://www.ncbi.nlm.nih.gov/gene/94103 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004331 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA OSBPL8 http://www.ncbi.nlm.nih.gov/gene/114882 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004332 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PACRGL http://www.ncbi.nlm.nih.gov/gene/133015 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004333 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PAK2 http://www.ncbi.nlm.nih.gov/gene/5062 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004334 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PCDHB2 http://www.ncbi.nlm.nih.gov/gene/56133 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004335 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PCGF3 http://www.ncbi.nlm.nih.gov/gene/10336 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004336 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PCMTD2 http://www.ncbi.nlm.nih.gov/gene/55251 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004337 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PDCD10 http://www.ncbi.nlm.nih.gov/gene/11235 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004338 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PDCL http://www.ncbi.nlm.nih.gov/gene/5082 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004339 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PIGN http://www.ncbi.nlm.nih.gov/gene/23556 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004340 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PIKFYVE http://www.ncbi.nlm.nih.gov/gene/200576 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004341 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PIP4K2C http://www.ncbi.nlm.nih.gov/gene/79837 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004342 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PITPNB http://www.ncbi.nlm.nih.gov/gene/23760 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004343 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PMS1 http://www.ncbi.nlm.nih.gov/gene/5378 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004344 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PNRC1 http://www.ncbi.nlm.nih.gov/gene/10957 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004345 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA POLR1D http://www.ncbi.nlm.nih.gov/gene/51082 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004346 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA POMP http://www.ncbi.nlm.nih.gov/gene/51371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004347 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA POU6F1 http://www.ncbi.nlm.nih.gov/gene/5463 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004348 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PPIB http://www.ncbi.nlm.nih.gov/gene/5479 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004349 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PPP1R12A http://www.ncbi.nlm.nih.gov/gene/4659 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004350 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PPP2CA http://www.ncbi.nlm.nih.gov/gene/5515 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004351 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PPP3CA http://www.ncbi.nlm.nih.gov/gene/5530 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004352 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PPP3R1 http://www.ncbi.nlm.nih.gov/gene/5534 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004353 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PPP4R2 http://www.ncbi.nlm.nih.gov/gene/151987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004354 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PPTC7 http://www.ncbi.nlm.nih.gov/gene/160760 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004355 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PRICKLE2 http://www.ncbi.nlm.nih.gov/gene/166336 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004356 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PRNP http://www.ncbi.nlm.nih.gov/gene/5621 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004357 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PROK2 http://www.ncbi.nlm.nih.gov/gene/60675 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004358 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PRR13 http://www.ncbi.nlm.nih.gov/gene/54458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004359 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PSAT1 http://www.ncbi.nlm.nih.gov/gene/137133 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004360 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PSMB4 http://www.ncbi.nlm.nih.gov/gene/5692 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004361 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PSMB9 http://www.ncbi.nlm.nih.gov/gene/5698 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004362 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PTPRC http://www.ncbi.nlm.nih.gov/gene/5788 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004363 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PUM2 http://www.ncbi.nlm.nih.gov/gene/23369 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004364 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA PUS7 http://www.ncbi.nlm.nih.gov/gene/54517 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004365 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA RAB11A http://www.ncbi.nlm.nih.gov/gene/8766 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004366 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA RAB11B http://www.ncbi.nlm.nih.gov/gene/9230 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004367 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA RAB11FIP2 http://www.ncbi.nlm.nih.gov/gene/22841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004368 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA RAB12 http://www.ncbi.nlm.nih.gov/gene/201475 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004369 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA RAB14 http://www.ncbi.nlm.nih.gov/gene/51552 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004370 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA RALGPS2 http://www.ncbi.nlm.nih.gov/gene/55103 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004371 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA RANBP9 http://www.ncbi.nlm.nih.gov/gene/10048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004372 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA RAP2C http://www.ncbi.nlm.nih.gov/gene/57826 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004373 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA RBM12 http://www.ncbi.nlm.nih.gov/gene/10137 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004374 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA REST http://www.ncbi.nlm.nih.gov/gene/5978 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004375 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA RGS1 http://www.ncbi.nlm.nih.gov/gene/5996 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004376 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA RHBDF2 http://www.ncbi.nlm.nih.gov/gene/79651 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004377 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA RNF125 http://www.ncbi.nlm.nih.gov/gene/54941 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004378 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA RNF169 http://www.ncbi.nlm.nih.gov/gene/254225 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004379 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA RORA http://www.ncbi.nlm.nih.gov/gene/6095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004380 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA RPAP2 http://www.ncbi.nlm.nih.gov/gene/79871 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004381 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA RPL13A http://www.ncbi.nlm.nih.gov/gene/284821 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004382 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA RPRD1A http://www.ncbi.nlm.nih.gov/gene/55197 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004383 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA RRM2B http://www.ncbi.nlm.nih.gov/gene/50484 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004384 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA RTF1 http://www.ncbi.nlm.nih.gov/gene/23168 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004385 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA RUFY2 http://www.ncbi.nlm.nih.gov/gene/55680 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004386 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SERINC1 http://www.ncbi.nlm.nih.gov/gene/57515 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004387 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SETD1B http://www.ncbi.nlm.nih.gov/gene/23067 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004388 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SETD5 http://www.ncbi.nlm.nih.gov/gene/55209 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004389 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SETD7 http://www.ncbi.nlm.nih.gov/gene/80854 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004390 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SF3B2 http://www.ncbi.nlm.nih.gov/gene/10992 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004391 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SFPQ http://www.ncbi.nlm.nih.gov/gene/6421 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004392 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SFRS8 http://www.ncbi.nlm.nih.gov/gene/6433 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004393 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SIRT1 http://www.ncbi.nlm.nih.gov/gene/23411 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004394 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SLC16A14 http://www.ncbi.nlm.nih.gov/gene/151473 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004395 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SLC30A6 http://www.ncbi.nlm.nih.gov/gene/55676 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004396 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SMAD2 http://www.ncbi.nlm.nih.gov/gene/4087 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004397 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SMAD3 http://www.ncbi.nlm.nih.gov/gene/4088 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004398 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SMAD5 http://www.ncbi.nlm.nih.gov/gene/4090 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004399 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SMG1 http://www.ncbi.nlm.nih.gov/gene/23049 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004400 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SMG7 http://www.ncbi.nlm.nih.gov/gene/9887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004401 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SMNDC1 http://www.ncbi.nlm.nih.gov/gene/10285 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004402 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SMYD5 http://www.ncbi.nlm.nih.gov/gene/10322 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004403 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SNIP1 http://www.ncbi.nlm.nih.gov/gene/79753 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004404 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SOCS5 http://www.ncbi.nlm.nih.gov/gene/9655 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004405 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SOCS6 http://www.ncbi.nlm.nih.gov/gene/9306 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004406 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SOS1 http://www.ncbi.nlm.nih.gov/gene/6654 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004407 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SPCS3 http://www.ncbi.nlm.nih.gov/gene/60559 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004408 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SPRED1 http://www.ncbi.nlm.nih.gov/gene/161742 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004409 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SQSTM1 http://www.ncbi.nlm.nih.gov/gene/8878 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004410 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SSB http://www.ncbi.nlm.nih.gov/gene/6741 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004411 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA STARD3NL http://www.ncbi.nlm.nih.gov/gene/83930 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004412 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA STARD4 http://www.ncbi.nlm.nih.gov/gene/134429 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004413 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA STAT3 http://www.ncbi.nlm.nih.gov/gene/6774 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004414 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA STK35 http://www.ncbi.nlm.nih.gov/gene/140901 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004415 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA STXBP3 http://www.ncbi.nlm.nih.gov/gene/6814 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004416 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SYNCRIP http://www.ncbi.nlm.nih.gov/gene/10492 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004417 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA SYT4 http://www.ncbi.nlm.nih.gov/gene/6860 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004418 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TANK http://www.ncbi.nlm.nih.gov/gene/10010 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004419 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TAOK1 http://www.ncbi.nlm.nih.gov/gene/57551 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004420 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TBCC http://www.ncbi.nlm.nih.gov/gene/6903 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004421 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TBL1XR1 http://www.ncbi.nlm.nih.gov/gene/79718 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004422 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TET2 http://www.ncbi.nlm.nih.gov/gene/54790 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004423 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TET3 http://www.ncbi.nlm.nih.gov/gene/200424 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004424 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TFRC http://www.ncbi.nlm.nih.gov/gene/7037 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004425 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA THAP5 http://www.ncbi.nlm.nih.gov/gene/168451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004426 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA THRAP3 http://www.ncbi.nlm.nih.gov/gene/9967 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004427 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TINP1 http://www.ncbi.nlm.nih.gov/gene/10412 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004428 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TJP2 http://www.ncbi.nlm.nih.gov/gene/9414 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004429 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TMC7 http://www.ncbi.nlm.nih.gov/gene/79905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004430 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TMED7 http://www.ncbi.nlm.nih.gov/gene/353376 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004431 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TMEM161B http://www.ncbi.nlm.nih.gov/gene/153396 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004432 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TMEM164 http://www.ncbi.nlm.nih.gov/gene/84187 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004433 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TMEM170A http://www.ncbi.nlm.nih.gov/gene/124491 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004434 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TMEM181 http://www.ncbi.nlm.nih.gov/gene/57583 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004435 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TMEM38B http://www.ncbi.nlm.nih.gov/gene/55151 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004436 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TMEM80 http://www.ncbi.nlm.nih.gov/gene/283232 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004437 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TMEM87A http://www.ncbi.nlm.nih.gov/gene/25963 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004438 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TMTC3 http://www.ncbi.nlm.nih.gov/gene/160418 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004439 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TNKS1BP1 http://www.ncbi.nlm.nih.gov/gene/85456 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004440 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TNKS2 http://www.ncbi.nlm.nih.gov/gene/80351 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004441 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TNRC6A http://www.ncbi.nlm.nih.gov/gene/27327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004442 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TOLLIP http://www.ncbi.nlm.nih.gov/gene/54472 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004443 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TOMM20 http://www.ncbi.nlm.nih.gov/gene/100129272 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004444 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TOR1AIP2 http://www.ncbi.nlm.nih.gov/gene/163590 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004445 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TP53INP1 http://www.ncbi.nlm.nih.gov/gene/94241 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004446 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TRAK1 http://www.ncbi.nlm.nih.gov/gene/22906 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004447 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TRIB1 http://www.ncbi.nlm.nih.gov/gene/10221 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004448 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TRIM23 http://www.ncbi.nlm.nih.gov/gene/373 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004449 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TRPS1 http://www.ncbi.nlm.nih.gov/gene/7227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004450 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TSNAX http://www.ncbi.nlm.nih.gov/gene/7257 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004451 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TWISTNB http://www.ncbi.nlm.nih.gov/gene/221830 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004452 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA TXNDC9 http://www.ncbi.nlm.nih.gov/gene/10190 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004453 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA UBA3 http://www.ncbi.nlm.nih.gov/gene/9039 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004454 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA UBE2D3 http://www.ncbi.nlm.nih.gov/gene/100037280 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004455 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA UBE2R2 http://www.ncbi.nlm.nih.gov/gene/54926 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004456 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA UBN2 http://www.ncbi.nlm.nih.gov/gene/254048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004457 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA UBR1 http://www.ncbi.nlm.nih.gov/gene/197131 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004458 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA USP31 http://www.ncbi.nlm.nih.gov/gene/57478 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004459 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA USP33 http://www.ncbi.nlm.nih.gov/gene/23032 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004460 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA USP42 http://www.ncbi.nlm.nih.gov/gene/84132 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004461 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA USP47 http://www.ncbi.nlm.nih.gov/gene/55031 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004462 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA USP6NL http://www.ncbi.nlm.nih.gov/gene/9712 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004463 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA UTP23 http://www.ncbi.nlm.nih.gov/gene/84294 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004464 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA VAMP3 http://www.ncbi.nlm.nih.gov/gene/9341 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004465 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA VIL2 http://www.ncbi.nlm.nih.gov/gene/7430 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004466 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA WDR32 http://www.ncbi.nlm.nih.gov/gene/79269 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004467 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA WDR43 http://www.ncbi.nlm.nih.gov/gene/23160 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004468 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA WDR6 http://www.ncbi.nlm.nih.gov/gene/11180 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004469 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA WEE1 http://www.ncbi.nlm.nih.gov/gene/7465 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004470 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA WHSC1L1 http://www.ncbi.nlm.nih.gov/gene/54904 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004471 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA WNK1 http://www.ncbi.nlm.nih.gov/gene/65125 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004472 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA XIAP http://www.ncbi.nlm.nih.gov/gene/331 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004473 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA XPO1 http://www.ncbi.nlm.nih.gov/gene/7514 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004474 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA XRCC5 http://www.ncbi.nlm.nih.gov/gene/7520 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004475 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA YY1 http://www.ncbi.nlm.nih.gov/gene/7528 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004476 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ZBTB38 http://www.ncbi.nlm.nih.gov/gene/253461 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004477 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ZBTB44 http://www.ncbi.nlm.nih.gov/gene/29068 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004478 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ZBTB6 http://www.ncbi.nlm.nih.gov/gene/10773 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004479 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ZC3H4 http://www.ncbi.nlm.nih.gov/gene/23211 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004480 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ZFAND1 http://www.ncbi.nlm.nih.gov/gene/79752 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004481 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ZHX1 http://www.ncbi.nlm.nih.gov/gene/11244 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004482 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ZMAT3 http://www.ncbi.nlm.nih.gov/gene/64393 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004483 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ZMYM2 http://www.ncbi.nlm.nih.gov/gene/7750 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004484 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ZMYND8 http://www.ncbi.nlm.nih.gov/gene/23613 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004485 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ZNF12 http://www.ncbi.nlm.nih.gov/gene/7559 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004486 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ZNF192 http://www.ncbi.nlm.nih.gov/gene/7745 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004487 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ZNF295 http://www.ncbi.nlm.nih.gov/gene/49854 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004488 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ZNF655 http://www.ncbi.nlm.nih.gov/gene/79027 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004489 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ZNF738 http://www.ncbi.nlm.nih.gov/gene/148203 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004490 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ZNF747 http://www.ncbi.nlm.nih.gov/gene/65988 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004491 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ZNF772 http://www.ncbi.nlm.nih.gov/gene/400720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004492 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(ebv-mir-bart22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 BC-1 - Host mRNA ZNF91 http://www.ncbi.nlm.nih.gov/gene/7644 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004493 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(BART-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 - - Host Protein DAZAP2 http://www.ncbi.nlm.nih.gov/gene/9802 - PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 For each of them, direct interactions between 3'UTR and EBV miRNAs were confirmed by luciferase assay but no functional assay has been performed so far (Table 2).Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation (PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP) or RNA immunoprecipitation and microarray (RIP-Chip) techniques. Validation of these targets was done using luciferase reporter assays. VHID00004494 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(BART-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 - - Host Protein IPO7 http://www.ncbi.nlm.nih.gov/gene/10527 - PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 For each of them, direct interactions between 3'UTR and EBV miRNAs were confirmed by luciferase assay but no functional assay has been performed so far (Table 2).Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation (PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP) or RNA immunoprecipitation and microarray (RIP-Chip) techniques. Validation of these targets was done using luciferase reporter assays. VHID00004495 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(BART-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 - - Host Protein PDE7A http://www.ncbi.nlm.nih.gov/gene/5150 - PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 For each of them, direct interactions between 3'UTR and EBV miRNAs were confirmed by luciferase assay but no functional assay has been performed so far (Table 2).Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation (PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP) or RNA immunoprecipitation and microarray (RIP-Chip) techniques. Validation of these targets was done using luciferase reporter assays. VHID00004496 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(BART3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 - - Host mRNA CLEC2D http://www.ncbi.nlm.nih.gov/gene/29121 - PAR-CLIP. 23170179 In addition, CLEC2D/LLT1 was identified as a target of BART1 and BART3 by PAR-CLIP. VHID00004497 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-miR-BART3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 human B cells - Host Protein IPO7 http://www.ncbi.nlm.nih.gov/gene/10527 Downregulation Luciferase assays, RISC immunoprecipitation assay.TaqMan PCR.RIP-Chip analysis. 20413099 Luciferase assays with sensor vectors carrying the 3'UTRs of TOMM22 and IPO7 demonstrated significant repression by ebv-miR-BART16 and ebv-miR-BART3, respectively. VHID00004498 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA ACTR2 http://www.ncbi.nlm.nih.gov/gene/10097 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004499 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA ADRB1 http://www.ncbi.nlm.nih.gov/gene/153 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004500 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA ALS2 http://www.ncbi.nlm.nih.gov/gene/57679 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004501 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA ANKRD13C http://www.ncbi.nlm.nih.gov/gene/81573 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004502 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA ANLN http://www.ncbi.nlm.nih.gov/gene/54443 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004503 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA ARFGEF2 http://www.ncbi.nlm.nih.gov/gene/10564 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004504 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA ARL5B http://www.ncbi.nlm.nih.gov/gene/221079 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004505 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA ASB8 http://www.ncbi.nlm.nih.gov/gene/140461 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004506 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA ASPH http://www.ncbi.nlm.nih.gov/gene/444 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004507 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA BCL7A http://www.ncbi.nlm.nih.gov/gene/605 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004508 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA BIVM http://www.ncbi.nlm.nih.gov/gene/54841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004509 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA BNIP2 http://www.ncbi.nlm.nih.gov/gene/663 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004510 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA BRD4 http://www.ncbi.nlm.nih.gov/gene/23476 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004511 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA BRE http://www.ncbi.nlm.nih.gov/gene/9577 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004512 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA BRMS1L http://www.ncbi.nlm.nih.gov/gene/84312 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004513 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA C11orf24 http://www.ncbi.nlm.nih.gov/gene/53838 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004514 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA C12orf65 http://www.ncbi.nlm.nih.gov/gene/91574 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004515 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA C18orf25 http://www.ncbi.nlm.nih.gov/gene/147339 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004516 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA C1orf107 http://www.ncbi.nlm.nih.gov/gene/27042 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004517 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA C20orf112 http://www.ncbi.nlm.nih.gov/gene/140688 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004518 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA C21orf91 http://www.ncbi.nlm.nih.gov/gene/54149 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004519 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA C9orf126 http://www.ncbi.nlm.nih.gov/gene/286205 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004520 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA CAMSAP1L1 http://www.ncbi.nlm.nih.gov/gene/23271 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004521 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA CAND1 http://www.ncbi.nlm.nih.gov/gene/55832 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004522 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA CASP10 http://www.ncbi.nlm.nih.gov/gene/843 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004523 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA CASP3 http://www.ncbi.nlm.nih.gov/gene/836 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004524 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA CBX5 http://www.ncbi.nlm.nih.gov/gene/23468 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004525 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA CCDC117 http://www.ncbi.nlm.nih.gov/gene/150275 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004526 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA CDCA4 http://www.ncbi.nlm.nih.gov/gene/55038 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004527 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA CDK6 http://www.ncbi.nlm.nih.gov/gene/1021 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004528 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA COMMD2 http://www.ncbi.nlm.nih.gov/gene/51122 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004529 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA CSDE1 http://www.ncbi.nlm.nih.gov/gene/7812 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004530 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA CUL5 http://www.ncbi.nlm.nih.gov/gene/8065 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004531 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA CUX1 http://www.ncbi.nlm.nih.gov/gene/1523 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004532 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA DAZAP2 http://www.ncbi.nlm.nih.gov/gene/9802 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004533 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA DCC http://www.ncbi.nlm.nih.gov/gene/1630 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004534 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA DDHD2 http://www.ncbi.nlm.nih.gov/gene/23259 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004535 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA DDX5 http://www.ncbi.nlm.nih.gov/gene/1655 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004536 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA DIDO1 http://www.ncbi.nlm.nih.gov/gene/11083 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004537 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA DNAJC27 http://www.ncbi.nlm.nih.gov/gene/51277 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004538 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA DPP8 http://www.ncbi.nlm.nih.gov/gene/54878 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004539 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA EAF1 http://www.ncbi.nlm.nih.gov/gene/85403 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004540 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA EIF4G1 http://www.ncbi.nlm.nih.gov/gene/1981 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004541 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA ENC1 http://www.ncbi.nlm.nih.gov/gene/8507 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004542 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA EP300 http://www.ncbi.nlm.nih.gov/gene/2033 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004543 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA EPRS http://www.ncbi.nlm.nih.gov/gene/2058 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004544 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA EXOC5 http://www.ncbi.nlm.nih.gov/gene/10640 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004545 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA FAM126B http://www.ncbi.nlm.nih.gov/gene/285172 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004546 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA FAM136A http://www.ncbi.nlm.nih.gov/gene/84908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004547 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA FAM46C http://www.ncbi.nlm.nih.gov/gene/54855 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004548 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA FBXW7 http://www.ncbi.nlm.nih.gov/gene/55294 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004549 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA FEM1A http://www.ncbi.nlm.nih.gov/gene/55527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004550 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA FEM1B http://www.ncbi.nlm.nih.gov/gene/10116 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004551 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA FOXK1 http://www.ncbi.nlm.nih.gov/gene/221937 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004552 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA FOXK2 http://www.ncbi.nlm.nih.gov/gene/3607 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004553 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA GNAQ http://www.ncbi.nlm.nih.gov/gene/2776 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004554 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA GOLGA1 http://www.ncbi.nlm.nih.gov/gene/2800 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004555 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA GOLGA8A http://www.ncbi.nlm.nih.gov/gene/440270 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004556 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA GPATCH3 http://www.ncbi.nlm.nih.gov/gene/63906 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004557 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA HBP1 http://www.ncbi.nlm.nih.gov/gene/26959 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004558 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA HIPK1 http://www.ncbi.nlm.nih.gov/gene/204851 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004559 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA HMGCS1 http://www.ncbi.nlm.nih.gov/gene/3157 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004560 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA HUWE1 http://www.ncbi.nlm.nih.gov/gene/10075 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004561 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA IFNAR2 http://www.ncbi.nlm.nih.gov/gene/3455 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004562 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA IL16 http://www.ncbi.nlm.nih.gov/gene/3603 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004563 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA IPO7 http://www.ncbi.nlm.nih.gov/gene/10527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004564 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA IRF1 http://www.ncbi.nlm.nih.gov/gene/3659 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004565 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA KLF12 http://www.ncbi.nlm.nih.gov/gene/11278 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004566 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA KLF2 http://www.ncbi.nlm.nih.gov/gene/10365 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004567 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA KLF6 http://www.ncbi.nlm.nih.gov/gene/1316 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004568 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA KPNA4 http://www.ncbi.nlm.nih.gov/gene/3840 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004569 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA KPNA5 http://www.ncbi.nlm.nih.gov/gene/3841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004570 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA LIN7C http://www.ncbi.nlm.nih.gov/gene/55327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004571 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA MAPK1 http://www.ncbi.nlm.nih.gov/gene/5594 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004572 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA MBTD1 http://www.ncbi.nlm.nih.gov/gene/54799 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004573 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA MBTPS2 http://www.ncbi.nlm.nih.gov/gene/51360 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004574 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA MGA http://www.ncbi.nlm.nih.gov/gene/23269 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004575 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA MTMR1 http://www.ncbi.nlm.nih.gov/gene/8776 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004576 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA NAP1L5 http://www.ncbi.nlm.nih.gov/gene/266812 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004577 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA NCOA3 http://www.ncbi.nlm.nih.gov/gene/8202 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004578 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA NDRG1 http://www.ncbi.nlm.nih.gov/gene/10397 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004579 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA NFYC http://www.ncbi.nlm.nih.gov/gene/4802 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004580 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA NUDCD1 http://www.ncbi.nlm.nih.gov/gene/84955 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004581 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA PANK1 http://www.ncbi.nlm.nih.gov/gene/53354 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004582 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA PARD6B http://www.ncbi.nlm.nih.gov/gene/84612 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004583 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA PHC3 http://www.ncbi.nlm.nih.gov/gene/80012 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004584 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA PHTF2 http://www.ncbi.nlm.nih.gov/gene/57157 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004585 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA PIK3C3 http://www.ncbi.nlm.nih.gov/gene/5289 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004586 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA PIK3CB http://www.ncbi.nlm.nih.gov/gene/5291 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004587 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA PLEC1 http://www.ncbi.nlm.nih.gov/gene/5339 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004588 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA POLR1D http://www.ncbi.nlm.nih.gov/gene/51082 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004589 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA POU2F1 http://www.ncbi.nlm.nih.gov/gene/5451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004590 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA PPARA http://www.ncbi.nlm.nih.gov/gene/5465 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004591 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA PPP3CA http://www.ncbi.nlm.nih.gov/gene/5530 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004592 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA PPP3R1 http://www.ncbi.nlm.nih.gov/gene/5534 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004593 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA PRDM1 http://www.ncbi.nlm.nih.gov/gene/639 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004594 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA PRICKLE2 http://www.ncbi.nlm.nih.gov/gene/166336 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004595 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA PSMA4 http://www.ncbi.nlm.nih.gov/gene/5685 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004596 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA PSMD11 http://www.ncbi.nlm.nih.gov/gene/5717 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004597 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA PSMD5 http://www.ncbi.nlm.nih.gov/gene/5711 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004598 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA PTAR1 http://www.ncbi.nlm.nih.gov/gene/375743 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004599 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA PTPN4 http://www.ncbi.nlm.nih.gov/gene/5775 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004600 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA QSER1 http://www.ncbi.nlm.nih.gov/gene/79832 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004601 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA RAD21 http://www.ncbi.nlm.nih.gov/gene/5885 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004602 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA RASSF5 http://www.ncbi.nlm.nih.gov/gene/83593 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004603 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA RBMS2P http://www.ncbi.nlm.nih.gov/gene/643427 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004604 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA RC3H1 http://www.ncbi.nlm.nih.gov/gene/149041 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004605 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA RCOR3 http://www.ncbi.nlm.nih.gov/gene/55758 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004606 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA RNF160 http://www.ncbi.nlm.nih.gov/gene/26046 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004607 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA ROD1 http://www.ncbi.nlm.nih.gov/gene/9991 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004608 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA RPIA http://www.ncbi.nlm.nih.gov/gene/22934 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004609 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA RPL22 http://www.ncbi.nlm.nih.gov/gene/402100 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004610 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA RPS6KB1 http://www.ncbi.nlm.nih.gov/gene/6198 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004611 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA SEC24A http://www.ncbi.nlm.nih.gov/gene/10802 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004612 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA SEPSECS http://www.ncbi.nlm.nih.gov/gene/51091 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004613 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA SERBP1 http://www.ncbi.nlm.nih.gov/gene/26135 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004614 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA SERTAD2 http://www.ncbi.nlm.nih.gov/gene/9792 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004615 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA SETDB1 http://www.ncbi.nlm.nih.gov/gene/9869 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004616 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA SFRS12 http://www.ncbi.nlm.nih.gov/gene/140890 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004617 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA SH3BGRL2 http://www.ncbi.nlm.nih.gov/gene/83699 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004618 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA SH3BP2 http://www.ncbi.nlm.nih.gov/gene/6452 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004619 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA SHISA5 http://www.ncbi.nlm.nih.gov/gene/51246 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004620 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA SLC16A1 http://www.ncbi.nlm.nih.gov/gene/6566 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004621 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA SMARCAD1 http://www.ncbi.nlm.nih.gov/gene/56916 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004622 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA SMARCC1 http://www.ncbi.nlm.nih.gov/gene/6599 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004623 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA SMU1 http://www.ncbi.nlm.nih.gov/gene/55234 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004624 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA SOCS6 http://www.ncbi.nlm.nih.gov/gene/9306 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004625 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA SSR3 http://www.ncbi.nlm.nih.gov/gene/6747 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004626 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA STIM2 http://www.ncbi.nlm.nih.gov/gene/57620 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004627 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA STK38 http://www.ncbi.nlm.nih.gov/gene/11329 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004628 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA STK38L http://www.ncbi.nlm.nih.gov/gene/23012 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004629 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA STRN http://www.ncbi.nlm.nih.gov/gene/6801 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004630 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA SYNJ2BP http://www.ncbi.nlm.nih.gov/gene/55333 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004631 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA TAF13 http://www.ncbi.nlm.nih.gov/gene/6884 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004632 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA TAF2 http://www.ncbi.nlm.nih.gov/gene/6873 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004633 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA TBL1XR1 http://www.ncbi.nlm.nih.gov/gene/79718 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004634 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA TET1 http://www.ncbi.nlm.nih.gov/gene/80312 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004635 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA TET3 http://www.ncbi.nlm.nih.gov/gene/200424 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004636 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA THOC7 http://www.ncbi.nlm.nih.gov/gene/80145 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004637 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA TLE3 http://www.ncbi.nlm.nih.gov/gene/7090 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004638 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA TMEM111 http://www.ncbi.nlm.nih.gov/gene/55831 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004639 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA TSEN15 http://www.ncbi.nlm.nih.gov/gene/116461 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004640 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA UAP1L1 http://www.ncbi.nlm.nih.gov/gene/91373 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004641 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA UBE2Z http://www.ncbi.nlm.nih.gov/gene/65264 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004642 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA UBE4A http://www.ncbi.nlm.nih.gov/gene/9354 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004643 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA USP42 http://www.ncbi.nlm.nih.gov/gene/84132 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004644 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA UTP14C http://www.ncbi.nlm.nih.gov/gene/9724 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004645 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA WDR26 http://www.ncbi.nlm.nih.gov/gene/80232 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004646 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA XPO1 http://www.ncbi.nlm.nih.gov/gene/7514 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004647 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA ZMYM2 http://www.ncbi.nlm.nih.gov/gene/7750 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004648 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA ZMYM4 http://www.ncbi.nlm.nih.gov/gene/9202 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004649 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA ZNF282 http://www.ncbi.nlm.nih.gov/gene/8427 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004650 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA ZNF498 http://www.ncbi.nlm.nih.gov/gene/221785 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004651 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA ZNF644 http://www.ncbi.nlm.nih.gov/gene/84146 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004652 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 BC-1 - Host mRNA ZNF714 http://www.ncbi.nlm.nih.gov/gene/148206 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004653 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA AIM1 http://www.ncbi.nlm.nih.gov/gene/202 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004654 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA APAF1 http://www.ncbi.nlm.nih.gov/gene/317 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004655 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA ARFGEF2 http://www.ncbi.nlm.nih.gov/gene/10564 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004656 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA ARHGAP11A http://www.ncbi.nlm.nih.gov/gene/89839 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004657 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA ARL5B http://www.ncbi.nlm.nih.gov/gene/221079 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004658 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA AURKC http://www.ncbi.nlm.nih.gov/gene/6795 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004659 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA BASP1 http://www.ncbi.nlm.nih.gov/gene/10409 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004660 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA BNIP2 http://www.ncbi.nlm.nih.gov/gene/663 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004661 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA BRD4 http://www.ncbi.nlm.nih.gov/gene/23476 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004662 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA BRE http://www.ncbi.nlm.nih.gov/gene/9577 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004663 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA BRWD1 http://www.ncbi.nlm.nih.gov/gene/54014 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004664 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA C11orf24 http://www.ncbi.nlm.nih.gov/gene/53838 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004665 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA C12orf30 http://www.ncbi.nlm.nih.gov/gene/80018 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004666 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA C12orf65 http://www.ncbi.nlm.nih.gov/gene/91574 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004667 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA C18orf25 http://www.ncbi.nlm.nih.gov/gene/147339 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004668 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA C20orf112 http://www.ncbi.nlm.nih.gov/gene/140688 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004669 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA C21orf91 http://www.ncbi.nlm.nih.gov/gene/54149 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004670 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA CAND1 http://www.ncbi.nlm.nih.gov/gene/55832 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004671 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA CBX5 http://www.ncbi.nlm.nih.gov/gene/23468 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004672 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA CCDC117 http://www.ncbi.nlm.nih.gov/gene/150275 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004673 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA CDK6 http://www.ncbi.nlm.nih.gov/gene/1021 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004674 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA CHEK1 http://www.ncbi.nlm.nih.gov/gene/1111 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004675 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA CNOT1 http://www.ncbi.nlm.nih.gov/gene/23019 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004676 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA CUL5 http://www.ncbi.nlm.nih.gov/gene/8065 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004677 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA CUX1 http://www.ncbi.nlm.nih.gov/gene/1523 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004678 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA DAPK1 http://www.ncbi.nlm.nih.gov/gene/1612 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004679 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA DAZAP2 http://www.ncbi.nlm.nih.gov/gene/9802 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004680 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA DDX5 http://www.ncbi.nlm.nih.gov/gene/1655 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004681 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA DNAJA1 http://www.ncbi.nlm.nih.gov/gene/3301 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004682 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA EAF1 http://www.ncbi.nlm.nih.gov/gene/85403 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004683 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA EIF4G1 http://www.ncbi.nlm.nih.gov/gene/1981 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004684 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA EPRS http://www.ncbi.nlm.nih.gov/gene/2058 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004685 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA FAM179B http://www.ncbi.nlm.nih.gov/gene/23116 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004686 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA FEM1B http://www.ncbi.nlm.nih.gov/gene/10116 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004687 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA FMNL3 http://www.ncbi.nlm.nih.gov/gene/91010 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004688 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA FNDC3A http://www.ncbi.nlm.nih.gov/gene/22862 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004689 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA FOXK2 http://www.ncbi.nlm.nih.gov/gene/3607 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004690 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA GOLGA1 http://www.ncbi.nlm.nih.gov/gene/2800 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004691 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA GOLGA8A http://www.ncbi.nlm.nih.gov/gene/440270 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004692 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA HIPK1 http://www.ncbi.nlm.nih.gov/gene/204851 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004693 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA HLA-C http://www.ncbi.nlm.nih.gov/gene/3106 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004694 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA HMGCS1 http://www.ncbi.nlm.nih.gov/gene/3157 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004695 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA HUWE1 http://www.ncbi.nlm.nih.gov/gene/10075 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004696 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA IFNAR2 http://www.ncbi.nlm.nih.gov/gene/3455 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004697 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA IPO7 http://www.ncbi.nlm.nih.gov/gene/10527 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004698 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA IRF1 http://www.ncbi.nlm.nih.gov/gene/3659 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004699 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA ITPRIPL2 http://www.ncbi.nlm.nih.gov/gene/162073 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004700 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA KLF12 http://www.ncbi.nlm.nih.gov/gene/11278 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004701 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA KLF2 http://www.ncbi.nlm.nih.gov/gene/10365 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004702 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA KTI12 http://www.ncbi.nlm.nih.gov/gene/112970 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004703 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA LDHB http://www.ncbi.nlm.nih.gov/gene/3945 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004704 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA MBTD1 http://www.ncbi.nlm.nih.gov/gene/54799 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004705 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA MGA http://www.ncbi.nlm.nih.gov/gene/23269 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004706 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA MKI67 http://www.ncbi.nlm.nih.gov/gene/4288 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004707 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA NAP1L5 http://www.ncbi.nlm.nih.gov/gene/266812 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004708 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA NCOA3 http://www.ncbi.nlm.nih.gov/gene/8202 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004709 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA NFYC http://www.ncbi.nlm.nih.gov/gene/4802 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004710 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA PANK1 http://www.ncbi.nlm.nih.gov/gene/53354 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004711 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA PANK3 http://www.ncbi.nlm.nih.gov/gene/79646 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004712 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA PARD6B http://www.ncbi.nlm.nih.gov/gene/84612 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004713 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA PEG10 http://www.ncbi.nlm.nih.gov/gene/23089 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004714 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA PLXNC1 http://www.ncbi.nlm.nih.gov/gene/10154 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004715 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA POLR1D http://www.ncbi.nlm.nih.gov/gene/51082 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004716 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA POU2F1 http://www.ncbi.nlm.nih.gov/gene/5451 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004717 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA PPARGC1B http://www.ncbi.nlm.nih.gov/gene/133522 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004718 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA PPP3CA http://www.ncbi.nlm.nih.gov/gene/5530 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004719 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA PSMA4 http://www.ncbi.nlm.nih.gov/gene/5685 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004720 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA PSMB4 http://www.ncbi.nlm.nih.gov/gene/5692 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004721 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA PSMD11 http://www.ncbi.nlm.nih.gov/gene/5717 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004722 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA PSMD5 http://www.ncbi.nlm.nih.gov/gene/5711 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004723 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA PTAR1 http://www.ncbi.nlm.nih.gov/gene/375743 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004724 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA QSER1 http://www.ncbi.nlm.nih.gov/gene/79832 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004725 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA RPS6KB1 http://www.ncbi.nlm.nih.gov/gene/6198 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004726 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA SAMD9L http://www.ncbi.nlm.nih.gov/gene/219285 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004727 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA SCMH1 http://www.ncbi.nlm.nih.gov/gene/22955 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004728 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA SEC23A http://www.ncbi.nlm.nih.gov/gene/10484 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004729 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA SEC31A http://www.ncbi.nlm.nih.gov/gene/22872 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004730 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA SERINC3 http://www.ncbi.nlm.nih.gov/gene/10955 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004731 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA SFRS12 http://www.ncbi.nlm.nih.gov/gene/140890 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004732 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA SH3BP2 http://www.ncbi.nlm.nih.gov/gene/6452 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004733 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA SH3PXD2A http://www.ncbi.nlm.nih.gov/gene/9644 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004734 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA SLC16A1 http://www.ncbi.nlm.nih.gov/gene/6566 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004735 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA SMARCAD1 http://www.ncbi.nlm.nih.gov/gene/56916 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004736 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA SMU1 http://www.ncbi.nlm.nih.gov/gene/55234 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004737 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA SOCS6 http://www.ncbi.nlm.nih.gov/gene/9306 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004738 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA STEAP3 http://www.ncbi.nlm.nih.gov/gene/55240 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004739 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA STIM2 http://www.ncbi.nlm.nih.gov/gene/57620 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004740 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA STK38 http://www.ncbi.nlm.nih.gov/gene/11329 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004741 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA STK38L http://www.ncbi.nlm.nih.gov/gene/23012 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004742 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA STRN http://www.ncbi.nlm.nih.gov/gene/6801 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004743 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA TAF13 http://www.ncbi.nlm.nih.gov/gene/6884 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004744 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA TBC1D23 http://www.ncbi.nlm.nih.gov/gene/55773 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004745 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA TBL1XR1 http://www.ncbi.nlm.nih.gov/gene/79718 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004746 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA TCP1 http://www.ncbi.nlm.nih.gov/gene/400013 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004747 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA TET3 http://www.ncbi.nlm.nih.gov/gene/200424 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004748 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA THOC7 http://www.ncbi.nlm.nih.gov/gene/80145 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004749 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA TIMM17A http://www.ncbi.nlm.nih.gov/gene/10440 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004750 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA TLE3 http://www.ncbi.nlm.nih.gov/gene/7090 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004751 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA TUBA1 http://www.ncbi.nlm.nih.gov/gene/7277 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004752 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA UAP1L1 http://www.ncbi.nlm.nih.gov/gene/91373 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004753 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA UBE2Z http://www.ncbi.nlm.nih.gov/gene/65264 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004754 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA USP47 http://www.ncbi.nlm.nih.gov/gene/55031 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004755 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA UTP14C http://www.ncbi.nlm.nih.gov/gene/9724 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004756 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA WDR26 http://www.ncbi.nlm.nih.gov/gene/80232 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004757 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA ZC3H12C http://www.ncbi.nlm.nih.gov/gene/85463 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004758 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA ZC3H4 http://www.ncbi.nlm.nih.gov/gene/23211 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004759 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA ZFP3 http://www.ncbi.nlm.nih.gov/gene/124961 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004760 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA ZMYM2 http://www.ncbi.nlm.nih.gov/gene/7750 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004761 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA ZNF644 http://www.ncbi.nlm.nih.gov/gene/84146 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004762 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA ZNF714 http://www.ncbi.nlm.nih.gov/gene/148206 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004763 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(ebv-mir-bart3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 Lymphoblastoid cell lines - Host mRNA ZSCAN25(ZNF498) - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004764 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(miR-BART3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 - - Host Protein IPO7 http://www.ncbi.nlm.nih.gov/gene/10527 Downregulation Luciferase assays, RISC immunoprecipitation assay.TaqMan PCR.RIP-Chip analysis. 22100165 A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs.Luciferase assays with sensor vectors carrying the 30UTRs of TOMM22 and IPO7 demonstrated significant repression by ebv-miR-BART16 and ebv-miR-BART3, respectively. VHID00004765 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(miR-BART3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 293T cells - Host Protein NFKB1 http://www.ncbi.nlm.nih.gov/gene/4790 Downregulation luciferase reporter assays, photoactivatable cross-linking and immunoprecipitation(PAR-CLIP), and deep sequencing and qRT-PCR. 24257599 Indeed, miR-BART3, miR-BART5, and miR-BART16 each inhibited NFKB activation when cotransfected with full-length LMP1.These data demonstrate that miR-rL1-8 can functionally substitute for miRBART5 and that miR-BART5 and miR-BART16 negatively regulate NFKB signaling by directly targeting the LMP1 3'UTR. VHID00004766 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(miR-BART3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 epithelial cell lines - Host Protein BCL2L11(BimEL) http://www.ncbi.nlm.nih.gov/gene/396632 Downregulation Northern Blot analysis and quantitative RT-PCR, Western Blot analysis, Microarray analysis, ciferase Assays. 21333317 Analysis of the BimEL protein levels in cells expressing the miRNAs revealed that its expression was affected by several of the individual miRNAs with cell lines expressing miR-BART1, 3, 9, 11 and 12 all having decreased BimEL levels (Figure 6B and C). VHID00004767 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(miR-BART3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 epithelial cell lines - Host mRNA BCL2L11(BIM) http://www.ncbi.nlm.nih.gov/gene/396632 Downregulation Northern Blot analysis and quantitative RT-PCR, Western Blot analysis, Microarray analysis, ciferase Assays. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VHID00004768 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(mir-BART3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 B cell lymphomagenesis - Host mRNA DICER1 http://www.ncbi.nlm.nih.gov/gene/23405 - Western Blotting, Northern Blotting, Luciferase Reporter Assay. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VHID00004769 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(mir-BART3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 B cell lymphomagenesis - Host mRNA MICB http://www.ncbi.nlm.nih.gov/gene/4277 - Western Blotting, Northern Blotting, Luciferase Reporter Assay. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VHID00004770 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(pre-miR-BART3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 NPC cells - Host Protein INTS6(DICE1) http://www.ncbi.nlm.nih.gov/gene/26512 Downregulation Microarray analysis. 23280823 Taken together, our findings suggest that EBV encoded miR-BART3* miRNA targets DICE1 tumor suppressor to promote cellular growth and transformation in NPC.Enforced expression of miR-BART3* or its precursor pre-miR-BART3 led to down-regulation of endogenous DICE1 expression. VHID00004771 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(BART4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 - - Host Protein BACH1 http://www.ncbi.nlm.nih.gov/gene/571 - PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 For each of them, direct interactions between 3'UTR and EBV miRNAs were confirmed by luciferase assay but no functional assay has been performed so far (Table 2).Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation (PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP) or RNA immunoprecipitation and microarray (RIP-Chip) techniques. Validation of these targets was done using luciferase reporter assays. VHID00004772 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA MARCH5 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004773 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA ABL2 http://www.ncbi.nlm.nih.gov/gene/27 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004774 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA ADPGK http://www.ncbi.nlm.nih.gov/gene/83440 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004775 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA ATP11B http://www.ncbi.nlm.nih.gov/gene/23200 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004776 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA ATP6V1C1 http://www.ncbi.nlm.nih.gov/gene/528 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004777 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA ATPAF1 http://www.ncbi.nlm.nih.gov/gene/64756 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004778 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA BRWD1 http://www.ncbi.nlm.nih.gov/gene/54014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004779 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA C13orf23 http://www.ncbi.nlm.nih.gov/gene/80209 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004780 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA C1orf55 http://www.ncbi.nlm.nih.gov/gene/163859 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004781 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA C21orf91 http://www.ncbi.nlm.nih.gov/gene/54149 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004782 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA C7orf11 http://www.ncbi.nlm.nih.gov/gene/136647 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004783 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA CCDC14 http://www.ncbi.nlm.nih.gov/gene/64770 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004784 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004785 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA CPEB3 http://www.ncbi.nlm.nih.gov/gene/22849 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004786 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA EIF4A2 http://www.ncbi.nlm.nih.gov/gene/286512 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004787 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA ELF1 http://www.ncbi.nlm.nih.gov/gene/1997 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004788 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA ELK4 http://www.ncbi.nlm.nih.gov/gene/2005 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004789 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA FAM168B http://www.ncbi.nlm.nih.gov/gene/130074 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004790 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA FBXO28 http://www.ncbi.nlm.nih.gov/gene/23219 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004791 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA FEM1C http://www.ncbi.nlm.nih.gov/gene/56929 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004792 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA G3BP1 http://www.ncbi.nlm.nih.gov/gene/10146 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004793 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA GAB1 http://www.ncbi.nlm.nih.gov/gene/2549 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004794 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA GLCCI1 http://www.ncbi.nlm.nih.gov/gene/113263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004795 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA GM2A http://www.ncbi.nlm.nih.gov/gene/2760 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004796 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA IGF2BP3 http://www.ncbi.nlm.nih.gov/gene/10643 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004797 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA JMJD1C http://www.ncbi.nlm.nih.gov/gene/221037 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004798 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA KIAA1826 http://www.ncbi.nlm.nih.gov/gene/84437 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004799 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA KIAA1919 http://www.ncbi.nlm.nih.gov/gene/91749 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004800 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA KLHL15 http://www.ncbi.nlm.nih.gov/gene/80311 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004801 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA LCOR http://www.ncbi.nlm.nih.gov/gene/84458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004802 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA LIX1L http://www.ncbi.nlm.nih.gov/gene/128077 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004803 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA MAP3K2 http://www.ncbi.nlm.nih.gov/gene/10746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004804 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA MAP4K4 http://www.ncbi.nlm.nih.gov/gene/9448 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004805 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA MAPK8 http://www.ncbi.nlm.nih.gov/gene/5599 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004806 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA MARS2 http://www.ncbi.nlm.nih.gov/gene/92935 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004807 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA MAT2B http://www.ncbi.nlm.nih.gov/gene/27430 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004808 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA MDM4 http://www.ncbi.nlm.nih.gov/gene/4194 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004809 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA MIB1 http://www.ncbi.nlm.nih.gov/gene/57534 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004810 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA MSC http://www.ncbi.nlm.nih.gov/gene/9242 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004811 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA NDNL2 http://www.ncbi.nlm.nih.gov/gene/56160 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004812 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA NUPL1 http://www.ncbi.nlm.nih.gov/gene/9818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004813 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA OXR1 http://www.ncbi.nlm.nih.gov/gene/55074 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004814 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA PANK3 http://www.ncbi.nlm.nih.gov/gene/79646 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004815 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA PPP2CA http://www.ncbi.nlm.nih.gov/gene/5515 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004816 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA PPTC7 http://www.ncbi.nlm.nih.gov/gene/160760 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004817 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA RAB11FIP2 http://www.ncbi.nlm.nih.gov/gene/22841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004818 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA RNF34 http://www.ncbi.nlm.nih.gov/gene/80196 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004819 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA SNX1 http://www.ncbi.nlm.nih.gov/gene/6642 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004820 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA STARD4 http://www.ncbi.nlm.nih.gov/gene/134429 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004821 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA STK17B http://www.ncbi.nlm.nih.gov/gene/9262 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004822 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA TECPR1 http://www.ncbi.nlm.nih.gov/gene/25851 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004823 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA TMPO http://www.ncbi.nlm.nih.gov/gene/7112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004824 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA TMTC3 http://www.ncbi.nlm.nih.gov/gene/160418 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004825 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA TRIB1 http://www.ncbi.nlm.nih.gov/gene/10221 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004826 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA TRIM23 http://www.ncbi.nlm.nih.gov/gene/373 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004827 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA UHMK1 http://www.ncbi.nlm.nih.gov/gene/127933 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004828 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA VKORC1L1 http://www.ncbi.nlm.nih.gov/gene/154807 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004829 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA YIPF4 http://www.ncbi.nlm.nih.gov/gene/84272 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004830 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA YIPF5 http://www.ncbi.nlm.nih.gov/gene/81555 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004831 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA ZNF217 http://www.ncbi.nlm.nih.gov/gene/7764 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004832 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA ZNF225 http://www.ncbi.nlm.nih.gov/gene/7768 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004833 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA ZNF451 http://www.ncbi.nlm.nih.gov/gene/26036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004834 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA ZNF551 http://www.ncbi.nlm.nih.gov/gene/90233 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004835 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 BC-1 - Host mRNA ZNF614 http://www.ncbi.nlm.nih.gov/gene/80110 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004836 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA ABL2 http://www.ncbi.nlm.nih.gov/gene/27 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004837 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA ADPGK http://www.ncbi.nlm.nih.gov/gene/83440 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004838 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA ANKRA2 http://www.ncbi.nlm.nih.gov/gene/57763 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004839 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA AP1S2 http://www.ncbi.nlm.nih.gov/gene/8905 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004840 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA ARID1A http://www.ncbi.nlm.nih.gov/gene/8289 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004841 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA C13orf23 http://www.ncbi.nlm.nih.gov/gene/80209 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004842 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA C1orf55 http://www.ncbi.nlm.nih.gov/gene/163859 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004843 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA C21orf91 http://www.ncbi.nlm.nih.gov/gene/54149 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004844 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA C6orf89 http://www.ncbi.nlm.nih.gov/gene/221477 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004845 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA C7orf11 http://www.ncbi.nlm.nih.gov/gene/136647 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004846 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA CCDC14 http://www.ncbi.nlm.nih.gov/gene/64770 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004847 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004848 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA DNAH17 http://www.ncbi.nlm.nih.gov/gene/8632 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004849 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA ELF1 http://www.ncbi.nlm.nih.gov/gene/1997 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004850 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA EPSTI1 http://www.ncbi.nlm.nih.gov/gene/94240 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004851 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA FAM175B http://www.ncbi.nlm.nih.gov/gene/23172 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004852 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA FAM49B http://www.ncbi.nlm.nih.gov/gene/51571 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004853 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA FBXO28 http://www.ncbi.nlm.nih.gov/gene/23219 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004854 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA G3BP1 http://www.ncbi.nlm.nih.gov/gene/10146 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004855 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA GPD2 http://www.ncbi.nlm.nih.gov/gene/2820 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004856 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA HIATL1 http://www.ncbi.nlm.nih.gov/gene/84641 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004857 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA HUWE1 http://www.ncbi.nlm.nih.gov/gene/10075 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004858 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA IFNGR2 http://www.ncbi.nlm.nih.gov/gene/3460 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004859 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA IGJ http://www.ncbi.nlm.nih.gov/gene/3512 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004860 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA KIAA1429 http://www.ncbi.nlm.nih.gov/gene/25962 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004861 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA KIAA1826 http://www.ncbi.nlm.nih.gov/gene/84437 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004862 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA KIAA1919 http://www.ncbi.nlm.nih.gov/gene/91749 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004863 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA LCOR http://www.ncbi.nlm.nih.gov/gene/84458 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004864 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA LIX1L http://www.ncbi.nlm.nih.gov/gene/128077 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004865 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA MAP3K2 http://www.ncbi.nlm.nih.gov/gene/10746 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004866 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA MARS2 http://www.ncbi.nlm.nih.gov/gene/92935 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004867 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA MLL2 http://www.ncbi.nlm.nih.gov/gene/8085 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004868 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA NDNL2 http://www.ncbi.nlm.nih.gov/gene/56160 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004869 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA NDUFA7 http://www.ncbi.nlm.nih.gov/gene/4701 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004870 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA NSD1 http://www.ncbi.nlm.nih.gov/gene/64324 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004871 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA OGDH http://www.ncbi.nlm.nih.gov/gene/4967 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004872 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA PANK3 http://www.ncbi.nlm.nih.gov/gene/79646 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004873 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA POLR2B http://www.ncbi.nlm.nih.gov/gene/5431 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004874 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA PPTC7 http://www.ncbi.nlm.nih.gov/gene/160760 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004875 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA PSMD11 http://www.ncbi.nlm.nih.gov/gene/5717 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004876 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA RAB11FIP1 http://www.ncbi.nlm.nih.gov/gene/80223 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004877 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA RAB11FIP2 http://www.ncbi.nlm.nih.gov/gene/22841 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004878 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA RCOR1 http://www.ncbi.nlm.nih.gov/gene/23186 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004879 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA RNF34 http://www.ncbi.nlm.nih.gov/gene/80196 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004880 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA RPL36A http://www.ncbi.nlm.nih.gov/gene/284230 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004881 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA STARD4 http://www.ncbi.nlm.nih.gov/gene/134429 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004882 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA STOM http://www.ncbi.nlm.nih.gov/gene/2040 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004883 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA TECPR1 http://www.ncbi.nlm.nih.gov/gene/25851 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004884 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA TUBGCP3 http://www.ncbi.nlm.nih.gov/gene/10426 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004885 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA UBR7 http://www.ncbi.nlm.nih.gov/gene/55148 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004886 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA UHMK1 http://www.ncbi.nlm.nih.gov/gene/127933 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004887 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA VKORC1L1 http://www.ncbi.nlm.nih.gov/gene/154807 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004888 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA XIAP http://www.ncbi.nlm.nih.gov/gene/331 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004889 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA ZBTB34 http://www.ncbi.nlm.nih.gov/gene/403341 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004890 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA ZNF160 http://www.ncbi.nlm.nih.gov/gene/90338 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004891 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA ZNF268 http://www.ncbi.nlm.nih.gov/gene/10795 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004892 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA ZNF292 http://www.ncbi.nlm.nih.gov/gene/23036 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004893 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA ZNF526 http://www.ncbi.nlm.nih.gov/gene/116115 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00004894 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART4(ebv-mir-bart4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003726 Lymphoblastoid cell lines - Host mRNA ZNF770 http://www.ncbi.nlm.nih.gov/gene/54989 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00004895 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 nasopharyngeal carcinoma cells - Host mRNA BBC3( PUMA) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074184/pdf/nihms266221.pdf - - 19158788 Depletion of miR-BART5 in EBV-infected nasopharyngeal carcinoma cells was found to trigger elevated levels of apoptosis mediated by PUMA, thus suggesting that miR-BART5 may act to shield EBV-infected epithelial cells, as well as EBV-transformed cells, from apoptotic elimination. VHID00004896 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(BART-5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 - - Host Protein BBC3 http://www.ncbi.nlm.nih.gov/gene/27113 Downregulation PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets (Table 1).Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV- and EBV-encoded miRNAs. VHID00004897 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA SEPT2 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004898 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ACTL6A http://www.ncbi.nlm.nih.gov/gene/86 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004899 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ADO http://www.ncbi.nlm.nih.gov/gene/84890 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004900 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA AFF1 http://www.ncbi.nlm.nih.gov/gene/4299 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004901 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA AGFG1 http://www.ncbi.nlm.nih.gov/gene/3267 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004902 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA AGPAT1 http://www.ncbi.nlm.nih.gov/gene/10554 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004903 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ALKBH4 http://www.ncbi.nlm.nih.gov/gene/54784 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004904 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ANKRD17 http://www.ncbi.nlm.nih.gov/gene/26057 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004905 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ANLN http://www.ncbi.nlm.nih.gov/gene/54443 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004906 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA AP4E1 http://www.ncbi.nlm.nih.gov/gene/23431 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004907 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ARF3 http://www.ncbi.nlm.nih.gov/gene/377 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004908 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ARHGAP5 http://www.ncbi.nlm.nih.gov/gene/394 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004909 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ARID4B http://www.ncbi.nlm.nih.gov/gene/51742 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004910 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ARL15 http://www.ncbi.nlm.nih.gov/gene/54622 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004911 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ARMC8 http://www.ncbi.nlm.nih.gov/gene/25852 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004912 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ATM http://www.ncbi.nlm.nih.gov/gene/472 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004913 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA BAG2 http://www.ncbi.nlm.nih.gov/gene/9532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004914 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA BBX http://www.ncbi.nlm.nih.gov/gene/56987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004915 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA BLOC1S2 http://www.ncbi.nlm.nih.gov/gene/282991 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004916 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA BRWD1 http://www.ncbi.nlm.nih.gov/gene/54014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004917 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA BTBD1 http://www.ncbi.nlm.nih.gov/gene/53339 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004918 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA BTF3L4 http://www.ncbi.nlm.nih.gov/gene/91408 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004919 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA BTG2 http://www.ncbi.nlm.nih.gov/gene/7832 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004920 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA C17orf80 http://www.ncbi.nlm.nih.gov/gene/55028 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004921 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA C1orf21 http://www.ncbi.nlm.nih.gov/gene/81563 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004922 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA C2orf37 http://www.ncbi.nlm.nih.gov/gene/80067 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004923 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA C5orf51 http://www.ncbi.nlm.nih.gov/gene/285636 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004924 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA C8orf84 http://www.ncbi.nlm.nih.gov/gene/157869 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004925 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA CA13 http://www.ncbi.nlm.nih.gov/gene/377677 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004926 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA CABC1 http://www.ncbi.nlm.nih.gov/gene/56997 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004927 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA CAD http://www.ncbi.nlm.nih.gov/gene/790 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004928 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA CAMK2G http://www.ncbi.nlm.nih.gov/gene/818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004929 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA CARD8 http://www.ncbi.nlm.nih.gov/gene/22900 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004930 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA CASP7 http://www.ncbi.nlm.nih.gov/gene/840 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004931 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA CBX5 http://www.ncbi.nlm.nih.gov/gene/23468 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004932 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA CCDC117 http://www.ncbi.nlm.nih.gov/gene/150275 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004933 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA CCND2 http://www.ncbi.nlm.nih.gov/gene/894 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004934 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA CCNL1 http://www.ncbi.nlm.nih.gov/gene/57018 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004935 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA CERK http://www.ncbi.nlm.nih.gov/gene/64781 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004936 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA CHD5 http://www.ncbi.nlm.nih.gov/gene/26038 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004937 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA COQ10B http://www.ncbi.nlm.nih.gov/gene/80219 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004938 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA CPSF7 http://www.ncbi.nlm.nih.gov/gene/79869 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004939 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA CREBL2 http://www.ncbi.nlm.nih.gov/gene/1389 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004940 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA CTNNA1 http://www.ncbi.nlm.nih.gov/gene/1495 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004941 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA CUGBP1 http://www.ncbi.nlm.nih.gov/gene/10658 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004942 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA CYorf15B http://www.ncbi.nlm.nih.gov/gene/84663 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004943 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA DCLRE1C http://www.ncbi.nlm.nih.gov/gene/64421 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004944 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA DCP1A http://www.ncbi.nlm.nih.gov/gene/55802 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004945 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA DISC1 http://www.ncbi.nlm.nih.gov/gene/27185 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004946 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA DOM3Z http://www.ncbi.nlm.nih.gov/gene/1797 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004947 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA DVL3 http://www.ncbi.nlm.nih.gov/gene/1857 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004948 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ELAVL1 http://www.ncbi.nlm.nih.gov/gene/1994 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004949 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ELK4 http://www.ncbi.nlm.nih.gov/gene/2005 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004950 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ELMO2 http://www.ncbi.nlm.nih.gov/gene/63916 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004951 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA EP400 http://www.ncbi.nlm.nih.gov/gene/57634 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004952 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ERI1 http://www.ncbi.nlm.nih.gov/gene/90459 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004953 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ERO1L http://www.ncbi.nlm.nih.gov/gene/30001 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004954 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ESCO2 http://www.ncbi.nlm.nih.gov/gene/157570 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004955 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA FAF2 http://www.ncbi.nlm.nih.gov/gene/23197 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004956 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA FAM120C http://www.ncbi.nlm.nih.gov/gene/54954 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004957 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA FAM160B1 http://www.ncbi.nlm.nih.gov/gene/57700 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004958 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA FAM82B http://www.ncbi.nlm.nih.gov/gene/51115 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004959 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA FBXL3 http://www.ncbi.nlm.nih.gov/gene/26224 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004960 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA FBXO28 http://www.ncbi.nlm.nih.gov/gene/23219 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004961 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA FNDC3A http://www.ncbi.nlm.nih.gov/gene/22862 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004962 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA FUSIP1 http://www.ncbi.nlm.nih.gov/gene/10772 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004963 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA GDI2 http://www.ncbi.nlm.nih.gov/gene/2665 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004964 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA GFOD1 http://www.ncbi.nlm.nih.gov/gene/54438 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004965 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA GIGYF1 http://www.ncbi.nlm.nih.gov/gene/64599 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004966 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA GIT2 http://www.ncbi.nlm.nih.gov/gene/9815 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004967 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA GLT8D3 http://www.ncbi.nlm.nih.gov/gene/283464 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004968 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA GNAI2 http://www.ncbi.nlm.nih.gov/gene/2771 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004969 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA GTF2A2 http://www.ncbi.nlm.nih.gov/gene/2958 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004970 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA HDX http://www.ncbi.nlm.nih.gov/gene/139324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004971 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA HMGCS1 http://www.ncbi.nlm.nih.gov/gene/3157 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004972 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA HNRNPAB http://www.ncbi.nlm.nih.gov/gene/3182 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004973 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA HNRPLL http://www.ncbi.nlm.nih.gov/gene/92906 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004974 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA HSPA4 http://www.ncbi.nlm.nih.gov/gene/3308 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004975 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA HUS1 http://www.ncbi.nlm.nih.gov/gene/3364 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004976 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA IFIH1 http://www.ncbi.nlm.nih.gov/gene/64135 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004977 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA IGF1R http://www.ncbi.nlm.nih.gov/gene/3480 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004978 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA INO80D http://www.ncbi.nlm.nih.gov/gene/54891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004979 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA IRF2 http://www.ncbi.nlm.nih.gov/gene/3660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004980 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA JMY http://www.ncbi.nlm.nih.gov/gene/133746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004981 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA KCNJ2 http://www.ncbi.nlm.nih.gov/gene/3759 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004982 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA KDM2A http://www.ncbi.nlm.nih.gov/gene/22992 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004983 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA KIAA0895 http://www.ncbi.nlm.nih.gov/gene/23366 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004984 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA KIAA1012 http://www.ncbi.nlm.nih.gov/gene/22878 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004985 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA KIAA1211 http://www.ncbi.nlm.nih.gov/gene/57482 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004986 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA KLHDC5 http://www.ncbi.nlm.nih.gov/gene/57542 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004987 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA KLHL23 http://www.ncbi.nlm.nih.gov/gene/151230 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004988 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA KPNA4 http://www.ncbi.nlm.nih.gov/gene/3840 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004989 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA KPNA6 http://www.ncbi.nlm.nih.gov/gene/23633 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004990 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA LGALS1 http://www.ncbi.nlm.nih.gov/gene/3956 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004991 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA LRRC58 http://www.ncbi.nlm.nih.gov/gene/116064 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004992 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA M6PR http://www.ncbi.nlm.nih.gov/gene/4074 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004993 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA MAGED2 http://www.ncbi.nlm.nih.gov/gene/10916 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004994 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA MAP3K1 http://www.ncbi.nlm.nih.gov/gene/4214 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004995 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA MAP3K2 http://www.ncbi.nlm.nih.gov/gene/10746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004996 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA MAP7D1 http://www.ncbi.nlm.nih.gov/gene/55700 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004997 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA MAPK1 http://www.ncbi.nlm.nih.gov/gene/5594 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004998 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA MBNL2 http://www.ncbi.nlm.nih.gov/gene/10150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00004999 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA MEF2A http://www.ncbi.nlm.nih.gov/gene/4205 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005000 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA MFAP3 http://www.ncbi.nlm.nih.gov/gene/4238 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005001 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA MGA http://www.ncbi.nlm.nih.gov/gene/23269 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005002 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA MIA3 http://www.ncbi.nlm.nih.gov/gene/375056 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005003 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA MLEC http://www.ncbi.nlm.nih.gov/gene/9761 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005004 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA MLL5 http://www.ncbi.nlm.nih.gov/gene/55904 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005005 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA MOBKL1A http://www.ncbi.nlm.nih.gov/gene/92597 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005006 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA MOBKL3 http://www.ncbi.nlm.nih.gov/gene/25843 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005007 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA MTPN http://www.ncbi.nlm.nih.gov/gene/767558 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005008 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA NCOA2 http://www.ncbi.nlm.nih.gov/gene/10499 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005009 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA NOL12 http://www.ncbi.nlm.nih.gov/gene/79159 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005010 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA NP http://www.ncbi.nlm.nih.gov/gene/4860 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005011 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA NUCKS1 http://www.ncbi.nlm.nih.gov/gene/64710 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005012 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA NUP160 http://www.ncbi.nlm.nih.gov/gene/23279 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005013 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ORMDL3 http://www.ncbi.nlm.nih.gov/gene/94103 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005014 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA OSBPL11 http://www.ncbi.nlm.nih.gov/gene/114885 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005015 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA PAFAH1B1 http://www.ncbi.nlm.nih.gov/gene/5048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005016 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA PARD6B http://www.ncbi.nlm.nih.gov/gene/84612 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005017 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA PDE4D http://www.ncbi.nlm.nih.gov/gene/5144 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005018 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA PEX19 http://www.ncbi.nlm.nih.gov/gene/5824 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005019 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA PHC3 http://www.ncbi.nlm.nih.gov/gene/80012 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005020 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA PHF20L1 http://www.ncbi.nlm.nih.gov/gene/51105 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005021 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA PHF8 http://www.ncbi.nlm.nih.gov/gene/23133 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005022 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA PIK3C2A http://www.ncbi.nlm.nih.gov/gene/5286 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005023 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA PM20D2 http://www.ncbi.nlm.nih.gov/gene/135293 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005024 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA POLI http://www.ncbi.nlm.nih.gov/gene/11201 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005025 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA PRKAR2A http://www.ncbi.nlm.nih.gov/gene/5576 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005026 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA PTBP2 http://www.ncbi.nlm.nih.gov/gene/58155 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005027 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA PTEN http://www.ncbi.nlm.nih.gov/gene/11191 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005028 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA PXMP3 http://www.ncbi.nlm.nih.gov/gene/5828 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005029 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA PXT1 http://www.ncbi.nlm.nih.gov/gene/222659 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005030 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA RAB5A http://www.ncbi.nlm.nih.gov/gene/5868 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005031 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA RAF1 http://www.ncbi.nlm.nih.gov/gene/5894 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005032 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA RBM16 http://www.ncbi.nlm.nih.gov/gene/22828 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005033 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA RC3H2 http://www.ncbi.nlm.nih.gov/gene/54542 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005034 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA REV1 http://www.ncbi.nlm.nih.gov/gene/51455 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005035 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA REV3L http://www.ncbi.nlm.nih.gov/gene/5980 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005036 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA RGP1 http://www.ncbi.nlm.nih.gov/gene/9827 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005037 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA RHOQ http://www.ncbi.nlm.nih.gov/gene/730041 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005038 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA RNF181 http://www.ncbi.nlm.nih.gov/gene/51255 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005039 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA RNF38 http://www.ncbi.nlm.nih.gov/gene/152006 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005040 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA RORA http://www.ncbi.nlm.nih.gov/gene/6095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005041 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA RREB1 http://www.ncbi.nlm.nih.gov/gene/6239 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005042 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA RRN3 http://www.ncbi.nlm.nih.gov/gene/54700 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005043 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA SAPS3 http://www.ncbi.nlm.nih.gov/gene/55291 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005044 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA SECISBP2L http://www.ncbi.nlm.nih.gov/gene/9728 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005045 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA SETD2 http://www.ncbi.nlm.nih.gov/gene/29072 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005046 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA SETD5 http://www.ncbi.nlm.nih.gov/gene/55209 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005047 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA SFRS18 http://www.ncbi.nlm.nih.gov/gene/25957 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005048 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA SH3BP2 http://www.ncbi.nlm.nih.gov/gene/6452 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005049 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA SHC1 http://www.ncbi.nlm.nih.gov/gene/6464 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005050 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA SKP1 http://www.ncbi.nlm.nih.gov/gene/6500 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005051 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA SLC41A1 http://www.ncbi.nlm.nih.gov/gene/254428 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005052 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA SMAD3 http://www.ncbi.nlm.nih.gov/gene/4088 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005053 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA SMG7 http://www.ncbi.nlm.nih.gov/gene/9887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005054 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA SON http://www.ncbi.nlm.nih.gov/gene/6651 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005055 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA SOX12 http://www.ncbi.nlm.nih.gov/gene/6666 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005056 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA STARD7 http://www.ncbi.nlm.nih.gov/gene/56910 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005057 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA STAT6 http://www.ncbi.nlm.nih.gov/gene/6778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005058 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA SUMO1 http://www.ncbi.nlm.nih.gov/gene/7341 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005059 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA TBL1XR1 http://www.ncbi.nlm.nih.gov/gene/79718 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005060 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA TMBIM1 http://www.ncbi.nlm.nih.gov/gene/64114 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005061 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA TNKS2 http://www.ncbi.nlm.nih.gov/gene/80351 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005062 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA TPRG1L http://www.ncbi.nlm.nih.gov/gene/127262 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005063 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA TRAM2 http://www.ncbi.nlm.nih.gov/gene/9697 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005064 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA TSPYL1 http://www.ncbi.nlm.nih.gov/gene/7259 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005065 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA UBE2A http://www.ncbi.nlm.nih.gov/gene/7319 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005066 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA UBL5 http://www.ncbi.nlm.nih.gov/gene/59286 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005067 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA UBQLN1 http://www.ncbi.nlm.nih.gov/gene/29979 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005068 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA UBXN7 http://www.ncbi.nlm.nih.gov/gene/26043 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005069 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA USP37 http://www.ncbi.nlm.nih.gov/gene/57695 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005070 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA VMA21 http://www.ncbi.nlm.nih.gov/gene/203547 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005071 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA VPS13A http://www.ncbi.nlm.nih.gov/gene/23230 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005072 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA XIAP http://www.ncbi.nlm.nih.gov/gene/331 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005073 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA XPNPEP1 http://www.ncbi.nlm.nih.gov/gene/7511 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005074 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA XRN1 http://www.ncbi.nlm.nih.gov/gene/54464 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005075 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA YPEL2 http://www.ncbi.nlm.nih.gov/gene/388403 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005076 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ZBTB47 http://www.ncbi.nlm.nih.gov/gene/92999 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005077 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ZC3HAV1 http://www.ncbi.nlm.nih.gov/gene/56829 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005078 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ZCCHC3 http://www.ncbi.nlm.nih.gov/gene/85364 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005079 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ZMYM6 http://www.ncbi.nlm.nih.gov/gene/100130633 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005080 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ZNF12 http://www.ncbi.nlm.nih.gov/gene/7559 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005081 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ZNF160 http://www.ncbi.nlm.nih.gov/gene/90338 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005082 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ZNF264 http://www.ncbi.nlm.nih.gov/gene/9422 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005083 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ZNF28 http://www.ncbi.nlm.nih.gov/gene/7576 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005084 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ZNF295 http://www.ncbi.nlm.nih.gov/gene/49854 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005085 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ZNF33A http://www.ncbi.nlm.nih.gov/gene/7581 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005086 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ZNF367 http://www.ncbi.nlm.nih.gov/gene/195828 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005087 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ZNF451 http://www.ncbi.nlm.nih.gov/gene/26036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005088 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ZNF566 http://www.ncbi.nlm.nih.gov/gene/84924 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005089 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ZNF618 http://www.ncbi.nlm.nih.gov/gene/114991 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005090 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ZNF805 http://www.ncbi.nlm.nih.gov/gene/390980 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005091 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(ebv-mir-bart5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 BC-1 - Host mRNA ZRANB1 http://www.ncbi.nlm.nih.gov/gene/54764 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005092 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(miR-BART5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 - - Host Protein BBC3 http://www.ncbi.nlm.nih.gov/gene/27113 - Report arrays. 22100165 We detected the reported cluster, containing a seed match to miRBART16. We also detected an additional cluster with a seed match to miR-BART6-3p. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00005093 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(miR-BART5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 - - Host Protein PUMA http://www.ncbi.nlm.nih.gov/gene/27113 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00005094 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(miR-BART5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 - - Host mRNA BBC3(PUMA) http://www.ncbi.nlm.nih.gov/gene/27113 - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VHID00005095 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(miR-BART5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 293T cells - Host Protein NFKB1 http://www.ncbi.nlm.nih.gov/gene/4790 Downregulation luciferase reporter assays, photoactivatable cross-linking and immunoprecipitation(PAR-CLIP), and deep sequencing and qRT-PCR. 24257599 These data demonstrate that miR-rL1-8 can functionally substitute for miRBART5 and that miR-BART5 and miR-BART16 negatively regulate NFKB signaling by directly targeting the LMP1 3'UTR. VHID00005096 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(miR-BART5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 B cells - Host Protein PUMA http://www.ncbi.nlm.nih.gov/gene/27113 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 EBV miR-BART5 inhibits the expression of the cellular protein PUMA(p53 upregulated modulator of apoptosis) to promote host cell survival and the establishment of latent EBV in-fection. VHID00005097 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(miR-BART5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 Nasopharyngeal carcinoma(NPC) and EBV-GC cells - Host Protein BBC3(PUMA) http://www.ncbi.nlm.nih.gov/gene/27113 Downregulation Reporter assay,Plasmid construction, Cell culture, transfection, Target prediction, RNA analysis, Western blotting, Apoptosis assays. 18838543 We report on the regulation of a cellular protein named p53 up-regulated modulator of apoptosis (PUMA) by an EBV miRNA known as miR-BART5, which is abundantly expressed in NPC and EBV-GC cells. VHID00005098 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(mir-BART5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 B cell lymphomagenesis - Host mRNA PUMA http://www.ncbi.nlm.nih.gov/gene/27113 Upregulation Western Blotting, Northern Blotting, Luciferase Reporter Assay. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VHID00005099 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART6(miR-BART6) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003728 - - Host Protein DICER http://www.ncbi.nlm.nih.gov/gene/23405 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00005100 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART6(miR-BART6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003414 Nasopharyngeal epithelial tissues - Host mRNA DICER1(Dicer1) http://www.ncbi.nlm.nih.gov/gene/23405 Downregulation Luciferase assay. 23097559 It was previously reported that miR-BART6-5p RNAs encoded by EBV genome silence Dicer1 through multiple target sites located in the 3' UTR of Dicer1 mRNA. VHID00005101 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART6(mir-BART6) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003728 B cell lymphomagenesis - Host mRNA DICER1 http://www.ncbi.nlm.nih.gov/gene/23405 Upregulation Western Blotting, Northern Blotting, Luciferase Reporter Assay. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VHID00005102 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA SEPT7 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005103 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ABTB2 http://www.ncbi.nlm.nih.gov/gene/25841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005104 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ANKFY1 http://www.ncbi.nlm.nih.gov/gene/51479 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005105 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ANKRD46 http://www.ncbi.nlm.nih.gov/gene/157567 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005106 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ANXA2 http://www.ncbi.nlm.nih.gov/gene/305 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005107 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA AP1S3 http://www.ncbi.nlm.nih.gov/gene/130340 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005108 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA APLP2 http://www.ncbi.nlm.nih.gov/gene/334 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005109 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA APPL1 http://www.ncbi.nlm.nih.gov/gene/26060 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005110 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ARID1B http://www.ncbi.nlm.nih.gov/gene/57492 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005111 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ASB1 http://www.ncbi.nlm.nih.gov/gene/51665 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005112 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ATF7 http://www.ncbi.nlm.nih.gov/gene/11016 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005113 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ATG3 http://www.ncbi.nlm.nih.gov/gene/64422 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005114 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA BACH1 http://www.ncbi.nlm.nih.gov/gene/571 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005115 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA BAZ1B http://www.ncbi.nlm.nih.gov/gene/9031 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005116 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA BRWD2 http://www.ncbi.nlm.nih.gov/gene/55717 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005117 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA C10orf18 http://www.ncbi.nlm.nih.gov/gene/54906 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005118 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA C12orf5 http://www.ncbi.nlm.nih.gov/gene/57103 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005119 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA C1orf55 http://www.ncbi.nlm.nih.gov/gene/163859 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005120 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA C20orf177 http://www.ncbi.nlm.nih.gov/gene/63939 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005121 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA C2orf60 http://www.ncbi.nlm.nih.gov/gene/129450 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005122 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA C4orf16 http://www.ncbi.nlm.nih.gov/gene/55435 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005123 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA C4orf46 http://www.ncbi.nlm.nih.gov/gene/201725 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005124 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA C7orf60 http://www.ncbi.nlm.nih.gov/gene/154743 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005125 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA C9orf41 http://www.ncbi.nlm.nih.gov/gene/138199 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005126 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA CA13 http://www.ncbi.nlm.nih.gov/gene/377677 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005127 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA CAMSAP1L1 http://www.ncbi.nlm.nih.gov/gene/23271 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005128 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA CASP3 http://www.ncbi.nlm.nih.gov/gene/836 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005129 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA CAV1 http://www.ncbi.nlm.nih.gov/gene/857 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005130 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005131 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA CD200R1 http://www.ncbi.nlm.nih.gov/gene/131450 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005132 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA CENPQ http://www.ncbi.nlm.nih.gov/gene/55166 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005133 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA CHKA http://www.ncbi.nlm.nih.gov/gene/1119 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005134 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA CHUK http://www.ncbi.nlm.nih.gov/gene/1147 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005135 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA CLCC1 http://www.ncbi.nlm.nih.gov/gene/23155 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005136 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA CLCN3 http://www.ncbi.nlm.nih.gov/gene/1182 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005137 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA CPNE3 http://www.ncbi.nlm.nih.gov/gene/8895 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005138 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA CSDE1 http://www.ncbi.nlm.nih.gov/gene/7812 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005139 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA CTDSPL2 http://www.ncbi.nlm.nih.gov/gene/51496 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005140 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA CTSL2 http://www.ncbi.nlm.nih.gov/gene/1515 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005141 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA DCP1A http://www.ncbi.nlm.nih.gov/gene/55802 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005142 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA DCTN4 http://www.ncbi.nlm.nih.gov/gene/51164 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005143 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA DDHD2 http://www.ncbi.nlm.nih.gov/gene/23259 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005144 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA DERL1 http://www.ncbi.nlm.nih.gov/gene/79139 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005145 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA DHX33 http://www.ncbi.nlm.nih.gov/gene/56919 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005146 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA DOCK4 http://www.ncbi.nlm.nih.gov/gene/9732 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005147 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA DYRK1A http://www.ncbi.nlm.nih.gov/gene/1859 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005148 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA EIF2AK2 http://www.ncbi.nlm.nih.gov/gene/5610 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005149 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ELK4 http://www.ncbi.nlm.nih.gov/gene/2005 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005150 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ERI1 http://www.ncbi.nlm.nih.gov/gene/90459 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005151 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA FAM105B http://www.ncbi.nlm.nih.gov/gene/90268 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005152 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA FAM119A http://www.ncbi.nlm.nih.gov/gene/151194 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005153 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA FAM160B1 http://www.ncbi.nlm.nih.gov/gene/57700 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005154 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA FAM33A http://www.ncbi.nlm.nih.gov/gene/348235 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005155 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA FBXO22 http://www.ncbi.nlm.nih.gov/gene/26263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005156 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA FCF1 http://www.ncbi.nlm.nih.gov/gene/51077 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005157 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA FGD6 http://www.ncbi.nlm.nih.gov/gene/55785 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005158 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA FLOT1 http://www.ncbi.nlm.nih.gov/gene/10211 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005159 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA FOXP1 http://www.ncbi.nlm.nih.gov/gene/27086 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005160 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA FOXP2 http://www.ncbi.nlm.nih.gov/gene/93986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005161 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA FYTTD1 http://www.ncbi.nlm.nih.gov/gene/84248 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005162 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA G2E3 http://www.ncbi.nlm.nih.gov/gene/55632 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005163 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA GAB1 http://www.ncbi.nlm.nih.gov/gene/2549 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005164 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA GARS http://www.ncbi.nlm.nih.gov/gene/2617 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005165 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA GBF1 http://www.ncbi.nlm.nih.gov/gene/8729 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005166 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA GCET2 http://www.ncbi.nlm.nih.gov/gene/257144 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005167 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA GLO1 http://www.ncbi.nlm.nih.gov/gene/2739 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005168 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA GMNN http://www.ncbi.nlm.nih.gov/gene/51053 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005169 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA GTPBP10 http://www.ncbi.nlm.nih.gov/gene/85865 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005170 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA HINT3 http://www.ncbi.nlm.nih.gov/gene/135114 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005171 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA HNRNPF http://www.ncbi.nlm.nih.gov/gene/3185 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005172 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA HNRNPR http://www.ncbi.nlm.nih.gov/gene/10236 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005173 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA HNRNPU http://www.ncbi.nlm.nih.gov/gene/3192 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005174 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA HOXA1 http://www.ncbi.nlm.nih.gov/gene/3198 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005175 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA HPS3 http://www.ncbi.nlm.nih.gov/gene/84343 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005176 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA IARS2 http://www.ncbi.nlm.nih.gov/gene/55699 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005177 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA IGDCC4 http://www.ncbi.nlm.nih.gov/gene/57722 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005178 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ING3 http://www.ncbi.nlm.nih.gov/gene/54556 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005179 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA INPP4A http://www.ncbi.nlm.nih.gov/gene/3631 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005180 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA JHDM1D http://www.ncbi.nlm.nih.gov/gene/80853 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005181 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA KAT2B http://www.ncbi.nlm.nih.gov/gene/8850 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005182 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA KIAA0232 http://www.ncbi.nlm.nih.gov/gene/9778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005183 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA KIAA0494 http://www.ncbi.nlm.nih.gov/gene/9813 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005184 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA KLHL36 http://www.ncbi.nlm.nih.gov/gene/79786 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005185 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA LPHN3 http://www.ncbi.nlm.nih.gov/gene/23284 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005186 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA LRRC58 http://www.ncbi.nlm.nih.gov/gene/116064 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005187 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA LRRC8B http://www.ncbi.nlm.nih.gov/gene/23507 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005188 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA MAML1 http://www.ncbi.nlm.nih.gov/gene/9794 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005189 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA MAPK1 http://www.ncbi.nlm.nih.gov/gene/5594 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005190 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA MBNL2 http://www.ncbi.nlm.nih.gov/gene/10150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005191 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA MCM2 http://www.ncbi.nlm.nih.gov/gene/4171 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005192 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA MEX3C http://www.ncbi.nlm.nih.gov/gene/51320 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005193 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA MOBKL1A http://www.ncbi.nlm.nih.gov/gene/92597 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005194 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA MTMR12 http://www.ncbi.nlm.nih.gov/gene/54545 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005195 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA MYPOP http://www.ncbi.nlm.nih.gov/gene/339344 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005196 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA NCOA2 http://www.ncbi.nlm.nih.gov/gene/10499 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005197 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA NDUFS3 http://www.ncbi.nlm.nih.gov/gene/4722 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005198 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA NEDD1 http://www.ncbi.nlm.nih.gov/gene/121441 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005199 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA NEK7 http://www.ncbi.nlm.nih.gov/gene/140609 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005200 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA NIP7 http://www.ncbi.nlm.nih.gov/gene/51388 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005201 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA NOTCH2 http://www.ncbi.nlm.nih.gov/gene/4853 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005202 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA NUDT15 http://www.ncbi.nlm.nih.gov/gene/55270 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005203 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA NUPL1 http://www.ncbi.nlm.nih.gov/gene/9818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005204 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA PAK2 http://www.ncbi.nlm.nih.gov/gene/5062 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005205 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA PATZ1 http://www.ncbi.nlm.nih.gov/gene/23598 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005206 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA PDZD8 http://www.ncbi.nlm.nih.gov/gene/118987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005207 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA PECR http://www.ncbi.nlm.nih.gov/gene/55825 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005208 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA PIK3CB http://www.ncbi.nlm.nih.gov/gene/5291 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005209 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA PLAGL1 http://www.ncbi.nlm.nih.gov/gene/5325 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005210 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA PLCL1 http://www.ncbi.nlm.nih.gov/gene/5334 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005211 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA POLR1B http://www.ncbi.nlm.nih.gov/gene/84172 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005212 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA POU2F2 http://www.ncbi.nlm.nih.gov/gene/5452 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005213 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA PPAP2B http://www.ncbi.nlm.nih.gov/gene/8613 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005214 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA PPP1R1C http://www.ncbi.nlm.nih.gov/gene/151242 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005215 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA PPP2R5A http://www.ncbi.nlm.nih.gov/gene/5525 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005216 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA PPP3CB http://www.ncbi.nlm.nih.gov/gene/5532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005217 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA PPP6C http://www.ncbi.nlm.nih.gov/gene/5537 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005218 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA PPTC7 http://www.ncbi.nlm.nih.gov/gene/160760 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005219 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA PRKAB2 http://www.ncbi.nlm.nih.gov/gene/5565 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005220 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA PRKACB http://www.ncbi.nlm.nih.gov/gene/5567 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005221 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA PTPN13 http://www.ncbi.nlm.nih.gov/gene/5783 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005222 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA PTPRC http://www.ncbi.nlm.nih.gov/gene/5788 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005223 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA RAB22A http://www.ncbi.nlm.nih.gov/gene/57403 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005224 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA RASGRP3 http://www.ncbi.nlm.nih.gov/gene/25780 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005225 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA RCSD1 http://www.ncbi.nlm.nih.gov/gene/92241 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005226 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA REST http://www.ncbi.nlm.nih.gov/gene/5978 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005227 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA RHOA http://www.ncbi.nlm.nih.gov/gene/387 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005228 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA RNF125 http://www.ncbi.nlm.nih.gov/gene/54941 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005229 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA RNF141 http://www.ncbi.nlm.nih.gov/gene/50862 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005230 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA RNF19A http://www.ncbi.nlm.nih.gov/gene/25897 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005231 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA RORA http://www.ncbi.nlm.nih.gov/gene/6095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005232 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA RPL5 http://www.ncbi.nlm.nih.gov/gene/647436 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005233 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA SCFD1 http://www.ncbi.nlm.nih.gov/gene/23256 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005234 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA SDCCAG1 http://www.ncbi.nlm.nih.gov/gene/9147 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005235 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA SERAC1 http://www.ncbi.nlm.nih.gov/gene/84947 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005236 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA SERINC3 http://www.ncbi.nlm.nih.gov/gene/10955 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005237 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA SETD7 http://www.ncbi.nlm.nih.gov/gene/80854 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005238 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA SFMBT2 http://www.ncbi.nlm.nih.gov/gene/57713 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005239 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA SFPQ http://www.ncbi.nlm.nih.gov/gene/6421 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005240 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA SHOC2 http://www.ncbi.nlm.nih.gov/gene/8036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005241 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA SKIV2L http://www.ncbi.nlm.nih.gov/gene/6499 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005242 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA SLAIN2 http://www.ncbi.nlm.nih.gov/gene/57606 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005243 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA SLC16A4 http://www.ncbi.nlm.nih.gov/gene/9122 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005244 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA SLC35F2 http://www.ncbi.nlm.nih.gov/gene/54733 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005245 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA SLC38A2 http://www.ncbi.nlm.nih.gov/gene/54407 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005246 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA SMG7 http://www.ncbi.nlm.nih.gov/gene/9887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005247 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA SNX18 http://www.ncbi.nlm.nih.gov/gene/112574 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005248 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA SNX27 http://www.ncbi.nlm.nih.gov/gene/81609 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005249 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA SOCS6 http://www.ncbi.nlm.nih.gov/gene/9306 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005250 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA SRP72 http://www.ncbi.nlm.nih.gov/gene/6731 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005251 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA STK38L http://www.ncbi.nlm.nih.gov/gene/23012 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005252 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA STYX http://www.ncbi.nlm.nih.gov/gene/6815 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005253 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA SYNJ1 http://www.ncbi.nlm.nih.gov/gene/8867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005254 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA TAF2 http://www.ncbi.nlm.nih.gov/gene/6873 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005255 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA TAOK1 http://www.ncbi.nlm.nih.gov/gene/57551 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005256 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA TBL1XR1 http://www.ncbi.nlm.nih.gov/gene/79718 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005257 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA TET2 http://www.ncbi.nlm.nih.gov/gene/54790 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005258 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA TET3 http://www.ncbi.nlm.nih.gov/gene/200424 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005259 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA TFAM http://www.ncbi.nlm.nih.gov/gene/7019 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005260 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA THAP1 http://www.ncbi.nlm.nih.gov/gene/55145 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005261 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA THOC7 http://www.ncbi.nlm.nih.gov/gene/80145 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005262 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA TIFA http://www.ncbi.nlm.nih.gov/gene/92610 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005263 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA TLK1 http://www.ncbi.nlm.nih.gov/gene/9874 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005264 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA TM7SF3 http://www.ncbi.nlm.nih.gov/gene/51768 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005265 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA TMCC1 http://www.ncbi.nlm.nih.gov/gene/23023 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005266 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA TMEM19 http://www.ncbi.nlm.nih.gov/gene/55266 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005267 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA TMEM209 http://www.ncbi.nlm.nih.gov/gene/84928 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005268 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA TMEM55A http://www.ncbi.nlm.nih.gov/gene/55529 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005269 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA TNFRSF10B http://www.ncbi.nlm.nih.gov/gene/8795 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005270 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA UBA6 http://www.ncbi.nlm.nih.gov/gene/55236 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005271 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA UBE2K http://www.ncbi.nlm.nih.gov/gene/3093 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005272 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA UBR7 http://www.ncbi.nlm.nih.gov/gene/55148 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005273 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA UBTD2 http://www.ncbi.nlm.nih.gov/gene/92181 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005274 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA UBXN7 http://www.ncbi.nlm.nih.gov/gene/26043 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005275 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA UHMK1 http://www.ncbi.nlm.nih.gov/gene/127933 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005276 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA USP15 http://www.ncbi.nlm.nih.gov/gene/9958 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005277 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA USP47 http://www.ncbi.nlm.nih.gov/gene/55031 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005278 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA VBP1 http://www.ncbi.nlm.nih.gov/gene/7411 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005279 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA VPS26A http://www.ncbi.nlm.nih.gov/gene/9559 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005280 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA XPO1 http://www.ncbi.nlm.nih.gov/gene/7514 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005281 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA YEATS4 http://www.ncbi.nlm.nih.gov/gene/8089 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005282 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA YWHAG http://www.ncbi.nlm.nih.gov/gene/7532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005283 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ZBTB1 http://www.ncbi.nlm.nih.gov/gene/22890 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005284 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ZCCHC7 http://www.ncbi.nlm.nih.gov/gene/84186 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005285 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ZMAT3 http://www.ncbi.nlm.nih.gov/gene/64393 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005286 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ZNF180 http://www.ncbi.nlm.nih.gov/gene/7733 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005287 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ZNF217 http://www.ncbi.nlm.nih.gov/gene/7764 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005288 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ZNF24 http://www.ncbi.nlm.nih.gov/gene/7572 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005289 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ZNF460 http://www.ncbi.nlm.nih.gov/gene/10794 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005290 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ZNF493 http://www.ncbi.nlm.nih.gov/gene/284443 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005291 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ZNF528 http://www.ncbi.nlm.nih.gov/gene/147658 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005292 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ZNF585B http://www.ncbi.nlm.nih.gov/gene/92285 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005293 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ZNF714 http://www.ncbi.nlm.nih.gov/gene/148206 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005294 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ZNF791 http://www.ncbi.nlm.nih.gov/gene/163049 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005295 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ZNF800 http://www.ncbi.nlm.nih.gov/gene/168850 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005296 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART7(ebv-mir-bart7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003729 BC-1 - Host mRNA ZNF805 http://www.ncbi.nlm.nih.gov/gene/390980 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005297 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA ACTR1A http://www.ncbi.nlm.nih.gov/gene/10121 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005298 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA ARID2 http://www.ncbi.nlm.nih.gov/gene/196528 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005299 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA C13orf23 http://www.ncbi.nlm.nih.gov/gene/80209 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005300 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA C14orf129 http://www.ncbi.nlm.nih.gov/gene/51527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005301 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA CCND2 http://www.ncbi.nlm.nih.gov/gene/894 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005302 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA DENND1B http://www.ncbi.nlm.nih.gov/gene/163486 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005303 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA DOLPP1 http://www.ncbi.nlm.nih.gov/gene/57171 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005304 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA DTX3L http://www.ncbi.nlm.nih.gov/gene/151636 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005305 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA FBXO10 http://www.ncbi.nlm.nih.gov/gene/26267 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005306 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA FTSJ3 http://www.ncbi.nlm.nih.gov/gene/117246 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005307 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA FUBP3 http://www.ncbi.nlm.nih.gov/gene/8939 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005308 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA GNB1 http://www.ncbi.nlm.nih.gov/gene/2782 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005309 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA INPP5E http://www.ncbi.nlm.nih.gov/gene/56623 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005310 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA KIAA0528 http://www.ncbi.nlm.nih.gov/gene/9847 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005311 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA KPNA3 http://www.ncbi.nlm.nih.gov/gene/3839 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005312 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA LARP4 http://www.ncbi.nlm.nih.gov/gene/113251 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005313 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA LIN28B http://www.ncbi.nlm.nih.gov/gene/389421 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005314 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA NCOR1 http://www.ncbi.nlm.nih.gov/gene/9611 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005315 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA NF1 http://www.ncbi.nlm.nih.gov/gene/4763 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005316 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA NFIA http://www.ncbi.nlm.nih.gov/gene/4774 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005317 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA NOS3 http://www.ncbi.nlm.nih.gov/gene/4846 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005318 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA PCTK2 http://www.ncbi.nlm.nih.gov/gene/5128 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005319 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA PHF12 http://www.ncbi.nlm.nih.gov/gene/57649 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005320 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA PKN2 http://www.ncbi.nlm.nih.gov/gene/5586 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005321 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA PSMC3IP http://www.ncbi.nlm.nih.gov/gene/29893 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005322 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA PURB http://www.ncbi.nlm.nih.gov/gene/5814 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005323 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA RALBP1 http://www.ncbi.nlm.nih.gov/gene/10928 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005324 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA RPL15 http://www.ncbi.nlm.nih.gov/gene/6138 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005325 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA RPS6KA3 http://www.ncbi.nlm.nih.gov/gene/6197 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005326 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA RTN4 http://www.ncbi.nlm.nih.gov/gene/57142 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005327 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA RWDD4A http://www.ncbi.nlm.nih.gov/gene/201965 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005328 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA SEC11B http://www.ncbi.nlm.nih.gov/gene/157708 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005329 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA SLC11A2 http://www.ncbi.nlm.nih.gov/gene/4891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005330 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA SLC39A14 http://www.ncbi.nlm.nih.gov/gene/23516 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005331 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA SRGAP2 http://www.ncbi.nlm.nih.gov/gene/23380 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005332 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA SSR3 http://www.ncbi.nlm.nih.gov/gene/6747 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005333 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA STAG1 http://www.ncbi.nlm.nih.gov/gene/10274 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005334 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA STXBP4 http://www.ncbi.nlm.nih.gov/gene/252983 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005335 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA TET2 http://www.ncbi.nlm.nih.gov/gene/54790 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005336 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA TMEM111 http://www.ncbi.nlm.nih.gov/gene/55831 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005337 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA TMEM170A http://www.ncbi.nlm.nih.gov/gene/124491 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005338 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA TMEM2 http://www.ncbi.nlm.nih.gov/gene/23670 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005339 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA TRIB1 http://www.ncbi.nlm.nih.gov/gene/10221 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005340 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA ZBED4 http://www.ncbi.nlm.nih.gov/gene/9889 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005341 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART8(ebv-mir-bart8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003730 BC-1 - Host mRNA ZBTB10 http://www.ncbi.nlm.nih.gov/gene/65986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005342 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA ADRB1 http://www.ncbi.nlm.nih.gov/gene/153 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005343 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA ASH1L http://www.ncbi.nlm.nih.gov/gene/55870 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005344 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA BAK1 http://www.ncbi.nlm.nih.gov/gene/578 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005345 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA BNC2 http://www.ncbi.nlm.nih.gov/gene/54796 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005346 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA BRMS1L http://www.ncbi.nlm.nih.gov/gene/84312 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005347 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA C12orf35 http://www.ncbi.nlm.nih.gov/gene/55196 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005348 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA C19orf42 http://www.ncbi.nlm.nih.gov/gene/79086 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005349 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA C2orf18 http://www.ncbi.nlm.nih.gov/gene/54978 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005350 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA C5orf51 http://www.ncbi.nlm.nih.gov/gene/285636 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005351 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA C7orf70 http://www.ncbi.nlm.nih.gov/gene/84792 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005352 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA CBX1 http://www.ncbi.nlm.nih.gov/gene/10951 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005353 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005354 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA CD86 http://www.ncbi.nlm.nih.gov/gene/942 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005355 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA CDC42 http://www.ncbi.nlm.nih.gov/gene/998 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005356 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA CDK6 http://www.ncbi.nlm.nih.gov/gene/1021 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005357 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA CHPT1 http://www.ncbi.nlm.nih.gov/gene/56994 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005358 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA CLPX http://www.ncbi.nlm.nih.gov/gene/10845 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005359 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA CMPK1 http://www.ncbi.nlm.nih.gov/gene/51727 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005360 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA CMTM6 http://www.ncbi.nlm.nih.gov/gene/54918 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005361 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA CPEB3 http://www.ncbi.nlm.nih.gov/gene/22849 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005362 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA CREBZF http://www.ncbi.nlm.nih.gov/gene/58487 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005363 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA CUX1 http://www.ncbi.nlm.nih.gov/gene/1523 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005364 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA DDI2 http://www.ncbi.nlm.nih.gov/gene/84301 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005365 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA DDX19A http://www.ncbi.nlm.nih.gov/gene/55308 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005366 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA DERL1 http://www.ncbi.nlm.nih.gov/gene/79139 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005367 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA DMTF1 http://www.ncbi.nlm.nih.gov/gene/9988 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005368 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA DYRK1A http://www.ncbi.nlm.nih.gov/gene/1859 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005369 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA EIF3L http://www.ncbi.nlm.nih.gov/gene/51386 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005370 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA EIF5 http://www.ncbi.nlm.nih.gov/gene/1983 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005371 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA EZH1 http://www.ncbi.nlm.nih.gov/gene/2145 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005372 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA FLI1 http://www.ncbi.nlm.nih.gov/gene/2313 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005373 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA FOXO3 http://www.ncbi.nlm.nih.gov/gene/2310 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005374 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA H2AFZ http://www.ncbi.nlm.nih.gov/gene/3015 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005375 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA HNRPDL http://www.ncbi.nlm.nih.gov/gene/9987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005376 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA HS3ST3B1 http://www.ncbi.nlm.nih.gov/gene/9953 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005377 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA KCTD3 http://www.ncbi.nlm.nih.gov/gene/51133 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005378 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA KDELR2 http://www.ncbi.nlm.nih.gov/gene/11014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005379 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA KIAA1211 http://www.ncbi.nlm.nih.gov/gene/57482 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005380 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA KIAA1430 http://www.ncbi.nlm.nih.gov/gene/57587 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005381 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA KIAA2018 http://www.ncbi.nlm.nih.gov/gene/205717 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005382 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA KRCC1 http://www.ncbi.nlm.nih.gov/gene/51315 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005383 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA KRT10 http://www.ncbi.nlm.nih.gov/gene/3858 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005384 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA LARP4 http://www.ncbi.nlm.nih.gov/gene/113251 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005385 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA LENG4 http://www.ncbi.nlm.nih.gov/gene/79143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005386 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA LGR4 http://www.ncbi.nlm.nih.gov/gene/55366 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005387 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA LIMA1 http://www.ncbi.nlm.nih.gov/gene/51474 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005388 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA LZIC http://www.ncbi.nlm.nih.gov/gene/84328 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005389 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA MALT1 http://www.ncbi.nlm.nih.gov/gene/10892 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005390 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA MBNL1 http://www.ncbi.nlm.nih.gov/gene/4154 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005391 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA MCL1 http://www.ncbi.nlm.nih.gov/gene/4170 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005392 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA MORC3 http://www.ncbi.nlm.nih.gov/gene/23515 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005393 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA MTF2 http://www.ncbi.nlm.nih.gov/gene/22823 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005394 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA MUTED http://www.ncbi.nlm.nih.gov/gene/81567 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005395 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA PAFAH1B2 http://www.ncbi.nlm.nih.gov/gene/5049 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005396 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA PCDHB2 http://www.ncbi.nlm.nih.gov/gene/56133 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005397 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA PDIK1L http://www.ncbi.nlm.nih.gov/gene/149420 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005398 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA PIKFYVE http://www.ncbi.nlm.nih.gov/gene/200576 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005399 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA PPM1A http://www.ncbi.nlm.nih.gov/gene/5494 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005400 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA PYCR2 http://www.ncbi.nlm.nih.gov/gene/29920 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005401 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA RAB3GAP2 http://www.ncbi.nlm.nih.gov/gene/25782 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005402 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA RABGEF1 http://www.ncbi.nlm.nih.gov/gene/27342 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005403 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA RBM12 http://www.ncbi.nlm.nih.gov/gene/10137 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005404 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA RORA http://www.ncbi.nlm.nih.gov/gene/6095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005405 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA RRP15 http://www.ncbi.nlm.nih.gov/gene/51018 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005406 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA SIX4 http://www.ncbi.nlm.nih.gov/gene/51804 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005407 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA SLC35D1 http://www.ncbi.nlm.nih.gov/gene/23169 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005408 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA SLC38A1 http://www.ncbi.nlm.nih.gov/gene/81539 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005409 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA SMC5 http://www.ncbi.nlm.nih.gov/gene/23137 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005410 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA SNX18 http://www.ncbi.nlm.nih.gov/gene/112574 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005411 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA SPN http://www.ncbi.nlm.nih.gov/gene/6693 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005412 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA SPRED1 http://www.ncbi.nlm.nih.gov/gene/161742 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005413 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA ST13 http://www.ncbi.nlm.nih.gov/gene/344328 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005414 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA STMN1 http://www.ncbi.nlm.nih.gov/gene/3925 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005415 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA TBP http://www.ncbi.nlm.nih.gov/gene/6908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005416 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA TET1 http://www.ncbi.nlm.nih.gov/gene/80312 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005417 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA TNRC6B http://www.ncbi.nlm.nih.gov/gene/23112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005418 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA TOMM20 http://www.ncbi.nlm.nih.gov/gene/100129272 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005419 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA TRUB1 http://www.ncbi.nlm.nih.gov/gene/142940 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005420 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA TSPYL1 http://www.ncbi.nlm.nih.gov/gene/7259 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005421 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA UBE2Z http://www.ncbi.nlm.nih.gov/gene/65264 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005422 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA UBXN4 http://www.ncbi.nlm.nih.gov/gene/23190 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005423 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA VAMP3 http://www.ncbi.nlm.nih.gov/gene/9341 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005424 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA VEZT http://www.ncbi.nlm.nih.gov/gene/55591 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005425 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA VPS37C http://www.ncbi.nlm.nih.gov/gene/55048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005426 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA WWTR1 http://www.ncbi.nlm.nih.gov/gene/25937 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005427 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA XPO4 http://www.ncbi.nlm.nih.gov/gene/64328 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005428 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA ZBTB34 http://www.ncbi.nlm.nih.gov/gene/403341 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005429 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA ZBTB39 http://www.ncbi.nlm.nih.gov/gene/9880 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005430 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA ZCCHC3 http://www.ncbi.nlm.nih.gov/gene/85364 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005431 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA ZEB2 http://www.ncbi.nlm.nih.gov/gene/9839 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005432 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA ZNF217 http://www.ncbi.nlm.nih.gov/gene/7764 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005433 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA ZNF395 http://www.ncbi.nlm.nih.gov/gene/55893 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005434 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA ZNF462 http://www.ncbi.nlm.nih.gov/gene/58499 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005435 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA ZNF521 http://www.ncbi.nlm.nih.gov/gene/25925 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005436 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(ebv-mir-bart9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 BC-1 - Host mRNA ZNF621 http://www.ncbi.nlm.nih.gov/gene/285268 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005437 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(miR-BART9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 epithelial cell lines - Host Protein BCL2L11(BimEL) http://www.ncbi.nlm.nih.gov/gene/396632 Downregulation Northern Blot analysis and quantitative RT-PCR, Western Blot analysis, Microarray analysis, ciferase Assays. 21333317 Analysis of the BimEL protein levels in cells expressing the miRNAs revealed that its expression was affected by several of the individual miRNAs with cell lines expressing miR-BART1, 3, 9, 11 and 12 all having decreased BimEL levels (Figure 6B and C). VHID00005438 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(miR-BART9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 epithelial cell lines - Host mRNA BCL2L11(BIM) http://www.ncbi.nlm.nih.gov/gene/396632 Downregulation Northern Blot analysis and quantitative RT-PCR, Western Blot analysis, Microarray analysis, ciferase Assays. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VHID00005439 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(miR-BART9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 nasopharyngeal carcinoma (NPC) cells - Host Protein CDH1 http://www.ncbi.nlm.nih.gov/gene/999 Downregulation Quantitative RT-PCR, Dual luciferase reporter assay,Western blotting,Immunofluorescence,Immunohistochemistry. 24586173 Through biochemical assays and functional rescue analysis, we confirmed that miR-BART9 specifically inhibits E-cadherin to induce a mesenchymal-like phenotype and promote the migration of NPC cells.A previous sequencing study by our group revealed that the EBV miRNA miR-BART9 was expressed at high levels in all EBV-positive NPC tissues.In vivo, we observed that miR-BART9 promoted the metastatic activity of NPC cells in a spontaneous metastasis mouse model. Through bioinformatics analysis and functional verification, we demonstrated that miR-BART9 directly repressed E-cadherin (CDH1). VHID00005440 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(BHRF1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 - - Host Protein BACH1 http://www.ncbi.nlm.nih.gov/gene/571 - PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 For each of them, direct interactions between 3'UTR and EBV miRNAs were confirmed by luciferase assay but no functional assay has been performed so far (Table 2).Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation (PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP) or RNA immunoprecipitation and microarray (RIP-Chip) techniques. Validation of these targets was done using luciferase reporter assays. VHID00005441 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(BHRF1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 - - Host Protein GUF1 http://www.ncbi.nlm.nih.gov/gene/60558 - PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 For each of them, direct interactions between 3'UTR and EBV miRNAs were confirmed by luciferase assay but no functional assay has been performed so far (Table 2).Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation (PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP) or RNA immunoprecipitation and microarray (RIP-Chip) techniques. Validation of these targets was done using luciferase reporter assays. VHID00005442 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(BHRF1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 - - Host Protein NAA30 http://www.ncbi.nlm.nih.gov/gene/122830 - PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 For each of them, direct interactions between 3'UTR and EBV miRNAs were confirmed by luciferase assay but no functional assay has been performed so far (Table 2).Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation (PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP) or RNA immunoprecipitation and microarray (RIP-Chip) techniques. Validation of these targets was done using luciferase reporter assays. VHID00005443 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(BHRF1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 - - Host Protein SCRN1 http://www.ncbi.nlm.nih.gov/gene/9805 - PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 For each of them, direct interactions between 3'UTR and EBV miRNAs were confirmed by luciferase assay but no functional assay has been performed so far (Table 2).Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation (PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP) or RNA immunoprecipitation and microarray (RIP-Chip) techniques. Validation of these targets was done using luciferase reporter assays. VHID00005444 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(BHRF1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 - - Host Protein TP53 http://www.ncbi.nlm.nih.gov/gene/7157 - PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets (Table 1).Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV- and EBV-encoded miRNAs. VHID00005445 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA AKT2 http://www.ncbi.nlm.nih.gov/gene/208 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005446 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA ANKRA2 http://www.ncbi.nlm.nih.gov/gene/57763 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005447 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA ANKRD12 http://www.ncbi.nlm.nih.gov/gene/23253 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005448 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA ANKRD27 http://www.ncbi.nlm.nih.gov/gene/84079 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005449 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA AP1S1 http://www.ncbi.nlm.nih.gov/gene/1174 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005450 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA ARHGEF18 http://www.ncbi.nlm.nih.gov/gene/23370 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005451 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA ASH1L http://www.ncbi.nlm.nih.gov/gene/55870 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005452 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA ATG10 http://www.ncbi.nlm.nih.gov/gene/83734 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005453 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA ATP11B http://www.ncbi.nlm.nih.gov/gene/23200 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005454 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA ATP1B1 http://www.ncbi.nlm.nih.gov/gene/481 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005455 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA B2M http://www.ncbi.nlm.nih.gov/gene/567 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005456 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA BAG5 http://www.ncbi.nlm.nih.gov/gene/9529 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005457 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA C4orf32 http://www.ncbi.nlm.nih.gov/gene/132720 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005458 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA C6orf211 http://www.ncbi.nlm.nih.gov/gene/79624 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005459 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA C6orf61 http://www.ncbi.nlm.nih.gov/gene/254394 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005460 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA C6orf89 http://www.ncbi.nlm.nih.gov/gene/221477 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005461 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA CCDC6 http://www.ncbi.nlm.nih.gov/gene/8030 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005462 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA CDC2 http://www.ncbi.nlm.nih.gov/gene/983 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005463 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA CDC73 http://www.ncbi.nlm.nih.gov/gene/79577 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005464 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA CDK2 http://www.ncbi.nlm.nih.gov/gene/1017 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005465 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA CLOCK http://www.ncbi.nlm.nih.gov/gene/9575 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005466 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA CPD http://www.ncbi.nlm.nih.gov/gene/1362 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005467 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA CPSF7 http://www.ncbi.nlm.nih.gov/gene/79869 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005468 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA CREB3L2 http://www.ncbi.nlm.nih.gov/gene/64764 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005469 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA CSNK1G3 http://www.ncbi.nlm.nih.gov/gene/1456 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005470 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA DAZAP1 http://www.ncbi.nlm.nih.gov/gene/26528 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005471 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA DDX17 http://www.ncbi.nlm.nih.gov/gene/10521 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005472 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA DEXI http://www.ncbi.nlm.nih.gov/gene/28955 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005473 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA DPM1 http://www.ncbi.nlm.nih.gov/gene/8813 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005474 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA EIF2S3 http://www.ncbi.nlm.nih.gov/gene/1968 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005475 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA ELF1 http://www.ncbi.nlm.nih.gov/gene/1997 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005476 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA EPSTI1 http://www.ncbi.nlm.nih.gov/gene/94240 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005477 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA FAM105B http://www.ncbi.nlm.nih.gov/gene/90268 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005478 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA FAM175B http://www.ncbi.nlm.nih.gov/gene/23172 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005479 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA FBXO34 http://www.ncbi.nlm.nih.gov/gene/55030 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005480 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA G3BP1 http://www.ncbi.nlm.nih.gov/gene/10146 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005481 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA GPD2 http://www.ncbi.nlm.nih.gov/gene/2820 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005482 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA GUF1 http://www.ncbi.nlm.nih.gov/gene/60558 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005483 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA HEY1 http://www.ncbi.nlm.nih.gov/gene/23462 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005484 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA HIVEP1 http://www.ncbi.nlm.nih.gov/gene/3096 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005485 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA HMG20A http://www.ncbi.nlm.nih.gov/gene/10363 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005486 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA HUWE1 http://www.ncbi.nlm.nih.gov/gene/10075 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005487 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA IFNGR2 http://www.ncbi.nlm.nih.gov/gene/3460 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005488 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA IGJ http://www.ncbi.nlm.nih.gov/gene/3512 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005489 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA KDM5C http://www.ncbi.nlm.nih.gov/gene/8242 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005490 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA KMT2D(MLL2) - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005491 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA MAGED1 http://www.ncbi.nlm.nih.gov/gene/9500 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005492 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA MMD http://www.ncbi.nlm.nih.gov/gene/23531 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005493 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA NASP http://www.ncbi.nlm.nih.gov/gene/4678 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005494 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA NAT12 http://www.ncbi.nlm.nih.gov/gene/122830 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005495 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA NAV2 http://www.ncbi.nlm.nih.gov/gene/89797 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005496 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA NKRF http://www.ncbi.nlm.nih.gov/gene/55922 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005497 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA NSD1 http://www.ncbi.nlm.nih.gov/gene/64324 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005498 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA NUSAP1 http://www.ncbi.nlm.nih.gov/gene/51203 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005499 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA PAPOLA http://www.ncbi.nlm.nih.gov/gene/10914 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005500 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA PEX26 http://www.ncbi.nlm.nih.gov/gene/55670 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005501 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA PHC3 http://www.ncbi.nlm.nih.gov/gene/80012 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005502 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA PHF20 http://www.ncbi.nlm.nih.gov/gene/51230 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005503 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA PIAS4 http://www.ncbi.nlm.nih.gov/gene/51588 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005504 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA PLAGL2 http://www.ncbi.nlm.nih.gov/gene/5326 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005505 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA POLR2B http://www.ncbi.nlm.nih.gov/gene/5431 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005506 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA PSMD11 http://www.ncbi.nlm.nih.gov/gene/5717 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005507 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA PSMD13 http://www.ncbi.nlm.nih.gov/gene/5719 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005508 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA PTAR1 http://www.ncbi.nlm.nih.gov/gene/375743 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005509 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA RAB11FIP2 http://www.ncbi.nlm.nih.gov/gene/22841 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005510 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA RBPSUH http://www.ncbi.nlm.nih.gov/gene/3516 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005511 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA RERE http://www.ncbi.nlm.nih.gov/gene/473 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005512 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA RFX7 http://www.ncbi.nlm.nih.gov/gene/64864 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005513 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA RNF19A http://www.ncbi.nlm.nih.gov/gene/25897 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005514 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA SCRN1 http://www.ncbi.nlm.nih.gov/gene/9805 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005515 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA SNRPD3 http://www.ncbi.nlm.nih.gov/gene/6634 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005516 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA SPTY2D1 http://www.ncbi.nlm.nih.gov/gene/144108 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005517 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA STAG2 http://www.ncbi.nlm.nih.gov/gene/10735 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005518 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA STARD4 http://www.ncbi.nlm.nih.gov/gene/134429 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005519 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA STARD7 http://www.ncbi.nlm.nih.gov/gene/56910 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005520 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA STOM http://www.ncbi.nlm.nih.gov/gene/2040 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005521 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA SYPL1 http://www.ncbi.nlm.nih.gov/gene/6856 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005522 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA TADA2L http://www.ncbi.nlm.nih.gov/gene/6871 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005523 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA TCERG1 http://www.ncbi.nlm.nih.gov/gene/10915 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005524 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA TECPR1 http://www.ncbi.nlm.nih.gov/gene/25851 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005525 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA TFRC http://www.ncbi.nlm.nih.gov/gene/7037 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005526 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA TMOD2 http://www.ncbi.nlm.nih.gov/gene/29767 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005527 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA TOPORS http://www.ncbi.nlm.nih.gov/gene/10210 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005528 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA TOX4 http://www.ncbi.nlm.nih.gov/gene/9878 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005529 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA TRERF1 http://www.ncbi.nlm.nih.gov/gene/55809 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005530 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA TRIM23 http://www.ncbi.nlm.nih.gov/gene/373 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005531 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA UBR7 http://www.ncbi.nlm.nih.gov/gene/55148 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005532 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA UHMK1 http://www.ncbi.nlm.nih.gov/gene/127933 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005533 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA VPS4B http://www.ncbi.nlm.nih.gov/gene/9525 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005534 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA VRK1 http://www.ncbi.nlm.nih.gov/gene/7443 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005535 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA WNK1 http://www.ncbi.nlm.nih.gov/gene/65125 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005536 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA ZBED4 http://www.ncbi.nlm.nih.gov/gene/9889 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005537 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA ZKSCAN5 http://www.ncbi.nlm.nih.gov/gene/23660 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005538 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(ebv-mir-bhrf1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 Lymphoblastoid cell lines - Host mRNA ZNF227 http://www.ncbi.nlm.nih.gov/gene/7770 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005539 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(mir-BHRF1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 B cell lymphomagenesis - Host mRNA GUF1 http://www.ncbi.nlm.nih.gov/gene/60558 - Western Blotting, Northern Blotting, Luciferase Reporter Assay. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VHID00005540 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-1(mir-BHRF1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001064 B cell lymphomagenesis - Host mRNA SCRN1 http://www.ncbi.nlm.nih.gov/gene/9805 - Western Blotting, Northern Blotting, Luciferase Reporter Assay. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VHID00005541 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(BHRF1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 - - Host Protein BACH1 http://www.ncbi.nlm.nih.gov/gene/571 Downregulation PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets (Table 1).Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV- and EBV-encoded miRNAs. VHID00005542 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(BHRF1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 - - Host Protein KDM4B http://www.ncbi.nlm.nih.gov/gene/23030 - PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 For each of them, direct interactions between 3'UTR and EBV miRNAs were confirmed by luciferase assay but no functional assay has been performed so far (Table 2).Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation (PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP) or RNA immunoprecipitation and microarray (RIP-Chip) techniques. Validation of these targets was done using luciferase reporter assays. VHID00005543 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(BHRF1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 - - Host Protein ZNF451 http://www.ncbi.nlm.nih.gov/gene/26036 - PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 For each of them, direct interactions between 3'UTR and EBV miRNAs were confirmed by luciferase assay but no functional assay has been performed so far (Table 2).Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation (PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP) or RNA immunoprecipitation and microarray (RIP-Chip) techniques. Validation of these targets was done using luciferase reporter assays. VHID00005544 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA ANKRD13A http://www.ncbi.nlm.nih.gov/gene/88455 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005545 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA ARL6IP5 http://www.ncbi.nlm.nih.gov/gene/10550 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005546 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA ASPH http://www.ncbi.nlm.nih.gov/gene/444 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005547 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA CHD4 http://www.ncbi.nlm.nih.gov/gene/1108 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005548 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA CLCN3 http://www.ncbi.nlm.nih.gov/gene/1182 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005549 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA DAZAP1 http://www.ncbi.nlm.nih.gov/gene/26528 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005550 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA DCK http://www.ncbi.nlm.nih.gov/gene/1633 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005551 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA DCTN4 http://www.ncbi.nlm.nih.gov/gene/51164 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005552 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA DHX15 http://www.ncbi.nlm.nih.gov/gene/1665 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005553 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA EPC2 http://www.ncbi.nlm.nih.gov/gene/26122 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005554 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA FNIP2 http://www.ncbi.nlm.nih.gov/gene/57600 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005555 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA HCFC2 http://www.ncbi.nlm.nih.gov/gene/29915 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005556 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA HDAC2 http://www.ncbi.nlm.nih.gov/gene/3066 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005557 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA HIPK2 http://www.ncbi.nlm.nih.gov/gene/653052 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005558 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA IFFO2 http://www.ncbi.nlm.nih.gov/gene/126917 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005559 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA INSIG1 http://www.ncbi.nlm.nih.gov/gene/3638 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005560 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA KLHL5 http://www.ncbi.nlm.nih.gov/gene/51088 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005561 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA LIN54 http://www.ncbi.nlm.nih.gov/gene/132660 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005562 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA MITD1 http://www.ncbi.nlm.nih.gov/gene/129531 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005563 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA MLLT3 http://www.ncbi.nlm.nih.gov/gene/4300 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005564 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA OSBPL3 http://www.ncbi.nlm.nih.gov/gene/26031 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005565 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA PAG1 http://www.ncbi.nlm.nih.gov/gene/55824 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005566 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA PDIK1L http://www.ncbi.nlm.nih.gov/gene/149420 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005567 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA PIP5K2A http://www.ncbi.nlm.nih.gov/gene/5305 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005568 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA PPM1A http://www.ncbi.nlm.nih.gov/gene/5494 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005569 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA PRDM1 http://www.ncbi.nlm.nih.gov/gene/639 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005570 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA PRPF40A http://www.ncbi.nlm.nih.gov/gene/55660 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005571 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA RAPGEF6 http://www.ncbi.nlm.nih.gov/gene/51735 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005572 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA RBM26 http://www.ncbi.nlm.nih.gov/gene/64062 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005573 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA RBM47 http://www.ncbi.nlm.nih.gov/gene/54502 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005574 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA RIPK2 http://www.ncbi.nlm.nih.gov/gene/8767 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005575 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA SEC61G http://www.ncbi.nlm.nih.gov/gene/23480 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005576 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA SERPINB9 http://www.ncbi.nlm.nih.gov/gene/5272 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005577 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA SMAD7 http://www.ncbi.nlm.nih.gov/gene/4092 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005578 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA SPOPL http://www.ncbi.nlm.nih.gov/gene/339745 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005579 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA TBC1D14 http://www.ncbi.nlm.nih.gov/gene/57533 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005580 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA USP42 http://www.ncbi.nlm.nih.gov/gene/84132 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005581 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-2(ebv-mir-bhrf1-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001065 Lymphoblastoid cell lines - Host mRNA ZNF451 http://www.ncbi.nlm.nih.gov/gene/26036 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005582 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-3(BHRF1-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001066 - - Host Protein CXCL11 http://www.ncbi.nlm.nih.gov/gene/6373 - PAR-CLIP,luciferase assays,HITS-CLIP,RIP-Chip. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets (Table 1).Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV- and EBV-encoded miRNAs. VHID00005583 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-3(ebv-mir-bhrf1-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001066 Lymphoblastoid cell lines - Host mRNA ARHGEF2 http://www.ncbi.nlm.nih.gov/gene/9181 - PAR-CLIP. 22291592 We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7). VHID00005584 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-3(ebv-mir-bhrf1-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001066 Lymphoblastoid cell lines - Host mRNA C10orf46 http://www.ncbi.nlm.nih.gov/gene/143384 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005585 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-3(ebv-mir-bhrf1-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001066 Lymphoblastoid cell lines - Host mRNA FBRS http://www.ncbi.nlm.nih.gov/gene/64319 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005586 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-3(ebv-mir-bhrf1-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001066 Lymphoblastoid cell lines - Host mRNA FMNL3 http://www.ncbi.nlm.nih.gov/gene/91010 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005587 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-3(ebv-mir-bhrf1-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001066 Lymphoblastoid cell lines - Host mRNA HDAC1 http://www.ncbi.nlm.nih.gov/gene/3065 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005588 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-3(ebv-mir-bhrf1-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001066 Lymphoblastoid cell lines - Host mRNA MATR3 http://www.ncbi.nlm.nih.gov/gene/9782 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005589 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-3(ebv-mir-bhrf1-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001066 Lymphoblastoid cell lines - Host mRNA MFN1 http://www.ncbi.nlm.nih.gov/gene/55669 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005590 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-3(ebv-mir-bhrf1-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001066 Lymphoblastoid cell lines - Host mRNA NAA50(NAT13) - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005591 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-3(ebv-mir-bhrf1-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001066 Lymphoblastoid cell lines - Host mRNA PTEN http://www.ncbi.nlm.nih.gov/gene/11191 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005592 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-3(ebv-mir-bhrf1-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001066 Lymphoblastoid cell lines - Host mRNA RAP2A http://www.ncbi.nlm.nih.gov/gene/5911 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005593 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-3(ebv-mir-bhrf1-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001066 Lymphoblastoid cell lines - Host mRNA RPL11 http://www.ncbi.nlm.nih.gov/gene/6135 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005594 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-3(ebv-mir-bhrf1-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001066 Lymphoblastoid cell lines - Host mRNA SLC16A6 http://www.ncbi.nlm.nih.gov/gene/9120 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005595 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-3(ebv-mir-bhrf1-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001066 Lymphoblastoid cell lines - Host mRNA VAV2 http://www.ncbi.nlm.nih.gov/gene/7410 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005596 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-3(ebv-mir-bhrf1-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001066 Lymphoblastoid cell lines - Host mRNA WDR45L http://www.ncbi.nlm.nih.gov/gene/56270 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005597 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-3(ebv-mir-bhrf1-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001066 Lymphoblastoid cell lines - Host mRNA ZNF202 http://www.ncbi.nlm.nih.gov/gene/7753 - PAR-CLIP. 22291592 We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs. VHID00005598 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-3(miR-BHRF1-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001066 T cells - Host mRNA CXCL11 http://www.ncbi.nlm.nih.gov/gene/6373 Downregulation - 19158788 The final known example of a cellular gene product downregulated by a viral miRNA is provided by CXCL-11, also called I-TAC, an interferon-inducible chemokine that acts as an attractant for T-cells. The mRNA encoding CXCL-11 is downregulated by EBV miR-BHRF1-3, which is expressed at high levels in many B cell tumors induced by EBV. VHID00005599 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-3(mir-BHRF1-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001066 - - Host Protein CXCL11 http://www.ncbi.nlm.nih.gov/gene/6373 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00005600 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-bart7* # BC-1 - Host mRNA TAF2 http://www.ncbi.nlm.nih.gov/gene/6873 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005601 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-bart7* # BC-1 - Host mRNA TGIF2 http://www.ncbi.nlm.nih.gov/gene/60436 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005602 Herpes simplex virus 1(HSV-1) Chlorocebus sabaeus Virus miRNA hsv1-mir-H27 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0024977 African green monkey kidney cells - Host mRNA KLHL24 http://www.ncbi.nlm.nih.gov/gene/103221166 Downregulation Western blot,Quantitative real-time PCR. 23512275 We demonstrate that a miRNA, hsv1-mir-H27, encoded within the genome of herpes simplex virus 1 (HSV-1), targets the mRNA of the cellular transcriptional repressor Kelch-like 24 (KLHL24) that inhibits transcriptional efficiency of viral immediate-early and early genes. The viral miRNA is able to block the expression of KLHL24 in cells infected by HSV-1. . VHID00005603 Herpes simplex virus 1(HSV-1) Homo sapiens Virus miRNA hsv1-mir-LAT(miR-LAT) # Sensory neurons - Host Protein SMAD3 http://www.ncbi.nlm.nih.gov/gene/4088 Downregulation Reporter assays,RT-PCR,Northern blotting and Western analysis. 16738545 miR-LAT exerts its anti-apoptotic effect by downregulation of transforming growth factor(TGF)-beta 1 and SMAD3 expression, both of which are functionally linked in the TGF-beta pathway. VHID00005604 Herpes simplex virus 1(HSV-1) Homo sapiens Virus miRNA hsv1-mir-LAT(miR-LAT) # Sensory neurons - Host Protein TGFB1(TGF-beta) http://www.ncbi.nlm.nih.gov/gene/7040 Downregulation Reporter assays,RT-PCR,Northern blotting and Western analysis. 16738545 miR-LAT exerts its anti-apoptotic effect by downregulation of transforming growth factor(TGF)-beta 1 and SMAD3 expression, both of which are functionally linked in the TGF-beta pathway. VHID00005605 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR 1 http://lncrnadb.com/Detail.aspx?TKeyID=240 marmoset T cells - Host miRNA miR-27 - Downregulation HITS-CLIP, mRNA-Seq, Luciferase Reporter Assays, Western Blot Analysis, Enzyme-Linked Immunosorbent Assay. 24725595 In marmoset T cells transformed by Herpesvirus saimiri (HVS), a viral U-rich noncoding (nc) RNA, HSUR 1, specifically mediates degradation of host microRNA-27 (miR-27). High-throughput sequencing of RNA after crosslinking immunoprecipitation (HITS-CLIP) identified mRNAs targeted by miR-27 as enriched in the T cell receptor (TCR) signaling pathway, including GRB2. VHID00005606 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR1 http://lncrnadb.com/Detail.aspx?TKeyID=240 - - Host Protein ELAVL1(HuR) http://www.ncbi.nlm.nih.gov/gene/101036795 - Transient-transfection and immunoprecipitation of HSURs. 15632062 HSURs 1, 2, and 5 have been shown to contain destabilizing AU-rich elements (AREs) at their 5' ends that interact with the ARE-binding protein HuR . VHID00005607 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR1 http://lncrnadb.com/Detail.aspx?TKeyID=240 HeLa cell line - Host Protein SMN1(SMN) http://www.ncbi.nlm.nih.gov/gene/101028267 - Purification and analysis of native SMN complex, Transient-transfection and immunoprecipitation of HSURs, Indirect immunofluorescence. 15632062 HVS encodes seven small RNAs (HSURs) of unknown function. The HSURs acquire host Sm proteins and assemble Sm cores similar to those found on the spliceosomal small nuclear RNPs (snRNPs). Here we show that, like host snRNPs, HSURs use the SMN (survival of motor neurons) complex to assemble Sm cores. As shown in Fig.1B, HSURs 1, 3, 4, and 5 bound specifically and efficiently to the SMN complex. VHID00005608 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR1 http://lncrnadb.com/Detail.aspx?TKeyID=240 HeLa cells - Host Protein ELAVL1(HuR) http://www.ncbi.nlm.nih.gov/gene/101036795 - Whole cell run-on assays, RNase protection and primer extension assays, Immunoprecipitation of HSURs, UV cross-linking competition assays. 9334320 The viral small nuclear RNA (snRNA) Herpesvirus saimiri U RNA 1 (HSUR 1) also contains an AUUUA-rich sequence. This ARE induces rapid degradation of HSUR 1 itself and of other snRNAs including HSUR 2 and cellular U1. Moreover,the in vivo degradation activity of mutant AREs correlates with their in vitro binding to the HuR protein, implicated previously as a component of the mRNA degradation machinery. VHID00005609 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR1 http://lncrnadb.com/Detail.aspx?TKeyID=240 Marmoset T cells - Host Protein CD52 # - Microarray, Northern analyses. 15916956 The Herpesvirus saimiri U RNAs (HSURs) are the most abundant viral transcripts in HVS-transformed, latently infected T cells but are not required for viral replication or transformation in vitro. Microarray and Northern analyses reveal that HSUR 1 and 2 expression correlates with significant increases in a small number of host mRNAs, including the T cell-receptor beta and gamma chains, the T cell and natural killer(NK) cell-surface receptors CD52 and DAP10, and intracellular proteins--SKAP55, granulysin, and NKG7--linked to T cell and NK cell activation. VHID00005610 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR1 http://lncrnadb.com/Detail.aspx?TKeyID=240 Marmoset T cells - Host Protein DAP10 # - Microarray, Northern analyses. 15916956 The Herpesvirus saimiri U RNAs (HSURs) are the most abundant viral transcripts in HVS-transformed, latently infected T cells but are not required for viral replication or transformation in vitro. Microarray and Northern analyses reveal that HSUR 1 and 2 expression correlates with significant increases in a small number of host mRNAs, including the T cell-receptor beta and gamma chains, the T cell and natural killer(NK) cell-surface receptors CD52 and DAP10, and intracellular proteins--SKAP55, granulysin, and NKG7--linked to T cell and NK cell activation. VHID00005611 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR1 http://lncrnadb.com/Detail.aspx?TKeyID=240 Marmoset T cells - Host Protein Granulysin # - Microarray, Northern analyses. 15916956 The Herpesvirus saimiri U RNAs (HSURs) are the most abundant viral transcripts in HVS-transformed, latently infected T cells but are not required for viral replication or transformation in vitro. Microarray and Northern analyses reveal that HSUR 1 and 2 expression correlates with significant increases in a small number of host mRNAs, including the T cell-receptor beta and gamma chains, the T cell and natural killer(NK) cell-surface receptors CD52 and DAP10, and intracellular proteins--SKAP55, granulysin, and NKG7--linked to T cell and NK cell activation. VHID00005612 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR1 http://lncrnadb.com/Detail.aspx?TKeyID=240 Marmoset T cells - Host Protein LOC101042301(Sm) http://www.ncbi.nlm.nih.gov/gene/101042301 - 5' End Determination of HSURs, RNAase T 1 Protection Assay, Plasmids and M13 Constructs, Gel Electrophoresis. 2842058 Four novel U RNAs are encoded by a herpesvirus. Marmoset T lymphocytes transformed by herpesvirus saimiri contain the first virally encoded U RNAs (called HSURs) to be identified. HSURs bind proteins with Sm determinants and acquire a 5' trimethylguanosine cap structure. VHID00005613 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR1 http://lncrnadb.com/Detail.aspx?TKeyID=240 Marmoset T cells - Host Protein NKG7 http://www.ncbi.nlm.nih.gov/gene/100410802 - Microarray, Northern analyses. 15916956 The Herpesvirus saimiri U RNAs (HSURs) are the most abundant viral transcripts in HVS-transformed, latently infected T cells but are not required for viral replication or transformation in vitro. Microarray and Northern analyses reveal that HSUR 1 and 2 expression correlates with significant increases in a small number of host mRNAs, including the T cell-receptor beta and gamma chains, the T cell and natural killer(NK) cell-surface receptors CD52 and DAP10, and intracellular proteins--SKAP55, granulysin, and NKG7--linked to T cell and NK cell activation. VHID00005614 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR1 http://lncrnadb.com/Detail.aspx?TKeyID=240 Marmoset T cells - Host Protein SKAP55 # - Microarray, Northern analyses. 15916956 The Herpesvirus saimiri U RNAs (HSURs) are the most abundant viral transcripts in HVS-transformed, latently infected T cells but are not required for viral replication or transformation in vitro. Microarray and Northern analyses reveal that HSUR 1 and 2 expression correlates with significant increases in a small number of host mRNAs, including the T cell-receptor beta and gamma chains, the T cell and natural killer(NK) cell-surface receptors CD52 and DAP10, and intracellular proteins--SKAP55, granulysin, and NKG7--linked to T cell and NK cell activation. VHID00005615 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR1 http://lncrnadb.com/Detail.aspx?TKeyID=240 Marmoset T cells - Host Protein TCR # - Microarray, Northern analyses. 15916956 The Herpesvirus saimiri U RNAs (HSURs) are the most abundant viral transcripts in HVS-transformed, latently infected T cells but are not required for viral replication or transformation in vitro. Microarray and Northern analyses reveal that HSUR 1 and 2 expression correlates with significant increases in a small number of host mRNAs, including the T cell-receptor beta and gamma chains, the T cell and natural killer(NK) cell-surface receptors CD52 and DAP10, and intracellular proteins--SKAP55, granulysin, and NKG7--linked to T cell and NK cell activation. VHID00005616 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR1 http://lncrnadb.com/Detail.aspx?TKeyID=240 marmoset T cells - Host miRNA miR-27 # Downregulation Mutational analyses. 21139068 Mutational analyses demonstrated that the binding of miR-27 to HSUR1 and that of miR-16 to HSUR2 involves base pairing.Transient knockdown and ectopic expression of HSUR1 demonstrated that degradation of mature miR-27 occurs in a sequence-specific. VHID00005617 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR1 http://lncrnadb.com/Detail.aspx?TKeyID=240 marmoset T-cell line Downregulation Host miRNA miR-142-3p # Downregulation Coimmunoprecipitation experiments, Quantitative real-time polymerase chain reaction (PCR), synthetic miRNA duplexes. 20558719 Bioinformatic searches then revealed complementarity between these HSUR sequences and three microRNAs(miRNAs) expressed in T cells: miR-142-3p, miR-27, and miR-16. VHID00005618 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR1 http://lncrnadb.com/Detail.aspx?TKeyID=240 marmoset T-cell line Downregulation Host miRNA miR-16 # Downregulation Coimmunoprecipitation experiments, Quantitative real-time polymerase chain reaction (PCR), synthetic miRNA duplexes. 20558719 Bioinformatic searches then revealed complementarity between these HSUR sequences and three microRNAs(miRNAs) expressed in T cells: miR-142-3p, miR-27, and miR-16. VHID00005619 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR1 http://www.lncrnadb.org/Detail.aspx?TKeyID=240 marmoset T-cell line Downregulation Host miRNA miR-27 # Downregulation Coimmunoprecipitation experiments, Quantitative real-time polymerase chain reaction (PCR), synthetic miRNA duplexes. 20558719 Coimmunoprecipitation experiments confirmed that HSURs 1 and 2 interact with the predicted miRNAs in virally transformed T cells. The abundance of one of these miRNAs, miR-27, is dramatically lowered in transformed cells, with consequent effects on the expression of miR-27 target genes. Transient knockdown and ectopic expression of HSUR 1 demonstrate that it directs degradation of mature miR-27 in a sequence-specific and binding-dependent manner. VHID00005620 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR2 http://lncrnadb.com/Detail.aspx?TKeyID=240 - - Host Protein ELAVL1(HuR) http://www.ncbi.nlm.nih.gov/gene/101036795 - Transient-transfection and immunoprecipitation of HSURs. 15632062 HSURs 1, 2, and 5 have been shown to contain destabilizing AU-rich elements (AREs) at their 5' ends that interact with the ARE-binding protein HuR . VHID00005621 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR2 http://lncrnadb.com/Detail.aspx?TKeyID=240 Jurkat T cells - Host Protein AUBF70 # - Band-shift assays, Polymerase chain reaction, Northern blots, Analytical SDS-PAGE electrophoresis. 7733817 Herpesvirus saimiri (H. saimiri) can transform T lymphocytes and cause lymphoid tumors in rabbits and New World monkeys. Jurkat T cells express a 70 kD RNA binding factor (AUBF70) which binds HSUR2. VHID00005622 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR2 http://lncrnadb.com/Detail.aspx?TKeyID=240 Marmoset T cells - Host Protein CD52 # - Microarray, Northern analyses. 15916956 The Herpesvirus saimiri U RNAs (HSURs) are the most abundant viral transcripts in HVS-transformed, latently infected T cells but are not required for viral replication or transformation in vitro. Microarray and Northern analyses reveal that HSUR 1 and 2 expression correlates with significant increases in a small number of host mRNAs, including the T cell-receptor beta and gamma chains, the T cell and natural killer(NK) cell-surface receptors CD52 and DAP10, and intracellular proteins--SKAP55, granulysin, and NKG7--linked to T cell and NK cell activation. VHID00005623 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR2 http://lncrnadb.com/Detail.aspx?TKeyID=240 Marmoset T cells - Host Protein DAP10 # - Microarray, Northern analyses. 15916956 The Herpesvirus saimiri U RNAs (HSURs) are the most abundant viral transcripts in HVS-transformed, latently infected T cells but are not required for viral replication or transformation in vitro. Microarray and Northern analyses reveal that HSUR 1 and 2 expression correlates with significant increases in a small number of host mRNAs, including the T cell-receptor beta and gamma chains, the T cell and natural killer(NK) cell-surface receptors CD52 and DAP10, and intracellular proteins--SKAP55, granulysin, and NKG7--linked to T cell and NK cell activation. VHID00005624 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR2 http://lncrnadb.com/Detail.aspx?TKeyID=240 Marmoset T cells - Host Protein Granulysin # - Microarray, Northern analyses. 15916956 The Herpesvirus saimiri U RNAs (HSURs) are the most abundant viral transcripts in HVS-transformed, latently infected T cells but are not required for viral replication or transformation in vitro. Microarray and Northern analyses reveal that HSUR 1 and 2 expression correlates with significant increases in a small number of host mRNAs, including the T cell-receptor beta and gamma chains, the T cell and natural killer(NK) cell-surface receptors CD52 and DAP10, and intracellular proteins--SKAP55, granulysin, and NKG7--linked to T cell and NK cell activation. VHID00005625 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR2 http://lncrnadb.com/Detail.aspx?TKeyID=240 Marmoset T cells - Host Protein LOC101042301(Sm) http://www.ncbi.nlm.nih.gov/gene/101042301 - 5' End Determination of HSURs, RNAase T 1 Protection Assay, Plasmids and M13 Constructs, Gel Electrophoresis. 2842058 Four novel U RNAs are encoded by a herpesvirus. Marmoset T lymphocytes transformed by herpesvirus saimiri contain the first virally encoded U RNAs (called HSURs) to be identified. HSURs bind proteins with Sm determinants and acquire a 5' trimethylguanosine cap structure. VHID00005626 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR2 http://lncrnadb.com/Detail.aspx?TKeyID=240 Marmoset T cells - Host Protein NKG7 http://www.ncbi.nlm.nih.gov/gene/100410802 - Microarray, Northern analyses. 15916956 The Herpesvirus saimiri U RNAs (HSURs) are the most abundant viral transcripts in HVS-transformed, latently infected T cells but are not required for viral replication or transformation in vitro. Microarray and Northern analyses reveal that HSUR 1 and 2 expression correlates with significant increases in a small number of host mRNAs, including the T cell-receptor beta and gamma chains, the T cell and natural killer(NK) cell-surface receptors CD52 and DAP10, and intracellular proteins--SKAP55, granulysin, and NKG7--linked to T cell and NK cell activation. VHID00005627 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR2 http://lncrnadb.com/Detail.aspx?TKeyID=240 Marmoset T cells - Host Protein SKAP55 # - Microarray, Northern analyses. 15916956 The Herpesvirus saimiri U RNAs (HSURs) are the most abundant viral transcripts in HVS-transformed, latently infected T cells but are not required for viral replication or transformation in vitro. Microarray and Northern analyses reveal that HSUR 1 and 2 expression correlates with significant increases in a small number of host mRNAs, including the T cell-receptor beta and gamma chains, the T cell and natural killer(NK) cell-surface receptors CD52 and DAP10, and intracellular proteins--SKAP55, granulysin, and NKG7--linked to T cell and NK cell activation. VHID00005628 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR2 http://lncrnadb.com/Detail.aspx?TKeyID=240 Marmoset T cells - Host Protein TCR # - Microarray, Northern analyses. 15916956 The Herpesvirus saimiri U RNAs (HSURs) are the most abundant viral transcripts in HVS-transformed, latently infected T cells but are not required for viral replication or transformation in vitro. Microarray and Northern analyses reveal that HSUR 1 and 2 expression correlates with significant increases in a small number of host mRNAs, including the T cell-receptor beta and gamma chains, the T cell and natural killer(NK) cell-surface receptors CD52 and DAP10, and intracellular proteins--SKAP55, granulysin, and NKG7--linked to T cell and NK cell activation. VHID00005629 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR2 http://lncrnadb.com/Detail.aspx?TKeyID=240 marmoset T cells - Host miRNA miR-16 # - Mutational analyses. 21139068 Mutational analyses demonstrated that the binding of miR-27 to HSUR1 and that of miR-16 to HSUR2 involves base pairing.Transient knockdown and ectopic expression of HSUR1 demonstrated that degradation of mature miR-27 occurs in a sequence-specific. VHID00005630 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR2 http://lncrnadb.com/Detail.aspx?TKeyID=240 marmoset T-cell line Downregulation Host miRNA miR-142-3p # Downregulation Coimmunoprecipitation experiments, Quantitative real-time polymerase chain reaction (PCR), synthetic miRNA duplexes. 20558719 Bioinformatic searches then revealed complementarity between these HSUR sequences and three microRNAs(miRNAs) expressed in T cells: miR-142-3p, miR-27, and miR-16. VHID00005631 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR2 http://lncrnadb.com/Detail.aspx?TKeyID=240 marmoset T-cell line Downregulation Host miRNA miR-16 # Downregulation Coimmunoprecipitation experiments, Quantitative real-time polymerase chain reaction (PCR), synthetic miRNA duplexes. 20558719 Bioinformatic searches then revealed complementarity between these HSUR sequences and three microRNAs(miRNAs) expressed in T cells: miR-142-3p, miR-27, and miR-16. VHID00005632 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR2 http://lncrnadb.com/Detail.aspx?TKeyID=240 marmoset T-cell line Downregulation Host miRNA miR-27 # Downregulation Coimmunoprecipitation experiments, Quantitative real-time polymerase chain reaction (PCR), synthetic miRNA duplexes. 20558719 Coimmunoprecipitation experiments confirmed that HSURs 1 and 2 interact with the predicted miRNAs in virally transformed T cells. The abundance of one of these miRNAs, miR-27, is dramatically lowered in transformed cells, with consequent effects on the expression of miR-27 target genes. Transient knockdown and ectopic expression of HSUR 1 demonstrate that it directs degradation of mature miR-27 in a sequence-specific and binding-dependent manner. VHID00005633 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR3 # HeLa cell line - Host Protein SMN1(SMN) http://www.ncbi.nlm.nih.gov/gene/101028267 - Purification and analysis of native SMN complex, Transient-transfection and immunoprecipitation of HSURs, indirect immunofluorescence, In situ hybridization. 15632062 HVS encodes seven small RNAs (HSURs) of unknown function. The HSURs acquire host Sm proteins and assemble Sm cores similar to those found on the spliceosomal small nuclear RNPs (snRNPs). Here we show that, like host snRNPs, HSURs use the SMN (survival of motor neurons) complex to assemble Sm cores. As shown in Fig.1B, HSURs 1, 3, 4, and 5 bound specifically and efficiently to the SMN complex. VHID00005634 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR3 # Marmoset T cells - Host Protein LOC101042301(Sm) http://www.ncbi.nlm.nih.gov/gene/101042301 - 5' End Determination of HSURs, RNAase T 1 Protection Assay, Plasmids and M13 Constructs, Gel Electrophoresis. 2842058 Four novel U RNAs are encoded by a herpesvirus. Marmoset T lymphocytes transformed by herpesvirus saimiri contain the first virally encoded U RNAs (called HSURs) to be identified. HSURs bind proteins with Sm determinants and acquire a 5' trimethylguanosine cap structure. VHID00005635 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR4 # HeLa cell line - Host Protein SMN1(SMN) http://www.ncbi.nlm.nih.gov/gene/101028267 - Purification and analysis of native SMN complex, Transient-transfection and immunoprecipitation of HSURs, indirect immunofluorescence, In situ hybridization. 15632062 HVS encodes seven small RNAs (HSURs) of unknown function. The HSURs acquire host Sm proteins and assemble Sm cores similar to those found on the spliceosomal small nuclear RNPs (snRNPs). Here we show that, like host snRNPs, HSURs use the SMN (survival of motor neurons) complex to assemble Sm cores. As shown in Fig.1B, HSURs 1, 3, 4, and 5 bound specifically and efficiently to the SMN complex. VHID00005636 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR4 # Marmoset T cells - Host Protein LOC101042301(Sm) http://www.ncbi.nlm.nih.gov/gene/101042301 - 5' End Determination of HSURs, RNAase T 1 Protection Assay, Plasmids and M13 Constructs, Gel Electrophoresis. 2842058 Four novel U RNAs are encoded by a herpesvirus. Marmoset T lymphocytes transformed by herpesvirus saimiri contain the first virally encoded U RNAs (called HSURs) to be identified. HSURs bind proteins with Sm determinants and acquire a 5' trimethylguanosine cap structure. VHID00005637 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR5 # - - Host Protein ELAVL1(HuR) http://www.ncbi.nlm.nih.gov/gene/101036795 - Transient-transfection and immunoprecipitation of HSURs. 15632062 HSURs 1, 2, and 5 have been shown to contain destabilizing AU-rich elements (AREs) at their 5' ends that interact with the ARE-binding protein HuR . VHID00005638 Herpesvirus saimiri(HVS) Callithrix jacchus Virus LncRNA HSUR5 # HeLa cell line - Host Protein SMN1(SMN) http://www.ncbi.nlm.nih.gov/gene/101028267 - Purification and analysis of native SMN complex, Transient-transfection and immunoprecipitation of HSURs, indirect immunofluorescence, In situ hybridization. 15632062 HVS encodes seven small RNAs (HSURs) of unknown function. The HSURs acquire host Sm proteins and assemble Sm cores similar to those found on the spliceosomal small nuclear RNPs (snRNPs). Here we show that, like host snRNPs, HSURs use the SMN (survival of motor neurons) complex to assemble Sm cores. As shown in Fig.1B, HSURs 1, 3, 4, and 5 bound specifically and efficiently to the SMN complex. VHID00005639 Herpesvirus saimiri(HVS) Saimiri boliviensis Virus LncRNA HSUR1 http://www.lncrnadb.org/Detail.aspx?TKeyID=240 - - Host Protein LOC101042301(Sm) http://www.ncbi.nlm.nih.gov/gene/101042301 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00005640 Herpesvirus saimiri(HVS) Saimiri boliviensis Virus LncRNA HSUR2 http://lncrnadb.com/Detail.aspx?TKeyID=240 - - Host Protein LOC101042301(Sm) http://www.ncbi.nlm.nih.gov/gene/101042301 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00005641 Herpesvirus saimiri(HVS) Saimiri boliviensis Virus LncRNA HSUR3 # - - Host Protein LOC101042301(Sm) http://www.ncbi.nlm.nih.gov/gene/101042301 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00005642 Herpesvirus saimiri(HVS) Saimiri boliviensis Virus LncRNA HSUR4 # - - Host Protein LOC101042301(Sm) http://www.ncbi.nlm.nih.gov/gene/101042301 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00005643 Herpesvirus saimiri(HVS) Saimiri boliviensis Virus LncRNA HSUR5 # - - Host Protein LOC101042301(Sm) http://www.ncbi.nlm.nih.gov/gene/101042301 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00005644 Herpesvirus saimiri(HVS) Saimiri boliviensis Virus LncRNA HSUR6 # - - Host Protein LOC101042301(Sm) http://www.ncbi.nlm.nih.gov/gene/101042301 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00005645 Herpesvirus saimiri(HVS) Saimiri boliviensis Virus LncRNA HSUR7 # - - Host Protein LOC101042301(Sm) http://www.ncbi.nlm.nih.gov/gene/101042301 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. table 1 Viral ncRNAs excluding miRNAs. VHID00005646 Human cytomegalovirus(HCMV) Homo sapiens Virus LncRNA Beta2.7 http://lncrnadb.com/Detail.aspx?TKeyID=223 - - Host Protein GRIM-19 http://www.ncbi.nlm.nih.gov/gene/51079 - Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 Assigning functions to cellular ncRNAs is not straightforward(in contrast to mRNAs), and viral ncRNAs present even more challenging problems. Here, we review current insights into the roles of viral ncRNPs and how they relate to the viral takeover agenda. Table 1 Viral ncRNAs excluding miRNAs. VHID00005647 Human cytomegalovirus(HCMV) Homo sapiens Virus LncRNA beta2.7 http://lncrnadb.com/Detail.aspx?TKeyID=223 Neuronal U373 cells - Host Protein Complex I # - - 17540903 During infection, beta2.7 RNA interacted with complex I and prevented the relocalization of the essential subunit genes associated with retinoid/interferon-induced mortality-19, in response to apoptotic stimuli. ComplexI targeting by a viral RNA represents a refined strategy to modulate the metabolic viability of the infected host cell. VHID00005648 Human cytomegalovirus(HCMV) Homo sapiens Virus LncRNA beta2.7 http://lncrnadb.com/Detail.aspx?TKeyID=223 Neuronal U373 cells - Host Protein NDUFA13(GRIM-19) http://www.ncbi.nlm.nih.gov/gene/51079 - - 17540903 During infection, beta2.7 RNA interacted with complex I and prevented the relocalization of the essential subunit genes associated with retinoid/interferon-induced mortality-19, in response to apoptotic stimuli. ComplexI targeting by a viral RNA represents a refined strategy to modulate the metabolic viability of the infected host cell. One role of the HCMV beta2.7 transcript may be to mediate protection of the cell from apoptotic pathways activated by metabolic stress of complex I. Genes associated with retinoid/interferon-induced mortality (GRIM)-19 is a subunit of complex I that is essential for its assembly and function. VHID00005649 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-miR-US25-2-3p(miR-US25-2-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001583 MRC-5 cells Upregulation Host Protein EIF4A1(eIF4A1) http://www.ncbi.nlm.nih.gov/gene/1973 Downregulation Microarray analysis. 23747307 In our study, eukaryotic translation initiation factor 4A1 (eIF4A1) was identified to be a direct target of miR-US25-2-3p. Small interfering RNA (siRNA) and miR-US25-2-3p mediated eIF4A1 knockdown experiments revealed that high level of miR-US25-2-3p in MRC-5 cells decreased HCMV and host genomic DNA synthesis, and inhibited cap-dependent translation and host cell proliferation. However, eIF4A1 up-regulation induced by miR-US25-2-3p inhibitor increased HCMV copy number. VHID00005650 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 - - Host Protein MICB http://www.ncbi.nlm.nih.gov/gene/4277 Downregulation An algorithm for the prediction of miRNA targets, miRNA-based immunoevasion mechanism. 17641203 We show that hcmv-miR-UL112 specifically down-regulates MICB expression during viral infection. VHID00005651 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 - - Host Protein MICB http://www.ncbi.nlm.nih.gov/gene/4277 Downregulation Luciferase assay, Computational predictions, Western blotting, Real-time PCR analysis, FACS staining. 19656885 Indeed, we have previously demonstrated that a human cytomegalovirus (HCMV)-encoded miRNA, miR-UL112, downregulates the expression of a host immune gene, MICB. VHID00005652 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 - - Host mRNA MICB http://www.ncbi.nlm.nih.gov/gene/4277 Downregulation - 19158788 One reported target for hCMV miR-UL112-1 is MICB, a natural killer (NK) cell ligand that plays a key role in NK cell killing of virus-infected cells. VHID00005653 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 NK cells - Host mRNA MICB http://www.ncbi.nlm.nih.gov/gene/4277 Downregulation - 22568714 Table2. Human CMV miRNAs and their functions. Inhibits HCMV IE1 gene expression, and acts as an immune response inhibitor to help viral replication.Inhibits HCMV IE1gene expression, and acts as an immune response inhibitor to help viral replication Specifically downregulates MICB expression during viral infection, leading to decreased binding of NKG2D and reduced killing by NK cells. VHID00005654 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112(hcmv-miR-UL112-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 - - Host mRNA MICB http://www.ncbi.nlm.nih.gov/gene/4277 - Quantitative Real-Time PCR, Luciferase Assay, Western Blot. 20413099 Recently, the activating NK cell ligand MICB was found to be targeted by both ebv-miR-BART2-5p, kshv-miR-K12-7 and hcmv-miR-UL112-1. VHID00005655 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112(miR-UL112) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 - - Host Protein MICB http://www.ncbi.nlm.nih.gov/gene/4277 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00005656 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112(miR-UL112) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 - - Host mRNA MICB http://www.ncbi.nlm.nih.gov/gene/4277 Downregulation Quantitative Real-Time PCR, Luciferase Assay, Western Blot. 19380116 Indeed, we have recently shown that an HCMV miRNA, miR-UL112, downregulates MICB expression, thus leading to the reduced killing of infected cells by NK cells. VHID00005657 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112(miR-UL112-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 - - Host mRNA MICB http://www.ncbi.nlm.nih.gov/gene/4277 - Luciferase assay, Western blot analysis, miRNA expression cassettes, Sequence analysis, miR-US25-1 KO virus, RT-PCR analysis, RNA induced silencing complex immunoprecipitation(RISC-IP) techniques. 20585629 In addition, miR-UL112-1 targets the cellular gene MICB, resulting in protection against recognition by natural killer cells . VHID00005658 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112-1(hcmv-miR-UL112-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 Human embryonic kidney 293(HEK293) cells - Host Protein IL32(IL-32) http://www.ncbi.nlm.nih.gov/gene/9235 Downregulation Semi-quantitative RT-PC, TaqMan? miRNA assays, Luciferase assay, Western blot. 23402302 IL-32 expression was induced by active HCMV infection and could be functionally down-regulated by ectopically expressed hcmv-miR-UL112-1. . VHID00005659 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL148D http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001681 Human embryonic kidney 293(HEK293) cells - Host Protein IER3(IEX-1) http://www.ncbi.nlm.nih.gov/gene/8870 Downregulation Western blot analysis, Luciferase reporter assay, Hybrid-PCR. 23403649 HCMV(Human cytomegalovirus) encodes at least 14 miRNAs, including hcmv-mir-UL148D, which resides in the HCMV UL/b' region. In vitro system of human embryonic kidney 293(HEK293) cells, the ectopically expressed hcmv-mir-UL148D exhibited a downregulatory effect on IEX-1 expression, and decreased the cell apoptosis induced by transfected IEX-1. VHID00005660 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL148D http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001681 human embryonic kidney 293 (HEK293) cells - Host Protein IER3(IEX-1) http://www.ncbi.nlm.nih.gov/gene/8870 Downregulation hybrid-PCR screening,dual luciferase reporter assay, western blot analysis,apoptosis assay. 23403649 In this study, hybrid-PCR screening was used to identify target genes and dual luciferase reporter assay was used to evaluate the binding effect of hcmv-miR-UL148D to the 3' untranslated region (3'UTR) of IEX-1. VHID00005661 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA CCNE2 http://www.ncbi.nlm.nih.gov/gene/9134 Downregulation - 22568714 Table2. Human CMV miRNAs and their functions. Inhibits HCMV IE1 gene expression, and acts as an immune response inhibitor to help viral replication.Inhibits HCMV IE1gene expression, and acts as an immune response inhibitor to help viral replication Specifically downregulates MICB expression during viral infection, leading to decreased binding of NKG2D and reduced killing by NK cells. VHID00005662 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA H3F3B http://www.ncbi.nlm.nih.gov/gene/3021 Downregulation - 22568714 Table2. Human CMV miRNAs and their functions. Inhibits HCMV IE1 gene expression, and acts as an immune response inhibitor to help viral replication.Inhibits HCMV IE1gene expression, and acts as an immune response inhibitor to help viral replication Specifically downregulates MICB expression during viral infection, leading to decreased binding of NKG2D and reduced killing by NK cells. VHID00005663 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA TRIM28 http://www.ncbi.nlm.nih.gov/gene/10155 Downregulation - 22568714 Table2. Human CMV miRNAs and their functions. Inhibits HCMV IE1 gene expression, and acts as an immune response inhibitor to help viral replication.Inhibits HCMV IE1gene expression, and acts as an immune response inhibitor to help viral replication Specifically downregulates MICB expression during viral infection, leading to decreased binding of NKG2D and reduced killing by NK cells. VHID00005664 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host Protein CCNE2 http://www.ncbi.nlm.nih.gov/gene/9134 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00005665 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host Protein H3F3B http://www.ncbi.nlm.nih.gov/gene/3021 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00005666 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host Protein TRIM28 http://www.ncbi.nlm.nih.gov/gene/10155 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00005667 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA ASPSCR1 http://www.ncbi.nlm.nih.gov/gene/79058 - Luciferase assay. 20585629 Top 20 ranked cellular targets of miR-US25-1(Table 1). VHID00005668 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA ASRGL1 http://www.ncbi.nlm.nih.gov/gene/80150 - Luciferase assay. 20585629 Top 20 ranked cellular targets of miR-US25-1(Table 1). VHID00005669 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA ATP6V0C http://www.ncbi.nlm.nih.gov/gene/527 - Luciferase assay. 20585629 Top 20 ranked cellular targets of miR-US25-1(Table 1). VHID00005670 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA BCKDHA http://www.ncbi.nlm.nih.gov/gene/593 - Luciferase assay. 20585629 Top 20 ranked cellular targets of miR-US25-1(Table 1). VHID00005671 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA BLVRA http://www.ncbi.nlm.nih.gov/gene/644 - Luciferase assay. 20585629 Top 20 ranked cellular targets of miR-US25-1(Table 1). VHID00005672 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA BRCC3 http://www.ncbi.nlm.nih.gov/gene/79184 Downregulation Luciferase assay, Western blot analysis, miRNA expression cassettes, Sequence analysis, miR-US25-1 KO virus, RT-PCR analysis, RNA induced silencing complex immunoprecipitation(RISC-IP) techniques. 20585629 Intriguingly,many of the genes targeted by miR-US25-1 are associated with cell cycle control, including cyclin E2, BRCC3, EID1, MAPRE2, and CD147, suggesting that miR-US25-1 is targeting genes within a related pathway. VHID00005673 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA CCDC58 http://www.ncbi.nlm.nih.gov/gene/131076 - Luciferase assay. 20585629 Top 20 ranked cellular targets of miR-US25-1(Table 1). VHID00005674 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA CCNE2(cyclin E2) http://www.ncbi.nlm.nih.gov/gene/9134 Downregulation Luciferase assay, Western blot analysis, RISC-IP analysis, miRNA expression cassettes, Sequence analysis, miR-US25-1 KO virus, RT-PCR analysis. 20585629 Here, we show the virus also induces expression of cyclin E2 early in infection, then moderates cyclin E2 protein levels through targeting by miR-US25-1.To confirm that enrichment of identified transcripts was due to binding of miR-US25-1 to the 5'UTR, the 5'UTRs and ~500 bases of upstream genomic sequence of two of the top target genes, cyclin E2 and H3F3B, were cloned in front of a luciferase reporter construct. VHID00005675 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA CD147 http://www.ncbi.nlm.nih.gov/gene/682 Downregulation Luciferase assay, Western blot analysis, miRNA expression cassettes, Sequence analysis, miR-US25-1 KO virus, RT-PCR analysis, RNA induced silencing complex immunoprecipitation(RISC-IP) techniques. 20585629 Intriguingly,many of the genes targeted by miR-US25-1 are associated with cell cycle control, including cyclin E2, BRCC3, EID1, MAPRE2, and CD147, suggesting that miR-US25-1 is targeting genes within a related pathway. VHID00005676 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA DBN1 http://www.ncbi.nlm.nih.gov/gene/1627 - Luciferase assay. 20585629 Top 20 ranked cellular targets of miR-US25-1(Table 1). VHID00005677 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA EID1 http://www.ncbi.nlm.nih.gov/gene/23741 Downregulation Luciferase assay, Western blot analysis, miRNA expression cassettes, Sequence analysis, miR-US25-1 KO virus, RT-PCR analysis, RNA induced silencing complex immunoprecipitation(RISC-IP) techniques. 20585629 Intriguingly,many of the genes targeted by miR-US25-1 are associated with cell cycle control, including cyclin E2, BRCC3, EID1, MAPRE2, and CD147, suggesting that miR-US25-1 is targeting genes within a related pathway. VHID00005678 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA H3F3B http://www.ncbi.nlm.nih.gov/gene/3021 - Luciferase assay, Western blot analysis, miRNA expression cassettes, Sequence analysis, miR-US25-1 KO virus, RT-PCR analysis, RNA induced silencing complex immunoprecipitation(RISC-IP) techniques. 20585629 To confirm that enrichment of identified transcripts was due to binding of miR-US25-1 to the 5'UTR, the 5'UTRs and k500 bases of upstream genomic sequence of two of the top target genes, cyclin E2 and H3F3B, were cloned in front of a luciferase reporter construct. VHID00005679 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA LOC440093 # - Luciferase assay. 20585629 Top 20 ranked cellular targets of miR-US25-1(Table 1). VHID00005680 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA MAPRE2 http://www.ncbi.nlm.nih.gov/gene/10982 Downregulation Luciferase assay, Western blot analysis, miRNA expression cassettes, Sequence analysis, miR-US25-1 KO virus, RT-PCR analysis, RNA induced silencing complex immunoprecipitation(RISC-IP) techniques. 20585629 Intriguingly,many of the genes targeted by miR-US25-1 are associated with cell cycle control, including cyclin E2, BRCC3, EID1, MAPRE2, and CD147, suggesting that miR-US25-1 is targeting genes within a related pathway. VHID00005681 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA NUCB2 http://www.ncbi.nlm.nih.gov/gene/4925 - Luciferase assay. 20585629 Top 20 ranked cellular targets of miR-US25-1(Table 1). VHID00005682 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA POP4 http://www.ncbi.nlm.nih.gov/gene/10775 - Luciferase assay. 20585629 Top 20 ranked cellular targets of miR-US25-1(Table 1). VHID00005683 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA PSMA4 http://www.ncbi.nlm.nih.gov/gene/5685 - Luciferase assay. 20585629 Top 20 ranked cellular targets of miR-US25-1(Table 1). VHID00005684 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA SGK1(SGK) http://www.ncbi.nlm.nih.gov/gene/6446 - Luciferase assay. 20585629 Top 20 ranked cellular targets of miR-US25-1(Table 1). VHID00005685 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA SGSH http://www.ncbi.nlm.nih.gov/gene/6448 - Luciferase assay. 20585629 Top 20 ranked cellular targets of miR-US25-1(Table 1). VHID00005686 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US25-1(miR-US25-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001684 - - Host mRNA TRIM28 http://www.ncbi.nlm.nih.gov/gene/10155 Downregulation Luciferase assays, Western blot analysis, RISC-IP analysis, miRNA expression cassettes, Sequence analysis, miR-US25-1 KO virus, RT-PCR analysis. 20585629 The effects of virally expressed miR-US25-1 on two top targets, cyclin E2 and TRIM28, were determined by western blot analysis. gure 5d also shows a clear increase in expression of cyclin E2, and to a lesser extent TRIM28, in cells infected with the miR-US25-1 knock-out virus compared to wild type infected cells, demonstrating that miR-US25-1 reduces the expression of these target genes. VHID00005687 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US4(miR-US4-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003687 CD8+ T cell - Host mRNA ERAP1 http://www.ncbi.nlm.nih.gov/gene/51752 Downregulation PCR. 22568714 Table2. Human CMV miRNAs and their functions. Inhibits HCMV IE1 gene expression, and acts as an immune response inhibitor to help viral replication.Inhibits HCMV IE1gene expression, and acts as an immune response inhibitor to help viral replication Specifically downregulates MICB expression during viral infection, leading to decreased binding of NKG2D and reduced killing by NK cells. VHID00005688 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US4(miR-US4-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003687 HCMV-specific cytotoxic T lymphocytes - Host Protein ERAP1 http://www.ncbi.nlm.nih.gov/gene/51752 Downregulation QRT-PCR, Luciferase assay, Immunoblotting, and RNase protection assay, RNA blotting. 21892175 We show here that HCMV miR-US4-1 specifically downregulated ERAP1 expression during viral infection.Accordingly, the trimming of HCMV-derived peptides is inhibited, leading to reduced susceptibility of infected cells to HCMV-specific cytotoxic T lymphocytes(CTLs).. VHID00005689 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-miR-H1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006106 CD4+ T lymphocytes cells - Host mRNA AATF http://www.ncbi.nlm.nih.gov/gene/26574 Downregulation Predicted. 22936931 Table 1 includes the RNAi pathway related gene products that are targeted by HIV-1 microRNAs. List of published HIV-1 microRNAs and their target HIV-1 and cellular gene products.The target interactions of HIV-1 microRNAs with its mRNA seem to function as viral genome regulators. VHID00005690 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-miR-H1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006106 CD4+ T lymphocytes cells - Host mRNA BCL2 http://www.ncbi.nlm.nih.gov/gene/596 Downregulation Predicted. 22936931 Table 1 includes the RNAi pathway related gene products that are targeted by HIV-1 microRNAs. List of published HIV-1 microRNAs and their target HIV-1 and cellular gene products.The target interactions of HIV-1 microRNAs with its mRNA seem to function as viral genome regulators. VHID00005691 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-miR-H1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006106 CD4+ T lymphocytes cells - Host mRNA DICER1(DICER) http://www.ncbi.nlm.nih.gov/gene/23405 Downregulation Predicted. 22936931 Table 1 includes the RNAi pathway related gene products that are targeted by HIV-1 microRNAs. List of published HIV-1 microRNAs and their target HIV-1 and cellular gene products.The target interactions of HIV-1 microRNAs with its mRNA seem to function as viral genome regulators. VHID00005692 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-miR-H1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006106 CD4+ T lymphocytes cells - Host mRNA MYC http://www.ncbi.nlm.nih.gov/gene/4609 Downregulation Predicted. 22936931 Table 1 includes the RNAi pathway related gene products that are targeted by HIV-1 microRNAs. List of published HIV-1 microRNAs and their target HIV-1 and cellular gene products.The target interactions of HIV-1 microRNAs with its mRNA seem to function as viral genome regulators. VHID00005693 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-miR-H1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006106 CD4+ T lymphocytes cells - Host mRNA PAWR http://www.ncbi.nlm.nih.gov/gene/5074 Downregulation Predicted. 22936931 Table 1 includes the RNAi pathway related gene products that are targeted by HIV-1 microRNAs. List of published HIV-1 microRNAs and their target HIV-1 and cellular gene products.The target interactions of HIV-1 microRNAs with its mRNA seem to function as viral genome regulators. VHID00005694 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-miR-H1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006106 CD4+ T lymphocytes cells - Host miRNA hsa-miR-194(hsa-miR-194) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000488 Downregulation Predicted. 22936931 Table 1 includes the RNAi pathway related gene products that are targeted by HIV-1 microRNAs. List of published HIV-1 microRNAs and their target HIV-1 and cellular gene products.The target interactions of HIV-1 microRNAs with its mRNA seem to function as viral genome regulators. VHID00005695 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-miR-H1(miR-H1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006106 - - Host Protein AATF http://www.ncbi.nlm.nih.gov/gene/26574 Downregulation Luciferase reporter, immunofluorescence, RT-PCR. 21133815 MiR-H1 has been demonstrated to degrade the apoptosis antagonizing transcription factor(AATF) gene product. Downregulation of AATF is accompanied by lowered cell viability and lowered Bcl-2, c-myc, Par-4 and Dicer levels. VHID00005696 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-miR-H1(miR-H1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006106 - - Host miRNA hsa-mir-149(miR149) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000478 Downregulation Luciferase reporter, immunofluorescence, RT-PCR. 21133815 It was also noted further that HIV miR-H1 downregulated expression of the cellular miRNA miR149, which is considered to target the Vpr gene encoded by HIV-1. VHID00005697 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-miR-TAR-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006016 CD4+ T lymphocytes cells - Host mRNA ERCC1 http://www.ncbi.nlm.nih.gov/gene/2067 Downregulation Luciferase assay. 22936931 Table 1 includes the RNAi pathway related gene products that are targeted by HIV-1 microRNAs. List of published HIV-1 microRNAs and their target HIV-1 and cellular gene products.The target interactions of HIV-1 microRNAs with its mRNA seem to function as viral genome regulators. VHID00005698 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-miR-TAR-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006016 CD4+ T lymphocytes cells - Host mRNA IER3 http://www.ncbi.nlm.nih.gov/gene/8870 Downregulation Luciferase assay. 22936931 Table 1 includes the RNAi pathway related gene products that are targeted by HIV-1 microRNAs. List of published HIV-1 microRNAs and their target HIV-1 and cellular gene products.The target interactions of HIV-1 microRNAs with its mRNA seem to function as viral genome regulators. VHID00005699 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-H1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006106 Human blood mononuclear cells - Host Protein AATF http://www.ncbi.nlm.nih.gov/gene/26574 Downregulation FACS analysis, trypan-blue dye exclusion method, microarray analysis, Real-Time PCR, Bioinformatic analysis. 19082544 There cent discovery of HIV-1 genome-encoded novel microRNA(miRNA; designated as hiv1-mir-H1) having ability to target selectively and specifically human cellular AATF gene. VHID00005700 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-H1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006106 Human blood mononuclear cells - Host Protein BCL2 http://www.ncbi.nlm.nih.gov/gene/596 Downregulation FACS analysis, trypan-blue dye exclusion method, microarray analysis, Real-Time PCR, Bioinformatic analysis. 19082544 There cent discovery of HIV-1 genome-encoded novel microRNA(miRNA; designated as hiv1-mir-H1) having ability to target selectively and specifically human cellular AATF gene, prompted us to explore the role of this miRNA in the regulation of genes involved in cellular apoptosis, proliferation and nucleic acid-based immune mechanism governed by miRNAs. Such a study revealed that this miRNA-induced knockdown of AATF gene, within normal human blood mononuclear cells, was responsible for the suppression of genes coding for Bcl-2, c-myc, Par-4 and Dicer. VHID00005701 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-H1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006106 Human blood mononuclear cells - Host Protein DICER http://www.ncbi.nlm.nih.gov/gene/23405 Downregulation FACS analysis, trypan-blue dye exclusion method, microarray analysis, Real-Time PCR, Bioinformatic analysis. 19082544 There cent discovery of HIV-1 genome-encoded novel microRNA(miRNA; designated as hiv1-mir-H1) having ability to target selectively and specifically human cellular AATF gene, prompted us to explore the role of this miRNA in the regulation of genes involved in cellular apoptosis, proliferation and nucleic acid-based immune mechanism governed by miRNAs. Such a study revealed that this miRNA-induced knockdown of AATF gene, within normal human blood mononuclear cells, was responsible for the suppression of genes coding for Bcl-2, c-myc, Par-4 and Dicer. VHID00005702 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-H1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006106 Human blood mononuclear cells - Host Protein MYC( c-Myc) http://www.ncbi.nlm.nih.gov/gene/4609 Downregulation FACS analysis, trypan-blue dye exclusion method, microarray analysis, Real-Time PCR, Bioinformatic analysis. 19082544 There cent discovery of HIV-1 genome-encoded novel microRNA(miRNA; designated as hiv1-mir-H1) having ability to target selectively and specifically human cellular AATF gene, prompted us to explore the role of this miRNA in the regulation of genes involved in cellular apoptosis, proliferation and nucleic acid-based immune mechanism governed by miRNAs. Such a study revealed that this miRNA-induced knockdown of AATF gene, within normal human blood mononuclear cells, was responsible for the suppression of genes coding for Bcl-2, c-myc, Par-4 and Dicer. VHID00005703 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-H1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006106 Human blood mononuclear cells - Host Protein PAWR(Par-4) http://www.ncbi.nlm.nih.gov/gene/5074 Downregulation FACS analysis, trypan-blue dye exclusion method, microarray analysis, Real-Time PCR, Bioinformatic analysis. 19082544 Such a study revealed that this miRNA-induced knockdown of AATF gene, within normal human blood mononuclear cells, was responsible for the suppression of genes coding for Bcl-2, c-myc, Par-4 and Dicer. VHID00005704 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-H1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006106 Human blood mononuclear cells - Host miRNA hsa-mir-149(miR149) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000478 Downregulation FACS analysis, trypan-blue dye exclusion method, microarray analysis, Real-Time PCR, Bioinformatic analysis. 19082544 Hiv1-mir-H1 had the capacity to downregulate expression of cellular miR149 gene recognized to target Vpr gene encoded by HIV-2. VHID00005705 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR(TAR) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 293T cells - Host Protein DICER1(Dicer) http://www.ncbi.nlm.nih.gov/gene/23405 Downregulation Luciferase reporter, immunofluorescence, RT-PCR. 21133815 It has also been demonstrated by ethidium bromide staining and radioactive labeling that the TAR--Dicer association results in cleavage of the TAR RNA. VHID00005706 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR(TAR) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 293T cells - Host Protein ERCC1 http://www.ncbi.nlm.nih.gov/gene/2067 Upregulation Luciferase reporter, immunofluorescence, RT-PCR. 21133815 Microarray analysis of RNA isolated from TAR transfected cells using an Affymetrix human focus array identified 18 human genes that were downregulated and 14 genes that were upregulated. Further validation of four of these genes showed possible links to apoptosis and cell survival including ERCC1 (excision repair cross complementing-group 1), PIASg (protein inhibitor of acti-vated STATg), GIT2 (GPCR interacting protein) and IER3 (intermediate early response 3). VHID00005707 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR(TAR) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 293T cells - Host Protein GIT2 http://www.ncbi.nlm.nih.gov/gene/9815 Upregulation Luciferase reporter, immunofluorescence, RT-PCR. 21133815 Microarray analysis of RNA isolated from TAR transfected cells using an Affymetrix human focus array identified 18 human genes that were downregulated and 14 genes that were upregulated. Further validation of four of these genes showed possible links to apoptosis and cell survival including ERCC1 (excision repair cross complementing-group 1), PIASg (protein inhibitor of acti-vated STATg), GIT2 (GPCR interacting protein) and IER3 (intermediate early response 3). VHID00005708 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR(TAR) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 293T cells - Host Protein HDAC1 http://www.ncbi.nlm.nih.gov/gene/3065 Downregulation Luciferase reporter, immunofluorescence, RT-PCR. 21133815 This recruitment of HDAC-1 to the HIV-1 LTR by the TAR element suggested that the TAR element is capable of transcriptional silencing via the RITS mechanism.The article provides insights into TAR miRNA-mediated downregulation of viral and host gene expression by recruitment of chromatin remodeling components(HDAC1). VHID00005709 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR(TAR) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 293T cells - Host Protein IER3 http://www.ncbi.nlm.nih.gov/gene/8870 Upregulation Luciferase reporter, immunofluorescence, RT-PCR. 21133815 Microarray analysis of RNA isolated from TAR transfected cells using an Affymetrix human focus array identified 18 human genes that were downregulated and 14 genes that were upregulated. Further validation of four of these genes showed possible links to apoptosis and cell survival including ERCC1 (excision repair cross complementing-group 1), PIASg (protein inhibitor of acti-vated STATg), GIT2 (GPCR interacting protein) and IER3 (intermediate early response 3). VHID00005710 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR(TAR) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 293T cells - Host Protein PIAS4(PIASg) http://www.ncbi.nlm.nih.gov/gene/51588 Upregulation Luciferase reporter, immunofluorescence, RT-PCR. 21133815 Microarray analysis of RNA isolated from TAR transfected cells using an Affymetrix human focus array identified 18 human genes that were downregulated and 14 genes that were upregulated. Further validation of four of these genes showed possible links to apoptosis and cell survival including ERCC1 (excision repair cross complementing-group 1), PIASg (protein inhibitor of acti-vated STATg), GIT2 (GPCR interacting protein) and IER3 (intermediate early response 3). VHID00005711 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR(hiv1-miR-TAR-5p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 CD4+ T lymphocytes - Host mRNA ERCC1 http://www.ncbi.nlm.nih.gov/gene/2067 Downregulation Western blots, RT-PCR, Affymetrix MicroArray analysis. 19220914 Specifically, the microRNA down-regulates ERCC1 and IER3, protecting the cell from apoptosis. Comparison to our cloned sequence reveals possible target sites for the TAR miRNA as well. VHID00005712 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR(hiv1-miR-TAR-5p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 CD4+ T lymphocytes - Host mRNA IER3 http://www.ncbi.nlm.nih.gov/gene/8870 Downregulation Western blots, RT-PCR, Affymetrix MicroArray analysis. 19220914 Specifically, the microRNA down-regulates ERCC1 and IER3, protecting the cell from apoptosis. Comparison to our cloned sequence reveals possible target sites for the TAR miRNA as well. VHID00005713 Human immunodeficiency virus 1(HIV-1) Mus musculus Virus miRNA hiv1-miR-N367(miR-N367) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006104 Jurkat T cells - Host Protein Tnip1(nef) http://www.ncbi.nlm.nih.gov/gene/57783 Downregulation Luciferase reporter, immunofluorescence, RT-PCR. 21133815 Using EGFP and luciferase reporter constructs downstream of the nef target, nef miRNAs have been shown to downregulate nef expression in Jurkat T cells.Impressively,the nef miRNA (miR-N367) was effectively able to downregulate nef expression in the subcapsular regions of the spleen in mice, as determined by immunofluorescence and RT-PCR assays. VHID00005714 Human immunodeficiency virus 1(HIV-1) Mus musculus Virus miRNA nef # MT-4 T cells - Host Protein Pparg(PPAR-gamma) http://www.ncbi.nlm.nih.gov/gene/19016 Downregulation Luciferase reporter, immunofluorescence, RT-PCR. 21133815 One of the downstream targets of nef is PPAR-gamma and nef suppresses PPAR-gamma expression. In mice expressing nef miRNA, significant suppression of PPAR-gamma expression was seen in the intestinal adipose tissue. VHID00005715 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus LncRNA PAN # - - Host Protein PABPC1 http://www.ncbi.nlm.nih.gov/gene/26986 Downregulation Western blot,Immunoprecipitation(IP),CLIP. 23077296 During KSHV lytic infection, the expression of viral ORF57 leads to a substantial decrease in overall PABPC1 expression, along with a shift in the cellular distribution of the remaining PABPC1 to the nucleus. Together, these data indicate that PABPC1 is an important cellular target of viral ORF57 to directly upregulate PAN accumulation during viral lytic infection, and the ability of host PABPC1 to disrupt ORF57 expression is a strategic host counterbalancing mechanism. VHID00005716 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus LncRNA PAN # 293L cells - Host Protein KDM6A(UTX) http://www.ncbi.nlm.nih.gov/gene/7403 Downregulation Chromatin Immunoprecipitation (ChIP), Real-time PCR, RNA Cross-Linking Immunoprecipitation (RNA CLIP), Chromatin Isolation by RNA Purification (ChIRP), RNA chromatin immunoprecipitation assays, Southern blot analysis. 22589717 To investigate the role of PAN RNA in the activation of K-Rta expression, we demonstrate that PAN RNA physically interacts with the ORF50 promoter. RNA chromatin immunoprecipitation assays show that PAN RNA interacts with demethylases JMJD3 and UTX, and the histone methyltransferase MLL2. Consistent with the interaction with demethylases, expression of PAN RNA results in a decrease of the repressive H3K27me3 mark at the ORF50 promoter. VHID00005717 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus LncRNA PAN # 293L cells - Host Protein KDM6B(JMJD3) http://www.ncbi.nlm.nih.gov/gene/23135 Downregulation Chromatin Immunoprecipitation (ChIP), Real-time PCR, RNA Cross-Linking Immunoprecipitation (RNA CLIP), Chromatin Isolation by RNA Purification (ChIRP), RNA chromatin immunoprecipitation assays, Southern blot analysis. 22589717 To investigate the role of PAN RNA in the activation of K-Rta expression, we demonstrate that PAN RNA physically interacts with the ORF50 promoter. RNA chromatin immunoprecipitation assays show that PAN RNA interacts with demethylases JMJD3 and UTX, and the histone methyltransferase MLL2. Consistent with the interaction with demethylases, expression of PAN RNA results in a decrease of the repressive H3K27me3 mark at the ORF50 promoter. VHID00005718 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus LncRNA PAN # 293L cells - Host Protein KMT2B(MLL2) http://www.ncbi.nlm.nih.gov/gene/9757 Downregulation Chromatin Immunoprecipitation (ChIP), Real-time PCR, RNA Cross-Linking Immunoprecipitation (RNA CLIP), Chromatin Isolation by RNA Purification (ChIRP), RNA chromatin immunoprecipitation assays, Southern blot analysis. 22589717 To investigate the role of PAN RNA in the activation of K-Rta expression, we demonstrate that PAN RNA physically interacts with the ORF50 promoter. RNA chromatin immunoprecipitation assays show that PAN RNA interacts with demethylases JMJD3 and UTX, and the histone methyltransferase MLL2. Consistent with the interaction with demethylases, expression of PAN RNA results in a decrease of the repressive H3K27me3 mark at the ORF50 promoter. VHID00005719 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus LncRNA PAN # HEK293 cell lines Upregulation Host Protein PABPC1 http://www.ncbi.nlm.nih.gov/gene/26986 - Luciferase assays,Immunoprecipitation,CLIP. 23077296 We report that PABPC1 forms a complex with the Kaposi's sarcoma-associated herpesvirus(KSHV) ORF57 protein, which allows ORF57 to interact with a 9-nucleotide(nt) core element of KSHV polyadenylated nuclear(PAN) RNA, a viral long noncoding RNA(LncRNA), and increase PAN stability. These data indicate that PABPC1 is an important cellular target of viral ORF57 to directly upregulate PAN accumulation during viral lytic infection, and the ability of host PABPC1 to disrupt ORF57 expression is a strategic host counterbalancing mechanism. VHID00005720 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA ANKRD52 http://www.ncbi.nlm.nih.gov/gene/283373 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005721 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA ARRDC3 http://www.ncbi.nlm.nih.gov/gene/57561 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005722 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA C1orf55 http://www.ncbi.nlm.nih.gov/gene/163859 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005723 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA C20orf11 http://www.ncbi.nlm.nih.gov/gene/54994 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005724 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA C21orf91 http://www.ncbi.nlm.nih.gov/gene/54149 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005725 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA C2orf72 http://www.ncbi.nlm.nih.gov/gene/257407 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005726 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA CCND2 http://www.ncbi.nlm.nih.gov/gene/894 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005727 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA CCNL2 http://www.ncbi.nlm.nih.gov/gene/1235 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005728 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA CDV3 http://www.ncbi.nlm.nih.gov/gene/55573 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005729 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA CPEB3 http://www.ncbi.nlm.nih.gov/gene/22849 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005730 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA CREB1 http://www.ncbi.nlm.nih.gov/gene/1385 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005731 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA DBT http://www.ncbi.nlm.nih.gov/gene/1629 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005732 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA DENND1B http://www.ncbi.nlm.nih.gov/gene/163486 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005733 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA EDEM3 http://www.ncbi.nlm.nih.gov/gene/80267 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005734 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA FAM102B http://www.ncbi.nlm.nih.gov/gene/284611 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005735 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA FAM116A http://www.ncbi.nlm.nih.gov/gene/201627 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005736 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA FZD5 http://www.ncbi.nlm.nih.gov/gene/7855 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005737 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA HMGCR http://www.ncbi.nlm.nih.gov/gene/3156 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005738 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA KLHL8 http://www.ncbi.nlm.nih.gov/gene/57563 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005739 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA LARP4 http://www.ncbi.nlm.nih.gov/gene/113251 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005740 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA LMNB1 http://www.ncbi.nlm.nih.gov/gene/4001 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005741 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA MAGEB1 http://www.ncbi.nlm.nih.gov/gene/4112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005742 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA MCL1 http://www.ncbi.nlm.nih.gov/gene/4170 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005743 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA MTHFD2 http://www.ncbi.nlm.nih.gov/gene/10797 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005744 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA NFAT5 http://www.ncbi.nlm.nih.gov/gene/10725 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005745 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA NFIA http://www.ncbi.nlm.nih.gov/gene/4774 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005746 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA OIP5 http://www.ncbi.nlm.nih.gov/gene/11339 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005747 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA PDHX http://www.ncbi.nlm.nih.gov/gene/8050 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005748 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA PHACTR4 http://www.ncbi.nlm.nih.gov/gene/65979 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005749 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA PPM1D http://www.ncbi.nlm.nih.gov/gene/8493 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005750 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA QKI http://www.ncbi.nlm.nih.gov/gene/9444 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005751 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA RIMS3 http://www.ncbi.nlm.nih.gov/gene/9783 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005752 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA RNASEL http://www.ncbi.nlm.nih.gov/gene/6041 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005753 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA SESN1 http://www.ncbi.nlm.nih.gov/gene/27244 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005754 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA SETD5 http://www.ncbi.nlm.nih.gov/gene/55209 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005755 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA SLC35B2 http://www.ncbi.nlm.nih.gov/gene/347734 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005756 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA TMEM25 http://www.ncbi.nlm.nih.gov/gene/84866 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005757 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA TNRC18B http://www.ncbi.nlm.nih.gov/gene/27320 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005758 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA TRAM2 http://www.ncbi.nlm.nih.gov/gene/9697 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005759 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA TSC22D3 http://www.ncbi.nlm.nih.gov/gene/23151 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005760 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA UNC84A http://www.ncbi.nlm.nih.gov/gene/23353 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005761 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA WDFY1 http://www.ncbi.nlm.nih.gov/gene/57590 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005762 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA ZNF517 http://www.ncbi.nlm.nih.gov/gene/340385 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005763 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-1 - Host mRNA ZNF701 http://www.ncbi.nlm.nih.gov/gene/55762 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005764 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-3 - Host mRNA C2orf72 http://www.ncbi.nlm.nih.gov/gene/257407 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005765 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-3 - Host mRNA CCND2 http://www.ncbi.nlm.nih.gov/gene/894 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005766 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-3 - Host mRNA CDC37L1 http://www.ncbi.nlm.nih.gov/gene/55664 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005767 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-3 - Host mRNA CDV3 http://www.ncbi.nlm.nih.gov/gene/55573 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005768 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-3 - Host mRNA CUX1 http://www.ncbi.nlm.nih.gov/gene/1523 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005769 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-3 - Host mRNA FAM116A http://www.ncbi.nlm.nih.gov/gene/201627 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005770 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-3 - Host mRNA HMGCR http://www.ncbi.nlm.nih.gov/gene/3156 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005771 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-3 - Host mRNA KLHL8 http://www.ncbi.nlm.nih.gov/gene/57563 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005772 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-3 - Host mRNA LMNB1 http://www.ncbi.nlm.nih.gov/gene/4001 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005773 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-3 - Host mRNA MAGEB1 http://www.ncbi.nlm.nih.gov/gene/4112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005774 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-3 - Host mRNA MCL1 http://www.ncbi.nlm.nih.gov/gene/4170 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005775 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-3 - Host mRNA MTHFD2 http://www.ncbi.nlm.nih.gov/gene/10797 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005776 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-3 - Host mRNA OIP5 http://www.ncbi.nlm.nih.gov/gene/11339 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005777 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-3 - Host mRNA PDHX http://www.ncbi.nlm.nih.gov/gene/8050 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005778 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 - - Host Protein CDKN1A(cyclin-dependent kinase inhibitor p21) http://www.ncbi.nlm.nih.gov/gene/1026 - Cell cycle experiments, Western blotting and qRT-PCR, Indicator assays and primer extensions, Cell culture and generation of viral transductants, qPCR analysis of KSHV genome content. 20219912 Here, we report that cellular mRNAs encoding the cellular cyclin-dependent kinase inhibitor p21, a key inducer of cell cycle arrest, are direct targets for KSHV miR-K1. Ectopically expressed KSHV miR-K1 specifically inhibited the expression of endogenous p21 in KSHV-negative cells and strongly attenuated the cell cycle arrest that normally occurs upon p53 activation. VHID00005779 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 - - Host Protein IkappaBalpha http://www.ncbi.nlm.nih.gov/gene/4790 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00005780 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-3 - Host mRNA RNASEL http://www.ncbi.nlm.nih.gov/gene/6041 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005781 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-3 - Host mRNA SNX11 http://www.ncbi.nlm.nih.gov/gene/29916 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005782 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-1-3p(miR-K1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015214 BC-3 - Host mRNA ZNF517 http://www.ncbi.nlm.nih.gov/gene/340385 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005783 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a(miR-K10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BJAB and BCBL-3 cells - Host Protein BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 Downregulation Immunoblotting and apoptosis, Luciferase assays, Sequence Analysis, Microarray data, miRNA expression. 19098914 The functional consequence of this downregulation for KSHV latency can be assessed by examining the effects of BCLAF1 modulation on viral replication. When latently infected cells are chemically induced to lytic KSHV growth, antagonism of miRs K5,9, 10a and 10b is associated with decreased virion production (Fig. 5a) and increased BCLAF1 expression (Fig. 5c). This suggests that BCLAF1 action acts to impair lytic viral replication. VHID00005784 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a(miR-K10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 Primary effusion lymphoma (PEL) cell lines - Host Protein BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 - 3'UTR indicator assays ,RIP-CHIP. 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00005785 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 - - Host Protein TNFRSF12A http://www.ncbi.nlm.nih.gov/gene/51330 Downregulation Luciferase assays, Quantitative RT-PCR assays for cytokine expression, Western blot analysis, Statistical analysis, Caspase activation assay. 20844036 TWEAKR was one of the top predicted targets for KSHV miR-K12-10a (miR-K10a) based on expression changes. In this report, we validate TWEAKR as a target of miR-K10a.TWEAKR (also known as Fn14, TNFRSF12A, or CD266).The expression of TWEAKR was downregulated in cells transfected with miR-K10a as well as during de novo KSHV infection. VHID00005786 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA AADACL1 http://www.ncbi.nlm.nih.gov/gene/57552 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005787 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA C10orf18 http://www.ncbi.nlm.nih.gov/gene/54906 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005788 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA CBX6 http://www.ncbi.nlm.nih.gov/gene/23466 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005789 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA CLUAP1 http://www.ncbi.nlm.nih.gov/gene/23059 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005790 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA DNAJC16 http://www.ncbi.nlm.nih.gov/gene/23341 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005791 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA EARS2 http://www.ncbi.nlm.nih.gov/gene/124454 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005792 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA EXOC1 http://www.ncbi.nlm.nih.gov/gene/55763 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005793 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA FOXJ3 http://www.ncbi.nlm.nih.gov/gene/22887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005794 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA FOXK2 http://www.ncbi.nlm.nih.gov/gene/3607 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005795 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA FTO http://www.ncbi.nlm.nih.gov/gene/79068 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005796 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA GIT2 http://www.ncbi.nlm.nih.gov/gene/9815 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005797 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA IRF9 http://www.ncbi.nlm.nih.gov/gene/10379 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005798 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA ITPR3 http://www.ncbi.nlm.nih.gov/gene/3710 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005799 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA LASS6 http://www.ncbi.nlm.nih.gov/gene/253782 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005800 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA MAML2 http://www.ncbi.nlm.nih.gov/gene/84441 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005801 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA MAP2K4 http://www.ncbi.nlm.nih.gov/gene/6416 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005802 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA MKNK2 http://www.ncbi.nlm.nih.gov/gene/2872 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005803 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA MLL2 http://www.ncbi.nlm.nih.gov/gene/8085 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005804 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA PHC3 http://www.ncbi.nlm.nih.gov/gene/80012 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005805 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA PLS3 http://www.ncbi.nlm.nih.gov/gene/5358 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005806 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA POMP http://www.ncbi.nlm.nih.gov/gene/51371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005807 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA PTAR1 http://www.ncbi.nlm.nih.gov/gene/375743 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005808 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA SERPINB9 http://www.ncbi.nlm.nih.gov/gene/5272 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005809 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA SETD5 http://www.ncbi.nlm.nih.gov/gene/55209 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005810 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA SIK2 http://www.ncbi.nlm.nih.gov/gene/23235 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005811 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA SLTM http://www.ncbi.nlm.nih.gov/gene/79811 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005812 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA TFIP11 http://www.ncbi.nlm.nih.gov/gene/24144 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005813 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA TNFSF9 http://www.ncbi.nlm.nih.gov/gene/8744 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005814 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA UBN2 http://www.ncbi.nlm.nih.gov/gene/254048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005815 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA ULK1 http://www.ncbi.nlm.nih.gov/gene/8408 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005816 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA UNK http://www.ncbi.nlm.nih.gov/gene/85451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005817 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA WAC http://www.ncbi.nlm.nih.gov/gene/51322 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005818 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA WDR82 http://www.ncbi.nlm.nih.gov/gene/80335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005819 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA ZNF142 http://www.ncbi.nlm.nih.gov/gene/7701 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005820 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA ZNF275 http://www.ncbi.nlm.nih.gov/gene/10838 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005821 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10a-5p(miR-K10a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015212 BC-3 - Host mRNA ZNF330 http://www.ncbi.nlm.nih.gov/gene/27309 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005822 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10b(miR-K10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BJAB and BCBL-3 cells - Host Protein BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 Downregulation Immunoblotting and apoptosis, Luciferase assays, Sequence Analysis, Microarray data, miRNA expression. 19098914 The functional consequence of this downregulation for KSHV latency can be assessed by examining the effects of BCLAF1 modulation on viral replication. When latently infected cells are chemically induced to lytic KSHV growth, antagonism of miRs K5,9, 10a and 10b is associated with decreased virion production (Fig. 5a) and increased BCLAF1 expression (Fig. 5c). This suggests that BCLAF1 action acts to impair lytic viral replication. VHID00005823 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10b(miR-K10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 Primary effusion lymphoma (PEL) cell lines - Host Protein BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 - 3'UTR indicator assays ,RIP-CHIP. 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00005824 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 - - Host Protein BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00005825 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 Primary effusion lymphoma (PEL) cell lines - Host Protein AGTRAP http://www.ncbi.nlm.nih.gov/gene/57085 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00005826 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 Primary effusion lymphoma (PEL) cell lines - Host Protein BACH1 http://www.ncbi.nlm.nih.gov/gene/571 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00005827 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 Primary effusion lymphoma (PEL) cell lines - Host Protein IKBKE http://www.ncbi.nlm.nih.gov/gene/9641 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00005828 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 Primary effusion lymphoma (PEL) cell lines - Host Protein PIK3CA http://www.ncbi.nlm.nih.gov/gene/5290 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00005829 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 Primary effusion lymphoma (PEL) cell lines - Host Protein RFK http://www.ncbi.nlm.nih.gov/gene/55312 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00005830 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 Primary effusion lymphoma (PEL) cell lines - Host Protein RPS6KA3 http://www.ncbi.nlm.nih.gov/gene/6197 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00005831 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 Primary effusion lymphoma (PEL) cell lines - Host Protein SAMHD1 http://www.ncbi.nlm.nih.gov/gene/25939 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00005832 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 Primary effusion lymphoma (PEL) cell lines - Host Protein SLA http://www.ncbi.nlm.nih.gov/gene/6503 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00005833 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 Primary effusion lymphoma (PEL) cell lines - Host Protein TWF1 http://www.ncbi.nlm.nih.gov/gene/5756 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00005834 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 Primary effusion lymphoma (PEL) cell lines - Host Protein XAF1 http://www.ncbi.nlm.nih.gov/gene/54739 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00005835 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 B-cell - Host mRNA BRIP1(BACH-1) http://www.ncbi.nlm.nih.gov/gene/83990 Downregulation Luciferase assays,Northern blot analysis,Microarray. 17881434 Bioinformatic tools predicted the transcriptional repressor BACH-1 to be targeted by both miRNAs, and ectopic expression of either miR-155 or miR-K12-11 inhibited a BACH-1 3'UTR-containing reporter. Furthermore, BACH-1 protein levels are low in cells expressing either miRNA. VHID00005836 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA AKT1 http://www.ncbi.nlm.nih.gov/gene/207 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005837 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA APOLD1 http://www.ncbi.nlm.nih.gov/gene/81575 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005838 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA ARPC4 http://www.ncbi.nlm.nih.gov/gene/26140 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005839 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA BCORL1 http://www.ncbi.nlm.nih.gov/gene/63035 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005840 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA BECN1 http://www.ncbi.nlm.nih.gov/gene/8678 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005841 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA BSN http://www.ncbi.nlm.nih.gov/gene/8927 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005842 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA C12orf4 http://www.ncbi.nlm.nih.gov/gene/283461 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005843 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA C1orf128 http://www.ncbi.nlm.nih.gov/gene/57095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005844 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA C6orf120 http://www.ncbi.nlm.nih.gov/gene/387263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005845 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA C8orf38 http://www.ncbi.nlm.nih.gov/gene/137682 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005846 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA CAMSAP1L1 http://www.ncbi.nlm.nih.gov/gene/23271 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005847 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA CBX3 http://www.ncbi.nlm.nih.gov/gene/11335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005848 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005849 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA CD48 http://www.ncbi.nlm.nih.gov/gene/962 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005850 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA CRY2 http://www.ncbi.nlm.nih.gov/gene/1408 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005851 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA CSTF2 http://www.ncbi.nlm.nih.gov/gene/1478 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005852 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA DCBLD2 http://www.ncbi.nlm.nih.gov/gene/131566 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005853 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA DCP2 http://www.ncbi.nlm.nih.gov/gene/167227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005854 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA DGKE http://www.ncbi.nlm.nih.gov/gene/8526 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005855 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA EFHD2 http://www.ncbi.nlm.nih.gov/gene/79180 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005856 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA ETNK1 http://www.ncbi.nlm.nih.gov/gene/55500 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005857 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA EYA4 http://www.ncbi.nlm.nih.gov/gene/2070 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005858 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA FAM126B http://www.ncbi.nlm.nih.gov/gene/285172 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005859 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA FAM49B http://www.ncbi.nlm.nih.gov/gene/51571 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005860 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA FBXO3 http://www.ncbi.nlm.nih.gov/gene/26273 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005861 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA FOXP2 http://www.ncbi.nlm.nih.gov/gene/93986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005862 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA GATAD1 http://www.ncbi.nlm.nih.gov/gene/57798 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005863 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA GBP3 http://www.ncbi.nlm.nih.gov/gene/2635 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005864 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA GLCCI1 http://www.ncbi.nlm.nih.gov/gene/113263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005865 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA GNB1 http://www.ncbi.nlm.nih.gov/gene/2782 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005866 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA GSPT1 http://www.ncbi.nlm.nih.gov/gene/2935 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005867 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA HECA http://www.ncbi.nlm.nih.gov/gene/51696 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005868 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA HMGXB4 http://www.ncbi.nlm.nih.gov/gene/10042 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005869 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA HOXC6 http://www.ncbi.nlm.nih.gov/gene/3223 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005870 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA IKZF3 http://www.ncbi.nlm.nih.gov/gene/22806 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005871 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA IL2RB http://www.ncbi.nlm.nih.gov/gene/3560 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005872 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA JMY http://www.ncbi.nlm.nih.gov/gene/133746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005873 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA KIF2A http://www.ncbi.nlm.nih.gov/gene/3796 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005874 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA MBD2 http://www.ncbi.nlm.nih.gov/gene/8932 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005875 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA MCL1 http://www.ncbi.nlm.nih.gov/gene/4170 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005876 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA MED20 http://www.ncbi.nlm.nih.gov/gene/9477 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005877 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA MESDC2 http://www.ncbi.nlm.nih.gov/gene/23184 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005878 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA MTMR6 http://www.ncbi.nlm.nih.gov/gene/9107 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005879 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA MTPN http://www.ncbi.nlm.nih.gov/gene/767558 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005880 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA MYB http://www.ncbi.nlm.nih.gov/gene/4602 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005881 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA NHLRC2 http://www.ncbi.nlm.nih.gov/gene/374354 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005882 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA NLN http://www.ncbi.nlm.nih.gov/gene/57486 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005883 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA NUPL1 http://www.ncbi.nlm.nih.gov/gene/9818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005884 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA ODF2L http://www.ncbi.nlm.nih.gov/gene/57489 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005885 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA PDE7A http://www.ncbi.nlm.nih.gov/gene/5150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005886 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA PGAP1 http://www.ncbi.nlm.nih.gov/gene/80055 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005887 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA PI4KB http://www.ncbi.nlm.nih.gov/gene/5298 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005888 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA PLAG1 http://www.ncbi.nlm.nih.gov/gene/5324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005889 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA POLR1D http://www.ncbi.nlm.nih.gov/gene/51082 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005890 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA PPAP2B http://www.ncbi.nlm.nih.gov/gene/8613 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005891 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA PPP1CB http://www.ncbi.nlm.nih.gov/gene/245711 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005892 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA PPP1R2 http://www.ncbi.nlm.nih.gov/gene/5504 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005893 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA PPP4R2 http://www.ncbi.nlm.nih.gov/gene/151987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005894 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA PRICKLE4 http://www.ncbi.nlm.nih.gov/gene/29964 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005895 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA PRR3 http://www.ncbi.nlm.nih.gov/gene/80742 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005896 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA RAB2B http://www.ncbi.nlm.nih.gov/gene/84932 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005897 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA RAB3IP http://www.ncbi.nlm.nih.gov/gene/117177 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005898 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA RASSF8 http://www.ncbi.nlm.nih.gov/gene/11228 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005899 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA RFX7 http://www.ncbi.nlm.nih.gov/gene/64864 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005900 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA RGL2 http://www.ncbi.nlm.nih.gov/gene/5863 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005901 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA SAMD9L http://www.ncbi.nlm.nih.gov/gene/219285 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005902 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA SASS6 http://www.ncbi.nlm.nih.gov/gene/163786 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005903 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA SCRIB http://www.ncbi.nlm.nih.gov/gene/23513 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005904 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA SDHAF1 http://www.ncbi.nlm.nih.gov/gene/644096 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005905 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA SEC24A http://www.ncbi.nlm.nih.gov/gene/10802 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005906 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA SLC11A2 http://www.ncbi.nlm.nih.gov/gene/4891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005907 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA SLC35D1 http://www.ncbi.nlm.nih.gov/gene/23169 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005908 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA SLC35F5 http://www.ncbi.nlm.nih.gov/gene/80255 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005909 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA SNRNP27 http://www.ncbi.nlm.nih.gov/gene/11017 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005910 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA SNW1 http://www.ncbi.nlm.nih.gov/gene/22938 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005911 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA SPIN1 http://www.ncbi.nlm.nih.gov/gene/10927 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005912 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA SYT4 http://www.ncbi.nlm.nih.gov/gene/6860 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005913 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA TBL1XR1 http://www.ncbi.nlm.nih.gov/gene/79718 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005914 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA TCEB3 http://www.ncbi.nlm.nih.gov/gene/6924 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005915 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA TERF1 http://www.ncbi.nlm.nih.gov/gene/646316 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005916 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA TGS1 http://www.ncbi.nlm.nih.gov/gene/96764 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005917 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA THUMPD1 http://www.ncbi.nlm.nih.gov/gene/55623 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005918 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA TM9SF3 http://www.ncbi.nlm.nih.gov/gene/56889 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005919 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA TMEM30A http://www.ncbi.nlm.nih.gov/gene/55754 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005920 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA TNRC6A http://www.ncbi.nlm.nih.gov/gene/27327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005921 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA TPD52 http://www.ncbi.nlm.nih.gov/gene/7163 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005922 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA TRIM32 http://www.ncbi.nlm.nih.gov/gene/22954 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005923 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA USP31 http://www.ncbi.nlm.nih.gov/gene/57478 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005924 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA XPO5 http://www.ncbi.nlm.nih.gov/gene/57510 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005925 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA ZFP82 http://www.ncbi.nlm.nih.gov/gene/284406 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005926 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-1 - Host mRNA ZMAT3 http://www.ncbi.nlm.nih.gov/gene/64393 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005927 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA AP3D1 http://www.ncbi.nlm.nih.gov/gene/8943 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005928 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA ARL5B http://www.ncbi.nlm.nih.gov/gene/221079 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005929 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA ARPC4 http://www.ncbi.nlm.nih.gov/gene/26140 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005930 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA C1orf128 http://www.ncbi.nlm.nih.gov/gene/57095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005931 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA C6orf120 http://www.ncbi.nlm.nih.gov/gene/387263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005932 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA C8orf73 http://www.ncbi.nlm.nih.gov/gene/642475 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005933 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA CBFA2T2 http://www.ncbi.nlm.nih.gov/gene/9139 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005934 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005935 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA CD48 http://www.ncbi.nlm.nih.gov/gene/962 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005936 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA DCBLD2 http://www.ncbi.nlm.nih.gov/gene/131566 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005937 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA DCP2 http://www.ncbi.nlm.nih.gov/gene/167227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005938 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA DGKE http://www.ncbi.nlm.nih.gov/gene/8526 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005939 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA EFHD2 http://www.ncbi.nlm.nih.gov/gene/79180 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005940 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA EIF2S3 http://www.ncbi.nlm.nih.gov/gene/1968 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005941 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA EYA4 http://www.ncbi.nlm.nih.gov/gene/2070 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005942 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA FAM49B http://www.ncbi.nlm.nih.gov/gene/51571 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005943 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA FIP1L1 http://www.ncbi.nlm.nih.gov/gene/81608 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005944 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA FOXP2 http://www.ncbi.nlm.nih.gov/gene/93986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005945 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA GATAD1 http://www.ncbi.nlm.nih.gov/gene/57798 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005946 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA GOPC http://www.ncbi.nlm.nih.gov/gene/57120 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005947 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA HEATR5A http://www.ncbi.nlm.nih.gov/gene/25938 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005948 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA HECA http://www.ncbi.nlm.nih.gov/gene/51696 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005949 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA HS3ST3B1 http://www.ncbi.nlm.nih.gov/gene/9953 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005950 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA HSPA14 http://www.ncbi.nlm.nih.gov/gene/51182 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005951 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA IL2RB http://www.ncbi.nlm.nih.gov/gene/3560 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005952 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA JMY http://www.ncbi.nlm.nih.gov/gene/133746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005953 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA KIF2A http://www.ncbi.nlm.nih.gov/gene/3796 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005954 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA KTELC1 http://www.ncbi.nlm.nih.gov/gene/56983 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005955 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA MBD2 http://www.ncbi.nlm.nih.gov/gene/8932 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005956 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA MBLAC2 http://www.ncbi.nlm.nih.gov/gene/153364 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005957 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA MCL1 http://www.ncbi.nlm.nih.gov/gene/4170 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005958 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA MTPN http://www.ncbi.nlm.nih.gov/gene/767558 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005959 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA MYB http://www.ncbi.nlm.nih.gov/gene/4602 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005960 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA NLN http://www.ncbi.nlm.nih.gov/gene/57486 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005961 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA PDE7A http://www.ncbi.nlm.nih.gov/gene/5150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005962 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA PHTF2 http://www.ncbi.nlm.nih.gov/gene/57157 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005963 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA PLAG1 http://www.ncbi.nlm.nih.gov/gene/5324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005964 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA POFUT1 http://www.ncbi.nlm.nih.gov/gene/23509 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005965 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA PPAP2B http://www.ncbi.nlm.nih.gov/gene/8613 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005966 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA PPP1CB http://www.ncbi.nlm.nih.gov/gene/245711 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005967 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA PPP1R2 http://www.ncbi.nlm.nih.gov/gene/5504 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005968 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA PPP4R2 http://www.ncbi.nlm.nih.gov/gene/151987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005969 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA PRICKLE4 http://www.ncbi.nlm.nih.gov/gene/29964 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005970 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA RAB2B http://www.ncbi.nlm.nih.gov/gene/84932 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005971 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA RGL2 http://www.ncbi.nlm.nih.gov/gene/5863 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005972 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA SAMD9L http://www.ncbi.nlm.nih.gov/gene/219285 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005973 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA SEC24A http://www.ncbi.nlm.nih.gov/gene/10802 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005974 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA SLC35A5 http://www.ncbi.nlm.nih.gov/gene/55032 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005975 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA SLC39A13 http://www.ncbi.nlm.nih.gov/gene/91252 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005976 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA SNW1 http://www.ncbi.nlm.nih.gov/gene/22938 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005977 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA SNX11 http://www.ncbi.nlm.nih.gov/gene/29916 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005978 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA SOS1 http://www.ncbi.nlm.nih.gov/gene/6654 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005979 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA TBL1XR1 http://www.ncbi.nlm.nih.gov/gene/79718 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005980 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA TERF1 http://www.ncbi.nlm.nih.gov/gene/646316 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005981 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA TGOLN2 http://www.ncbi.nlm.nih.gov/gene/10618 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005982 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA TNRC6A http://www.ncbi.nlm.nih.gov/gene/27327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005983 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA TRIM32 http://www.ncbi.nlm.nih.gov/gene/22954 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005984 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA TSLP http://www.ncbi.nlm.nih.gov/gene/85480 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005985 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA USP31 http://www.ncbi.nlm.nih.gov/gene/57478 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005986 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA WDR1 http://www.ncbi.nlm.nih.gov/gene/9948 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005987 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA ZNF588 http://www.ncbi.nlm.nih.gov/gene/51427 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005988 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-11-5p(miR-K11*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015213 BC-3 - Host mRNA ZNF90 http://www.ncbi.nlm.nih.gov/gene/7643 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005989 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA ANKLE1 http://www.ncbi.nlm.nih.gov/gene/126549 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005990 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA AP2M1 http://www.ncbi.nlm.nih.gov/gene/1173 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005991 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA ARID1A http://www.ncbi.nlm.nih.gov/gene/8289 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005992 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA ASXL1 http://www.ncbi.nlm.nih.gov/gene/171023 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005993 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA ATP9A http://www.ncbi.nlm.nih.gov/gene/10079 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005994 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA BAT1 http://www.ncbi.nlm.nih.gov/gene/7919 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005995 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA BIRC2 http://www.ncbi.nlm.nih.gov/gene/329 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005996 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA C9orf25 http://www.ncbi.nlm.nih.gov/gene/203259 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005997 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA CPNE8 http://www.ncbi.nlm.nih.gov/gene/144402 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005998 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA DCAKD http://www.ncbi.nlm.nih.gov/gene/79877 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00005999 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA DCP1A http://www.ncbi.nlm.nih.gov/gene/55802 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006000 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA EPB41L4A http://www.ncbi.nlm.nih.gov/gene/64097 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006001 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA EXOSC3 http://www.ncbi.nlm.nih.gov/gene/51010 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006002 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA FBN1 http://www.ncbi.nlm.nih.gov/gene/2200 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006003 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA FLYWCH1 http://www.ncbi.nlm.nih.gov/gene/84256 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006004 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA FOXP2 http://www.ncbi.nlm.nih.gov/gene/93986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006005 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA GANAB http://www.ncbi.nlm.nih.gov/gene/23193 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006006 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA IGF1R http://www.ncbi.nlm.nih.gov/gene/3480 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006007 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA KDM2A http://www.ncbi.nlm.nih.gov/gene/22992 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006008 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA KIAA0494 http://www.ncbi.nlm.nih.gov/gene/9813 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006009 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA KLHL18 http://www.ncbi.nlm.nih.gov/gene/23276 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006010 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA LARP4 http://www.ncbi.nlm.nih.gov/gene/113251 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006011 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA LIX1L http://www.ncbi.nlm.nih.gov/gene/128077 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006012 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA LPIN1 http://www.ncbi.nlm.nih.gov/gene/23175 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006013 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA LRRC59 http://www.ncbi.nlm.nih.gov/gene/55379 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006014 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA MAP2K4 http://www.ncbi.nlm.nih.gov/gene/6416 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006015 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA MAP7D1 http://www.ncbi.nlm.nih.gov/gene/55700 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006016 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA MOBKL2A http://www.ncbi.nlm.nih.gov/gene/126308 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006017 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA MRRF http://www.ncbi.nlm.nih.gov/gene/92399 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006018 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA NAT13 http://www.ncbi.nlm.nih.gov/gene/80218 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006019 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA NSD1 http://www.ncbi.nlm.nih.gov/gene/64324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006020 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA NUAK1 http://www.ncbi.nlm.nih.gov/gene/9891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006021 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA OAS2 http://www.ncbi.nlm.nih.gov/gene/4939 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006022 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA PACS1 http://www.ncbi.nlm.nih.gov/gene/55690 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006023 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA PISD http://www.ncbi.nlm.nih.gov/gene/23761 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006024 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA PNPLA6 http://www.ncbi.nlm.nih.gov/gene/10908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006025 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA PRC1 http://www.ncbi.nlm.nih.gov/gene/9055 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006026 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA PSAP http://www.ncbi.nlm.nih.gov/gene/5660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006027 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA RBM23 http://www.ncbi.nlm.nih.gov/gene/55147 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006028 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA SCAMP2 http://www.ncbi.nlm.nih.gov/gene/10066 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006029 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA SEC24A http://www.ncbi.nlm.nih.gov/gene/10802 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006030 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA SETD5 http://www.ncbi.nlm.nih.gov/gene/55209 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006031 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA SLC9A8 http://www.ncbi.nlm.nih.gov/gene/23315 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006032 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA SPEN http://www.ncbi.nlm.nih.gov/gene/23013 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006033 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA SPRED2 http://www.ncbi.nlm.nih.gov/gene/200734 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006034 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA SUMF2 http://www.ncbi.nlm.nih.gov/gene/25870 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006035 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA TRAM2 http://www.ncbi.nlm.nih.gov/gene/9697 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006036 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA TRIM33 http://www.ncbi.nlm.nih.gov/gene/51592 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006037 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA TROVE2 http://www.ncbi.nlm.nih.gov/gene/6738 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006038 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA WDR34 http://www.ncbi.nlm.nih.gov/gene/89891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006039 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA WEE1 http://www.ncbi.nlm.nih.gov/gene/7465 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006040 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA WIZ http://www.ncbi.nlm.nih.gov/gene/58525 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006041 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA ZFC3H1 http://www.ncbi.nlm.nih.gov/gene/196441 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006042 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA ZNF131 http://www.ncbi.nlm.nih.gov/gene/7690 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006043 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA ZNF451 http://www.ncbi.nlm.nih.gov/gene/26036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006044 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ACTR2 http://www.ncbi.nlm.nih.gov/gene/10097 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006045 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ADAM10 http://www.ncbi.nlm.nih.gov/gene/102 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006046 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ANKIB1 http://www.ncbi.nlm.nih.gov/gene/54467 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006047 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ANKRD40 http://www.ncbi.nlm.nih.gov/gene/91369 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006048 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ANKRD50 http://www.ncbi.nlm.nih.gov/gene/57182 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006049 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ARFGAP2 http://www.ncbi.nlm.nih.gov/gene/84364 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006050 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ARPP19 http://www.ncbi.nlm.nih.gov/gene/646227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006051 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ATF2 http://www.ncbi.nlm.nih.gov/gene/1386 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006052 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ATP6V0A2 http://www.ncbi.nlm.nih.gov/gene/23545 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006053 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA BAZ1B http://www.ncbi.nlm.nih.gov/gene/9031 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006054 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA BTN3A3 http://www.ncbi.nlm.nih.gov/gene/10384 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006055 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA C10orf18 http://www.ncbi.nlm.nih.gov/gene/54906 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006056 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA C11orf58 http://www.ncbi.nlm.nih.gov/gene/10944 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006057 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA C14orf129 http://www.ncbi.nlm.nih.gov/gene/51527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006058 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA C14orf28 http://www.ncbi.nlm.nih.gov/gene/122525 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006059 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA C15orf23 http://www.ncbi.nlm.nih.gov/gene/90417 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006060 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA C20orf96 http://www.ncbi.nlm.nih.gov/gene/140680 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006061 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA C21orf91 http://www.ncbi.nlm.nih.gov/gene/54149 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006062 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA C22orf30 http://www.ncbi.nlm.nih.gov/gene/253143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006063 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA C3orf52 http://www.ncbi.nlm.nih.gov/gene/79669 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006064 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA C4orf34 http://www.ncbi.nlm.nih.gov/gene/201895 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006065 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA C5orf24 http://www.ncbi.nlm.nih.gov/gene/134553 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006066 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA C5orf30 http://www.ncbi.nlm.nih.gov/gene/90355 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006067 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA C6orf167 http://www.ncbi.nlm.nih.gov/gene/253714 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006068 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA C7orf44 http://www.ncbi.nlm.nih.gov/gene/55744 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006069 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA C7orf64 http://www.ncbi.nlm.nih.gov/gene/84060 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006070 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA C9orf40 http://www.ncbi.nlm.nih.gov/gene/55071 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006071 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA CAMSAP1L1 http://www.ncbi.nlm.nih.gov/gene/23271 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006072 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA CAV2 http://www.ncbi.nlm.nih.gov/gene/858 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006073 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA CBX1 http://www.ncbi.nlm.nih.gov/gene/10951 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006074 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA CCDC117 http://www.ncbi.nlm.nih.gov/gene/150275 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006075 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA CCDC6 http://www.ncbi.nlm.nih.gov/gene/8030 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006076 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA CCND2 http://www.ncbi.nlm.nih.gov/gene/894 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006077 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA CD200R1 http://www.ncbi.nlm.nih.gov/gene/131450 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006078 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA CDC73 http://www.ncbi.nlm.nih.gov/gene/79577 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006079 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA CDK6 http://www.ncbi.nlm.nih.gov/gene/1021 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006080 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA CENPQ http://www.ncbi.nlm.nih.gov/gene/55166 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006081 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA CGRRF1 http://www.ncbi.nlm.nih.gov/gene/10668 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006082 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA CHMP2B http://www.ncbi.nlm.nih.gov/gene/25978 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006083 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA CKAP2 http://www.ncbi.nlm.nih.gov/gene/26586 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006084 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA COPS7A http://www.ncbi.nlm.nih.gov/gene/50813 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006085 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA CPNE3 http://www.ncbi.nlm.nih.gov/gene/8895 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006086 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA CRISPLD1 http://www.ncbi.nlm.nih.gov/gene/83690 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006087 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA CSNK1G1 http://www.ncbi.nlm.nih.gov/gene/53944 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006088 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA CSNK1G3 http://www.ncbi.nlm.nih.gov/gene/1456 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006089 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA CSNK2A1 http://www.ncbi.nlm.nih.gov/gene/283106 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006090 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA CUL3 http://www.ncbi.nlm.nih.gov/gene/8452 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006091 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA CYB561D1 http://www.ncbi.nlm.nih.gov/gene/284613 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006092 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA DCK http://www.ncbi.nlm.nih.gov/gene/1633 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006093 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA DDI2 http://www.ncbi.nlm.nih.gov/gene/84301 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006094 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA DFFA http://www.ncbi.nlm.nih.gov/gene/1676 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006095 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA DHX15 http://www.ncbi.nlm.nih.gov/gene/1665 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006096 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA DIMT1L http://www.ncbi.nlm.nih.gov/gene/27292 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006097 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA DIP2B http://www.ncbi.nlm.nih.gov/gene/57609 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006098 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA DNAJC24 http://www.ncbi.nlm.nih.gov/gene/120526 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006099 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA DNMT3A http://www.ncbi.nlm.nih.gov/gene/1788 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006100 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA DONSON http://www.ncbi.nlm.nih.gov/gene/29980 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006101 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA DRAM1 http://www.ncbi.nlm.nih.gov/gene/55332 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006102 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA E2F7 http://www.ncbi.nlm.nih.gov/gene/144455 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006103 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA EDEM3 http://www.ncbi.nlm.nih.gov/gene/80267 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006104 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA EGLN1 http://www.ncbi.nlm.nih.gov/gene/54583 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006105 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA EHD4 http://www.ncbi.nlm.nih.gov/gene/30844 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006106 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA EIF2C2 http://www.ncbi.nlm.nih.gov/gene/27161 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006107 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA EIF4A2 http://www.ncbi.nlm.nih.gov/gene/286512 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006108 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ELK4 http://www.ncbi.nlm.nih.gov/gene/2005 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006109 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA EPC1 http://www.ncbi.nlm.nih.gov/gene/80314 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006110 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA EPM2AIP1 http://www.ncbi.nlm.nih.gov/gene/9852 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006111 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ERO1L http://www.ncbi.nlm.nih.gov/gene/30001 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006112 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ETNK1 http://www.ncbi.nlm.nih.gov/gene/55500 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006113 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA F2R http://www.ncbi.nlm.nih.gov/gene/2149 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006114 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA FAM105B http://www.ncbi.nlm.nih.gov/gene/90268 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006115 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA FAR1 http://www.ncbi.nlm.nih.gov/gene/84188 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006116 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA FBXO22 http://www.ncbi.nlm.nih.gov/gene/26263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006117 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA FECH http://www.ncbi.nlm.nih.gov/gene/2235 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006118 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA FEM1C http://www.ncbi.nlm.nih.gov/gene/56929 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006119 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA FNDC3B http://www.ncbi.nlm.nih.gov/gene/64778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006120 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA FOSL2 http://www.ncbi.nlm.nih.gov/gene/2355 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006121 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA FOXO3 http://www.ncbi.nlm.nih.gov/gene/2310 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006122 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA FXR1 http://www.ncbi.nlm.nih.gov/gene/8087 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006123 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA FZD6 http://www.ncbi.nlm.nih.gov/gene/8323 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006124 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA G3BP2 http://www.ncbi.nlm.nih.gov/gene/9908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006125 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA GOPC http://www.ncbi.nlm.nih.gov/gene/57120 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006126 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA GPR141 http://www.ncbi.nlm.nih.gov/gene/353345 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006127 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA GSK3B http://www.ncbi.nlm.nih.gov/gene/2932 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006128 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA GTF2F1 http://www.ncbi.nlm.nih.gov/gene/2962 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006129 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA GTF2H1 http://www.ncbi.nlm.nih.gov/gene/2965 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006130 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA HAT1 http://www.ncbi.nlm.nih.gov/gene/8520 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006131 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA HAUS5 http://www.ncbi.nlm.nih.gov/gene/23354 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006132 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA HCFC2 http://www.ncbi.nlm.nih.gov/gene/29915 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006133 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA HECTD1 http://www.ncbi.nlm.nih.gov/gene/25831 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006134 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA HIST1H4D http://www.ncbi.nlm.nih.gov/gene/8367 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006135 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA IER5 http://www.ncbi.nlm.nih.gov/gene/51278 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006136 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA IL6ST http://www.ncbi.nlm.nih.gov/gene/3572 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006137 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA INO80D http://www.ncbi.nlm.nih.gov/gene/54891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006138 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA IPMK http://www.ncbi.nlm.nih.gov/gene/253430 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006139 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA IPO7 http://www.ncbi.nlm.nih.gov/gene/10527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006140 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA IRF1 http://www.ncbi.nlm.nih.gov/gene/3659 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006141 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ITGAV http://www.ncbi.nlm.nih.gov/gene/3685 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006142 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA KATNAL1 http://www.ncbi.nlm.nih.gov/gene/84056 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006143 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA KIAA0146 http://www.ncbi.nlm.nih.gov/gene/23514 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006144 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA KIAA0232 http://www.ncbi.nlm.nih.gov/gene/9778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006145 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA KIAA1211 http://www.ncbi.nlm.nih.gov/gene/57482 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006146 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA KIAA1244 http://www.ncbi.nlm.nih.gov/gene/57221 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006147 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA KLF3 http://www.ncbi.nlm.nih.gov/gene/51274 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006148 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA KLHDC10 http://www.ncbi.nlm.nih.gov/gene/23008 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006149 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA KLHL14 http://www.ncbi.nlm.nih.gov/gene/57565 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006150 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA LANCL1 http://www.ncbi.nlm.nih.gov/gene/10314 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006151 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA LBR http://www.ncbi.nlm.nih.gov/gene/3930 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006152 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA LIN28B http://www.ncbi.nlm.nih.gov/gene/389421 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006153 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA LPIN2 http://www.ncbi.nlm.nih.gov/gene/9663 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006154 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA LRRC57 http://www.ncbi.nlm.nih.gov/gene/255252 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006155 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA LRRC59 http://www.ncbi.nlm.nih.gov/gene/55379 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006156 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA LUC7L2 http://www.ncbi.nlm.nih.gov/gene/51631 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006157 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA MAPK1 http://www.ncbi.nlm.nih.gov/gene/5594 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006158 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA MBNL1 http://www.ncbi.nlm.nih.gov/gene/4154 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006159 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA MBP http://www.ncbi.nlm.nih.gov/gene/4155 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006160 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA MCFD2 http://www.ncbi.nlm.nih.gov/gene/90411 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006161 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA MED13 http://www.ncbi.nlm.nih.gov/gene/9969 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006162 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA MED13L http://www.ncbi.nlm.nih.gov/gene/23389 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006163 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA MFAP3 http://www.ncbi.nlm.nih.gov/gene/4238 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006164 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA MGRN1 http://www.ncbi.nlm.nih.gov/gene/23295 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006165 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA MIER1 http://www.ncbi.nlm.nih.gov/gene/57708 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006166 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA MMGT1 http://www.ncbi.nlm.nih.gov/gene/93380 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006167 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA MOCS3 http://www.ncbi.nlm.nih.gov/gene/27304 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006168 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA MON2 http://www.ncbi.nlm.nih.gov/gene/23041 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006169 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA MSN http://www.ncbi.nlm.nih.gov/gene/4478 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006170 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA MTMR2 http://www.ncbi.nlm.nih.gov/gene/8898 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006171 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA MXD3 http://www.ncbi.nlm.nih.gov/gene/83463 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006172 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA N4BP2 http://www.ncbi.nlm.nih.gov/gene/55728 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006173 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA NAT12 http://www.ncbi.nlm.nih.gov/gene/122830 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006174 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA NBR1 http://www.ncbi.nlm.nih.gov/gene/4077 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006175 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA NDFIP1 http://www.ncbi.nlm.nih.gov/gene/80762 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006176 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA NEDD1 http://www.ncbi.nlm.nih.gov/gene/121441 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006177 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006178 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA NR2C2 http://www.ncbi.nlm.nih.gov/gene/7182 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006179 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA NUDT21 http://www.ncbi.nlm.nih.gov/gene/11051 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006180 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ORMDL3 http://www.ncbi.nlm.nih.gov/gene/94103 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006181 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA PALM2-AKAP2 http://www.ncbi.nlm.nih.gov/gene/114299 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006182 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA PAPOLG http://www.ncbi.nlm.nih.gov/gene/64895 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006183 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA PCGF5 http://www.ncbi.nlm.nih.gov/gene/84333 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006184 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA PCNX http://www.ncbi.nlm.nih.gov/gene/22990 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006185 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA PEBP1 http://www.ncbi.nlm.nih.gov/gene/5037 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006186 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA PELO http://www.ncbi.nlm.nih.gov/gene/53918 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006187 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA PFKM http://www.ncbi.nlm.nih.gov/gene/5213 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006188 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA PHF12 http://www.ncbi.nlm.nih.gov/gene/57649 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006189 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA PHF17 http://www.ncbi.nlm.nih.gov/gene/79960 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006190 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA PIGM http://www.ncbi.nlm.nih.gov/gene/93183 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006191 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA PIK3C2A http://www.ncbi.nlm.nih.gov/gene/5286 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006192 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA PIK3R3 http://www.ncbi.nlm.nih.gov/gene/8503 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006193 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA PLAG1 http://www.ncbi.nlm.nih.gov/gene/5324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006194 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA PLEKHF2 http://www.ncbi.nlm.nih.gov/gene/79666 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006195 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA POLQ http://www.ncbi.nlm.nih.gov/gene/10721 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006196 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA PPM1B http://www.ncbi.nlm.nih.gov/gene/5495 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006197 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA PPP2CA http://www.ncbi.nlm.nih.gov/gene/5515 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006198 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA PRC1 http://www.ncbi.nlm.nih.gov/gene/9055 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006199 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA PRPF40A http://www.ncbi.nlm.nih.gov/gene/55660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006200 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA PSMD12 http://www.ncbi.nlm.nih.gov/gene/5718 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006201 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA PUM2 http://www.ncbi.nlm.nih.gov/gene/23369 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006202 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA RAB11FIP2 http://www.ncbi.nlm.nih.gov/gene/22841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006203 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA RAB14 http://www.ncbi.nlm.nih.gov/gene/51552 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006204 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA RAB3GAP2 http://www.ncbi.nlm.nih.gov/gene/25782 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006205 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA RAB7A http://www.ncbi.nlm.nih.gov/gene/7879 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006206 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA RABIF http://www.ncbi.nlm.nih.gov/gene/5877 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006207 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA RAP2B http://www.ncbi.nlm.nih.gov/gene/5912 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006208 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA RASSF8 http://www.ncbi.nlm.nih.gov/gene/11228 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006209 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA RBM26 http://www.ncbi.nlm.nih.gov/gene/64062 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006210 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA REEP5 http://www.ncbi.nlm.nih.gov/gene/7905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006211 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA RERE http://www.ncbi.nlm.nih.gov/gene/473 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006212 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA RFK http://www.ncbi.nlm.nih.gov/gene/55312 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006213 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA RFX7 http://www.ncbi.nlm.nih.gov/gene/64864 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006214 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA RIF1 http://www.ncbi.nlm.nih.gov/gene/55183 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006215 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA RPL34 http://www.ncbi.nlm.nih.gov/gene/6164 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006216 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA RPRD1A http://www.ncbi.nlm.nih.gov/gene/55197 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006217 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA RPRD2 http://www.ncbi.nlm.nih.gov/gene/23248 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006218 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA RRM2B http://www.ncbi.nlm.nih.gov/gene/50484 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006219 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA RSBN1 http://www.ncbi.nlm.nih.gov/gene/54665 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006220 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA RSRC2 http://www.ncbi.nlm.nih.gov/gene/65117 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006221 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA SCOC http://www.ncbi.nlm.nih.gov/gene/60592 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006222 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA SEC63 http://www.ncbi.nlm.nih.gov/gene/11231 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006223 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA SENP5 http://www.ncbi.nlm.nih.gov/gene/205564 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006224 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA SESTD1 http://www.ncbi.nlm.nih.gov/gene/91404 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006225 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA SFRS1 http://www.ncbi.nlm.nih.gov/gene/6426 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006226 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA SFRS18 http://www.ncbi.nlm.nih.gov/gene/25957 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006227 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA SHCBP1 http://www.ncbi.nlm.nih.gov/gene/79801 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006228 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA SHOC2 http://www.ncbi.nlm.nih.gov/gene/8036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006229 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA SIRT5 http://www.ncbi.nlm.nih.gov/gene/23408 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006230 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA SKI http://www.ncbi.nlm.nih.gov/gene/6497 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006231 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA SLC33A1 http://www.ncbi.nlm.nih.gov/gene/9197 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006232 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA SLC9A6 http://www.ncbi.nlm.nih.gov/gene/10479 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006233 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA SMAD5 http://www.ncbi.nlm.nih.gov/gene/4090 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006234 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA SMAP1 http://www.ncbi.nlm.nih.gov/gene/60682 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006235 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA SMURF2 http://www.ncbi.nlm.nih.gov/gene/64750 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006236 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA SNX9 http://www.ncbi.nlm.nih.gov/gene/51429 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006237 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA SOD2 http://www.ncbi.nlm.nih.gov/gene/6648 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006238 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA SP3 http://www.ncbi.nlm.nih.gov/gene/6670 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006239 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA STRBP http://www.ncbi.nlm.nih.gov/gene/55342 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006240 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA STXBP4 http://www.ncbi.nlm.nih.gov/gene/252983 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006241 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA TAF2 http://www.ncbi.nlm.nih.gov/gene/6873 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006242 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA TAF4B http://www.ncbi.nlm.nih.gov/gene/6875 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006243 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA TANC2 http://www.ncbi.nlm.nih.gov/gene/26115 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006244 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA TFB1M http://www.ncbi.nlm.nih.gov/gene/51106 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006245 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA THAP2 http://www.ncbi.nlm.nih.gov/gene/83591 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006246 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA THOC2 http://www.ncbi.nlm.nih.gov/gene/57187 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006247 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA TMEM170A http://www.ncbi.nlm.nih.gov/gene/124491 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006248 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA TMPO http://www.ncbi.nlm.nih.gov/gene/7112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006249 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA TNPO1 http://www.ncbi.nlm.nih.gov/gene/3842 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006250 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA TNRC6B http://www.ncbi.nlm.nih.gov/gene/23112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006251 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA TPT1 http://www.ncbi.nlm.nih.gov/gene/389787 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006252 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA TRAM1 http://www.ncbi.nlm.nih.gov/gene/23471 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006253 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA TRAPPC6B http://www.ncbi.nlm.nih.gov/gene/122553 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006254 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA TRDMT1 http://www.ncbi.nlm.nih.gov/gene/1787 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006255 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA TRIM23 http://www.ncbi.nlm.nih.gov/gene/373 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006256 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA TSC1 http://www.ncbi.nlm.nih.gov/gene/7248 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006257 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA TSHZ1 http://www.ncbi.nlm.nih.gov/gene/10194 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006258 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA TTC35 http://www.ncbi.nlm.nih.gov/gene/9694 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006259 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA TWISTNB http://www.ncbi.nlm.nih.gov/gene/221830 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006260 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA UBE2W http://www.ncbi.nlm.nih.gov/gene/55284 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006261 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA UBR3 http://www.ncbi.nlm.nih.gov/gene/130507 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006262 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA UBTF http://www.ncbi.nlm.nih.gov/gene/7343 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006263 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA VHL http://www.ncbi.nlm.nih.gov/gene/7428 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006264 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA WASL http://www.ncbi.nlm.nih.gov/gene/8976 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006265 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA WDR48 http://www.ncbi.nlm.nih.gov/gene/57599 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006266 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA WHSC1 http://www.ncbi.nlm.nih.gov/gene/7468 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006267 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA XRN2 http://www.ncbi.nlm.nih.gov/gene/22803 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006268 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA XYLB http://www.ncbi.nlm.nih.gov/gene/9942 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006269 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA YWHAG http://www.ncbi.nlm.nih.gov/gene/7532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006270 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ZBTB34 http://www.ncbi.nlm.nih.gov/gene/403341 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006271 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ZBTB38 http://www.ncbi.nlm.nih.gov/gene/253461 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006272 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ZC3H13 http://www.ncbi.nlm.nih.gov/gene/23091 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006273 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ZC3H6 http://www.ncbi.nlm.nih.gov/gene/376940 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006274 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ZFP91 http://www.ncbi.nlm.nih.gov/gene/386607 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006275 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ZHX1 http://www.ncbi.nlm.nih.gov/gene/11244 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006276 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ZKSCAN1 http://www.ncbi.nlm.nih.gov/gene/7586 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006277 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ZMAT3 http://www.ncbi.nlm.nih.gov/gene/64393 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006278 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ZNF12 http://www.ncbi.nlm.nih.gov/gene/7559 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006279 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ZNF295 http://www.ncbi.nlm.nih.gov/gene/49854 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006280 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ZNF37A http://www.ncbi.nlm.nih.gov/gene/7587 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006281 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ZNF518A http://www.ncbi.nlm.nih.gov/gene/9849 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006282 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ZNF680 http://www.ncbi.nlm.nih.gov/gene/340252 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006283 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ZNF681 http://www.ncbi.nlm.nih.gov/gene/148213 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006284 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ZNF791 http://www.ncbi.nlm.nih.gov/gene/163049 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006285 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ZNF805 http://www.ncbi.nlm.nih.gov/gene/390980 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006286 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ZNF91 http://www.ncbi.nlm.nih.gov/gene/7644 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006287 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-1 - Host mRNA ZYG11A http://www.ncbi.nlm.nih.gov/gene/440590 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006288 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA ABCB8 http://www.ncbi.nlm.nih.gov/gene/11194 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006289 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA ACTR2 http://www.ncbi.nlm.nih.gov/gene/10097 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006290 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA ANKRD40 http://www.ncbi.nlm.nih.gov/gene/91369 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006291 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA ANO6 http://www.ncbi.nlm.nih.gov/gene/196527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006292 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA ARFGAP2 http://www.ncbi.nlm.nih.gov/gene/84364 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006293 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA ATP6V0A2 http://www.ncbi.nlm.nih.gov/gene/23545 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006294 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA ATXN7L1 http://www.ncbi.nlm.nih.gov/gene/222255 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006295 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA C10orf18 http://www.ncbi.nlm.nih.gov/gene/54906 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006296 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA C12orf23 http://www.ncbi.nlm.nih.gov/gene/90488 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006297 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA C15orf23 http://www.ncbi.nlm.nih.gov/gene/90417 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006298 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA C20orf96 http://www.ncbi.nlm.nih.gov/gene/140680 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006299 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA C3orf52 http://www.ncbi.nlm.nih.gov/gene/79669 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006300 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA C7orf44 http://www.ncbi.nlm.nih.gov/gene/55744 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006301 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA C9orf40 http://www.ncbi.nlm.nih.gov/gene/55071 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006302 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA CCDC102B http://www.ncbi.nlm.nih.gov/gene/79839 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006303 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA CCND2 http://www.ncbi.nlm.nih.gov/gene/894 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006304 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA CD200R1 http://www.ncbi.nlm.nih.gov/gene/131450 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006305 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA CDK6 http://www.ncbi.nlm.nih.gov/gene/1021 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006306 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA CENPQ http://www.ncbi.nlm.nih.gov/gene/55166 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006307 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA CGRRF1 http://www.ncbi.nlm.nih.gov/gene/10668 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006308 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA CHFR http://www.ncbi.nlm.nih.gov/gene/55743 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006309 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA COPA http://www.ncbi.nlm.nih.gov/gene/1314 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006310 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA CRISPLD1 http://www.ncbi.nlm.nih.gov/gene/83690 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006311 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA CRLF3 http://www.ncbi.nlm.nih.gov/gene/51379 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006312 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA CSNK1G3 http://www.ncbi.nlm.nih.gov/gene/1456 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006313 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA CUL3 http://www.ncbi.nlm.nih.gov/gene/8452 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006314 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA CYB561D1 http://www.ncbi.nlm.nih.gov/gene/284613 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006315 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA DARS http://www.ncbi.nlm.nih.gov/gene/1615 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006316 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA DCK http://www.ncbi.nlm.nih.gov/gene/1633 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006317 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA DHX15 http://www.ncbi.nlm.nih.gov/gene/1665 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006318 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA DIP2B http://www.ncbi.nlm.nih.gov/gene/57609 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006319 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA DONSON http://www.ncbi.nlm.nih.gov/gene/29980 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006320 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA E2F7 http://www.ncbi.nlm.nih.gov/gene/144455 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006321 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA EGLN1 http://www.ncbi.nlm.nih.gov/gene/54583 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006322 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA EHD4 http://www.ncbi.nlm.nih.gov/gene/30844 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006323 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA EIF1AY http://www.ncbi.nlm.nih.gov/gene/9086 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006324 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA EIF4A2 http://www.ncbi.nlm.nih.gov/gene/286512 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006325 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA EPHA5 http://www.ncbi.nlm.nih.gov/gene/2044 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006326 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA ERO1L http://www.ncbi.nlm.nih.gov/gene/30001 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006327 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA FADD http://www.ncbi.nlm.nih.gov/gene/8772 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006328 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA FAM105B http://www.ncbi.nlm.nih.gov/gene/90268 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006329 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA FAM169A http://www.ncbi.nlm.nih.gov/gene/26049 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006330 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA FAR1 http://www.ncbi.nlm.nih.gov/gene/84188 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006331 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA FEM1C http://www.ncbi.nlm.nih.gov/gene/56929 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006332 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA FOXJ3 http://www.ncbi.nlm.nih.gov/gene/22887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006333 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA FUNDC2 http://www.ncbi.nlm.nih.gov/gene/65991 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006334 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA GLT8D3 http://www.ncbi.nlm.nih.gov/gene/283464 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006335 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA GOPC http://www.ncbi.nlm.nih.gov/gene/57120 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006336 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA GPD2 http://www.ncbi.nlm.nih.gov/gene/2820 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006337 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA GPN1 http://www.ncbi.nlm.nih.gov/gene/11321 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006338 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA GSK3B http://www.ncbi.nlm.nih.gov/gene/2932 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006339 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA GTF2F1 http://www.ncbi.nlm.nih.gov/gene/2962 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006340 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA GTF2H1 http://www.ncbi.nlm.nih.gov/gene/2965 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006341 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA HECTD1 http://www.ncbi.nlm.nih.gov/gene/25831 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006342 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA HIST1H4D http://www.ncbi.nlm.nih.gov/gene/8367 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006343 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA HNRNPH1 http://www.ncbi.nlm.nih.gov/gene/3187 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006344 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA IFITM1 http://www.ncbi.nlm.nih.gov/gene/8519 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006345 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA IKZF1 http://www.ncbi.nlm.nih.gov/gene/10320 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006346 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA INO80D http://www.ncbi.nlm.nih.gov/gene/54891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006347 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA IPO7 http://www.ncbi.nlm.nih.gov/gene/10527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006348 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA ITGAV http://www.ncbi.nlm.nih.gov/gene/3685 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006349 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA KATNAL1 http://www.ncbi.nlm.nih.gov/gene/84056 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006350 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA KIAA0146 http://www.ncbi.nlm.nih.gov/gene/23514 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006351 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA KIAA1211 http://www.ncbi.nlm.nih.gov/gene/57482 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006352 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA KIAA1244 http://www.ncbi.nlm.nih.gov/gene/57221 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006353 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA KLF3 http://www.ncbi.nlm.nih.gov/gene/51274 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006354 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA KLHDC10 http://www.ncbi.nlm.nih.gov/gene/23008 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006355 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA LPIN2 http://www.ncbi.nlm.nih.gov/gene/9663 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006356 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA LRRC57 http://www.ncbi.nlm.nih.gov/gene/255252 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006357 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA LY75 http://www.ncbi.nlm.nih.gov/gene/4065 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006358 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA MAPK1 http://www.ncbi.nlm.nih.gov/gene/5594 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006359 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA MCFD2 http://www.ncbi.nlm.nih.gov/gene/90411 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006360 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA MED13 http://www.ncbi.nlm.nih.gov/gene/9969 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006361 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA MED13L http://www.ncbi.nlm.nih.gov/gene/23389 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006362 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA MGRN1 http://www.ncbi.nlm.nih.gov/gene/23295 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006363 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA MIER1 http://www.ncbi.nlm.nih.gov/gene/57708 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006364 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA MLL5 http://www.ncbi.nlm.nih.gov/gene/55904 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006365 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA MMGT1 http://www.ncbi.nlm.nih.gov/gene/93380 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006366 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA MOBKL3 http://www.ncbi.nlm.nih.gov/gene/25843 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006367 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA MON2 http://www.ncbi.nlm.nih.gov/gene/23041 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006368 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA MSN http://www.ncbi.nlm.nih.gov/gene/4478 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006369 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA MTAP http://www.ncbi.nlm.nih.gov/gene/4507 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006370 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA NBR1 http://www.ncbi.nlm.nih.gov/gene/4077 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006371 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA NR2C2 http://www.ncbi.nlm.nih.gov/gene/7182 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006372 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA NUDT21 http://www.ncbi.nlm.nih.gov/gene/11051 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006373 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA NUP153 http://www.ncbi.nlm.nih.gov/gene/9972 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006374 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA PAPOLG http://www.ncbi.nlm.nih.gov/gene/64895 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006375 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA PCNX http://www.ncbi.nlm.nih.gov/gene/22990 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006376 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA PCTP http://www.ncbi.nlm.nih.gov/gene/58488 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006377 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA PEBP1 http://www.ncbi.nlm.nih.gov/gene/5037 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006378 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA PELO http://www.ncbi.nlm.nih.gov/gene/53918 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006379 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA PEX3 http://www.ncbi.nlm.nih.gov/gene/8504 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006380 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA PHF17 http://www.ncbi.nlm.nih.gov/gene/79960 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006381 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA PIGM http://www.ncbi.nlm.nih.gov/gene/93183 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006382 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA PIK3R3 http://www.ncbi.nlm.nih.gov/gene/8503 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006383 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA PLCXD3 http://www.ncbi.nlm.nih.gov/gene/345557 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006384 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA PLS3 http://www.ncbi.nlm.nih.gov/gene/5358 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006385 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA PM20D2 http://www.ncbi.nlm.nih.gov/gene/135293 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006386 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA POLQ http://www.ncbi.nlm.nih.gov/gene/10721 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006387 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA PPAPDC2 http://www.ncbi.nlm.nih.gov/gene/403313 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006388 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA PPM1B http://www.ncbi.nlm.nih.gov/gene/5495 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006389 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA PSIP1 http://www.ncbi.nlm.nih.gov/gene/11168 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006390 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA PSMD12 http://www.ncbi.nlm.nih.gov/gene/5718 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006391 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA PUM2 http://www.ncbi.nlm.nih.gov/gene/23369 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006392 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA RAB11FIP2 http://www.ncbi.nlm.nih.gov/gene/22841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006393 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA RAB7A http://www.ncbi.nlm.nih.gov/gene/7879 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006394 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA RABIF http://www.ncbi.nlm.nih.gov/gene/5877 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006395 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA RAD18 http://www.ncbi.nlm.nih.gov/gene/56852 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006396 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA RARB http://www.ncbi.nlm.nih.gov/gene/5915 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006397 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA RARS2 http://www.ncbi.nlm.nih.gov/gene/57038 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006398 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA RASSF8 http://www.ncbi.nlm.nih.gov/gene/11228 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006399 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA RBM26 http://www.ncbi.nlm.nih.gov/gene/64062 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006400 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA RDH10 http://www.ncbi.nlm.nih.gov/gene/157506 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006401 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA RERE http://www.ncbi.nlm.nih.gov/gene/473 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006402 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA RFK http://www.ncbi.nlm.nih.gov/gene/55312 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006403 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA RIF1 http://www.ncbi.nlm.nih.gov/gene/55183 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006404 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA RNF170 http://www.ncbi.nlm.nih.gov/gene/81790 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006405 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA RPL34 http://www.ncbi.nlm.nih.gov/gene/6164 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006406 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA RPRD2 http://www.ncbi.nlm.nih.gov/gene/23248 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006407 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA RRM2B http://www.ncbi.nlm.nih.gov/gene/50484 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006408 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA SEC24A http://www.ncbi.nlm.nih.gov/gene/10802 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006409 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA SENP5 http://www.ncbi.nlm.nih.gov/gene/205564 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006410 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA SFRS1 http://www.ncbi.nlm.nih.gov/gene/6426 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006411 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA SFRS18 http://www.ncbi.nlm.nih.gov/gene/25957 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006412 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA SHOC2 http://www.ncbi.nlm.nih.gov/gene/8036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006413 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA SLC33A1 http://www.ncbi.nlm.nih.gov/gene/9197 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006414 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA SLC40A1 http://www.ncbi.nlm.nih.gov/gene/30061 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006415 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA SLC9A6 http://www.ncbi.nlm.nih.gov/gene/10479 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006416 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA SMAP1 http://www.ncbi.nlm.nih.gov/gene/60682 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006417 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA SRPR http://www.ncbi.nlm.nih.gov/gene/6734 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006418 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA STX12 http://www.ncbi.nlm.nih.gov/gene/23673 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006419 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA TAF2 http://www.ncbi.nlm.nih.gov/gene/6873 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006420 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA TAF4B http://www.ncbi.nlm.nih.gov/gene/6875 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006421 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA TIAL1 http://www.ncbi.nlm.nih.gov/gene/7073 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006422 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA TMEM170A http://www.ncbi.nlm.nih.gov/gene/124491 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006423 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA TMPO http://www.ncbi.nlm.nih.gov/gene/7112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006424 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA TNRC6B http://www.ncbi.nlm.nih.gov/gene/23112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006425 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA TRAM1 http://www.ncbi.nlm.nih.gov/gene/23471 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006426 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA TTC35 http://www.ncbi.nlm.nih.gov/gene/9694 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006427 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA TWISTNB http://www.ncbi.nlm.nih.gov/gene/221830 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006428 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA UBTF http://www.ncbi.nlm.nih.gov/gene/7343 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006429 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA VEPH1 http://www.ncbi.nlm.nih.gov/gene/79674 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006430 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA WASL http://www.ncbi.nlm.nih.gov/gene/8976 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006431 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA WDR48 http://www.ncbi.nlm.nih.gov/gene/57599 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006432 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA WHSC1 http://www.ncbi.nlm.nih.gov/gene/7468 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006433 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA XRN2 http://www.ncbi.nlm.nih.gov/gene/22803 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006434 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA YWHAG http://www.ncbi.nlm.nih.gov/gene/7532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006435 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA ZC3H13 http://www.ncbi.nlm.nih.gov/gene/23091 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006436 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA ZHX1 http://www.ncbi.nlm.nih.gov/gene/11244 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006437 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA ZKSCAN1 http://www.ncbi.nlm.nih.gov/gene/7586 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006438 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA ZMAT3 http://www.ncbi.nlm.nih.gov/gene/64393 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006439 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA ZNF12 http://www.ncbi.nlm.nih.gov/gene/7559 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006440 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA ZNF295 http://www.ncbi.nlm.nih.gov/gene/49854 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006441 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA ZNF680 http://www.ncbi.nlm.nih.gov/gene/340252 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006442 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA ZNF681 http://www.ncbi.nlm.nih.gov/gene/148213 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006443 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA ZNF805 http://www.ncbi.nlm.nih.gov/gene/390980 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006444 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA ZNF91 http://www.ncbi.nlm.nih.gov/gene/7644 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006445 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2(miR-K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC-3 - Host mRNA ZYG11A http://www.ncbi.nlm.nih.gov/gene/440590 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006446 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-1 - Host mRNA AASDHPPT http://www.ncbi.nlm.nih.gov/gene/60496 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006447 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-1 - Host mRNA C1orf83 http://www.ncbi.nlm.nih.gov/gene/127428 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006448 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-1 - Host mRNA ECT2 http://www.ncbi.nlm.nih.gov/gene/1894 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006449 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-1 - Host mRNA EPDR1 http://www.ncbi.nlm.nih.gov/gene/54749 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006450 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-1 - Host mRNA HGF http://www.ncbi.nlm.nih.gov/gene/3082 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006451 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-1 - Host mRNA IPO5 http://www.ncbi.nlm.nih.gov/gene/3843 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006452 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-1 - Host mRNA KLHL11 http://www.ncbi.nlm.nih.gov/gene/55175 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006453 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-1 - Host mRNA NUFIP2 http://www.ncbi.nlm.nih.gov/gene/57532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006454 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-1 - Host mRNA PTAR1 http://www.ncbi.nlm.nih.gov/gene/375743 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006455 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-1 - Host mRNA RACGAP1P http://www.ncbi.nlm.nih.gov/gene/29127 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006456 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-1 - Host mRNA SNX3 http://www.ncbi.nlm.nih.gov/gene/8724 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006457 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-1 - Host mRNA SSR2 http://www.ncbi.nlm.nih.gov/gene/6746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006458 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-1 - Host mRNA TTC7B http://www.ncbi.nlm.nih.gov/gene/145567 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006459 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-1 - Host mRNA VPS4B http://www.ncbi.nlm.nih.gov/gene/9525 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006460 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-1 - Host mRNA ZNF295 http://www.ncbi.nlm.nih.gov/gene/49854 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006461 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-3 - Host mRNA CBLN3 http://www.ncbi.nlm.nih.gov/gene/643866 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006462 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-3 - Host mRNA CLIC4 http://www.ncbi.nlm.nih.gov/gene/25932 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006463 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-3 - Host mRNA DDX21 http://www.ncbi.nlm.nih.gov/gene/9188 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006464 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-3 - Host mRNA ECT2 http://www.ncbi.nlm.nih.gov/gene/1894 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006465 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-3 - Host mRNA FXN http://www.ncbi.nlm.nih.gov/gene/2395 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006466 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-3 - Host mRNA KBTBD2 http://www.ncbi.nlm.nih.gov/gene/25948 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006467 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-3 - Host mRNA NUFIP2 http://www.ncbi.nlm.nih.gov/gene/57532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006468 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-3 - Host mRNA PTAR1 http://www.ncbi.nlm.nih.gov/gene/375743 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006469 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-3 - Host mRNA RACGAP1P http://www.ncbi.nlm.nih.gov/gene/29127 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006470 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-3 - Host mRNA RARB http://www.ncbi.nlm.nih.gov/gene/5915 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006471 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-3 - Host mRNA S100A6 http://www.ncbi.nlm.nih.gov/gene/6277 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006472 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-3 - Host mRNA SELPLG http://www.ncbi.nlm.nih.gov/gene/6404 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006473 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-2-3p(miR-K2*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015215 BC-3 - Host mRNA SNX16 http://www.ncbi.nlm.nih.gov/gene/64089 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006474 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-3 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 - - Host Protein LRRC8D http://www.ncbi.nlm.nih.gov/gene/55144 Downregulation Modeling of possible hybrids, derepression assays by using a 20-O-methyl RNA complementary. 20413099 LRRC8D Is Regulated by kshv-miR-K12-3 througha Single Target Site in Its 3'UTR.Modeling of possible hybrids between the LRRC8D 3'UTR and the KSHV-encoded miRNAs suggested a strong interaction of the 3'UTR with kshv-miR-K12-3. VHID00006475 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 - Upregulation Host Protein NFIB http://www.ncbi.nlm.nih.gov/gene/4781 Downregulation Reporter assay, miRNA and shRNA expression. 20847741 In this study, we show that KSHV miR-K3 can regulate viral latency by targeting nuclear factor I/B (NFIB). Both viral lytic replication and gene expression were inhibited by overexpressing miR-K3 or depleting NFIB. These findings suggest a role for KSHV miRNAs in regulating the viral life cycle. VHID00006476 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-3-3p(miR-K12-3-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002194 - - Host Protein THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00006477 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-3-3p(miR-K12-3-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002194 293 Cells - Host Protein THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 Downregulation Luciferase de-repression assay. 17500590 We performed luciferase de-repression assays by co-transfection of the THBS1 3'UTR reporter and 2'OMe RNAs specific to individual KSHV miRNAs. Our results demonstrate that THBS1 is targeted by multiple KSHV miRNAs; in particular, miR-K12-1, miR-K12-3-3p, miR-K12-6-3p, and miR-K12-11 lead to strong de-repression of the reporter. VHID00006478 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-3-3p(miR-K3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002194 BC-1 - Host mRNA B4GALT1 http://www.ncbi.nlm.nih.gov/gene/2683 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006479 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-3-3p(miR-K3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002194 BC-1 - Host mRNA PRKAA1 http://www.ncbi.nlm.nih.gov/gene/5562 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006480 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-3-3p(miR-K3-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002194 - - Host Protein THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00006481 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 - - Host Protein GEMIN8 http://www.ncbi.nlm.nih.gov/gene/54960 Downregulation 3'UTR dual-luciferase assay. 20413099 We identified a high confidence interaction site for kshv-miR-K12-4-3p in the coding sequence of GEMIN8 and for kshv-miR-K12-3 in the coding sequence of NHP2L1. VHID00006482 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC3 - Host mRNA CASP3 http://www.ncbi.nlm.nih.gov/gene/836 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00006483 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC3 - Host mRNA GEMIN8 http://www.ncbi.nlm.nih.gov/gene/54960 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00006484 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC3 - Host mRNA NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00006485 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BCBL1 - Host mRNA GEMIN8 http://www.ncbi.nlm.nih.gov/gene/54960 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00006486 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BCBL1 - Host mRNA NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00006487 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K12-4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 - - Host Protein GEMIN8 http://www.ncbi.nlm.nih.gov/gene/54960 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00006488 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K12-4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 - - Host Protein MCC http://www.ncbi.nlm.nih.gov/gene/4163 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00006489 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K12-4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 - - Host Protein NHP2L1 http://www.ncbi.nlm.nih.gov/gene/4809 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00006490 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K12-4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 - - Host mRNA CASP3 http://www.ncbi.nlm.nih.gov/gene/836 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00006491 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K12-4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 DG-75-K10/12 cells - Host Protein CASP3 http://www.ncbi.nlm.nih.gov/gene/836 Downregulation Northern blot analysis, Real-time PCR, Luciferase assays, Small RNA cloning and sequencing, Western blot analysis. 22174674 We found that three KSHV miRNAs, miR-K12-1, 3 and 4-3p, were responsible for the targeting of Casp3.Potential cellular targets that were significantly down-regulated upon KSHV miRNAs expression were identified by microarray profiling. VHID00006492 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K12-4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 HEK293 cells - Host Protein CASP3 http://www.ncbi.nlm.nih.gov/gene/836 - Luciferase assays,quantitative PCR and western blotting. 22174674 we validated by luciferase reporter assays, quantitative PCR and western blotting caspase 3 (Casp3), a critical factor for the control of apoptosis. Using site-directed mutagenesis, we found that three KSHV miRNAs, miR-K12-1, 3 and 4-3p, were responsible for the targeting of Casp3. . VHID00006493 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K12-4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 Lymphocytes - Host Protein GEMIN8 http://www.ncbi.nlm.nih.gov/gene/54960 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 miR-K12-4-3p suppression of GEMIN8,miR-K12-1, -6, and -11 decrease of MAF(musculoaponeurotic fibrosarcoma oncogene homolog).. VHID00006494 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ABL2 http://www.ncbi.nlm.nih.gov/gene/27 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006495 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ACSL1 http://www.ncbi.nlm.nih.gov/gene/2180 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006496 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ADIPOR2 http://www.ncbi.nlm.nih.gov/gene/79602 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006497 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA AMMECR1L http://www.ncbi.nlm.nih.gov/gene/83607 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006498 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ANGEL2 http://www.ncbi.nlm.nih.gov/gene/90806 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006499 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA AP1S3 http://www.ncbi.nlm.nih.gov/gene/130340 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006500 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA AP3M1 http://www.ncbi.nlm.nih.gov/gene/26985 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006501 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA APTX http://www.ncbi.nlm.nih.gov/gene/54840 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006502 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ARFGEF1 http://www.ncbi.nlm.nih.gov/gene/10565 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006503 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ARFIP1 http://www.ncbi.nlm.nih.gov/gene/27236 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006504 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ARIH1 http://www.ncbi.nlm.nih.gov/gene/25820 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006505 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ARL5A http://www.ncbi.nlm.nih.gov/gene/26225 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006506 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ARL5B http://www.ncbi.nlm.nih.gov/gene/221079 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006507 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ARL6IP1 http://www.ncbi.nlm.nih.gov/gene/23204 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006508 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ARNT http://www.ncbi.nlm.nih.gov/gene/405 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006509 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ATE1 http://www.ncbi.nlm.nih.gov/gene/11101 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006510 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ATP6V0E1 http://www.ncbi.nlm.nih.gov/gene/8992 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006511 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ATP6V1A http://www.ncbi.nlm.nih.gov/gene/523 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006512 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ATXN1 http://www.ncbi.nlm.nih.gov/gene/6310 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006513 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA B4GALT6 http://www.ncbi.nlm.nih.gov/gene/9331 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006514 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA BBX http://www.ncbi.nlm.nih.gov/gene/56987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006515 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA BICD2 http://www.ncbi.nlm.nih.gov/gene/23299 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006516 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA BTAF1 http://www.ncbi.nlm.nih.gov/gene/9044 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006517 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA BTBD3 http://www.ncbi.nlm.nih.gov/gene/22903 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006518 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA C12orf5 http://www.ncbi.nlm.nih.gov/gene/57103 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006519 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA C14orf2 http://www.ncbi.nlm.nih.gov/gene/9556 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006520 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA C16orf72 http://www.ncbi.nlm.nih.gov/gene/29035 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006521 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA C20orf112 http://www.ncbi.nlm.nih.gov/gene/140688 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006522 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA C4orf46 http://www.ncbi.nlm.nih.gov/gene/201725 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006523 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA C5orf24 http://www.ncbi.nlm.nih.gov/gene/134553 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006524 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA C9orf126 http://www.ncbi.nlm.nih.gov/gene/286205 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006525 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA C9orf41 http://www.ncbi.nlm.nih.gov/gene/138199 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006526 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA C9orf91 http://www.ncbi.nlm.nih.gov/gene/203197 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006527 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA CAMKK2 http://www.ncbi.nlm.nih.gov/gene/10645 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006528 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA CAMSAP1 http://www.ncbi.nlm.nih.gov/gene/157922 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006529 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA CAMSAP1L1 http://www.ncbi.nlm.nih.gov/gene/23271 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006530 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA CARD8 http://www.ncbi.nlm.nih.gov/gene/22900 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006531 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA CASP3 http://www.ncbi.nlm.nih.gov/gene/836 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006532 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA CCDC50 http://www.ncbi.nlm.nih.gov/gene/152137 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006533 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA CCNG1 http://www.ncbi.nlm.nih.gov/gene/900 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006534 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006535 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA CDC2L5 http://www.ncbi.nlm.nih.gov/gene/8621 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006536 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA CDC42SE1 http://www.ncbi.nlm.nih.gov/gene/56882 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006537 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA CHIC1 http://www.ncbi.nlm.nih.gov/gene/53344 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006538 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA CHIC2 http://www.ncbi.nlm.nih.gov/gene/26511 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006539 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA CLP1 http://www.ncbi.nlm.nih.gov/gene/10978 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006540 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA COBLL1 http://www.ncbi.nlm.nih.gov/gene/22837 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006541 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA CPD http://www.ncbi.nlm.nih.gov/gene/1362 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006542 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA CPEB3 http://www.ncbi.nlm.nih.gov/gene/22849 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006543 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA CPEB4 http://www.ncbi.nlm.nih.gov/gene/80315 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006544 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA CUL3 http://www.ncbi.nlm.nih.gov/gene/8452 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006545 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA DDI2 http://www.ncbi.nlm.nih.gov/gene/84301 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006546 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA DDX21 http://www.ncbi.nlm.nih.gov/gene/9188 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006547 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA DHX40 http://www.ncbi.nlm.nih.gov/gene/100134387 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006548 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA DLG1 http://www.ncbi.nlm.nih.gov/gene/1739 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006549 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA DNAJB4 http://www.ncbi.nlm.nih.gov/gene/11080 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006550 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA DNAJB9 http://www.ncbi.nlm.nih.gov/gene/4189 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006551 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA DNM2 http://www.ncbi.nlm.nih.gov/gene/1785 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006552 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA EPDR1 http://www.ncbi.nlm.nih.gov/gene/54749 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006553 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA EPRS http://www.ncbi.nlm.nih.gov/gene/2058 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006554 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA EXO1 http://www.ncbi.nlm.nih.gov/gene/9156 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006555 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA FAM105B http://www.ncbi.nlm.nih.gov/gene/90268 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006556 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA FAM161A http://www.ncbi.nlm.nih.gov/gene/84140 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006557 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA FAM177A1 http://www.ncbi.nlm.nih.gov/gene/283635 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006558 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA FAM179B http://www.ncbi.nlm.nih.gov/gene/23116 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006559 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA FAM82A2 http://www.ncbi.nlm.nih.gov/gene/55177 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006560 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA FANCF http://www.ncbi.nlm.nih.gov/gene/2188 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006561 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA FEM1B http://www.ncbi.nlm.nih.gov/gene/10116 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006562 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA FEM1C http://www.ncbi.nlm.nih.gov/gene/56929 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006563 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA FIGNL1 http://www.ncbi.nlm.nih.gov/gene/63979 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006564 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA FOXO1 http://www.ncbi.nlm.nih.gov/gene/2308 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006565 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA FOXO3 http://www.ncbi.nlm.nih.gov/gene/2310 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006566 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA FOXP2 http://www.ncbi.nlm.nih.gov/gene/93986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006567 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA G3BP2 http://www.ncbi.nlm.nih.gov/gene/9908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006568 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA GCNT2 http://www.ncbi.nlm.nih.gov/gene/2651 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006569 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA GFPT1 http://www.ncbi.nlm.nih.gov/gene/2673 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006570 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA GIT2 http://www.ncbi.nlm.nih.gov/gene/9815 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006571 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA GMPPB http://www.ncbi.nlm.nih.gov/gene/29925 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006572 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA GNA13 http://www.ncbi.nlm.nih.gov/gene/10672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006573 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA GNS http://www.ncbi.nlm.nih.gov/gene/2799 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006574 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA GOLGA5 http://www.ncbi.nlm.nih.gov/gene/9950 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006575 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA GRB2 http://www.ncbi.nlm.nih.gov/gene/2885 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006576 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA GRPEL2 http://www.ncbi.nlm.nih.gov/gene/134266 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006577 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA GSK3B http://www.ncbi.nlm.nih.gov/gene/2932 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006578 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA HACE1 http://www.ncbi.nlm.nih.gov/gene/57531 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006579 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA HACL1 http://www.ncbi.nlm.nih.gov/gene/26061 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006580 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA HAUS2 http://www.ncbi.nlm.nih.gov/gene/55142 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006581 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA HELLS http://www.ncbi.nlm.nih.gov/gene/3070 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006582 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA HELZ http://www.ncbi.nlm.nih.gov/gene/9931 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006583 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA HIATL1 http://www.ncbi.nlm.nih.gov/gene/84641 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006584 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA HMGCR http://www.ncbi.nlm.nih.gov/gene/3156 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006585 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA HNRNPA3 http://www.ncbi.nlm.nih.gov/gene/220988 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006586 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA HSPA13 http://www.ncbi.nlm.nih.gov/gene/6782 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006587 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA IKZF5 http://www.ncbi.nlm.nih.gov/gene/64376 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006588 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA IL1RAP http://www.ncbi.nlm.nih.gov/gene/3556 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006589 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA IMPA1 http://www.ncbi.nlm.nih.gov/gene/3612 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006590 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA IPO9 http://www.ncbi.nlm.nih.gov/gene/55705 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006591 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA IPPK http://www.ncbi.nlm.nih.gov/gene/64768 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006592 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA JHDM1D http://www.ncbi.nlm.nih.gov/gene/80853 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006593 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA KBTBD2 http://www.ncbi.nlm.nih.gov/gene/25948 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006594 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA KDM5C http://www.ncbi.nlm.nih.gov/gene/8242 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006595 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA KIAA1143 http://www.ncbi.nlm.nih.gov/gene/57456 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006596 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA KIAA1211 http://www.ncbi.nlm.nih.gov/gene/57482 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006597 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA KIAA1919 http://www.ncbi.nlm.nih.gov/gene/91749 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006598 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA KIF14 http://www.ncbi.nlm.nih.gov/gene/9928 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006599 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA KRIT1 http://www.ncbi.nlm.nih.gov/gene/889 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006600 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA LANCL1 http://www.ncbi.nlm.nih.gov/gene/10314 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006601 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA LCOR http://www.ncbi.nlm.nih.gov/gene/84458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006602 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA LIN9 http://www.ncbi.nlm.nih.gov/gene/286826 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006603 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA LONP2 http://www.ncbi.nlm.nih.gov/gene/83752 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006604 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA LPGAT1 http://www.ncbi.nlm.nih.gov/gene/9926 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006605 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA LRRC58 http://www.ncbi.nlm.nih.gov/gene/116064 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006606 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA LYRM7 http://www.ncbi.nlm.nih.gov/gene/90624 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006607 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MACROD2 http://www.ncbi.nlm.nih.gov/gene/140733 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006608 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MAP3K2 http://www.ncbi.nlm.nih.gov/gene/10746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006609 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MAPK6 http://www.ncbi.nlm.nih.gov/gene/5597 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006610 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MBNL2 http://www.ncbi.nlm.nih.gov/gene/10150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006611 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MBNL3 http://www.ncbi.nlm.nih.gov/gene/55796 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006612 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MBTD1 http://www.ncbi.nlm.nih.gov/gene/54799 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006613 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MCC http://www.ncbi.nlm.nih.gov/gene/4163 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006614 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MDN1 http://www.ncbi.nlm.nih.gov/gene/23195 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006615 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MEF2A http://www.ncbi.nlm.nih.gov/gene/4205 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006616 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MEX3B http://www.ncbi.nlm.nih.gov/gene/84206 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006617 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MEX3C http://www.ncbi.nlm.nih.gov/gene/51320 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006618 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MITF http://www.ncbi.nlm.nih.gov/gene/4286 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006619 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MLL5 http://www.ncbi.nlm.nih.gov/gene/55904 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006620 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MORC3 http://www.ncbi.nlm.nih.gov/gene/23515 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006621 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MRPL35 http://www.ncbi.nlm.nih.gov/gene/51318 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006622 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MRPS35 http://www.ncbi.nlm.nih.gov/gene/60488 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006623 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MSL2 http://www.ncbi.nlm.nih.gov/gene/55167 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006624 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MTHFD2 http://www.ncbi.nlm.nih.gov/gene/10797 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006625 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MTHFR http://www.ncbi.nlm.nih.gov/gene/4524 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006626 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MTMR9 http://www.ncbi.nlm.nih.gov/gene/66036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006627 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MTPN http://www.ncbi.nlm.nih.gov/gene/767558 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006628 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA MXD4 http://www.ncbi.nlm.nih.gov/gene/10608 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006629 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA NAB1 http://www.ncbi.nlm.nih.gov/gene/4664 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006630 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA NCAPG2 http://www.ncbi.nlm.nih.gov/gene/54892 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006631 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA NDUFA8 http://www.ncbi.nlm.nih.gov/gene/4702 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006632 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA NDUFC1 http://www.ncbi.nlm.nih.gov/gene/4717 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006633 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA NEK7 http://www.ncbi.nlm.nih.gov/gene/140609 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006634 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA NET1 http://www.ncbi.nlm.nih.gov/gene/10276 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006635 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA NFAT5 http://www.ncbi.nlm.nih.gov/gene/10725 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006636 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006637 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA NISCH http://www.ncbi.nlm.nih.gov/gene/11188 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006638 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA NPTN http://www.ncbi.nlm.nih.gov/gene/27020 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006639 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA NR3C1 http://www.ncbi.nlm.nih.gov/gene/2908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006640 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA NUCKS1 http://www.ncbi.nlm.nih.gov/gene/64710 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006641 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA NUP50 http://www.ncbi.nlm.nih.gov/gene/10762 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006642 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA NUPL1 http://www.ncbi.nlm.nih.gov/gene/9818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006643 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA OAS2 http://www.ncbi.nlm.nih.gov/gene/4939 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006644 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA OPTN http://www.ncbi.nlm.nih.gov/gene/10133 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006645 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ORC2L http://www.ncbi.nlm.nih.gov/gene/4999 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006646 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ORMDL3 http://www.ncbi.nlm.nih.gov/gene/94103 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006647 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA OSTM1 http://www.ncbi.nlm.nih.gov/gene/28962 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006648 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA OTUD6B http://www.ncbi.nlm.nih.gov/gene/51633 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006649 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA OXR1 http://www.ncbi.nlm.nih.gov/gene/55074 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006650 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PALM2-AKAP2 http://www.ncbi.nlm.nih.gov/gene/114299 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006651 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PAN3 http://www.ncbi.nlm.nih.gov/gene/255967 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006652 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PCDHB2 http://www.ncbi.nlm.nih.gov/gene/56133 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006653 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PCMTD2 http://www.ncbi.nlm.nih.gov/gene/55251 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006654 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PDCD4 http://www.ncbi.nlm.nih.gov/gene/27250 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006655 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PFTK1 http://www.ncbi.nlm.nih.gov/gene/5218 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006656 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PHACTR4 http://www.ncbi.nlm.nih.gov/gene/65979 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006657 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PHLPP2 http://www.ncbi.nlm.nih.gov/gene/23035 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006658 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PHTF2 http://www.ncbi.nlm.nih.gov/gene/57157 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006659 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PIAS4 http://www.ncbi.nlm.nih.gov/gene/51588 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006660 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PIGO http://www.ncbi.nlm.nih.gov/gene/84720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006661 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PIK3C2A http://www.ncbi.nlm.nih.gov/gene/5286 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006662 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PIP5K2B http://www.ncbi.nlm.nih.gov/gene/ 8396 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006663 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PLA2G6 http://www.ncbi.nlm.nih.gov/gene/8398 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006664 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PLEKHA2 http://www.ncbi.nlm.nih.gov/gene/59339 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006665 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA POGK http://www.ncbi.nlm.nih.gov/gene/57645 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006666 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA POLR3F http://www.ncbi.nlm.nih.gov/gene/10621 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006667 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA POU2F1 http://www.ncbi.nlm.nih.gov/gene/5451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006668 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PPHLN1 http://www.ncbi.nlm.nih.gov/gene/51535 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006669 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PPM1B http://www.ncbi.nlm.nih.gov/gene/5495 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006670 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PPP4R2 http://www.ncbi.nlm.nih.gov/gene/151987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006671 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PRDM1 http://www.ncbi.nlm.nih.gov/gene/639 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006672 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PREPL http://www.ncbi.nlm.nih.gov/gene/9581 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006673 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PRIM2 http://www.ncbi.nlm.nih.gov/gene/5558 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006674 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PRPF38A http://www.ncbi.nlm.nih.gov/gene/84950 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006675 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PTPLAD1 http://www.ncbi.nlm.nih.gov/gene/51495 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006676 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA PURB http://www.ncbi.nlm.nih.gov/gene/5814 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006677 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA QRICH1 http://www.ncbi.nlm.nih.gov/gene/54870 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006678 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA RAB11A http://www.ncbi.nlm.nih.gov/gene/8766 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006679 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA RAB11FIP2 http://www.ncbi.nlm.nih.gov/gene/22841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006680 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA RBM43 http://www.ncbi.nlm.nih.gov/gene/375287 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006681 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA RBM8A http://www.ncbi.nlm.nih.gov/gene/9939 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006682 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA RBPSUH http://www.ncbi.nlm.nih.gov/gene/3516 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006683 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA RCOR1 http://www.ncbi.nlm.nih.gov/gene/23186 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006684 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA RCOR3 http://www.ncbi.nlm.nih.gov/gene/55758 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006685 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA RHOU http://www.ncbi.nlm.nih.gov/gene/58480 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006686 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ROCK2 http://www.ncbi.nlm.nih.gov/gene/9475 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006687 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA RORA http://www.ncbi.nlm.nih.gov/gene/6095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006688 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA RPS6KA3 http://www.ncbi.nlm.nih.gov/gene/6197 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006689 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA RRAGC http://www.ncbi.nlm.nih.gov/gene/64121 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006690 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA RRM2B http://www.ncbi.nlm.nih.gov/gene/50484 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006691 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA RYBP http://www.ncbi.nlm.nih.gov/gene/23429 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006692 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA S100PBP http://www.ncbi.nlm.nih.gov/gene/64766 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006693 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SACM1L http://www.ncbi.nlm.nih.gov/gene/22908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006694 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SCD5 http://www.ncbi.nlm.nih.gov/gene/79966 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006695 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SDHD http://www.ncbi.nlm.nih.gov/gene/6392 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006696 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SETD6 http://www.ncbi.nlm.nih.gov/gene/79918 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006697 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SETD8 http://www.ncbi.nlm.nih.gov/gene/387893 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006698 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SFRS18 http://www.ncbi.nlm.nih.gov/gene/25957 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006699 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SH3BGRL2 http://www.ncbi.nlm.nih.gov/gene/83699 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006700 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SHCBP1 http://www.ncbi.nlm.nih.gov/gene/79801 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006701 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SIKE1 http://www.ncbi.nlm.nih.gov/gene/80143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006702 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SLBP http://www.ncbi.nlm.nih.gov/gene/7884 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006703 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SLC11A2 http://www.ncbi.nlm.nih.gov/gene/4891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006704 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SLC16A1 http://www.ncbi.nlm.nih.gov/gene/6566 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006705 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SLC9A1 http://www.ncbi.nlm.nih.gov/gene/6548 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006706 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SMAD2 http://www.ncbi.nlm.nih.gov/gene/4087 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006707 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SMAD4 http://www.ncbi.nlm.nih.gov/gene/4089 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006708 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SMAD5 http://www.ncbi.nlm.nih.gov/gene/4090 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006709 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SMC1A http://www.ncbi.nlm.nih.gov/gene/8243 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006710 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SMG1 http://www.ncbi.nlm.nih.gov/gene/23049 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006711 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SMURF2 http://www.ncbi.nlm.nih.gov/gene/64750 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006712 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SNTB2 http://www.ncbi.nlm.nih.gov/gene/6645 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006713 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SOS1 http://www.ncbi.nlm.nih.gov/gene/6654 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006714 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SPOPL http://www.ncbi.nlm.nih.gov/gene/339745 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006715 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SPTY2D1 http://www.ncbi.nlm.nih.gov/gene/144108 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006716 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SR140 http://www.ncbi.nlm.nih.gov/gene/23350 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006717 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SS18L1 http://www.ncbi.nlm.nih.gov/gene/26039 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006718 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA STAM2 http://www.ncbi.nlm.nih.gov/gene/10254 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006719 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA STRN http://www.ncbi.nlm.nih.gov/gene/6801 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006720 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA STYX http://www.ncbi.nlm.nih.gov/gene/6815 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006721 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA SYNCRIP http://www.ncbi.nlm.nih.gov/gene/10492 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006722 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA TAF4B http://www.ncbi.nlm.nih.gov/gene/6875 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006723 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA TAF8 http://www.ncbi.nlm.nih.gov/gene/129685 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006724 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA TFRC http://www.ncbi.nlm.nih.gov/gene/7037 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006725 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA TMEM188 http://www.ncbi.nlm.nih.gov/gene/100130176 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006726 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA TMEM20 http://www.ncbi.nlm.nih.gov/gene/159371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006727 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA TMEM209 http://www.ncbi.nlm.nih.gov/gene/84928 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006728 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA TPD52 http://www.ncbi.nlm.nih.gov/gene/7163 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006729 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA TRIM25 http://www.ncbi.nlm.nih.gov/gene/7706 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006730 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA TRIM26 http://www.ncbi.nlm.nih.gov/gene/7726 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006731 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA TRIM33 http://www.ncbi.nlm.nih.gov/gene/51592 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006732 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA TRIM65 http://www.ncbi.nlm.nih.gov/gene/201292 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006733 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA TSG101 http://www.ncbi.nlm.nih.gov/gene/7251 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006734 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA TTPAL http://www.ncbi.nlm.nih.gov/gene/79183 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006735 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA TXNDC16 http://www.ncbi.nlm.nih.gov/gene/57544 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006736 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA UBE2D3 http://www.ncbi.nlm.nih.gov/gene/100037280 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006737 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA UBN2 http://www.ncbi.nlm.nih.gov/gene/254048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006738 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA UBQLN1 http://www.ncbi.nlm.nih.gov/gene/29979 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006739 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA UBXN2A http://www.ncbi.nlm.nih.gov/gene/165324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006740 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA USP22 http://www.ncbi.nlm.nih.gov/gene/23326 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006741 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA UTP14C http://www.ncbi.nlm.nih.gov/gene/9724 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006742 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA VEZF1 http://www.ncbi.nlm.nih.gov/gene/7716 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006743 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA VEZT http://www.ncbi.nlm.nih.gov/gene/55591 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006744 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA VPS4B http://www.ncbi.nlm.nih.gov/gene/9525 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006745 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA WDR75 http://www.ncbi.nlm.nih.gov/gene/84128 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006746 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA WWTR1 http://www.ncbi.nlm.nih.gov/gene/25937 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006747 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA XPOT http://www.ncbi.nlm.nih.gov/gene/11260 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006748 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA XRCC4 http://www.ncbi.nlm.nih.gov/gene/7518 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006749 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA XRN2 http://www.ncbi.nlm.nih.gov/gene/22803 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006750 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA YTHDC1 http://www.ncbi.nlm.nih.gov/gene/91746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006751 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA YWHAB http://www.ncbi.nlm.nih.gov/gene/7529 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006752 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ZBTB33 http://www.ncbi.nlm.nih.gov/gene/10009 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006753 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ZBTB38 http://www.ncbi.nlm.nih.gov/gene/253461 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006754 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ZC3H11A http://www.ncbi.nlm.nih.gov/gene/9877 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006755 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ZFP36 http://www.ncbi.nlm.nih.gov/gene/7538 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006756 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ZFP90 http://www.ncbi.nlm.nih.gov/gene/146198 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006757 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ZFYVE20 http://www.ncbi.nlm.nih.gov/gene/64145 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006758 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ZNF12 http://www.ncbi.nlm.nih.gov/gene/7559 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006759 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ZNF28 http://www.ncbi.nlm.nih.gov/gene/7576 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006760 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ZNF302 http://www.ncbi.nlm.nih.gov/gene/55900 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006761 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ZNF320 http://www.ncbi.nlm.nih.gov/gene/162967 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006762 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ZNF326 http://www.ncbi.nlm.nih.gov/gene/284695 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006763 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ZNF451 http://www.ncbi.nlm.nih.gov/gene/26036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006764 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ZNF460 http://www.ncbi.nlm.nih.gov/gene/10794 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006765 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ZNF512B http://www.ncbi.nlm.nih.gov/gene/57473 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006766 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ZNF655 http://www.ncbi.nlm.nih.gov/gene/79027 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006767 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ZNF714 http://www.ncbi.nlm.nih.gov/gene/148206 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006768 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ZNF738 http://www.ncbi.nlm.nih.gov/gene/148203 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006769 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-1 - Host mRNA ZNF772 http://www.ncbi.nlm.nih.gov/gene/400720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006770 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ABHD3 http://www.ncbi.nlm.nih.gov/gene/171586 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006771 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ABL2 http://www.ncbi.nlm.nih.gov/gene/27 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006772 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ADIPOR2 http://www.ncbi.nlm.nih.gov/gene/79602 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006773 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ANKMY2 http://www.ncbi.nlm.nih.gov/gene/57037 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006774 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA APP http://www.ncbi.nlm.nih.gov/gene/351 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006775 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA APTX http://www.ncbi.nlm.nih.gov/gene/54840 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006776 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ARFGEF1 http://www.ncbi.nlm.nih.gov/gene/10565 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006777 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ARL5B http://www.ncbi.nlm.nih.gov/gene/221079 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006778 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ARL6IP1 http://www.ncbi.nlm.nih.gov/gene/23204 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006779 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ASZ1 http://www.ncbi.nlm.nih.gov/gene/136991 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006780 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ATE1 http://www.ncbi.nlm.nih.gov/gene/11101 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006781 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ATP6V0E1 http://www.ncbi.nlm.nih.gov/gene/8992 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006782 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ATP6V1A http://www.ncbi.nlm.nih.gov/gene/523 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006783 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA BBX http://www.ncbi.nlm.nih.gov/gene/56987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006784 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA BCL2L2 http://www.ncbi.nlm.nih.gov/gene/599 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006785 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA BTBD3 http://www.ncbi.nlm.nih.gov/gene/22903 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006786 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA C14orf2 http://www.ncbi.nlm.nih.gov/gene/9556 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006787 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA C16orf80 http://www.ncbi.nlm.nih.gov/gene/29105 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006788 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA C20orf112 http://www.ncbi.nlm.nih.gov/gene/140688 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006789 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA C5orf24 http://www.ncbi.nlm.nih.gov/gene/134553 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006790 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA C7orf42 http://www.ncbi.nlm.nih.gov/gene/55069 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006791 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA C9orf126 http://www.ncbi.nlm.nih.gov/gene/286205 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006792 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA CAMKK2 http://www.ncbi.nlm.nih.gov/gene/10645 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006793 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA CARD8 http://www.ncbi.nlm.nih.gov/gene/22900 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006794 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA CCDC50 http://www.ncbi.nlm.nih.gov/gene/152137 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006795 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA CCNG1 http://www.ncbi.nlm.nih.gov/gene/900 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006796 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006797 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA CD59 http://www.ncbi.nlm.nih.gov/gene/966 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006798 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA CDC2L5 http://www.ncbi.nlm.nih.gov/gene/8621 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006799 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA CDC42SE1 http://www.ncbi.nlm.nih.gov/gene/56882 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006800 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA CDCA8 http://www.ncbi.nlm.nih.gov/gene/55143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006801 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA CDR2 http://www.ncbi.nlm.nih.gov/gene/1039 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006802 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA CETN3 http://www.ncbi.nlm.nih.gov/gene/1070 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006803 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA CFL2 http://www.ncbi.nlm.nih.gov/gene/1073 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006804 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA CITED2 http://www.ncbi.nlm.nih.gov/gene/10370 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006805 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA CLP1 http://www.ncbi.nlm.nih.gov/gene/10978 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006806 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA COBLL1 http://www.ncbi.nlm.nih.gov/gene/22837 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006807 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA COCH http://www.ncbi.nlm.nih.gov/gene/1690 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006808 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA CPD http://www.ncbi.nlm.nih.gov/gene/1362 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006809 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA CPEB3 http://www.ncbi.nlm.nih.gov/gene/22849 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006810 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA CXorf39 http://www.ncbi.nlm.nih.gov/gene/139231 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006811 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA DDI2 http://www.ncbi.nlm.nih.gov/gene/84301 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006812 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA DDX21 http://www.ncbi.nlm.nih.gov/gene/9188 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006813 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA DHX40 http://www.ncbi.nlm.nih.gov/gene/100134387 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006814 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA DIDO1 http://www.ncbi.nlm.nih.gov/gene/11083 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006815 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA DLG1 http://www.ncbi.nlm.nih.gov/gene/1739 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006816 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA DNAJB4 http://www.ncbi.nlm.nih.gov/gene/11080 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006817 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA DNAJB9 http://www.ncbi.nlm.nih.gov/gene/4189 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006818 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA DNM2 http://www.ncbi.nlm.nih.gov/gene/1785 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006819 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA DYNC1LI1 http://www.ncbi.nlm.nih.gov/gene/51143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006820 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA E2F7 http://www.ncbi.nlm.nih.gov/gene/144455 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006821 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA EAF1 http://www.ncbi.nlm.nih.gov/gene/85403 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006822 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA EPDR1 http://www.ncbi.nlm.nih.gov/gene/54749 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006823 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ESD http://www.ncbi.nlm.nih.gov/gene/2098 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006824 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA EXO1 http://www.ncbi.nlm.nih.gov/gene/9156 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006825 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA EXOC5 http://www.ncbi.nlm.nih.gov/gene/10640 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006826 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA EZH2 http://www.ncbi.nlm.nih.gov/gene/2146 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006827 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA FAM105B http://www.ncbi.nlm.nih.gov/gene/90268 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006828 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA FAM171B http://www.ncbi.nlm.nih.gov/gene/165215 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006829 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA FAM82A2 http://www.ncbi.nlm.nih.gov/gene/55177 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006830 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA FANCF http://www.ncbi.nlm.nih.gov/gene/2188 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006831 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA FOXN3 http://www.ncbi.nlm.nih.gov/gene/1112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006832 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA FOXO1 http://www.ncbi.nlm.nih.gov/gene/2308 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006833 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA FOXO3 http://www.ncbi.nlm.nih.gov/gene/2310 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006834 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA FOXP2 http://www.ncbi.nlm.nih.gov/gene/93986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006835 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA FZD10 http://www.ncbi.nlm.nih.gov/gene/11211 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006836 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA G3BP2 http://www.ncbi.nlm.nih.gov/gene/9908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006837 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA GART http://www.ncbi.nlm.nih.gov/gene/2618 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006838 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA GCNT2 http://www.ncbi.nlm.nih.gov/gene/2651 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006839 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA GDAP1 http://www.ncbi.nlm.nih.gov/gene/54332 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006840 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA GFPT1 http://www.ncbi.nlm.nih.gov/gene/2673 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006841 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA GIT2 http://www.ncbi.nlm.nih.gov/gene/9815 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006842 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA GLS http://www.ncbi.nlm.nih.gov/gene/2744 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006843 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA GMFB http://www.ncbi.nlm.nih.gov/gene/2764 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006844 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA GMPPB http://www.ncbi.nlm.nih.gov/gene/29925 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006845 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA GNA13 http://www.ncbi.nlm.nih.gov/gene/10672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006846 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA GOLGA5 http://www.ncbi.nlm.nih.gov/gene/9950 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006847 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA GORASP2 http://www.ncbi.nlm.nih.gov/gene/26003 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006848 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA GRB2 http://www.ncbi.nlm.nih.gov/gene/2885 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006849 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA GRPEL2 http://www.ncbi.nlm.nih.gov/gene/134266 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006850 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA HACE1 http://www.ncbi.nlm.nih.gov/gene/57531 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006851 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA HACL1 http://www.ncbi.nlm.nih.gov/gene/26061 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006852 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA HELLS http://www.ncbi.nlm.nih.gov/gene/3070 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006853 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA HIATL1 http://www.ncbi.nlm.nih.gov/gene/84641 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006854 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA HMCN1 http://www.ncbi.nlm.nih.gov/gene/83872 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006855 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA HSPA13 http://www.ncbi.nlm.nih.gov/gene/6782 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006856 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA HSPA9 http://www.ncbi.nlm.nih.gov/gene/3313 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006857 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ICMT http://www.ncbi.nlm.nih.gov/gene/23463 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006858 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA IDH3A http://www.ncbi.nlm.nih.gov/gene/3419 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006859 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA IGF2BP3 http://www.ncbi.nlm.nih.gov/gene/10643 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006860 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA IKZF5 http://www.ncbi.nlm.nih.gov/gene/64376 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006861 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA IMPA1 http://www.ncbi.nlm.nih.gov/gene/3612 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006862 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA INPP4A http://www.ncbi.nlm.nih.gov/gene/3631 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006863 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA IPO7 http://www.ncbi.nlm.nih.gov/gene/10527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006864 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA IPO9 http://www.ncbi.nlm.nih.gov/gene/55705 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006865 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA IPPK http://www.ncbi.nlm.nih.gov/gene/64768 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006866 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA KBTBD11 http://www.ncbi.nlm.nih.gov/gene/9920 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006867 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA KBTBD2 http://www.ncbi.nlm.nih.gov/gene/25948 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006868 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA KIAA1143 http://www.ncbi.nlm.nih.gov/gene/57456 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006869 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA KIAA1211 http://www.ncbi.nlm.nih.gov/gene/57482 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006870 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA KIAA1462 http://www.ncbi.nlm.nih.gov/gene/57608 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006871 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA KIAA1712 http://www.ncbi.nlm.nih.gov/gene/80817 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006872 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA KLHL13 http://www.ncbi.nlm.nih.gov/gene/90293 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006873 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA KLHL21 http://www.ncbi.nlm.nih.gov/gene/9903 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006874 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA KRIT1 http://www.ncbi.nlm.nih.gov/gene/889 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006875 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA LANCL1 http://www.ncbi.nlm.nih.gov/gene/10314 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006876 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA LCOR http://www.ncbi.nlm.nih.gov/gene/84458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006877 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA LDLRAP1 http://www.ncbi.nlm.nih.gov/gene/26119 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006878 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA LIG4 http://www.ncbi.nlm.nih.gov/gene/3981 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006879 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA LIN9 http://www.ncbi.nlm.nih.gov/gene/286826 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006880 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA LMO4 http://www.ncbi.nlm.nih.gov/gene/8543 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006881 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA LNX2 http://www.ncbi.nlm.nih.gov/gene/222484 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006882 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA LONP2 http://www.ncbi.nlm.nih.gov/gene/83752 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006883 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA LRP12 http://www.ncbi.nlm.nih.gov/gene/29967 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006884 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA LRRC58 http://www.ncbi.nlm.nih.gov/gene/116064 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006885 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA MAP2K1 http://www.ncbi.nlm.nih.gov/gene/5604 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006886 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA MAP3K1 http://www.ncbi.nlm.nih.gov/gene/4214 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006887 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA MAP7D2 http://www.ncbi.nlm.nih.gov/gene/256714 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006888 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA MAPK1 http://www.ncbi.nlm.nih.gov/gene/5594 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006889 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA MAPK6 http://www.ncbi.nlm.nih.gov/gene/5597 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006890 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA MCC http://www.ncbi.nlm.nih.gov/gene/4163 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006891 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA MEF2D http://www.ncbi.nlm.nih.gov/gene/4209 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006892 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA MGST1 http://www.ncbi.nlm.nih.gov/gene/4257 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006893 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA MLL5 http://www.ncbi.nlm.nih.gov/gene/55904 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006894 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA MORC3 http://www.ncbi.nlm.nih.gov/gene/23515 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006895 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA MPZ http://www.ncbi.nlm.nih.gov/gene/4359 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006896 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA MRPL35 http://www.ncbi.nlm.nih.gov/gene/51318 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006897 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA MTHFD2 http://www.ncbi.nlm.nih.gov/gene/10797 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006898 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA MTMR9 http://www.ncbi.nlm.nih.gov/gene/66036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006899 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA MTPN http://www.ncbi.nlm.nih.gov/gene/767558 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006900 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA MXD4 http://www.ncbi.nlm.nih.gov/gene/10608 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006901 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA NAB1 http://www.ncbi.nlm.nih.gov/gene/4664 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006902 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA NARS http://www.ncbi.nlm.nih.gov/gene/4677 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006903 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA NCAPG2 http://www.ncbi.nlm.nih.gov/gene/54892 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006904 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA NDE1 http://www.ncbi.nlm.nih.gov/gene/54820 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006905 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA NDUFA8 http://www.ncbi.nlm.nih.gov/gene/4702 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006906 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA NDUFC1 http://www.ncbi.nlm.nih.gov/gene/4717 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006907 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA NET1 http://www.ncbi.nlm.nih.gov/gene/10276 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006908 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA NFAT5 http://www.ncbi.nlm.nih.gov/gene/10725 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006909 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006910 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA NFXL1 http://www.ncbi.nlm.nih.gov/gene/152518 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006911 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA NISCH http://www.ncbi.nlm.nih.gov/gene/11188 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006912 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA NKD1 http://www.ncbi.nlm.nih.gov/gene/85407 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006913 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA NR3C1 http://www.ncbi.nlm.nih.gov/gene/2908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006914 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA NUCKS1 http://www.ncbi.nlm.nih.gov/gene/64710 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006915 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA NUDCD2 http://www.ncbi.nlm.nih.gov/gene/134492 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006916 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA NUP35 http://www.ncbi.nlm.nih.gov/gene/129401 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006917 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA NUSAP1 http://www.ncbi.nlm.nih.gov/gene/51203 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006918 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA OAS2 http://www.ncbi.nlm.nih.gov/gene/4939 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006919 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ORC2L http://www.ncbi.nlm.nih.gov/gene/4999 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006920 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA OSTM1 http://www.ncbi.nlm.nih.gov/gene/28962 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006921 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PABPC4L http://www.ncbi.nlm.nih.gov/gene/132430 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006922 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PACRGL http://www.ncbi.nlm.nih.gov/gene/133015 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006923 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PAK6 http://www.ncbi.nlm.nih.gov/gene/56924 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006924 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PALM2-AKAP2 http://www.ncbi.nlm.nih.gov/gene/114299 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006925 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PAN3 http://www.ncbi.nlm.nih.gov/gene/255967 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006926 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PDCD4 http://www.ncbi.nlm.nih.gov/gene/27250 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006927 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PGAP1 http://www.ncbi.nlm.nih.gov/gene/80055 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006928 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PHACTR4 http://www.ncbi.nlm.nih.gov/gene/65979 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006929 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PHLPP2 http://www.ncbi.nlm.nih.gov/gene/23035 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006930 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PIAS4 http://www.ncbi.nlm.nih.gov/gene/51588 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006931 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PIGA http://www.ncbi.nlm.nih.gov/gene/5277 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006932 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PIGO http://www.ncbi.nlm.nih.gov/gene/84720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006933 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PIP5K2B http://www.ncbi.nlm.nih.gov/gene/ 8396 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006934 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PLEKHA2 http://www.ncbi.nlm.nih.gov/gene/59339 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006935 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PLS3 http://www.ncbi.nlm.nih.gov/gene/5358 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006936 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PNKD http://www.ncbi.nlm.nih.gov/gene/25953 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006937 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA POLR3F http://www.ncbi.nlm.nih.gov/gene/10621 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006938 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PPHLN1 http://www.ncbi.nlm.nih.gov/gene/51535 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006939 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PPM1B http://www.ncbi.nlm.nih.gov/gene/5495 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006940 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PRDM1 http://www.ncbi.nlm.nih.gov/gene/639 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006941 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PRPF38A http://www.ncbi.nlm.nih.gov/gene/84950 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006942 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PSEN1 http://www.ncbi.nlm.nih.gov/gene/5663 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006943 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PSMD11 http://www.ncbi.nlm.nih.gov/gene/5717 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006944 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PSME4 http://www.ncbi.nlm.nih.gov/gene/23198 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006945 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PTPLAD1 http://www.ncbi.nlm.nih.gov/gene/51495 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006946 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA PTPLAD2 http://www.ncbi.nlm.nih.gov/gene/401494 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006947 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA QRICH1 http://www.ncbi.nlm.nih.gov/gene/54870 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006948 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA RAB11A http://www.ncbi.nlm.nih.gov/gene/8766 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006949 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA RAB11FIP2 http://www.ncbi.nlm.nih.gov/gene/22841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006950 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA RARB http://www.ncbi.nlm.nih.gov/gene/5915 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006951 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA RBL1 http://www.ncbi.nlm.nih.gov/gene/5933 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006952 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA RBM8A http://www.ncbi.nlm.nih.gov/gene/9939 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006953 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA RBPSUH http://www.ncbi.nlm.nih.gov/gene/3516 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006954 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA RIF1 http://www.ncbi.nlm.nih.gov/gene/55183 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006955 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ROCK2 http://www.ncbi.nlm.nih.gov/gene/9475 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006956 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA RRM2B http://www.ncbi.nlm.nih.gov/gene/50484 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006957 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA RUFY2 http://www.ncbi.nlm.nih.gov/gene/55680 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006958 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA S100PBP http://www.ncbi.nlm.nih.gov/gene/64766 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006959 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA SCAMP1 http://www.ncbi.nlm.nih.gov/gene/9522 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006960 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA SDHD http://www.ncbi.nlm.nih.gov/gene/6392 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006961 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA SDR42E1 http://www.ncbi.nlm.nih.gov/gene/93517 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006962 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA SEC61A1 http://www.ncbi.nlm.nih.gov/gene/29927 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006963 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA SERTAD2 http://www.ncbi.nlm.nih.gov/gene/9792 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006964 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA SETD6 http://www.ncbi.nlm.nih.gov/gene/79918 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006965 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA SFRS18 http://www.ncbi.nlm.nih.gov/gene/25957 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006966 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA SH3BGRL2 http://www.ncbi.nlm.nih.gov/gene/83699 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006967 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA SIAE http://www.ncbi.nlm.nih.gov/gene/54414 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006968 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA SIKE1 http://www.ncbi.nlm.nih.gov/gene/80143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006969 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA SLBP http://www.ncbi.nlm.nih.gov/gene/7884 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006970 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA SMAD4 http://www.ncbi.nlm.nih.gov/gene/4089 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006971 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA SMC1A http://www.ncbi.nlm.nih.gov/gene/8243 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006972 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA SPOPL http://www.ncbi.nlm.nih.gov/gene/339745 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006973 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA SPTY2D1 http://www.ncbi.nlm.nih.gov/gene/144108 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006974 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA STAM2 http://www.ncbi.nlm.nih.gov/gene/10254 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006975 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA STYX http://www.ncbi.nlm.nih.gov/gene/6815 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006976 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA SUPT6H http://www.ncbi.nlm.nih.gov/gene/6830 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006977 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA SYNCRIP http://www.ncbi.nlm.nih.gov/gene/10492 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006978 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA TAF4B http://www.ncbi.nlm.nih.gov/gene/6875 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006979 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA TES http://www.ncbi.nlm.nih.gov/gene/26136 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006980 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA THOC5 http://www.ncbi.nlm.nih.gov/gene/8563 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006981 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA TJP1 http://www.ncbi.nlm.nih.gov/gene/7082 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006982 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA TNKS http://www.ncbi.nlm.nih.gov/gene/8658 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006983 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA TRAPPC2 http://www.ncbi.nlm.nih.gov/gene/6399 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006984 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA TRIM26 http://www.ncbi.nlm.nih.gov/gene/7726 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006985 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA TRIM33 http://www.ncbi.nlm.nih.gov/gene/51592 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006986 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA TRIM65 http://www.ncbi.nlm.nih.gov/gene/201292 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006987 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA TSG101 http://www.ncbi.nlm.nih.gov/gene/7251 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006988 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA TWISTNB http://www.ncbi.nlm.nih.gov/gene/221830 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006989 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA TXNDC16 http://www.ncbi.nlm.nih.gov/gene/57544 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006990 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA UBE2D3 http://www.ncbi.nlm.nih.gov/gene/100037280 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006991 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA UBN2 http://www.ncbi.nlm.nih.gov/gene/254048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006992 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA UBQLN1 http://www.ncbi.nlm.nih.gov/gene/29979 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006993 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA UTP14C http://www.ncbi.nlm.nih.gov/gene/9724 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006994 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA VASH2 http://www.ncbi.nlm.nih.gov/gene/79805 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006995 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA VEZT http://www.ncbi.nlm.nih.gov/gene/55591 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006996 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA VPS4B http://www.ncbi.nlm.nih.gov/gene/9525 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006997 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA WDFY3 http://www.ncbi.nlm.nih.gov/gene/23001 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006998 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA XPOT http://www.ncbi.nlm.nih.gov/gene/11260 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00006999 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA XRCC4 http://www.ncbi.nlm.nih.gov/gene/7518 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007000 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA XRN2 http://www.ncbi.nlm.nih.gov/gene/22803 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007001 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ZBTB33 http://www.ncbi.nlm.nih.gov/gene/10009 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007002 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ZBTB38 http://www.ncbi.nlm.nih.gov/gene/253461 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007003 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ZC3H12C http://www.ncbi.nlm.nih.gov/gene/85463 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007004 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ZFP36 http://www.ncbi.nlm.nih.gov/gene/7538 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007005 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ZFP90 http://www.ncbi.nlm.nih.gov/gene/146198 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007006 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ZNF12 http://www.ncbi.nlm.nih.gov/gene/7559 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007007 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ZNF215 http://www.ncbi.nlm.nih.gov/gene/7762 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007008 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ZNF28 http://www.ncbi.nlm.nih.gov/gene/7576 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007009 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ZNF320 http://www.ncbi.nlm.nih.gov/gene/162967 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007010 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ZNF35 http://www.ncbi.nlm.nih.gov/gene/7584 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007011 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ZNF382 http://www.ncbi.nlm.nih.gov/gene/84911 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007012 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ZNF512B http://www.ncbi.nlm.nih.gov/gene/57473 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007013 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ZNF655 http://www.ncbi.nlm.nih.gov/gene/79027 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007014 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ZNF682 http://www.ncbi.nlm.nih.gov/gene/91120 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007015 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ZNF717 http://www.ncbi.nlm.nih.gov/gene/100131827 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007016 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ZNF738 http://www.ncbi.nlm.nih.gov/gene/148203 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007017 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ZNF750 http://www.ncbi.nlm.nih.gov/gene/79755 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007018 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BC-3 - Host mRNA ZNF772 http://www.ncbi.nlm.nih.gov/gene/400720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007019 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA ABL2 http://www.ncbi.nlm.nih.gov/gene/27 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells.Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007020 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA APTX http://www.ncbi.nlm.nih.gov/gene/54840 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007021 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA ARIH1 http://www.ncbi.nlm.nih.gov/gene/25820 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007022 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA BBX http://www.ncbi.nlm.nih.gov/gene/56987 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007023 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA BICD2 http://www.ncbi.nlm.nih.gov/gene/23299 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007024 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA BTAF1 http://www.ncbi.nlm.nih.gov/gene/9044 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007025 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA CASP3 http://www.ncbi.nlm.nih.gov/gene/836 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007026 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA CD59 http://www.ncbi.nlm.nih.gov/gene/966 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007027 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA CDC2L5 http://www.ncbi.nlm.nih.gov/gene/8621 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells.Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007028 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA CDCA8 http://www.ncbi.nlm.nih.gov/gene/55143 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007029 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA CDR2 http://www.ncbi.nlm.nih.gov/gene/1039 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007030 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA CFL2 http://www.ncbi.nlm.nih.gov/gene/1073 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007031 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA CHIC2 http://www.ncbi.nlm.nih.gov/gene/26511 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007032 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA DDX21 http://www.ncbi.nlm.nih.gov/gene/9188 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells.Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007033 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA DNM2 http://www.ncbi.nlm.nih.gov/gene/1785 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells.Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007034 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA E2F7 http://www.ncbi.nlm.nih.gov/gene/144455 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007035 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA EAF1 http://www.ncbi.nlm.nih.gov/gene/85403 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007036 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA FIGNL1 http://www.ncbi.nlm.nih.gov/gene/63979 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007037 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA GART http://www.ncbi.nlm.nih.gov/gene/2618 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007038 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA GCNT2 http://www.ncbi.nlm.nih.gov/gene/2651 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007039 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA GFPT1 http://www.ncbi.nlm.nih.gov/gene/2673 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007040 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA GNS http://www.ncbi.nlm.nih.gov/gene/2799 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007041 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA GOLGA5 http://www.ncbi.nlm.nih.gov/gene/9950 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells.Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007042 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA GRB2 http://www.ncbi.nlm.nih.gov/gene/2885 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells.Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007043 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA IPO9 http://www.ncbi.nlm.nih.gov/gene/55705 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells.Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007044 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA KBTBD2 http://www.ncbi.nlm.nih.gov/gene/25948 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells.Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007045 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA LMO4 http://www.ncbi.nlm.nih.gov/gene/8543 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007046 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA LNX2 http://www.ncbi.nlm.nih.gov/gene/222484 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007047 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA MAPK6 http://www.ncbi.nlm.nih.gov/gene/5597 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007048 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA MBTD1 http://www.ncbi.nlm.nih.gov/gene/54799 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007049 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA MPZ http://www.ncbi.nlm.nih.gov/gene/4359 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007050 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA NDE1 http://www.ncbi.nlm.nih.gov/gene/54820 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007051 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA NDUFA8 http://www.ncbi.nlm.nih.gov/gene/4702 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007052 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA NISCH http://www.ncbi.nlm.nih.gov/gene/11188 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells.Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007053 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA NR3C1 http://www.ncbi.nlm.nih.gov/gene/2908 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells.Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007054 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA PFTK1 http://www.ncbi.nlm.nih.gov/gene/5218 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007055 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA PHTF2 http://www.ncbi.nlm.nih.gov/gene/57157 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007056 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA PIP5K2B http://www.ncbi.nlm.nih.gov/gene/ 8396 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells.Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007057 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA PLEKHA2 http://www.ncbi.nlm.nih.gov/gene/59339 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells.Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007058 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA PPHLN1 http://www.ncbi.nlm.nih.gov/gene/51535 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007059 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA PRDM1 http://www.ncbi.nlm.nih.gov/gene/639 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells.Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007060 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA PSEN1 http://www.ncbi.nlm.nih.gov/gene/5663 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007061 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA PSME4 http://www.ncbi.nlm.nih.gov/gene/23198 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007062 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA RBL1 http://www.ncbi.nlm.nih.gov/gene/5933 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007063 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA RBM8A http://www.ncbi.nlm.nih.gov/gene/9939 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells.Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007064 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA RCOR3 http://www.ncbi.nlm.nih.gov/gene/55758 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007065 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA ROCK2 http://www.ncbi.nlm.nih.gov/gene/9475 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007066 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA SLBP http://www.ncbi.nlm.nih.gov/gene/7884 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells.Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007067 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA SNTB2 http://www.ncbi.nlm.nih.gov/gene/6645 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007068 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA STRN http://www.ncbi.nlm.nih.gov/gene/6801 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007069 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA SUPT6H http://www.ncbi.nlm.nih.gov/gene/6830 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007070 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA TES http://www.ncbi.nlm.nih.gov/gene/26136 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007071 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA TPD52 http://www.ncbi.nlm.nih.gov/gene/7163 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007072 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA TRIM25 http://www.ncbi.nlm.nih.gov/gene/7706 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007073 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA TRIM33 http://www.ncbi.nlm.nih.gov/gene/51592 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells.Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007074 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA XPOT http://www.ncbi.nlm.nih.gov/gene/11260 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells.Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007075 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA XRN2 http://www.ncbi.nlm.nih.gov/gene/22803 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells.Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007076 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA YWHAB http://www.ncbi.nlm.nih.gov/gene/7529 - PAR-CLIP. 22100165 Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007077 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 BJAB/miR-K4-3p cells - Host mRNA ZFP90 http://www.ncbi.nlm.nih.gov/gene/146198 - PAR-CLIP. 22100165 Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells. VHID00007078 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC3 - Host mRNA Bach1 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00007079 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BCBL1 - Host mRNA Bach1 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00007080 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BCBL1 - Host mRNA NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00007081 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BCBL1 - Host mRNA RBL2 http://www.ncbi.nlm.nih.gov/gene/5934 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00007082 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K12-4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 - - Host Protein DNMT1 http://www.ncbi.nlm.nih.gov/gene/5934 Upregulation ChIP and KSHV genome array, Quantitative RT-PCR, MeDIP, Luciferase assay. 20071580 Viral miRNA, K12-4-5p, was found to have a sequence targeting retinoblastoma (Rb)-like protein 2 (Rbl2), which is a known repressor of DNA methyl transferase 3a and 3b mRNA transcription. We show that ectopic expression of miR-K12-4-5p reduces Rbl2 protein expression and increases DNMT1, -3a, and -3b mRNA levels relative to the levels for control cells. VHID00007083 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K12-4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 - - Host Protein RBL2 http://www.ncbi.nlm.nih.gov/gene/5934 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00007084 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K12-4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 - - Host Protein RBL2(Rbl2) http://www.ncbi.nlm.nih.gov/gene/5934 Downregulation Quantitative RT-PCR, Luciferase assay, Infection, Reconstitution of recombinant virus, ChIP and KSHV genome array, MeDIP, Genome copy number assay. 20071580 One viral miRNA, K12-4-5p, was found to have a sequence targeting retinoblastoma (Rb)-like protein 2 (Rbl2), which is a known repressor of DNA methyl transferase 3a and 3b mRNA transcription. We show that ectopic expression of miR-K12-4-5p reduces Rbl2 protein expression and increases DNMT1, -3a, and -3b mRNA levels relative to the levels for control cells. VHID00007085 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K12-4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 - - Host mRNA RBL2 http://www.ncbi.nlm.nih.gov/gene/5934 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00007086 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA ABCE1 http://www.ncbi.nlm.nih.gov/gene/647150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007087 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA ABHD2 http://www.ncbi.nlm.nih.gov/gene/11057 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007088 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA ABLIM1 http://www.ncbi.nlm.nih.gov/gene/3983 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007089 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA ABT1 http://www.ncbi.nlm.nih.gov/gene/29777 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007090 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA ACBD3 http://www.ncbi.nlm.nih.gov/gene/64746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007091 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA AFF4 http://www.ncbi.nlm.nih.gov/gene/27125 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007092 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA AIMP1 http://www.ncbi.nlm.nih.gov/gene/9255 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007093 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA ANLN http://www.ncbi.nlm.nih.gov/gene/54443 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007094 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA AP3M2 http://www.ncbi.nlm.nih.gov/gene/10947 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007095 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA ARFGEF1 http://www.ncbi.nlm.nih.gov/gene/10565 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007096 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA ARL5B http://www.ncbi.nlm.nih.gov/gene/221079 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007097 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA BACH1 http://www.ncbi.nlm.nih.gov/gene/571 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007098 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA BAZ1B http://www.ncbi.nlm.nih.gov/gene/9031 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007099 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA BBX http://www.ncbi.nlm.nih.gov/gene/56987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007100 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA BCL2 http://www.ncbi.nlm.nih.gov/gene/596 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007101 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA BCL7B http://www.ncbi.nlm.nih.gov/gene/9275 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007102 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA BRWD1 http://www.ncbi.nlm.nih.gov/gene/54014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007103 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA BTBD1 http://www.ncbi.nlm.nih.gov/gene/53339 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007104 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA C4orf46 http://www.ncbi.nlm.nih.gov/gene/201725 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007105 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA C7orf60 http://www.ncbi.nlm.nih.gov/gene/154743 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007106 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA CALM2 http://www.ncbi.nlm.nih.gov/gene/808 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007107 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA CCDC93 http://www.ncbi.nlm.nih.gov/gene/54520 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007108 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007109 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA CDC23 http://www.ncbi.nlm.nih.gov/gene/8697 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007110 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA CLCN5 http://www.ncbi.nlm.nih.gov/gene/1184 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007111 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA COG5 http://www.ncbi.nlm.nih.gov/gene/10466 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007112 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA COX11 http://www.ncbi.nlm.nih.gov/gene/1353 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007113 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA CPEB2 http://www.ncbi.nlm.nih.gov/gene/132864 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007114 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA CPEB4 http://www.ncbi.nlm.nih.gov/gene/80315 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007115 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA CPSF6 http://www.ncbi.nlm.nih.gov/gene/11052 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007116 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA CREBZF http://www.ncbi.nlm.nih.gov/gene/58487 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007117 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA CSRNP2 http://www.ncbi.nlm.nih.gov/gene/81566 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007118 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA CUX1 http://www.ncbi.nlm.nih.gov/gene/1523 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007119 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA DENND5B http://www.ncbi.nlm.nih.gov/gene/160518 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007120 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA DPY19L1 http://www.ncbi.nlm.nih.gov/gene/23333 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007121 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA DSTYK http://www.ncbi.nlm.nih.gov/gene/25778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007122 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA E2F3 http://www.ncbi.nlm.nih.gov/gene/1871 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007123 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA EIF4G3 http://www.ncbi.nlm.nih.gov/gene/8672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007124 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA FBXO11 http://www.ncbi.nlm.nih.gov/gene/80204 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007125 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA FOXN2 http://www.ncbi.nlm.nih.gov/gene/3344 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007126 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA FRS2 http://www.ncbi.nlm.nih.gov/gene/10818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007127 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA FSTL5 http://www.ncbi.nlm.nih.gov/gene/56884 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007128 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA FZD6 http://www.ncbi.nlm.nih.gov/gene/8323 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007129 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA G2E3 http://www.ncbi.nlm.nih.gov/gene/55632 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007130 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA GAB1 http://www.ncbi.nlm.nih.gov/gene/2549 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007131 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA GNL3L http://www.ncbi.nlm.nih.gov/gene/54552 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007132 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA HACE1 http://www.ncbi.nlm.nih.gov/gene/57531 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007133 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA HIAT1 http://www.ncbi.nlm.nih.gov/gene/64645 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007134 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA IGF2R http://www.ncbi.nlm.nih.gov/gene/3482 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007135 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA IQGAP1 http://www.ncbi.nlm.nih.gov/gene/8826 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007136 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA IRF2BP2 http://www.ncbi.nlm.nih.gov/gene/359948 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007137 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA KRCC1 http://www.ncbi.nlm.nih.gov/gene/51315 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007138 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA L2HGDH http://www.ncbi.nlm.nih.gov/gene/79944 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007139 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA LARP4 http://www.ncbi.nlm.nih.gov/gene/113251 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007140 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA LIMA1 http://www.ncbi.nlm.nih.gov/gene/51474 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007141 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA LIN28B http://www.ncbi.nlm.nih.gov/gene/389421 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007142 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA LRRC59 http://www.ncbi.nlm.nih.gov/gene/55379 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007143 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA MED17 http://www.ncbi.nlm.nih.gov/gene/9440 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007144 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA MIER3 http://www.ncbi.nlm.nih.gov/gene/166968 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007145 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA MKRN3 http://www.ncbi.nlm.nih.gov/gene/7681 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007146 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA MPP5 http://www.ncbi.nlm.nih.gov/gene/64398 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007147 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA MRPS35 http://www.ncbi.nlm.nih.gov/gene/60488 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007148 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA MXI1 http://www.ncbi.nlm.nih.gov/gene/4601 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007149 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA NFAT5 http://www.ncbi.nlm.nih.gov/gene/10725 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007150 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA NFE2L2 http://www.ncbi.nlm.nih.gov/gene/4780 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007151 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007152 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA NLGN1 http://www.ncbi.nlm.nih.gov/gene/22871 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007153 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA NUPL1 http://www.ncbi.nlm.nih.gov/gene/9818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007154 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA PAPD5 http://www.ncbi.nlm.nih.gov/gene/64282 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007155 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA PHF17 http://www.ncbi.nlm.nih.gov/gene/79960 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007156 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA PIP5K2B http://www.ncbi.nlm.nih.gov/gene/ 8396 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007157 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA PKIA http://www.ncbi.nlm.nih.gov/gene/5569 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007158 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA POLH http://www.ncbi.nlm.nih.gov/gene/5429 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007159 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA PPP1R12A http://www.ncbi.nlm.nih.gov/gene/4659 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007160 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA PPP1R15B http://www.ncbi.nlm.nih.gov/gene/84919 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007161 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA PPP6C http://www.ncbi.nlm.nih.gov/gene/5537 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007162 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA PTEN http://www.ncbi.nlm.nih.gov/gene/11191 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007163 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA PTP4A1 http://www.ncbi.nlm.nih.gov/gene/7803 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007164 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA PXMP3 http://www.ncbi.nlm.nih.gov/gene/5828 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007165 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA RAB8B http://www.ncbi.nlm.nih.gov/gene/51762 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007166 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA RABGAP1 http://www.ncbi.nlm.nih.gov/gene/23637 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007167 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA RACGAP1P http://www.ncbi.nlm.nih.gov/gene/29127 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007168 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA RAD23B http://www.ncbi.nlm.nih.gov/gene/5887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007169 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA RBL2 http://www.ncbi.nlm.nih.gov/gene/5934 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007170 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA RIOK3 http://www.ncbi.nlm.nih.gov/gene/8780 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007171 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA RNF149 http://www.ncbi.nlm.nih.gov/gene/284996 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007172 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA RORA http://www.ncbi.nlm.nih.gov/gene/6095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007173 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA RPS6KA5 http://www.ncbi.nlm.nih.gov/gene/9252 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007174 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA RRM2B http://www.ncbi.nlm.nih.gov/gene/50484 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007175 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA RUNX1 http://www.ncbi.nlm.nih.gov/gene/861 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007176 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA SERP1 http://www.ncbi.nlm.nih.gov/gene/27230 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007177 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA SLC1A5 http://www.ncbi.nlm.nih.gov/gene/6510 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007178 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA SLC36A1 http://www.ncbi.nlm.nih.gov/gene/206358 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007179 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA SLMO2 http://www.ncbi.nlm.nih.gov/gene/51012 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007180 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA SOCS4 http://www.ncbi.nlm.nih.gov/gene/122809 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007181 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA SPRED2 http://www.ncbi.nlm.nih.gov/gene/200734 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007182 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA STRBP http://www.ncbi.nlm.nih.gov/gene/55342 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007183 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA STRN3 http://www.ncbi.nlm.nih.gov/gene/29966 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007184 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA THAP5 http://www.ncbi.nlm.nih.gov/gene/168451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007185 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA TIMM17A http://www.ncbi.nlm.nih.gov/gene/10440 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007186 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA TMEM68 http://www.ncbi.nlm.nih.gov/gene/137695 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007187 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA TNRC6A http://www.ncbi.nlm.nih.gov/gene/27327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007188 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA TPD52 http://www.ncbi.nlm.nih.gov/gene/7163 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007189 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA TRA2A http://www.ncbi.nlm.nih.gov/gene/29896 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007190 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA TRUB1 http://www.ncbi.nlm.nih.gov/gene/142940 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007191 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA UBE2K http://www.ncbi.nlm.nih.gov/gene/3093 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007192 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA VEZT http://www.ncbi.nlm.nih.gov/gene/55591 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007193 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA WASL http://www.ncbi.nlm.nih.gov/gene/8976 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007194 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA YME1L1 http://www.ncbi.nlm.nih.gov/gene/10730 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007195 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA YPEL5 http://www.ncbi.nlm.nih.gov/gene/51646 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007196 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA YWHAG http://www.ncbi.nlm.nih.gov/gene/7532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007197 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA ZBTB38 http://www.ncbi.nlm.nih.gov/gene/253461 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007198 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA ZNF160 http://www.ncbi.nlm.nih.gov/gene/90338 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007199 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA ZNF238 http://www.ncbi.nlm.nih.gov/gene/10472 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007200 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA ZNF264 http://www.ncbi.nlm.nih.gov/gene/9422 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007201 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA ZNF281 http://www.ncbi.nlm.nih.gov/gene/23528 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007202 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA ZNF292 http://www.ncbi.nlm.nih.gov/gene/23036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007203 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA ZNF365 http://www.ncbi.nlm.nih.gov/gene/22891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007204 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA ZNF652 http://www.ncbi.nlm.nih.gov/gene/22834 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007205 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA ZNF780B http://www.ncbi.nlm.nih.gov/gene/163131 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007206 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-1 - Host mRNA ZNF805 http://www.ncbi.nlm.nih.gov/gene/390980 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007207 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA ABCE1 http://www.ncbi.nlm.nih.gov/gene/647150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007208 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA ABLIM1 http://www.ncbi.nlm.nih.gov/gene/3983 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007209 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA ABT1 http://www.ncbi.nlm.nih.gov/gene/29777 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007210 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA ADCY7 http://www.ncbi.nlm.nih.gov/gene/113 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007211 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA AIMP1 http://www.ncbi.nlm.nih.gov/gene/9255 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007212 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA AP3M2 http://www.ncbi.nlm.nih.gov/gene/10947 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007213 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA ARFGEF1 http://www.ncbi.nlm.nih.gov/gene/10565 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007214 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA BACH1 http://www.ncbi.nlm.nih.gov/gene/571 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007215 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA BRWD1 http://www.ncbi.nlm.nih.gov/gene/54014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007216 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA BTBD1 http://www.ncbi.nlm.nih.gov/gene/53339 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007217 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA CALM2 http://www.ncbi.nlm.nih.gov/gene/808 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007218 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA CCDC93 http://www.ncbi.nlm.nih.gov/gene/54520 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007219 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007220 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA CDC23 http://www.ncbi.nlm.nih.gov/gene/8697 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007221 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA CDC42SE2 http://www.ncbi.nlm.nih.gov/gene/56990 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007222 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA CERK http://www.ncbi.nlm.nih.gov/gene/64781 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007223 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA CLCN5 http://www.ncbi.nlm.nih.gov/gene/1184 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007224 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA COG5 http://www.ncbi.nlm.nih.gov/gene/10466 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007225 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA COX11 http://www.ncbi.nlm.nih.gov/gene/1353 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007226 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA CPEB2 http://www.ncbi.nlm.nih.gov/gene/132864 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007227 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA CREBZF http://www.ncbi.nlm.nih.gov/gene/58487 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007228 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA CTDSP2 http://www.ncbi.nlm.nih.gov/gene/10106 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007229 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA DENND5B http://www.ncbi.nlm.nih.gov/gene/160518 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007230 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA DNAJB14 http://www.ncbi.nlm.nih.gov/gene/79982 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007231 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA DPY19L1 http://www.ncbi.nlm.nih.gov/gene/23333 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007232 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA E2F3 http://www.ncbi.nlm.nih.gov/gene/1871 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007233 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA EIF2B1 http://www.ncbi.nlm.nih.gov/gene/1967 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007234 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA EIF4G3 http://www.ncbi.nlm.nih.gov/gene/8672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007235 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA FAM76B http://www.ncbi.nlm.nih.gov/gene/143684 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007236 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA FNDC3B http://www.ncbi.nlm.nih.gov/gene/64778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007237 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA FRS2 http://www.ncbi.nlm.nih.gov/gene/10818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007238 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA FZD6 http://www.ncbi.nlm.nih.gov/gene/8323 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007239 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA G2E3 http://www.ncbi.nlm.nih.gov/gene/55632 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007240 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA GLS http://www.ncbi.nlm.nih.gov/gene/2744 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007241 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA GNPTAB http://www.ncbi.nlm.nih.gov/gene/79158 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007242 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA HIAT1 http://www.ncbi.nlm.nih.gov/gene/64645 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007243 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA IGF1R http://www.ncbi.nlm.nih.gov/gene/3480 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007244 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA IGSF11 http://www.ncbi.nlm.nih.gov/gene/152404 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007245 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA IQGAP1 http://www.ncbi.nlm.nih.gov/gene/8826 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007246 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA IRF2BP2 http://www.ncbi.nlm.nih.gov/gene/359948 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007247 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA KPNA4 http://www.ncbi.nlm.nih.gov/gene/3840 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007248 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA KRAS http://www.ncbi.nlm.nih.gov/gene/3845 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007249 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA L2HGDH http://www.ncbi.nlm.nih.gov/gene/79944 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007250 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA LIMA1 http://www.ncbi.nlm.nih.gov/gene/51474 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007251 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA LONP2 http://www.ncbi.nlm.nih.gov/gene/83752 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007252 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA LRCH3 http://www.ncbi.nlm.nih.gov/gene/84859 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007253 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA LRRC59 http://www.ncbi.nlm.nih.gov/gene/55379 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007254 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA MED17 http://www.ncbi.nlm.nih.gov/gene/9440 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007255 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA MKRN3 http://www.ncbi.nlm.nih.gov/gene/7681 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007256 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA MPP5 http://www.ncbi.nlm.nih.gov/gene/64398 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007257 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA MRPS35 http://www.ncbi.nlm.nih.gov/gene/60488 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007258 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA NFAT5 http://www.ncbi.nlm.nih.gov/gene/10725 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007259 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA NFE2L2 http://www.ncbi.nlm.nih.gov/gene/4780 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007260 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA OGFOD2 http://www.ncbi.nlm.nih.gov/gene/79676 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007261 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA PAPD5 http://www.ncbi.nlm.nih.gov/gene/64282 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007262 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA PAPOLG http://www.ncbi.nlm.nih.gov/gene/64895 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007263 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA PHACTR4 http://www.ncbi.nlm.nih.gov/gene/65979 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007264 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA PHF17 http://www.ncbi.nlm.nih.gov/gene/79960 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007265 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA POLH http://www.ncbi.nlm.nih.gov/gene/5429 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007266 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA PTEN http://www.ncbi.nlm.nih.gov/gene/11191 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007267 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA RACGAP1P http://www.ncbi.nlm.nih.gov/gene/29127 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007268 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA RBL2 http://www.ncbi.nlm.nih.gov/gene/5934 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007269 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA RNF187 http://www.ncbi.nlm.nih.gov/gene/149603 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007270 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA RPS6KA5 http://www.ncbi.nlm.nih.gov/gene/9252 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007271 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA RUNX1 http://www.ncbi.nlm.nih.gov/gene/861 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007272 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA SLAIN2 http://www.ncbi.nlm.nih.gov/gene/57606 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007273 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA SLC1A5 http://www.ncbi.nlm.nih.gov/gene/6510 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007274 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA SLMO2 http://www.ncbi.nlm.nih.gov/gene/51012 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007275 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA STAMBP http://www.ncbi.nlm.nih.gov/gene/10617 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007276 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA STRN3 http://www.ncbi.nlm.nih.gov/gene/29966 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007277 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA TIMM17A http://www.ncbi.nlm.nih.gov/gene/10440 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007278 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA TMEM123 http://www.ncbi.nlm.nih.gov/gene/114908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007279 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA TMEM194B http://www.ncbi.nlm.nih.gov/gene/100131211 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007280 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA TNRC6A http://www.ncbi.nlm.nih.gov/gene/27327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007281 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA TPD52 http://www.ncbi.nlm.nih.gov/gene/7163 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007282 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA TRIM4 http://www.ncbi.nlm.nih.gov/gene/89122 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007283 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA VEZT http://www.ncbi.nlm.nih.gov/gene/55591 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007284 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA WASL http://www.ncbi.nlm.nih.gov/gene/8976 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007285 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA YWHAG http://www.ncbi.nlm.nih.gov/gene/7532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007286 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA ZBTB38 http://www.ncbi.nlm.nih.gov/gene/253461 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007287 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA ZNF160 http://www.ncbi.nlm.nih.gov/gene/90338 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007288 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA ZNF264 http://www.ncbi.nlm.nih.gov/gene/9422 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007289 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA ZNF281 http://www.ncbi.nlm.nih.gov/gene/23528 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007290 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA ZNF318 http://www.ncbi.nlm.nih.gov/gene/24149 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007291 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA ZNF507 http://www.ncbi.nlm.nih.gov/gene/22847 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007292 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA ZNF518B http://www.ncbi.nlm.nih.gov/gene/85460 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007293 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 BC-3 - Host mRNA ZNF780B http://www.ncbi.nlm.nih.gov/gene/163131 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007294 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-5(miR-K12-5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 - - Host Protein RTA http://www.ncbi.nlm.nih.gov/gene/116535 Downregulation ChIP and KSHV genome array, Quantitative RT-PCR, MeDIP, Luciferase assay. 20071580 However, BAC36 miR consistently expressed elevated levels of viral lytic genes, including the immediate-early transcriptional activator Rta (ORF50). At least one KSHV microRNA (miR-K12-5) was capable of suppressing ORF50 mRNA, but poor seed sequence alignments suggest that these targets may be indirect. We conclude that KSHV miRNA targets multiple pathways to maintain the latent state of the KSHV genome, including repression of the viral immediate-early protein Rta and a cellular factor, Rbl2, that regulates global epigenetic reprogramming. VHID00007295 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 - - Host mRNA THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 Downregulation - 19158788 THBS1 mRNA was downregulated in cells engineered to express KSHV miRNAs and also showed that THBS1 translation is inhibited by several KSHV miRNAs, in particular by miR-K12-6-3p, which shows miRNA seed complementarity to two sites in the THBS1 mRNA 3'UTR. . VHID00007296 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BCBL1 - Host mRNA Bach1 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00007297 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BCBL1 - Host mRNA THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00007298 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K12-6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 - - Host Protein THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00007299 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K12-6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 293 Cells - Host Protein THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 Downregulation Luciferase de-repression assay. 17500590 We performed luciferase de-repression assays by co-transfection of the THBS1 3'UTR reporter and 2'OMe RNAs specific to individual KSHV miRNAs. Our results demonstrate that THBS1 is targeted by multiple KSHV miRNAs; in particular, miR-K12-1, miR-K12-3-3p, miR-K12-6-3p, and miR-K12-11 lead to strong de-repression of the reporter. VHID00007300 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K12-6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 Lymphocytes - Host Protein THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 KSHV miR-K12-1, miR-K12-3-3p, miR-K12-6-3p, and miR-K12-11 reduce the expression of THBS1(thrombospondin 1) by interaction with the THBS1 4' UTR. VHID00007301 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 - - Host Protein THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00007302 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA MARCH8 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007303 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ABI1 http://www.ncbi.nlm.nih.gov/gene/10006 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007304 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ACYP2 http://www.ncbi.nlm.nih.gov/gene/98 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007305 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ADCY1 http://www.ncbi.nlm.nih.gov/gene/107 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007306 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ALG10B http://www.ncbi.nlm.nih.gov/gene/144245 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007307 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA AMN1 http://www.ncbi.nlm.nih.gov/gene/196394 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007308 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA AP1G1 http://www.ncbi.nlm.nih.gov/gene/164 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007309 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ARFGAP3 http://www.ncbi.nlm.nih.gov/gene/26286 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007310 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ARPC4 http://www.ncbi.nlm.nih.gov/gene/26140 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007311 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ASCC3 http://www.ncbi.nlm.nih.gov/gene/10973 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007312 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA BACH1 http://www.ncbi.nlm.nih.gov/gene/571 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007313 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA BAZ2A http://www.ncbi.nlm.nih.gov/gene/11176 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007314 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA BCL7A http://www.ncbi.nlm.nih.gov/gene/605 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007315 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA BRWD1 http://www.ncbi.nlm.nih.gov/gene/54014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007316 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA BTG2 http://www.ncbi.nlm.nih.gov/gene/7832 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007317 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA BTG3 http://www.ncbi.nlm.nih.gov/gene/10950 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007318 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA C11orf30 http://www.ncbi.nlm.nih.gov/gene/56946 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007319 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA C6orf130 http://www.ncbi.nlm.nih.gov/gene/221443 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007320 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA C9orf80 http://www.ncbi.nlm.nih.gov/gene/58493 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007321 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA CALM1 http://www.ncbi.nlm.nih.gov/gene/808 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007322 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA CALU http://www.ncbi.nlm.nih.gov/gene/813 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007323 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA CBLL1 http://www.ncbi.nlm.nih.gov/gene/79872 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007324 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA CCDC88A http://www.ncbi.nlm.nih.gov/gene/55704 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007325 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA CCNJ http://www.ncbi.nlm.nih.gov/gene/54619 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007326 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA CDC42SE1 http://www.ncbi.nlm.nih.gov/gene/56882 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007327 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA CDC73 http://www.ncbi.nlm.nih.gov/gene/79577 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007328 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA CGRRF1 http://www.ncbi.nlm.nih.gov/gene/10668 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007329 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA CLEC2D http://www.ncbi.nlm.nih.gov/gene/29121 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007330 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA COPG http://www.ncbi.nlm.nih.gov/gene/22820 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007331 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA CXorf15 http://www.ncbi.nlm.nih.gov/gene/55787 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007332 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA DCK http://www.ncbi.nlm.nih.gov/gene/1633 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007333 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA DDX17 http://www.ncbi.nlm.nih.gov/gene/10521 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007334 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA DDX47 http://www.ncbi.nlm.nih.gov/gene/51202 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007335 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA DNAL1 http://www.ncbi.nlm.nih.gov/gene/83544 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007336 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA DZIP3 http://www.ncbi.nlm.nih.gov/gene/9666 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007337 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA E2F7 http://www.ncbi.nlm.nih.gov/gene/144455 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007338 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA EFHD2 http://www.ncbi.nlm.nih.gov/gene/79180 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007339 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA EIF1AD http://www.ncbi.nlm.nih.gov/gene/84285 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007340 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA FAM107B http://www.ncbi.nlm.nih.gov/gene/83641 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007341 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA FAM171B http://www.ncbi.nlm.nih.gov/gene/165215 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007342 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA FAM91A1 http://www.ncbi.nlm.nih.gov/gene/157769 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007343 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA FAM98B http://www.ncbi.nlm.nih.gov/gene/283742 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007344 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA FNIP1 http://www.ncbi.nlm.nih.gov/gene/96459 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007345 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA FRS2 http://www.ncbi.nlm.nih.gov/gene/10818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007346 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA GAPDH http://www.ncbi.nlm.nih.gov/gene/729403 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007347 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA GGPS1 http://www.ncbi.nlm.nih.gov/gene/9453 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007348 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA GPN3 http://www.ncbi.nlm.nih.gov/gene/51184 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007349 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA GSTCD http://www.ncbi.nlm.nih.gov/gene/79807 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007350 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA GTPBP10 http://www.ncbi.nlm.nih.gov/gene/85865 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007351 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA HMG20A http://www.ncbi.nlm.nih.gov/gene/10363 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007352 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA IKZF4 http://www.ncbi.nlm.nih.gov/gene/64375 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007353 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA IMPA1 http://www.ncbi.nlm.nih.gov/gene/3612 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007354 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA INO80D http://www.ncbi.nlm.nih.gov/gene/54891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007355 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA INTS6 http://www.ncbi.nlm.nih.gov/gene/26512 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007356 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA JAK1 http://www.ncbi.nlm.nih.gov/gene/3716 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007357 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA JMJD1C http://www.ncbi.nlm.nih.gov/gene/221037 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007358 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA KDM5C http://www.ncbi.nlm.nih.gov/gene/8242 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007359 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA KIAA0240 http://www.ncbi.nlm.nih.gov/gene/23506 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007360 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA KIAA0317 http://www.ncbi.nlm.nih.gov/gene/9870 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007361 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA KLHL11 http://www.ncbi.nlm.nih.gov/gene/55175 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007362 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA KLHL14 http://www.ncbi.nlm.nih.gov/gene/57565 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007363 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA LANCL1 http://www.ncbi.nlm.nih.gov/gene/10314 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007364 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA LDLRAP1 http://www.ncbi.nlm.nih.gov/gene/26119 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007365 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA LMBR1 http://www.ncbi.nlm.nih.gov/gene/64327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007366 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA LRRC57 http://www.ncbi.nlm.nih.gov/gene/255252 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007367 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA LYSMD3 http://www.ncbi.nlm.nih.gov/gene/116068 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007368 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA M6PR http://www.ncbi.nlm.nih.gov/gene/4074 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007369 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA MAP4K4 http://www.ncbi.nlm.nih.gov/gene/9448 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007370 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA MCM5 http://www.ncbi.nlm.nih.gov/gene/4174 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007371 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA MDM2 http://www.ncbi.nlm.nih.gov/gene/4193 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007372 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA MDM4 http://www.ncbi.nlm.nih.gov/gene/4194 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007373 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA MED21 http://www.ncbi.nlm.nih.gov/gene/9412 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007374 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA MEF2A http://www.ncbi.nlm.nih.gov/gene/4205 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007375 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA MKLN1 http://www.ncbi.nlm.nih.gov/gene/4289 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007376 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA MLEC http://www.ncbi.nlm.nih.gov/gene/9761 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007377 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA MMGT1 http://www.ncbi.nlm.nih.gov/gene/93380 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007378 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA MTMR12 http://www.ncbi.nlm.nih.gov/gene/54545 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007379 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA MTMR9 http://www.ncbi.nlm.nih.gov/gene/66036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007380 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA MTX3 http://www.ncbi.nlm.nih.gov/gene/345778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007381 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA MXD1 http://www.ncbi.nlm.nih.gov/gene/4084 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007382 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA MXI1 http://www.ncbi.nlm.nih.gov/gene/4601 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007383 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA NHEDC2 http://www.ncbi.nlm.nih.gov/gene/133308 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007384 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA NUDT1 http://www.ncbi.nlm.nih.gov/gene/4521 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007385 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA NUDT19 http://www.ncbi.nlm.nih.gov/gene/390916 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007386 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA NUDT21 http://www.ncbi.nlm.nih.gov/gene/11051 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007387 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA NUPL1 http://www.ncbi.nlm.nih.gov/gene/9818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007388 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA OBFC2A http://www.ncbi.nlm.nih.gov/gene/64859 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007389 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA PER2 http://www.ncbi.nlm.nih.gov/gene/8864 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007390 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA PHC3 http://www.ncbi.nlm.nih.gov/gene/80012 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007391 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA PHF6 http://www.ncbi.nlm.nih.gov/gene/84295 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007392 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA PITPNB http://www.ncbi.nlm.nih.gov/gene/23760 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007393 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA PM20D2 http://www.ncbi.nlm.nih.gov/gene/135293 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007394 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA POLE3 http://www.ncbi.nlm.nih.gov/gene/54107 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007395 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA POLR1B http://www.ncbi.nlm.nih.gov/gene/84172 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007396 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA POU2F1 http://www.ncbi.nlm.nih.gov/gene/5451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007397 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA PPP1R2 http://www.ncbi.nlm.nih.gov/gene/5504 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007398 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA PRDM15 http://www.ncbi.nlm.nih.gov/gene/63977 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007399 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA PRDM4 http://www.ncbi.nlm.nih.gov/gene/11108 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007400 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA PTCD3 http://www.ncbi.nlm.nih.gov/gene/55037 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007401 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA PTPRC http://www.ncbi.nlm.nih.gov/gene/5788 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007402 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA RAB22A http://www.ncbi.nlm.nih.gov/gene/57403 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007403 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA RABL3 http://www.ncbi.nlm.nih.gov/gene/285282 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007404 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA RAD23B http://www.ncbi.nlm.nih.gov/gene/5887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007405 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA RBM27 http://www.ncbi.nlm.nih.gov/gene/54439 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007406 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA RBMXL1 http://www.ncbi.nlm.nih.gov/gene/494115 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007407 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA RFWD2 http://www.ncbi.nlm.nih.gov/gene/64326 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007408 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA RFX7 http://www.ncbi.nlm.nih.gov/gene/64864 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007409 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA RGL1 http://www.ncbi.nlm.nih.gov/gene/23179 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007410 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA RNF125 http://www.ncbi.nlm.nih.gov/gene/54941 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007411 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA RPL23 http://www.ncbi.nlm.nih.gov/gene/9349 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007412 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA RSBN1 http://www.ncbi.nlm.nih.gov/gene/54665 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007413 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA RUFY2 http://www.ncbi.nlm.nih.gov/gene/55680 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007414 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA SAMD8 http://www.ncbi.nlm.nih.gov/gene/142891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007415 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA SEL1L http://www.ncbi.nlm.nih.gov/gene/6400 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007416 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA SENP1 http://www.ncbi.nlm.nih.gov/gene/29843 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007417 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA SFRS7 http://www.ncbi.nlm.nih.gov/gene/6432 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007418 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA SGTB http://www.ncbi.nlm.nih.gov/gene/54557 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007419 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA SH3GL2 http://www.ncbi.nlm.nih.gov/gene/6456 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007420 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA SIKE1 http://www.ncbi.nlm.nih.gov/gene/80143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007421 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA SIRT2 http://www.ncbi.nlm.nih.gov/gene/22933 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007422 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA SLC23A2 http://www.ncbi.nlm.nih.gov/gene/9962 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007423 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA SMURF2 http://www.ncbi.nlm.nih.gov/gene/64750 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007424 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA SNX16 http://www.ncbi.nlm.nih.gov/gene/64089 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007425 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA SNX2 http://www.ncbi.nlm.nih.gov/gene/6643 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007426 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA SOCS4 http://www.ncbi.nlm.nih.gov/gene/122809 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007427 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA SPTLC2 http://www.ncbi.nlm.nih.gov/gene/9517 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007428 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA SQSTM1 http://www.ncbi.nlm.nih.gov/gene/8878 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007429 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA SRP54 http://www.ncbi.nlm.nih.gov/gene/650638 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007430 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA SSX2IP http://www.ncbi.nlm.nih.gov/gene/117178 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007431 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA STAG2 http://www.ncbi.nlm.nih.gov/gene/10735 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007432 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA STRN http://www.ncbi.nlm.nih.gov/gene/6801 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007433 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA SWAP70 http://www.ncbi.nlm.nih.gov/gene/23075 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007434 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA SYNCRIP http://www.ncbi.nlm.nih.gov/gene/10492 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007435 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA TATDN3 http://www.ncbi.nlm.nih.gov/gene/128387 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007436 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA TCF20 http://www.ncbi.nlm.nih.gov/gene/6942 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007437 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA TERF1 http://www.ncbi.nlm.nih.gov/gene/646316 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007438 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA TET3 http://www.ncbi.nlm.nih.gov/gene/200424 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007439 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA TFDP1 http://www.ncbi.nlm.nih.gov/gene/7027 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007440 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA TNRC6B http://www.ncbi.nlm.nih.gov/gene/23112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007441 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA TOP2A http://www.ncbi.nlm.nih.gov/gene/7153 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007442 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA TRIM14 http://www.ncbi.nlm.nih.gov/gene/9830 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007443 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA TSPYL5 http://www.ncbi.nlm.nih.gov/gene/85453 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007444 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA UBE2F http://www.ncbi.nlm.nih.gov/gene/140739 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007445 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA UBE2V1 http://www.ncbi.nlm.nih.gov/gene/387522 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007446 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA UBP1 http://www.ncbi.nlm.nih.gov/gene/7342 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007447 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA UBXN7 http://www.ncbi.nlm.nih.gov/gene/26043 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007448 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA UHMK1 http://www.ncbi.nlm.nih.gov/gene/127933 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007449 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA USP22 http://www.ncbi.nlm.nih.gov/gene/23326 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007450 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA VEZF1 http://www.ncbi.nlm.nih.gov/gene/7716 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007451 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA VPS37C http://www.ncbi.nlm.nih.gov/gene/55048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007452 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA WDR26 http://www.ncbi.nlm.nih.gov/gene/80232 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007453 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA WDR33 http://www.ncbi.nlm.nih.gov/gene/55339 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007454 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA WDR42A http://www.ncbi.nlm.nih.gov/gene/50717 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007455 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA WDR55 http://www.ncbi.nlm.nih.gov/gene/54853 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007456 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA WDR82 http://www.ncbi.nlm.nih.gov/gene/80335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007457 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA XPNPEP3 http://www.ncbi.nlm.nih.gov/gene/63929 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007458 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA YOD1 http://www.ncbi.nlm.nih.gov/gene/55432 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007459 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ZBTB38 http://www.ncbi.nlm.nih.gov/gene/253461 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007460 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ZC3H4 http://www.ncbi.nlm.nih.gov/gene/23211 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007461 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ZKSCAN5 http://www.ncbi.nlm.nih.gov/gene/23660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007462 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ZMAT3 http://www.ncbi.nlm.nih.gov/gene/64393 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007463 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ZMIZ1 http://www.ncbi.nlm.nih.gov/gene/57178 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007464 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ZNF134 http://www.ncbi.nlm.nih.gov/gene/7693 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007465 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ZNF22 http://www.ncbi.nlm.nih.gov/gene/7570 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007466 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ZNF346 http://www.ncbi.nlm.nih.gov/gene/23567 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007467 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ZNF445 http://www.ncbi.nlm.nih.gov/gene/353274 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007468 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ZNF451 http://www.ncbi.nlm.nih.gov/gene/26036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007469 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ZNF485 http://www.ncbi.nlm.nih.gov/gene/220992 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007470 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ZNF525 http://www.ncbi.nlm.nih.gov/gene/170958 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007471 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ZNF609 http://www.ncbi.nlm.nih.gov/gene/23060 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007472 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ZNF701 http://www.ncbi.nlm.nih.gov/gene/55762 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007473 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ZNF776 http://www.ncbi.nlm.nih.gov/gene/284309 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007474 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-1 - Host mRNA ZNF800 http://www.ncbi.nlm.nih.gov/gene/168850 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007475 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ABI1 http://www.ncbi.nlm.nih.gov/gene/10006 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007476 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ACSS2 http://www.ncbi.nlm.nih.gov/gene/55902 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007477 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ALG10B http://www.ncbi.nlm.nih.gov/gene/144245 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007478 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA AMN1 http://www.ncbi.nlm.nih.gov/gene/196394 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007479 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ANAPC13 http://www.ncbi.nlm.nih.gov/gene/25847 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007480 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ANAPC7 http://www.ncbi.nlm.nih.gov/gene/51434 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007481 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ANKIB1 http://www.ncbi.nlm.nih.gov/gene/54467 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007482 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ANKRD57 http://www.ncbi.nlm.nih.gov/gene/65124 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007483 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ANO6 http://www.ncbi.nlm.nih.gov/gene/196527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007484 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA AP1G1 http://www.ncbi.nlm.nih.gov/gene/164 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007485 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA AP1S3 http://www.ncbi.nlm.nih.gov/gene/130340 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007486 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA AP2A1 http://www.ncbi.nlm.nih.gov/gene/160 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007487 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA AP3D1 http://www.ncbi.nlm.nih.gov/gene/8943 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007488 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ARHGAP4 http://www.ncbi.nlm.nih.gov/gene/393 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007489 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ARPC4 http://www.ncbi.nlm.nih.gov/gene/26140 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007490 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ASB7 http://www.ncbi.nlm.nih.gov/gene/140460 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007491 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ASZ1 http://www.ncbi.nlm.nih.gov/gene/136991 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007492 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ATXN1L http://www.ncbi.nlm.nih.gov/gene/342371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007493 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA BACH1 http://www.ncbi.nlm.nih.gov/gene/571 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007494 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA BACH2 http://www.ncbi.nlm.nih.gov/gene/60468 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007495 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA BAZ2A http://www.ncbi.nlm.nih.gov/gene/11176 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007496 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA BCL7A http://www.ncbi.nlm.nih.gov/gene/605 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007497 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA C10orf137 http://www.ncbi.nlm.nih.gov/gene/26098 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007498 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA C11orf30 http://www.ncbi.nlm.nih.gov/gene/56946 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007499 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA C2orf29 http://www.ncbi.nlm.nih.gov/gene/55571 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007500 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA C6orf130 http://www.ncbi.nlm.nih.gov/gene/221443 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007501 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA C9orf80 http://www.ncbi.nlm.nih.gov/gene/58493 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007502 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA CALM1 http://www.ncbi.nlm.nih.gov/gene/808 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007503 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA CALU http://www.ncbi.nlm.nih.gov/gene/813 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007504 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA CASD1 http://www.ncbi.nlm.nih.gov/gene/64921 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007505 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA CASP2 http://www.ncbi.nlm.nih.gov/gene/835 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007506 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA CCDC88A http://www.ncbi.nlm.nih.gov/gene/55704 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007507 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA CCNJ http://www.ncbi.nlm.nih.gov/gene/54619 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007508 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007509 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA CD164 http://www.ncbi.nlm.nih.gov/gene/8763 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007510 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA CDC25A http://www.ncbi.nlm.nih.gov/gene/993 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007511 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA CDC73 http://www.ncbi.nlm.nih.gov/gene/79577 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007512 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA CDCA7L http://www.ncbi.nlm.nih.gov/gene/55536 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007513 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA CENPI http://www.ncbi.nlm.nih.gov/gene/2491 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007514 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA CGRRF1 http://www.ncbi.nlm.nih.gov/gene/10668 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007515 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA CLCN3 http://www.ncbi.nlm.nih.gov/gene/1182 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007516 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA CLDN11 http://www.ncbi.nlm.nih.gov/gene/5010 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007517 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA CLEC2D http://www.ncbi.nlm.nih.gov/gene/29121 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007518 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA COPG http://www.ncbi.nlm.nih.gov/gene/22820 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007519 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA COX7B2 http://www.ncbi.nlm.nih.gov/gene/170712 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007520 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA CPD http://www.ncbi.nlm.nih.gov/gene/1362 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007521 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA DARS2 http://www.ncbi.nlm.nih.gov/gene/55157 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007522 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA DCK http://www.ncbi.nlm.nih.gov/gene/1633 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007523 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA DDX17 http://www.ncbi.nlm.nih.gov/gene/10521 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007524 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA DDX6 http://www.ncbi.nlm.nih.gov/gene/1656 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007525 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA DICER1 http://www.ncbi.nlm.nih.gov/gene/23405 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007526 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA DIP2B http://www.ncbi.nlm.nih.gov/gene/57609 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007527 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA DVL3 http://www.ncbi.nlm.nih.gov/gene/1857 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007528 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA EFHD2 http://www.ncbi.nlm.nih.gov/gene/79180 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007529 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA EIF1AD http://www.ncbi.nlm.nih.gov/gene/84285 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007530 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA EIF4E3 http://www.ncbi.nlm.nih.gov/gene/317649 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007531 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA EIF4G2 http://www.ncbi.nlm.nih.gov/gene/1982 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007532 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA FAHD2A http://www.ncbi.nlm.nih.gov/gene/51011 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007533 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA FAM107B http://www.ncbi.nlm.nih.gov/gene/83641 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007534 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA FAM171B http://www.ncbi.nlm.nih.gov/gene/165215 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007535 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA FAM178A http://www.ncbi.nlm.nih.gov/gene/55719 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007536 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA FAM91A1 http://www.ncbi.nlm.nih.gov/gene/157769 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007537 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA FNIP1 http://www.ncbi.nlm.nih.gov/gene/96459 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007538 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA GAPVD1 http://www.ncbi.nlm.nih.gov/gene/26130 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007539 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA GCNT4 http://www.ncbi.nlm.nih.gov/gene/51301 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007540 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA GGPS1 http://www.ncbi.nlm.nih.gov/gene/9453 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007541 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA GLE1 http://www.ncbi.nlm.nih.gov/gene/2733 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007542 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA GPN3 http://www.ncbi.nlm.nih.gov/gene/51184 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007543 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA GRK7 http://www.ncbi.nlm.nih.gov/gene/131890 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007544 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA GRSF1 http://www.ncbi.nlm.nih.gov/gene/2926 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007545 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA GSK3B http://www.ncbi.nlm.nih.gov/gene/2932 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007546 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA GSTCD http://www.ncbi.nlm.nih.gov/gene/79807 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007547 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA GTPBP10 http://www.ncbi.nlm.nih.gov/gene/85865 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007548 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA HDAC7 http://www.ncbi.nlm.nih.gov/gene/51564 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007549 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA HSPA1B http://www.ncbi.nlm.nih.gov/gene/3303 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007550 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA IKZF4 http://www.ncbi.nlm.nih.gov/gene/64375 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007551 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA IMPAD1 http://www.ncbi.nlm.nih.gov/gene/54928 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007552 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA INTS6 http://www.ncbi.nlm.nih.gov/gene/26512 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007553 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA IPPK http://www.ncbi.nlm.nih.gov/gene/64768 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007554 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ITGAL http://www.ncbi.nlm.nih.gov/gene/3683 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007555 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA JMJD1C http://www.ncbi.nlm.nih.gov/gene/221037 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007556 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA KBTBD2 http://www.ncbi.nlm.nih.gov/gene/25948 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007557 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA KDELC2 http://www.ncbi.nlm.nih.gov/gene/143888 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007558 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA KDM5C http://www.ncbi.nlm.nih.gov/gene/8242 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007559 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA KIAA0240 http://www.ncbi.nlm.nih.gov/gene/23506 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007560 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA KIAA0317 http://www.ncbi.nlm.nih.gov/gene/9870 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007561 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA KLHL11 http://www.ncbi.nlm.nih.gov/gene/55175 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007562 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA KLHL15 http://www.ncbi.nlm.nih.gov/gene/80311 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007563 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA KPNA1 http://www.ncbi.nlm.nih.gov/gene/3836 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007564 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA KSR1 http://www.ncbi.nlm.nih.gov/gene/8844 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007565 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA LANCL1 http://www.ncbi.nlm.nih.gov/gene/10314 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007566 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA LARGE http://www.ncbi.nlm.nih.gov/gene/9215 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007567 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA LARS http://www.ncbi.nlm.nih.gov/gene/51520 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007568 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA LASP1 http://www.ncbi.nlm.nih.gov/gene/3927 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007569 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA LATS2 http://www.ncbi.nlm.nih.gov/gene/26524 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007570 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA LIN7C http://www.ncbi.nlm.nih.gov/gene/55327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007571 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA LPP http://www.ncbi.nlm.nih.gov/gene/4026 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007572 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA LRRC57 http://www.ncbi.nlm.nih.gov/gene/255252 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007573 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA M6PR http://www.ncbi.nlm.nih.gov/gene/4074 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007574 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA MAP4 http://www.ncbi.nlm.nih.gov/gene/4134 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007575 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA MAPK8 http://www.ncbi.nlm.nih.gov/gene/5599 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007576 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA MCM5 http://www.ncbi.nlm.nih.gov/gene/4174 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007577 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA MDM4 http://www.ncbi.nlm.nih.gov/gene/4194 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007578 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA MED21 http://www.ncbi.nlm.nih.gov/gene/9412 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007579 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA MFN2 http://www.ncbi.nlm.nih.gov/gene/9927 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007580 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA MINK1 http://www.ncbi.nlm.nih.gov/gene/50488 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007581 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA MLEC http://www.ncbi.nlm.nih.gov/gene/9761 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007582 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA MOBKL2A http://www.ncbi.nlm.nih.gov/gene/126308 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007583 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA MTMR12 http://www.ncbi.nlm.nih.gov/gene/54545 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007584 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA MTMR4 http://www.ncbi.nlm.nih.gov/gene/9110 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007585 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA MXD1 http://www.ncbi.nlm.nih.gov/gene/4084 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007586 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA MXI1 http://www.ncbi.nlm.nih.gov/gene/4601 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007587 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA NAT15 http://www.ncbi.nlm.nih.gov/gene/79903 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007588 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA NR2C2 http://www.ncbi.nlm.nih.gov/gene/7182 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007589 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA NUDT19 http://www.ncbi.nlm.nih.gov/gene/390916 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007590 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA NUDT21 http://www.ncbi.nlm.nih.gov/gene/11051 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007591 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA NUPL1 http://www.ncbi.nlm.nih.gov/gene/9818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007592 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA OBFC2A http://www.ncbi.nlm.nih.gov/gene/64859 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007593 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA PCF11 http://www.ncbi.nlm.nih.gov/gene/51585 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007594 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA PCMT1 http://www.ncbi.nlm.nih.gov/gene/5110 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007595 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA PDE12 http://www.ncbi.nlm.nih.gov/gene/201626 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007596 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA PDLIM5 http://www.ncbi.nlm.nih.gov/gene/10611 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007597 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA PHF6 http://www.ncbi.nlm.nih.gov/gene/84295 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007598 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA PHLPP2 http://www.ncbi.nlm.nih.gov/gene/23035 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007599 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA PITPNB http://www.ncbi.nlm.nih.gov/gene/23760 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007600 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA PM20D2 http://www.ncbi.nlm.nih.gov/gene/135293 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007601 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA POLE3 http://www.ncbi.nlm.nih.gov/gene/54107 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007602 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA POU2F1 http://www.ncbi.nlm.nih.gov/gene/5451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007603 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA PRDM4 http://www.ncbi.nlm.nih.gov/gene/11108 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007604 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA PRDM5 http://www.ncbi.nlm.nih.gov/gene/11107 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007605 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA PSMB5 http://www.ncbi.nlm.nih.gov/gene/5693 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007606 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA PTCD3 http://www.ncbi.nlm.nih.gov/gene/55037 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007607 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA PTPLAD1 http://www.ncbi.nlm.nih.gov/gene/51495 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007608 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA PTPRC http://www.ncbi.nlm.nih.gov/gene/5788 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007609 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA PURA http://www.ncbi.nlm.nih.gov/gene/5813 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007610 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA RAB12 http://www.ncbi.nlm.nih.gov/gene/201475 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007611 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA RAB22A http://www.ncbi.nlm.nih.gov/gene/57403 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007612 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA RAB23 http://www.ncbi.nlm.nih.gov/gene/51715 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007613 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA RABL3 http://www.ncbi.nlm.nih.gov/gene/285282 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007614 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA RBM16 http://www.ncbi.nlm.nih.gov/gene/22828 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007615 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA RBMXL1 http://www.ncbi.nlm.nih.gov/gene/494115 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007616 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA RC3H2 http://www.ncbi.nlm.nih.gov/gene/54542 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007617 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA REV1 http://www.ncbi.nlm.nih.gov/gene/51455 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007618 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA REV3L http://www.ncbi.nlm.nih.gov/gene/5980 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007619 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA RGL1 http://www.ncbi.nlm.nih.gov/gene/23179 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007620 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA RNF125 http://www.ncbi.nlm.nih.gov/gene/54941 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007621 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA RNF157 http://www.ncbi.nlm.nih.gov/gene/114804 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007622 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA RNF217 http://www.ncbi.nlm.nih.gov/gene/154214 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007623 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA RORA http://www.ncbi.nlm.nih.gov/gene/6095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007624 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA RUFY2 http://www.ncbi.nlm.nih.gov/gene/55680 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007625 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SAMD8 http://www.ncbi.nlm.nih.gov/gene/142891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007626 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SCOC http://www.ncbi.nlm.nih.gov/gene/60592 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007627 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SEC14L1 http://www.ncbi.nlm.nih.gov/gene/6397 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007628 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SEL1L http://www.ncbi.nlm.nih.gov/gene/6400 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007629 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SENP2 http://www.ncbi.nlm.nih.gov/gene/59343 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007630 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SETD1B http://www.ncbi.nlm.nih.gov/gene/23067 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007631 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SGTB http://www.ncbi.nlm.nih.gov/gene/54557 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007632 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SH3BGRL2 http://www.ncbi.nlm.nih.gov/gene/83699 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007633 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SH3GL2 http://www.ncbi.nlm.nih.gov/gene/6456 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007634 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SLC41A2 http://www.ncbi.nlm.nih.gov/gene/84102 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007635 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SLC9A8 http://www.ncbi.nlm.nih.gov/gene/23315 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007636 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SMAD3 http://www.ncbi.nlm.nih.gov/gene/4088 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007637 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SMC1A http://www.ncbi.nlm.nih.gov/gene/8243 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007638 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SMC2 http://www.ncbi.nlm.nih.gov/gene/10592 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007639 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SNX16 http://www.ncbi.nlm.nih.gov/gene/64089 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007640 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SNX2 http://www.ncbi.nlm.nih.gov/gene/6643 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007641 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SOD2 http://www.ncbi.nlm.nih.gov/gene/6648 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007642 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SPTLC2 http://www.ncbi.nlm.nih.gov/gene/9517 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007643 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SQSTM1 http://www.ncbi.nlm.nih.gov/gene/8878 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007644 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SRP54 http://www.ncbi.nlm.nih.gov/gene/650638 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007645 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SSU72 http://www.ncbi.nlm.nih.gov/gene/29101 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007646 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA STXBP3 http://www.ncbi.nlm.nih.gov/gene/6814 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007647 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SWAP70 http://www.ncbi.nlm.nih.gov/gene/23075 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007648 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA SYNCRIP http://www.ncbi.nlm.nih.gov/gene/10492 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007649 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA TAF6 http://www.ncbi.nlm.nih.gov/gene/6878 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007650 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA TATDN3 http://www.ncbi.nlm.nih.gov/gene/128387 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007651 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA TERF1 http://www.ncbi.nlm.nih.gov/gene/646316 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007652 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA TET3 http://www.ncbi.nlm.nih.gov/gene/200424 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007653 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA TFDP1 http://www.ncbi.nlm.nih.gov/gene/7027 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007654 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA THAP6 http://www.ncbi.nlm.nih.gov/gene/152815 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007655 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA THOC5 http://www.ncbi.nlm.nih.gov/gene/8563 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007656 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA TLN1 http://www.ncbi.nlm.nih.gov/gene/7094 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007657 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA TMEM184B http://www.ncbi.nlm.nih.gov/gene/25829 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007658 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA TMEM20 http://www.ncbi.nlm.nih.gov/gene/159371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007659 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA TNRC6B http://www.ncbi.nlm.nih.gov/gene/23112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007660 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA TOP2A http://www.ncbi.nlm.nih.gov/gene/7153 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007661 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA TPD52L1 http://www.ncbi.nlm.nih.gov/gene/7164 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007662 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA TPX2 http://www.ncbi.nlm.nih.gov/gene/22974 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007663 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA TRIM14 http://www.ncbi.nlm.nih.gov/gene/9830 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007664 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA TRIM23 http://www.ncbi.nlm.nih.gov/gene/373 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007665 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA TSPYL5 http://www.ncbi.nlm.nih.gov/gene/85453 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007666 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA UBE2F http://www.ncbi.nlm.nih.gov/gene/140739 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007667 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA UBE2G2 http://www.ncbi.nlm.nih.gov/gene/7327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007668 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA UBE2V1 http://www.ncbi.nlm.nih.gov/gene/387522 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007669 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA UBE4A http://www.ncbi.nlm.nih.gov/gene/9354 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007670 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA UCP2 http://www.ncbi.nlm.nih.gov/gene/7351 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007671 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA USP22 http://www.ncbi.nlm.nih.gov/gene/23326 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007672 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA VEZF1 http://www.ncbi.nlm.nih.gov/gene/7716 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007673 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA VPS25 http://www.ncbi.nlm.nih.gov/gene/84313 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007674 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA VPS37C http://www.ncbi.nlm.nih.gov/gene/55048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007675 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA VTA1 http://www.ncbi.nlm.nih.gov/gene/51534 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007676 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA WDR42A http://www.ncbi.nlm.nih.gov/gene/50717 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007677 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA WDR82 http://www.ncbi.nlm.nih.gov/gene/80335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007678 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA WIBG http://www.ncbi.nlm.nih.gov/gene/84305 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007679 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA WWP2 http://www.ncbi.nlm.nih.gov/gene/11060 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007680 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA XPO1 http://www.ncbi.nlm.nih.gov/gene/7514 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007681 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ZBTB38 http://www.ncbi.nlm.nih.gov/gene/253461 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007682 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ZKSCAN5 http://www.ncbi.nlm.nih.gov/gene/23660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007683 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ZMAT3 http://www.ncbi.nlm.nih.gov/gene/64393 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007684 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ZNF134 http://www.ncbi.nlm.nih.gov/gene/7693 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007685 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ZNF142 http://www.ncbi.nlm.nih.gov/gene/7701 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007686 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ZNF252 http://www.ncbi.nlm.nih.gov/gene/286101 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007687 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ZNF346 http://www.ncbi.nlm.nih.gov/gene/23567 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007688 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ZNF445 http://www.ncbi.nlm.nih.gov/gene/353274 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007689 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ZNF485 http://www.ncbi.nlm.nih.gov/gene/220992 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007690 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ZNF507 http://www.ncbi.nlm.nih.gov/gene/22847 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007691 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ZNF525 http://www.ncbi.nlm.nih.gov/gene/170958 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007692 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ZNF800 http://www.ncbi.nlm.nih.gov/gene/168850 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007693 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ZNF90 http://www.ncbi.nlm.nih.gov/gene/7643 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007694 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 BC-3 - Host mRNA ZWINT http://www.ncbi.nlm.nih.gov/gene/11130 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007695 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K12-6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 - - Host Protein MAF http://www.ncbi.nlm.nih.gov/gene/4094 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00007696 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K12-6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 - - Host Protein MAF http://www.ncbi.nlm.nih.gov/gene/4094 Downregulation qPCR and qRT-PCR, Western blotting, Luciferase reporter assays. 20080955 Site-directed mutagenesis of KSHV miRNA predicted target sites in the MAF 3'UTR abolished silencing, confirming that miR-K12-1, miR-K12-6-5p, and miR-K12-11 regulate MAF by interacting with the 3'UTR. VHID00007697 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K12-6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 - - Host Protein MAF1 http://www.ncbi.nlm.nih.gov/gene/84232 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00007698 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K12-6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 - - Host mRNA MAF http://www.ncbi.nlm.nih.gov/gene/4094 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00007699 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA AHNAK http://www.ncbi.nlm.nih.gov/gene/79026 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007700 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA AKAP13 http://www.ncbi.nlm.nih.gov/gene/11214 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007701 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA ANAPC13 http://www.ncbi.nlm.nih.gov/gene/25847 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007702 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA ANKIB1 http://www.ncbi.nlm.nih.gov/gene/54467 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007703 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA ANKRD12 http://www.ncbi.nlm.nih.gov/gene/23253 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007704 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA AP1S3 http://www.ncbi.nlm.nih.gov/gene/130340 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007705 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA AP3D1 http://www.ncbi.nlm.nih.gov/gene/8943 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007706 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA ARFGAP2 http://www.ncbi.nlm.nih.gov/gene/84364 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007707 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA ATF7 http://www.ncbi.nlm.nih.gov/gene/11016 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007708 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA ATP6V1C1 http://www.ncbi.nlm.nih.gov/gene/528 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007709 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA BAZ2A http://www.ncbi.nlm.nih.gov/gene/11176 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007710 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA BOLA3 http://www.ncbi.nlm.nih.gov/gene/388962 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007711 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA BTG2 http://www.ncbi.nlm.nih.gov/gene/7832 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007712 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA C12orf30 http://www.ncbi.nlm.nih.gov/gene/80018 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007713 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA C13orf23 http://www.ncbi.nlm.nih.gov/gene/80209 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007714 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA C5orf51 http://www.ncbi.nlm.nih.gov/gene/285636 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007715 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA C6orf204 http://www.ncbi.nlm.nih.gov/gene/387119 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007716 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA C7orf58 http://www.ncbi.nlm.nih.gov/gene/79974 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007717 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA CALM1 http://www.ncbi.nlm.nih.gov/gene/808 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007718 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA CALU http://www.ncbi.nlm.nih.gov/gene/813 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007719 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA CAMKK2 http://www.ncbi.nlm.nih.gov/gene/10645 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007720 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA CCDC88C http://www.ncbi.nlm.nih.gov/gene/440193 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007721 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA CD164 http://www.ncbi.nlm.nih.gov/gene/8763 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007722 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA CD48 http://www.ncbi.nlm.nih.gov/gene/962 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007723 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA CDC25A http://www.ncbi.nlm.nih.gov/gene/993 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007724 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA CDK6 http://www.ncbi.nlm.nih.gov/gene/1021 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007725 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA CDKN1A http://www.ncbi.nlm.nih.gov/gene/1026 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007726 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA CLASP2 http://www.ncbi.nlm.nih.gov/gene/23122 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007727 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA CLCN3 http://www.ncbi.nlm.nih.gov/gene/1182 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007728 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA COL4A3BP http://www.ncbi.nlm.nih.gov/gene/10087 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007729 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA COMMD1 http://www.ncbi.nlm.nih.gov/gene/150684 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007730 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA COPS7A http://www.ncbi.nlm.nih.gov/gene/50813 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007731 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA CPD http://www.ncbi.nlm.nih.gov/gene/1362 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007732 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA CPEB4 http://www.ncbi.nlm.nih.gov/gene/80315 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007733 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA DENR http://www.ncbi.nlm.nih.gov/gene/8562 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007734 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA DICER1 http://www.ncbi.nlm.nih.gov/gene/23405 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007735 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA DVL3 http://www.ncbi.nlm.nih.gov/gene/1857 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007736 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA ELL http://www.ncbi.nlm.nih.gov/gene/8178 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007737 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA EXOC5 http://www.ncbi.nlm.nih.gov/gene/10640 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007738 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA EXOSC1 http://www.ncbi.nlm.nih.gov/gene/51013 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007739 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA FAM171B http://www.ncbi.nlm.nih.gov/gene/165215 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007740 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA FAM178A http://www.ncbi.nlm.nih.gov/gene/55719 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007741 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA HSPA1B http://www.ncbi.nlm.nih.gov/gene/3303 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007742 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA IPPK http://www.ncbi.nlm.nih.gov/gene/64768 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007743 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA IRF4 http://www.ncbi.nlm.nih.gov/gene/3662 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007744 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA IRS1 http://www.ncbi.nlm.nih.gov/gene/3667 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007745 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA ITFG3 http://www.ncbi.nlm.nih.gov/gene/83986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007746 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA ITPR1 http://www.ncbi.nlm.nih.gov/gene/3708 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007747 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA KBTBD2 http://www.ncbi.nlm.nih.gov/gene/25948 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007748 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA KIAA0802 http://www.ncbi.nlm.nih.gov/gene/23255 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007749 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA KLHL15 http://www.ncbi.nlm.nih.gov/gene/80311 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007750 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA KLHL18 http://www.ncbi.nlm.nih.gov/gene/23276 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007751 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA LATS2 http://www.ncbi.nlm.nih.gov/gene/26524 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007752 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA LCORL http://www.ncbi.nlm.nih.gov/gene/254251 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007753 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA LIMS1 http://www.ncbi.nlm.nih.gov/gene/3987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007754 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA LIN28B http://www.ncbi.nlm.nih.gov/gene/389421 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007755 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA LIN7C http://www.ncbi.nlm.nih.gov/gene/55327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007756 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA MAP4 http://www.ncbi.nlm.nih.gov/gene/4134 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007757 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA MAPK8 http://www.ncbi.nlm.nih.gov/gene/5599 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007758 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA MAPKAPK2 http://www.ncbi.nlm.nih.gov/gene/9261 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007759 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA MED1 http://www.ncbi.nlm.nih.gov/gene/5469 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007760 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA MFN2 http://www.ncbi.nlm.nih.gov/gene/9927 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007761 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA MINK1 http://www.ncbi.nlm.nih.gov/gene/50488 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007762 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA MOGS http://www.ncbi.nlm.nih.gov/gene/7841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007763 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA MTMR4 http://www.ncbi.nlm.nih.gov/gene/9110 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007764 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA NAT15 http://www.ncbi.nlm.nih.gov/gene/79903 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007765 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA NPTN http://www.ncbi.nlm.nih.gov/gene/27020 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007766 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA NR2C2 http://www.ncbi.nlm.nih.gov/gene/7182 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007767 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA NSD1 http://www.ncbi.nlm.nih.gov/gene/64324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007768 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA NUCKS1 http://www.ncbi.nlm.nih.gov/gene/64710 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007769 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA NUP98 http://www.ncbi.nlm.nih.gov/gene/4928 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007770 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA PANK1 http://www.ncbi.nlm.nih.gov/gene/53354 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007771 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA PCF11 http://www.ncbi.nlm.nih.gov/gene/51585 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007772 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA PDLIM5 http://www.ncbi.nlm.nih.gov/gene/10611 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007773 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA PHLPP2 http://www.ncbi.nlm.nih.gov/gene/23035 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007774 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA PJA2 http://www.ncbi.nlm.nih.gov/gene/9867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007775 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA PLEKHB2 http://www.ncbi.nlm.nih.gov/gene/55041 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007776 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA PRKAB2 http://www.ncbi.nlm.nih.gov/gene/5565 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007777 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA PUM2 http://www.ncbi.nlm.nih.gov/gene/23369 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007778 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA PURA http://www.ncbi.nlm.nih.gov/gene/5813 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007779 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA RAB12 http://www.ncbi.nlm.nih.gov/gene/201475 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007780 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA RAB14 http://www.ncbi.nlm.nih.gov/gene/51552 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007781 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA RNF111 http://www.ncbi.nlm.nih.gov/gene/54778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007782 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA RORA http://www.ncbi.nlm.nih.gov/gene/6095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007783 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA RREB1 http://www.ncbi.nlm.nih.gov/gene/6239 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007784 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA RRP1B http://www.ncbi.nlm.nih.gov/gene/23076 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007785 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA RSF1 http://www.ncbi.nlm.nih.gov/gene/51773 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007786 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA SACM1L http://www.ncbi.nlm.nih.gov/gene/22908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007787 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA SCOC http://www.ncbi.nlm.nih.gov/gene/60592 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007788 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA SEC14L1 http://www.ncbi.nlm.nih.gov/gene/6397 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007789 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA SEC24D http://www.ncbi.nlm.nih.gov/gene/9871 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007790 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA SEC31A http://www.ncbi.nlm.nih.gov/gene/22872 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007791 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA SIAH1 http://www.ncbi.nlm.nih.gov/gene/6477 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007792 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA SMAD3 http://www.ncbi.nlm.nih.gov/gene/4088 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007793 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA SP100 http://www.ncbi.nlm.nih.gov/gene/6672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007794 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA SSU72 http://www.ncbi.nlm.nih.gov/gene/29101 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007795 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA STXBP3 http://www.ncbi.nlm.nih.gov/gene/6814 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007796 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA TACC1 http://www.ncbi.nlm.nih.gov/gene/6867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007797 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA TAOK1 http://www.ncbi.nlm.nih.gov/gene/57551 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007798 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA TAOK3 http://www.ncbi.nlm.nih.gov/gene/51347 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007799 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA TBC1D13 http://www.ncbi.nlm.nih.gov/gene/54662 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007800 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA TET3 http://www.ncbi.nlm.nih.gov/gene/200424 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007801 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA TLN1 http://www.ncbi.nlm.nih.gov/gene/7094 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007802 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA TMEM55B http://www.ncbi.nlm.nih.gov/gene/90809 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007803 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA TNIP1 http://www.ncbi.nlm.nih.gov/gene/10318 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007804 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA TNXA http://www.ncbi.nlm.nih.gov/gene/7148 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007805 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA TTPAL http://www.ncbi.nlm.nih.gov/gene/79183 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007806 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA TXN2 http://www.ncbi.nlm.nih.gov/gene/25828 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007807 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA UBE4A http://www.ncbi.nlm.nih.gov/gene/9354 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007808 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA UCP2 http://www.ncbi.nlm.nih.gov/gene/7351 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007809 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA WDR75 http://www.ncbi.nlm.nih.gov/gene/84128 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007810 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA WIBG http://www.ncbi.nlm.nih.gov/gene/84305 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007811 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA XPO1 http://www.ncbi.nlm.nih.gov/gene/7514 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007812 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA ZBTB33 http://www.ncbi.nlm.nih.gov/gene/10009 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007813 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA ZBTB9 http://www.ncbi.nlm.nih.gov/gene/221504 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007814 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA ZNF192 http://www.ncbi.nlm.nih.gov/gene/7745 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007815 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-5p(miR-K6-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002188 BC-1 - Host mRNA ZNF254 http://www.ncbi.nlm.nih.gov/gene/9534 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007816 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-7-5p(miR-K7*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015217 BC-1 - Host mRNA CRKL http://www.ncbi.nlm.nih.gov/gene/1399 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007817 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-7-5p(miR-K7*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015217 BC-1 - Host mRNA UBE2F http://www.ncbi.nlm.nih.gov/gene/140739 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007818 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-7-5p(miR-K7*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015217 BC-1 - Host mRNA VAMP2 http://www.ncbi.nlm.nih.gov/gene/6844 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007819 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BCBL1 - Host mRNA BCLAF1 http://www.ncbi.nlm.nih.gov/gene/731605 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00007820 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA ATXN1L http://www.ncbi.nlm.nih.gov/gene/342371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007821 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA C4orf43 http://www.ncbi.nlm.nih.gov/gene/55319 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007822 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA CANT1 http://www.ncbi.nlm.nih.gov/gene/124583 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007823 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA ETV3 http://www.ncbi.nlm.nih.gov/gene/2117 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007824 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA FAM126B http://www.ncbi.nlm.nih.gov/gene/285172 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007825 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA FAM60A http://www.ncbi.nlm.nih.gov/gene/728592 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007826 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA GSK3B http://www.ncbi.nlm.nih.gov/gene/2932 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007827 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA HOXB7 http://www.ncbi.nlm.nih.gov/gene/3217 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007828 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA JARID2 http://www.ncbi.nlm.nih.gov/gene/3720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007829 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA MFN2 http://www.ncbi.nlm.nih.gov/gene/9927 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007830 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA MTPN http://www.ncbi.nlm.nih.gov/gene/767558 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007831 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA NPLOC4 http://www.ncbi.nlm.nih.gov/gene/55666 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007832 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA NUFIP2 http://www.ncbi.nlm.nih.gov/gene/57532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007833 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA PRICKLE4 http://www.ncbi.nlm.nih.gov/gene/29964 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007834 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA RPL27A http://www.ncbi.nlm.nih.gov/gene/6157 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007835 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA SFRS6 http://www.ncbi.nlm.nih.gov/gene/644422 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007836 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA SLC9A6 http://www.ncbi.nlm.nih.gov/gene/10479 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007837 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA SOLH http://www.ncbi.nlm.nih.gov/gene/6650 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007838 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA TLK1 http://www.ncbi.nlm.nih.gov/gene/9874 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007839 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA TMEM39A http://www.ncbi.nlm.nih.gov/gene/55254 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007840 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA UBN2 http://www.ncbi.nlm.nih.gov/gene/254048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007841 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA ZNF419 http://www.ncbi.nlm.nih.gov/gene/79744 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007842 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA ZNF462 http://www.ncbi.nlm.nih.gov/gene/58499 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007843 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-1 - Host mRNA ZNF644 http://www.ncbi.nlm.nih.gov/gene/84146 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007844 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-3 - Host mRNA ATXN1L http://www.ncbi.nlm.nih.gov/gene/342371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007845 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-3 - Host mRNA BST2 http://www.ncbi.nlm.nih.gov/gene/100129681 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007846 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-3 - Host mRNA CASP7 http://www.ncbi.nlm.nih.gov/gene/840 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007847 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-3 - Host mRNA DHX33 http://www.ncbi.nlm.nih.gov/gene/56919 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007848 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-3 - Host mRNA FAM60A http://www.ncbi.nlm.nih.gov/gene/728592 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007849 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-3 - Host mRNA GSK3B http://www.ncbi.nlm.nih.gov/gene/2932 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007850 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-3 - Host mRNA GTPBP10 http://www.ncbi.nlm.nih.gov/gene/85865 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007851 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-3 - Host mRNA KBTBD11 http://www.ncbi.nlm.nih.gov/gene/9920 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007852 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-3 - Host mRNA MFN2 http://www.ncbi.nlm.nih.gov/gene/9927 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007853 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-3 - Host mRNA NDUFA7 http://www.ncbi.nlm.nih.gov/gene/4701 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007854 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-3 - Host mRNA PRICKLE4 http://www.ncbi.nlm.nih.gov/gene/29964 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007855 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-3 - Host mRNA RCC1 http://www.ncbi.nlm.nih.gov/gene/1104 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007856 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-3 - Host mRNA RHOG http://www.ncbi.nlm.nih.gov/gene/391 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007857 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-3 - Host mRNA RPL27A http://www.ncbi.nlm.nih.gov/gene/6157 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007858 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-3 - Host mRNA SOLH http://www.ncbi.nlm.nih.gov/gene/6650 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007859 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-3 - Host mRNA TMEM39A http://www.ncbi.nlm.nih.gov/gene/55254 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007860 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-3 - Host mRNA UBN2 http://www.ncbi.nlm.nih.gov/gene/254048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007861 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-8-5p(miR-K8*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015216 BC-3 - Host mRNA ZNRF2 http://www.ncbi.nlm.nih.gov/gene/223082 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007862 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-3p(miR-K12-9-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002185 - - Host mRNA BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00007863 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA ACTR2 http://www.ncbi.nlm.nih.gov/gene/10097 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007864 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA ALS2 http://www.ncbi.nlm.nih.gov/gene/57679 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007865 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA AP1G1 http://www.ncbi.nlm.nih.gov/gene/164 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007866 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA CDKN1A http://www.ncbi.nlm.nih.gov/gene/1026 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007867 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA DCBLD2 http://www.ncbi.nlm.nih.gov/gene/131566 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007868 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA DHRS7B http://www.ncbi.nlm.nih.gov/gene/25979 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007869 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA FBXO11 http://www.ncbi.nlm.nih.gov/gene/80204 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007870 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA G3BP2 http://www.ncbi.nlm.nih.gov/gene/9908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007871 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA HIC2 http://www.ncbi.nlm.nih.gov/gene/23119 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007872 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA HNRNPF http://www.ncbi.nlm.nih.gov/gene/3185 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007873 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA HSPA1B http://www.ncbi.nlm.nih.gov/gene/3303 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007874 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA JAK3 http://www.ncbi.nlm.nih.gov/gene/3718 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007875 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA KBTBD8 http://www.ncbi.nlm.nih.gov/gene/84541 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007876 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA KIAA0232 http://www.ncbi.nlm.nih.gov/gene/9778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007877 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA KIAA0494 http://www.ncbi.nlm.nih.gov/gene/9813 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007878 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA LMBR1 http://www.ncbi.nlm.nih.gov/gene/64327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007879 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA LRMP http://www.ncbi.nlm.nih.gov/gene/4033 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007880 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA MAP3K7IP2 http://www.ncbi.nlm.nih.gov/gene/23118 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007881 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA MOCS3 http://www.ncbi.nlm.nih.gov/gene/27304 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007882 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA NT5DC3 http://www.ncbi.nlm.nih.gov/gene/51559 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007883 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA NUFIP2 http://www.ncbi.nlm.nih.gov/gene/57532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007884 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA NUP155 http://www.ncbi.nlm.nih.gov/gene/9631 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007885 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA PHF1 http://www.ncbi.nlm.nih.gov/gene/5252 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007886 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA POLR3A http://www.ncbi.nlm.nih.gov/gene/11128 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007887 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA RAB8B http://www.ncbi.nlm.nih.gov/gene/51762 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007888 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA SDCBP http://www.ncbi.nlm.nih.gov/gene/6386 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007889 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA SDF2 http://www.ncbi.nlm.nih.gov/gene/6388 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007890 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA SEC24C http://www.ncbi.nlm.nih.gov/gene/9632 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007891 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA SET http://www.ncbi.nlm.nih.gov/gene/646817 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007892 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA SFRS3 http://www.ncbi.nlm.nih.gov/gene/6428 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007893 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA SLC5A3 http://www.ncbi.nlm.nih.gov/gene/6526 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007894 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA SYNCRIP http://www.ncbi.nlm.nih.gov/gene/10492 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007895 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA TNFRSF10B http://www.ncbi.nlm.nih.gov/gene/8795 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007896 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA TSC22D1 http://www.ncbi.nlm.nih.gov/gene/8848 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007897 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA USP2 http://www.ncbi.nlm.nih.gov/gene/9099 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007898 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA VAMP3 http://www.ncbi.nlm.nih.gov/gene/9341 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007899 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA VOPP1 http://www.ncbi.nlm.nih.gov/gene/729086 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007900 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA ZSCAN12 http://www.ncbi.nlm.nih.gov/gene/9753 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007901 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 BC-1 - Host mRNA ZXDC http://www.ncbi.nlm.nih.gov/gene/79364 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007902 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 Primary effusion lymphoma (PEL) cell lines - Host Protein RTA http://www.ncbi.nlm.nih.gov/gene/116535 Downregulation 3'UTR indicator assays ,RIP-CHIP. 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00007903 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miRK9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 - - Host mRNA RTA http://www.ncbi.nlm.nih.gov/gene/116535 Downregulation Luciferase/RTA chimeric reporter. 20006845 Here we show that at least one of these miRNAs, miRK9*, targets a sequence in the 3' UTR of the mRNA encoding the major lytic switch protein (RTA), which controls reactivation from latency. Mutation of the recognition sequence in the RTA 3'UTR abolishes RTA downregulation by miRK9*.. VHID00007904 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 - - Host Protein RAD21 http://www.ncbi.nlm.nih.gov/gene/5885 - Ago-association data and motif detection, Preparation of small RNA libraries, Northern blot analysis, Luciferase assays, Real-time RT-PCR, Western blots, Immunoprecipitation and Northern blot analysis of Ago-RNA complexes. 19812168 We found that Kaposi sarcoma-associated herpesvirus K12-1 miRNA (23 bases) associates with a distinct, unusually small (17-base) RNA (usRNA) that can effectively downregulate a K12-1 miRNA target, human RAD21, suggesting that stable degradation-like products may also contribute to gene regulation. VHID00007905 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BCBL1 - Host mRNA CASP3 http://www.ncbi.nlm.nih.gov/gene/836 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00007906 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BCBL1 - Host mRNA RAD21 http://www.ncbi.nlm.nih.gov/gene/5885 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00007907 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BCBL1 - Host mRNA THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00007908 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ABHD10 http://www.ncbi.nlm.nih.gov/gene/55347 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007909 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ADO http://www.ncbi.nlm.nih.gov/gene/84890 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007910 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ANKRD44 http://www.ncbi.nlm.nih.gov/gene/91526 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007911 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ANLN http://www.ncbi.nlm.nih.gov/gene/54443 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007912 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ANXA5 http://www.ncbi.nlm.nih.gov/gene/308 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007913 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA AP1G1 http://www.ncbi.nlm.nih.gov/gene/164 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007914 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA AP1S1 http://www.ncbi.nlm.nih.gov/gene/1174 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007915 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA APC http://www.ncbi.nlm.nih.gov/gene/324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007916 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA APOM http://www.ncbi.nlm.nih.gov/gene/55937 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007917 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ARID1A http://www.ncbi.nlm.nih.gov/gene/8289 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007918 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ARL5A http://www.ncbi.nlm.nih.gov/gene/26225 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007919 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ARMC10 http://www.ncbi.nlm.nih.gov/gene/83787 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007920 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ARPP19 http://www.ncbi.nlm.nih.gov/gene/646227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007921 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ASXL2 http://www.ncbi.nlm.nih.gov/gene/55252 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007922 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ATL2 http://www.ncbi.nlm.nih.gov/gene/64225 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007923 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ATP11B http://www.ncbi.nlm.nih.gov/gene/23200 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007924 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ATP13A3 http://www.ncbi.nlm.nih.gov/gene/79572 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007925 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ATP6V1B2 http://www.ncbi.nlm.nih.gov/gene/526 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007926 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ATP9B http://www.ncbi.nlm.nih.gov/gene/374868 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007927 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA AXIN2 http://www.ncbi.nlm.nih.gov/gene/8313 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007928 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA BCL11A http://www.ncbi.nlm.nih.gov/gene/53335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007929 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA BCOR http://www.ncbi.nlm.nih.gov/gene/54880 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007930 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA BHLHB9 http://www.ncbi.nlm.nih.gov/gene/80823 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007931 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA BNIP2 http://www.ncbi.nlm.nih.gov/gene/663 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007932 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA BRWD3 http://www.ncbi.nlm.nih.gov/gene/254065 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007933 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA C11orf82 http://www.ncbi.nlm.nih.gov/gene/220042 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007934 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA C12orf35 http://www.ncbi.nlm.nih.gov/gene/55196 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007935 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA C13orf23 http://www.ncbi.nlm.nih.gov/gene/80209 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007936 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA C15orf23 http://www.ncbi.nlm.nih.gov/gene/90417 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007937 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA C16orf63 http://www.ncbi.nlm.nih.gov/gene/123811 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007938 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA C18orf25 http://www.ncbi.nlm.nih.gov/gene/147339 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007939 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA C1orf103 http://www.ncbi.nlm.nih.gov/gene/55791 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007940 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA C1orf107 http://www.ncbi.nlm.nih.gov/gene/27042 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007941 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA C1orf77 http://www.ncbi.nlm.nih.gov/gene/26097 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007942 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA C2orf37 http://www.ncbi.nlm.nih.gov/gene/80067 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007943 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA C3orf64 http://www.ncbi.nlm.nih.gov/gene/285203 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007944 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA C5orf44 http://www.ncbi.nlm.nih.gov/gene/80006 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007945 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA C6orf167 http://www.ncbi.nlm.nih.gov/gene/253714 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007946 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA C7orf42 http://www.ncbi.nlm.nih.gov/gene/55069 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007947 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA C7orf60 http://www.ncbi.nlm.nih.gov/gene/154743 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007948 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CALCRL http://www.ncbi.nlm.nih.gov/gene/10203 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007949 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CALM1 http://www.ncbi.nlm.nih.gov/gene/808 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007950 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CALM3 http://www.ncbi.nlm.nih.gov/gene/808 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007951 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CASP3 http://www.ncbi.nlm.nih.gov/gene/836 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007952 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CAST http://www.ncbi.nlm.nih.gov/gene/831 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007953 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CBL http://www.ncbi.nlm.nih.gov/gene/867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007954 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CCDC82 http://www.ncbi.nlm.nih.gov/gene/79780 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007955 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CCND2 http://www.ncbi.nlm.nih.gov/gene/894 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007956 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007957 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CD164 http://www.ncbi.nlm.nih.gov/gene/8763 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007958 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CD47 http://www.ncbi.nlm.nih.gov/gene/961 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007959 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CDC2L6 http://www.ncbi.nlm.nih.gov/gene/23097 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007960 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CDKN1A http://www.ncbi.nlm.nih.gov/gene/1026 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007961 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CDR2 http://www.ncbi.nlm.nih.gov/gene/1039 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007962 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CHD9 http://www.ncbi.nlm.nih.gov/gene/80205 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007963 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CHRAC1 http://www.ncbi.nlm.nih.gov/gene/54108 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007964 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CLDN12 http://www.ncbi.nlm.nih.gov/gene/9069 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007965 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CNOT3 http://www.ncbi.nlm.nih.gov/gene/4849 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007966 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CNP http://www.ncbi.nlm.nih.gov/gene/1267 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007967 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA COMMD7 http://www.ncbi.nlm.nih.gov/gene/149951 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007968 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA COPS5 http://www.ncbi.nlm.nih.gov/gene/10987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007969 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA COX5B http://www.ncbi.nlm.nih.gov/gene/1329 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007970 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CPEB4 http://www.ncbi.nlm.nih.gov/gene/80315 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007971 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CPNE3 http://www.ncbi.nlm.nih.gov/gene/8895 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007972 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CRKL http://www.ncbi.nlm.nih.gov/gene/1399 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007973 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CSPP1 http://www.ncbi.nlm.nih.gov/gene/79848 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007974 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CTNNB1 http://www.ncbi.nlm.nih.gov/gene/1499 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007975 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA CWC15 http://www.ncbi.nlm.nih.gov/gene/51503 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007976 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA DCBLD2 http://www.ncbi.nlm.nih.gov/gene/131566 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007977 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA DCP2 http://www.ncbi.nlm.nih.gov/gene/167227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007978 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA DCTN4 http://www.ncbi.nlm.nih.gov/gene/51164 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007979 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA DDX46 http://www.ncbi.nlm.nih.gov/gene/9879 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007980 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA DDX47 http://www.ncbi.nlm.nih.gov/gene/51202 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007981 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA DECR2 http://www.ncbi.nlm.nih.gov/gene/26063 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007982 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA DNAJA1 http://www.ncbi.nlm.nih.gov/gene/3301 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007983 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA DUSP1 http://www.ncbi.nlm.nih.gov/gene/1843 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007984 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA DUSP16 http://www.ncbi.nlm.nih.gov/gene/80824 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007985 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA E2F7 http://www.ncbi.nlm.nih.gov/gene/144455 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007986 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA EIF2C4 http://www.ncbi.nlm.nih.gov/gene/192670 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007987 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ELF1 http://www.ncbi.nlm.nih.gov/gene/1997 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007988 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA EPC1 http://www.ncbi.nlm.nih.gov/gene/80314 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007989 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA EPN2 http://www.ncbi.nlm.nih.gov/gene/22905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007990 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA EPS15 http://www.ncbi.nlm.nih.gov/gene/2060 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007991 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ERP44 http://www.ncbi.nlm.nih.gov/gene/23071 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007992 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ETNK1 http://www.ncbi.nlm.nih.gov/gene/55500 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007993 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ETV1 http://www.ncbi.nlm.nih.gov/gene/2115 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007994 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA FAM103A1 http://www.ncbi.nlm.nih.gov/gene/83640 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007995 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA FAM107B http://www.ncbi.nlm.nih.gov/gene/83641 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007996 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA FAM114A2 http://www.ncbi.nlm.nih.gov/gene/10827 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007997 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA FAM175A http://www.ncbi.nlm.nih.gov/gene/84142 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007998 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA FAM178A http://www.ncbi.nlm.nih.gov/gene/55719 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00007999 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA FAM96A http://www.ncbi.nlm.nih.gov/gene/84191 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008000 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA FEM1B http://www.ncbi.nlm.nih.gov/gene/10116 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008001 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA FNDC3A http://www.ncbi.nlm.nih.gov/gene/22862 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008002 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA FNDC3B http://www.ncbi.nlm.nih.gov/gene/64778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008003 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA FOXK1 http://www.ncbi.nlm.nih.gov/gene/221937 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008004 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA FOXN2 http://www.ncbi.nlm.nih.gov/gene/3344 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008005 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA FRMD6 http://www.ncbi.nlm.nih.gov/gene/122786 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008006 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA FZD6 http://www.ncbi.nlm.nih.gov/gene/8323 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008007 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA GBP4 http://www.ncbi.nlm.nih.gov/gene/115361 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008008 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA GCLM http://www.ncbi.nlm.nih.gov/gene/2730 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008009 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA GIT2 http://www.ncbi.nlm.nih.gov/gene/9815 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008010 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA GK5 http://www.ncbi.nlm.nih.gov/gene/256356 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008011 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA GLCCI1 http://www.ncbi.nlm.nih.gov/gene/113263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008012 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA GNB1 http://www.ncbi.nlm.nih.gov/gene/2782 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008013 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA GOPC http://www.ncbi.nlm.nih.gov/gene/57120 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008014 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA GORASP2 http://www.ncbi.nlm.nih.gov/gene/26003 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008015 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA GPATCH2 http://www.ncbi.nlm.nih.gov/gene/55105 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008016 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA GRAMD4 http://www.ncbi.nlm.nih.gov/gene/23151 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008017 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA GTF2H1 http://www.ncbi.nlm.nih.gov/gene/2965 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008018 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA GTPBP8 http://www.ncbi.nlm.nih.gov/gene/29083 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008019 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA GYPE http://www.ncbi.nlm.nih.gov/gene/2996 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008020 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA HDAC2 http://www.ncbi.nlm.nih.gov/gene/3066 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008021 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA HECTD1 http://www.ncbi.nlm.nih.gov/gene/25831 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008022 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA HELLS http://www.ncbi.nlm.nih.gov/gene/3070 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008023 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA HIF1A http://www.ncbi.nlm.nih.gov/gene/3091 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008024 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA HMGXB4 http://www.ncbi.nlm.nih.gov/gene/10042 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008025 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA HNRNPA2B1 http://www.ncbi.nlm.nih.gov/gene/3181 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008026 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA HNRNPU http://www.ncbi.nlm.nih.gov/gene/3192 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008027 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA HS3ST3B1 http://www.ncbi.nlm.nih.gov/gene/9953 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008028 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA IDE http://www.ncbi.nlm.nih.gov/gene/3416 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008029 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA IDS http://www.ncbi.nlm.nih.gov/gene/3423 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008030 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA IFT140 http://www.ncbi.nlm.nih.gov/gene/9742 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008031 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA IL16 http://www.ncbi.nlm.nih.gov/gene/3603 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008032 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA IPO7 http://www.ncbi.nlm.nih.gov/gene/10527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008033 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA IRF4 http://www.ncbi.nlm.nih.gov/gene/3662 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008034 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA KDM5A http://www.ncbi.nlm.nih.gov/gene/5927 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008035 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA KIAA0513 http://www.ncbi.nlm.nih.gov/gene/9764 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008036 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA KIAA1012 http://www.ncbi.nlm.nih.gov/gene/22878 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008037 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA KIAA2018 http://www.ncbi.nlm.nih.gov/gene/205717 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008038 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA KIF1B http://www.ncbi.nlm.nih.gov/gene/23095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008039 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA KLF12 http://www.ncbi.nlm.nih.gov/gene/11278 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008040 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA KLHDC10 http://www.ncbi.nlm.nih.gov/gene/23008 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008041 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA KLHDC2 http://www.ncbi.nlm.nih.gov/gene/23588 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008042 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA KLHDC5 http://www.ncbi.nlm.nih.gov/gene/57542 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008043 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA KLHL18 http://www.ncbi.nlm.nih.gov/gene/23276 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008044 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA KPNA1 http://www.ncbi.nlm.nih.gov/gene/3836 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008045 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA KPNA4 http://www.ncbi.nlm.nih.gov/gene/3840 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008046 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA KPNA6 http://www.ncbi.nlm.nih.gov/gene/23633 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008047 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA KTELC1 http://www.ncbi.nlm.nih.gov/gene/56983 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008048 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA LARP4B http://www.ncbi.nlm.nih.gov/gene/23185 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008049 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA LBR http://www.ncbi.nlm.nih.gov/gene/3930 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008050 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA LIMD1 http://www.ncbi.nlm.nih.gov/gene/8994 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008051 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA LSM14B http://www.ncbi.nlm.nih.gov/gene/149986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008052 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA LYN http://www.ncbi.nlm.nih.gov/gene/4067 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008053 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA LYPLA1 http://www.ncbi.nlm.nih.gov/gene/10434 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008054 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA LYSMD1 http://www.ncbi.nlm.nih.gov/gene/388695 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008055 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA LZIC http://www.ncbi.nlm.nih.gov/gene/84328 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008056 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MAGOHB http://www.ncbi.nlm.nih.gov/gene/55110 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008057 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MAP3K7IP3 http://www.ncbi.nlm.nih.gov/gene/257397 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008058 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MBD2 http://www.ncbi.nlm.nih.gov/gene/8932 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008059 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MBP http://www.ncbi.nlm.nih.gov/gene/4155 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008060 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MBTPS2 http://www.ncbi.nlm.nih.gov/gene/51360 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008061 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MDM2 http://www.ncbi.nlm.nih.gov/gene/4193 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008062 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MECP2 http://www.ncbi.nlm.nih.gov/gene/4204 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008063 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MEF2C http://www.ncbi.nlm.nih.gov/gene/4208 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008064 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MEX3C http://www.ncbi.nlm.nih.gov/gene/51320 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008065 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MKL2 http://www.ncbi.nlm.nih.gov/gene/57496 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008066 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MKRN1 http://www.ncbi.nlm.nih.gov/gene/23608 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008067 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MLL http://www.ncbi.nlm.nih.gov/gene/4297 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008068 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MLLT10 http://www.ncbi.nlm.nih.gov/gene/8028 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008069 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MORF4L2 http://www.ncbi.nlm.nih.gov/gene/9643 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008070 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MPP6 http://www.ncbi.nlm.nih.gov/gene/51678 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008071 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MPPE1 http://www.ncbi.nlm.nih.gov/gene/65258 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008072 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MRPL34 http://www.ncbi.nlm.nih.gov/gene/64981 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008073 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MTDH http://www.ncbi.nlm.nih.gov/gene/92140 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008074 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MTG1 http://www.ncbi.nlm.nih.gov/gene/92170 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008075 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MTMR2 http://www.ncbi.nlm.nih.gov/gene/8898 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008076 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MTPN http://www.ncbi.nlm.nih.gov/gene/767558 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008077 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MTUS1 http://www.ncbi.nlm.nih.gov/gene/57509 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008078 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA MTX3 http://www.ncbi.nlm.nih.gov/gene/345778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008079 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA NAF1 http://www.ncbi.nlm.nih.gov/gene/92345 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008080 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA NCOA3 http://www.ncbi.nlm.nih.gov/gene/8202 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008081 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA NCOR1 http://www.ncbi.nlm.nih.gov/gene/9611 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008082 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA NDFIP1 http://www.ncbi.nlm.nih.gov/gene/80762 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008083 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA NDFIP2 http://www.ncbi.nlm.nih.gov/gene/54602 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008084 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA NFAT5 http://www.ncbi.nlm.nih.gov/gene/10725 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008085 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA NFE2L2 http://www.ncbi.nlm.nih.gov/gene/4780 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008086 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA NMI http://www.ncbi.nlm.nih.gov/gene/9111 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008087 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA NR1D2 http://www.ncbi.nlm.nih.gov/gene/9975 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008088 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA NR3C1 http://www.ncbi.nlm.nih.gov/gene/2908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008089 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA NT5DC1 http://www.ncbi.nlm.nih.gov/gene/221294 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008090 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA NUDT5 http://www.ncbi.nlm.nih.gov/gene/11164 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008091 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA NUFIP2 http://www.ncbi.nlm.nih.gov/gene/57532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008092 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA NUP205 http://www.ncbi.nlm.nih.gov/gene/23165 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008093 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA NUP43 http://www.ncbi.nlm.nih.gov/gene/348995 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008094 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA OGT http://www.ncbi.nlm.nih.gov/gene/8473 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008095 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA OPN3 http://www.ncbi.nlm.nih.gov/gene/23596 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008096 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA OTUD3 http://www.ncbi.nlm.nih.gov/gene/23252 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008097 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA OXR1 http://www.ncbi.nlm.nih.gov/gene/55074 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008098 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PACRGL http://www.ncbi.nlm.nih.gov/gene/133015 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008099 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PAFAH1B1 http://www.ncbi.nlm.nih.gov/gene/5048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008100 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PAPD5 http://www.ncbi.nlm.nih.gov/gene/64282 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008101 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PBRM1 http://www.ncbi.nlm.nih.gov/gene/55193 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008102 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PCNX http://www.ncbi.nlm.nih.gov/gene/22990 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008103 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PDE4D http://www.ncbi.nlm.nih.gov/gene/5144 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008104 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PDE7A http://www.ncbi.nlm.nih.gov/gene/5150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008105 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PDIK1L http://www.ncbi.nlm.nih.gov/gene/149420 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008106 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PER2 http://www.ncbi.nlm.nih.gov/gene/8864 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008107 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PEX11B http://www.ncbi.nlm.nih.gov/gene/8799 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008108 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PHF3 http://www.ncbi.nlm.nih.gov/gene/23469 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008109 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PIP5K1C http://www.ncbi.nlm.nih.gov/gene/23396 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008110 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PLCXD2 http://www.ncbi.nlm.nih.gov/gene/90102 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008111 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA POLS http://www.ncbi.nlm.nih.gov/gene/11044 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008112 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA POU2F1 http://www.ncbi.nlm.nih.gov/gene/5451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008113 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PPM1K http://www.ncbi.nlm.nih.gov/gene/152926 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008114 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PPP1R15B http://www.ncbi.nlm.nih.gov/gene/84919 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008115 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PPP1R8 http://www.ncbi.nlm.nih.gov/gene/5511 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008116 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PPP2CA http://www.ncbi.nlm.nih.gov/gene/5515 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008117 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PRDM15 http://www.ncbi.nlm.nih.gov/gene/63977 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008118 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PROK2 http://www.ncbi.nlm.nih.gov/gene/60675 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008119 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PSAT1 http://www.ncbi.nlm.nih.gov/gene/137133 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008120 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PTPN13 http://www.ncbi.nlm.nih.gov/gene/5783 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008121 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PUM2 http://www.ncbi.nlm.nih.gov/gene/23369 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008122 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PURB http://www.ncbi.nlm.nih.gov/gene/5814 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008123 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA PXT1 http://www.ncbi.nlm.nih.gov/gene/222659 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008124 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RAB3GAP2 http://www.ncbi.nlm.nih.gov/gene/25782 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008125 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RABEP1 http://www.ncbi.nlm.nih.gov/gene/9135 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008126 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RABL5 http://www.ncbi.nlm.nih.gov/gene/64792 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008127 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RAD21 http://www.ncbi.nlm.nih.gov/gene/5885 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008128 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RAD23B http://www.ncbi.nlm.nih.gov/gene/5887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008129 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RALGPS1 http://www.ncbi.nlm.nih.gov/gene/9649 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008130 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RANBP9 http://www.ncbi.nlm.nih.gov/gene/10048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008131 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RAPGEF2 http://www.ncbi.nlm.nih.gov/gene/9693 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008132 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RAPH1 http://www.ncbi.nlm.nih.gov/gene/65059 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008133 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RBAK http://www.ncbi.nlm.nih.gov/gene/389458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008134 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RBM22 http://www.ncbi.nlm.nih.gov/gene/55696 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008135 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RBM27 http://www.ncbi.nlm.nih.gov/gene/54439 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008136 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RBPSUH http://www.ncbi.nlm.nih.gov/gene/3516 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008137 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RC3H1 http://www.ncbi.nlm.nih.gov/gene/149041 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008138 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RFX7 http://www.ncbi.nlm.nih.gov/gene/64864 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008139 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RFXAP http://www.ncbi.nlm.nih.gov/gene/5994 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008140 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RLIM http://www.ncbi.nlm.nih.gov/gene/51132 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008141 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RNF160 http://www.ncbi.nlm.nih.gov/gene/26046 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008142 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RORA http://www.ncbi.nlm.nih.gov/gene/6095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008143 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RPE http://www.ncbi.nlm.nih.gov/gene/729020 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008144 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RPL7L1 http://www.ncbi.nlm.nih.gov/gene/285855 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008145 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RRAGC http://www.ncbi.nlm.nih.gov/gene/64121 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008146 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RSF1 http://www.ncbi.nlm.nih.gov/gene/51773 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008147 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA RYBP http://www.ncbi.nlm.nih.gov/gene/23429 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008148 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SCARB2 http://www.ncbi.nlm.nih.gov/gene/950 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008149 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SEC14L1 http://www.ncbi.nlm.nih.gov/gene/6397 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008150 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SERP1 http://www.ncbi.nlm.nih.gov/gene/27230 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008151 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SF3A3 http://www.ncbi.nlm.nih.gov/gene/10946 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008152 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SFRS11 http://www.ncbi.nlm.nih.gov/gene/9295 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008153 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SFRS18 http://www.ncbi.nlm.nih.gov/gene/25957 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008154 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SGK3 http://www.ncbi.nlm.nih.gov/gene/23678 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008155 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SH3BP2 http://www.ncbi.nlm.nih.gov/gene/6452 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008156 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SLC16A1 http://www.ncbi.nlm.nih.gov/gene/6566 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008157 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SLC19A2 http://www.ncbi.nlm.nih.gov/gene/10560 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008158 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SLC30A7 http://www.ncbi.nlm.nih.gov/gene/148867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008159 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SLTM http://www.ncbi.nlm.nih.gov/gene/79811 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008160 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SMAD4 http://www.ncbi.nlm.nih.gov/gene/4089 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008161 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SNN http://www.ncbi.nlm.nih.gov/gene/8303 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008162 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SNTB2 http://www.ncbi.nlm.nih.gov/gene/6645 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008163 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SNX16 http://www.ncbi.nlm.nih.gov/gene/64089 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008164 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SOCS5 http://www.ncbi.nlm.nih.gov/gene/9655 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008165 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SOCS6 http://www.ncbi.nlm.nih.gov/gene/9306 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008166 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SOLH http://www.ncbi.nlm.nih.gov/gene/6650 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008167 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SP3 http://www.ncbi.nlm.nih.gov/gene/6670 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008168 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SPAG1 http://www.ncbi.nlm.nih.gov/gene/6674 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008169 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SPSB1 http://www.ncbi.nlm.nih.gov/gene/80176 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008170 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SRP54 http://www.ncbi.nlm.nih.gov/gene/650638 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008171 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SRXN1 http://www.ncbi.nlm.nih.gov/gene/140809 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008172 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA STK17A http://www.ncbi.nlm.nih.gov/gene/9263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008173 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA STX12 http://www.ncbi.nlm.nih.gov/gene/23673 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008174 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA STX16 http://www.ncbi.nlm.nih.gov/gene/8675 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008175 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA SUMO3 http://www.ncbi.nlm.nih.gov/gene/285829 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008176 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TANC2 http://www.ncbi.nlm.nih.gov/gene/26115 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008177 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TCF4 http://www.ncbi.nlm.nih.gov/gene/6925 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008178 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TET3 http://www.ncbi.nlm.nih.gov/gene/200424 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008179 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TFAP4 http://www.ncbi.nlm.nih.gov/gene/7023 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008180 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TGIF2 http://www.ncbi.nlm.nih.gov/gene/60436 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008181 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA THAP1 http://www.ncbi.nlm.nih.gov/gene/55145 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008182 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TM7SF3 http://www.ncbi.nlm.nih.gov/gene/51768 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008183 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TMEM181 http://www.ncbi.nlm.nih.gov/gene/57583 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008184 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TMEM192 http://www.ncbi.nlm.nih.gov/gene/201931 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008185 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TNFRSF10B http://www.ncbi.nlm.nih.gov/gene/8795 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008186 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TNRC6B http://www.ncbi.nlm.nih.gov/gene/23112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008187 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TOMM20 http://www.ncbi.nlm.nih.gov/gene/100129272 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008188 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TRIO http://www.ncbi.nlm.nih.gov/gene/7204 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008189 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TRMT61B http://www.ncbi.nlm.nih.gov/gene/55006 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008190 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TROVE2 http://www.ncbi.nlm.nih.gov/gene/6738 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008191 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TSHZ1 http://www.ncbi.nlm.nih.gov/gene/10194 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008192 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TSR1 http://www.ncbi.nlm.nih.gov/gene/55720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008193 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TTC35 http://www.ncbi.nlm.nih.gov/gene/9694 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008194 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TTLL11 http://www.ncbi.nlm.nih.gov/gene/158135 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008195 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TUBA1B http://www.ncbi.nlm.nih.gov/gene/10376 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008196 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TUBA1C http://www.ncbi.nlm.nih.gov/gene/84790 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008197 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TXLNA http://www.ncbi.nlm.nih.gov/gene/200081 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008198 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA TXNDC9 http://www.ncbi.nlm.nih.gov/gene/10190 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008199 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA UBA5 http://www.ncbi.nlm.nih.gov/gene/79876 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008200 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA UBA6 http://www.ncbi.nlm.nih.gov/gene/55236 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008201 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA UBE2D1 http://www.ncbi.nlm.nih.gov/gene/7321 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008202 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA UBE2F http://www.ncbi.nlm.nih.gov/gene/140739 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008203 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA UBE2K http://www.ncbi.nlm.nih.gov/gene/3093 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008204 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA UBL3 http://www.ncbi.nlm.nih.gov/gene/5412 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008205 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA UNC119B http://www.ncbi.nlm.nih.gov/gene/84747 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008206 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA USP3 http://www.ncbi.nlm.nih.gov/gene/9960 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008207 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA USP33 http://www.ncbi.nlm.nih.gov/gene/23032 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008208 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA UTP15 http://www.ncbi.nlm.nih.gov/gene/84135 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008209 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA VANGL1 http://www.ncbi.nlm.nih.gov/gene/81839 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008210 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA VEZT http://www.ncbi.nlm.nih.gov/gene/55591 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008211 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA WASL http://www.ncbi.nlm.nih.gov/gene/8976 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008212 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA WBP11 http://www.ncbi.nlm.nih.gov/gene/51729 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008213 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA WEE1 http://www.ncbi.nlm.nih.gov/gene/7465 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008214 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA XPO1 http://www.ncbi.nlm.nih.gov/gene/7514 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008215 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA YIPF5 http://www.ncbi.nlm.nih.gov/gene/81555 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008216 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA YOD1 http://www.ncbi.nlm.nih.gov/gene/55432 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008217 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA YY1 http://www.ncbi.nlm.nih.gov/gene/7528 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008218 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZBTB1 http://www.ncbi.nlm.nih.gov/gene/22890 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008219 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZBTB33 http://www.ncbi.nlm.nih.gov/gene/10009 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008220 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZBTB39 http://www.ncbi.nlm.nih.gov/gene/9880 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008221 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZFP36L2 http://www.ncbi.nlm.nih.gov/gene/678 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008222 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZFP91 http://www.ncbi.nlm.nih.gov/gene/386607 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008223 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZFYVE20 http://www.ncbi.nlm.nih.gov/gene/64145 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008224 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZHX3 http://www.ncbi.nlm.nih.gov/gene/23051 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008225 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZIC2 http://www.ncbi.nlm.nih.gov/gene/7546 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008226 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZMYM2 http://www.ncbi.nlm.nih.gov/gene/7750 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008227 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZNF124 http://www.ncbi.nlm.nih.gov/gene/7678 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008228 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZNF146 http://www.ncbi.nlm.nih.gov/gene/7705 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008229 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZNF148 http://www.ncbi.nlm.nih.gov/gene/7707 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008230 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZNF217 http://www.ncbi.nlm.nih.gov/gene/7764 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008231 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZNF238 http://www.ncbi.nlm.nih.gov/gene/10472 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008232 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZNF276 http://www.ncbi.nlm.nih.gov/gene/92822 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008233 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZNF317 http://www.ncbi.nlm.nih.gov/gene/57693 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008234 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZNF367 http://www.ncbi.nlm.nih.gov/gene/195828 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008235 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZNF426 http://www.ncbi.nlm.nih.gov/gene/79088 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008236 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZNF451 http://www.ncbi.nlm.nih.gov/gene/26036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008237 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZNF498 http://www.ncbi.nlm.nih.gov/gene/221785 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008238 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZNF517 http://www.ncbi.nlm.nih.gov/gene/340385 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008239 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZNF561 http://www.ncbi.nlm.nih.gov/gene/729648 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008240 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZNF654 http://www.ncbi.nlm.nih.gov/gene/55279 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008241 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZNF678 http://www.ncbi.nlm.nih.gov/gene/339500 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008242 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZNF696 http://www.ncbi.nlm.nih.gov/gene/79943 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008243 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZNF740 http://www.ncbi.nlm.nih.gov/gene/283337 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008244 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZNF828 http://www.ncbi.nlm.nih.gov/gene/283489 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008245 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZNFX1 http://www.ncbi.nlm.nih.gov/gene/57169 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008246 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-1 - Host mRNA ZSCAN29 http://www.ncbi.nlm.nih.gov/gene/146050 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008247 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ABHD10 http://www.ncbi.nlm.nih.gov/gene/55347 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008248 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ADO http://www.ncbi.nlm.nih.gov/gene/84890 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008249 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA AEN http://www.ncbi.nlm.nih.gov/gene/64782 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008250 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA AFF1 http://www.ncbi.nlm.nih.gov/gene/4299 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008251 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ANKRD17 http://www.ncbi.nlm.nih.gov/gene/26057 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008252 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ANLN http://www.ncbi.nlm.nih.gov/gene/54443 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008253 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ANXA5 http://www.ncbi.nlm.nih.gov/gene/308 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008254 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA AP1G1 http://www.ncbi.nlm.nih.gov/gene/164 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008255 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA AP1S1 http://www.ncbi.nlm.nih.gov/gene/1174 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008256 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ARID1A http://www.ncbi.nlm.nih.gov/gene/8289 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008257 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ARL6IP6 http://www.ncbi.nlm.nih.gov/gene/151188 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008258 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ARMC10 http://www.ncbi.nlm.nih.gov/gene/83787 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008259 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ARPC5 http://www.ncbi.nlm.nih.gov/gene/10092 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008260 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ARPP19 http://www.ncbi.nlm.nih.gov/gene/646227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008261 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ATP11B http://www.ncbi.nlm.nih.gov/gene/23200 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008262 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ATXN7L1 http://www.ncbi.nlm.nih.gov/gene/222255 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008263 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA AXIN2 http://www.ncbi.nlm.nih.gov/gene/8313 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008264 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA BCOR http://www.ncbi.nlm.nih.gov/gene/54880 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008265 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA BDP1 http://www.ncbi.nlm.nih.gov/gene/55814 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008266 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA C11orf30 http://www.ncbi.nlm.nih.gov/gene/56946 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008267 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA C11orf82 http://www.ncbi.nlm.nih.gov/gene/220042 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008268 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA C12orf35 http://www.ncbi.nlm.nih.gov/gene/55196 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008269 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA C13orf23 http://www.ncbi.nlm.nih.gov/gene/80209 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008270 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA C15orf23 http://www.ncbi.nlm.nih.gov/gene/90417 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008271 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA C1orf103 http://www.ncbi.nlm.nih.gov/gene/55791 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008272 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA C2orf37 http://www.ncbi.nlm.nih.gov/gene/80067 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008273 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA C5orf44 http://www.ncbi.nlm.nih.gov/gene/80006 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008274 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA C7orf60 http://www.ncbi.nlm.nih.gov/gene/154743 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008275 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA C9orf91 http://www.ncbi.nlm.nih.gov/gene/203197 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008276 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA CALCRL http://www.ncbi.nlm.nih.gov/gene/10203 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008277 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA CALM1 http://www.ncbi.nlm.nih.gov/gene/808 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008278 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA CALM3 http://www.ncbi.nlm.nih.gov/gene/808 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008279 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA CCDC82 http://www.ncbi.nlm.nih.gov/gene/79780 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008280 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA CCND2 http://www.ncbi.nlm.nih.gov/gene/894 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008281 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA CD164 http://www.ncbi.nlm.nih.gov/gene/8763 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008282 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA CD59 http://www.ncbi.nlm.nih.gov/gene/966 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008283 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA CDC2 http://www.ncbi.nlm.nih.gov/gene/983 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008284 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA CDC2L6 http://www.ncbi.nlm.nih.gov/gene/23097 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008285 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA CDH2 http://www.ncbi.nlm.nih.gov/gene/1000 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008286 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA CDK5R1 http://www.ncbi.nlm.nih.gov/gene/8851 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008287 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA CDKN1A http://www.ncbi.nlm.nih.gov/gene/1026 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008288 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA CDR2 http://www.ncbi.nlm.nih.gov/gene/1039 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008289 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA CHD9 http://www.ncbi.nlm.nih.gov/gene/80205 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008290 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA CLDN12 http://www.ncbi.nlm.nih.gov/gene/9069 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008291 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA CNP http://www.ncbi.nlm.nih.gov/gene/1267 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008292 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA COL4A3BP http://www.ncbi.nlm.nih.gov/gene/10087 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008293 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA COMMD7 http://www.ncbi.nlm.nih.gov/gene/149951 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008294 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA COPS5 http://www.ncbi.nlm.nih.gov/gene/10987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008295 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA CPEB2 http://www.ncbi.nlm.nih.gov/gene/132864 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008296 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA CPNE3 http://www.ncbi.nlm.nih.gov/gene/8895 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008297 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA CSPP1 http://www.ncbi.nlm.nih.gov/gene/79848 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008298 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA CWC15 http://www.ncbi.nlm.nih.gov/gene/51503 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008299 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA DCBLD2 http://www.ncbi.nlm.nih.gov/gene/131566 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008300 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA DCP2 http://www.ncbi.nlm.nih.gov/gene/167227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008301 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA DCTN4 http://www.ncbi.nlm.nih.gov/gene/51164 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008302 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA DDX46 http://www.ncbi.nlm.nih.gov/gene/9879 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008303 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA DNAJA1 http://www.ncbi.nlm.nih.gov/gene/3301 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008304 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA DUSP1 http://www.ncbi.nlm.nih.gov/gene/1843 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008305 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA DUSP16 http://www.ncbi.nlm.nih.gov/gene/80824 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008306 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA EIF1AX http://www.ncbi.nlm.nih.gov/gene/1964 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008307 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA EIF2C4 http://www.ncbi.nlm.nih.gov/gene/192670 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008308 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA EMB http://www.ncbi.nlm.nih.gov/gene/133418 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008309 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA EPB41L2 http://www.ncbi.nlm.nih.gov/gene/2037 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008310 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA EPS15 http://www.ncbi.nlm.nih.gov/gene/2060 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008311 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ERP44 http://www.ncbi.nlm.nih.gov/gene/23071 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008312 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ETNK1 http://www.ncbi.nlm.nih.gov/gene/55500 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008313 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ETV1 http://www.ncbi.nlm.nih.gov/gene/2115 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008314 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA EXOC5 http://www.ncbi.nlm.nih.gov/gene/10640 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008315 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA EXOC6 http://www.ncbi.nlm.nih.gov/gene/54536 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008316 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA FAM103A1 http://www.ncbi.nlm.nih.gov/gene/83640 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008317 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA FAM107B http://www.ncbi.nlm.nih.gov/gene/83641 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008318 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA FAM175A http://www.ncbi.nlm.nih.gov/gene/84142 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008319 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA FAM178A http://www.ncbi.nlm.nih.gov/gene/55719 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008320 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA FAM59A http://www.ncbi.nlm.nih.gov/gene/64762 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008321 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA FAM96A http://www.ncbi.nlm.nih.gov/gene/84191 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008322 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA FBXO11 http://www.ncbi.nlm.nih.gov/gene/80204 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008323 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA FIGNL1 http://www.ncbi.nlm.nih.gov/gene/63979 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008324 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA FOXK1 http://www.ncbi.nlm.nih.gov/gene/221937 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008325 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA FOXN2 http://www.ncbi.nlm.nih.gov/gene/3344 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008326 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA FRMD6 http://www.ncbi.nlm.nih.gov/gene/122786 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008327 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA FZD6 http://www.ncbi.nlm.nih.gov/gene/8323 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008328 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA GATA3 http://www.ncbi.nlm.nih.gov/gene/2625 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008329 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA GATAD1 http://www.ncbi.nlm.nih.gov/gene/57798 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008330 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA GBP4 http://www.ncbi.nlm.nih.gov/gene/115361 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008331 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA GCLM http://www.ncbi.nlm.nih.gov/gene/2730 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008332 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA GCNT2 http://www.ncbi.nlm.nih.gov/gene/2651 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008333 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA GLCCI1 http://www.ncbi.nlm.nih.gov/gene/113263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008334 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA GNAI1 http://www.ncbi.nlm.nih.gov/gene/2770 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008335 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA GNB1 http://www.ncbi.nlm.nih.gov/gene/2782 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008336 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA GORASP2 http://www.ncbi.nlm.nih.gov/gene/26003 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008337 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA GRAMD4 http://www.ncbi.nlm.nih.gov/gene/23151 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008338 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA GRPEL2 http://www.ncbi.nlm.nih.gov/gene/134266 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008339 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA GTF2F2 http://www.ncbi.nlm.nih.gov/gene/2963 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008340 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA GTF2H1 http://www.ncbi.nlm.nih.gov/gene/2965 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008341 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA HDDC2 http://www.ncbi.nlm.nih.gov/gene/51020 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008342 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA HECTD1 http://www.ncbi.nlm.nih.gov/gene/25831 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008343 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA HELLS http://www.ncbi.nlm.nih.gov/gene/3070 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008344 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA HMGXB4 http://www.ncbi.nlm.nih.gov/gene/10042 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008345 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA HNRNPU http://www.ncbi.nlm.nih.gov/gene/3192 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008346 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA HS2ST1 http://www.ncbi.nlm.nih.gov/gene/9653 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008347 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA IDE http://www.ncbi.nlm.nih.gov/gene/3416 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008348 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA IL16 http://www.ncbi.nlm.nih.gov/gene/3603 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008349 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA IL6ST http://www.ncbi.nlm.nih.gov/gene/3572 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008350 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA IPO7 http://www.ncbi.nlm.nih.gov/gene/10527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008351 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA IRF4 http://www.ncbi.nlm.nih.gov/gene/3662 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008352 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA KBTBD11 http://www.ncbi.nlm.nih.gov/gene/9920 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008353 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA KCNK2 http://www.ncbi.nlm.nih.gov/gene/3776 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008354 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA KDM5A http://www.ncbi.nlm.nih.gov/gene/5927 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008355 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA KIAA1012 http://www.ncbi.nlm.nih.gov/gene/22878 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008356 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA KIAA2018 http://www.ncbi.nlm.nih.gov/gene/205717 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008357 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA KLF12 http://www.ncbi.nlm.nih.gov/gene/11278 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008358 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA KLHDC10 http://www.ncbi.nlm.nih.gov/gene/23008 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008359 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA KLHDC2 http://www.ncbi.nlm.nih.gov/gene/23588 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008360 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA KLHL18 http://www.ncbi.nlm.nih.gov/gene/23276 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008361 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA KPNA1 http://www.ncbi.nlm.nih.gov/gene/3836 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008362 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA KTELC1 http://www.ncbi.nlm.nih.gov/gene/56983 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008363 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA LBR http://www.ncbi.nlm.nih.gov/gene/3930 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008364 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA LRRFIP1 http://www.ncbi.nlm.nih.gov/gene/9208 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008365 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA LYN http://www.ncbi.nlm.nih.gov/gene/4067 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008366 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA LYPLA1 http://www.ncbi.nlm.nih.gov/gene/10434 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008367 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA LYSMD1 http://www.ncbi.nlm.nih.gov/gene/388695 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008368 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA LZIC http://www.ncbi.nlm.nih.gov/gene/84328 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008369 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA MAFK http://www.ncbi.nlm.nih.gov/gene/7975 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008370 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA MAP3K7IP3 http://www.ncbi.nlm.nih.gov/gene/257397 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008371 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA MAP7D2 http://www.ncbi.nlm.nih.gov/gene/256714 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008372 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA MBP http://www.ncbi.nlm.nih.gov/gene/4155 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008373 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA MBTPS2 http://www.ncbi.nlm.nih.gov/gene/51360 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008374 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA MDM2 http://www.ncbi.nlm.nih.gov/gene/4193 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008375 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA MECP2 http://www.ncbi.nlm.nih.gov/gene/4204 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008376 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA MKL2 http://www.ncbi.nlm.nih.gov/gene/57496 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008377 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA MKRN1 http://www.ncbi.nlm.nih.gov/gene/23608 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008378 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA MLL http://www.ncbi.nlm.nih.gov/gene/4297 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008379 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA MLLT10 http://www.ncbi.nlm.nih.gov/gene/8028 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008380 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA MMGT1 http://www.ncbi.nlm.nih.gov/gene/93380 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008381 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA MPP6 http://www.ncbi.nlm.nih.gov/gene/51678 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008382 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA MPPE1 http://www.ncbi.nlm.nih.gov/gene/65258 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008383 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA MTPN http://www.ncbi.nlm.nih.gov/gene/767558 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008384 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA MTUS1 http://www.ncbi.nlm.nih.gov/gene/57509 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008385 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA MTX3 http://www.ncbi.nlm.nih.gov/gene/345778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008386 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA NCOA3 http://www.ncbi.nlm.nih.gov/gene/8202 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008387 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA NCOR1 http://www.ncbi.nlm.nih.gov/gene/9611 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008388 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA NDFIP2 http://www.ncbi.nlm.nih.gov/gene/54602 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008389 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA NFAT5 http://www.ncbi.nlm.nih.gov/gene/10725 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008390 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA NFE2L2 http://www.ncbi.nlm.nih.gov/gene/4780 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008391 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA NHLRC2 http://www.ncbi.nlm.nih.gov/gene/374354 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008392 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA NMI http://www.ncbi.nlm.nih.gov/gene/9111 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008393 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA NR3C1 http://www.ncbi.nlm.nih.gov/gene/2908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008394 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA NT5DC1 http://www.ncbi.nlm.nih.gov/gene/221294 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008395 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA NUDT5 http://www.ncbi.nlm.nih.gov/gene/11164 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008396 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA NUP155 http://www.ncbi.nlm.nih.gov/gene/9631 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008397 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA NUP205 http://www.ncbi.nlm.nih.gov/gene/23165 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008398 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA NUP43 http://www.ncbi.nlm.nih.gov/gene/348995 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008399 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA NUP50 http://www.ncbi.nlm.nih.gov/gene/10762 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008400 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA OGT http://www.ncbi.nlm.nih.gov/gene/8473 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008401 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA PABPC4L http://www.ncbi.nlm.nih.gov/gene/132430 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008402 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA PACRGL http://www.ncbi.nlm.nih.gov/gene/133015 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008403 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA PAFAH1B1 http://www.ncbi.nlm.nih.gov/gene/5048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008404 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA PBRM1 http://www.ncbi.nlm.nih.gov/gene/55193 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008405 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA PDE4D http://www.ncbi.nlm.nih.gov/gene/5144 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008406 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA PDE7A http://www.ncbi.nlm.nih.gov/gene/5150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008407 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA PDPK1 http://www.ncbi.nlm.nih.gov/gene/5170 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008408 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA PEX11B http://www.ncbi.nlm.nih.gov/gene/8799 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008409 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA PGRMC2 http://www.ncbi.nlm.nih.gov/gene/10424 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008410 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA PHF3 http://www.ncbi.nlm.nih.gov/gene/23469 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008411 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA PIP5K1C http://www.ncbi.nlm.nih.gov/gene/23396 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008412 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA PLCXD2 http://www.ncbi.nlm.nih.gov/gene/90102 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008413 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA PLCXD3 http://www.ncbi.nlm.nih.gov/gene/345557 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008414 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA PLD1 http://www.ncbi.nlm.nih.gov/gene/5337 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008415 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA PLS3 http://www.ncbi.nlm.nih.gov/gene/5358 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008416 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA PNPO http://www.ncbi.nlm.nih.gov/gene/55163 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008417 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA POLR2H http://www.ncbi.nlm.nih.gov/gene/5437 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008418 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA POLS http://www.ncbi.nlm.nih.gov/gene/11044 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008419 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA POU2F1 http://www.ncbi.nlm.nih.gov/gene/5451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008420 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA PPM1K http://www.ncbi.nlm.nih.gov/gene/152926 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008421 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA PPP2CA http://www.ncbi.nlm.nih.gov/gene/5515 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008422 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA PRDM15 http://www.ncbi.nlm.nih.gov/gene/63977 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008423 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA PTPRJ http://www.ncbi.nlm.nih.gov/gene/5795 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008424 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA PUM2 http://www.ncbi.nlm.nih.gov/gene/23369 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008425 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA RAB8A http://www.ncbi.nlm.nih.gov/gene/4218 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008426 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA RABEP1 http://www.ncbi.nlm.nih.gov/gene/9135 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008427 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA RAD21 http://www.ncbi.nlm.nih.gov/gene/5885 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008428 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA RAD23B http://www.ncbi.nlm.nih.gov/gene/5887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008429 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA RANBP9 http://www.ncbi.nlm.nih.gov/gene/10048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008430 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA RBM22 http://www.ncbi.nlm.nih.gov/gene/55696 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008431 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA RBM39 http://www.ncbi.nlm.nih.gov/gene/643167 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008432 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA RBPSUH http://www.ncbi.nlm.nih.gov/gene/3516 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008433 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA RELL1 http://www.ncbi.nlm.nih.gov/gene/768211 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008434 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA REPIN1 http://www.ncbi.nlm.nih.gov/gene/29803 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008435 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA RFXAP http://www.ncbi.nlm.nih.gov/gene/5994 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008436 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA RIF1 http://www.ncbi.nlm.nih.gov/gene/55183 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008437 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA RORA http://www.ncbi.nlm.nih.gov/gene/6095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008438 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA RPE http://www.ncbi.nlm.nih.gov/gene/729020 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008439 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA RPL7L1 http://www.ncbi.nlm.nih.gov/gene/285855 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008440 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA RYBP http://www.ncbi.nlm.nih.gov/gene/23429 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008441 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA SCARB2 http://www.ncbi.nlm.nih.gov/gene/950 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008442 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA SENP8 http://www.ncbi.nlm.nih.gov/gene/123228 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008443 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA SERP1 http://www.ncbi.nlm.nih.gov/gene/27230 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008444 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA SF3A3 http://www.ncbi.nlm.nih.gov/gene/10946 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008445 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA SFRS11 http://www.ncbi.nlm.nih.gov/gene/9295 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008446 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA SGK3 http://www.ncbi.nlm.nih.gov/gene/23678 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008447 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA SH3BP2 http://www.ncbi.nlm.nih.gov/gene/6452 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008448 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA SLC22A5 http://www.ncbi.nlm.nih.gov/gene/6584 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008449 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA SLTM http://www.ncbi.nlm.nih.gov/gene/79811 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008450 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA SMC3 http://www.ncbi.nlm.nih.gov/gene/9126 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008451 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA SNTB2 http://www.ncbi.nlm.nih.gov/gene/6645 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008452 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA SOCS5 http://www.ncbi.nlm.nih.gov/gene/9655 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008453 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA SOCS6 http://www.ncbi.nlm.nih.gov/gene/9306 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008454 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA SOX13 http://www.ncbi.nlm.nih.gov/gene/9580 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008455 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA SPAG1 http://www.ncbi.nlm.nih.gov/gene/6674 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008456 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA SPAG16 http://www.ncbi.nlm.nih.gov/gene/79582 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008457 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA STARD4 http://www.ncbi.nlm.nih.gov/gene/134429 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008458 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA STK17A http://www.ncbi.nlm.nih.gov/gene/9263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008459 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA STRN http://www.ncbi.nlm.nih.gov/gene/6801 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008460 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA STX12 http://www.ncbi.nlm.nih.gov/gene/23673 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008461 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA SUMO3 http://www.ncbi.nlm.nih.gov/gene/285829 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008462 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA TANC1 http://www.ncbi.nlm.nih.gov/gene/85461 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008463 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA TANC2 http://www.ncbi.nlm.nih.gov/gene/26115 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008464 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA TCF4 http://www.ncbi.nlm.nih.gov/gene/6925 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008465 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA TET3 http://www.ncbi.nlm.nih.gov/gene/200424 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008466 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA TFAP4 http://www.ncbi.nlm.nih.gov/gene/7023 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008467 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA TGIF2 http://www.ncbi.nlm.nih.gov/gene/60436 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008468 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA THAP1 http://www.ncbi.nlm.nih.gov/gene/55145 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008469 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA TMEM181 http://www.ncbi.nlm.nih.gov/gene/57583 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008470 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA TMEM192 http://www.ncbi.nlm.nih.gov/gene/201931 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008471 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA TMEM48 http://www.ncbi.nlm.nih.gov/gene/55706 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008472 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA TNFRSF10B http://www.ncbi.nlm.nih.gov/gene/8795 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008473 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA TPO http://www.ncbi.nlm.nih.gov/gene/7173 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008474 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA TRMT61B http://www.ncbi.nlm.nih.gov/gene/55006 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008475 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA TSHZ1 http://www.ncbi.nlm.nih.gov/gene/10194 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008476 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA TSR1 http://www.ncbi.nlm.nih.gov/gene/55720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008477 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA TTC26 http://www.ncbi.nlm.nih.gov/gene/79989 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008478 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA TUBA1B http://www.ncbi.nlm.nih.gov/gene/10376 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008479 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA TUBA1C http://www.ncbi.nlm.nih.gov/gene/84790 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008480 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA UBA5 http://www.ncbi.nlm.nih.gov/gene/79876 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008481 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA UBE2D1 http://www.ncbi.nlm.nih.gov/gene/7321 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008482 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA UBE2F http://www.ncbi.nlm.nih.gov/gene/140739 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008483 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA UBE2K http://www.ncbi.nlm.nih.gov/gene/3093 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008484 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA UFM1 http://www.ncbi.nlm.nih.gov/gene/51569 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008485 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA UNC119B http://www.ncbi.nlm.nih.gov/gene/84747 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008486 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA USP3 http://www.ncbi.nlm.nih.gov/gene/9960 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008487 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA USP33 http://www.ncbi.nlm.nih.gov/gene/23032 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008488 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA UTP15 http://www.ncbi.nlm.nih.gov/gene/84135 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008489 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA VANGL1 http://www.ncbi.nlm.nih.gov/gene/81839 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008490 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA VEZT http://www.ncbi.nlm.nih.gov/gene/55591 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008491 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA WASL http://www.ncbi.nlm.nih.gov/gene/8976 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008492 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA WBP11 http://www.ncbi.nlm.nih.gov/gene/51729 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008493 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA XPO1 http://www.ncbi.nlm.nih.gov/gene/7514 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008494 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA YIPF5 http://www.ncbi.nlm.nih.gov/gene/81555 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008495 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA YY1 http://www.ncbi.nlm.nih.gov/gene/7528 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008496 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ZBTB39 http://www.ncbi.nlm.nih.gov/gene/9880 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008497 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ZC3H12A http://www.ncbi.nlm.nih.gov/gene/80149 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008498 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ZFP36L2 http://www.ncbi.nlm.nih.gov/gene/678 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008499 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ZFP91 http://www.ncbi.nlm.nih.gov/gene/386607 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008500 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ZFYVE20 http://www.ncbi.nlm.nih.gov/gene/64145 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008501 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ZIC2 http://www.ncbi.nlm.nih.gov/gene/7546 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008502 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ZMYM2 http://www.ncbi.nlm.nih.gov/gene/7750 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008503 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ZNF124 http://www.ncbi.nlm.nih.gov/gene/7678 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008504 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ZNF217 http://www.ncbi.nlm.nih.gov/gene/7764 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008505 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ZNF238 http://www.ncbi.nlm.nih.gov/gene/10472 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008506 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ZNF367 http://www.ncbi.nlm.nih.gov/gene/195828 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008507 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ZNF426 http://www.ncbi.nlm.nih.gov/gene/79088 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008508 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ZNF498 http://www.ncbi.nlm.nih.gov/gene/221785 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008509 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ZNF517 http://www.ncbi.nlm.nih.gov/gene/340385 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008510 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ZNF678 http://www.ncbi.nlm.nih.gov/gene/339500 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008511 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ZNF740 http://www.ncbi.nlm.nih.gov/gene/283337 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008512 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ZNF792 http://www.ncbi.nlm.nih.gov/gene/126375 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008513 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC-3 - Host mRNA ZNF805 http://www.ncbi.nlm.nih.gov/gene/390980 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008514 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC3 - Host mRNA CDKN1A/p21 http://www.ncbi.nlm.nih.gov/gene/1026 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00008515 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC3 - Host mRNA NFKBIA http://www.ncbi.nlm.nih.gov/gene/4792 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00008516 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BC3 - Host mRNA RAD21 http://www.ncbi.nlm.nih.gov/gene/5885 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00008517 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA APOM http://www.ncbi.nlm.nih.gov/gene/55937 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008518 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA ARID1A http://www.ncbi.nlm.nih.gov/gene/8289 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells.Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008519 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA BCL11A http://www.ncbi.nlm.nih.gov/gene/53335 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008520 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA CAST http://www.ncbi.nlm.nih.gov/gene/831 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008521 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008522 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA CDK5R1 http://www.ncbi.nlm.nih.gov/gene/8851 - PAR-CLIP. 22100165 Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008523 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA CNP http://www.ncbi.nlm.nih.gov/gene/1267 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells.Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008524 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA COMMD7 http://www.ncbi.nlm.nih.gov/gene/149951 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells.Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008525 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA COX5B http://www.ncbi.nlm.nih.gov/gene/1329 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008526 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA DCBLD2 http://www.ncbi.nlm.nih.gov/gene/131566 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008527 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA DDX47 http://www.ncbi.nlm.nih.gov/gene/51202 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008528 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA DUSP16 http://www.ncbi.nlm.nih.gov/gene/80824 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells.Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008529 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA E2F7 http://www.ncbi.nlm.nih.gov/gene/144455 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008530 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA EIF2C4 http://www.ncbi.nlm.nih.gov/gene/192670 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells.Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008531 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA EPB41L2 http://www.ncbi.nlm.nih.gov/gene/2037 - PAR-CLIP. 22100165 Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008532 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA EPN2 http://www.ncbi.nlm.nih.gov/gene/22905 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008533 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA GTF2F2 http://www.ncbi.nlm.nih.gov/gene/2963 - PAR-CLIP. 22100165 Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008534 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA GYPE http://www.ncbi.nlm.nih.gov/gene/2996 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008535 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA IL6ST http://www.ncbi.nlm.nih.gov/gene/3572 - PAR-CLIP. 22100165 Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008536 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA KLF12 http://www.ncbi.nlm.nih.gov/gene/11278 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells.Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008537 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA MAFK http://www.ncbi.nlm.nih.gov/gene/7975 - PAR-CLIP. 22100165 Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008538 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA MEF2C http://www.ncbi.nlm.nih.gov/gene/4208 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008539 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA NCOA3 http://www.ncbi.nlm.nih.gov/gene/8202 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells.Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008540 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA NDFIP1 http://www.ncbi.nlm.nih.gov/gene/80762 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008541 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA NFE2L2 http://www.ncbi.nlm.nih.gov/gene/4780 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008542 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA NMI http://www.ncbi.nlm.nih.gov/gene/9111 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells.Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008543 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA NR1D2 http://www.ncbi.nlm.nih.gov/gene/9975 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008544 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA NUP43 http://www.ncbi.nlm.nih.gov/gene/348995 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells.Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008545 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA PDE7A http://www.ncbi.nlm.nih.gov/gene/5150 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells.Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008546 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA PEX11B http://www.ncbi.nlm.nih.gov/gene/8799 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells.Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008547 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA PPP2CA http://www.ncbi.nlm.nih.gov/gene/5515 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells.Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008548 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA PSAT1 http://www.ncbi.nlm.nih.gov/gene/137133 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008549 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA PTPRJ http://www.ncbi.nlm.nih.gov/gene/5795 - PAR-CLIP. 22100165 Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008550 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA RABL5 http://www.ncbi.nlm.nih.gov/gene/64792 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008551 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA RAD21 http://www.ncbi.nlm.nih.gov/gene/5885 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells.Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008552 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA SLC22A5 http://www.ncbi.nlm.nih.gov/gene/6584 - PAR-CLIP. 22100165 Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008553 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA SNN http://www.ncbi.nlm.nih.gov/gene/8303 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008554 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA TCF4 http://www.ncbi.nlm.nih.gov/gene/6925 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells.Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008555 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA TFAP4 http://www.ncbi.nlm.nih.gov/gene/7023 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells.Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008556 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA TRIO http://www.ncbi.nlm.nih.gov/gene/7204 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008557 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA UBL3 http://www.ncbi.nlm.nih.gov/gene/5412 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008558 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA USP33 http://www.ncbi.nlm.nih.gov/gene/23032 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells.Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008559 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA YY1 http://www.ncbi.nlm.nih.gov/gene/7528 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells.Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008560 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA ZHX3 http://www.ncbi.nlm.nih.gov/gene/23051 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008561 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 BJAB/miR-K1 cells - Host mRNA ZNF148 http://www.ncbi.nlm.nih.gov/gene/7707 - PAR-CLIP. 22100165 Table S10A Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K1 cells. VHID00008562 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 - - Host Protein BCL11A http://www.ncbi.nlm.nih.gov/gene/53335 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00008563 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 - - Host Protein CDKN1A(CDKN1A/p21) http://www.ncbi.nlm.nih.gov/gene/1026 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00008564 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 - - Host Protein MAF http://www.ncbi.nlm.nih.gov/gene/4094 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00008565 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 - - Host Protein MAF1 http://www.ncbi.nlm.nih.gov/gene/84232 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00008566 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 - - Host Protein NFKBIA http://www.ncbi.nlm.nih.gov/gene/4792 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00008567 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 - - Host Protein NMI http://www.ncbi.nlm.nih.gov/gene/9111 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00008568 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 - - Host Protein THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00008569 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 - - Host Protein WEE1 http://www.ncbi.nlm.nih.gov/gene/7465 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00008570 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 - - Host mRNA CASP3 http://www.ncbi.nlm.nih.gov/gene/836 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00008571 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 - - Host mRNA CDKN1A http://www.ncbi.nlm.nih.gov/gene/1026 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00008572 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 - - Host mRNA RAD21 http://www.ncbi.nlm.nih.gov/gene/5885 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00008573 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 - - Host mRNA THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VHID00008574 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 293 Cells - Host Protein THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 Downregulation Luciferase de-repression assay. 17500590 We performed luciferase de-repression assays by co-transfection of the THBS1 3'UTR reporter and 2'OMe RNAs specific to individual KSHV miRNAs. Our results demonstrate that THBS1 is targeted by multiple KSHV miRNAs; in particular, miR-K12-1, miR-K12-3-3p, miR-K12-6-3p, and miR-K12-11 lead to strong de-repression of the reporter. VHID00008575 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 DG-75-K10/12 cells - Host Protein CASP3 http://www.ncbi.nlm.nih.gov/gene/836 Downregulation Northern blot analysis, Real-time PCR, Luciferase assays, Small RNA cloning and sequencing, Western blot analysis. 22174674 We found that three KSHV miRNAs, miR-K12-1, 3 and 4-3p, were responsible for the targeting of Casp3.Potential cellular targets that were significantly down-regulated upon KSHV miRNAs expression were identified by microarray profiling. VHID00008576 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 HEK293 cells - Host Protein CASP3 http://www.ncbi.nlm.nih.gov/gene/836 - Luciferase assays,quantitative PCR and western blotting. 22174674 we validated by luciferase reporter assays, quantitative PCR and western blotting caspase 3 (Casp3), a critical factor for the control of apoptosis. Using site-directed mutagenesis, we found that three KSHV miRNAs, miR-K12-1, 3 and 4-3p, were responsible for the targeting of Casp3. . VHID00008577 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 Lymphatic endothelial cells - Host Protein MAF http://www.ncbi.nlm.nih.gov/gene/4094 Downregulation qPCR and qRT-PCR, Western blotting, Luciferase reporter assays. 20080955 Site-directed mutagenesis of KSHV miRNA predicted target sites in the MAF 3'UTR abolished silencing, confirming that miR-K12-1, miR-K12-6-5p, and miR-K12-11 regulate MAF by interacting with the 3'UTR. VHID00008578 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 Lymphocytes - Host Protein CDKN1A(p21) http://www.ncbi.nlm.nih.gov/gene/1026 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 miR-K12-1 inhibition of p21 and NFKB inhibitor IkappaBalpha. VHID00008579 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 Lymphocytes - Host Protein IkappaBalpha(IKBA) http://www.ncbi.nlm.nih.gov/gene/4790 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 miR-K12-1 inhibition of p21 and NFKB inhibitor IkappaBalpha. VHID00008580 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 Lymphocytes - Host Protein MAF http://www.ncbi.nlm.nih.gov/gene/4094 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 miR-K12-1,-6, and -11 decrease of MAF(musculoaponeurotic fibrosarcoma oncogene homolog), K12-4-5p targeting retinoblastoma(Rb)-like protein 2(Rbl2). VHID00008581 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 Lymphocytes - Host Protein NFKB1(NFKB) http://www.ncbi.nlm.nih.gov/gene/4790 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 miR-K12-1 inhibition of p21 and NFKB inhibitor IkappaBalpha. VHID00008582 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(miR-K12-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 Lymphocytes - Host Protein THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 KSHV miR-K12-1, miR-K12-3-3p, miR-K12-6-3p, and miR-K12-11 reduce the expression of THBS1(thrombospondin 1) by interaction with the THBS1 4' UTR. VHID00008583 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(mir-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 - - Host mRNA IkappaBalpha(IKBA) http://www.ncbi.nlm.nih.gov/gene/4792 - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VHID00008584 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(mir-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 - - Host mRNA P21 http://www.ncbi.nlm.nih.gov/gene/644914 - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VHID00008585 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(mir-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 Primary effusion lymphoma (PEL) cell lines - Host Protein CDKN1A http://www.ncbi.nlm.nih.gov/gene/1026 - 3'UTR indicator assays ,RIP-CHIP. 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00008586 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(mir-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 Primary effusion lymphoma (PEL) cell lines - Host Protein NFKBIA http://www.ncbi.nlm.nih.gov/gene/4792 - 3'UTR indicator assays ,RIP-CHIP. 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00008587 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1(mir-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 Primary effusion lymphoma (PEL) cell lines - Host Protein RAD21 http://www.ncbi.nlm.nih.gov/gene/5885 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00008588 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 PEL cells and endothelial cells - Host Protein TGFBR2(TGFbeta-RII) http://www.ncbi.nlm.nih.gov/gene/7048 Downregulation Plasmids and miR mimics, Immunofluorescence assay, Western-blotting, RT-qPCR, Luciferase reporter assay, Apoptosis assay. 22915806 KSHV miR-K10 variants inhibit TGF-beta signaling by targeting TGF-beta type II receptor (TbetaRII). A suppressor of the miRs sensitizes latent KSHV-infected PEL cells to TGF-beta and induces apoptosis. These results indicate that miR-K10 variants manipulate the TGF-beta pathway to confer cells with resistance to the growth-inhibitory effect of TGF-beta. Thus, KSHV miRs might target the tumor-suppressive TGF-beta pathway to promote viral latency and contribute to malignant cellular transformation. VHID00008589 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 - - Host Protein BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00008590 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 - - Host Protein TNFRSF12A http://www.ncbi.nlm.nih.gov/gene/51330 - Bio-Plex assays for IL-8 and MCP-1, Annexin V and TUNEL assays, De novo infections, Luciferase assays, Quantitative RT-PCR assays for cytokine expression, Western blot analysis, Statistical analysis, Caspase activation assay. 20844036 TWEAKR (also known as Fn14, TNFRSF12A, or CD266).Results from luciferase assays with reporter plasmids containing the 3' untranslated region (UTR) of TWEAKR suggest a targeting of TWEAKR by miR-K10a.The expression of TWEAKR was downregulated in cells transfected with miR-K10a as well as during de novo KSHV infection. VHID00008591 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA MARCH2 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008592 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ADPRHL1 http://www.ncbi.nlm.nih.gov/gene/113622 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008593 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA AK3L1 http://www.ncbi.nlm.nih.gov/gene/645619 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008594 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ALG13 http://www.ncbi.nlm.nih.gov/gene/79868 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008595 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA AMD1 http://www.ncbi.nlm.nih.gov/gene/262 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008596 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ANKFY1 http://www.ncbi.nlm.nih.gov/gene/51479 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008597 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ANLN http://www.ncbi.nlm.nih.gov/gene/54443 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008598 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ANP32E http://www.ncbi.nlm.nih.gov/gene/81611 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008599 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA APOLD1 http://www.ncbi.nlm.nih.gov/gene/81575 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008600 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA APPBP2 http://www.ncbi.nlm.nih.gov/gene/10513 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008601 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ARHGAP5 http://www.ncbi.nlm.nih.gov/gene/394 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008602 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ARHGDIB http://www.ncbi.nlm.nih.gov/gene/397 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008603 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ARL8A http://www.ncbi.nlm.nih.gov/gene/127829 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008604 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ASH1L http://www.ncbi.nlm.nih.gov/gene/55870 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008605 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ATF7 http://www.ncbi.nlm.nih.gov/gene/11016 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008606 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ATP2B1 http://www.ncbi.nlm.nih.gov/gene/490 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008607 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ATPBD4 http://www.ncbi.nlm.nih.gov/gene/89978 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008608 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ATXN1 http://www.ncbi.nlm.nih.gov/gene/6310 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008609 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA AVL9 http://www.ncbi.nlm.nih.gov/gene/23080 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008610 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA BAG3 http://www.ncbi.nlm.nih.gov/gene/9531 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008611 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA BRCA1 http://www.ncbi.nlm.nih.gov/gene/672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008612 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA C12orf5 http://www.ncbi.nlm.nih.gov/gene/57103 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008613 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA C12orf73 http://www.ncbi.nlm.nih.gov/gene/728568 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008614 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA C18orf10 http://www.ncbi.nlm.nih.gov/gene/25941 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008615 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA C18orf54 http://www.ncbi.nlm.nih.gov/gene/162681 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008616 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA C1orf9 http://www.ncbi.nlm.nih.gov/gene/51430 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008617 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA C8orf82 http://www.ncbi.nlm.nih.gov/gene/414919 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008618 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA CAB39 http://www.ncbi.nlm.nih.gov/gene/51719 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008619 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA CALCOCO2 http://www.ncbi.nlm.nih.gov/gene/10241 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008620 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA CALM3 http://www.ncbi.nlm.nih.gov/gene/808 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008621 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA CBL http://www.ncbi.nlm.nih.gov/gene/867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008622 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA CCDC88A http://www.ncbi.nlm.nih.gov/gene/55704 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008623 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA CDC7 http://www.ncbi.nlm.nih.gov/gene/8317 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008624 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA CDKN1B http://www.ncbi.nlm.nih.gov/gene/1027 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008625 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA CEP70 http://www.ncbi.nlm.nih.gov/gene/80321 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008626 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA CETN3 http://www.ncbi.nlm.nih.gov/gene/1070 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008627 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA CLEC16A http://www.ncbi.nlm.nih.gov/gene/23274 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008628 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA CLTC http://www.ncbi.nlm.nih.gov/gene/1213 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008629 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA CMTM4 http://www.ncbi.nlm.nih.gov/gene/146223 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008630 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA CREBL2 http://www.ncbi.nlm.nih.gov/gene/1389 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008631 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA CTNNA1 http://www.ncbi.nlm.nih.gov/gene/1495 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008632 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA CTNNB1 http://www.ncbi.nlm.nih.gov/gene/1499 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008633 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA CTNND1 http://www.ncbi.nlm.nih.gov/gene/1500 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008634 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA CUX1 http://www.ncbi.nlm.nih.gov/gene/1523 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008635 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA DAPP1 http://www.ncbi.nlm.nih.gov/gene/27071 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008636 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA DDX6 http://www.ncbi.nlm.nih.gov/gene/1656 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008637 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA DHRS7B http://www.ncbi.nlm.nih.gov/gene/25979 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008638 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA DLG5 http://www.ncbi.nlm.nih.gov/gene/9231 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008639 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA DMTF1 http://www.ncbi.nlm.nih.gov/gene/9988 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008640 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA DNAJB4 http://www.ncbi.nlm.nih.gov/gene/11080 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008641 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA DPP8 http://www.ncbi.nlm.nih.gov/gene/54878 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008642 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA DSTN http://www.ncbi.nlm.nih.gov/gene/11034 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008643 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA DSTYK http://www.ncbi.nlm.nih.gov/gene/25778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008644 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA DVL1 http://www.ncbi.nlm.nih.gov/gene/1855 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008645 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA DYNC1LI2 http://www.ncbi.nlm.nih.gov/gene/1783 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008646 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA E2F7 http://www.ncbi.nlm.nih.gov/gene/144455 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008647 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ECT2 http://www.ncbi.nlm.nih.gov/gene/1894 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008648 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA EEF2 http://www.ncbi.nlm.nih.gov/gene/1938 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008649 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA EIF2S1 http://www.ncbi.nlm.nih.gov/gene/1965 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008650 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA EIF4A1 http://www.ncbi.nlm.nih.gov/gene/728698 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008651 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA EIF5 http://www.ncbi.nlm.nih.gov/gene/1983 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008652 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ERLIN1 http://www.ncbi.nlm.nih.gov/gene/10613 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008653 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA FAM103A1 http://www.ncbi.nlm.nih.gov/gene/83640 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008654 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA FAM171B http://www.ncbi.nlm.nih.gov/gene/165215 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008655 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA FAM63B http://www.ncbi.nlm.nih.gov/gene/54629 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008656 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA FNIP2 http://www.ncbi.nlm.nih.gov/gene/57600 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008657 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA FOXP1 http://www.ncbi.nlm.nih.gov/gene/27086 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008658 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA FOXP2 http://www.ncbi.nlm.nih.gov/gene/93986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008659 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA FRS2 http://www.ncbi.nlm.nih.gov/gene/10818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008660 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA FTSJD1 http://www.ncbi.nlm.nih.gov/gene/55783 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008661 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA GBP3 http://www.ncbi.nlm.nih.gov/gene/2635 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008662 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA GCNT2 http://www.ncbi.nlm.nih.gov/gene/2651 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008663 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA GLRX http://www.ncbi.nlm.nih.gov/gene/2745 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008664 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA GMFB http://www.ncbi.nlm.nih.gov/gene/2764 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008665 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA GMPPB http://www.ncbi.nlm.nih.gov/gene/29925 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008666 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA GPR107 http://www.ncbi.nlm.nih.gov/gene/57720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008667 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA GPRIN3 http://www.ncbi.nlm.nih.gov/gene/285513 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008668 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA GRLF1 http://www.ncbi.nlm.nih.gov/gene/2909 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008669 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA HADHB http://www.ncbi.nlm.nih.gov/gene/3032 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008670 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA HBP1 http://www.ncbi.nlm.nih.gov/gene/26959 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008671 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA HDLBP http://www.ncbi.nlm.nih.gov/gene/3069 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008672 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA HELLS http://www.ncbi.nlm.nih.gov/gene/3070 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008673 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA HGF http://www.ncbi.nlm.nih.gov/gene/3082 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008674 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA HIAT1 http://www.ncbi.nlm.nih.gov/gene/64645 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008675 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA HNRNPK http://www.ncbi.nlm.nih.gov/gene/3190 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008676 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA HOXB7 http://www.ncbi.nlm.nih.gov/gene/3217 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008677 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA HSBP1 http://www.ncbi.nlm.nih.gov/gene/3281 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008678 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA HSPA1B http://www.ncbi.nlm.nih.gov/gene/3303 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008679 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA IFNGR2 http://www.ncbi.nlm.nih.gov/gene/3460 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008680 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA IFT140 http://www.ncbi.nlm.nih.gov/gene/9742 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008681 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA IGDCC4 http://www.ncbi.nlm.nih.gov/gene/57722 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008682 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA IGF2BP3 http://www.ncbi.nlm.nih.gov/gene/10643 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008683 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA INO80D http://www.ncbi.nlm.nih.gov/gene/54891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008684 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA IPO9 http://www.ncbi.nlm.nih.gov/gene/55705 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008685 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA IQGAP3 http://www.ncbi.nlm.nih.gov/gene/128239 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008686 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ITSN1 http://www.ncbi.nlm.nih.gov/gene/6453 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008687 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA KBTBD2 http://www.ncbi.nlm.nih.gov/gene/25948 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008688 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA KBTBD6 http://www.ncbi.nlm.nih.gov/gene/89890 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008689 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA KCTD9 http://www.ncbi.nlm.nih.gov/gene/642513 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008690 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA KDM3B http://www.ncbi.nlm.nih.gov/gene/51780 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008691 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA KDM5B http://www.ncbi.nlm.nih.gov/gene/10765 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008692 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA KIAA0562 http://www.ncbi.nlm.nih.gov/gene/9731 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008693 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA KLHDC10 http://www.ncbi.nlm.nih.gov/gene/23008 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008694 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA KLHL8 http://www.ncbi.nlm.nih.gov/gene/57563 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008695 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA LAMP2 http://www.ncbi.nlm.nih.gov/gene/3920 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008696 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA LANCL1 http://www.ncbi.nlm.nih.gov/gene/10314 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008697 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA LAPTM4A http://www.ncbi.nlm.nih.gov/gene/9741 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008698 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA LCOR http://www.ncbi.nlm.nih.gov/gene/84458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008699 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA LIX1L http://www.ncbi.nlm.nih.gov/gene/128077 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008700 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA LMNB2 http://www.ncbi.nlm.nih.gov/gene/84823 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008701 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA LPGAT1 http://www.ncbi.nlm.nih.gov/gene/9926 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008702 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA LRRC8B http://www.ncbi.nlm.nih.gov/gene/23507 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008703 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA MAML1 http://www.ncbi.nlm.nih.gov/gene/9794 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008704 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA MBTD1 http://www.ncbi.nlm.nih.gov/gene/54799 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008705 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA MBTPS2 http://www.ncbi.nlm.nih.gov/gene/51360 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008706 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA MEX3C http://www.ncbi.nlm.nih.gov/gene/51320 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008707 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA MMADHC http://www.ncbi.nlm.nih.gov/gene/27249 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008708 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA MRPL42 http://www.ncbi.nlm.nih.gov/gene/28977 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008709 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA MTFR1 http://www.ncbi.nlm.nih.gov/gene/9650 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008710 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA MTPN http://www.ncbi.nlm.nih.gov/gene/767558 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008711 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA MTX3 http://www.ncbi.nlm.nih.gov/gene/345778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008712 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA N4BP2L1 http://www.ncbi.nlm.nih.gov/gene/90634 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008713 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA NDUFC1 http://www.ncbi.nlm.nih.gov/gene/4717 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008714 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA NFIA http://www.ncbi.nlm.nih.gov/gene/4774 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008715 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA NGRN http://www.ncbi.nlm.nih.gov/gene/51335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008716 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA NHLRC2 http://www.ncbi.nlm.nih.gov/gene/374354 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008717 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA NOTCH2NL http://www.ncbi.nlm.nih.gov/gene/388677 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008718 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA NSD1 http://www.ncbi.nlm.nih.gov/gene/64324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008719 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA NUFIP2 http://www.ncbi.nlm.nih.gov/gene/57532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008720 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA OTUD4 http://www.ncbi.nlm.nih.gov/gene/54726 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008721 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA PEX13 http://www.ncbi.nlm.nih.gov/gene/5194 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008722 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA PGM3 http://www.ncbi.nlm.nih.gov/gene/5238 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008723 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA PGRMC1 http://www.ncbi.nlm.nih.gov/gene/10857 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008724 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA PHC3 http://www.ncbi.nlm.nih.gov/gene/80012 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008725 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA PHF17 http://www.ncbi.nlm.nih.gov/gene/79960 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008726 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA PIK3C2A http://www.ncbi.nlm.nih.gov/gene/5286 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008727 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA PIK3C2B http://www.ncbi.nlm.nih.gov/gene/5287 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008728 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA PIK3R3 http://www.ncbi.nlm.nih.gov/gene/8503 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008729 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA PKN2 http://www.ncbi.nlm.nih.gov/gene/5586 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008730 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA PMPCB http://www.ncbi.nlm.nih.gov/gene/9512 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008731 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA POLI http://www.ncbi.nlm.nih.gov/gene/11201 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008732 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA POMP http://www.ncbi.nlm.nih.gov/gene/51371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008733 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA POU2F1 http://www.ncbi.nlm.nih.gov/gene/5451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008734 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA PPIB http://www.ncbi.nlm.nih.gov/gene/5479 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008735 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA PPM1G http://www.ncbi.nlm.nih.gov/gene/5496 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008736 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA PPP1R9A http://www.ncbi.nlm.nih.gov/gene/55607 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008737 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA PRKAB2 http://www.ncbi.nlm.nih.gov/gene/5565 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008738 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA PRKDC http://www.ncbi.nlm.nih.gov/gene/5591 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008739 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA PROK2 http://www.ncbi.nlm.nih.gov/gene/60675 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008740 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA PRPF40A http://www.ncbi.nlm.nih.gov/gene/55660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008741 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA PTPLAD1 http://www.ncbi.nlm.nih.gov/gene/51495 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008742 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA PTPN13 http://www.ncbi.nlm.nih.gov/gene/5783 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008743 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA PXMP4 http://www.ncbi.nlm.nih.gov/gene/11264 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008744 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA PYROXD1 http://www.ncbi.nlm.nih.gov/gene/79912 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008745 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA RAB11FIP1 http://www.ncbi.nlm.nih.gov/gene/80223 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008746 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA RABGAP1L http://www.ncbi.nlm.nih.gov/gene/9910 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008747 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA RABL3 http://www.ncbi.nlm.nih.gov/gene/285282 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008748 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA RALGPS2 http://www.ncbi.nlm.nih.gov/gene/55103 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008749 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA RAPH1 http://www.ncbi.nlm.nih.gov/gene/65059 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008750 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA RBBP7 http://www.ncbi.nlm.nih.gov/gene/5931 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008751 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA RCHY1 http://www.ncbi.nlm.nih.gov/gene/25898 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008752 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA RDX http://www.ncbi.nlm.nih.gov/gene/5962 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008753 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA REV1 http://www.ncbi.nlm.nih.gov/gene/51455 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008754 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA RGL2 http://www.ncbi.nlm.nih.gov/gene/5863 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008755 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA RNF111 http://www.ncbi.nlm.nih.gov/gene/54778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008756 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA RPS6KA3 http://www.ncbi.nlm.nih.gov/gene/6197 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008757 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA RSF1 http://www.ncbi.nlm.nih.gov/gene/51773 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008758 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA RUFY2 http://www.ncbi.nlm.nih.gov/gene/55680 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008759 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA SBDS http://www.ncbi.nlm.nih.gov/gene/155370 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008760 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA SEC62 http://www.ncbi.nlm.nih.gov/gene/7095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008761 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA SELT http://www.ncbi.nlm.nih.gov/gene/51714 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008762 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA SETD5 http://www.ncbi.nlm.nih.gov/gene/55209 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008763 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA SETD6 http://www.ncbi.nlm.nih.gov/gene/79918 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008764 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA SH3GL1 http://www.ncbi.nlm.nih.gov/gene/6455 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008765 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA SIAH1 http://www.ncbi.nlm.nih.gov/gene/6477 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008766 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA SIKE1 http://www.ncbi.nlm.nih.gov/gene/80143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008767 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA SLC11A2 http://www.ncbi.nlm.nih.gov/gene/4891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008768 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA SLC23A2 http://www.ncbi.nlm.nih.gov/gene/9962 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008769 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA SLC30A7 http://www.ncbi.nlm.nih.gov/gene/148867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008770 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA SLC41A1 http://www.ncbi.nlm.nih.gov/gene/254428 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008771 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA SMAD4 http://www.ncbi.nlm.nih.gov/gene/4089 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008772 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA SNORD1C http://www.ncbi.nlm.nih.gov/gene/677850 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008773 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA SNX13 http://www.ncbi.nlm.nih.gov/gene/23161 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008774 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA SOCS5 http://www.ncbi.nlm.nih.gov/gene/9655 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008775 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA SOS1 http://www.ncbi.nlm.nih.gov/gene/6654 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008776 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA SP100 http://www.ncbi.nlm.nih.gov/gene/6672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008777 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA SPAG9 http://www.ncbi.nlm.nih.gov/gene/9043 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008778 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA TAOK1 http://www.ncbi.nlm.nih.gov/gene/57551 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008779 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA TBC1D5 http://www.ncbi.nlm.nih.gov/gene/9779 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008780 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA TCF7L2 http://www.ncbi.nlm.nih.gov/gene/6934 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008781 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA TGIF2 http://www.ncbi.nlm.nih.gov/gene/60436 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008782 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA TMEM181 http://www.ncbi.nlm.nih.gov/gene/57583 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008783 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA TMEM192 http://www.ncbi.nlm.nih.gov/gene/201931 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008784 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA TMTC3 http://www.ncbi.nlm.nih.gov/gene/160418 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008785 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA TMX3 http://www.ncbi.nlm.nih.gov/gene/54495 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008786 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA TNRC6B http://www.ncbi.nlm.nih.gov/gene/23112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008787 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA TP53INP2 http://www.ncbi.nlm.nih.gov/gene/58476 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008788 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA TP53RK http://www.ncbi.nlm.nih.gov/gene/112858 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008789 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA TRPS1 http://www.ncbi.nlm.nih.gov/gene/7227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008790 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA TRUB1 http://www.ncbi.nlm.nih.gov/gene/142940 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008791 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA TSC22D2 http://www.ncbi.nlm.nih.gov/gene/9819 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008792 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA TXLNB http://www.ncbi.nlm.nih.gov/gene/167838 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008793 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA UBA6 http://www.ncbi.nlm.nih.gov/gene/55236 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008794 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA UBE2CBP http://www.ncbi.nlm.nih.gov/gene/90025 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008795 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA UBN2 http://www.ncbi.nlm.nih.gov/gene/254048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008796 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA UBP1 http://www.ncbi.nlm.nih.gov/gene/7342 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008797 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA UBXN2B http://www.ncbi.nlm.nih.gov/gene/137886 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008798 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA UBXN4 http://www.ncbi.nlm.nih.gov/gene/23190 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008799 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA USP31 http://www.ncbi.nlm.nih.gov/gene/57478 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008800 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA USP42 http://www.ncbi.nlm.nih.gov/gene/84132 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008801 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA USP8 http://www.ncbi.nlm.nih.gov/gene/9101 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008802 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA VDAC1 http://www.ncbi.nlm.nih.gov/gene/7416 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008803 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA VPS26A http://www.ncbi.nlm.nih.gov/gene/9559 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008804 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA VPS52 http://www.ncbi.nlm.nih.gov/gene/6293 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008805 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA WDR75 http://www.ncbi.nlm.nih.gov/gene/84128 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008806 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA WDR82 http://www.ncbi.nlm.nih.gov/gene/80335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008807 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA WHSC1 http://www.ncbi.nlm.nih.gov/gene/7468 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008808 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA WIPF2 http://www.ncbi.nlm.nih.gov/gene/147179 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008809 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA XPO4 http://www.ncbi.nlm.nih.gov/gene/64328 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008810 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA YWHAG http://www.ncbi.nlm.nih.gov/gene/7532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008811 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ZBTB42 http://www.ncbi.nlm.nih.gov/gene/100128927 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008812 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ZBTB43 http://www.ncbi.nlm.nih.gov/gene/23099 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008813 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ZCCHC3 http://www.ncbi.nlm.nih.gov/gene/85364 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008814 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ZDHHC17 http://www.ncbi.nlm.nih.gov/gene/23390 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008815 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ZHX1 http://www.ncbi.nlm.nih.gov/gene/11244 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008816 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ZNF138 http://www.ncbi.nlm.nih.gov/gene/7697 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008817 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ZNF292 http://www.ncbi.nlm.nih.gov/gene/23036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008818 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ZNF451 http://www.ncbi.nlm.nih.gov/gene/26036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008819 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ZNF618 http://www.ncbi.nlm.nih.gov/gene/114991 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008820 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ZNF652 http://www.ncbi.nlm.nih.gov/gene/22834 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008821 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-1 - Host mRNA ZNF776 http://www.ncbi.nlm.nih.gov/gene/284309 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008822 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA MARCH2 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008823 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ACSS1 http://www.ncbi.nlm.nih.gov/gene/84532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008824 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ADPRHL1 http://www.ncbi.nlm.nih.gov/gene/113622 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008825 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA AK3L1 http://www.ncbi.nlm.nih.gov/gene/645619 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008826 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ALG13 http://www.ncbi.nlm.nih.gov/gene/79868 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008827 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ANLN http://www.ncbi.nlm.nih.gov/gene/54443 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008828 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ANXA11 http://www.ncbi.nlm.nih.gov/gene/311 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008829 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA AP3M1 http://www.ncbi.nlm.nih.gov/gene/26985 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008830 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA APPBP2 http://www.ncbi.nlm.nih.gov/gene/10513 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008831 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ARL8A http://www.ncbi.nlm.nih.gov/gene/127829 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008832 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ASH1L http://www.ncbi.nlm.nih.gov/gene/55870 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008833 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ATF7 http://www.ncbi.nlm.nih.gov/gene/11016 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008834 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ATP2B1 http://www.ncbi.nlm.nih.gov/gene/490 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008835 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ATPBD4 http://www.ncbi.nlm.nih.gov/gene/89978 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008836 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ATRN http://www.ncbi.nlm.nih.gov/gene/8455 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008837 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA AVL9 http://www.ncbi.nlm.nih.gov/gene/23080 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008838 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA BAG3 http://www.ncbi.nlm.nih.gov/gene/9531 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008839 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA BRPF3 http://www.ncbi.nlm.nih.gov/gene/27154 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008840 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA C17orf45 http://www.ncbi.nlm.nih.gov/gene/125144 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008841 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA C18orf10 http://www.ncbi.nlm.nih.gov/gene/25941 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008842 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA C18orf54 http://www.ncbi.nlm.nih.gov/gene/162681 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008843 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA C19orf2 http://www.ncbi.nlm.nih.gov/gene/8725 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008844 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA C9orf40 http://www.ncbi.nlm.nih.gov/gene/55071 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008845 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA CAB39 http://www.ncbi.nlm.nih.gov/gene/51719 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008846 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA CALM3 http://www.ncbi.nlm.nih.gov/gene/808 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008847 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA CBL http://www.ncbi.nlm.nih.gov/gene/867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008848 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA CCDC34 http://www.ncbi.nlm.nih.gov/gene/91057 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008849 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA CCDC88A http://www.ncbi.nlm.nih.gov/gene/55704 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008850 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA CDC7 http://www.ncbi.nlm.nih.gov/gene/8317 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008851 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA CDKN1B http://www.ncbi.nlm.nih.gov/gene/1027 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008852 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA CETN3 http://www.ncbi.nlm.nih.gov/gene/1070 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008853 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA CLEC16A http://www.ncbi.nlm.nih.gov/gene/23274 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008854 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA CMTM4 http://www.ncbi.nlm.nih.gov/gene/146223 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008855 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA CREBL2 http://www.ncbi.nlm.nih.gov/gene/1389 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008856 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA CROT http://www.ncbi.nlm.nih.gov/gene/54677 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008857 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA CTNNB1 http://www.ncbi.nlm.nih.gov/gene/1499 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008858 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA CTNND1 http://www.ncbi.nlm.nih.gov/gene/1500 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008859 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA CUX1 http://www.ncbi.nlm.nih.gov/gene/1523 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008860 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA DAPP1 http://www.ncbi.nlm.nih.gov/gene/27071 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008861 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA DDX56 http://www.ncbi.nlm.nih.gov/gene/54606 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008862 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA DHRS7B http://www.ncbi.nlm.nih.gov/gene/25979 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008863 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA DLG5 http://www.ncbi.nlm.nih.gov/gene/9231 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008864 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA DMTF1 http://www.ncbi.nlm.nih.gov/gene/9988 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008865 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA DNAJB4 http://www.ncbi.nlm.nih.gov/gene/11080 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008866 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA DSTN http://www.ncbi.nlm.nih.gov/gene/11034 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008867 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA DSTYK http://www.ncbi.nlm.nih.gov/gene/25778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008868 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA DVL1 http://www.ncbi.nlm.nih.gov/gene/1855 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008869 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA DYNC1LI2 http://www.ncbi.nlm.nih.gov/gene/1783 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008870 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA DYNLT3 http://www.ncbi.nlm.nih.gov/gene/6990 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008871 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA E2F7 http://www.ncbi.nlm.nih.gov/gene/144455 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008872 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ECT2 http://www.ncbi.nlm.nih.gov/gene/1894 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008873 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA EEF2 http://www.ncbi.nlm.nih.gov/gene/1938 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008874 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA EIF4A1 http://www.ncbi.nlm.nih.gov/gene/728698 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008875 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA EIF5 http://www.ncbi.nlm.nih.gov/gene/1983 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008876 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ERLIN1 http://www.ncbi.nlm.nih.gov/gene/10613 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008877 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA FADS1 http://www.ncbi.nlm.nih.gov/gene/3992 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008878 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA FAM103A1 http://www.ncbi.nlm.nih.gov/gene/83640 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008879 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA FAM63B http://www.ncbi.nlm.nih.gov/gene/54629 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008880 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA FOXO1 http://www.ncbi.nlm.nih.gov/gene/2308 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008881 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA FOXP2 http://www.ncbi.nlm.nih.gov/gene/93986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008882 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA FRS2 http://www.ncbi.nlm.nih.gov/gene/10818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008883 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA FUT4 http://www.ncbi.nlm.nih.gov/gene/2526 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008884 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA GCNT2 http://www.ncbi.nlm.nih.gov/gene/2651 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008885 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA GLRX http://www.ncbi.nlm.nih.gov/gene/2745 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008886 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA GMFB http://www.ncbi.nlm.nih.gov/gene/2764 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008887 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA GMPPB http://www.ncbi.nlm.nih.gov/gene/29925 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008888 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA GPR107 http://www.ncbi.nlm.nih.gov/gene/57720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008889 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA GPRIN3 http://www.ncbi.nlm.nih.gov/gene/285513 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008890 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA HBP1 http://www.ncbi.nlm.nih.gov/gene/26959 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008891 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA HDLBP http://www.ncbi.nlm.nih.gov/gene/3069 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008892 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA HELLS http://www.ncbi.nlm.nih.gov/gene/3070 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008893 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA HSBP1 http://www.ncbi.nlm.nih.gov/gene/3281 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008894 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA IFIH1 http://www.ncbi.nlm.nih.gov/gene/64135 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008895 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA IFNGR2 http://www.ncbi.nlm.nih.gov/gene/3460 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008896 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA IGF1R http://www.ncbi.nlm.nih.gov/gene/3480 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008897 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA IGF2BP3 http://www.ncbi.nlm.nih.gov/gene/10643 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008898 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA INO80D http://www.ncbi.nlm.nih.gov/gene/54891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008899 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA IPO9 http://www.ncbi.nlm.nih.gov/gene/55705 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008900 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA IQGAP3 http://www.ncbi.nlm.nih.gov/gene/128239 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008901 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA IRAK4 http://www.ncbi.nlm.nih.gov/gene/51135 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008902 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ITSN1 http://www.ncbi.nlm.nih.gov/gene/6453 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008903 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA KBTBD2 http://www.ncbi.nlm.nih.gov/gene/25948 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008904 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA KCTD9 http://www.ncbi.nlm.nih.gov/gene/642513 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008905 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA KDM3B http://www.ncbi.nlm.nih.gov/gene/51780 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008906 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA KDM5B http://www.ncbi.nlm.nih.gov/gene/10765 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008907 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA KIAA0562 http://www.ncbi.nlm.nih.gov/gene/9731 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008908 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA KLHDC10 http://www.ncbi.nlm.nih.gov/gene/23008 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008909 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA KLHL8 http://www.ncbi.nlm.nih.gov/gene/57563 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008910 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA LAMP2 http://www.ncbi.nlm.nih.gov/gene/3920 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008911 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA LANCL1 http://www.ncbi.nlm.nih.gov/gene/10314 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008912 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA LAPTM4A http://www.ncbi.nlm.nih.gov/gene/9741 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008913 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA LATS1 http://www.ncbi.nlm.nih.gov/gene/9113 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008914 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA LCOR http://www.ncbi.nlm.nih.gov/gene/84458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008915 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA LIX1L http://www.ncbi.nlm.nih.gov/gene/128077 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008916 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA LMNB2 http://www.ncbi.nlm.nih.gov/gene/84823 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008917 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA LRRC8B http://www.ncbi.nlm.nih.gov/gene/23507 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008918 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA MMADHC http://www.ncbi.nlm.nih.gov/gene/27249 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008919 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA MRPL42 http://www.ncbi.nlm.nih.gov/gene/28977 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008920 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA MT1E http://www.ncbi.nlm.nih.gov/gene/4500 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008921 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA MTFR1 http://www.ncbi.nlm.nih.gov/gene/9650 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008922 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA MTPN http://www.ncbi.nlm.nih.gov/gene/767558 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008923 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA MTX3 http://www.ncbi.nlm.nih.gov/gene/345778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008924 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA MYO10 http://www.ncbi.nlm.nih.gov/gene/4651 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008925 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA NAT13 http://www.ncbi.nlm.nih.gov/gene/80218 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008926 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA NDUFC1 http://www.ncbi.nlm.nih.gov/gene/4717 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008927 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA NGRN http://www.ncbi.nlm.nih.gov/gene/51335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008928 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA NHLRC2 http://www.ncbi.nlm.nih.gov/gene/374354 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008929 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA NSD1 http://www.ncbi.nlm.nih.gov/gene/64324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008930 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA NSF http://www.ncbi.nlm.nih.gov/gene/4905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008931 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA NUDT15 http://www.ncbi.nlm.nih.gov/gene/55270 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008932 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA NUFIP2 http://www.ncbi.nlm.nih.gov/gene/57532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008933 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA PEX13 http://www.ncbi.nlm.nih.gov/gene/5194 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008934 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA PGM3 http://www.ncbi.nlm.nih.gov/gene/5238 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008935 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA PGRMC1 http://www.ncbi.nlm.nih.gov/gene/10857 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008936 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA PHACTR4 http://www.ncbi.nlm.nih.gov/gene/65979 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008937 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA PKN2 http://www.ncbi.nlm.nih.gov/gene/5586 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008938 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA PMPCB http://www.ncbi.nlm.nih.gov/gene/9512 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008939 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA PNLDC1 http://www.ncbi.nlm.nih.gov/gene/154197 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008940 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA POLI http://www.ncbi.nlm.nih.gov/gene/11201 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008941 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA POLR3E http://www.ncbi.nlm.nih.gov/gene/55718 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008942 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA POLR3K http://www.ncbi.nlm.nih.gov/gene/51728 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008943 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA POMP http://www.ncbi.nlm.nih.gov/gene/51371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008944 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA POU2F1 http://www.ncbi.nlm.nih.gov/gene/5451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008945 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA PPIF http://www.ncbi.nlm.nih.gov/gene/10105 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008946 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA PPM1G http://www.ncbi.nlm.nih.gov/gene/5496 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008947 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA PRKAB2 http://www.ncbi.nlm.nih.gov/gene/5565 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008948 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA PRKDC http://www.ncbi.nlm.nih.gov/gene/5591 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008949 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA PROK2 http://www.ncbi.nlm.nih.gov/gene/60675 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008950 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA PRPF40A http://www.ncbi.nlm.nih.gov/gene/55660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008951 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA PTPN1 http://www.ncbi.nlm.nih.gov/gene/5770 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008952 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA PTPN13 http://www.ncbi.nlm.nih.gov/gene/5783 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008953 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA PTPN2 http://www.ncbi.nlm.nih.gov/gene/5771 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008954 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA PXMP4 http://www.ncbi.nlm.nih.gov/gene/11264 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008955 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA PYROXD1 http://www.ncbi.nlm.nih.gov/gene/79912 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008956 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA RAB11FIP1 http://www.ncbi.nlm.nih.gov/gene/80223 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008957 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA RABL3 http://www.ncbi.nlm.nih.gov/gene/285282 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008958 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA RAPH1 http://www.ncbi.nlm.nih.gov/gene/65059 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008959 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA RBBP7 http://www.ncbi.nlm.nih.gov/gene/5931 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008960 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA RBCK1 http://www.ncbi.nlm.nih.gov/gene/10616 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008961 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA RCHY1 http://www.ncbi.nlm.nih.gov/gene/25898 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008962 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA RDX http://www.ncbi.nlm.nih.gov/gene/5962 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008963 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA RGL2 http://www.ncbi.nlm.nih.gov/gene/5863 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008964 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA RPS6KA3 http://www.ncbi.nlm.nih.gov/gene/6197 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008965 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA RSF1 http://www.ncbi.nlm.nih.gov/gene/51773 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008966 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA RUFY2 http://www.ncbi.nlm.nih.gov/gene/55680 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008967 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SBDS http://www.ncbi.nlm.nih.gov/gene/155370 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008968 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SEC62 http://www.ncbi.nlm.nih.gov/gene/7095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008969 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SELT http://www.ncbi.nlm.nih.gov/gene/51714 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008970 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SERPINB9 http://www.ncbi.nlm.nih.gov/gene/5272 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008971 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SETD5 http://www.ncbi.nlm.nih.gov/gene/55209 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008972 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SFMBT1 http://www.ncbi.nlm.nih.gov/gene/51460 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008973 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SH3GL1 http://www.ncbi.nlm.nih.gov/gene/6455 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008974 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SIAH1 http://www.ncbi.nlm.nih.gov/gene/6477 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008975 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SIKE1 http://www.ncbi.nlm.nih.gov/gene/80143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008976 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SIRT1 http://www.ncbi.nlm.nih.gov/gene/23411 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008977 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SLC11A2 http://www.ncbi.nlm.nih.gov/gene/4891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008978 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SLC12A6 http://www.ncbi.nlm.nih.gov/gene/9990 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008979 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SLC23A2 http://www.ncbi.nlm.nih.gov/gene/9962 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008980 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SLC25A13 http://www.ncbi.nlm.nih.gov/gene/10165 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008981 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SLC30A7 http://www.ncbi.nlm.nih.gov/gene/148867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008982 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SLC36A1 http://www.ncbi.nlm.nih.gov/gene/206358 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008983 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SLC38A2 http://www.ncbi.nlm.nih.gov/gene/54407 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008984 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SMAD4 http://www.ncbi.nlm.nih.gov/gene/4089 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008985 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SOCS6 http://www.ncbi.nlm.nih.gov/gene/9306 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008986 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SOS1 http://www.ncbi.nlm.nih.gov/gene/6654 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008987 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SP100 http://www.ncbi.nlm.nih.gov/gene/6672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008988 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SPAG9 http://www.ncbi.nlm.nih.gov/gene/9043 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008989 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA SPC24 http://www.ncbi.nlm.nih.gov/gene/147841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008990 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA TAOK1 http://www.ncbi.nlm.nih.gov/gene/57551 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008991 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA TGIF2 http://www.ncbi.nlm.nih.gov/gene/60436 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008992 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA TMEM181 http://www.ncbi.nlm.nih.gov/gene/57583 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008993 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA TMEM192 http://www.ncbi.nlm.nih.gov/gene/201931 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008994 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA TMTC3 http://www.ncbi.nlm.nih.gov/gene/160418 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008995 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA TMX3 http://www.ncbi.nlm.nih.gov/gene/54495 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008996 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA TP53INP2 http://www.ncbi.nlm.nih.gov/gene/58476 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008997 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA TRAM2 http://www.ncbi.nlm.nih.gov/gene/9697 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008998 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA TRPS1 http://www.ncbi.nlm.nih.gov/gene/7227 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00008999 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA TSC22D2 http://www.ncbi.nlm.nih.gov/gene/9819 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009000 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA TXLNB http://www.ncbi.nlm.nih.gov/gene/167838 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009001 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA UBN2 http://www.ncbi.nlm.nih.gov/gene/254048 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009002 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA UBP1 http://www.ncbi.nlm.nih.gov/gene/7342 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009003 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA UBXN2B http://www.ncbi.nlm.nih.gov/gene/137886 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009004 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA UHRF1BP1 http://www.ncbi.nlm.nih.gov/gene/54887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009005 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA USP31 http://www.ncbi.nlm.nih.gov/gene/57478 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009006 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA USP8 http://www.ncbi.nlm.nih.gov/gene/9101 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009007 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA VDAC1 http://www.ncbi.nlm.nih.gov/gene/7416 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009008 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA VPS26A http://www.ncbi.nlm.nih.gov/gene/9559 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009009 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA VPS52 http://www.ncbi.nlm.nih.gov/gene/6293 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009010 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA WDR75 http://www.ncbi.nlm.nih.gov/gene/84128 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009011 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA WHSC1 http://www.ncbi.nlm.nih.gov/gene/7468 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009012 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA WIPF2 http://www.ncbi.nlm.nih.gov/gene/147179 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009013 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA XPO4 http://www.ncbi.nlm.nih.gov/gene/64328 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009014 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA XRN1 http://www.ncbi.nlm.nih.gov/gene/54464 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009015 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA YWHAG http://www.ncbi.nlm.nih.gov/gene/7532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009016 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ZBTB43 http://www.ncbi.nlm.nih.gov/gene/23099 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009017 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ZCCHC14 http://www.ncbi.nlm.nih.gov/gene/23174 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009018 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ZCCHC3 http://www.ncbi.nlm.nih.gov/gene/85364 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009019 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ZDHHC17 http://www.ncbi.nlm.nih.gov/gene/23390 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009020 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ZHX1 http://www.ncbi.nlm.nih.gov/gene/11244 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009021 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ZNF292 http://www.ncbi.nlm.nih.gov/gene/23036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009022 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ZNF367 http://www.ncbi.nlm.nih.gov/gene/195828 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009023 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ZNF451 http://www.ncbi.nlm.nih.gov/gene/26036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009024 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 BC-3 - Host mRNA ZNFX1 http://www.ncbi.nlm.nih.gov/gene/57169 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009025 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 Primary effusion lymphoma (PEL) cell lines - Host Protein TNFRSF12A http://www.ncbi.nlm.nih.gov/gene/51330 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00009026 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K12-10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 - - Host Protein CDKN1B http://www.ncbi.nlm.nih.gov/gene/1027 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00009027 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K12-10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 - - Host Protein CTNND1 http://www.ncbi.nlm.nih.gov/gene/1500 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00009028 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K12-10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 - - Host Protein MTUS1 http://www.ncbi.nlm.nih.gov/gene/57509 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00009029 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K12-10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 - - Host Protein PKN2 http://www.ncbi.nlm.nih.gov/gene/5586 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00009030 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K12-10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 - - Host Protein SOS1 http://www.ncbi.nlm.nih.gov/gene/6654 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00009031 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K12-10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 - - Host Protein TPD52 http://www.ncbi.nlm.nih.gov/gene/7163 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00009032 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K12-10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 - - Host Protein ZFYVE9 http://www.ncbi.nlm.nih.gov/gene/9372 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00009033 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K12-10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 - - Host Protein BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00009034 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K12-10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 - - Host Protein TNFRSF12A(TNFRSF12A/TWEAKR) http://www.ncbi.nlm.nih.gov/gene/51330 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00009035 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K12-10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 - - Host Protein TWEAKR http://www.ncbi.nlm.nih.gov/gene/51330 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00009036 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K12-10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 - - Host mRNA TNFRSF12A http://www.ncbi.nlm.nih.gov/gene/51330 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009037 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10a(miR-K12-10a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002472 Lymphocytes - Host Protein TWEAKR http://www.ncbi.nlm.nih.gov/gene/51330 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 miR-K12-10a reduction of TWEAKR,miR-K12-1, -6, and -11 decrease of MAF(musculoaponeurotic fibrosarcoma oncogene homolog)K12-4-5p targeting retinoblastoma(Rb)-like protein 2(Rbl2) and miR-K12-5 and -9* suppressing ORF50 mRNAc. VHID00009038 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA SEPT2 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009039 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA ANKIB1 http://www.ncbi.nlm.nih.gov/gene/54467 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009040 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA ARID1A http://www.ncbi.nlm.nih.gov/gene/8289 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009041 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA ATF2 http://www.ncbi.nlm.nih.gov/gene/1386 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009042 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA AZIN1 http://www.ncbi.nlm.nih.gov/gene/51582 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009043 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA BAZ2A http://www.ncbi.nlm.nih.gov/gene/11176 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009044 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA C13orf23 http://www.ncbi.nlm.nih.gov/gene/80209 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009045 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA C17orf42 http://www.ncbi.nlm.nih.gov/gene/79736 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009046 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA CCNL1 http://www.ncbi.nlm.nih.gov/gene/57018 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009047 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA CLDN12 http://www.ncbi.nlm.nih.gov/gene/9069 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009048 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA COMMD2 http://www.ncbi.nlm.nih.gov/gene/51122 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009049 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA CTSO http://www.ncbi.nlm.nih.gov/gene/1519 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009050 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA DDX52 http://www.ncbi.nlm.nih.gov/gene/11056 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009051 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA ETNK1 http://www.ncbi.nlm.nih.gov/gene/55500 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009052 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA EXOSC1 http://www.ncbi.nlm.nih.gov/gene/51013 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009053 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA FBXO45 http://www.ncbi.nlm.nih.gov/gene/200933 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009054 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA FLNA http://www.ncbi.nlm.nih.gov/gene/2316 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009055 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA HDGF http://www.ncbi.nlm.nih.gov/gene/3068 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009056 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA HSPA4 http://www.ncbi.nlm.nih.gov/gene/3308 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009057 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA IL21R http://www.ncbi.nlm.nih.gov/gene/50615 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009058 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA INTS6 http://www.ncbi.nlm.nih.gov/gene/26512 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009059 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA IRF1 http://www.ncbi.nlm.nih.gov/gene/3659 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009060 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA KIAA0831 http://www.ncbi.nlm.nih.gov/gene/22863 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009061 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA KLHL18 http://www.ncbi.nlm.nih.gov/gene/23276 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009062 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA LCOR http://www.ncbi.nlm.nih.gov/gene/84458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009063 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA PHF20L1 http://www.ncbi.nlm.nih.gov/gene/51105 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009064 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA PLXNB2 http://www.ncbi.nlm.nih.gov/gene/23654 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009065 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA POGK http://www.ncbi.nlm.nih.gov/gene/57645 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009066 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA QSER1 http://www.ncbi.nlm.nih.gov/gene/79832 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009067 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA RAB10 http://www.ncbi.nlm.nih.gov/gene/10890 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009068 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA RABL3 http://www.ncbi.nlm.nih.gov/gene/285282 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009069 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA RASSF8 http://www.ncbi.nlm.nih.gov/gene/11228 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009070 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA RNF168 http://www.ncbi.nlm.nih.gov/gene/165918 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009071 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA SLC30A6 http://www.ncbi.nlm.nih.gov/gene/55676 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009072 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA SNX29 http://www.ncbi.nlm.nih.gov/gene/92017 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009073 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA TMED7 http://www.ncbi.nlm.nih.gov/gene/353376 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009074 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA TNRC6B http://www.ncbi.nlm.nih.gov/gene/23112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009075 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA UBE2V1 http://www.ncbi.nlm.nih.gov/gene/387522 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009076 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA VPS37A http://www.ncbi.nlm.nih.gov/gene/137492 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009077 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA YWHAZ http://www.ncbi.nlm.nih.gov/gene/7534 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009078 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA ZBTB34 http://www.ncbi.nlm.nih.gov/gene/403341 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009079 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA ZNF28 http://www.ncbi.nlm.nih.gov/gene/7576 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009080 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-1 - Host mRNA ZNF724P http://www.ncbi.nlm.nih.gov/gene/440519 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009081 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA SEPT2 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009082 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA ACBD3 http://www.ncbi.nlm.nih.gov/gene/64746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009083 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA ACTR3 http://www.ncbi.nlm.nih.gov/gene/10096 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009084 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA ANKIB1 http://www.ncbi.nlm.nih.gov/gene/54467 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009085 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA AZIN1 http://www.ncbi.nlm.nih.gov/gene/51582 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009086 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA BAZ2A http://www.ncbi.nlm.nih.gov/gene/11176 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009087 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA C22orf29 http://www.ncbi.nlm.nih.gov/gene/79680 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009088 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA CACNA2D1 http://www.ncbi.nlm.nih.gov/gene/781 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009089 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA CCNL1 http://www.ncbi.nlm.nih.gov/gene/57018 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009090 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA COMMD2 http://www.ncbi.nlm.nih.gov/gene/51122 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009091 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA CYCS http://www.ncbi.nlm.nih.gov/gene/54205 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009092 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA DEF8 http://www.ncbi.nlm.nih.gov/gene/54849 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009093 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA DLG5 http://www.ncbi.nlm.nih.gov/gene/9231 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009094 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA GOLGA4 http://www.ncbi.nlm.nih.gov/gene/2803 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009095 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA GPR172A http://www.ncbi.nlm.nih.gov/gene/79581 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009096 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA IL21R http://www.ncbi.nlm.nih.gov/gene/50615 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009097 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA IRF1 http://www.ncbi.nlm.nih.gov/gene/3659 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009098 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA KBTBD4 http://www.ncbi.nlm.nih.gov/gene/55709 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009099 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA KIAA1826 http://www.ncbi.nlm.nih.gov/gene/84437 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009100 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA LCOR http://www.ncbi.nlm.nih.gov/gene/84458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009101 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA MGST1 http://www.ncbi.nlm.nih.gov/gene/4257 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009102 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA PLXNB2 http://www.ncbi.nlm.nih.gov/gene/23654 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009103 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA POGK http://www.ncbi.nlm.nih.gov/gene/57645 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009104 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA PPP1R12B http://www.ncbi.nlm.nih.gov/gene/4660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009105 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA RAB10 http://www.ncbi.nlm.nih.gov/gene/10890 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009106 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA RANGAP1 http://www.ncbi.nlm.nih.gov/gene/5905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009107 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA RNF24 http://www.ncbi.nlm.nih.gov/gene/11237 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009108 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA SLC30A6 http://www.ncbi.nlm.nih.gov/gene/55676 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009109 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA STK35 http://www.ncbi.nlm.nih.gov/gene/140901 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009110 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA TMED4 http://www.ncbi.nlm.nih.gov/gene/222068 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009111 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA TMED7 http://www.ncbi.nlm.nih.gov/gene/353376 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009112 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA TMPPE http://www.ncbi.nlm.nih.gov/gene/643853 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009113 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA TRAF3 http://www.ncbi.nlm.nih.gov/gene/7187 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009114 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA UBE2V1 http://www.ncbi.nlm.nih.gov/gene/387522 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009115 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA VPS37A http://www.ncbi.nlm.nih.gov/gene/137492 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009116 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA ZBTB34 http://www.ncbi.nlm.nih.gov/gene/403341 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009117 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA ZNF451 http://www.ncbi.nlm.nih.gov/gene/26036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009118 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA ZNF588 http://www.ncbi.nlm.nih.gov/gene/51427 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009119 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 BC-3 - Host mRNA ZNF714 http://www.ncbi.nlm.nih.gov/gene/148206 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009120 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K12-10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 - - Host Protein CDKN1B http://www.ncbi.nlm.nih.gov/gene/1027 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00009121 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K12-10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 - - Host Protein CTNND1 http://www.ncbi.nlm.nih.gov/gene/1500 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00009122 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K12-10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 - - Host Protein MTUS1 http://www.ncbi.nlm.nih.gov/gene/57509 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00009123 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K12-10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 - - Host Protein PKN2 http://www.ncbi.nlm.nih.gov/gene/5586 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00009124 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K12-10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 - - Host Protein SOS1 http://www.ncbi.nlm.nih.gov/gene/6654 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00009125 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K12-10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 - - Host Protein TPD52 http://www.ncbi.nlm.nih.gov/gene/7163 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00009126 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K12-10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 - - Host Protein ZFYVE9 http://www.ncbi.nlm.nih.gov/gene/9372 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00009127 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K12-10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 - - Host mRNA BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009128 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K12-10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 - - Host Protein BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00009129 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-10b(miR-K12-10b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002473 - - Host mRNA BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VHID00009130 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC3 - Host mRNA Bach1 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009131 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC3 - Host mRNA CEBPB http://www.ncbi.nlm.nih.gov/gene/1051 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009132 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC3 - Host mRNA FOS http://www.ncbi.nlm.nih.gov/gene/2353 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009133 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BCBL1 - Host mRNA Bach1 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009134 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BCBL1 - Host mRNA CEBPB http://www.ncbi.nlm.nih.gov/gene/1051 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009135 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BCBL1 - Host mRNA FOS http://www.ncbi.nlm.nih.gov/gene/2353 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009136 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BCBL1 - Host mRNA SLA http://www.ncbi.nlm.nih.gov/gene/6503 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009137 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BCBL1 - Host mRNA THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009138 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host Protein P21 http://www.ncbi.nlm.nih.gov/gene/644914 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00009139 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host Protein THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00009140 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host Protein MAF http://www.ncbi.nlm.nih.gov/gene/4094 - Iferase reporter assays, miRNA target prediction analysis, KSHV production and infection of LECs, qPCR and qRT-PCR, Western blotting, Gene expression and miRNA microarray profiling, Subcloning of KSHV miRNAs into pSIN-MCS, GSEA, Gene expression and miRNA microarray. 20080955 MAF is a target for KSHV-encoded miRNAs.Although miR-K12-6 and miR-K12-11 induced MAF repression, the strongest down-regulation was caused by the entire cluster . VHID00009141 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host Protein THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00009142 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ABL2 http://www.ncbi.nlm.nih.gov/gene/27 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009143 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ACTR10 http://www.ncbi.nlm.nih.gov/gene/55860 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009144 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ADNP http://www.ncbi.nlm.nih.gov/gene/23394 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009145 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA AFF4 http://www.ncbi.nlm.nih.gov/gene/27125 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009146 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA AIMP1 http://www.ncbi.nlm.nih.gov/gene/9255 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009147 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ANKFY1 http://www.ncbi.nlm.nih.gov/gene/51479 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009148 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ANKRD40 http://www.ncbi.nlm.nih.gov/gene/91369 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009149 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ANXA2 http://www.ncbi.nlm.nih.gov/gene/305 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009150 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA AP1GBP1 http://www.ncbi.nlm.nih.gov/gene/11276 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009151 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ARHGAP18 http://www.ncbi.nlm.nih.gov/gene/93663 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009152 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ARL15 http://www.ncbi.nlm.nih.gov/gene/54622 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009153 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ARL5B http://www.ncbi.nlm.nih.gov/gene/221079 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009154 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ARL6IP5 http://www.ncbi.nlm.nih.gov/gene/10550 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009155 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ARL8B http://www.ncbi.nlm.nih.gov/gene/55207 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009156 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ASAP1 http://www.ncbi.nlm.nih.gov/gene/50807 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009157 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ATP6V1C1 http://www.ncbi.nlm.nih.gov/gene/528 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009158 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ATP6V1G1 http://www.ncbi.nlm.nih.gov/gene/9550 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009159 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ATP9A http://www.ncbi.nlm.nih.gov/gene/10079 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009160 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ATXN1L http://www.ncbi.nlm.nih.gov/gene/342371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009161 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA AUH http://www.ncbi.nlm.nih.gov/gene/549 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009162 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA AZIN1 http://www.ncbi.nlm.nih.gov/gene/51582 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009163 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA BACH1 http://www.ncbi.nlm.nih.gov/gene/571 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009164 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA BBS10 http://www.ncbi.nlm.nih.gov/gene/79738 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009165 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA BET1 http://www.ncbi.nlm.nih.gov/gene/100128542 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009166 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA BNC2 http://www.ncbi.nlm.nih.gov/gene/54796 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009167 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA BRWD1 http://www.ncbi.nlm.nih.gov/gene/54014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009168 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA BTBD1 http://www.ncbi.nlm.nih.gov/gene/53339 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009169 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA BTN2A2 http://www.ncbi.nlm.nih.gov/gene/10385 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009170 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA C10orf12 http://www.ncbi.nlm.nih.gov/gene/26148 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009171 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA C11orf30 http://www.ncbi.nlm.nih.gov/gene/56946 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009172 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA C1orf103 http://www.ncbi.nlm.nih.gov/gene/55791 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009173 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA C1orf55 http://www.ncbi.nlm.nih.gov/gene/163859 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009174 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA C1orf63 http://www.ncbi.nlm.nih.gov/gene/57035 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009175 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA C20orf177 http://www.ncbi.nlm.nih.gov/gene/63939 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009176 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA C3orf23 http://www.ncbi.nlm.nih.gov/gene/285343 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009177 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA C5orf24 http://www.ncbi.nlm.nih.gov/gene/134553 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009178 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA C5orf41 http://www.ncbi.nlm.nih.gov/gene/153222 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009179 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA C8orf44 http://www.ncbi.nlm.nih.gov/gene/56260 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009180 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA C9orf5 http://www.ncbi.nlm.nih.gov/gene/23731 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009181 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CA13 http://www.ncbi.nlm.nih.gov/gene/377677 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009182 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CASP8AP2 http://www.ncbi.nlm.nih.gov/gene/9994 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009183 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CASP9 http://www.ncbi.nlm.nih.gov/gene/842 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009184 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CBL http://www.ncbi.nlm.nih.gov/gene/867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009185 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CBR4 http://www.ncbi.nlm.nih.gov/gene/84869 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009186 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CCDC126 http://www.ncbi.nlm.nih.gov/gene/90693 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009187 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CCT2 http://www.ncbi.nlm.nih.gov/gene/10576 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009188 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CD274 http://www.ncbi.nlm.nih.gov/gene/29126 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009189 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CD59 http://www.ncbi.nlm.nih.gov/gene/966 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009190 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CDC42EP4 http://www.ncbi.nlm.nih.gov/gene/23580 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009191 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CDC42SE2 http://www.ncbi.nlm.nih.gov/gene/56990 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009192 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CDC73 http://www.ncbi.nlm.nih.gov/gene/79577 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009193 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CFL2 http://www.ncbi.nlm.nih.gov/gene/1073 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009194 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CHD7 http://www.ncbi.nlm.nih.gov/gene/55636 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009195 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CHD8 http://www.ncbi.nlm.nih.gov/gene/57680 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009196 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CIAPIN1 http://www.ncbi.nlm.nih.gov/gene/57019 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009197 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CLCN3 http://www.ncbi.nlm.nih.gov/gene/1182 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009198 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CLCN5 http://www.ncbi.nlm.nih.gov/gene/1184 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009199 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CLUAP1 http://www.ncbi.nlm.nih.gov/gene/23059 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009200 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CNIH http://www.ncbi.nlm.nih.gov/gene/10175 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009201 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CNOT6L http://www.ncbi.nlm.nih.gov/gene/246175 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009202 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA COX11 http://www.ncbi.nlm.nih.gov/gene/1353 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009203 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CPNE3 http://www.ncbi.nlm.nih.gov/gene/8895 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009204 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CREG1 http://www.ncbi.nlm.nih.gov/gene/8804 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009205 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CRLF3 http://www.ncbi.nlm.nih.gov/gene/51379 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009206 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CSNK1A1 http://www.ncbi.nlm.nih.gov/gene/1452 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009207 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CSRNP2 http://www.ncbi.nlm.nih.gov/gene/81566 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009208 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CTHRC1 http://www.ncbi.nlm.nih.gov/gene/115908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009209 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CTSS http://www.ncbi.nlm.nih.gov/gene/1520 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009210 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CTTNBP2NL http://www.ncbi.nlm.nih.gov/gene/55917 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009211 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CUX1 http://www.ncbi.nlm.nih.gov/gene/1523 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009212 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CXorf23 http://www.ncbi.nlm.nih.gov/gene/256643 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009213 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CXorf39 http://www.ncbi.nlm.nih.gov/gene/139231 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009214 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CYB561D1 http://www.ncbi.nlm.nih.gov/gene/284613 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009215 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA CYP2U1 http://www.ncbi.nlm.nih.gov/gene/113612 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009216 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA DBF4 http://www.ncbi.nlm.nih.gov/gene/10926 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009217 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA DCUN1D2 http://www.ncbi.nlm.nih.gov/gene/55208 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009218 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA DCUN1D3 http://www.ncbi.nlm.nih.gov/gene/123879 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009219 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA DDX17 http://www.ncbi.nlm.nih.gov/gene/10521 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009220 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA DIS3L http://www.ncbi.nlm.nih.gov/gene/115752 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009221 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA DIXDC1 http://www.ncbi.nlm.nih.gov/gene/85458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009222 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA DMTF1 http://www.ncbi.nlm.nih.gov/gene/9988 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009223 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA DMXL2 http://www.ncbi.nlm.nih.gov/gene/23312 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009224 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA DNAJC19 http://www.ncbi.nlm.nih.gov/gene/131118 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009225 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA DPY19L1 http://www.ncbi.nlm.nih.gov/gene/23333 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009226 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA DSG2 http://www.ncbi.nlm.nih.gov/gene/1829 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009227 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA DUSP14 http://www.ncbi.nlm.nih.gov/gene/11072 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009228 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA E2F2 http://www.ncbi.nlm.nih.gov/gene/1870 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009229 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA EDEM3 http://www.ncbi.nlm.nih.gov/gene/80267 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009230 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA EEF2 http://www.ncbi.nlm.nih.gov/gene/1938 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009231 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA EGLN1 http://www.ncbi.nlm.nih.gov/gene/54583 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009232 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ELK3 http://www.ncbi.nlm.nih.gov/gene/2004 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009233 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ELK4 http://www.ncbi.nlm.nih.gov/gene/2005 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009234 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ENTPD7 http://www.ncbi.nlm.nih.gov/gene/57089 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009235 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ETV3 http://www.ncbi.nlm.nih.gov/gene/2117 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009236 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA EXOC8 http://www.ncbi.nlm.nih.gov/gene/149371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009237 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA EYA4 http://www.ncbi.nlm.nih.gov/gene/2070 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009238 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA FAM105B http://www.ncbi.nlm.nih.gov/gene/90268 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009239 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA FAM160B1 http://www.ncbi.nlm.nih.gov/gene/57700 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009240 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA FAM69A http://www.ncbi.nlm.nih.gov/gene/388650 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009241 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA FAR1 http://www.ncbi.nlm.nih.gov/gene/84188 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009242 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA FBXO11 http://www.ncbi.nlm.nih.gov/gene/80204 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009243 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA FBXO48 http://www.ncbi.nlm.nih.gov/gene/554251 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009244 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA FEM1C http://www.ncbi.nlm.nih.gov/gene/56929 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009245 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA FITM2 http://www.ncbi.nlm.nih.gov/gene/128486 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009246 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA FMNL2 http://www.ncbi.nlm.nih.gov/gene/114793 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009247 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA FNIP1 http://www.ncbi.nlm.nih.gov/gene/96459 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009248 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA FOS http://www.ncbi.nlm.nih.gov/gene/2353 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009249 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA FOSL2 http://www.ncbi.nlm.nih.gov/gene/2355 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009250 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA FOXK1 http://www.ncbi.nlm.nih.gov/gene/221937 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009251 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA FSTL5 http://www.ncbi.nlm.nih.gov/gene/56884 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009252 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA FUBP1 http://www.ncbi.nlm.nih.gov/gene/8880 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009253 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA GALT http://www.ncbi.nlm.nih.gov/gene/2592 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009254 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA GLT8D3 http://www.ncbi.nlm.nih.gov/gene/283464 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009255 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA GLUL http://www.ncbi.nlm.nih.gov/gene/2752 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009256 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA GMNN http://www.ncbi.nlm.nih.gov/gene/51053 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009257 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA GNA13 http://www.ncbi.nlm.nih.gov/gene/10672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009258 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA GOLM1 http://www.ncbi.nlm.nih.gov/gene/51280 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009259 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA GOPC http://www.ncbi.nlm.nih.gov/gene/57120 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009260 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA GPSM2 http://www.ncbi.nlm.nih.gov/gene/29899 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009261 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA GRIP1 http://www.ncbi.nlm.nih.gov/gene/23426 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009262 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA GYG1 http://www.ncbi.nlm.nih.gov/gene/2992 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009263 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA HCFC2 http://www.ncbi.nlm.nih.gov/gene/29915 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009264 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA HCN3 http://www.ncbi.nlm.nih.gov/gene/57657 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009265 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA HDX http://www.ncbi.nlm.nih.gov/gene/139324 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009266 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA HELQ http://www.ncbi.nlm.nih.gov/gene/113510 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009267 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA HIBCH http://www.ncbi.nlm.nih.gov/gene/26275 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009268 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA HLA-DPA1 http://www.ncbi.nlm.nih.gov/gene/3113 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009269 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA HMGCS1 http://www.ncbi.nlm.nih.gov/gene/3157 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009270 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA HSDL1 http://www.ncbi.nlm.nih.gov/gene/83693 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009271 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA IL1RAP http://www.ncbi.nlm.nih.gov/gene/3556 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009272 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA IL6ST http://www.ncbi.nlm.nih.gov/gene/3572 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009273 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA INO80D http://www.ncbi.nlm.nih.gov/gene/54891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009274 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA IRF2BP2 http://www.ncbi.nlm.nih.gov/gene/359948 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009275 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ITGAV http://www.ncbi.nlm.nih.gov/gene/3685 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009276 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA JARID2 http://www.ncbi.nlm.nih.gov/gene/3720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009277 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA KAT2A http://www.ncbi.nlm.nih.gov/gene/2648 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009278 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA KBTBD2 http://www.ncbi.nlm.nih.gov/gene/25948 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009279 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA KCTD7 http://www.ncbi.nlm.nih.gov/gene/154881 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009280 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA KDM5B http://www.ncbi.nlm.nih.gov/gene/10765 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009281 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA KIAA1267 http://www.ncbi.nlm.nih.gov/gene/284058 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009282 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA KIAA1704 http://www.ncbi.nlm.nih.gov/gene/55425 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009283 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA KIF14 http://www.ncbi.nlm.nih.gov/gene/9928 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009284 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA KIF20B http://www.ncbi.nlm.nih.gov/gene/9585 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009285 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA KIF3A http://www.ncbi.nlm.nih.gov/gene/11127 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009286 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA KIFC2 http://www.ncbi.nlm.nih.gov/gene/90990 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009287 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA KLF3 http://www.ncbi.nlm.nih.gov/gene/51274 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009288 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA KLHDC5 http://www.ncbi.nlm.nih.gov/gene/57542 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009289 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA KLHL8 http://www.ncbi.nlm.nih.gov/gene/57563 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009290 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA KPNA1 http://www.ncbi.nlm.nih.gov/gene/3836 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009291 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA KRAS http://www.ncbi.nlm.nih.gov/gene/3845 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009292 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA L2HGDH http://www.ncbi.nlm.nih.gov/gene/79944 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009293 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA LASS6 http://www.ncbi.nlm.nih.gov/gene/253782 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009294 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA LATS2 http://www.ncbi.nlm.nih.gov/gene/26524 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009295 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA LCORL http://www.ncbi.nlm.nih.gov/gene/254251 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009296 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA LIN28B http://www.ncbi.nlm.nih.gov/gene/389421 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009297 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA LNX2 http://www.ncbi.nlm.nih.gov/gene/222484 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009298 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA LPHN3 http://www.ncbi.nlm.nih.gov/gene/23284 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009299 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA LRRC58 http://www.ncbi.nlm.nih.gov/gene/116064 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009300 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA LRRC59 http://www.ncbi.nlm.nih.gov/gene/55379 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009301 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA LYSMD3 http://www.ncbi.nlm.nih.gov/gene/116068 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009302 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA MAP3K13 http://www.ncbi.nlm.nih.gov/gene/9175 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009303 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA MAP3K14 http://www.ncbi.nlm.nih.gov/gene/9020 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009304 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA MAP3K2 http://www.ncbi.nlm.nih.gov/gene/10746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009305 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA MAP3K7IP2 http://www.ncbi.nlm.nih.gov/gene/23118 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009306 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA MECP2 http://www.ncbi.nlm.nih.gov/gene/4204 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009307 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA MEX3C http://www.ncbi.nlm.nih.gov/gene/51320 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009308 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA MIDN http://www.ncbi.nlm.nih.gov/gene/90007 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009309 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA MIER1 http://www.ncbi.nlm.nih.gov/gene/57708 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009310 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA MIER3 http://www.ncbi.nlm.nih.gov/gene/166968 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009311 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA MITF http://www.ncbi.nlm.nih.gov/gene/4286 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009312 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA MKLN1 http://www.ncbi.nlm.nih.gov/gene/4289 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009313 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA MLLT4 http://www.ncbi.nlm.nih.gov/gene/4301 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009314 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA MPP5 http://www.ncbi.nlm.nih.gov/gene/64398 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009315 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA MYB http://www.ncbi.nlm.nih.gov/gene/4602 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009316 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA MYD88 http://www.ncbi.nlm.nih.gov/gene/4615 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009317 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA MYST3 http://www.ncbi.nlm.nih.gov/gene/7994 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009318 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA NAPEPLD http://www.ncbi.nlm.nih.gov/gene/222236 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009319 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA NARS http://www.ncbi.nlm.nih.gov/gene/4677 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009320 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA NAT13 http://www.ncbi.nlm.nih.gov/gene/80218 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009321 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA NDFIP1 http://www.ncbi.nlm.nih.gov/gene/80762 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009322 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA NFIA http://www.ncbi.nlm.nih.gov/gene/4774 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009323 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009324 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA NR1D2 http://www.ncbi.nlm.nih.gov/gene/9975 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009325 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA NR1H3 http://www.ncbi.nlm.nih.gov/gene/10062 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009326 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA NUFIP2 http://www.ncbi.nlm.nih.gov/gene/57532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009327 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA NUP155 http://www.ncbi.nlm.nih.gov/gene/9631 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009328 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA NUP43 http://www.ncbi.nlm.nih.gov/gene/348995 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009329 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA OGT http://www.ncbi.nlm.nih.gov/gene/8473 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009330 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PAPOLA http://www.ncbi.nlm.nih.gov/gene/10914 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009331 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PCDHB10 http://www.ncbi.nlm.nih.gov/gene/56126 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009332 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PCMTD1 http://www.ncbi.nlm.nih.gov/gene/115294 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009333 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PDCD4 http://www.ncbi.nlm.nih.gov/gene/27250 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009334 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PDCD6 http://www.ncbi.nlm.nih.gov/gene/10016 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009335 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PDE12 http://www.ncbi.nlm.nih.gov/gene/201626 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009336 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PDLIM5 http://www.ncbi.nlm.nih.gov/gene/10611 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009337 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PEBP1 http://www.ncbi.nlm.nih.gov/gene/5037 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009338 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PET112L http://www.ncbi.nlm.nih.gov/gene/5188 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009339 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PHC3 http://www.ncbi.nlm.nih.gov/gene/80012 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009340 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PHF17 http://www.ncbi.nlm.nih.gov/gene/79960 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009341 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PHF6 http://www.ncbi.nlm.nih.gov/gene/84295 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009342 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PICALM http://www.ncbi.nlm.nih.gov/gene/8301 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009343 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PKIA http://www.ncbi.nlm.nih.gov/gene/5569 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009344 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PKN2 http://www.ncbi.nlm.nih.gov/gene/5586 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009345 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PLDN http://www.ncbi.nlm.nih.gov/gene/26258 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009346 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PLEKHB2 http://www.ncbi.nlm.nih.gov/gene/55041 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009347 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PNPT1 http://www.ncbi.nlm.nih.gov/gene/87178 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009348 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA POU2F1 http://www.ncbi.nlm.nih.gov/gene/5451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009349 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PPP2CB http://www.ncbi.nlm.nih.gov/gene/5516 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009350 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PPTC7 http://www.ncbi.nlm.nih.gov/gene/160760 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009351 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PSKH1 http://www.ncbi.nlm.nih.gov/gene/5681 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009352 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PTAR1 http://www.ncbi.nlm.nih.gov/gene/375743 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009353 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PTPN11 http://www.ncbi.nlm.nih.gov/gene/344593 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009354 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PTPRJ http://www.ncbi.nlm.nih.gov/gene/5795 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009355 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA PUS7L http://www.ncbi.nlm.nih.gov/gene/83448 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009356 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA RAB3GAP1 http://www.ncbi.nlm.nih.gov/gene/22930 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009357 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA RAPGEF2 http://www.ncbi.nlm.nih.gov/gene/9693 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009358 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA RAPH1 http://www.ncbi.nlm.nih.gov/gene/65059 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009359 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA RB1 http://www.ncbi.nlm.nih.gov/gene/5925 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009360 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA RBM47 http://www.ncbi.nlm.nih.gov/gene/54502 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009361 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA RC3H2 http://www.ncbi.nlm.nih.gov/gene/54542 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009362 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA RCHY1 http://www.ncbi.nlm.nih.gov/gene/25898 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009363 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA RECK http://www.ncbi.nlm.nih.gov/gene/8434 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009364 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA RFK http://www.ncbi.nlm.nih.gov/gene/55312 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009365 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA RGL1 http://www.ncbi.nlm.nih.gov/gene/23179 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009366 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA RGP1 http://www.ncbi.nlm.nih.gov/gene/9827 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009367 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA RIT1 http://www.ncbi.nlm.nih.gov/gene/6016 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009368 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA RNF146 http://www.ncbi.nlm.nih.gov/gene/81847 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009369 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA RNF213 http://www.ncbi.nlm.nih.gov/gene/57674 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009370 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA RNGTT http://www.ncbi.nlm.nih.gov/gene/8732 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009371 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA RORA http://www.ncbi.nlm.nih.gov/gene/6095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009372 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA RP2 http://www.ncbi.nlm.nih.gov/gene/6102 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009373 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA RPE http://www.ncbi.nlm.nih.gov/gene/729020 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009374 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA RPS6KA3 http://www.ncbi.nlm.nih.gov/gene/6197 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009375 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA RUFY2 http://www.ncbi.nlm.nih.gov/gene/55680 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009376 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA SACM1L http://www.ncbi.nlm.nih.gov/gene/22908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009377 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA SAP30L http://www.ncbi.nlm.nih.gov/gene/79685 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009378 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA SCAMP1 http://www.ncbi.nlm.nih.gov/gene/9522 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009379 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA SCRN3 http://www.ncbi.nlm.nih.gov/gene/79634 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009380 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA SERTAD2 http://www.ncbi.nlm.nih.gov/gene/9792 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009381 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA SETD7 http://www.ncbi.nlm.nih.gov/gene/80854 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009382 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA SH3PXD2A http://www.ncbi.nlm.nih.gov/gene/9644 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009383 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA SKIV2L2 http://www.ncbi.nlm.nih.gov/gene/23517 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009384 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA SLC30A1 http://www.ncbi.nlm.nih.gov/gene/7779 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009385 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA SLC35A1 http://www.ncbi.nlm.nih.gov/gene/10559 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009386 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA SLC35F2 http://www.ncbi.nlm.nih.gov/gene/54733 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009387 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA SLFN11 http://www.ncbi.nlm.nih.gov/gene/91607 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009388 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA SMAD2 http://www.ncbi.nlm.nih.gov/gene/4087 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009389 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA SMAD5 http://www.ncbi.nlm.nih.gov/gene/4090 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009390 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA SNX29 http://www.ncbi.nlm.nih.gov/gene/92017 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009391 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA SOCS5 http://www.ncbi.nlm.nih.gov/gene/9655 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009392 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA SP1 http://www.ncbi.nlm.nih.gov/gene/6667 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009393 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA SP3 http://www.ncbi.nlm.nih.gov/gene/6670 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009394 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA SPIN1 http://www.ncbi.nlm.nih.gov/gene/10927 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009395 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA STAG2 http://www.ncbi.nlm.nih.gov/gene/10735 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009396 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA STARD5 http://www.ncbi.nlm.nih.gov/gene/80765 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009397 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA STRN3 http://www.ncbi.nlm.nih.gov/gene/29966 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009398 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA SYT1 http://www.ncbi.nlm.nih.gov/gene/6857 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009399 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TAF5L http://www.ncbi.nlm.nih.gov/gene/27097 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009400 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TBC1D15 http://www.ncbi.nlm.nih.gov/gene/64786 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009401 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TCF12 http://www.ncbi.nlm.nih.gov/gene/6938 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009402 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TCF4 http://www.ncbi.nlm.nih.gov/gene/6925 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009403 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TCF7L2 http://www.ncbi.nlm.nih.gov/gene/6934 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009404 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TCTN3 http://www.ncbi.nlm.nih.gov/gene/26123 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009405 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TET1 http://www.ncbi.nlm.nih.gov/gene/80312 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009406 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TET2 http://www.ncbi.nlm.nih.gov/gene/54790 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009407 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TFDP2 http://www.ncbi.nlm.nih.gov/gene/7029 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009408 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TMEM33 http://www.ncbi.nlm.nih.gov/gene/55161 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009409 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TMX3 http://www.ncbi.nlm.nih.gov/gene/54495 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009410 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TNPO1 http://www.ncbi.nlm.nih.gov/gene/3842 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009411 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TP53INP1 http://www.ncbi.nlm.nih.gov/gene/94241 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009412 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TPD52 http://www.ncbi.nlm.nih.gov/gene/7163 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009413 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TPRKB http://www.ncbi.nlm.nih.gov/gene/51002 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009414 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TRAM1 http://www.ncbi.nlm.nih.gov/gene/23471 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009415 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TRIM32 http://www.ncbi.nlm.nih.gov/gene/22954 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009416 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TRIP13 http://www.ncbi.nlm.nih.gov/gene/9319 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009417 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TRUB1 http://www.ncbi.nlm.nih.gov/gene/142940 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009418 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TTC7A http://www.ncbi.nlm.nih.gov/gene/57217 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009419 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TWF1 http://www.ncbi.nlm.nih.gov/gene/5756 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009420 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA TXNRD1 http://www.ncbi.nlm.nih.gov/gene/7296 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009421 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA UBE2D3 http://www.ncbi.nlm.nih.gov/gene/100037280 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009422 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA UBL3 http://www.ncbi.nlm.nih.gov/gene/5412 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009423 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA UBR4 http://www.ncbi.nlm.nih.gov/gene/23352 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009424 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA UBXN2B http://www.ncbi.nlm.nih.gov/gene/137886 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009425 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA UPF2 http://www.ncbi.nlm.nih.gov/gene/26019 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009426 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA UQCRB http://www.ncbi.nlm.nih.gov/gene/442454 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009427 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA USP30 http://www.ncbi.nlm.nih.gov/gene/84749 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009428 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA VAMP3 http://www.ncbi.nlm.nih.gov/gene/9341 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009429 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA VCPIP1 http://www.ncbi.nlm.nih.gov/gene/80124 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009430 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA VEZF1 http://www.ncbi.nlm.nih.gov/gene/7716 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009431 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA VMA21 http://www.ncbi.nlm.nih.gov/gene/203547 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009432 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA VPS36 http://www.ncbi.nlm.nih.gov/gene/51028 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009433 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA VTI1A http://www.ncbi.nlm.nih.gov/gene/143187 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009434 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA WDR82 http://www.ncbi.nlm.nih.gov/gene/80335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009435 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA WEE1 http://www.ncbi.nlm.nih.gov/gene/7465 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009436 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA WWC1 http://www.ncbi.nlm.nih.gov/gene/23286 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009437 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA WWP1 http://www.ncbi.nlm.nih.gov/gene/11059 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009438 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA XIAP http://www.ncbi.nlm.nih.gov/gene/331 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009439 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA XPNPEP1 http://www.ncbi.nlm.nih.gov/gene/7511 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009440 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA YIPF6 http://www.ncbi.nlm.nih.gov/gene/286451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009441 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA YME1L1 http://www.ncbi.nlm.nih.gov/gene/10730 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009442 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA YWHAE http://www.ncbi.nlm.nih.gov/gene/7531 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009443 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ZBTB38 http://www.ncbi.nlm.nih.gov/gene/253461 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009444 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ZKSCAN5 http://www.ncbi.nlm.nih.gov/gene/23660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009445 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ZNF238 http://www.ncbi.nlm.nih.gov/gene/10472 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009446 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ZNF431 http://www.ncbi.nlm.nih.gov/gene/170959 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009447 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ZNF492 http://www.ncbi.nlm.nih.gov/gene/100130108 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009448 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ZNF518A http://www.ncbi.nlm.nih.gov/gene/9849 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009449 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ZNF605 http://www.ncbi.nlm.nih.gov/gene/100289635 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009450 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ZNF621 http://www.ncbi.nlm.nih.gov/gene/285268 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009451 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ZNF644 http://www.ncbi.nlm.nih.gov/gene/84146 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009452 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ZNF652 http://www.ncbi.nlm.nih.gov/gene/22834 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009453 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ZNF678 http://www.ncbi.nlm.nih.gov/gene/339500 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009454 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ZNF680 http://www.ncbi.nlm.nih.gov/gene/340252 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009455 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ZNF701 http://www.ncbi.nlm.nih.gov/gene/55762 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009456 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ZNF714 http://www.ncbi.nlm.nih.gov/gene/148206 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009457 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ZNF721 http://www.ncbi.nlm.nih.gov/gene/170960 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009458 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-1 - Host mRNA ZNF724P http://www.ncbi.nlm.nih.gov/gene/440519 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009459 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA ANKFY1 http://www.ncbi.nlm.nih.gov/gene/51479 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009460 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA APAF1 http://www.ncbi.nlm.nih.gov/gene/317 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009461 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA ARID2 http://www.ncbi.nlm.nih.gov/gene/196528 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009462 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA ARL6IP5 http://www.ncbi.nlm.nih.gov/gene/10550 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009463 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA ATRNL1 http://www.ncbi.nlm.nih.gov/gene/26033 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009464 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA ATRX http://www.ncbi.nlm.nih.gov/gene/546 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009465 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA ATXN1L http://www.ncbi.nlm.nih.gov/gene/342371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009466 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA BACH1 http://www.ncbi.nlm.nih.gov/gene/571 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009467 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA BTN2A2 http://www.ncbi.nlm.nih.gov/gene/10385 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009468 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA C1orf55 http://www.ncbi.nlm.nih.gov/gene/163859 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009469 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA C2orf18 http://www.ncbi.nlm.nih.gov/gene/54978 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009470 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA C8orf44 http://www.ncbi.nlm.nih.gov/gene/56260 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009471 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA CA13 http://www.ncbi.nlm.nih.gov/gene/377677 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009472 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA CDC42EP4 http://www.ncbi.nlm.nih.gov/gene/23580 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009473 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA CEBPB http://www.ncbi.nlm.nih.gov/gene/1051 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009474 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA CLUAP1 http://www.ncbi.nlm.nih.gov/gene/23059 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009475 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA CTTNBP2NL http://www.ncbi.nlm.nih.gov/gene/55917 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009476 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA CUX1 http://www.ncbi.nlm.nih.gov/gene/1523 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009477 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA CYB561D1 http://www.ncbi.nlm.nih.gov/gene/284613 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009478 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA DFFA http://www.ncbi.nlm.nih.gov/gene/1676 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009479 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA EGLN1 http://www.ncbi.nlm.nih.gov/gene/54583 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009480 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA FAM105A http://www.ncbi.nlm.nih.gov/gene/54491 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009481 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA FAM133A http://www.ncbi.nlm.nih.gov/gene/286499 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009482 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA FBXO48 http://www.ncbi.nlm.nih.gov/gene/554251 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009483 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA FEM1B http://www.ncbi.nlm.nih.gov/gene/10116 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009484 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA FEM1C http://www.ncbi.nlm.nih.gov/gene/56929 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009485 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA FITM2 http://www.ncbi.nlm.nih.gov/gene/128486 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009486 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA FNTB http://www.ncbi.nlm.nih.gov/gene/2342 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009487 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA FOSL2 http://www.ncbi.nlm.nih.gov/gene/2355 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009488 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA GALT http://www.ncbi.nlm.nih.gov/gene/2592 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009489 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA GYG1 http://www.ncbi.nlm.nih.gov/gene/2992 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009490 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA IL17RB http://www.ncbi.nlm.nih.gov/gene/55540 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009491 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA IRF2BP2 http://www.ncbi.nlm.nih.gov/gene/359948 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009492 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA KBTBD11 http://www.ncbi.nlm.nih.gov/gene/9920 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009493 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA KBTBD2 http://www.ncbi.nlm.nih.gov/gene/25948 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009494 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA KIAA1462 http://www.ncbi.nlm.nih.gov/gene/57608 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009495 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA KLHDC5 http://www.ncbi.nlm.nih.gov/gene/57542 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009496 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA LCORL http://www.ncbi.nlm.nih.gov/gene/254251 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009497 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA LDLRAP1 http://www.ncbi.nlm.nih.gov/gene/26119 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009498 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA LIG4 http://www.ncbi.nlm.nih.gov/gene/3981 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009499 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA LNX2 http://www.ncbi.nlm.nih.gov/gene/222484 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009500 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA LRRC8B http://www.ncbi.nlm.nih.gov/gene/23507 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009501 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA MAP3K14 http://www.ncbi.nlm.nih.gov/gene/9020 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009502 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA MAP3K7IP2 http://www.ncbi.nlm.nih.gov/gene/23118 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009503 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA MDM2 http://www.ncbi.nlm.nih.gov/gene/4193 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009504 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA MEX3C http://www.ncbi.nlm.nih.gov/gene/51320 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009505 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA MIDN http://www.ncbi.nlm.nih.gov/gene/90007 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009506 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA MIER1 http://www.ncbi.nlm.nih.gov/gene/57708 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009507 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA MITF http://www.ncbi.nlm.nih.gov/gene/4286 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009508 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA MOCS2 http://www.ncbi.nlm.nih.gov/gene/4338 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009509 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA MPP5 http://www.ncbi.nlm.nih.gov/gene/64398 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009510 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA MYB http://www.ncbi.nlm.nih.gov/gene/4602 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009511 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA NARS http://www.ncbi.nlm.nih.gov/gene/4677 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009512 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA NDFIP1 http://www.ncbi.nlm.nih.gov/gene/80762 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009513 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA NHLRC2 http://www.ncbi.nlm.nih.gov/gene/374354 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009514 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA PDCD4 http://www.ncbi.nlm.nih.gov/gene/27250 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009515 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA PDE12 http://www.ncbi.nlm.nih.gov/gene/201626 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009516 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA PHF17 http://www.ncbi.nlm.nih.gov/gene/79960 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009517 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA PKN2 http://www.ncbi.nlm.nih.gov/gene/5586 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009518 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA PLEKHB2 http://www.ncbi.nlm.nih.gov/gene/55041 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009519 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA POU2F1 http://www.ncbi.nlm.nih.gov/gene/5451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009520 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA PPIL2 http://www.ncbi.nlm.nih.gov/gene/23759 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009521 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA PTAR1 http://www.ncbi.nlm.nih.gov/gene/375743 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009522 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA RCHY1 http://www.ncbi.nlm.nih.gov/gene/25898 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009523 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA RGP1 http://www.ncbi.nlm.nih.gov/gene/9827 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009524 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA RUFY2 http://www.ncbi.nlm.nih.gov/gene/55680 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009525 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA SAP30L http://www.ncbi.nlm.nih.gov/gene/79685 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009526 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA SKIV2L2 http://www.ncbi.nlm.nih.gov/gene/23517 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009527 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA SLC12A6 http://www.ncbi.nlm.nih.gov/gene/9990 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009528 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA SLC35F2 http://www.ncbi.nlm.nih.gov/gene/54733 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009529 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA SOCS5 http://www.ncbi.nlm.nih.gov/gene/9655 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009530 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA SP3 http://www.ncbi.nlm.nih.gov/gene/6670 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009531 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA STAG2 http://www.ncbi.nlm.nih.gov/gene/10735 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009532 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA STARD5 http://www.ncbi.nlm.nih.gov/gene/80765 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009533 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA TMEM33 http://www.ncbi.nlm.nih.gov/gene/55161 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009534 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA TP53INP1 http://www.ncbi.nlm.nih.gov/gene/94241 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009535 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA TRIM32 http://www.ncbi.nlm.nih.gov/gene/22954 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009536 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA TRIM36 http://www.ncbi.nlm.nih.gov/gene/55521 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009537 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA TRIM44 http://www.ncbi.nlm.nih.gov/gene/54765 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009538 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA TRIP13 http://www.ncbi.nlm.nih.gov/gene/9319 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009539 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA TSPAN5 http://www.ncbi.nlm.nih.gov/gene/10098 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009540 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA TWF1 http://www.ncbi.nlm.nih.gov/gene/5756 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009541 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA UBXN2B http://www.ncbi.nlm.nih.gov/gene/137886 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009542 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA UQCRB http://www.ncbi.nlm.nih.gov/gene/442454 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009543 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA VCPIP1 http://www.ncbi.nlm.nih.gov/gene/80124 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009544 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA VMA21 http://www.ncbi.nlm.nih.gov/gene/203547 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009545 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA VPS36 http://www.ncbi.nlm.nih.gov/gene/51028 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009546 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA WDR72 http://www.ncbi.nlm.nih.gov/gene/256764 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009547 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA WDR82 http://www.ncbi.nlm.nih.gov/gene/80335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009548 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA WEE1 http://www.ncbi.nlm.nih.gov/gene/7465 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009549 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA XIAP http://www.ncbi.nlm.nih.gov/gene/331 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009550 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA YIPF6 http://www.ncbi.nlm.nih.gov/gene/286451 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009551 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA ZBTB38 http://www.ncbi.nlm.nih.gov/gene/253461 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009552 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA ZNF254 http://www.ncbi.nlm.nih.gov/gene/9534 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009553 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA ZNF273 http://www.ncbi.nlm.nih.gov/gene/10793 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009554 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA ZNF431 http://www.ncbi.nlm.nih.gov/gene/170959 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009555 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA ZNF492 http://www.ncbi.nlm.nih.gov/gene/100130108 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009556 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA ZNF507 http://www.ncbi.nlm.nih.gov/gene/22847 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009557 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA ZNF652 http://www.ncbi.nlm.nih.gov/gene/22834 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009558 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA ZNF701 http://www.ncbi.nlm.nih.gov/gene/55762 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009559 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA ZNF714 http://www.ncbi.nlm.nih.gov/gene/148206 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009560 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC-3 - Host mRNA ZNF724P http://www.ncbi.nlm.nih.gov/gene/440519 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009561 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA AGTR1 http://www.ncbi.nlm.nih.gov/gene/185 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009562 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA AICDA http://www.ncbi.nlm.nih.gov/gene/57379 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009563 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA APAF1 http://www.ncbi.nlm.nih.gov/gene/317 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009564 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA ARFIP1 http://www.ncbi.nlm.nih.gov/gene/27236 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009565 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA ARID2 http://www.ncbi.nlm.nih.gov/gene/196528 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009566 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA ARL15 http://www.ncbi.nlm.nih.gov/gene/54622 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009567 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA ARL6IP5 http://www.ncbi.nlm.nih.gov/gene/10550 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009568 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA ARMC2 http://www.ncbi.nlm.nih.gov/gene/84071 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009569 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA ARNTL http://www.ncbi.nlm.nih.gov/gene/406 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009570 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA ARPC3 http://www.ncbi.nlm.nih.gov/gene/729494 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009571 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA BACH1 http://www.ncbi.nlm.nih.gov/gene/571 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009572 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA C10ORF104 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009573 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA C10ORF26 http://www.ncbi.nlm.nih.gov/gene/54838 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009574 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA C16orf62 http://www.ncbi.nlm.nih.gov/gene/57020 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009575 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA C1ORF103 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009576 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA C2orf3 http://www.ncbi.nlm.nih.gov/gene/6936 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009577 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA C3ORF18 http://www.ncbi.nlm.nih.gov/gene/51161 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009578 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA C5ORF44 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009579 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA CARD10 http://www.ncbi.nlm.nih.gov/gene/29775 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009580 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA CARHSP1 http://www.ncbi.nlm.nih.gov/gene/23589 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009581 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA CCDC41 http://www.ncbi.nlm.nih.gov/gene/51134 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009582 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA CCDC82 http://www.ncbi.nlm.nih.gov/gene/79780 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009583 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA CCR9 http://www.ncbi.nlm.nih.gov/gene/10803 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009584 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA CDH6 http://www.ncbi.nlm.nih.gov/gene/1004 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009585 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA CDKN1B http://www.ncbi.nlm.nih.gov/gene/1027 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009586 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA CEBPB http://www.ncbi.nlm.nih.gov/gene/1051 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009587 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA CHD9 http://www.ncbi.nlm.nih.gov/gene/80205 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009588 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA CIAPIN1 http://www.ncbi.nlm.nih.gov/gene/57019 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009589 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA CLUAP1 http://www.ncbi.nlm.nih.gov/gene/23059 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009590 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA CSF1R http://www.ncbi.nlm.nih.gov/gene/1436 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009591 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA CSNK1A1 http://www.ncbi.nlm.nih.gov/gene/1452 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009592 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA CUX1 http://www.ncbi.nlm.nih.gov/gene/1523 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009593 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA CYP2U1 http://www.ncbi.nlm.nih.gov/gene/113612 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009594 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA DCUN1D2 http://www.ncbi.nlm.nih.gov/gene/55208 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009595 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA DET1 http://www.ncbi.nlm.nih.gov/gene/55070 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009596 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA DHX40 http://www.ncbi.nlm.nih.gov/gene/100134387 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009597 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA E2F2 http://www.ncbi.nlm.nih.gov/gene/1870 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009598 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA EIF2C4 http://www.ncbi.nlm.nih.gov/gene/192670 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009599 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA ETS1 http://www.ncbi.nlm.nih.gov/gene/2113 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009600 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA EXOSC2 http://www.ncbi.nlm.nih.gov/gene/23404 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009601 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA FAM135A http://www.ncbi.nlm.nih.gov/gene/57579 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009602 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA FAM164C http://www.ncbi.nlm.nih.gov/gene/79696 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009603 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA FAM177A1 http://www.ncbi.nlm.nih.gov/gene/283635 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009604 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA FAM199X http://www.ncbi.nlm.nih.gov/gene/139231 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009605 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA FAM91A1 http://www.ncbi.nlm.nih.gov/gene/157769 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009606 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA FOS http://www.ncbi.nlm.nih.gov/gene/2353 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009607 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA FOXO3 http://www.ncbi.nlm.nih.gov/gene/2310 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009608 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA GABARAPL1 http://www.ncbi.nlm.nih.gov/gene/23710 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009609 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA GATM http://www.ncbi.nlm.nih.gov/gene/2628 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009610 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA GOLT1B http://www.ncbi.nlm.nih.gov/gene/51026 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009611 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA HAL http://www.ncbi.nlm.nih.gov/gene/3034 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009612 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA HBP1 http://www.ncbi.nlm.nih.gov/gene/26959 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009613 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA HIF1A http://www.ncbi.nlm.nih.gov/gene/3091 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009614 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA HIVEP2 http://www.ncbi.nlm.nih.gov/gene/3097 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009615 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA IKBKE http://www.ncbi.nlm.nih.gov/gene/9641 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009616 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA IKIP http://www.ncbi.nlm.nih.gov/gene/121457 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009617 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA IL17RB http://www.ncbi.nlm.nih.gov/gene/55540 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009618 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA INPP5D http://www.ncbi.nlm.nih.gov/gene/3635 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009619 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA INPP5F http://www.ncbi.nlm.nih.gov/gene/22876 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009620 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA INTS6 http://www.ncbi.nlm.nih.gov/gene/26512 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009621 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA JARID2 http://www.ncbi.nlm.nih.gov/gene/3720 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009622 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA KBTBD2 http://www.ncbi.nlm.nih.gov/gene/25948 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009623 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA KIAA0430 http://www.ncbi.nlm.nih.gov/gene/9665 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009624 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA KIAA1274 http://www.ncbi.nlm.nih.gov/gene/27143 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009625 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA KLHL5 http://www.ncbi.nlm.nih.gov/gene/51088 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009626 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA KLRA1 http://www.ncbi.nlm.nih.gov/gene/10748 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009627 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA KRCC1 http://www.ncbi.nlm.nih.gov/gene/51315 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009628 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA LCORL http://www.ncbi.nlm.nih.gov/gene/254251 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009629 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA LDOC1 http://www.ncbi.nlm.nih.gov/gene/23641 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009630 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA LIN7C http://www.ncbi.nlm.nih.gov/gene/55327 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009631 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA LNX2 http://www.ncbi.nlm.nih.gov/gene/222484 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009632 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA LRP1B http://www.ncbi.nlm.nih.gov/gene/53353 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009633 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA LRRC59 http://www.ncbi.nlm.nih.gov/gene/55379 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009634 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA LSM14A http://www.ncbi.nlm.nih.gov/gene/26065 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009635 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA MAF http://www.ncbi.nlm.nih.gov/gene/4094 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009636 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA MAP3K10 http://www.ncbi.nlm.nih.gov/gene/4294 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009637 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA MAP3K7IP2 http://www.ncbi.nlm.nih.gov/gene/23118 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009638 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA MASTL http://www.ncbi.nlm.nih.gov/gene/84930 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009639 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA MATR3 http://www.ncbi.nlm.nih.gov/gene/9782 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009640 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA MCM8 http://www.ncbi.nlm.nih.gov/gene/84515 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009641 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA MED13L http://www.ncbi.nlm.nih.gov/gene/23389 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009642 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA MEF2A http://www.ncbi.nlm.nih.gov/gene/4205 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009643 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA MITF http://www.ncbi.nlm.nih.gov/gene/4286 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009644 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA MLH1 http://www.ncbi.nlm.nih.gov/gene/4292 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009645 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA MORC3 http://www.ncbi.nlm.nih.gov/gene/23515 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009646 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA MPP5 http://www.ncbi.nlm.nih.gov/gene/64398 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009647 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA MRPL18 http://www.ncbi.nlm.nih.gov/gene/29074 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009648 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA MSH2 http://www.ncbi.nlm.nih.gov/gene/4436 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009649 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA MYD88 http://www.ncbi.nlm.nih.gov/gene/4615 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009650 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA MYLK http://www.ncbi.nlm.nih.gov/gene/4638 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009651 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA MYO10 http://www.ncbi.nlm.nih.gov/gene/4651 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009652 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA MYO1D http://www.ncbi.nlm.nih.gov/gene/4642 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009653 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA NARS http://www.ncbi.nlm.nih.gov/gene/4677 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009654 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA NKX3-1 http://www.ncbi.nlm.nih.gov/gene/4824 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009655 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA PAK2 http://www.ncbi.nlm.nih.gov/gene/5062 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009656 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA PCDH9 http://www.ncbi.nlm.nih.gov/gene/5101 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009657 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA PDCD4 http://www.ncbi.nlm.nih.gov/gene/27250 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009658 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA PHC2 http://www.ncbi.nlm.nih.gov/gene/1912 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009659 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA PHF14 http://www.ncbi.nlm.nih.gov/gene/9678 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009660 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA PICALM http://www.ncbi.nlm.nih.gov/gene/8301 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009661 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA PIK3CA http://www.ncbi.nlm.nih.gov/gene/5290 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009662 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA PKN2 http://www.ncbi.nlm.nih.gov/gene/5586 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009663 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA PLS1 http://www.ncbi.nlm.nih.gov/gene/5357 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009664 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA POLE3 http://www.ncbi.nlm.nih.gov/gene/54107 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009665 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA PRKAR1A http://www.ncbi.nlm.nih.gov/gene/5573 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009666 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA RAB11FIP2 http://www.ncbi.nlm.nih.gov/gene/22841 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009667 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA RAPGEF2 http://www.ncbi.nlm.nih.gov/gene/9693 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009668 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA RFK http://www.ncbi.nlm.nih.gov/gene/55312 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009669 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA RHEB http://www.ncbi.nlm.nih.gov/gene/6009 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009670 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA RNF123 http://www.ncbi.nlm.nih.gov/gene/63891 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009671 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA RPS6KA3 http://www.ncbi.nlm.nih.gov/gene/6197 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009672 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA RUNX2 http://www.ncbi.nlm.nih.gov/gene/860 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009673 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA SAMHD1 http://www.ncbi.nlm.nih.gov/gene/25939 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009674 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA SAP30L http://www.ncbi.nlm.nih.gov/gene/79685 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009675 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA SDCBP http://www.ncbi.nlm.nih.gov/gene/6386 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009676 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA SECISBP2 http://www.ncbi.nlm.nih.gov/gene/79048 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009677 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA SLA http://www.ncbi.nlm.nih.gov/gene/6503 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009678 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA SMAD1 http://www.ncbi.nlm.nih.gov/gene/4086 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009679 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA SMAD2 http://www.ncbi.nlm.nih.gov/gene/4087 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009680 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA SMAD5 http://www.ncbi.nlm.nih.gov/gene/4090 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009681 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA SMARCA4 http://www.ncbi.nlm.nih.gov/gene/6597 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009682 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA SOCS1 http://www.ncbi.nlm.nih.gov/gene/8651 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009683 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA SPI1 http://www.ncbi.nlm.nih.gov/gene/6688 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009684 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA TAB2 http://www.ncbi.nlm.nih.gov/gene/23118 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009685 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA TAF5L http://www.ncbi.nlm.nih.gov/gene/27097 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009686 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA TBC1D8B http://www.ncbi.nlm.nih.gov/gene/54885 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009687 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA TBCA http://www.ncbi.nlm.nih.gov/gene/6902 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009688 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA TCF12 http://www.ncbi.nlm.nih.gov/gene/6938 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009689 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA THSZ3 # - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009690 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA TLE4 http://www.ncbi.nlm.nih.gov/gene/7091 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009691 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA TM6SF1 http://www.ncbi.nlm.nih.gov/gene/53346 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009692 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA TP53INP1 http://www.ncbi.nlm.nih.gov/gene/94241 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009693 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA TRIP13 http://www.ncbi.nlm.nih.gov/gene/9319 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009694 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA TSGA14 http://www.ncbi.nlm.nih.gov/gene/95681 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009695 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA TWF1 http://www.ncbi.nlm.nih.gov/gene/5756 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009696 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA UBQLN1 http://www.ncbi.nlm.nih.gov/gene/29979 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009697 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA UPF2 http://www.ncbi.nlm.nih.gov/gene/26019 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009698 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA VPS18 http://www.ncbi.nlm.nih.gov/gene/57617 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009699 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA WEE1 http://www.ncbi.nlm.nih.gov/gene/7465 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009700 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA WHSC1L1 http://www.ncbi.nlm.nih.gov/gene/54904 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009701 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA WWC1 http://www.ncbi.nlm.nih.gov/gene/23286 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009702 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA XAF1 http://www.ncbi.nlm.nih.gov/gene/54739 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009703 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA ZIC3 http://www.ncbi.nlm.nih.gov/gene/7547 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009704 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA ZKSCAN5 http://www.ncbi.nlm.nih.gov/gene/23660 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009705 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA ZNF254 http://www.ncbi.nlm.nih.gov/gene/9534 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009706 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA ZNF257 http://www.ncbi.nlm.nih.gov/gene/113835 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009707 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA ZNF273 http://www.ncbi.nlm.nih.gov/gene/10793 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009708 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA ZNF28 http://www.ncbi.nlm.nih.gov/gene/7576 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009709 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA ZNF493 http://www.ncbi.nlm.nih.gov/gene/284443 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009710 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA ZNF561 http://www.ncbi.nlm.nih.gov/gene/729648 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009711 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA ZNF611 http://www.ncbi.nlm.nih.gov/gene/81856 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009712 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA ZNF652 http://www.ncbi.nlm.nih.gov/gene/22834 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009713 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BC1/3 - Host mRNA ZNF83 http://www.ncbi.nlm.nih.gov/gene/55769 - PAR-CLIP. 22100165 Table S7 Recovery of published miR-155 3'UTR targets as targets of miR-K11 by PAR-CLIP. VHID00009714 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA ACTR10 http://www.ncbi.nlm.nih.gov/gene/55860 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009715 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA ATP6V1C1 http://www.ncbi.nlm.nih.gov/gene/528 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009716 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA ATP6V1G1 http://www.ncbi.nlm.nih.gov/gene/9550 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009717 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA AUH http://www.ncbi.nlm.nih.gov/gene/549 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009718 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA BMP2K http://www.ncbi.nlm.nih.gov/gene/55589 - PAR-CLIP. 22100165 Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009719 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA CCT2 http://www.ncbi.nlm.nih.gov/gene/10576 - PAR-CLIP. 22100165 Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009720 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA CD59 http://www.ncbi.nlm.nih.gov/gene/966 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009721 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA CDC42EP4 http://www.ncbi.nlm.nih.gov/gene/23580 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009722 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA CLCN5 http://www.ncbi.nlm.nih.gov/gene/1184 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009723 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA COX11 http://www.ncbi.nlm.nih.gov/gene/1353 - PAR-CLIP. 22100165 Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009724 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA DMTF1 http://www.ncbi.nlm.nih.gov/gene/9988 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009725 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA E2F2 http://www.ncbi.nlm.nih.gov/gene/1870 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009726 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA EHD1 http://www.ncbi.nlm.nih.gov/gene/10938 - PAR-CLIP. 22100165 Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009727 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA FEM1C http://www.ncbi.nlm.nih.gov/gene/56929 - PAR-CLIP. 22100165 Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009728 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA FOS http://www.ncbi.nlm.nih.gov/gene/2353 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009729 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA GALT http://www.ncbi.nlm.nih.gov/gene/2592 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009730 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA GPSM2 http://www.ncbi.nlm.nih.gov/gene/29899 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009731 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA HMGCS1 http://www.ncbi.nlm.nih.gov/gene/3157 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009732 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA IGSF11 http://www.ncbi.nlm.nih.gov/gene/152404 - PAR-CLIP. 22100165 Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009733 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA KBTBD2 http://www.ncbi.nlm.nih.gov/gene/25948 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009734 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA KIFC2 http://www.ncbi.nlm.nih.gov/gene/90990 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009735 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA KLHL8 http://www.ncbi.nlm.nih.gov/gene/57563 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009736 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA LIG4 http://www.ncbi.nlm.nih.gov/gene/3981 - PAR-CLIP. 22100165 Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009737 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA MAP3K7IP2 http://www.ncbi.nlm.nih.gov/gene/23118 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009738 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA MOCS2 http://www.ncbi.nlm.nih.gov/gene/4338 - PAR-CLIP. 22100165 Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009739 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA MYB http://www.ncbi.nlm.nih.gov/gene/4602 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009740 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA MYD88 http://www.ncbi.nlm.nih.gov/gene/4615 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009741 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA NARS http://www.ncbi.nlm.nih.gov/gene/4677 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009742 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA NDFIP1 http://www.ncbi.nlm.nih.gov/gene/80762 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009743 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA NFIA http://www.ncbi.nlm.nih.gov/gene/4774 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009744 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009745 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA NR1D2 http://www.ncbi.nlm.nih.gov/gene/9975 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009746 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA OSTM1 http://www.ncbi.nlm.nih.gov/gene/28962 - PAR-CLIP. 22100165 Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009747 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA PCDHB10 http://www.ncbi.nlm.nih.gov/gene/56126 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009748 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA PET112L http://www.ncbi.nlm.nih.gov/gene/5188 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009749 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA PICALM http://www.ncbi.nlm.nih.gov/gene/8301 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009750 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA PLEKHB2 http://www.ncbi.nlm.nih.gov/gene/55041 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009751 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA PNPT1 http://www.ncbi.nlm.nih.gov/gene/87178 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009752 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA PPIL2 http://www.ncbi.nlm.nih.gov/gene/23759 - PAR-CLIP. 22100165 Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009753 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA PSKH1 http://www.ncbi.nlm.nih.gov/gene/5681 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009754 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA PTPN11 http://www.ncbi.nlm.nih.gov/gene/344593 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009755 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA PTPRJ http://www.ncbi.nlm.nih.gov/gene/5795 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009756 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA RAPGEF2 http://www.ncbi.nlm.nih.gov/gene/9693 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009757 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA RFK http://www.ncbi.nlm.nih.gov/gene/55312 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009758 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA RGL1 http://www.ncbi.nlm.nih.gov/gene/23179 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009759 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA SMAD5 http://www.ncbi.nlm.nih.gov/gene/4090 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009760 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA SNRPN http://www.ncbi.nlm.nih.gov/gene/8926 - PAR-CLIP. 22100165 Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009761 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA STRN3 http://www.ncbi.nlm.nih.gov/gene/29966 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009762 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA TCF12 http://www.ncbi.nlm.nih.gov/gene/6938 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009763 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA TCF7L2 http://www.ncbi.nlm.nih.gov/gene/6934 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009764 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA TMEM33 http://www.ncbi.nlm.nih.gov/gene/55161 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009765 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA TPD52 http://www.ncbi.nlm.nih.gov/gene/7163 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009766 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA TRAM1 http://www.ncbi.nlm.nih.gov/gene/23471 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009767 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA TRIP13 http://www.ncbi.nlm.nih.gov/gene/9319 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009768 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA TRUB1 http://www.ncbi.nlm.nih.gov/gene/142940 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009769 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA TXNRD1 http://www.ncbi.nlm.nih.gov/gene/7296 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009770 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA UPF2 http://www.ncbi.nlm.nih.gov/gene/26019 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells.Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009771 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA VAMP3 http://www.ncbi.nlm.nih.gov/gene/9341 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009772 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA XPNPEP1 http://www.ncbi.nlm.nih.gov/gene/7511 - PAR-CLIP. 22100165 Table S10F Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009773 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 BJAB/miR-K11 cells - Host mRNA ZNF621 http://www.ncbi.nlm.nih.gov/gene/285268 - PAR-CLIP. 22100165 Table S10C Genes that contribute to the enrichments of PAR-CLIP targets of miR-K11 from BC-1 libraries in downregulated mRNAs in BJAB/miR-K11 cells. VHID00009774 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 Primary effusion lymphoma (PEL) cell lines - Host Protein FOS http://www.ncbi.nlm.nih.gov/gene/2353 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00009775 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 Primary effusion lymphoma (PEL) cell lines - Host Protein LDOC1 http://www.ncbi.nlm.nih.gov/gene/23641 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00009776 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 Primary effusion lymphoma (PEL) cell lines - Host Protein MAF http://www.ncbi.nlm.nih.gov/gene/4094 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00009777 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 Primary effusion lymphoma (PEL) cell lines - Host Protein MAP3K10 http://www.ncbi.nlm.nih.gov/gene/4294 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00009778 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 Primary effusion lymphoma (PEL) cell lines - Host Protein MATR3 http://www.ncbi.nlm.nih.gov/gene/9782 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00009779 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 Primary effusion lymphoma (PEL) cell lines - Host Protein TM6SF1 http://www.ncbi.nlm.nih.gov/gene/53346 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00009780 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host Protein BACH1 http://www.ncbi.nlm.nih.gov/gene/83990 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00009781 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host Protein BACH1 http://www.ncbi.nlm.nih.gov/gene/83990 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00009782 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host Protein CEBPB(C/EBPbeta) http://www.ncbi.nlm.nih.gov/gene/1051 - Luciferase assays,qRT-PCR. 21813606 Subsequent quantitative PCR analyses of these splenic B cells revealed that C/EBPbeta, a transcriptional regulator of interleukin-6 that is linked to B-cell lymphoproliferative disorders, is downregulated when either miR-K12-11 or miR-155 is ectopically expressed. VHID00009783 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host Protein CSNK1A1 http://www.ncbi.nlm.nih.gov/gene/1452 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00009784 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host Protein DUSP1 http://www.ncbi.nlm.nih.gov/gene/1843 Upregulation Luciferase reporter assays. 23097457 Finally, proof-of-principle experiments revealed that pharmacologic upregulation of DUSP1 inhibits the induction of promigratory factors and cell invasiveness duringde novoKSHV infection. These data reveal an indirect role for miR-K12-11 in the regulation of DUSP1 and downstream pathogenesis.miR-K12-11 induces endothelial cell invasion through indirect transcriptional repression of DUSP1. VHID00009785 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host Protein IKBKE http://www.ncbi.nlm.nih.gov/gene/9641 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00009786 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host Protein IKK? http://www.ncbi.nlm.nih.gov/gene/9641 Downregulation In vitro expression reporter assay, qRT-PCR, Plaque assay. 21221132 Ectopic expression of miR-K12-11 resulted in decreased IKK expression, while inhibition of miR-K12-11 was found to restore IKK expression in KSHV-infected cells. VHID00009787 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host Protein MAF http://www.ncbi.nlm.nih.gov/gene/4094 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00009788 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host Protein MAF1 http://www.ncbi.nlm.nih.gov/gene/84232 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00009789 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host Protein SLC7A11(xCT) http://www.ncbi.nlm.nih.gov/gene/23657 Upregulation Luciferase reporter assays, Immunofluorescence assays. 23097457 We found that ERK-dependent latent viral gene expression, the induction of promigratory factors, and cell invasiveness followingde novoinfection of primary human endothelial cells are in part dependent on KSHV suppression of DUSP1 expression duringde novoinfection.KSHV-encoded miR-K12-11 upregulates the expression of xCT (an amino acid transporter and KSHV fusion/entry receptor), and existing data indicate a role for xCT in the regulation of 14-3-3 , a transcriptional repressor of DUSP1. VHID00009790 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host Protein THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00009791 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host Protein WEE1 http://www.ncbi.nlm.nih.gov/gene/7465 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00009792 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host Protein XAF1(BIRC4BP) http://www.ncbi.nlm.nih.gov/gene/54739 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009793 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA AGTRAP http://www.ncbi.nlm.nih.gov/gene/57085 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009794 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA BACH1 http://www.ncbi.nlm.nih.gov/gene/571 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009795 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA BACH1 http://www.ncbi.nlm.nih.gov/gene/571 Downregulation - 19158788 An extreme example of this is seen with the KSHV miRNA miR-K12-11, which shares an identical seed region with the cellular miRNA miR-155 and appears to downregulate an identical, or nearly identical, set of target mRNAs. The most fully characterized of these is the mRNA encoding BACH1, which contains several targets for both miR-K12-11 and miR-155 in its 3'UTR. . VHID00009796 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA BCL2L11 http://www.ncbi.nlm.nih.gov/gene/10018 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009797 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA CEBPB http://www.ncbi.nlm.nih.gov/gene/1051 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009798 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA FOS http://www.ncbi.nlm.nih.gov/gene/2353 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009799 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA HIVEP2 http://www.ncbi.nlm.nih.gov/gene/3097 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009800 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA IKBKE http://www.ncbi.nlm.nih.gov/gene/9641 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009801 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA LDOC1 http://www.ncbi.nlm.nih.gov/gene/23641 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009802 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA MAF http://www.ncbi.nlm.nih.gov/gene/4094 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009803 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA MAP3K10 http://www.ncbi.nlm.nih.gov/gene/4294 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009804 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA PIK3CA http://www.ncbi.nlm.nih.gov/gene/5290 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009805 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA RFK http://www.ncbi.nlm.nih.gov/gene/55312 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009806 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA RPS6KA3 http://www.ncbi.nlm.nih.gov/gene/6197 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009807 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA SAMHD1 http://www.ncbi.nlm.nih.gov/gene/25939 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009808 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA SLA http://www.ncbi.nlm.nih.gov/gene/6503 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009809 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA SMAD5 http://www.ncbi.nlm.nih.gov/gene/4090 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009810 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VHID00009811 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA TM6SF1 http://www.ncbi.nlm.nih.gov/gene/53346 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009812 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA TWF1 http://www.ncbi.nlm.nih.gov/gene/5756 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009813 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA XAF1(BIRC4BP) http://www.ncbi.nlm.nih.gov/gene/54739 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009814 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host mRNA ZCCHC5(MART3) http://www.ncbi.nlm.nih.gov/gene/203430 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009815 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 293 Cells - Host Protein THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 Downregulation Luciferase de-repression assay. 17500590 We performed luciferase de-repression assays by co-transfection of the THBS1 3'UTR reporter and 2'OMe RNAs specific to individual KSHV miRNAs. Our results demonstrate that THBS1 is targeted by multiple KSHV miRNAs; in particular, miR-K12-1, miR-K12-3-3p, miR-K12-6-3p, and miR-K12-11 lead to strong de-repression of the reporter. VHID00009816 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 HeLa cells - Host mRNA BACH1 http://www.ncbi.nlm.nih.gov/gene/571 Downregulation Western Blot analyses, pNL-SIN-CMV-AcGFP, gene set enrichment analysis, Dual luciferase assays, quantitative RT-PCR analysis. 18075594 We show that expression of physiological levels of miR-K12-11 or miR-155 results in the downregulation of an extensive set of common mRNA target.For example, one predicted target for miR-155, BACH1, was only modestly downregulated at the mRNA level, but repression of the indicator bearing the BACH1 3oUTR was k85% for both miR-155 and miR-K12-11. To show that equivalent downregulation by miR-K12 11 and miR-155 also occurs with endogenous proteins, we performed Western Blot analyses for two targets, BACH1 and FOS. VHID00009817 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 HeLa cells - Host mRNA FOS http://www.ncbi.nlm.nih.gov/gene/2353 Downregulation Western Blot analyses, pNL-SIN-CMV-AcGFP, gene set enrichment analysis, Dual luciferase assays, quantitative RT-PCR analysis. 18075594 We show that expression of physiological levels of miR-K12-11 or miR-155 results in the downregulation of an extensive set of common mRNA target.For example, one predicted target for miR-155, BACH1, was only modestly downregulated at the mRNA level, but repression of the indicator bearing the BACH1 3oUTR was k85% for both miR-155 and miR-K12-11. To show that equivalent downregulation by miR-K12 11 and miR-155 also occurs with endogenous proteins, we performed Western Blot analyses for two targets, BACH1 and FOS. VHID00009818 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 Lymphatic endothelial cells - Host Protein MAF http://www.ncbi.nlm.nih.gov/gene/4094 Downregulation qPCR and qRT-PCR, Western blotting, Luciferase reporter assays. 20080955 Site-directed mutagenesis of KSHV miRNA predicted target sites in the MAF 3'UTR abolished silencing, confirming that miR-K12-1, miR-K12-6-5p, and miR-K12-11 regulate MAF by interacting with the 3'UTR. VHID00009819 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 Lymphocytes - Host Protein BACH1 http://www.ncbi.nlm.nih.gov/gene/83990 - Reporter Assay,Luciferase Reporter,Western blotting. 21152115 KSHV miR-K12-11 shares sequence identity with cellular miR-155 in the seed region, which confers much of the target specificity, and has the potential to regulate multiple transcripts, in particular BACH-1(BTB and CNC homology 1, a transcription factor), via the same binding sites utilized by the host miR-155. VHID00009820 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 Lymphocytes - Host Protein MAF http://www.ncbi.nlm.nih.gov/gene/4094 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 miR-K12-1,-6, and -11 decrease of MAF(musculoaponeurotic fibrosarcoma oncogene homolog), K12-4-5p targeting retinoblastoma(Rb)-like protein 2(Rbl2). VHID00009821 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 Lymphocytes - Host Protein THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 KSHV miR-K12-1, miR-K12-3-3p, miR-K12-6-3p, and miR-K12-11 reduce the expression of THBS1(thrombospondin 1) by interaction with the THBS1 4' UTR. VHID00009822 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC3 - Host mRNA CDKN1A/p21 http://www.ncbi.nlm.nih.gov/gene/1026 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009823 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC3 - Host mRNA NHP2L1 http://www.ncbi.nlm.nih.gov/gene/4809 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009824 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BCBL1 - Host mRNA CDKN1A/p21 http://www.ncbi.nlm.nih.gov/gene/1026 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009825 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA ANP32A http://www.ncbi.nlm.nih.gov/gene/8125 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009826 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA C1orf144 http://www.ncbi.nlm.nih.gov/gene/26099 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009827 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA CS http://www.ncbi.nlm.nih.gov/gene/1431 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009828 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA LPIN1 http://www.ncbi.nlm.nih.gov/gene/23175 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009829 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA LYRM5 http://www.ncbi.nlm.nih.gov/gene/144363 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009830 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA NCOR1 http://www.ncbi.nlm.nih.gov/gene/9611 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009831 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA PPP1CB http://www.ncbi.nlm.nih.gov/gene/245711 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009832 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA SP100 http://www.ncbi.nlm.nih.gov/gene/6672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009833 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA TMEM181 http://www.ncbi.nlm.nih.gov/gene/57583 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009834 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA VPS39 http://www.ncbi.nlm.nih.gov/gene/23339 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009835 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA ABL2 http://www.ncbi.nlm.nih.gov/gene/27 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009836 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA ADCK1 http://www.ncbi.nlm.nih.gov/gene/57143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009837 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA ALG1 http://www.ncbi.nlm.nih.gov/gene/56052 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009838 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA ANP32A http://www.ncbi.nlm.nih.gov/gene/8125 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009839 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA APOBEC3C http://www.ncbi.nlm.nih.gov/gene/27350 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009840 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA ATP9A http://www.ncbi.nlm.nih.gov/gene/10079 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009841 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA ATXN7L1 http://www.ncbi.nlm.nih.gov/gene/222255 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009842 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA BAG5 http://www.ncbi.nlm.nih.gov/gene/9529 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009843 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA C20orf117 http://www.ncbi.nlm.nih.gov/gene/140710 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009844 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA C9orf91 http://www.ncbi.nlm.nih.gov/gene/203197 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009845 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA CCDC21 http://www.ncbi.nlm.nih.gov/gene/64793 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009846 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA CLPTM1L http://www.ncbi.nlm.nih.gov/gene/81037 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009847 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA CS http://www.ncbi.nlm.nih.gov/gene/1431 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009848 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA DCAKD http://www.ncbi.nlm.nih.gov/gene/79877 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009849 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA DCBLD2 http://www.ncbi.nlm.nih.gov/gene/131566 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009850 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA DHX36 http://www.ncbi.nlm.nih.gov/gene/170506 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009851 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA ENPP4 http://www.ncbi.nlm.nih.gov/gene/22875 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009852 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA FRK http://www.ncbi.nlm.nih.gov/gene/2444 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009853 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA GCNT2 http://www.ncbi.nlm.nih.gov/gene/2651 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009854 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA GNPNAT1 http://www.ncbi.nlm.nih.gov/gene/64841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009855 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA HNF4G http://www.ncbi.nlm.nih.gov/gene/3174 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009856 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA IKZF3 http://www.ncbi.nlm.nih.gov/gene/22806 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009857 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA KIAA1147 http://www.ncbi.nlm.nih.gov/gene/57189 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009858 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA LYRM5 http://www.ncbi.nlm.nih.gov/gene/144363 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009859 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA MUC13 http://www.ncbi.nlm.nih.gov/gene/56667 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009860 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA MYO1D http://www.ncbi.nlm.nih.gov/gene/4642 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009861 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA NCOR1 http://www.ncbi.nlm.nih.gov/gene/9611 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009862 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA PDE4D http://www.ncbi.nlm.nih.gov/gene/5144 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009863 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA PPP1CB http://www.ncbi.nlm.nih.gov/gene/245711 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009864 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA PRDM15 http://www.ncbi.nlm.nih.gov/gene/63977 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009865 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA PRKAR1A http://www.ncbi.nlm.nih.gov/gene/5573 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009866 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA PYGO2 http://www.ncbi.nlm.nih.gov/gene/90780 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009867 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA RASA2 http://www.ncbi.nlm.nih.gov/gene/5922 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009868 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA REEP5 http://www.ncbi.nlm.nih.gov/gene/7905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009869 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA SENP2 http://www.ncbi.nlm.nih.gov/gene/59343 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009870 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA SIKE1 http://www.ncbi.nlm.nih.gov/gene/80143 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009871 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA SLC30A7 http://www.ncbi.nlm.nih.gov/gene/148867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009872 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA SLC35D1 http://www.ncbi.nlm.nih.gov/gene/23169 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009873 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA SMAD4 http://www.ncbi.nlm.nih.gov/gene/4089 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009874 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA SP100 http://www.ncbi.nlm.nih.gov/gene/6672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009875 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA STRADA http://www.ncbi.nlm.nih.gov/gene/92335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009876 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA TIMM17A http://www.ncbi.nlm.nih.gov/gene/10440 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009877 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA TMEM126B http://www.ncbi.nlm.nih.gov/gene/55863 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009878 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA TMEM189 http://www.ncbi.nlm.nih.gov/gene/387522 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009879 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA TMPO http://www.ncbi.nlm.nih.gov/gene/7112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009880 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA TOR2A http://www.ncbi.nlm.nih.gov/gene/27433 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009881 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA TRIM14 http://www.ncbi.nlm.nih.gov/gene/9830 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009882 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA TTC31 http://www.ncbi.nlm.nih.gov/gene/64427 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009883 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA VPS39 http://www.ncbi.nlm.nih.gov/gene/23339 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009884 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA WHSC1L1 http://www.ncbi.nlm.nih.gov/gene/54904 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009885 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA WWTR1 http://www.ncbi.nlm.nih.gov/gene/25937 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009886 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA YBX1 http://www.ncbi.nlm.nih.gov/gene/4904 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009887 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA ZDHHC7 http://www.ncbi.nlm.nih.gov/gene/55625 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009888 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA ZFAND5 http://www.ncbi.nlm.nih.gov/gene/732229 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009889 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA ZMAT2 http://www.ncbi.nlm.nih.gov/gene/153527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009890 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-3 - Host mRNA ZNF12 http://www.ncbi.nlm.nih.gov/gene/7559 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009891 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA ARID1A http://www.ncbi.nlm.nih.gov/gene/8289 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009892 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA ASXL1 http://www.ncbi.nlm.nih.gov/gene/171023 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009893 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA ATF7 http://www.ncbi.nlm.nih.gov/gene/11016 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009894 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA BAZ1B http://www.ncbi.nlm.nih.gov/gene/9031 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009895 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA BIRC2 http://www.ncbi.nlm.nih.gov/gene/329 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009896 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA BSN http://www.ncbi.nlm.nih.gov/gene/8927 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009897 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA C18orf25 http://www.ncbi.nlm.nih.gov/gene/147339 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009898 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA C19orf22 http://www.ncbi.nlm.nih.gov/gene/91300 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009899 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA C5orf15 http://www.ncbi.nlm.nih.gov/gene/56951 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009900 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA C5orf41 http://www.ncbi.nlm.nih.gov/gene/153222 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009901 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA C9orf91 http://www.ncbi.nlm.nih.gov/gene/203197 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009902 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA CDADC1 http://www.ncbi.nlm.nih.gov/gene/81602 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009903 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA CDKN1A http://www.ncbi.nlm.nih.gov/gene/1026 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009904 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA CLCN5 http://www.ncbi.nlm.nih.gov/gene/1184 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009905 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA CPEB4 http://www.ncbi.nlm.nih.gov/gene/80315 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009906 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA DCAF7 http://www.ncbi.nlm.nih.gov/gene/10238 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009907 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA DCP1A http://www.ncbi.nlm.nih.gov/gene/55802 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009908 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA EXOSC3 http://www.ncbi.nlm.nih.gov/gene/51010 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009909 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA FBN1 http://www.ncbi.nlm.nih.gov/gene/2200 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009910 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA FLOT2 http://www.ncbi.nlm.nih.gov/gene/2319 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009911 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA FRS2 http://www.ncbi.nlm.nih.gov/gene/10818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009912 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA HNRNPAB http://www.ncbi.nlm.nih.gov/gene/3182 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009913 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA IGF1R http://www.ncbi.nlm.nih.gov/gene/3480 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009914 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA IGF2BP3 http://www.ncbi.nlm.nih.gov/gene/10643 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009915 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA IGF2R http://www.ncbi.nlm.nih.gov/gene/3482 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009916 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA KDM2A http://www.ncbi.nlm.nih.gov/gene/22992 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009917 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA KIAA0831 http://www.ncbi.nlm.nih.gov/gene/22863 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009918 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA LASS6 http://www.ncbi.nlm.nih.gov/gene/253782 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009919 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA MAFG http://www.ncbi.nlm.nih.gov/gene/4097 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009920 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA MAP7D1 http://www.ncbi.nlm.nih.gov/gene/55700 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009921 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA MINK1 http://www.ncbi.nlm.nih.gov/gene/50488 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009922 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA MLL http://www.ncbi.nlm.nih.gov/gene/4297 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009923 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA MTCH2 http://www.ncbi.nlm.nih.gov/gene/23788 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009924 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA NAB1 http://www.ncbi.nlm.nih.gov/gene/4664 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009925 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA NONO http://www.ncbi.nlm.nih.gov/gene/4841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009926 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA OAS2 http://www.ncbi.nlm.nih.gov/gene/4939 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009927 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA PHLDA3 http://www.ncbi.nlm.nih.gov/gene/23612 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009928 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA PISD http://www.ncbi.nlm.nih.gov/gene/23761 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009929 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA PNPLA6 http://www.ncbi.nlm.nih.gov/gene/10908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009930 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA REST http://www.ncbi.nlm.nih.gov/gene/5978 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009931 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA RQCD1 http://www.ncbi.nlm.nih.gov/gene/9125 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009932 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA SDHAF1 http://www.ncbi.nlm.nih.gov/gene/644096 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009933 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA SETD5 http://www.ncbi.nlm.nih.gov/gene/55209 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009934 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA SOX12 http://www.ncbi.nlm.nih.gov/gene/6666 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009935 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA TNKS http://www.ncbi.nlm.nih.gov/gene/8658 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009936 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA WDR26 http://www.ncbi.nlm.nih.gov/gene/80232 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009937 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA WEE1 http://www.ncbi.nlm.nih.gov/gene/7465 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009938 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA WHSC1 http://www.ncbi.nlm.nih.gov/gene/7468 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009939 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA ZBTB34 http://www.ncbi.nlm.nih.gov/gene/403341 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009940 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA ZNF275 http://www.ncbi.nlm.nih.gov/gene/10838 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009941 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA ZNF451 http://www.ncbi.nlm.nih.gov/gene/26036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009942 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-12(miR-K12*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004987 BC-1 - Host mRNA ZSWIM4 http://www.ncbi.nlm.nih.gov/gene/65249 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009943 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-2(K2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002476 BC3 - Host mRNA BCLAF1 http://www.ncbi.nlm.nih.gov/gene/731605 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009944 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC3 - Host mRNA CASP3 http://www.ncbi.nlm.nih.gov/gene/836 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009945 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC3 - Host mRNA EXOC6 http://www.ncbi.nlm.nih.gov/gene/54536 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009946 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC3 - Host mRNA LRRC8D http://www.ncbi.nlm.nih.gov/gene/55144 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009947 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC3 - Host mRNA NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009948 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC3 - Host mRNA NHP2L1 http://www.ncbi.nlm.nih.gov/gene/4809 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009949 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BCBL1 - Host mRNA CASP3 http://www.ncbi.nlm.nih.gov/gene/836 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009950 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BCBL1 - Host mRNA EXOC6 http://www.ncbi.nlm.nih.gov/gene/54536 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009951 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BCBL1 - Host mRNA LRRC8D http://www.ncbi.nlm.nih.gov/gene/55144 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009952 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BCBL1 - Host mRNA NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009953 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BCBL1 - Host mRNA NHP2L1 http://www.ncbi.nlm.nih.gov/gene/4809 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009954 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BCBL1 - Host mRNA SLA http://www.ncbi.nlm.nih.gov/gene/6503 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009955 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BCBL1 - Host mRNA THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009956 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(K3*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002194 BCBL1 - Host mRNA THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00009957 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(kshv-miR-K12-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 - - Host Protein NHP2L1 http://www.ncbi.nlm.nih.gov/gene/4809 - 3'UTR dual-luciferase assay. 20413099 We identified a high confidence interaction site for kshv-miR-K12-4-3p in the coding sequence of GEMIN8 and for kshv-miR-K12-3 in the coding sequence of NHP2L1. VHID00009958 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(kshv-miR-K12-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 - - Host Protein NHP2L1 http://www.ncbi.nlm.nih.gov/gene/4809 Downregulation 3'UTR dual-luciferase assay. 20413099 We identified a high confidence interaction site for kshv-miR-K12-4-3p in the coding sequence of GEMIN8 and for kshv-miR-K12-3 in the coding sequence of NHP2L1. VHID00009959 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K12-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 - - Host Protein CEBPB http://www.ncbi.nlm.nih.gov/gene/1051 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00009960 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K12-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 - - Host Protein GEMIN8 http://www.ncbi.nlm.nih.gov/gene/54960 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00009961 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K12-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 - - Host Protein LIP http://www.ncbi.nlm.nih.gov/gene/23049 Downregulation KSHV miRNA target identification, ELISA, TLR inhibition assays, immunoblot analyses, Immunoblots, RT-PCR. 20052801 Subsequent immunoblot analyses revealed that miR-K12-3 and miR-K12-7 preferentially reduce expression of C/EBPbeta p20(LIP), an isoform of C/EBPbeta known to function as a negative transcription regulator. VHID00009962 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K12-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 - - Host Protein LRRC8D http://www.ncbi.nlm.nih.gov/gene/55144 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00009963 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K12-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 - - Host Protein LRRC8D http://www.ncbi.nlm.nih.gov/gene/55144 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00009964 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K12-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 - - Host Protein NFIB http://www.ncbi.nlm.nih.gov/gene/4781 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00009965 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K12-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 - - Host Protein NFIB http://www.ncbi.nlm.nih.gov/gene/4781 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00009966 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K12-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 - - Host Protein NHP2L1 http://www.ncbi.nlm.nih.gov/gene/4809 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00009967 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K12-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 - - Host mRNA CASP3 http://www.ncbi.nlm.nih.gov/gene/836 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009968 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K12-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 - - Host mRNA CEBPE(C/EBP) http://www.ncbi.nlm.nih.gov/gene/1053 - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VHID00009969 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K12-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 - - Host mRNA NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00009970 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K12-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 DG-75-K10/12 cells - Host Protein CASP3 http://www.ncbi.nlm.nih.gov/gene/836 Downregulation Northern blot analysis, Real-time PCR, Luciferase assays, Small RNA cloning and sequencing, Western blot analysis. 22174674 We found that three KSHV miRNAs, miR-K12-1, 3 and 4-3p, were responsible for the targeting of Casp3.Potential cellular targets that were significantly down-regulated upon KSHV miRNAs expression were identified by microarray profiling. VHID00009971 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K12-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 HEK293 cells - Host Protein CASP3 http://www.ncbi.nlm.nih.gov/gene/836 - Luciferase assays,quantitative PCR and western blotting. 22174674 we validated by luciferase reporter assays, quantitative PCR and western blotting caspase 3 (Casp3), a critical factor for the control of apoptosis. Using site-directed mutagenesis, we found that three KSHV miRNAs, miR-K12-1, 3 and 4-3p, were responsible for the targeting of Casp3. . VHID00009972 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K12-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 Lymphocytes - Host Protein LRRC8D http://www.ncbi.nlm.nih.gov/gene/55144 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 miR-K12-3 reduction of LRRC8D , a leucin-rich type III transmembrane protein involved in proliferation and activation of lymphocytes, NHP2L1 , and a transcription factor NFIB, . VHID00009973 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K12-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 Lymphocytes - Host Protein NFIB http://www.ncbi.nlm.nih.gov/gene/4781 Upregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 miR-K12-3 reduction of LRRC8D , a leucin-rich type III transmembrane protein involved in proliferation and activation of lymphocytes, NHP2L4 , and a transcription factor NFIB,. VHID00009974 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K12-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 Lymphocytes - Host Protein NHP2L1 http://www.ncbi.nlm.nih.gov/gene/4809 Upregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 miR-K12-3 reduction of LRRC8D , a leucin-rich type III transmembrane protein involved in proliferation and activation of lymphocytes, NHP2L3 , and a transcription factor NFIB,. VHID00009975 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 - - Host Protein LRRC8D http://www.ncbi.nlm.nih.gov/gene/55144 - Modeling of possible hybrids, derepression assays by using a 20-O-methyl RNA complementary. 20413099 Modeling of possible hybrids between the LRRC8D 3'UTR and the KSHV-encoded miRNAs suggested a strong interaction of the 3'UTR with kshv-miR-K12-3. VHID00009976 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA AKAP11 http://www.ncbi.nlm.nih.gov/gene/11215 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009977 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA ATRX http://www.ncbi.nlm.nih.gov/gene/546 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009978 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA BLCAP http://www.ncbi.nlm.nih.gov/gene/10904 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009979 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA BNIP2 http://www.ncbi.nlm.nih.gov/gene/663 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009980 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA BRCA1 http://www.ncbi.nlm.nih.gov/gene/672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009981 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA BRWD1 http://www.ncbi.nlm.nih.gov/gene/54014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009982 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA C10orf46 http://www.ncbi.nlm.nih.gov/gene/143384 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009983 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA C12orf76 http://www.ncbi.nlm.nih.gov/gene/400073 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009984 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA C18orf54 http://www.ncbi.nlm.nih.gov/gene/162681 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009985 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA C20orf112 http://www.ncbi.nlm.nih.gov/gene/140688 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009986 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA C2orf69 http://www.ncbi.nlm.nih.gov/gene/205327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009987 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA C3orf52 http://www.ncbi.nlm.nih.gov/gene/79669 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009988 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA C9orf5 http://www.ncbi.nlm.nih.gov/gene/23731 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009989 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA CAPRIN1 http://www.ncbi.nlm.nih.gov/gene/4076 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009990 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA CARD8 http://www.ncbi.nlm.nih.gov/gene/22900 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009991 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA CASP3 http://www.ncbi.nlm.nih.gov/gene/836 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009992 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA CASP7 http://www.ncbi.nlm.nih.gov/gene/840 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009993 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA CCDC82 http://www.ncbi.nlm.nih.gov/gene/79780 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009994 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA CCNL1 http://www.ncbi.nlm.nih.gov/gene/57018 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009995 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA CLDN12 http://www.ncbi.nlm.nih.gov/gene/9069 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009996 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA CNOT4 http://www.ncbi.nlm.nih.gov/gene/4850 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009997 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA CSNK1G3 http://www.ncbi.nlm.nih.gov/gene/1456 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009998 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA CTCF http://www.ncbi.nlm.nih.gov/gene/10664 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00009999 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA DDX47 http://www.ncbi.nlm.nih.gov/gene/51202 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010000 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA EXOC6 http://www.ncbi.nlm.nih.gov/gene/54536 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010001 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA FOXP2 http://www.ncbi.nlm.nih.gov/gene/93986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010002 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA GATAD2B http://www.ncbi.nlm.nih.gov/gene/57459 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010003 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA GTSE1 http://www.ncbi.nlm.nih.gov/gene/51512 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010004 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA HECTD3 http://www.ncbi.nlm.nih.gov/gene/79654 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010005 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA HIST1H3D http://www.ncbi.nlm.nih.gov/gene/8356 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010006 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA HMGB2 http://www.ncbi.nlm.nih.gov/gene/3148 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010007 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA INO80 http://www.ncbi.nlm.nih.gov/gene/54617 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010008 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA JARID2 http://www.ncbi.nlm.nih.gov/gene/3720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010009 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA KDM6A http://www.ncbi.nlm.nih.gov/gene/7403 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010010 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA KIAA1467 http://www.ncbi.nlm.nih.gov/gene/57613 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010011 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA KLHDC5 http://www.ncbi.nlm.nih.gov/gene/57542 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010012 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA LIN54 http://www.ncbi.nlm.nih.gov/gene/132660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010013 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA LMBR1 http://www.ncbi.nlm.nih.gov/gene/64327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010014 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA MAK16 http://www.ncbi.nlm.nih.gov/gene/84549 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010015 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA MED4 http://www.ncbi.nlm.nih.gov/gene/29079 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010016 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA NGLY1 http://www.ncbi.nlm.nih.gov/gene/55768 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010017 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA NUAK2 http://www.ncbi.nlm.nih.gov/gene/81788 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010018 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA NUCKS1 http://www.ncbi.nlm.nih.gov/gene/64710 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010019 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA NUFIP2 http://www.ncbi.nlm.nih.gov/gene/57532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010020 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA PARD6B http://www.ncbi.nlm.nih.gov/gene/84612 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010021 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA PI4KB http://www.ncbi.nlm.nih.gov/gene/5298 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010022 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA PKIA http://www.ncbi.nlm.nih.gov/gene/5569 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010023 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA PPM1K http://www.ncbi.nlm.nih.gov/gene/152926 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010024 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA PPP1R12A http://www.ncbi.nlm.nih.gov/gene/4659 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010025 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA QSER1 http://www.ncbi.nlm.nih.gov/gene/79832 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010026 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA RAB4A http://www.ncbi.nlm.nih.gov/gene/5867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010027 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA RAD51AP1 http://www.ncbi.nlm.nih.gov/gene/10635 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010028 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA RCOR1 http://www.ncbi.nlm.nih.gov/gene/23186 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010029 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA RNF168 http://www.ncbi.nlm.nih.gov/gene/165918 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010030 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA RPL31 http://www.ncbi.nlm.nih.gov/gene/653773 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010031 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA RPRD1A http://www.ncbi.nlm.nih.gov/gene/55197 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010032 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA SACM1L http://www.ncbi.nlm.nih.gov/gene/22908 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010033 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA SEC14L1 http://www.ncbi.nlm.nih.gov/gene/6397 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010034 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA SEC24C http://www.ncbi.nlm.nih.gov/gene/9632 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010035 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA SERINC1 http://www.ncbi.nlm.nih.gov/gene/57515 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010036 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA SESN2 http://www.ncbi.nlm.nih.gov/gene/83667 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010037 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA SETD1B http://www.ncbi.nlm.nih.gov/gene/23067 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010038 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA SLC25A36 http://www.ncbi.nlm.nih.gov/gene/55186 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010039 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA SLC37A3 http://www.ncbi.nlm.nih.gov/gene/84255 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010040 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA SLC38A2 http://www.ncbi.nlm.nih.gov/gene/54407 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010041 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA SLC7A1 http://www.ncbi.nlm.nih.gov/gene/6541 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010042 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA STAT5B http://www.ncbi.nlm.nih.gov/gene/6777 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010043 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA STBD1 http://www.ncbi.nlm.nih.gov/gene/8987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010044 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA STX12 http://www.ncbi.nlm.nih.gov/gene/23673 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010045 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA STX6 http://www.ncbi.nlm.nih.gov/gene/10228 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010046 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA TBL1XR1 http://www.ncbi.nlm.nih.gov/gene/79718 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010047 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA TBR1 http://www.ncbi.nlm.nih.gov/gene/10716 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010048 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA THOC7 http://www.ncbi.nlm.nih.gov/gene/80145 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010049 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA TMEM50A http://www.ncbi.nlm.nih.gov/gene/23585 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010050 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA TNFAIP3 http://www.ncbi.nlm.nih.gov/gene/7128 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010051 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA TNPO1 http://www.ncbi.nlm.nih.gov/gene/3842 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010052 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA TNRC6A http://www.ncbi.nlm.nih.gov/gene/27327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010053 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA TNRC6B http://www.ncbi.nlm.nih.gov/gene/23112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010054 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA TRIB1 http://www.ncbi.nlm.nih.gov/gene/10221 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010055 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA TSNAX http://www.ncbi.nlm.nih.gov/gene/7257 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010056 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA TUSC2 http://www.ncbi.nlm.nih.gov/gene/11334 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010057 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA UBE2R2 http://www.ncbi.nlm.nih.gov/gene/54926 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010058 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA VKORC1L1 http://www.ncbi.nlm.nih.gov/gene/154807 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010059 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA VRK3 http://www.ncbi.nlm.nih.gov/gene/51231 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010060 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA WBP2 http://www.ncbi.nlm.nih.gov/gene/23558 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010061 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA WNK1 http://www.ncbi.nlm.nih.gov/gene/65125 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010062 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA WRB http://www.ncbi.nlm.nih.gov/gene/7485 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010063 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA YOD1 http://www.ncbi.nlm.nih.gov/gene/55432 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010064 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA ZNF473 http://www.ncbi.nlm.nih.gov/gene/25888 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010065 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA ZNF550 http://www.ncbi.nlm.nih.gov/gene/162972 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010066 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA ZNF588 http://www.ncbi.nlm.nih.gov/gene/51427 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010067 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-1 - Host mRNA ZNF680 http://www.ncbi.nlm.nih.gov/gene/340252 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010068 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA ADRBK1 http://www.ncbi.nlm.nih.gov/gene/156 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010069 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA AGK http://www.ncbi.nlm.nih.gov/gene/55750 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010070 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA ALG3 http://www.ncbi.nlm.nih.gov/gene/10195 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010071 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA ANKRD52 http://www.ncbi.nlm.nih.gov/gene/283373 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010072 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA BLCAP http://www.ncbi.nlm.nih.gov/gene/10904 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010073 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA BRCA1 http://www.ncbi.nlm.nih.gov/gene/672 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010074 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA BRWD1 http://www.ncbi.nlm.nih.gov/gene/54014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010075 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA C18orf55 http://www.ncbi.nlm.nih.gov/gene/29090 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010076 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA C20orf117 http://www.ncbi.nlm.nih.gov/gene/140710 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010077 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA C21orf45 http://www.ncbi.nlm.nih.gov/gene/54069 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010078 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA C2orf69 http://www.ncbi.nlm.nih.gov/gene/205327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010079 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA C9orf5 http://www.ncbi.nlm.nih.gov/gene/23731 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010080 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA CAPRIN1 http://www.ncbi.nlm.nih.gov/gene/4076 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010081 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA CASP7 http://www.ncbi.nlm.nih.gov/gene/840 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010082 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA CBFA2T2 http://www.ncbi.nlm.nih.gov/gene/9139 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010083 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA CCNL1 http://www.ncbi.nlm.nih.gov/gene/57018 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010084 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA CNOT8 http://www.ncbi.nlm.nih.gov/gene/9337 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010085 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA COBL http://www.ncbi.nlm.nih.gov/gene/23242 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010086 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA CPEB4 http://www.ncbi.nlm.nih.gov/gene/80315 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010087 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA CPOX http://www.ncbi.nlm.nih.gov/gene/1371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010088 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA CRLF3 http://www.ncbi.nlm.nih.gov/gene/51379 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010089 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA CTSC http://www.ncbi.nlm.nih.gov/gene/1075 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010090 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA DBF4 http://www.ncbi.nlm.nih.gov/gene/10926 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010091 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA DEF8 http://www.ncbi.nlm.nih.gov/gene/54849 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010092 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA DIP2B http://www.ncbi.nlm.nih.gov/gene/57609 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010093 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA DIS3 http://www.ncbi.nlm.nih.gov/gene/22894 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010094 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA FBXO32 http://www.ncbi.nlm.nih.gov/gene/114907 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010095 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA FNIP1 http://www.ncbi.nlm.nih.gov/gene/96459 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010096 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA FOXP2 http://www.ncbi.nlm.nih.gov/gene/93986 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010097 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA GTSE1 http://www.ncbi.nlm.nih.gov/gene/51512 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010098 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA H2AFV http://www.ncbi.nlm.nih.gov/gene/94239 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010099 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA HECTD3 http://www.ncbi.nlm.nih.gov/gene/79654 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010100 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA HMGB2 http://www.ncbi.nlm.nih.gov/gene/3148 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010101 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA JARID2 http://www.ncbi.nlm.nih.gov/gene/3720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010102 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA KDM6A http://www.ncbi.nlm.nih.gov/gene/7403 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010103 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA KHSRP http://www.ncbi.nlm.nih.gov/gene/8570 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010104 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA KIAA0494 http://www.ncbi.nlm.nih.gov/gene/9813 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010105 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA KIAA1826 http://www.ncbi.nlm.nih.gov/gene/84437 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010106 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA KSR1 http://www.ncbi.nlm.nih.gov/gene/8844 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010107 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA KTELC1 http://www.ncbi.nlm.nih.gov/gene/56983 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010108 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA LIN54 http://www.ncbi.nlm.nih.gov/gene/132660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010109 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA LTV1 http://www.ncbi.nlm.nih.gov/gene/100128319 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010110 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA MAK16 http://www.ncbi.nlm.nih.gov/gene/84549 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010111 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA MBLAC2 http://www.ncbi.nlm.nih.gov/gene/153364 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010112 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA MET http://www.ncbi.nlm.nih.gov/gene/4233 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010113 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA MIER1 http://www.ncbi.nlm.nih.gov/gene/57708 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010114 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA MTMR9 http://www.ncbi.nlm.nih.gov/gene/66036 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010115 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA MTUS1 http://www.ncbi.nlm.nih.gov/gene/57509 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010116 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA NDUFA7 http://www.ncbi.nlm.nih.gov/gene/4701 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010117 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA ORMDL3 http://www.ncbi.nlm.nih.gov/gene/94103 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010118 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA PDE7A http://www.ncbi.nlm.nih.gov/gene/5150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010119 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA PI4KB http://www.ncbi.nlm.nih.gov/gene/5298 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010120 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA PKIA http://www.ncbi.nlm.nih.gov/gene/5569 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010121 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA PPAT http://www.ncbi.nlm.nih.gov/gene/5471 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010122 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA PPIF http://www.ncbi.nlm.nih.gov/gene/10105 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010123 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA PPP1R12A http://www.ncbi.nlm.nih.gov/gene/4659 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010124 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA RAB2B http://www.ncbi.nlm.nih.gov/gene/84932 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010125 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA RAB4A http://www.ncbi.nlm.nih.gov/gene/5867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010126 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA RAD51AP1 http://www.ncbi.nlm.nih.gov/gene/10635 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010127 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA RNF168 http://www.ncbi.nlm.nih.gov/gene/165918 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010128 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA RNF19A http://www.ncbi.nlm.nih.gov/gene/25897 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010129 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA RPL31 http://www.ncbi.nlm.nih.gov/gene/653773 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010130 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA SEC14L1 http://www.ncbi.nlm.nih.gov/gene/6397 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010131 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA SESN2 http://www.ncbi.nlm.nih.gov/gene/83667 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010132 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA SLC25A36 http://www.ncbi.nlm.nih.gov/gene/55186 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010133 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA SLC25A4 http://www.ncbi.nlm.nih.gov/gene/291 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010134 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA SLC38A2 http://www.ncbi.nlm.nih.gov/gene/54407 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010135 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA SLC7A1 http://www.ncbi.nlm.nih.gov/gene/6541 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010136 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA SLC7A6OS http://www.ncbi.nlm.nih.gov/gene/84138 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010137 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA SRGN http://www.ncbi.nlm.nih.gov/gene/5552 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010138 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA STAT5B http://www.ncbi.nlm.nih.gov/gene/6777 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010139 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA STBD1 http://www.ncbi.nlm.nih.gov/gene/8987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010140 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA STX12 http://www.ncbi.nlm.nih.gov/gene/23673 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010141 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA SYT1 http://www.ncbi.nlm.nih.gov/gene/6857 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010142 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA THOC7 http://www.ncbi.nlm.nih.gov/gene/80145 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010143 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA TMEM50A http://www.ncbi.nlm.nih.gov/gene/23585 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010144 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA TNFRSF10B http://www.ncbi.nlm.nih.gov/gene/8795 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010145 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA TNPO1 http://www.ncbi.nlm.nih.gov/gene/3842 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010146 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA TNRC6A http://www.ncbi.nlm.nih.gov/gene/27327 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010147 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA TNRC6B http://www.ncbi.nlm.nih.gov/gene/23112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010148 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA TRIB1 http://www.ncbi.nlm.nih.gov/gene/10221 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010149 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA TRIM36 http://www.ncbi.nlm.nih.gov/gene/55521 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010150 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA TSNAX http://www.ncbi.nlm.nih.gov/gene/7257 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010151 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA TSPYL5 http://www.ncbi.nlm.nih.gov/gene/85453 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010152 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA TTC35 http://www.ncbi.nlm.nih.gov/gene/9694 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010153 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA VKORC1L1 http://www.ncbi.nlm.nih.gov/gene/154807 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010154 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA VRK3 http://www.ncbi.nlm.nih.gov/gene/51231 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010155 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA WBP2 http://www.ncbi.nlm.nih.gov/gene/23558 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010156 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA ZNF544 http://www.ncbi.nlm.nih.gov/gene/27300 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010157 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA ZNF550 http://www.ncbi.nlm.nih.gov/gene/162972 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010158 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA ZNF588 http://www.ncbi.nlm.nih.gov/gene/51427 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010159 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA ZNF780B http://www.ncbi.nlm.nih.gov/gene/163131 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010160 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 BC-3 - Host mRNA ZNF90 http://www.ncbi.nlm.nih.gov/gene/7643 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010161 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 Primary effusion lymphoma (PEL) cell lines - Host Protein LRRC8D http://www.ncbi.nlm.nih.gov/gene/55144 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00010162 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 Primary effusion lymphoma (PEL) cell lines - Host Protein NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00010163 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3(miR-K3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 Primary effusion lymphoma (PEL) cell lines - Host Protein NHP2L1 http://www.ncbi.nlm.nih.gov/gene/4809 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00010164 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3-3p(miR-K12-3-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002194 Lymphocytes - Host Protein THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 KSHV miR-K12-1, miR-K12-3-3p, miR-K12-6-3p, and miR-K12-11 reduce the expression of THBS1(thrombospondin 1) by interaction with the THBS1 4' UTR. VHID00010165 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-3-3p(miR-K12-3-3p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 - - Host mRNA THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VHID00010166 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-4-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 - - Host Protein GEMIN8 http://www.ncbi.nlm.nih.gov/gene/54960 - 3'UTR dual-luciferase assay. 20413099 We identified a high confidence interaction site for kshv-miR-K12-4-3p in the coding sequence of GEMIN8 and for kshv-miR-K12-3 in the coding sequence of NHP2L1. VHID00010167 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-4-3p(miR-K4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 Primary effusion lymphoma (PEL) cell lines - Host Protein GEMIN8 http://www.ncbi.nlm.nih.gov/gene/54960 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00010168 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 - - Host Protein RBL2 http://www.ncbi.nlm.nih.gov/gene/5934 - ChIP and KSHV genome array, Quantitative RT-PCR, MeDIP, Luciferase assay, Infection, Reconstitution of recombinant virus, Genome copy number assay, Cells and plasmids. 20071580 Viral miRNA, K12-4-5p, was found to have a sequence targeting retinoblastoma (Rb)-like protein 2 (Rbl2), which is a known repressor of DNA methyl transferase 3a and 3b mRNA transcription. We show that ectopic expression of miR-K12-4-5p reduces Rbl2 protein expression and increases DNMT1, -3a, and -3b mRNA levels relative to the levels for control cells. VHID00010169 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-4-5p(miR-K4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 Primary effusion lymphoma (PEL) cell lines - Host Protein RBL2 http://www.ncbi.nlm.nih.gov/gene/5934 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00010170 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC3 - Host mRNA NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00010171 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC3 - Host mRNA NHP2L1 http://www.ncbi.nlm.nih.gov/gene/4809 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00010172 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BCBL1 - Host mRNA NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - HITS-CLIP. 17381317 Recovery of previously experimentally verified targets of KSHV miRNAs by Ago-HITS-CLIP. VHID00010173 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K12-5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 - - Host Protein BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00010174 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K12-5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 - - Host mRNA BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VHID00010175 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K12-5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 - - Host mRNA BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00010176 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K12-5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 - - Host mRNA MYD88 http://www.ncbi.nlm.nih.gov/gene/4615 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00010177 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 - - Host Protein BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00010178 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ABHD10 http://www.ncbi.nlm.nih.gov/gene/55347 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010179 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA AGGF1 http://www.ncbi.nlm.nih.gov/gene/55109 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010180 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ANKRD46 http://www.ncbi.nlm.nih.gov/gene/157567 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010181 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ANKRD52 http://www.ncbi.nlm.nih.gov/gene/283373 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010182 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ANO6 http://www.ncbi.nlm.nih.gov/gene/196527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010183 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ANXA1 http://www.ncbi.nlm.nih.gov/gene/301 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010184 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA APOBEC3C http://www.ncbi.nlm.nih.gov/gene/27350 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010185 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ARHGAP11A http://www.ncbi.nlm.nih.gov/gene/89839 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010186 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ARIH1 http://www.ncbi.nlm.nih.gov/gene/25820 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010187 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ATF7 http://www.ncbi.nlm.nih.gov/gene/11016 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010188 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ATIC http://www.ncbi.nlm.nih.gov/gene/471 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010189 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ATXN1L http://www.ncbi.nlm.nih.gov/gene/342371 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010190 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA BAHD1 http://www.ncbi.nlm.nih.gov/gene/22893 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010191 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA BNC2 http://www.ncbi.nlm.nih.gov/gene/54796 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010192 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA BRPF3 http://www.ncbi.nlm.nih.gov/gene/27154 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010193 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA BTBD3 http://www.ncbi.nlm.nih.gov/gene/22903 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010194 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA C14orf135 http://www.ncbi.nlm.nih.gov/gene/64430 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010195 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA C17orf45 http://www.ncbi.nlm.nih.gov/gene/125144 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010196 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA C17orf63 http://www.ncbi.nlm.nih.gov/gene/55731 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010197 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA C18orf21 http://www.ncbi.nlm.nih.gov/gene/83608 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010198 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA C18orf54 http://www.ncbi.nlm.nih.gov/gene/162681 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010199 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA C20orf177 http://www.ncbi.nlm.nih.gov/gene/63939 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010200 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA C21orf66 http://www.ncbi.nlm.nih.gov/gene/94104 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010201 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA C2orf43 http://www.ncbi.nlm.nih.gov/gene/60526 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010202 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA C4orf46 http://www.ncbi.nlm.nih.gov/gene/201725 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010203 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA C5orf51 http://www.ncbi.nlm.nih.gov/gene/285636 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010204 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA CAB39 http://www.ncbi.nlm.nih.gov/gene/51719 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010205 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA CBARA1 http://www.ncbi.nlm.nih.gov/gene/10367 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010206 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA CBX3 http://www.ncbi.nlm.nih.gov/gene/11335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010207 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010208 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA CD46 http://www.ncbi.nlm.nih.gov/gene/4179 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010209 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA CD59 http://www.ncbi.nlm.nih.gov/gene/966 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010210 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA CEP97 http://www.ncbi.nlm.nih.gov/gene/79598 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010211 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA CLK1 http://www.ncbi.nlm.nih.gov/gene/1195 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010212 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA CNOT6 http://www.ncbi.nlm.nih.gov/gene/57472 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010213 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA CSNK1G1 http://www.ncbi.nlm.nih.gov/gene/53944 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010214 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA CSRNP2 http://www.ncbi.nlm.nih.gov/gene/81566 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010215 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA CXorf15 http://www.ncbi.nlm.nih.gov/gene/55787 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010216 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA DCP1A http://www.ncbi.nlm.nih.gov/gene/55802 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010217 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA DDX17 http://www.ncbi.nlm.nih.gov/gene/10521 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010218 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA DFFA http://www.ncbi.nlm.nih.gov/gene/1676 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010219 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA DLD http://www.ncbi.nlm.nih.gov/gene/1738 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010220 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA DMXL2 http://www.ncbi.nlm.nih.gov/gene/23312 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010221 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA DNAJC13 http://www.ncbi.nlm.nih.gov/gene/23317 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010222 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA DNAJC5 http://www.ncbi.nlm.nih.gov/gene/80331 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010223 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA DNM1P17 http://www.ncbi.nlm.nih.gov/gene/100131084 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010224 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA EAF2 http://www.ncbi.nlm.nih.gov/gene/55840 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010225 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA EIF2A http://www.ncbi.nlm.nih.gov/gene/83939 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010226 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ENC1 http://www.ncbi.nlm.nih.gov/gene/8507 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010227 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA FAM133A http://www.ncbi.nlm.nih.gov/gene/286499 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010228 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA FAM134A http://www.ncbi.nlm.nih.gov/gene/79137 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010229 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA FAM171B http://www.ncbi.nlm.nih.gov/gene/165215 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010230 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA FBN1 http://www.ncbi.nlm.nih.gov/gene/2200 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010231 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA FBXO22 http://www.ncbi.nlm.nih.gov/gene/26263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010232 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA FBXO41 http://www.ncbi.nlm.nih.gov/gene/150726 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010233 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA FBXW11 http://www.ncbi.nlm.nih.gov/gene/23291 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010234 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA FEM1A http://www.ncbi.nlm.nih.gov/gene/55527 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010235 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA FNDC3A http://www.ncbi.nlm.nih.gov/gene/22862 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010236 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA FOXK1 http://www.ncbi.nlm.nih.gov/gene/221937 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010237 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA GBP3 http://www.ncbi.nlm.nih.gov/gene/2635 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010238 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA GCC1 http://www.ncbi.nlm.nih.gov/gene/79571 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010239 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA GGA3 http://www.ncbi.nlm.nih.gov/gene/23163 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010240 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA GOPC http://www.ncbi.nlm.nih.gov/gene/57120 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010241 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA GOT2 http://www.ncbi.nlm.nih.gov/gene/2806 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010242 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA GRIN2A http://www.ncbi.nlm.nih.gov/gene/2903 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010243 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA GTF2F1 http://www.ncbi.nlm.nih.gov/gene/2962 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010244 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA HJURP http://www.ncbi.nlm.nih.gov/gene/55355 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010245 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA HNRNPC http://www.ncbi.nlm.nih.gov/gene/3183 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010246 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA HSDL1 http://www.ncbi.nlm.nih.gov/gene/83693 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010247 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA IGDCC4 http://www.ncbi.nlm.nih.gov/gene/57722 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010248 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA IKZF3 http://www.ncbi.nlm.nih.gov/gene/22806 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010249 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA IQSEC1 http://www.ncbi.nlm.nih.gov/gene/9922 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010250 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ISG20L2 http://www.ncbi.nlm.nih.gov/gene/81875 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010251 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ITGA6 http://www.ncbi.nlm.nih.gov/gene/3655 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010252 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA JARID2 http://www.ncbi.nlm.nih.gov/gene/3720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010253 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA JMJD6 http://www.ncbi.nlm.nih.gov/gene/23210 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010254 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA JMY http://www.ncbi.nlm.nih.gov/gene/133746 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010255 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA KDELR2 http://www.ncbi.nlm.nih.gov/gene/11014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010256 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA KIAA0240 http://www.ncbi.nlm.nih.gov/gene/23506 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010257 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA KIAA0247 http://www.ncbi.nlm.nih.gov/gene/9766 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010258 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA KIAA0323 http://www.ncbi.nlm.nih.gov/gene/23351 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010259 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA KIAA0528 http://www.ncbi.nlm.nih.gov/gene/9847 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010260 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA KIAA0895 http://www.ncbi.nlm.nih.gov/gene/23366 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010261 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA KIF11 http://www.ncbi.nlm.nih.gov/gene/3832 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010262 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA KLHDC5 http://www.ncbi.nlm.nih.gov/gene/57542 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010263 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA KLHL9 http://www.ncbi.nlm.nih.gov/gene/55958 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010264 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA KPNA1 http://www.ncbi.nlm.nih.gov/gene/3836 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010265 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA LARP1 http://www.ncbi.nlm.nih.gov/gene/23367 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010266 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA LCP1 http://www.ncbi.nlm.nih.gov/gene/3936 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010267 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA LEF1 http://www.ncbi.nlm.nih.gov/gene/51176 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010268 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA LIPA http://www.ncbi.nlm.nih.gov/gene/3988 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010269 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA LSM6 http://www.ncbi.nlm.nih.gov/gene/11157 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010270 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA MAML1 http://www.ncbi.nlm.nih.gov/gene/9794 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010271 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA MCFD2 http://www.ncbi.nlm.nih.gov/gene/90411 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010272 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA METT10D http://www.ncbi.nlm.nih.gov/gene/79066 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010273 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA MFAP3 http://www.ncbi.nlm.nih.gov/gene/4238 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010274 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA MFAP3L http://www.ncbi.nlm.nih.gov/gene/9848 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010275 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA MLL3 http://www.ncbi.nlm.nih.gov/gene/58508 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010276 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA MOBKL1B http://www.ncbi.nlm.nih.gov/gene/55233 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010277 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA MPHOSPH8 http://www.ncbi.nlm.nih.gov/gene/54737 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010278 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA MPP5 http://www.ncbi.nlm.nih.gov/gene/64398 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010279 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA MRPL45 http://www.ncbi.nlm.nih.gov/gene/84311 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010280 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA MRPS35 http://www.ncbi.nlm.nih.gov/gene/60488 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010281 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA MTHFD2L http://www.ncbi.nlm.nih.gov/gene/441024 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010282 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA NAT15 http://www.ncbi.nlm.nih.gov/gene/79903 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010283 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA NDRG1 http://www.ncbi.nlm.nih.gov/gene/10397 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010284 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA NEO1 http://www.ncbi.nlm.nih.gov/gene/4756 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010285 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA NF1 http://www.ncbi.nlm.nih.gov/gene/4763 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010286 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010287 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA NFYB http://www.ncbi.nlm.nih.gov/gene/4801 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010288 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA NIPA1 http://www.ncbi.nlm.nih.gov/gene/123606 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010289 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA NOTCH2 http://www.ncbi.nlm.nih.gov/gene/4853 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010290 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA NUP62CL http://www.ncbi.nlm.nih.gov/gene/54830 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010291 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA PDCL http://www.ncbi.nlm.nih.gov/gene/5082 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010292 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA PHF17 http://www.ncbi.nlm.nih.gov/gene/79960 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010293 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA PIAS4 http://www.ncbi.nlm.nih.gov/gene/51588 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010294 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA PNN http://www.ncbi.nlm.nih.gov/gene/5411 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010295 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA POLH http://www.ncbi.nlm.nih.gov/gene/5429 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010296 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA POLR3D http://www.ncbi.nlm.nih.gov/gene/661 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010297 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA PPARA http://www.ncbi.nlm.nih.gov/gene/5465 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010298 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA PPM1B http://www.ncbi.nlm.nih.gov/gene/5495 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010299 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA PPP1R8 http://www.ncbi.nlm.nih.gov/gene/5511 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010300 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA PPP3CA http://www.ncbi.nlm.nih.gov/gene/5530 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010301 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA PRPS2 http://www.ncbi.nlm.nih.gov/gene/5634 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010302 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA PSKH1 http://www.ncbi.nlm.nih.gov/gene/5681 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010303 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA PSMB5 http://www.ncbi.nlm.nih.gov/gene/5693 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010304 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA RAB5B http://www.ncbi.nlm.nih.gov/gene/5869 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010305 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA RAPH1 http://www.ncbi.nlm.nih.gov/gene/65059 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010306 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA RBAK http://www.ncbi.nlm.nih.gov/gene/389458 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010307 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA RBM26 http://www.ncbi.nlm.nih.gov/gene/64062 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010308 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA RCOR1 http://www.ncbi.nlm.nih.gov/gene/23186 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010309 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA RCSD1 http://www.ncbi.nlm.nih.gov/gene/92241 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010310 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA RGL1 http://www.ncbi.nlm.nih.gov/gene/23179 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010311 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA RNF216 http://www.ncbi.nlm.nih.gov/gene/54476 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010312 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA RORA http://www.ncbi.nlm.nih.gov/gene/6095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010313 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA RRAGA http://www.ncbi.nlm.nih.gov/gene/10670 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010314 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA SAR1B http://www.ncbi.nlm.nih.gov/gene/51128 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010315 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA SEPSECS http://www.ncbi.nlm.nih.gov/gene/51091 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010316 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA SERTAD2 http://www.ncbi.nlm.nih.gov/gene/9792 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010317 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA SLC30A7 http://www.ncbi.nlm.nih.gov/gene/148867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010318 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA SLC44A1 http://www.ncbi.nlm.nih.gov/gene/23446 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010319 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA SLC5A3 http://www.ncbi.nlm.nih.gov/gene/6526 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010320 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA SLC7A6 http://www.ncbi.nlm.nih.gov/gene/9057 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010321 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA SMURF2 http://www.ncbi.nlm.nih.gov/gene/64750 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010322 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA SMYD5 http://www.ncbi.nlm.nih.gov/gene/10322 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010323 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA SRPK1 http://www.ncbi.nlm.nih.gov/gene/6732 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010324 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA STAU2 http://www.ncbi.nlm.nih.gov/gene/27067 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010325 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA STRN3 http://www.ncbi.nlm.nih.gov/gene/29966 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010326 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA TAOK1 http://www.ncbi.nlm.nih.gov/gene/57551 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010327 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA TBC1D20 http://www.ncbi.nlm.nih.gov/gene/128637 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010328 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA TBK1 http://www.ncbi.nlm.nih.gov/gene/29110 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010329 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA TECPR2 http://www.ncbi.nlm.nih.gov/gene/9895 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010330 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA TFPI http://www.ncbi.nlm.nih.gov/gene/7035 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010331 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA TH1L http://www.ncbi.nlm.nih.gov/gene/51497 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010332 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA TLN2 http://www.ncbi.nlm.nih.gov/gene/83660 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010333 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA TM9SF3 http://www.ncbi.nlm.nih.gov/gene/56889 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010334 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA TMCO1 http://www.ncbi.nlm.nih.gov/gene/54499 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010335 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA TNRC6B http://www.ncbi.nlm.nih.gov/gene/23112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010336 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA TRAM2 http://www.ncbi.nlm.nih.gov/gene/9697 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010337 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA TRAPPC10 http://www.ncbi.nlm.nih.gov/gene/7109 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010338 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA TRIM23 http://www.ncbi.nlm.nih.gov/gene/373 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010339 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA TRIM27 http://www.ncbi.nlm.nih.gov/gene/5987 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010340 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA TRIM65 http://www.ncbi.nlm.nih.gov/gene/201292 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010341 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA TSG101 http://www.ncbi.nlm.nih.gov/gene/7251 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010342 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA USP5 http://www.ncbi.nlm.nih.gov/gene/8078 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010343 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA VANGL1 http://www.ncbi.nlm.nih.gov/gene/81839 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010344 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA VCPIP1 http://www.ncbi.nlm.nih.gov/gene/80124 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010345 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA VGLL4 http://www.ncbi.nlm.nih.gov/gene/9686 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010346 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA VPS54 http://www.ncbi.nlm.nih.gov/gene/51542 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010347 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ZNF160 http://www.ncbi.nlm.nih.gov/gene/90338 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010348 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ZNF248 http://www.ncbi.nlm.nih.gov/gene/57209 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010349 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ZNF264 http://www.ncbi.nlm.nih.gov/gene/9422 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010350 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ZNF333 http://www.ncbi.nlm.nih.gov/gene/84449 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010351 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ZNF490 http://www.ncbi.nlm.nih.gov/gene/57474 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010352 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ZNF518A http://www.ncbi.nlm.nih.gov/gene/9849 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010353 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ZNF543 http://www.ncbi.nlm.nih.gov/gene/125919 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010354 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ZNF620 http://www.ncbi.nlm.nih.gov/gene/253639 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010355 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-1 - Host mRNA ZNF800 http://www.ncbi.nlm.nih.gov/gene/168850 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010356 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA ABHD10 http://www.ncbi.nlm.nih.gov/gene/55347 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010357 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA AGGF1 http://www.ncbi.nlm.nih.gov/gene/55109 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010358 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA ANKRD46 http://www.ncbi.nlm.nih.gov/gene/157567 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010359 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA BAHD1 http://www.ncbi.nlm.nih.gov/gene/22893 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010360 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA BNC2 http://www.ncbi.nlm.nih.gov/gene/54796 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010361 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA BTBD3 http://www.ncbi.nlm.nih.gov/gene/22903 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010362 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA C17orf45 http://www.ncbi.nlm.nih.gov/gene/125144 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010363 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA C17orf63 http://www.ncbi.nlm.nih.gov/gene/55731 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010364 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA C18orf21 http://www.ncbi.nlm.nih.gov/gene/83608 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010365 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA C18orf54 http://www.ncbi.nlm.nih.gov/gene/162681 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010366 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA C20orf177 http://www.ncbi.nlm.nih.gov/gene/63939 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010367 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA C2orf43 http://www.ncbi.nlm.nih.gov/gene/60526 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010368 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA C5orf51 http://www.ncbi.nlm.nih.gov/gene/285636 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010369 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA CAB39 http://www.ncbi.nlm.nih.gov/gene/51719 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010370 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA CBARA1 http://www.ncbi.nlm.nih.gov/gene/10367 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010371 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA CBFA2T2 http://www.ncbi.nlm.nih.gov/gene/9139 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010372 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA CBX3 http://www.ncbi.nlm.nih.gov/gene/11335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010373 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA CEP97 http://www.ncbi.nlm.nih.gov/gene/79598 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010374 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA CLK1 http://www.ncbi.nlm.nih.gov/gene/1195 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010375 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA CNOT6 http://www.ncbi.nlm.nih.gov/gene/57472 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010376 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA CSRNP2 http://www.ncbi.nlm.nih.gov/gene/81566 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010377 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA CXCL10 http://www.ncbi.nlm.nih.gov/gene/3627 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010378 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA DFFA http://www.ncbi.nlm.nih.gov/gene/1676 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010379 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA DHX36 http://www.ncbi.nlm.nih.gov/gene/170506 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010380 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA DNAJC5 http://www.ncbi.nlm.nih.gov/gene/80331 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010381 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA EIF2A http://www.ncbi.nlm.nih.gov/gene/83939 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010382 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA FAM134A http://www.ncbi.nlm.nih.gov/gene/79137 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010383 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA FBN1 http://www.ncbi.nlm.nih.gov/gene/2200 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010384 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA GCC1 http://www.ncbi.nlm.nih.gov/gene/79571 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010385 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA GGA3 http://www.ncbi.nlm.nih.gov/gene/23163 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010386 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA GTF2F1 http://www.ncbi.nlm.nih.gov/gene/2962 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010387 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA IGDCC4 http://www.ncbi.nlm.nih.gov/gene/57722 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010388 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA IKZF3 http://www.ncbi.nlm.nih.gov/gene/22806 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010389 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA ISG20L2 http://www.ncbi.nlm.nih.gov/gene/81875 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010390 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA JARID2 http://www.ncbi.nlm.nih.gov/gene/3720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010391 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA KDELR2 http://www.ncbi.nlm.nih.gov/gene/11014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010392 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA KIAA0247 http://www.ncbi.nlm.nih.gov/gene/9766 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010393 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA KIAA0528 http://www.ncbi.nlm.nih.gov/gene/9847 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010394 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA KIAA0895 http://www.ncbi.nlm.nih.gov/gene/23366 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010395 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA KLHL9 http://www.ncbi.nlm.nih.gov/gene/55958 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010396 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA KPNA1 http://www.ncbi.nlm.nih.gov/gene/3836 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010397 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA MAML1 http://www.ncbi.nlm.nih.gov/gene/9794 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010398 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA MCFD2 http://www.ncbi.nlm.nih.gov/gene/90411 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010399 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA MPHOSPH8 http://www.ncbi.nlm.nih.gov/gene/54737 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010400 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA MPP5 http://www.ncbi.nlm.nih.gov/gene/64398 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010401 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA MRPS35 http://www.ncbi.nlm.nih.gov/gene/60488 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010402 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA MYD88 http://www.ncbi.nlm.nih.gov/gene/4615 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010403 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA NDRG1 http://www.ncbi.nlm.nih.gov/gene/10397 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010404 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010405 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA NOTCH2 http://www.ncbi.nlm.nih.gov/gene/4853 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010406 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA PDCL http://www.ncbi.nlm.nih.gov/gene/5082 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010407 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA PFKFB3 http://www.ncbi.nlm.nih.gov/gene/5209 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010408 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA PHF17 http://www.ncbi.nlm.nih.gov/gene/79960 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010409 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA PIAS4 http://www.ncbi.nlm.nih.gov/gene/51588 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010410 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA POLH http://www.ncbi.nlm.nih.gov/gene/5429 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010411 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA POLR3D http://www.ncbi.nlm.nih.gov/gene/661 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010412 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA PPM1B http://www.ncbi.nlm.nih.gov/gene/5495 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010413 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA PPP1R8 http://www.ncbi.nlm.nih.gov/gene/5511 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010414 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA RAB5B http://www.ncbi.nlm.nih.gov/gene/5869 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010415 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA RGL1 http://www.ncbi.nlm.nih.gov/gene/23179 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010416 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA RNF34 http://www.ncbi.nlm.nih.gov/gene/80196 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010417 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA SEPSECS http://www.ncbi.nlm.nih.gov/gene/51091 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010418 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA SERTAD2 http://www.ncbi.nlm.nih.gov/gene/9792 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010419 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA SETD5 http://www.ncbi.nlm.nih.gov/gene/55209 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010420 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA SLC30A7 http://www.ncbi.nlm.nih.gov/gene/148867 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010421 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA SLC7A6 http://www.ncbi.nlm.nih.gov/gene/9057 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010422 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA STC2 http://www.ncbi.nlm.nih.gov/gene/8614 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010423 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA STRN3 http://www.ncbi.nlm.nih.gov/gene/29966 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010424 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA TAOK1 http://www.ncbi.nlm.nih.gov/gene/57551 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010425 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA TBK1 http://www.ncbi.nlm.nih.gov/gene/29110 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010426 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA TECPR2 http://www.ncbi.nlm.nih.gov/gene/9895 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010427 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA TFPI http://www.ncbi.nlm.nih.gov/gene/7035 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010428 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA TMCO1 http://www.ncbi.nlm.nih.gov/gene/54499 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010429 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA TRAM2 http://www.ncbi.nlm.nih.gov/gene/9697 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010430 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA TRIM65 http://www.ncbi.nlm.nih.gov/gene/201292 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010431 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA TSG101 http://www.ncbi.nlm.nih.gov/gene/7251 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010432 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA VGLL4 http://www.ncbi.nlm.nih.gov/gene/9686 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010433 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA VPS54 http://www.ncbi.nlm.nih.gov/gene/51542 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010434 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA ZBTB2 http://www.ncbi.nlm.nih.gov/gene/57621 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010435 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA ZNF160 http://www.ncbi.nlm.nih.gov/gene/90338 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010436 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA ZNF248 http://www.ncbi.nlm.nih.gov/gene/57209 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010437 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BC-3 - Host mRNA ZNF490 http://www.ncbi.nlm.nih.gov/gene/57474 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010438 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 BJAB and BCBL-3 cells - Host Protein BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 Downregulation Immunoblotting and apoptosis, Luciferase assays, Microarrays, Sequence Analysis, miRNA expression. 19098914 The functional consequence of this downregulation for KSHV latency can be assessed by examining the effects of BCLAF1 modulation on viral replication. When latently infected cells are chemically induced to lytic KSHV growth, antagonism of miRs K5,9, 10a and 10b is associated with decreased virion production (Fig. 5a) and increased BCLAF1 expression (Fig. 5c). This suggests that BCLAF1 action acts to impair lytic viral replication. VHID00010439 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 Primary effusion lymphoma (PEL) cell lines - Host Protein BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00010440 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-6(miR-K12-6) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002480 - - Host Protein MAF http://www.ncbi.nlm.nih.gov/gene/4094 - Iferase reporter assays, miRNA target prediction analysis, KSHV production and infection of LECs, qPCR and qRT-PCR, Western blotting, Gene expression and miRNA microarray profiling, Subcloning of KSHV miRNAs into pSIN-MCS, GSEA, Gene expression and miRNA microarray. 20080955 MAF is a target for KSHV-encoded miRNAs.Although miR-K12-6 and miR-K12-11 induced MAF repression, the strongest down-regulation was caused by the entire cluster . VHID00010441 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-6(miR-K12-6) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002480 Lymphocytes - Host Protein MAF http://www.ncbi.nlm.nih.gov/gene/4094 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 miR-K12-1,-6, and -11 decrease of MAF(musculoaponeurotic fibrosarcoma oncogene homolog), K12-4-5p targeting retinoblastoma(Rb)-like protein 2(Rbl2). VHID00010442 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-6(miR-K12-6-3p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002480 - - Host mRNA THBS1 http://www.ncbi.nlm.nih.gov/gene/7057 - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VHID00010443 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 Primary effusion lymphoma (PEL) cell lines - Host Protein BACH1 http://www.ncbi.nlm.nih.gov/gene/571 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00010444 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(MiR-K12-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 Natural Killer (NK) cell - Host mRNA MICB http://www.ncbi.nlm.nih.gov/gene/4277 Downregulation Western Blot,Quantitative Real-Time PCR, Luciferase Assay. 19380116 KSHV and EBV Downregulate MICB Expression via a MiRNA-Based Translational Repression Mechanism.MiR-K12-7 and MiR-BART2-5p Directly Bind to the 3'UTR of MICB. VHID00010445 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(kshv-miR-K12-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 - - Host mRNA MICB http://www.ncbi.nlm.nih.gov/gene/4277 - Quantitative Real-Time PCR, Luciferase Assay, Western Blot. 20413099 Recently, the activating NK cell ligand MICB was found to be targeted by both ebv-miR-BART2-5p, kshv-miR-K12-7 and hcmvmiR-UL112-1. VHID00010446 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K12-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 - - Host Protein CEBPB http://www.ncbi.nlm.nih.gov/gene/1051 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00010447 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K12-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 - - Host Protein LIP http://www.ncbi.nlm.nih.gov/gene/23049 Downregulation KSHV miRNA target identification, ELISA, TLR inhibition assays, immunoblot analyses, Immunoblots, RT-PCR. 20052801 Subsequent immunoblot analyses revealed that miR-K12-3 and miR-K12-7 preferentially reduce expression of C/EBPbeta p20 (LIP), an isoform of C/EBPbeta known to function as a negative transcription regulator. VHID00010448 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K12-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 - - Host Protein LIP http://www.ncbi.nlm.nih.gov/gene/23049 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00010449 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K12-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 - - Host Protein MICB http://www.ncbi.nlm.nih.gov/gene/4277 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00010450 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K12-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 - - Host Protein MICB http://www.ncbi.nlm.nih.gov/gene/4277 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00010451 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K12-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 - - Host mRNA CEBPE(C/EBP) http://www.ncbi.nlm.nih.gov/gene/1053 - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VHID00010452 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K12-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 - - Host mRNA MICB http://www.ncbi.nlm.nih.gov/gene/4277 - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VHID00010453 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K12-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 - - Host mRNA MICB http://www.ncbi.nlm.nih.gov/gene/4277 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00010454 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K12-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 - - Host mRNA MICB http://www.ncbi.nlm.nih.gov/gene/4277 Downregulation Quantitative Real-Time PCR, Luciferase Assay, Western Blot. 19380116 Both KSHV and EBV encode a miRNA that downregulates MICB, the two viral miRNAs, miR-K12-7 and miR-BART2-5p, specifically downregulate MICB expression to avoid attack by immune cells. VHID00010455 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 - - Host Protein MICB http://www.ncbi.nlm.nih.gov/gene/4277 - And Transduction, RNA Duplex and Transfection, Production, Cytotoxicity Assay and NK Cell Preparation, Quantitative Real-Time PCR, DNA Constructs and Luciferase Assay, Lentiviral Constructs, Western Blot. 19380116 Thus, we identified the specific binding sites of miR-K12-7 and of miR-BART2-5p in the 3'UTR of MICB and can now consider the strategy of MICB miRNA targeting as a common trait of human herpesviruses. VHID00010456 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA ADIPOR2 http://www.ncbi.nlm.nih.gov/gene/79602 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010457 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA ARHGAP12 http://www.ncbi.nlm.nih.gov/gene/94134 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010458 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA ARHGEF2 http://www.ncbi.nlm.nih.gov/gene/9181 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010459 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA ASH1L http://www.ncbi.nlm.nih.gov/gene/55870 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010460 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA ATG16L1 http://www.ncbi.nlm.nih.gov/gene/55054 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010461 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA BEND3 http://www.ncbi.nlm.nih.gov/gene/57673 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010462 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA BNC2 http://www.ncbi.nlm.nih.gov/gene/54796 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010463 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA BNIP2 http://www.ncbi.nlm.nih.gov/gene/663 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010464 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA C2orf18 http://www.ncbi.nlm.nih.gov/gene/54978 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010465 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA C2orf49 http://www.ncbi.nlm.nih.gov/gene/79074 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010466 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA CANT1 http://www.ncbi.nlm.nih.gov/gene/124583 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010467 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA CAPN7 http://www.ncbi.nlm.nih.gov/gene/23473 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010468 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA CASP7 http://www.ncbi.nlm.nih.gov/gene/840 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010469 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010470 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA CHRNB1 http://www.ncbi.nlm.nih.gov/gene/1140 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010471 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA CLCN5 http://www.ncbi.nlm.nih.gov/gene/1184 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010472 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA CLEC2B http://www.ncbi.nlm.nih.gov/gene/9976 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010473 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA COMMD1 http://www.ncbi.nlm.nih.gov/gene/150684 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010474 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA COX7A2 http://www.ncbi.nlm.nih.gov/gene/1347 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010475 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA CRK http://www.ncbi.nlm.nih.gov/gene/1398 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010476 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA CRKL http://www.ncbi.nlm.nih.gov/gene/1399 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010477 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA CSRNP2 http://www.ncbi.nlm.nih.gov/gene/81566 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010478 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA DEAF1 http://www.ncbi.nlm.nih.gov/gene/10522 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010479 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA EPC2 http://www.ncbi.nlm.nih.gov/gene/26122 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010480 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA FAM168B http://www.ncbi.nlm.nih.gov/gene/130074 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010481 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA FAM76B http://www.ncbi.nlm.nih.gov/gene/143684 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010482 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA FGD4 http://www.ncbi.nlm.nih.gov/gene/121512 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010483 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA FOXK1 http://www.ncbi.nlm.nih.gov/gene/221937 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010484 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA FRS2 http://www.ncbi.nlm.nih.gov/gene/10818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010485 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA GAN http://www.ncbi.nlm.nih.gov/gene/8139 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010486 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA GRHL1 http://www.ncbi.nlm.nih.gov/gene/29841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010487 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA IL2RB http://www.ncbi.nlm.nih.gov/gene/3560 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010488 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA IMPDH1 http://www.ncbi.nlm.nih.gov/gene/3614 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010489 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA JHDM1D http://www.ncbi.nlm.nih.gov/gene/80853 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010490 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA KBTBD4 http://www.ncbi.nlm.nih.gov/gene/55709 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010491 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA KDM5B http://www.ncbi.nlm.nih.gov/gene/10765 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010492 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA KHSRP http://www.ncbi.nlm.nih.gov/gene/8570 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010493 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA KIF14 http://www.ncbi.nlm.nih.gov/gene/9928 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010494 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA LCORL http://www.ncbi.nlm.nih.gov/gene/254251 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010495 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA LIMA1 http://www.ncbi.nlm.nih.gov/gene/51474 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010496 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA LONP2 http://www.ncbi.nlm.nih.gov/gene/83752 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010497 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA MAML2 http://www.ncbi.nlm.nih.gov/gene/84441 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010498 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA MAP3K3 http://www.ncbi.nlm.nih.gov/gene/4215 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010499 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA MBNL2 http://www.ncbi.nlm.nih.gov/gene/10150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010500 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA MDFIC http://www.ncbi.nlm.nih.gov/gene/29969 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010501 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA MFAP3 http://www.ncbi.nlm.nih.gov/gene/4238 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010502 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA MKNK2 http://www.ncbi.nlm.nih.gov/gene/2872 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010503 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA MRPL49 http://www.ncbi.nlm.nih.gov/gene/740 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010504 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA MRPS16 http://www.ncbi.nlm.nih.gov/gene/51021 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010505 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA MTHFR http://www.ncbi.nlm.nih.gov/gene/4524 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010506 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA NDUFA8 http://www.ncbi.nlm.nih.gov/gene/4702 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010507 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA NFE2L3 http://www.ncbi.nlm.nih.gov/gene/9603 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010508 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA NUDCD3 http://www.ncbi.nlm.nih.gov/gene/23386 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010509 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA NUP43 http://www.ncbi.nlm.nih.gov/gene/348995 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010510 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA OGT http://www.ncbi.nlm.nih.gov/gene/8473 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010511 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA OSBPL2 http://www.ncbi.nlm.nih.gov/gene/9885 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010512 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA PARP16 http://www.ncbi.nlm.nih.gov/gene/54956 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010513 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA PCBP1 http://www.ncbi.nlm.nih.gov/gene/5093 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010514 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA PDCL http://www.ncbi.nlm.nih.gov/gene/5082 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010515 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA PHC3 http://www.ncbi.nlm.nih.gov/gene/80012 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010516 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA POLI http://www.ncbi.nlm.nih.gov/gene/11201 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010517 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA POLR1B http://www.ncbi.nlm.nih.gov/gene/84172 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010518 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA POP4 http://www.ncbi.nlm.nih.gov/gene/10775 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010519 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA PRDM1 http://www.ncbi.nlm.nih.gov/gene/639 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010520 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA RABGEF1 http://www.ncbi.nlm.nih.gov/gene/27342 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010521 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA RBM43 http://www.ncbi.nlm.nih.gov/gene/375287 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010522 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA RC3H2 http://www.ncbi.nlm.nih.gov/gene/54542 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010523 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA ROD1 http://www.ncbi.nlm.nih.gov/gene/9991 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010524 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA RPP30 http://www.ncbi.nlm.nih.gov/gene/10556 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010525 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA SCAMP1 http://www.ncbi.nlm.nih.gov/gene/9522 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010526 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA SCAMP2 http://www.ncbi.nlm.nih.gov/gene/10066 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010527 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA SF3A1 http://www.ncbi.nlm.nih.gov/gene/10291 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010528 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA SIN3B http://www.ncbi.nlm.nih.gov/gene/23309 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010529 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA SLC26A11 http://www.ncbi.nlm.nih.gov/gene/284129 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010530 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA SLC38A1 http://www.ncbi.nlm.nih.gov/gene/81539 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010531 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA SLC4A7 http://www.ncbi.nlm.nih.gov/gene/9497 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010532 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA SLC5A3 http://www.ncbi.nlm.nih.gov/gene/6526 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010533 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA SRXN1 http://www.ncbi.nlm.nih.gov/gene/140809 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010534 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA STAM2 http://www.ncbi.nlm.nih.gov/gene/10254 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010535 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA STARD9 http://www.ncbi.nlm.nih.gov/gene/57519 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010536 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA STRN http://www.ncbi.nlm.nih.gov/gene/6801 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010537 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA SUMO3 http://www.ncbi.nlm.nih.gov/gene/285829 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010538 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA SYNJ2BP http://www.ncbi.nlm.nih.gov/gene/55333 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010539 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA TAF2 http://www.ncbi.nlm.nih.gov/gene/6873 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010540 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA TCEB3 http://www.ncbi.nlm.nih.gov/gene/6924 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010541 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA TGIF2 http://www.ncbi.nlm.nih.gov/gene/60436 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010542 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA TNRC6B http://www.ncbi.nlm.nih.gov/gene/23112 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010543 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA TOP1 http://www.ncbi.nlm.nih.gov/gene/7150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010544 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA TRAK1 http://www.ncbi.nlm.nih.gov/gene/22906 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010545 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA TRAM2 http://www.ncbi.nlm.nih.gov/gene/9697 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010546 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA TUG1 http://www.ncbi.nlm.nih.gov/gene/55000 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010547 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA UBXN7 http://www.ncbi.nlm.nih.gov/gene/26043 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010548 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA UTP23 http://www.ncbi.nlm.nih.gov/gene/84294 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010549 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA VPS13C http://www.ncbi.nlm.nih.gov/gene/54832 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010550 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA XPO4 http://www.ncbi.nlm.nih.gov/gene/64328 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010551 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA ZBTB37 http://www.ncbi.nlm.nih.gov/gene/84614 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010552 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA ZBTB43 http://www.ncbi.nlm.nih.gov/gene/23099 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010553 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA ZMPSTE24 http://www.ncbi.nlm.nih.gov/gene/10269 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010554 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA ZNF436 http://www.ncbi.nlm.nih.gov/gene/80818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010555 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-1 - Host mRNA ZNF655 http://www.ncbi.nlm.nih.gov/gene/79027 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010556 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA ABCB8 http://www.ncbi.nlm.nih.gov/gene/11194 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010557 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA ABI2 http://www.ncbi.nlm.nih.gov/gene/10152 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010558 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA ADIPOR2 http://www.ncbi.nlm.nih.gov/gene/79602 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010559 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA ALAD http://www.ncbi.nlm.nih.gov/gene/210 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010560 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA ARHGEF2 http://www.ncbi.nlm.nih.gov/gene/9181 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010561 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA ASH1L http://www.ncbi.nlm.nih.gov/gene/55870 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010562 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA BEND3 http://www.ncbi.nlm.nih.gov/gene/57673 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010563 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA BNIP2 http://www.ncbi.nlm.nih.gov/gene/663 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010564 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA BNIP3 http://www.ncbi.nlm.nih.gov/gene/664 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010565 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA C10orf119 http://www.ncbi.nlm.nih.gov/gene/79892 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010566 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA C14orf135 http://www.ncbi.nlm.nih.gov/gene/64430 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010567 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA C2orf18 http://www.ncbi.nlm.nih.gov/gene/54978 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010568 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA CANT1 http://www.ncbi.nlm.nih.gov/gene/124583 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010569 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA CCNT2 http://www.ncbi.nlm.nih.gov/gene/905 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010570 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA CD2BP2 http://www.ncbi.nlm.nih.gov/gene/10421 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010571 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA CHRNB1 http://www.ncbi.nlm.nih.gov/gene/1140 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010572 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA COMMD1 http://www.ncbi.nlm.nih.gov/gene/150684 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010573 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA COX7A2 http://www.ncbi.nlm.nih.gov/gene/1347 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010574 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA CRKL http://www.ncbi.nlm.nih.gov/gene/1399 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010575 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA CSMD1 http://www.ncbi.nlm.nih.gov/gene/64478 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010576 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA CTH http://www.ncbi.nlm.nih.gov/gene/1491 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010577 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA DDB2 http://www.ncbi.nlm.nih.gov/gene/1643 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010578 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA DEAF1 http://www.ncbi.nlm.nih.gov/gene/10522 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010579 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA DOK1 http://www.ncbi.nlm.nih.gov/gene/220077 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010580 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA EPC2 http://www.ncbi.nlm.nih.gov/gene/26122 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010581 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA FAM46C http://www.ncbi.nlm.nih.gov/gene/54855 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010582 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA FAM76B http://www.ncbi.nlm.nih.gov/gene/143684 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010583 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA GALNT11 http://www.ncbi.nlm.nih.gov/gene/63917 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010584 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA GGA2 http://www.ncbi.nlm.nih.gov/gene/23062 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010585 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA GMFB http://www.ncbi.nlm.nih.gov/gene/2764 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010586 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA GRHL1 http://www.ncbi.nlm.nih.gov/gene/29841 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010587 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA HNRNPU http://www.ncbi.nlm.nih.gov/gene/3192 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010588 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA HOMEZ http://www.ncbi.nlm.nih.gov/gene/57594 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010589 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA IFRD1 http://www.ncbi.nlm.nih.gov/gene/3475 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010590 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA IL2RB http://www.ncbi.nlm.nih.gov/gene/3560 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010591 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA IMPDH1 http://www.ncbi.nlm.nih.gov/gene/3614 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010592 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA ITPRIP http://www.ncbi.nlm.nih.gov/gene/85450 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010593 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA JHDM1D http://www.ncbi.nlm.nih.gov/gene/80853 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010594 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA KBTBD4 http://www.ncbi.nlm.nih.gov/gene/55709 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010595 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA KDM5B http://www.ncbi.nlm.nih.gov/gene/10765 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010596 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA KHSRP http://www.ncbi.nlm.nih.gov/gene/8570 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010597 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA LIMA1 http://www.ncbi.nlm.nih.gov/gene/51474 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010598 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA MAML2 http://www.ncbi.nlm.nih.gov/gene/84441 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010599 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA MAP3K3 http://www.ncbi.nlm.nih.gov/gene/4215 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010600 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA MAP4 http://www.ncbi.nlm.nih.gov/gene/4134 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010601 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA MBNL2 http://www.ncbi.nlm.nih.gov/gene/10150 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010602 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA MEGF9 http://www.ncbi.nlm.nih.gov/gene/1955 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010603 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA MFAP3 http://www.ncbi.nlm.nih.gov/gene/4238 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010604 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA MFSD1 http://www.ncbi.nlm.nih.gov/gene/64747 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010605 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA MKNK2 http://www.ncbi.nlm.nih.gov/gene/2872 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010606 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA MRPL49 http://www.ncbi.nlm.nih.gov/gene/740 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010607 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA MRPS16 http://www.ncbi.nlm.nih.gov/gene/51021 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010608 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA MTHFR http://www.ncbi.nlm.nih.gov/gene/4524 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010609 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA NDUFA8 http://www.ncbi.nlm.nih.gov/gene/4702 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010610 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA NET1 http://www.ncbi.nlm.nih.gov/gene/10276 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010611 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA NFE2L3 http://www.ncbi.nlm.nih.gov/gene/9603 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010612 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA NUDCD3 http://www.ncbi.nlm.nih.gov/gene/23386 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010613 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA NUP43 http://www.ncbi.nlm.nih.gov/gene/348995 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010614 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA NUP98 http://www.ncbi.nlm.nih.gov/gene/4928 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010615 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA OGT http://www.ncbi.nlm.nih.gov/gene/8473 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010616 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA PARP16 http://www.ncbi.nlm.nih.gov/gene/54956 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010617 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA PCBP1 http://www.ncbi.nlm.nih.gov/gene/5093 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010618 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA PCNX http://www.ncbi.nlm.nih.gov/gene/22990 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010619 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA PDCL http://www.ncbi.nlm.nih.gov/gene/5082 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010620 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA PHC3 http://www.ncbi.nlm.nih.gov/gene/80012 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010621 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA POLI http://www.ncbi.nlm.nih.gov/gene/11201 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010622 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA POLR1B http://www.ncbi.nlm.nih.gov/gene/84172 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010623 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA POLR2E http://www.ncbi.nlm.nih.gov/gene/5434 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010624 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA PON2 http://www.ncbi.nlm.nih.gov/gene/5445 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010625 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA POP4 http://www.ncbi.nlm.nih.gov/gene/10775 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010626 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA PRDM1 http://www.ncbi.nlm.nih.gov/gene/639 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010627 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA RASGRP3 http://www.ncbi.nlm.nih.gov/gene/25780 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010628 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA RBL2 http://www.ncbi.nlm.nih.gov/gene/5934 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010629 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA RBM43 http://www.ncbi.nlm.nih.gov/gene/375287 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010630 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA RC3H2 http://www.ncbi.nlm.nih.gov/gene/54542 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010631 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA ROD1 http://www.ncbi.nlm.nih.gov/gene/9991 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010632 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA RPP30 http://www.ncbi.nlm.nih.gov/gene/10556 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010633 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA RPS6KA1 http://www.ncbi.nlm.nih.gov/gene/6195 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010634 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA SCAMP1 http://www.ncbi.nlm.nih.gov/gene/9522 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010635 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA SCAMP2 http://www.ncbi.nlm.nih.gov/gene/10066 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010636 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA SERPINB9 http://www.ncbi.nlm.nih.gov/gene/5272 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010637 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA SF3A1 http://www.ncbi.nlm.nih.gov/gene/10291 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010638 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA SLC26A11 http://www.ncbi.nlm.nih.gov/gene/284129 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010639 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA SLC35F5 http://www.ncbi.nlm.nih.gov/gene/80255 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010640 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA SLC38A1 http://www.ncbi.nlm.nih.gov/gene/81539 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010641 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA SLC5A3 http://www.ncbi.nlm.nih.gov/gene/6526 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010642 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA SSH1 http://www.ncbi.nlm.nih.gov/gene/54434 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010643 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA STAM2 http://www.ncbi.nlm.nih.gov/gene/10254 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010644 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA STRN http://www.ncbi.nlm.nih.gov/gene/6801 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010645 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA SUMO3 http://www.ncbi.nlm.nih.gov/gene/285829 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010646 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA TAF2 http://www.ncbi.nlm.nih.gov/gene/6873 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010647 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA TBC1D23 http://www.ncbi.nlm.nih.gov/gene/55773 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010648 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA TCEB3 http://www.ncbi.nlm.nih.gov/gene/6924 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010649 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA TGIF2 http://www.ncbi.nlm.nih.gov/gene/60436 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010650 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA TMEM154 http://www.ncbi.nlm.nih.gov/gene/201799 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010651 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA TMEM173 http://www.ncbi.nlm.nih.gov/gene/340061 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010652 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA TOR1AIP1 http://www.ncbi.nlm.nih.gov/gene/26092 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010653 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA TRAK1 http://www.ncbi.nlm.nih.gov/gene/22906 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010654 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA TRAM2 http://www.ncbi.nlm.nih.gov/gene/9697 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010655 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA TUG1 http://www.ncbi.nlm.nih.gov/gene/55000 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010656 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA UBXN7 http://www.ncbi.nlm.nih.gov/gene/26043 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010657 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA VPS13C http://www.ncbi.nlm.nih.gov/gene/54832 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010658 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA WDFY3 http://www.ncbi.nlm.nih.gov/gene/23001 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010659 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA XPO4 http://www.ncbi.nlm.nih.gov/gene/64328 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010660 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA ZBTB37 http://www.ncbi.nlm.nih.gov/gene/84614 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010661 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA ZBTB43 http://www.ncbi.nlm.nih.gov/gene/23099 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010662 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA ZNF655 http://www.ncbi.nlm.nih.gov/gene/79027 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010663 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 BC-3 - Host mRNA ZNF689 http://www.ncbi.nlm.nih.gov/gene/115509 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010664 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-7(miR-K7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 Primary effusion lymphoma (PEL) cell lines - Host Protein MICB http://www.ncbi.nlm.nih.gov/gene/4277 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00010665 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-1 - Host mRNA AP1G1 http://www.ncbi.nlm.nih.gov/gene/164 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010666 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-1 - Host mRNA C14orf119 http://www.ncbi.nlm.nih.gov/gene/55017 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010667 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-1 - Host mRNA CARKD http://www.ncbi.nlm.nih.gov/gene/55739 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010668 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-1 - Host mRNA CBX8 http://www.ncbi.nlm.nih.gov/gene/57332 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010669 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-1 - Host mRNA CMTM7 http://www.ncbi.nlm.nih.gov/gene/112616 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010670 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-1 - Host mRNA CUX1 http://www.ncbi.nlm.nih.gov/gene/1523 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010671 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-1 - Host mRNA GLCCI1 http://www.ncbi.nlm.nih.gov/gene/113263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010672 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-1 - Host mRNA MIF http://www.ncbi.nlm.nih.gov/gene/4282 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010673 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-1 - Host mRNA NDRG1 http://www.ncbi.nlm.nih.gov/gene/10397 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010674 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-1 - Host mRNA PANK3 http://www.ncbi.nlm.nih.gov/gene/79646 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010675 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-1 - Host mRNA PPARGC1A http://www.ncbi.nlm.nih.gov/gene/10891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010676 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-1 - Host mRNA SFMBT2 http://www.ncbi.nlm.nih.gov/gene/57713 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010677 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-1 - Host mRNA SMNDC1 http://www.ncbi.nlm.nih.gov/gene/10285 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010678 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-1 - Host mRNA ZNF586 http://www.ncbi.nlm.nih.gov/gene/54807 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010679 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-3 - Host mRNA AP1G1 http://www.ncbi.nlm.nih.gov/gene/164 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010680 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-3 - Host mRNA C14orf119 http://www.ncbi.nlm.nih.gov/gene/55017 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010681 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-3 - Host mRNA CARKD http://www.ncbi.nlm.nih.gov/gene/55739 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010682 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-3 - Host mRNA CBX8 http://www.ncbi.nlm.nih.gov/gene/57332 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010683 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-3 - Host mRNA CMTM7 http://www.ncbi.nlm.nih.gov/gene/112616 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010684 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-3 - Host mRNA CUX1 http://www.ncbi.nlm.nih.gov/gene/1523 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010685 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-3 - Host mRNA GLCCI1 http://www.ncbi.nlm.nih.gov/gene/113263 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010686 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-3 - Host mRNA HCFC1 http://www.ncbi.nlm.nih.gov/gene/3054 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010687 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-3 - Host mRNA MARK2 http://www.ncbi.nlm.nih.gov/gene/2011 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010688 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-3 - Host mRNA MIF http://www.ncbi.nlm.nih.gov/gene/4282 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010689 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-3 - Host mRNA NDRG1 http://www.ncbi.nlm.nih.gov/gene/10397 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010690 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-3 - Host mRNA PANK3 http://www.ncbi.nlm.nih.gov/gene/79646 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010691 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-3 - Host mRNA PPARGC1A http://www.ncbi.nlm.nih.gov/gene/10891 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010692 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-3 - Host mRNA SFMBT2 http://www.ncbi.nlm.nih.gov/gene/57713 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010693 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-3 - Host mRNA SMNDC1 http://www.ncbi.nlm.nih.gov/gene/10285 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010694 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-3 - Host mRNA YWHAG http://www.ncbi.nlm.nih.gov/gene/7532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010695 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-3 - Host mRNA ZNF391 http://www.ncbi.nlm.nih.gov/gene/346157 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010696 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-8(miR-K8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002478 BC-3 - Host mRNA ZNF586 http://www.ncbi.nlm.nih.gov/gene/54807 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010697 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K12-9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 - - Host Protein BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VHID00010698 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K12-9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 - - Host Protein ZFYVE9 http://www.ncbi.nlm.nih.gov/gene/9372 - PAR-CLIP, HITS-CLIP, RIP-Chip. 23170179 Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP)(Table 2). Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays. VHID00010699 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K12-9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 - - Host mRNA BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VHID00010700 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K12-9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 - - Host mRNA IRAK1 http://www.ncbi.nlm.nih.gov/gene/3654 - Luciferase reporter assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA. VHID00010701 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 - - Host Protein BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00010702 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA ACSL3 http://www.ncbi.nlm.nih.gov/gene/2181 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010703 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA ADAR http://www.ncbi.nlm.nih.gov/gene/103 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010704 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA AGFG1 http://www.ncbi.nlm.nih.gov/gene/3267 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010705 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA AMMECR1 http://www.ncbi.nlm.nih.gov/gene/9949 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010706 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA ANKRD52 http://www.ncbi.nlm.nih.gov/gene/283373 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010707 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA APAF1 http://www.ncbi.nlm.nih.gov/gene/317 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010708 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA ARFGEF1 http://www.ncbi.nlm.nih.gov/gene/10565 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010709 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA ARL5A http://www.ncbi.nlm.nih.gov/gene/26225 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010710 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA ASB7 http://www.ncbi.nlm.nih.gov/gene/140460 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010711 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA ATF3 http://www.ncbi.nlm.nih.gov/gene/467 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010712 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA ATP6V1A http://www.ncbi.nlm.nih.gov/gene/523 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010713 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA BRAP http://www.ncbi.nlm.nih.gov/gene/8315 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010714 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA BRMS1L http://www.ncbi.nlm.nih.gov/gene/84312 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010715 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA BTBD3 http://www.ncbi.nlm.nih.gov/gene/22903 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010716 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA C10orf46 http://www.ncbi.nlm.nih.gov/gene/143384 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010717 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA C14orf138 http://www.ncbi.nlm.nih.gov/gene/79609 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010718 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA C19orf39 http://www.ncbi.nlm.nih.gov/gene/126074 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010719 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA C4orf32 http://www.ncbi.nlm.nih.gov/gene/132720 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010720 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA C8orf44 http://www.ncbi.nlm.nih.gov/gene/56260 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010721 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA C8orf82 http://www.ncbi.nlm.nih.gov/gene/414919 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010722 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA CBX1 http://www.ncbi.nlm.nih.gov/gene/10951 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010723 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA CBX5 http://www.ncbi.nlm.nih.gov/gene/23468 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010724 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA CD226 http://www.ncbi.nlm.nih.gov/gene/10666 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010725 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA CDCA5 http://www.ncbi.nlm.nih.gov/gene/113130 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010726 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA CEP97 http://www.ncbi.nlm.nih.gov/gene/79598 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010727 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA CHTF8 http://www.ncbi.nlm.nih.gov/gene/54921 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010728 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA CTDSPL2 http://www.ncbi.nlm.nih.gov/gene/51496 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010729 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA DRAM1 http://www.ncbi.nlm.nih.gov/gene/55332 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010730 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA EAPP http://www.ncbi.nlm.nih.gov/gene/55837 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010731 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA EIF2A http://www.ncbi.nlm.nih.gov/gene/83939 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010732 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA ELP2 http://www.ncbi.nlm.nih.gov/gene/55250 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010733 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA FAM13B http://www.ncbi.nlm.nih.gov/gene/51306 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010734 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA FAM3C http://www.ncbi.nlm.nih.gov/gene/10447 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010735 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA FBXO8 http://www.ncbi.nlm.nih.gov/gene/26269 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010736 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA FNDC3B http://www.ncbi.nlm.nih.gov/gene/64778 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010737 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA FRS2 http://www.ncbi.nlm.nih.gov/gene/10818 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010738 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA GABPB1 http://www.ncbi.nlm.nih.gov/gene/2553 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010739 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA GBAS http://www.ncbi.nlm.nih.gov/gene/2631 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010740 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA GCLC http://www.ncbi.nlm.nih.gov/gene/2729 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010741 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA GEN1 http://www.ncbi.nlm.nih.gov/gene/348654 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010742 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA GTF3C4 http://www.ncbi.nlm.nih.gov/gene/9329 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010743 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA HGF http://www.ncbi.nlm.nih.gov/gene/3082 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010744 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA HIC2 http://www.ncbi.nlm.nih.gov/gene/23119 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010745 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA HIST1H2BF http://www.ncbi.nlm.nih.gov/gene/8343 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010746 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA HIST1H3H http://www.ncbi.nlm.nih.gov/gene/8356 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010747 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA IQGAP3 http://www.ncbi.nlm.nih.gov/gene/128239 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010748 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA KBTBD8 http://www.ncbi.nlm.nih.gov/gene/84541 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010749 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA KCTD20 http://www.ncbi.nlm.nih.gov/gene/222658 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010750 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA KDM2A http://www.ncbi.nlm.nih.gov/gene/22992 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010751 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA KIAA1147 http://www.ncbi.nlm.nih.gov/gene/57189 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010752 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA KIF18A http://www.ncbi.nlm.nih.gov/gene/81930 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010753 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA KLHL15 http://www.ncbi.nlm.nih.gov/gene/80311 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010754 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA KPNA4 http://www.ncbi.nlm.nih.gov/gene/3840 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010755 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA LARP1 http://www.ncbi.nlm.nih.gov/gene/23367 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010756 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA MAK16 http://www.ncbi.nlm.nih.gov/gene/84549 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010757 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA MAPK1IP1L http://www.ncbi.nlm.nih.gov/gene/93487 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010758 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA MDFIC http://www.ncbi.nlm.nih.gov/gene/29969 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010759 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA MDM2 http://www.ncbi.nlm.nih.gov/gene/4193 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010760 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA MED4 http://www.ncbi.nlm.nih.gov/gene/29079 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010761 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA MLL http://www.ncbi.nlm.nih.gov/gene/4297 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010762 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA MLLT10 http://www.ncbi.nlm.nih.gov/gene/8028 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010763 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA MRPL35 http://www.ncbi.nlm.nih.gov/gene/51318 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010764 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA MTPN http://www.ncbi.nlm.nih.gov/gene/767558 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010765 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA NCOA2 http://www.ncbi.nlm.nih.gov/gene/10499 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010766 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA NIPA1 http://www.ncbi.nlm.nih.gov/gene/123606 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010767 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA NUFIP2 http://www.ncbi.nlm.nih.gov/gene/57532 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010768 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA OAZ2 http://www.ncbi.nlm.nih.gov/gene/4947 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010769 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA OTUD6B http://www.ncbi.nlm.nih.gov/gene/51633 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010770 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA OXNAD1 http://www.ncbi.nlm.nih.gov/gene/92106 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010771 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA PALM2-AKAP2 http://www.ncbi.nlm.nih.gov/gene/114299 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010772 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA PATZ1 http://www.ncbi.nlm.nih.gov/gene/23598 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010773 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA PDZD11 http://www.ncbi.nlm.nih.gov/gene/51248 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010774 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA PGRMC1 http://www.ncbi.nlm.nih.gov/gene/10857 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010775 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA PHC3 http://www.ncbi.nlm.nih.gov/gene/80012 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010776 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA PHF17 http://www.ncbi.nlm.nih.gov/gene/79960 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010777 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA PI15 http://www.ncbi.nlm.nih.gov/gene/51050 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010778 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA PICALM http://www.ncbi.nlm.nih.gov/gene/8301 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010779 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA PLDN http://www.ncbi.nlm.nih.gov/gene/26258 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010780 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA PPM1K http://www.ncbi.nlm.nih.gov/gene/152926 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010781 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA PSMF1 http://www.ncbi.nlm.nih.gov/gene/9491 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010782 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA PSMG2 http://www.ncbi.nlm.nih.gov/gene/56984 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010783 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA RAD21 http://www.ncbi.nlm.nih.gov/gene/5885 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010784 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA RBM12B http://www.ncbi.nlm.nih.gov/gene/389677 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010785 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA RFX7 http://www.ncbi.nlm.nih.gov/gene/64864 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010786 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA RNASEL http://www.ncbi.nlm.nih.gov/gene/6041 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010787 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA SEC62 http://www.ncbi.nlm.nih.gov/gene/7095 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010788 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA SEMA4D http://www.ncbi.nlm.nih.gov/gene/10507 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010789 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA SHISA5 http://www.ncbi.nlm.nih.gov/gene/51246 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010790 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA SLC35A4 http://www.ncbi.nlm.nih.gov/gene/113829 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010791 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA SLC38A1 http://www.ncbi.nlm.nih.gov/gene/81539 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010792 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA SLC38A2 http://www.ncbi.nlm.nih.gov/gene/54407 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010793 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA SMARCAD1 http://www.ncbi.nlm.nih.gov/gene/56916 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010794 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA SMC1A http://www.ncbi.nlm.nih.gov/gene/8243 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010795 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA SMG7 http://www.ncbi.nlm.nih.gov/gene/9887 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010796 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA SOCS1 http://www.ncbi.nlm.nih.gov/gene/8651 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010797 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA SPTLC2 http://www.ncbi.nlm.nih.gov/gene/9517 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010798 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA SSU72 http://www.ncbi.nlm.nih.gov/gene/29101 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010799 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA ST7 http://www.ncbi.nlm.nih.gov/gene/7982 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010800 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA STARD4 http://www.ncbi.nlm.nih.gov/gene/134429 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010801 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA STK16 http://www.ncbi.nlm.nih.gov/gene/8576 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010802 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA STK38 http://www.ncbi.nlm.nih.gov/gene/11329 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010803 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA SYNCRIP http://www.ncbi.nlm.nih.gov/gene/10492 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010804 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA TAF1B http://www.ncbi.nlm.nih.gov/gene/9014 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010805 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA TFDP2 http://www.ncbi.nlm.nih.gov/gene/7029 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010806 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA TIMM17A http://www.ncbi.nlm.nih.gov/gene/10440 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010807 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA TKT http://www.ncbi.nlm.nih.gov/gene/7086 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010808 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA TMED4 http://www.ncbi.nlm.nih.gov/gene/222068 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010809 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA TMEM138 http://www.ncbi.nlm.nih.gov/gene/51524 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010810 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA TMEM170A http://www.ncbi.nlm.nih.gov/gene/124491 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010811 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA TMPPE http://www.ncbi.nlm.nih.gov/gene/643853 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010812 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA TSG101 http://www.ncbi.nlm.nih.gov/gene/7251 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010813 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA TULP4 http://www.ncbi.nlm.nih.gov/gene/56995 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010814 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA TWISTNB http://www.ncbi.nlm.nih.gov/gene/221830 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010815 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA UBA6 http://www.ncbi.nlm.nih.gov/gene/55236 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010816 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA UBE2K http://www.ncbi.nlm.nih.gov/gene/3093 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010817 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA WDR7 http://www.ncbi.nlm.nih.gov/gene/23335 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010818 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA XPR1 http://www.ncbi.nlm.nih.gov/gene/9213 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010819 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA XRN1 http://www.ncbi.nlm.nih.gov/gene/54464 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010820 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA ZBTB7B http://www.ncbi.nlm.nih.gov/gene/51043 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010821 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA ZFYVE9 http://www.ncbi.nlm.nih.gov/gene/9372 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010822 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA ZNF498 http://www.ncbi.nlm.nih.gov/gene/221785 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010823 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BC-1 - Host mRNA ZNF543 http://www.ncbi.nlm.nih.gov/gene/125919 - PAR-CLIP. 22100165 Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs. VHID00010824 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 BJAB and BCBL-4 cells - Host Protein BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 Downregulation Immunoblotting and apoptosis, Luciferase assays, Microarrays, Sequence Analysis, miRNA expression. 19098914 The functional consequence of this downregulation for KSHV latency can be assessed by examining the effects of BCLAF1 modulation on viral replication. When latently infected cells are chemically induced to lytic KSHV growth, antagonism of miRs K5,9, 10a and 10b is associated with decreased virion production (Fig. 5a) and increased BCLAF1 expression (Fig. 5c). This suggests that BCLAF1 action acts to impair lytic viral replication. VHID00010825 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 Primary effusion lymphoma (PEL) cell lines - Host Protein BCLAF1 http://www.ncbi.nlm.nih.gov/gene/9774 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00010826 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K3(miR-K12-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 - - Host Protein CEBPB http://www.ncbi.nlm.nih.gov/gene/1051 - Transfection assays, KSHV miRNA target identification, ELISA, TLR inhibition assays, Immunoblots, IFA, Statistical analysis, KSHV purification and infection, RT-PCR, Flow cytometry. 20052801 Bioinformatics analysis identified KSHV miRNA binding sites for miR-K12-3 and miR-K12-7 within the 3'UTR of the basic region/leucine zipper motif transcription factor C/EBP, a known regulator of IL-6 and IL-10 transcriptional activation. VHID00010827 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K3(miR-K12-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002483 Primary effusion lymphoma (PEL) cell lines - Host Protein CEBPB http://www.ncbi.nlm.nih.gov/gene/1051 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00010828 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K7(miR-K12-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 - - Host Protein CEBPB http://www.ncbi.nlm.nih.gov/gene/1051 - Transfection assays, KSHV miRNA target identification, ELISA, TLR inhibition assays, Immunoblots, IFA, Statistical analysis, KSHV purification and infection, RT-PCR, Flow cytometry. 20052801 Bioinformatics analysis identified KSHV miRNA binding sites for miR-K12-3 and miR-K12-7 within the 3'UTR of the basic region/leucine zipper motif transcription factor C/EBP, a known regulator of IL-6 and IL-10 transcriptional activation. VHID00010829 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K7(miR-K12-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002479 Primary effusion lymphoma (PEL) cell lines - Host Protein CEBPB http://www.ncbi.nlm.nih.gov/gene/1051 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VHID00010830 Kaposi's sarcoma-associated herpesvirus(KSHV) Mus musculus Virus miRNA kshv-miR-K12-4-3p(miR-K12-4-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002192 - - Host Protein Gemin8 http://www.ncbi.nlm.nih.gov/gene/237221 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00010831 Kaposi's sarcoma-associated herpesvirus(KSHV) Mus musculus Virus miRNA kshv-miR-K12-4-5p(K12-4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 Lymphocytes - Host Protein Rb12 http://www.ncbi.nlm.nih.gov/gene/19651 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 miR-K12-1,-6, and -11 decrease of MAF(musculoaponeurotic fibrosarcoma oncogene homolog), K12-4-5p targeting retinoblastoma(Rb)-like protein 2(Rbl2). VHID00010832 Kaposi's sarcoma-associated herpesvirus(KSHV) Mus musculus Virus miRNA kshv-miR-K12-4-5p(miR-K12-4-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002191 - - Host Protein Rbl2 http://www.ncbi.nlm.nih.gov/gene/19651 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00010833 Kaposi's sarcoma-associated herpesvirus(KSHV) Mus musculus Virus miRNA kshv-mir-K12-1(miR-K12-10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 Lymphocytes - Host Protein Bclaf1(Bcl-2-associated transcription factor 1) http://www.ncbi.nlm.nih.gov/gene/72567 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 Indicate miR-K12-5, miR-K12-9 and miR-K12-10 repression of Bcl-2-associated transcription factor 1, an apoptosis-inducing factor. VHID00010834 Kaposi's sarcoma-associated herpesvirus(KSHV) Mus musculus Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 - - Host Protein Fos http://www.ncbi.nlm.nih.gov/gene/14281 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00010835 Kaposi's sarcoma-associated herpesvirus(KSHV) Mus musculus Virus miRNA kshv-mir-K12-11(miR-K12-11) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002474 B cells - Host Protein Jarid2 http://www.ncbi.nlm.nih.gov/gene/16468 Downregulation Luciferase reporter assay, Western blot analysis. 23185331 We demonstrate that retroviral-mediated gene transfer and hematopoietic progenitor cell transplantation into C57BL/6 mice leads to increased B-cell fractions in lymphoid organs, as well as to enhanced germinal center formation in both microRNA-expressing mouse cohorts. We furthermore identify Jarid2, a component of Polycomb repressive complex 2, as a novel validated target of miR-K12-11, and confirm its downregulation in miR-K12-11 as well as miR-155 expressing bone marrow cells. VHID00010836 Kaposi's sarcoma-associated herpesvirus(KSHV) Mus musculus Virus miRNA kshv-mir-K12-5(miR-K12-5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 Lymphocytes - Host Protein Bclaf1(Bcl-2-associated transcription factor 1) http://www.ncbi.nlm.nih.gov/gene/72567 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 Indicate miR-K12-5, miR-K12-9 and miR-K12-10 repression of Bcl-2-associated tran- scription factor 1, an apoptosis-inducing factor. VHID00010837 Kaposi's sarcoma-associated herpesvirus(KSHV) Mus musculus Virus miRNA kshv-mir-K12-9(miR-K12-9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 Lymphocytes - Host Protein Bclaf1(Bcl-2-associated transcription factor 1) http://www.ncbi.nlm.nih.gov/gene/72567 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 Indicate miR-K12-5, miR-K12-9 and miR-K12-10 repression of Bcl-2-associated tran- scription factor 1, an apoptosis-inducing factor. VHID00010838 Marek's disease virus 1(MDV-1) Gallus gallus Virus miRNA mdv1-miR-M4-5P http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003924 Ovary,fibroblast cell line. - Host mRNA CEBPE(C/EBP) http://www.ncbi.nlm.nih.gov/gene/396185 - RNA isolation and miRNA northern blotting analysis, Luciferase reporter assays. 20680360 Using luciferase reporter assays, We showed that mdv1-miR-M4-5P and miR-155 efficiently targeted a common set of 3' untranslated regions(3'UTR) of six cellular genes(GPM6B, RREB1, c-Myb, MAP3K7IP2, PU.1 and C/EBP). VHID00010839 Marek's disease virus 1(MDV-1) Gallus gallus Virus miRNA mdv1-miR-M4-5P http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003924 Ovary,fibroblast cell line. - Host mRNA GPM6B http://www.ncbi.nlm.nih.gov/gene/418632 - RNA isolation and miRNA northern blotting analysis, Luciferase reporter assays. 20680360 Using luciferase reporter assays, We showed that mdv1-miR-M4-5P and miR-155 efficiently targeted a common set of 3' untranslated regions(3'UTR) of six cellular genes(GPM6B, RREB1, c-Myb, MAP3K7IP2, PU.1 and C/EBP). VHID00010840 Marek's disease virus 1(MDV-1) Gallus gallus Virus miRNA mdv1-miR-M4-5P http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003924 Ovary,fibroblast cell line. - Host mRNA MYB(c-Myb) http://www.ncbi.nlm.nih.gov/gene/396244 - RNA isolation and miRNA northern blotting analysis, Luciferase reporter assays. 20680360 Using luciferase reporter assays, We showed that mdv1-miR-M4-5P and miR-155 efficiently targeted a common set of 3' untranslated regions(3'UTR) of six cellular genes(GPM6B, RREB1, c-Myb, MAP3K7IP2, PU.1 and C/EBP). VHID00010841 Marek's disease virus 1(MDV-1) Gallus gallus Virus miRNA mdv1-miR-M4-5P http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003924 Ovary,fibroblast cell line. - Host mRNA RREB1 http://www.ncbi.nlm.nih.gov/gene/395920 - RNA isolation and miRNA northern blotting analysis, Luciferase reporter assays. 20680360 Using luciferase reporter assays, We showed that mdv1-miR-M4-5P and miR-155 efficiently targeted a common set of 3' untranslated regions(3'UTR) of six cellular genes(GPM6B, RREB1, c-Myb, MAP3K7IP2, PU.1 and C/EBP). VHID00010842 Marek's disease virus 1(MDV-1) Gallus gallus Virus miRNA mdv1-miR-M4-5P http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003924 Ovary,fibroblast cell line. - Host mRNA SPI1(PU.1) http://www.ncbi.nlm.nih.gov/gene/6688 - RNA isolation and miRNA northern blotting analysis, Luciferase reporter assays. 20680360 Using luciferase reporter assays, We showed that mdv1-miR-M4-5P and miR-155 efficiently targeted a common set of 3' untranslated regions(3'UTR) of six cellular genes(GPM6B, RREB1, c-Myb, MAP3K7IP2, PU.1 and C/EBP). VHID00010843 Marek's disease virus 1(MDV-1) Gallus gallus Virus miRNA mdv1-miR-M4-5P http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003924 Ovary,fibroblast cell line. - Host mRNA TAB2(MAP3K7IP2) http://www.ncbi.nlm.nih.gov/gene/421622 - RNA isolation and miRNA northern blotting analysis, Luciferase reporter assays. 20680360 Using luciferase reporter assays, We showed that mdv1-miR-M4-5P and miR-155 efficiently targeted a common set of 3' untranslated regions(3'UTR) of six cellular genes(GPM6B, RREB1, c-Myb, MAP3K7IP2, PU.1 and C/EBP). VHID00010844 Marek's disease virus 1(MDV-1) Gallus gallus Virus miRNA mdv1-mir-M3(MDV1-miR-M3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005095 DF-1 cells - Host Protein SMAD2 http://www.ncbi.nlm.nih.gov/gene/395247 Downregulation Western blotting, and stem-loop qRT-PCR, semiquantitative RT-PCR, Immunohistochemistry (IHC), Cell viability assays, Dual luciferase reporter assay. 20962090 MDV1-miR-M3 suppressed cisplatin-induced apoptosis by directly downregulating expression at the protein but not the mRNA level of Smad2, a critical component in the transforming growth factor beta signal pathway. VHID00010845 Marek's disease virus 1(MDV-1) Gallus gallus Virus miRNA mdv1-mir-M3(miR-M3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005095 - - Host Protein SMAD2 http://www.ncbi.nlm.nih.gov/gene/395247 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00010846 Marek's disease virus 1(MDV-1) Gallus gallus Virus miRNA mdv1-mir-M4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005096 - - Host mRNA BCL2L13 http://www.ncbi.nlm.nih.gov/gene/418163 Downregulation Western blot analysis. 18945769 Thus, the reporter assays demonstrated that targets such as PU.1, CEBPE, HIVEP2, BCL2L13, and PDCD6 can be negatively regulated by both gga-miR-155 and MDV-1-miR-M4. VHID00010847 Marek's disease virus 1(MDV-1) Gallus gallus Virus miRNA mdv1-mir-M4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005096 - - Host mRNA CEBPE(C/EBP) # - MicroRNA microarray, Northern blotting, Western blot analysis, indicator reporter assay, Luciferase reporter assays, quantitative real-time PCR analysis. 18945769 Thus, the reporter assays demonstrated that targets such as PU.1, CEBPE, HIVEP2, BCL2L13, and PDCD6 can be negatively regulated by both gga-miR-155 and MDV-1-miR-M4. VHID00010848 Marek's disease virus 1(MDV-1) Gallus gallus Virus miRNA mdv1-mir-M4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005096 - - Host mRNA HIVEP2 http://www.ncbi.nlm.nih.gov/gene/421672 - MicroRNA microarray, Northern blotting, Western blot analysis, indicator reporter assay, Luciferase reporter assays, quantitative real-time PCR analysis. 18945769 Thus, the reporter assays demonstrated that targets such as PU.1, CEBPE, HIVEP2, BCL2L13, and PDCD6 can be negatively regulated by both gga-miR-155 and MDV-1-miR-M4. VHID00010849 Marek's disease virus 1(MDV-1) Gallus gallus Virus miRNA mdv1-mir-M4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005096 - - Host mRNA PDCD6 http://www.ncbi.nlm.nih.gov/gene/420988 Downregulation Western blot analysis. 18945769 Thus, the reporter assays demonstrated that targets such as PU.1, CEBPE, HIVEP2, BCL2L13, and PDCD6 can be negatively regulated by both gga-miR-155 and MDV-1-miR-M4. VHID00010850 Marek's disease virus 1(MDV-1) Gallus gallus Virus miRNA mdv1-mir-M4 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005096 - - Host mRNA SPI1(PU.1) http://www.ncbi.nlm.nih.gov/gene/395879 Downregulation Western blot analysis. 18945769 Thus, the reporter assays demonstrated that targets such as PU.1, CEBPE, HIVEP2, BCL2L13, and PDCD6 can be negatively regulated by both gga-miR-155 and MDV-1-miR-M4. VHID00010851 Marek's disease virus 1(MDV-1) Gallus gallus Virus miRNA mdv1-mir-M4(miR-M4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005096 - - Host Protein C-MYB http://www.ncbi.nlm.nih.gov/gene/396244 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00010852 Marek's disease virus 1(MDV-1) Gallus gallus Virus miRNA mdv1-mir-M4(miR-M4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005096 - - Host Protein CEBPE(C/EBP) http://www.ncbi.nlm.nih.gov/gene/396185 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00010853 Marek's disease virus 1(MDV-1) Gallus gallus Virus miRNA mdv1-mir-M4(miR-M4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005096 - - Host Protein GPM6B http://www.ncbi.nlm.nih.gov/gene/418632 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00010854 Marek's disease virus 1(MDV-1) Gallus gallus Virus miRNA mdv1-mir-M4(miR-M4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005096 - - Host Protein MAP3K7(MAP3K7I) http://www.ncbi.nlm.nih.gov/gene/421622 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00010855 Marek's disease virus 1(MDV-1) Gallus gallus Virus miRNA mdv1-mir-M4(miR-M4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005096 - - Host Protein RREB1 http://www.ncbi.nlm.nih.gov/gene/395920 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00010856 Marek's disease virus 1(MDV-1) Gallus gallus Virus miRNA mdv1-mir-M4(miR-M4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005096 - - Host Protein SPI1(PU.1) http://www.ncbi.nlm.nih.gov/gene/395879 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00010857 Merkel cell polyomavirus(MCPyV) Homo sapiens Virus miRNA mcv-miR-M1(MCV-miR-M1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010647 Merkel cell carcinomas - Host Protein Pik3cd(PIK3CD) http://www.ncbi.nlm.nih.gov/gene/18707 Downregulation Predicted. 21907614 MCV-miR-M1 has several potentially relevant predicted cellular targets, as revealed by in silico analysis. Two genes, PIK3CD and PSME3, are especially interesting because they are potentially involved in mediating the host immune response against MCPyV. VHID00010858 Merkel cell polyomavirus(MCPyV) Homo sapiens Virus miRNA mcv-miR-M1(MCV-miR-M1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010647 Merkel cell carcinomas - Host Protein Psme3(PSME3) http://www.ncbi.nlm.nih.gov/gene/19192 Downregulation Predicted. 21907614 MCV-miR-M1 has several potentially relevant predicted cellular targets, as revealed by in silico analysis. Two genes, PIK3CD and PSME3, are especially interesting because they are potentially involved in mediating the host immune response against MCPyV. VHID00010859 Murine cytomegalovirus(MCMV) Mus musculus Virus miRNA mcmv-mir-M23-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006253 - - Host Protein Cxcl16(CXCL16) http://www.ncbi.nlm.nih.gov/gene/66102 Downregulation Quantitative PCR analysis of viral transcripts, Dual luciferase experiments, Northern blot analysis. 20976200 Using 2'-O-methylated antisense oligonucleotide, we confirmed that the CXCL16 reporter regulation by miR-M23-2 could be inhibited in a sequence specific manner. VHID00010860 Murine cytomegalovirus(MCMV) Mus musculus Virus miRNA mcmv-mir-M23-2(miR-M23-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006253 - - Host Protein Cxcl16(CXCL16) http://www.ncbi.nlm.nih.gov/gene/66102 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VHID00010861 Package lentivirus(PLV) Homo sapiens Virus miRNA pLV-THM-miR-338-3p(miR-338-3p) # SW-620 cells Upregulation Host Protein SMO http://www.ncbi.nlm.nih.gov/gene/6608 Downregulation real-time reverse transcriptase polymerase chain reaction and Western blotting. 23599646 miR-338-3p could suppress CRC growth by inhibiting SMO protein expression.The recombinant viral vector encoding the pre-miR-338-3p or miR-338-3p-inhibitor and the two packaging plasmids psPAX2 and pMD2.G were cotransfected into human embryonic kidney 293T cells to package lentiVirus. VHID00010862 Rhesus lymphocryptovirus(rLCV) Macaca mulatta Virus miRNA rlcv-mir-rL1-8(miR-rL1-8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003744 rLCV-infected rhesus macaquerLCLs - Host Protein NFKB1 http://www.ncbi.nlm.nih.gov/gene/710324 Downregulation luciferase reporter assays, photoactivatable cross-linking and immunoprecipitation(PAR-CLIP), and deep sequencing and qRT-PCR. 24257599 These data demonstrate that miR-rL1-8 can functionally substitute for miRBART5 and that miR-BART5 and miR-BART16 negatively regulate NFKB signaling by directly targeting the LMP1 3'UTR. VHID00010863 West Nile virus(WNV) Anopheles gambiae Virus miRNA kun-miR-1 # Aedes albopictus C6/36 cells - Host mRNA GATA4 http://www.ncbi.nlm.nih.gov/gene/100329087 Upregulation PCR, Northern blot analysis, Cloning approach. 22080551 Using cloning and bioinformatics approaches, we identified the cellular GATA4 mRNA as a target for KUN-miR-1. VHID00010864 White spot syndrome virus(WSSV) Shrimp Virus miRNA WSSV-miR-N24 # shrimp hemocytes - Host Protein caspase 8 # - Microarray analysis,Northern blotting. 24352447 In this study, the viral miRNAs from white spot syndrome virus (WSSV) were characterized in shrimp in vivo. As revealed by miRNA microarray analysis and Northern blotting, the expression of viral miRNAs was tissue specific in vivo. The results indicated that the viral miRNA WSSV-miR-N24 could target the shrimp caspase 8 gene, and this miRNA further repressed the apoptosis of shrimp hemocytes in vivo. . VVID00010865 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 - - Virus Protein UL114 http://www.ncbi.nlm.nih.gov/gene/3077539 Downregulation Luciferase assay, Computational predictions, Western blotting, Real-time PCR analysis. 19656885 Here we demonstrate that miR-UL112 also targets the UL114 gene, and we present evidence that the reduction of UL114 by miR-UL112 reduces its activity as uracil DNA glycosylase but only minimally affects virus growth. VVID00010866 Autographa californica nucleopolyhedrovirus(AcMNPV) Autographa californica Virus miRNA AcMNPV-miR-1 # Sf9 cells infected with AcMNPV (10 PFU/cell) - Virus mRNA odv-e25(ODV-E25) http://www.ncbi.nlm.nih.gov/gene/1488709 Downregulation luciferase reporter assays, photoactivatable cross-linking and immunoprecipitation(PAR-CLIP), and deep sequencing and qRT-PCR. 24027316 Here we report the identification and characterization of an miRNA encoded by Autographa californica nucleopolyhedrovirus. The identified miRNA, AcMNPV-miR-1, perfectly matched a segment in the coding sequence of the viral gene ODV-E25 and downregulated ODV-E25 mRNA expression, which likely resulted in a reduction of infectious budded virions and accelerated the formation of occlusion-derived virions. . VVID00010867 BK virus(BKV) Homo sapiens Virus miRNA bkv-mir-B1(miR-B1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0009981 - - Virus Protein LT-Ag # Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, assays of acute infection and CTL reactivity in vivo, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VVID00010868 Barley stripe mosaic virus(BSMV) Triticum aestivum Virus miRNA tae-MIR159a(pri-tae-miR159a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006170 - - Virus Protein Tamyb3(taMyb3) http://www.ncbi.nlm.nih.gov/gene/780678 - - 23665893 The results of the histological observation also supported these phenotype changes. Interestingly, vsiRNAs were also involved in the interactions between wheat and Pst through the tae-miR159-mediated regulation of taMyb3 expression. Moreover, these results also supported the speculation that vsiRNAs were generated from the same sites of pri-tae-miR159a. These studies indicated that vsiRNAs from miRNAs generating sites of pri-tae-miR159a based on the BSMV system play positive roles in the wheat response to Pst through the regulation of taMyb3 expression. VVID00010869 Epstein-Barr virus(EBV) Homo sapiens Virus SnoRNA v-snoRNA1 # - - Virus Protein BALF5 http://www.ncbi.nlm.nih.gov/gene/3783681 - Fluorescent in situ hybridization, Co-Immunoprecipitation, Computational prediction of target sites in rRNAs, Quantitative real-time PCR. 19680535 Apotential target site of v-snoRNA1(24pp) was identified within the 3'-UTR of BALF5 mRNA which encodes the viral DNA polymerase.The viral DNA polymerase.BALF5 was identified as a potential target for vsnoRNA1(24pp). Taken together, these experiments strengthen the crucial function of v-snoRNA1 in EBV infection. VVID00010870 Epstein-Barr virus(EBV) Homo sapiens Virus SnoRNA vsnoRNA124pp # latency III EBV infection cells - Virus Protein BALF5 http://www.ncbi.nlm.nih.gov/gene/3783681 Downregulation Northern blot analysis,Co-Immunoprecipitation,Quantitative real-time PCR. 19680535 A potential target site of v-snoRNA124pp?was identified within the 3'-UTR of BALF5 mRNA which encodes the viral DNA polymerase. VVID00010871 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-3p(miR-BART1-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003390 293T cells - Virus Protein BHRF1 http://www.ncbi.nlm.nih.gov/gene/3783706 Downregulation Western blot analysis, PAR-CLIP, qRT-PCR for RISC-associated BHRF1 mRNAs,Luciferase reporter assays. 24257599 In addition to miR-BART10, we observed significant inhibition of the EBV BHRF1 3'UTR reporter in the presence of miR-BART1. miR-BART1-3p and its rLCV homolog, miR-rL1-6-3p, have seed matches (nt 2 to 8) to the EBV and rLCV BHRF1 3'UTRs, al-though the positions of the seed match sites and the miRNA inhibition are not conserved. . VVID00010872 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(BART1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 - - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Downregulation Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 In some cases, the target viral mRNA is regulated by multiple miRNAs. Several of the EBV BART miRNAs from a single genomic cluster(BART1-5p, BART3-5p, BART16, and BART17-5p) work together to down-regulate production of the EBV latency membrane protein 1(LMP1). VVID00010873 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART1-5p(miR-BART1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 - - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, assays of acute infection and CTL reactivity in vivo, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VVID00010874 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-3p(miR-BART17-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003716 Akata (KC207813),Raji (NC_007605.1),MutuI(KC207814) BL cells (51), C666 nasopharyngeal epithelial carci-noma(NPC) cells (EF103558), and other NPC isolates - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Downregulation luciferase reporter assays, photoactivatable cross-linking and immunoprecipitation(PAR-CLIP), and deep sequencing and qRT-PCR. 24257599 For the four EBV miRNAs inhibiting the LMP1 3' UTR reporter (Fig. 6A), we identified putative seed match sites for miRBART5-5p and miR-BART17-3p but not miR-BART3 or miRBART16 (Fig. 6C). VVID00010875 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(BART17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 - - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Downregulation Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 In some cases, the target viral mRNA is regulated by multiple miRNAs. Several of the EBV BART miRNAs from a single genomic cluster(BART1-5p, BART3-5p, BART16, and BART17-5p) work together to down-regulate production of the EBV latency membrane protein 1(LMP1). VVID00010876 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(miR-BART17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003715 - - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, assays of acute infection and CTL reactivity in vivo, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VVID00010877 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART17-5p(miR-BART17-5p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004990 NPC C666-1 cell line - Virus mRNA LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Downregulation TUNEL Assay, Western Blotting, EBER in Situ Hybridization (ISH), Immunohistochemical (IHC) Staining of LMP1, Northern Blotting, Luciferase Reporter Assay, Quantitative RT-PCR (QRT-PCR). 17911266 EBV-encoded BART miRNAs target the 3 UTR of the LMP1 gene and negatively regulate LMP1 protein expression. Four miRNAs (BART3-5p, 16, 17-5p, and 1-5p) were examined that LMP1 gene was a target of BART miRNAs. VVID00010878 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART3-5p(BART3-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 - - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Downregulation Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 In some cases, the target viral mRNA is regulated by multiple miRNAs. Several of the EBV BART miRNAs from a single genomic cluster(BART1-5p, BART3-5p, BART16, and BART17-5p) work together to down-regulate production of the EBV latency membrane protein 1(LMP1). VVID00010879 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART5-5p(miR-BART5-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003413 EBV B95-8 LCLs and type III BL cells - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Downregulation PAR-CLIP . 24257599 Examination of the EBV LMP1 3'UTR by PAR-CLIP revealed four RISC-associated regions in Akata-LCLd3, two of which contained binding sites for miR-BART5-5p(7mer1A seed match) and the cellular miR-17/20/106 family ). VVID00010880 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART5-5p(miRBART5-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003413 Akata (KC207813),Raji (NC_007605.1),MutuI(KC207814) BL cells (51), C666 nasopharyngeal epithelial carci-noma(NPC) cells (EF103558), and other NPC isolates - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Downregulation luciferase reporter assays, photoactivatable cross-linking and immunoprecipitation(PAR-CLIP), and deep sequencing and qRT-PCR. 24257599 For the four EBV miRNAs inhibiting the LMP1 3=UTR reporter (Fig. 6A), we identified putative seed match sites for miRBART5-5p and miR-BART17-3p but not miR-BART3 or miRBART16 (Fig. 6C). VVID00010881 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART1(miR-BART1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001067 B cells - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 EBV miR-BART1, -16, and -17 reduce the expression of EBV LMP1 to prevent its overexpression.LMP1 without a ligand drives proliferation of EBV-infected B cells by signaling within the B cells similar to the signaling of the cellular CD40 receptor. VVID00010882 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART1(miR-BART1-5p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001067 - - Virus mRNA LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VVID00010883 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART1(mir-BART1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001067 B cell lymphomagenesis - Virus mRNA LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Downregulation Western Blotting, Northern Blotting, Luciferase Reporter Assay. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VVID00010884 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART1-5p(miR-BART1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000999 NPC C666-1 cell line - Virus mRNA LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Downregulation TUNEL Assay, Western Blotting, EBER in Situ Hybridization (ISH), Immunohistochemical (IHC) Staining of LMP1, Northern Blotting, Luciferase Reporter Assay, Quantitative RT-PCR (QRT-PCR). 17911266 EBV-encoded BART miRNAs target the 3 UTR of the LMP1 gene and negatively regulate LMP1 protein expression. Four miRNAs (BART3-5p, 16, 17-5p, and 1-5p) were examined that LMP1 gene was a target of BART miRNAs. VVID00010885 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(miR-BART10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 293T cells - Virus Protein BHRF1 http://www.ncbi.nlm.nih.gov/gene/3783706 Downregulation Western blot analysis, PAR-CLIP, qRT-PCR for RISC-associated BHRF1 mRNAs,Luciferase reporter assays. 24257599 In addition to miR-BART10, we observed significant inhibition of the EBV BHRF1 3'UTR reporter in the presence of miR-BART1. miR-BART1-3p and its rLCV homolog, miR-rL1-6-3p, have seed matches (nt 2 to 8) to the EBV and rLCV BHRF1 3'UTRs, al-though the positions of the seed match sites and the miRNA inhibition are not conserved. . VVID00010886 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART10(mir-BART10) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003732 B cell lymphomagenesis - Virus mRNA BHRF1 http://www.ncbi.nlm.nih.gov/gene/3783706 - Western Blotting, Northern Blotting, Luciferase Reporter Assay. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VVID00010887 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 MRC5 and HEK293T cells - Virus mRNA BRLF1 http://www.ncbi.nlm.nih.gov/gene/3783727 - Predicted. 18378902 EBV(-herpesvirus) miR-BHRF1-3 and miR-BART15 likely target BZLF1 and BRLF1, which share their 3 UTR. VVID00010888 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART15 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004988 MRC5 and HEK293T cells - Virus mRNA BZLF1 http://www.ncbi.nlm.nih.gov/gene/3783744 - Predicted. 18378902 EBV(-herpesvirus) miR-BHRF1-3 and miR-BART15 likely target BZLF1 and BRLF1, which share their 3 UTR. VVID00010889 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(BART16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 - - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Downregulation Cloning and quantitative PCR, subtractive hybridization of RNA transcripts (SHORT), soft agar growth assay. 20719877 In some cases, the target viral mRNA is regulated by multiple miRNAs. Several of the EBV BART miRNAs from a single genomic cluster(BART1-5p, BART3-5p, BART16, and BART17-5p) work together to down-regulate production of the EBV latency membrane protein 1(LMP1). VVID00010890 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(miR-BART16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 - - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, assays of acute infection and CTL reactivity in vivo, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VVID00010891 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(miR-BART16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 - - Virus mRNA LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VVID00010892 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(miR-BART16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 EBV B95-8 LCLs and type III BL cells - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Downregulation Western blot analysis, PAR-CLIP, qRT-PCR for RISC-associated BHRF1 mRNAs,Luciferase reporter assays. 24257599 miR-BART16 also inhibited pLSG-LMP1nt671 but not pLSG-LMP1nt692, indicating that miR-BART16 targets the 5'region of the LMP1 3'UTR. VVID00010893 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART16(miR-BART16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004989 NPC C666-1 cell line - Virus mRNA LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Downregulation TUNEL Assay, Western Blotting, EBER in Situ Hybridization (ISH), Immunohistochemical (IHC) Staining of LMP1, Northern Blotting, Luciferase Reporter Assay, Quantitative RT-PCR (QRT-PCR). 17911266 EBV-encoded BART miRNAs target the 3 UTR of the LMP1 gene and negatively regulate LMP1 protein expression. Four miRNAs (BART3-5p, 16, 17-5p, and 1-5p) were examined that LMP1 gene was a target of BART miRNAs. VVID00010894 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART17(miR-BART17-5p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004990 - - Virus mRNA LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VVID00010895 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART17(mir-BART17) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004990 B cell lymphomagenesis - Virus mRNA LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - Western Blotting, Northern Blotting, Luciferase Reporter Assay. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VVID00010896 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART19(mir-BART19) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004992 B cell lymphomagenesis - Virus mRNA LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - Western Blotting, Northern Blotting, Luciferase Reporter Assay. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VVID00010897 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART2(miR-BART2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001068 - - Virus Protein BALF5 http://www.ncbi.nlm.nih.gov/gene/3783681 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, assays of acute infection and CTL reactivity in vivo, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VVID00010898 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART2(miR-BART2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001068 - - Virus mRNA BALF5 http://www.ncbi.nlm.nih.gov/gene/3783681 Downregulation - 19158788 Destroyuser interface control1, called miR-BART2, was found to lie antisense to the EBV DNA polymerase gene BALF5 and was proposed to inhibit DNA polymerase expression by inducing cleavage of the cognate mRNA. VVID00010899 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART2(miR-BART2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001068 HeLa cells - Virus mRNA BALF5 http://www.ncbi.nlm.nih.gov/gene/3783681 Downregulation EBV load measurement, Transfections and luciferase assays, northern blot analysis and probe labelling, RNA Isolation, Ago2-mediated cleavage assays, Immunoprecipitation analysis. 18073197 Here we show that the EBV-encoded miRNA miR-BART2 down-regulates the viral DNA polymerase BALF5. MiR-BART2 guides cleavage within the 3'-untranslated region (3'UTR) of BALF5 by virtue of its complete complementarity to its target. . VVID00010900 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART2(miR-BART2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001068 latency III EBV infection cells - Virus mRNA BALF5 http://www.ncbi.nlm.nih.gov/gene/3783681 Downregulation Generation of monoclonal antibodies against BALF5 and Ago2,Immunoprecipitation analysis,Transfections and luciferase assays,RNA Isolation, northern blot analysis and probe labelling,Ago2-mediated cleavage assays,EBV load measurement. 18073197 MiR-BART2 guides cleavage within the 3'-untranslated region (3'UTR) of BALF5 by virtue of its complete complementarity to its target.?. VVID00010901 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART2(mir-BART2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001068 B cell lymphomagenesis - Virus mRNA BLAF5 http://www.ncbi.nlm.nih.gov/gene/3783681 Downregulation Western Blotting, Northern Blotting, Luciferase Reporter Assay. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VVID00010902 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART20(miR-BART20) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004993 LCLs - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - luciferase reporter assays, photoactivatable cross-linking and immunoprecipitation(PAR-CLIP), and deep sequencing and qRT-PCR. 24257599 Using luciferase reporter assays and by performing PAR-CLIP analysis of LCLs latently infected with EBV or rLCV, we show here that five EBV BART miRNAs (miR-BART3, miR-BART5, miR-BART16, miRBART17, and miR-BART20) and at least four rLCV BART miRNA homologs (miR-rL1-5, miR-rL1-8, miR-rL1-16, and miR-rL1-23) target LMP1 3'UTRs. VVID00010903 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART21(miR-BART21) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010627 rLCV-infected rhesus macaquerLCLs - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Downregulation luciferase reporter assays, photoactivatable cross-linking and immunoprecipitation(PAR-CLIP), and deep sequencing and qRT-PCR. 24257599 Intriguingly, ectopic expression of miR-BART21 also inhibited luciferase expression from the rLCV LMP1 3'UTR reporter , consistent with our PAR-CLIP results demonstrating that the miR-BART21 homolog (miR-rL1-23) binds the rLMP1 mRNA. VVID00010904 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(miR-BART22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 - - Virus Protein LMP2A(LMP-2a) http://www.ncbi.nlm.nih.gov/gene/3783751 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, assays of acute infection and CTL reactivity in vivo, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VVID00010905 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(miR-BART22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 Nasopharyngeal epithelial tissues - Virus mRNA LMP2A http://www.ncbi.nlm.nih.gov/gene/3783751 - Western Blot Analysis, Immunohistochemical Staining of LMP2A, Target Prediction, Quantitative Reverse Transcription-Polymerase Chain Reaction, Northern Blot Analysis, Luciferase Reporter Assay. 19881953 More importantly, we determined that the EBV latent membrane protein 2A (LMP2A) is the putative target of miR-BART22. LMP2A is a potent immunogenic viral antigen that is recognized by the cytotoxic T cells; down-modulation of LMP2A expression by miR-BART22 may permit escape of EBV-infected cells from host immune surveillance. Taken together, we demonstrated that two newly identified EBV-encoded miRNA are highly expressed in NPC. Our findings emphasize the role of miR-BART22 in modulating LMP2A expression, which may facilitate NPC carcinogenesis by evading the host immune response. VVID00010906 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART22(mir-BART22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010628 B cell lymphomagenesis - Virus mRNA LMP2A http://www.ncbi.nlm.nih.gov/gene/3783751 Downregulation Western Blotting, Northern Blotting, Luciferase Reporter Assay. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VVID00010907 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3(miR-BART3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003725 LCLs - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - luciferase reporter assays, photoactivatable cross-linking and immunoprecipitation(PAR-CLIP), and deep sequencing and qRT-PCR. 24257599 Using luciferase reporter assays and by performing PAR-CLIP analysis of LCLs latently infected with EBV or rLCV, we show here that five EBV BART miRNAs (miR-BART3, miR-BART5, miR-BART16, miRBART17, and miR-BART20) and at least four rLCV BART miRNA homologs (miR-rL1-5, miR-rL1-8, miR-rL1-16, and miR-rL1-23) target LMP1 3'UTRs. VVID00010908 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART3-5p(miR-BART3-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003410 NPC C666-1 cell line - Virus mRNA LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Downregulation TUNEL Assay, Western Blotting, EBER in Situ Hybridization (ISH), Immunohistochemical (IHC) Staining of LMP1, Northern Blotting, Luciferase Reporter Assay, Quantitative RT-PCR (QRT-PCR). 17911266 EBV-encoded BART miRNAs target the 3 UTR of the LMP1 gene and negatively regulate LMP1 protein expression. Four miRNAs (BART3-5p, 16, 17-5p, and 1-5p) were examined that LMP1 gene was a target of BART miRNAs. VVID00010909 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART5(mir-BART5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003727 B cell lymphomagenesis - Virus mRNA LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Downregulation Western Blotting, Northern Blotting, Luciferase Reporter Assay. 23342366 EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes. VVID00010910 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART6(miR-BART6-5p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003728 C666-1 cell - Virus mRNA EBNA2 http://www.ncbi.nlm.nih.gov/gene/17494192 Downregulation Transfections of the miR-BART6-5p Antagomir, Northern Blotting, miRISC Loading Assay,EMSA assays. 20716523 We found that miR-BART6-5p RNAs suppress the EBNA2 viral oncogene required for transition from immunologically less responsive type I and type II latency to the more immunoreactive type III latency as well as Zta and Rta viral proteins essential for lytic replication, revealing the regulatory function of miR-BART6 in EBV infection and latency. VVID00010911 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9( BART9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 SNK6 and SNT16 cells Upregulation Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Upregulation Immunoblotting, RT-real time PCR for EBV mRNAs, Validation of miRNA microarray, MiRNA microarray analysis and validation, Cell proliferation functional assay. 22102884 Our data indicate that BART9 is involved in NKTCL proliferation, and one of its mechanisms of action appears to be regulating LMP-1 levels. VVID00010912 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BART9(miR-BART9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003731 NK/T-cell lymphoma cell line SNK6 - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Upregulation RNA Extraction and Quantitative Reverse Transcription PCR (QRT-PCR),Expression of BHRF1 and Northern Blot,AGO2 Co-Immunoprecipitation,Induction of Viral Lytic Cycle in NPC Cell Lines,Plasmid Constructs,In Vitro Processing Assay. 22102884 Ranakrishnan et al. showed that miR-BART9 from the NK/T-cell lymphoma cell line SNK6 could increase viral LMP1 expression. This might be the key mechanism of EBV to promote cell growth. VVID00010913 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-3 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001066 MRC5 and HEK293T cells - Virus mRNA BRLF1 http://www.ncbi.nlm.nih.gov/gene/3783727 - Predicted. 18378902 EBV(-herpesvirus) miR-BHRF1-3 and miR-BART15 likely target BZLF1 and BRLF1, which share their 3 UTR. VVID00010914 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-mir-BHRF1-3 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001066 MRC5 and HEK293T cells - Virus mRNA BZLF1 http://www.ncbi.nlm.nih.gov/gene/3783744 - Predicted. 18378902 EBV(-herpesvirus) miR-BHRF1-3 and miR-BART15 likely target BZLF1 and BRLF1, which share their 3 UTR. VVID00010915 Hepatitis B virus(HBV) Mus musculus Virus ShRNA U6 shRNA 5 # - - Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 Downregulation Northern blot hybridization, Expression and processing of shRNA, shRNA expression cassettes and synthetic siRNA, Assessment of in vivo efficacy of anti-HBV shRNA constructs, Quantitative PCR, Statistical analysis. 16337206 Effective inhibition of HBV replication in vivo by anti-HBx short hairpin RNAs. Two shRNAs (shRNA 5 and shRNA 6) showed knockdown of HBV markers by 80-100% in transfected hepatocytes and also in a murine hydrodynamic injection model of HBV replication. VVID00010916 Hepatitis B virus(HBV) Mus musculus Virus ShRNA U6 shRNA 6 # - - Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 Downregulation Northern blot hybridization, Expression and processing of shRNA, shRNA expression cassettes and synthetic siRNA, Assessment of in vivo efficacy of anti-HBV shRNA constructs, Quantitative PCR, Statistical analysis. 16337206 Effective inhibition of HBV replication in vivo by anti-HBx short hairpin RNAs. Two shRNAs (shRNA 5 and shRNA 6) showed knockdown of HBV markers by 80-100% in transfected hepatocytes and also in a murine hydrodynamic injection model of HBV replication. VVID00010917 Herpes B virus(BV) Homo sapiens Virus miRNA hbv-mir-B20(miRNA 20) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0011557 BV-infected cells - Virus Protein ICP34.5 # - - 19144716 BV miRNA 20 is antisense relative to a sequence that, in HSV, would encode ICP34.5 and be the only antisense target for this miRNA (20). ICP34.5 is an important HSV neurovirulence factor. VVID00010918 Herpes B virus(BV) Homo sapiens Virus miRNA hbv-mir-B2RC(miRNA 2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0011555 BV-infected cells - Virus Protein UL30 # Downregulation Northern blot hybridization, statistical analysis. 19144716 BV miRNA 2 is antisense relative to a sequence k100 nt upstream of the initiating AUG of the UL30 gene, which encodes the catalytic subunit of the DNA polymerase. Therefore, miRNA 2 may regulate the expression of UL30 in the same way that the EBV-encoded miRNA miR-BART2 regulates the expression of the EBV DNA polymerase. VVID00010919 Herpes simplex virus 1(HSV-1) Homo sapiens Virus miRNA hsv1-miR-H2-3p (miR-H2-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0008399 neurons - Virus mRNA ICP0 # Downregulation Predicted. 19158788 One of these miRNAs, miR-H2-3p, lies antisense to the viral immediate early gene ICP0 and has been shown to downregulate ICP0 protein expression. VVID00010920 Herpes simplex virus 1(HSV-1) Homo sapiens Virus miRNA hsv1-miR-H2-3p(miR-H2-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0008399 - - Virus Protein ICP0 # Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VVID00010921 Herpes simplex virus 1(HSV-1) Homo sapiens Virus miRNA hsv1-mir-H2(miR-H2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008937 neuronal cells - Virus mRNA ICP0 # Downregulation Luciferase assays. 23536669 Analysis of mRNA and protein expression, as well as assays mapping viral miRNA binding sites in infected cells, showed that endogenous HSV-1 miR-H2 binds to viral ICP0 mRNA and inhibits its expression,while endogenous miR-H4 inhibits the expression of the viral ICP34.5 gene. In contrast, no viral mRNA target for miR-H3 could be detected, even though miR-H3, like miR-H4, is perfectly complementary to ICP34.5 mRNA. VVID00010922 Herpes simplex virus 1(HSV-1) Homo sapiens Virus miRNA hsv1-mir-H2(miR-H2-3p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008937 - - Virus mRNA ICP0 # - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VVID00010923 Herpes simplex virus 1(HSV-1) Homo sapiens Virus miRNA hsv1-mir-H2(miR-H2-3p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008937 - Downregulation Virus Protein ICP0 # Downregulation Standard techniques, Northern and Western blot analyses, Stem-loop RT-PCR methods, RNA harvested for RT-PCR analysis. 18596690 We show that LAT functions as a primary microRNA (miRNA) precursor that encodes four distinct miRNAs in HSV-1 infected cells. One of these miRNAs, miR-H2-3p, is transcribed antisense to ICP0, a viral immediate-early transcriptional activator thought to play a key role in productive HSV-1 replication and reactivation from latency3. miR-H2-3p is indeed able to reduce ICP0 protein expression, but does not significantly affect ICP0 mRNA levels. VVID00010924 Herpes simplex virus 1(HSV-1) Homo sapiens Virus miRNA hsv1-mir-H3(miR-H3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008938 neurons - Virus mRNA ICP34.5 # Downregulation Predicted. 19158788 In addition to miR-H2-3p lying antisense to ICP0, HSV-1 miR-H3 and miR-H4 also lie antisense to the gene encoding the pathogenicity factor ICP34.5 and, based on genetic data, were proposed to inhibit ICP34.5 expression in latently infected neurons. VVID00010925 Herpes simplex virus 1(HSV-1) Homo sapiens Virus miRNA hsv1-mir-H4(miR-H4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008939 neuronal cells - Virus mRNA ICP34.5 # Downregulation Luciferase assays. 23536669 Analysis of mRNA and protein expression, as well as assays mapping viral miRNA binding sites in infected cells, showed that endogenous HSV-1 miR-H2 binds to viral ICP0 mRNA and inhibits its expression,while endogenous miR-H4 inhibits the expression of the viral ICP34.5 gene. In contrast, no viral mRNA target for miR-H3 could be detected, even though miR-H3, like miR-H4, is perfectly complementary to ICP34.5 mRNA. VVID00010926 Herpes simplex virus 1(HSV-1) Homo sapiens Virus miRNA hsv1-mir-H4(miR-H4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008939 neurons - Virus mRNA ICP34.5 # Downregulation Predicted. 19158788 In addition to miR-H2-3p lying antisense to ICP0, HSV-1 miR-H3 and miR-H4 also lie antisense to the gene encoding the pathogenicity factor ICP34.5 and, based on genetic data, were proposed to inhibit ICP34.5 expression in latently infected neurons. VVID00010927 Herpes simplex virus 1(HSV-1) Homo sapiens Virus miRNA hsv1-mir-H6(miR-H6) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008941 - - Virus Protein ICP4 # Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VVID00010928 Herpes simplex virus 1(HSV-1) Homo sapiens Virus miRNA hsv1-mir-H6(miR-H6) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008941 - - Virus mRNA ICP5 # - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VVID00010929 Herpes simplex virus 1(HSV-1) Homo sapiens Virus miRNA hsv1-mir-H6(miR-H6) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008941 - Downregulation Virus Protein ICP4 # Downregulation Standard techniques, Northern and Western blot analyses, Stem-loop RT-PCR methods, RNA harvested for RT-PCR analysis. 18596690 We also identified a fifth HSV-1 miRNA in latently infected trigeminal ganglia, miR-H6, which derives from a previously unknown transcript distinct from LAT. miR-H6 displays extended seed complementarity to the mRNA encoding a second HSV-1 transcription factor, ICP4, and inhibits expression of ICP4, which is required for expression of most HSV-1 genes during productiveinfection. VVID00010930 Herpes simplex virus 2(HSV-2) Homo sapiens Virus miRNA hsv2-mir-H2(miR-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010694 - - Virus Protein ICP34.5 # Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VVID00010931 Herpes simplex virus 2(HSV-2) Homo sapiens Virus miRNA hsv2-mir-H3(miR-3) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010692 - - Virus Protein ICP0 # Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VVID00010932 Herpes simplex virus 2(HSV-2) Homo sapiens Virus miRNA hsv2-mir-H3(miR-I) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010692 - - Virus mRNA ICP34.5 # Downregulation - 19158788 miR-I reduces ICP34.5 protein and mRNA expression when overexpressed in HSV-2 infected cells in culture. VVID00010933 Herpes simplex virus 2(HSV-2) Homo sapiens Virus miRNA miR-I # - - Virus Protein ICP34.5 # Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VVID00010934 Herpes simplex virus 2(HSV-2) Homo sapiens Virus miRNA miR-I # Neurons - Virus Protein ICP34.5 # Downregulation Real-time PCR, transfection, Plasmids, Northern blotting, Oligonucleotide probes and RNA oligonucleotides, and dual luciferase assay. 19019961 We further show that, similar to miR-I, miR-II is able to efficiently silence the expression of ICP34.5, a key viral neurovirulence factor, and that miR-III is able to silence the expression of ICP0, a key viral transactivator. All these data suggest that LAT sequences likely contribute to HSV latency and reactivation through tight control of these LAT-encoded miRNAs and their viral targets. VVID00010935 Herpes simplex virus 2(HSV-2) Homo sapiens Virus miRNA miR-II # Neurons - Virus Protein ICP34.5 # Downregulation Real-time PCR, transfection, Plasmids, Northern blotting, Oligonucleotide probes and RNA oligonucleotides, and dual luciferase assay. 19019961 We further show that, similar to miR-I, miR-II is able to efficiently silence the expression of ICP34.5, a key viral neurovirulence factor, and that miR-III is able to silence the expression of ICP0, a key viral transactivator. All these data suggest that LAT sequences likely contribute to HSV latency and reactivation through tight control of these LAT-encoded miRNAs and their viral targets. VVID00010936 Herpes simplex virus 2(HSV-2) Homo sapiens Virus miRNA miR-III # Neurons - Virus Protein ICP0 # Downregulation Real-time PCR, Northern blotting, Oligonucleotide probes and RNA oligonucleotides, and dual luciferase assay. 19019961 We further show that, similar to miR-I, miR-II is able to efficiently silence the expression of ICP34.5, a key viral neurovirulence factor, and that miR-III is able to silence the expression of ICP0, a key viral transactivator. All these data suggest that LAT sequences likely contribute to HSV latency and reactivation through tight control of these LAT-encoded miRNAs and their viral targets. VVID00010937 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 - - Virus mRNA UL123(IE72/IE1) http://www.ncbi.nlm.nih.gov/gene/3077513 Downregulation - 19158788 As noted above, miR-UL112-1 has also been reported to downregulate the viral IE72/IE1 immediate early protein in hCMV-infected cells (Table 1), thus providing the first example of a viral miRNA that targets both viral and cellular mRNAs. VVID00010938 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112(hcmv-miR-UL112-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 MRC5 and HEK293T cells - Virus mRNA UL123(IE1) http://www.ncbi.nlm.nih.gov/gene/3077513 Downregulation Luciferase report,Transfection experiment. 18378902 HCMV IE1 protein synthesis is suppressed by by miR-UL-112-1. VVID00010939 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112(miR-UL112-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 - - Virus Protein IE1 # Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, assays of acute infection and CTL reactivity in vivo, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VVID00010940 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112(miR-UL112-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 - - Virus Protein IE72 # Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, assays of acute infection and CTL reactivity in vivo, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VVID00010941 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112(miR-UL112-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 - - Virus Protein UL114 http://www.ncbi.nlm.nih.gov/gene/3077539 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, assays of acute infection and CTL reactivity in vivo, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VVID00010942 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112(miR-UL112-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 - - Virus mRNA IE1 # Downregulation - 22568714 Table2. Human CMV miRNAs and their functions. Inhibits HCMV IE1 gene expression, and acts as an immune response inhibitor to help viral replication.Inhibits HCMV IE1 gene expression, and acts as an immune response inhibitor to help viral replication Specifically downregulates MICB expression during viral infection, leading to decreased binding of NKG2D and reduced killing by NK cells. VVID00010943 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112(miR-UL112-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 - - Virus mRNA IE72 http://www.ncbi.nlm.nih.gov/gene/5495302 - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VVID00010944 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112(miR-UL112-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 - - Virus mRNA UL112 http://www.ncbi.nlm.nih.gov/gene/3077495 Downregulation - 22568714 Table2. Human CMV miRNAs and their functions. Inhibits HCMV IE1 gene expression, and acts as an immune response inhibitor to help viral replication.Inhibits HCMV IE1gene expression, and acts as an immune response inhibitor to help viral replication Specifically downregulates MICB expression during viral infection, leading to decreased binding of NKG2D and reduced killing by NK cells. VVID00010945 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112(miR-UL112-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 - - Virus mRNA UL112 http://www.ncbi.nlm.nih.gov/gene/3077495 Downregulation Luciferase reporters. 17983268 The potential target sites were screened using luciferase reporters that contain the HCMV 3'UTRs in co-transfection assays with miR-UL112-1. Three of the 14 HCMV miRNA targets were validated, including the major immediate early gene encoding IE72 (UL123, IE1), UL112/113, and UL120/121. . VVID00010946 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112(miR-UL112-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 - - Virus mRNA UL114 http://www.ncbi.nlm.nih.gov/gene/3077539 Downregulation - 22568714 Table2. Human CMV miRNAs and their functions. Inhibits HCMV IE1 gene expression, and acts as an immune response inhibitor to help viral replication.Inhibits HCMV IE1gene expression, and acts as an immune response inhibitor to help viral replication Specifically downregulates MICB expression during viral infection, leading to decreased binding of NKG2D and reduced killing by NK cells. VVID00010947 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112(miR-UL112-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 - - Virus mRNA UL117 http://www.ncbi.nlm.nih.gov/gene/3077511 Downregulation - 22568714 Table2. Human CMV miRNAs and their functions. Inhibits HCMV IE1 gene expression, and acts as an immune response inhibitor to help viral replication.Inhibits HCMV IE1gene expression, and acts as an immune response inhibitor to help viral replication Specifically downregulates MICB expression during viral infection, leading to decreased binding of NKG2D and reduced killing by NK cells. VVID00010948 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112(miR-UL112-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 - - Virus mRNA UL123(IE1) http://www.ncbi.nlm.nih.gov/gene/3077513 Downregulation Luciferase reporters. 17983268 Bioinformatics analysis of the known HCMV mRNA 3' untranslated regions (UTRs) revealed 14 potential viral transcripts that were predicted to contain functional target sites for miR-UL112-1. Three of the 14 HCMV miRNA targets were validated, including the major immediate early gene encoding IE72 (UL123, IE1), UL112/113, and UL120/121. miR-UL112-1 Negatively Regulates Expression from Vectors Containing the HCMV 39UTRs of IE72, UL112/113, and UL120/121. VVID00010949 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112(miR-UL112-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 Normal human dermal fibroblast(NHDF) cells(Clonetics) and human U373 cells - Virus mRNA UL113 # - Luciferase reporters. 17983268 The potential target sites were screened using luciferase reporters that contain the HCMV 3'UTRs in co-transfection assays with miR-UL112-1. Three of the 14 HCMV miRNA targets were validated, including the major immediate early gene encoding IE72 (UL123, IE1), UL112/113, and UL120/121. . VVID00010950 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112(miR-UL112-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 Normal human dermal fibroblast(NHDF) cells(Clonetics) and human U373 cells - Virus mRNA UL120 http://www.ncbi.nlm.nih.gov/gene/3077520 - Luciferase reporters. 17983268 The potential target sites were screened using luciferase reporters that contain the HCMV 3'UTRs in co-transfection assays with miR-UL112-1. Three of the 14 HCMV miRNA targets were validated, including the major immediate early gene encoding IE72 (UL123, IE1), UL112/113, and UL120/121. . VVID00010951 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112(miR-UL112-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 Normal human dermal fibroblast(NHDF) cells(Clonetics) and human U373 cells - Virus mRNA UL121 http://www.ncbi.nlm.nih.gov/gene/3077529 - Luciferase reporters. 17983268 The potential target sites were screened using luciferase reporters that contain the HCMV 3'UTRs in co-transfection assays with miR-UL112-1. Three of the 14 HCMV miRNA targets were validated, including the major immediate early gene encoding IE72 (UL123, IE1), UL112/113, and UL120/121. . VVID00010952 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL112(miR-UL112-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001680 - - Virus mRNA IE72 http://www.ncbi.nlm.nih.gov/gene/5495302 Downregulation Luciferase assay, Western blot analysis, miRNA expression cassettes, Sequence analysis, miR-US25-1 KO virus, RT-PCR analysis, RNA induced silencing complex immunoprecipitation(RISC-IP) techniques. 20585629 Previously,we demonstrated that the HCMV encoded miRNA, miR-UL112-1, targets a number of the virus's own genes, including the immediate early transactivator IE72 which is essential for driving acute replication of HCMV. VVID00010953 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-UL36(hcmv-miR-UL36) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001679 HEK293 cells - Virus Protein UL138 http://www.ncbi.nlm.nih.gov/gene/3077420 Downregulation Luciferase reporter assays,Western blot,hybrid PCR. 23938381 Fifteen putative targets of hcmv-miR-UL36 were identified using hybrid PCR, one being the HCMV UL138 gene that has previously been identified as a novel latency-associated determinant of HCMV infection.Down-regulation of UL138 expression by hcmv-miR-UL36 was validated using luciferase reporter assays and Western blot analysis in HEK293 cells. VVID00010954 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US5-1(miR-US5-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001682 - - Virus mRNA US7 http://www.ncbi.nlm.nih.gov/gene/3077535 - - 22568714 Table2. Human CMV miRNAs and their functions. Inhibits HCMV IE1 gene expression, and acts as an immune response inhibitor to help viral replication.Inhibits HCMV IE2gene expression, and acts as an immune response inhibitor to help viral replication Speciflly downregulates MICB expression during viral infection, leading to decreased binding of NKG2D and reduced killing by NK cells. VVID00010955 Human cytomegalovirus(HCMV) Homo sapiens Virus miRNA hcmv-mir-US5-2(miR-US5-2) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001683 - - Virus mRNA US7 http://www.ncbi.nlm.nih.gov/gene/3077535 - - 22568714 Table2. Human CMV miRNAs and their functions. Inhibits HCMV IE1 gene expression, and acts as an immune response inhibitor to help viral replication.Inhibits HCMV IE3gene expression, and acts as an immune response inhibitor to help viral replication Speciflly downregulates MICB expression during viral infection, leading to decreased binding of NKG2D and reduced killing by NK cells. VVID00010956 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-miR-N367 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006104 CD4+ T lymphocytes cells - Virus mRNA nef(Nef) http://www.ncbi.nlm.nih.gov/gene/156110 Downregulation Luciferase assay. 22936931 Table 1 includes the RNAi pathway related gene products that are targeted by HIV-1 microRNAs. List of published HIV-1 microRNAs and their target HIV-1 and cellular gene products.The target interactions of HIV-1 microRNAs with its mRNA seem to function as viral genome regulators. VVID00010957 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-miR-TAR-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006017 CD4+ T lymphocytes - Virus mRNA TARDBP(TAR) # Downregulation Luciferase assays. 22936931 Table 1 includes the RNAi pathway related gene products that are targeted by HIV-1 microRNAs. List of published HIV-1 microRNAs and their target HIV-1 and cellular gene products.The target interactions of HIV-1 microRNAs with its mRNA seem to function as viral genome regulators. VVID00010958 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-miR-TAR-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006017 CD4+ T lymphocytes cells - Virus mRNA RITS # Downregulation Luciferase assay. 22936931 Table 1 includes the RNAi pathway related gene products that are targeted by HIV-1 microRNAs. List of published HIV-1 microRNAs and their target HIV-1 and cellular gene products.The target interactions of HIV-1 microRNAs with its mRNA seem to function as viral genome regulators. VVID00010959 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-miR-TAR-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006016 CD4+ T lymphocytes - Virus mRNA LTR http://www.ncbi.nlm.nih.gov/gene/8303958 Downregulation Luciferase assay. 22936931 Table 1 includes the RNAi pathway related gene products that are targeted by HIV-1 microRNAs. List of published HIV-1 microRNAs and their target HIV-1 and cellular gene products.The target interactions of HIV-1 microRNAs with its mRNA seem to function as viral genome regulators. VVID00010960 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-miR-TAR-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006016 CD4+ T lymphocytes - Virus mRNA TAR # Downregulation Luciferase assay. 22936931 Table 1 includes the RNAi pathway related gene products that are targeted by HIV-1 microRNAs. List of published HIV-1 microRNAs and their target HIV-1 and cellular gene products.The target interactions of HIV-1 microRNAs with its mRNA seem to function as viral genome regulators. VVID00010961 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-miR-TAR-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006016 CD4+ T lymphocytes cells - Virus mRNA RITS # Downregulation Luciferase assay. 22936931 Table 1 includes the RNAi pathway related gene products that are targeted by HIV-1 microRNAs. List of published HIV-1 microRNAs and their target HIV-1 and cellular gene products.The target interactions of HIV-1 microRNAs with its mRNA seem to function as viral genome regulators. VVID00010962 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-H1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006106 Human blood mononuclear cells - Virus Protein vpr http://www.ncbi.nlm.nih.gov/gene/155807 Downregulation FACS analysis, trypan-blue dye exclusion method, microarray analysis, Real-Time PCR, Bioinformatic analysis. 19082544 Further, hiv1-mir-H1 had the capacity to downregulate expression of cellular miR149 gene recognized to target Vpr gene encoded by HIV-1. Based upon these findings, we propose an "Epigenomic Pathway" through which hiv1-mir-H1 induced AATF gene knockdown within human mononuclear cells initiates their apoptosis. VVID00010963 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-H1(miR-H1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006106 CD4+ T cells - Virus Protein LTR http://www.ncbi.nlm.nih.gov/gene/8303958 - - 22833062 Table1 cellular microRNAs interacting with HIV and putative HIV-encoded microRNAs and their proposed role. Cleaveage of apoptosis antagonizing transcription factor and degradation of gene products. VVID00010964 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-N367(miR-N367) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006104 - - Virus Protein LTR # Downregulation Northern blot analysis, Immunoblotting, Luc assay. 15722536 The miR-N367 could reduce HIV-1 LTR promoter activity through the negative responsive element of the U3 region in the 5'-LTR. Therefore, nef miRNA produced in HIV-1-infected cells may downregulate HIV-1 transcription through both a post-transcriptional pathway and a transcriptional neo-pathway. VVID00010965 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-N367(miR-N367) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006104 - - Virus Protein nef(Nef) http://www.ncbi.nlm.nih.gov/gene/156110 Downregulation Confocal laser microscopy analysis, Northern blot analysis, antigen capture assay, Luc assay, Flow cytometric analysis, Semi-quantitative RT-PCR analysis. 15601474 These data suggest that nef/U3 miRNAs produced in HIV-1-infected cells may suppress both Nef function and HIV-1 virulence through the RNAi pathway.Nef-derived miRNAs are produced in HIV-1 persistently infected cells and nef short hairpin RNA (shRNA) that corresponded to a predicted nef miRNA (~25 nt, miR-N367) can block HIV-1 Nef expression in vitro and the suppression by shRNA/miR-N367 would be related with low viremia in an LTNP . VVID00010966 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-N367(miR-N367) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006104 - - Virus Protein nef(Nef) http://www.ncbi.nlm.nih.gov/gene/156110 Downregulation Northern blot analysis, Immunoblotting, Luc assay. 15722536 In the study reported here, nef-derived miRNAs in HIV-1-infected and nef transduced cells were identified, and showed that HIV-1 transcription was suppressed by nef-expressing miRNA, miR-N367, in human T cells. VVID00010967 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR(TAR) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 - - Virus Protein tat http://www.ncbi.nlm.nih.gov/gene/155871 - - 11725049 Short basic peptides that competed full-length tat from complexes with TAR RNA also inhibited tat stimulation of transcription, whereas short basic peptide unable to bind TAR or compete tat from complexes were also unable to inhibit tat stimulation of transcription. These data confirm that active HIV-1 tat must first interact with TAR RNA via basic amino acid residues in order to stimulate transcription of downstream sequences. VVID00010968 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR(TAR) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 - - Virus Protein tat http://www.ncbi.nlm.nih.gov/gene/155871 - Annealing two short synthetic oligoribonucleotides. 8450529 The binding site for tat on TAR RNA was analysed by preparing a series of model RNA substrates carrying site-specific functional group modifications. The test RNAs were prepared by annealing two short synthetic oligoribonucleotides to form a duplex structure with a U-rich bulge and flanking sequences identical to TAR RNA. We conclude that tat forms multiple specific hydrogen bonds to a series of dispersed sites displayed in the major groove of the TAR RNA molecule. These include the N3-H of U23, the N7 of G26, the N7 of A26 and the phosphate between A22 and U23. VVID00010969 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR(TAR) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 - - Virus Protein tat http://www.ncbi.nlm.nih.gov/gene/155871 - Dual-label competition filter binding assay. 8450553 The binding site for tat protein on TAR RNA has been defined in quantitative terms using an extensive series of mutations. The relative dissociation constants for the mutant TAR RNAs were measured using a dual-label competition filter binding assay in which 35S-labelled wild-type TAR RNA(K1) was competed against 3H-labelled mutant TAR RNA(K2). VVID00010970 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR(TAR) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 - - Virus Protein tat http://www.ncbi.nlm.nih.gov/gene/155871 - Electron paramagnetic resonance (EPR) spectroscopy. 12475232 Electron paramagnetic resonance (EPR) spectroscopy was utilized to investigate the correlation between RNA structure and RNA internal dynamics in complexes of HIV-1 TAR RNA with small molecules. TAR RNAs containing single nitroxide spin-labels in the 2'-position of U23, U25, U38, or U40 were incubated with compounds known to inhibit TAR-Tat complex formation. VVID00010971 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR(TAR) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 - - Virus Protein tat http://www.ncbi.nlm.nih.gov/gene/155871 - NMR experiments, Amide derivative of arginine experiments. 9518494 Formation of a specific complex between the HIV Tat protein and the small RNA element TAR is critical for activation of viral transcription. A model complex for this interaction composed of HIV-2 TAR and the amide derivative of arginine has been developed to study how Tat and TAR interact specifically. . VVID00010972 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR(TAR) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 - - Virus Protein tat http://www.ncbi.nlm.nih.gov/gene/155871 - Proteolytic digestions, MALDI-TOF mass spectrometric analysis. 9485463 The Human Immunodeficiency Virus type 1 Tat protein interacts specifically with a U-rich bulge within an RNA stem-loop known as the trans-activation responsive region(TAR) that occurs in all viral transcripts. We have identified the cross-linked amino acid as Arg55 in the basic region of the Tat peptide by use of a combination of proteolytic digestions and MALDI-TOF mass spectrometric analysis. VVID00010973 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR(TAR) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 - - Virus Protein tat http://www.ncbi.nlm.nih.gov/gene/155871 - Ribonuclease protection technique, Mutagenic analysis of TAR. 1868081 Substantial evidence indicates that HIV-1 trans-activation by tat protein is mediated through the TAR RNA element. VVID00010974 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR(TAR) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 - - Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - Interproton distance and dihedral angle constraint, Hydrogen bonding, NMR spectroscop, Structure determinatio. 8918800 Efficient transcription from the human immunodeficiency virus(HIV) promoter depends on binding of the viral regulatory protein Tat to a cis-acting RNA regulatory element, TAR. Tat binds at a trinucleotide bulge located near the apex of the TAR stem-loop structure. VVID00010975 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR(TAR) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 - - Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - Nuclear magnetic resonance (NMR) spectroscopy. 1621097 The messenger RNAs of human immunodeficiency virus-1 (HIV-1) have an RNA hairpin structure, TAR, at their 5' ends that contains a six-nucleotide loop and a three-nucleotide bulge. The conformations of TAR RNA and of TAR with an arginine analog specifically bound at the binding site for the viral protein, Tat, were characterized by nuclear magnetic resonance(NMR) spectroscopy. VVID00010976 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR(TAR) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 T-cell lines (CEM, Jurkat, Molt4, Hut78, H9), HIV-1 infected T-cell lines (ACH2, J1.1) - Virus Protein Dicer # Downregulation biotin-labeled TAR. 17663774 This shows that Dicer, expressed in CD4+ T-cells and HIV-1 infected T-cells, binds to the HIV-1 TAR structure and implies that the TAR element present in HIV-1 . VVID00010977 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR(TAR) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 T-cell lines (CEM, Jurkat, Molt4, Hut78, H9), HIV-1 infected T-cell lines (ACH2, J1.1) - Virus Protein LTR # Downregulation RNase protection assay, Luciferase assays, Chromatin immunoprecipitation, Western blot. 17663774 We tested the ability of TAR derived miRNA to downregulate viral gene expression through the use of a plasmid containing the luciferase gene under control of the HIV-1 LTR. VVID00010978 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR(TAR) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 T-cell lines (CEM, Jurkat, Molt4, Hut78, H9), HIV-1 infected T-cell lines (ACH2, J1.1) - Virus Protein RISC # Downregulation Biotin labeled, Dicer cleavage, RNase protection assay, Chromatin immunoprecipitation, competition assays, Luciferase assays, Western blot. 17663774 A miRNA generated from one side of the HIV TAR stemloop, such as the small RNA detected by the TAR 5' probe in our RPA assay, will possess significant similarity to the complementary strand of the TAR element. Production of this viral miRNA may down regulate viral gene expression by targeting the RISC or RITS complexes to viral RNA transcripts that contain the TAR element. VVID00010979 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR(TAR) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 T-cell lines (CEM, Jurkat, Molt4, Hut78, H9), HIV-1 infected T-cell lines (ACH2, J1.1) - Virus Protein RITS # Downregulation Biotin labeled, Dicer cleavage, RNase protection assay, Chromatin immunoprecipitation, competition assays, Luciferase assays, Western blot. 17663774 A miRNA generated from one side of the HIV TAR stemloop, such as the small RNA detected by the TAR 5' probe in our RPA assay, will possess significant similarity to the complementary strand of the TAR element. Production of this viral miRNA may down regulate viral gene expression by targeting the RISC or RITS complexes to viral RNA transcripts that contain the TAR element. VVID00010980 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR-3p http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 - - Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - Electrophoretic mobility shift assay, Cell culture and luciferase activity assays, Northern blot analyses, RNase protection assays, Production of virus stocks and infection, Primer extension experiments, In vitro Dicer RNase assays. 18299284 HIV-1 TAR element is the target of the viral transactivating Tat protein, which is expressed during the course of HIV-1 infection and known to act at the RNA level to enhance viral gene expression by >100-fold (29). We thus examined whether Tat could shield TAR RNA and prevent its processing by Dicer. VVID00010981 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hiv1-mir-TAR-5p http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007073 - - Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - Electrophoretic mobility shift assay, Cell culture and luciferase activity assays, Northern blot analyses, RNase protection assays, Production of virus stocks and infection, Primer extension experiments, In vitro Dicer RNase assays. 18299284 HIV-1 TAR element is the target of the viral transactivating Tat protein, which is expressed during the course of HIV-1 infection and known to act at the RNA level to enhance viral gene expression by >100-fold (29). We thus examined whether Tat could shield TAR RNA and prevent its processing by Dicer. VVID00010982 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hsv1-mir-LAT http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006105 MRC5 and HEK293T cells - Virus mRNA ICP0 # - Predicted. 18378902 Table2 Whole genome ranks for predicted miRNA-IE target pairs in four herpesviruse.HSV-1 miR-LAT likely targets ICP0. VVID00010983 Human immunodeficiency virus 1(HIV-1) Homo sapiens Virus miRNA hsv1-mir-LAT(miR-LAT) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006105 MRC5 and HEK293T cells - Virus mRNA Gamma34.5(the HSV-1 neurovirulence factor ) # - Predicted. 18378902 The HSV-1 neurovirulence factor Gamma34.5, whose RNA contains an octamer seed binding site for miR-LAT. VVID00010984 Human papillomavirus(HPV) Homo sapiens Virus ShRNA HPV16 E6A # SiHa cells - Virus mRNA E6 http://www.ncbi.nlm.nih.gov/gene/13887830 Downregulation Reporter assays,RIP-Chip,Immunoprecipitation. 16681752 HPV16E6A shRNA was found to be the most efficient in our study, which caused the reduction of HPV16 E6 mRNA to 10% in SiHa cells but did not reduce HPV18 E6 mRNA expression in HeLa cells. VVID00010985 John Cunningham virus(JCV) Homo sapiens Virus miRNA jcv-mir-J1(miR-J1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0009980 - - Virus Protein LT-Ag # Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, assays of acute infection and CTL reactivity in vivo, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VVID00010986 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus LncRNA PAN # - Upregulation Virus Protein ORF57 http://www.ncbi.nlm.nih.gov/gene/4961525 - Luciferase assays. 23077296 We report that PABPC1 forms a complex with the Kaposi's sarcoma-associated herpesvirus(KSHV) ORF57 protein, which allows ORF57 to interact with a 9-nucleotide(nt) core element of KSHV polyadenylated nuclear(PAN) RNA, a viral long noncoding RNA(LncRNA), and increase PAN stability.these data indicate that PABPC1 is an important cellular target of viral ORF57 to directly upregulate PAN accumulation during viral lytic infection, and the ability of host PABPC1 to disrupt ORF57 expression is a strategic host counterbalancing mechanism. VVID00010987 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus LncRNA PAN # 293L cells - Virus Protein ORF50(K-Rta) http://www.ncbi.nlm.nih.gov/gene/4961526 Upregulation Chromatin Immunoprecipitation (ChIP), Real-time PCR, RNA Cross-Linking Immunoprecipitation (RNA CLIP), Chromatin Isolation by RNA Purification (ChIRP), RNA chromatin immunoprecipitation assays, Southern blot analysis. 22589717 Expression of PAN RNA intrans in BAC36CRDPAN containing cells resulted in an increase in K-Rta expression, however K-Rta over expression failed to rescue BAC36CRDPAN, suggesting that PAN RNA plays a wider role in virus replication. To investigate the role of PAN RNA in the activation of K-Rta expression, we demonstrate that PAN RNA physically interacts with the ORF50 promoter. . VVID00010988 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-5(miR-K12-5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 - - Virus Protein ORF50 http://www.ncbi.nlm.nih.gov/gene/4961526 Downregulation ChIP and KSHV genome array, Quantitative RT-PCR, MeDIP, Luciferase assay. 20071580 However, BAC36 miR consistently expressed elevated levels of viral lytic genes, including the immediate-early transcriptional activator Rta (ORF50). At least one KSHV microRNA (miR-K12-5) was capable of suppressing ORF50 mRNA, but poor seed sequence alignments suggest that these targets may be indirect. VVID00010989 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-6-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 MRC5 and HEK293T cells - Virus mRNA Zta # - Predicted. 18378902 KSHV(gamma-herpesvirus) Rta(ORF 50) and Zta(ORF K8) are homologues of EBV BRLF1 and BZLF1, respectively, although functionally BZLF1 seems to correspond more to the Rta. The 3' UTR shared by Zta and Rta is likely targeted by the KSHV miR-K10-6-3p. VVID00010990 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-7-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015217 - - Virus Protein KSHV ORF50 http://www.ncbi.nlm.nih.gov/gene/4961526 Downregulation RNA extraction and quantitative real-time PCR, Western blot analysis, Dual-luciferase reporter assay, PCR analysis of progeny virus. 21283761 miR-K12-7-5p Encoded by Kaposi's Sarcoma-Associated Herpesvirus Stabilizes the Latent State by Targeting Viral ORF50/RTA .The inhibition of RTA expression by miR-K12-7 was further confirmed in the latently KSHV-infected 293/Bac36 cell line through transient transfection of miR-K12-7 expression plasmid or specific inhibitor of miR-K12-7-5p, respectively. The transient transfection of miR-K12-7 into 293/Bac36 cells reduced RTA expression and the expression of the downstream early genes regulated by RTA, and also the production of progeny virus was significantly reduced after treatment with chemical inducers. VVID00010991 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-7-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015217 - - Virus Protein RTA http://www.ncbi.nlm.nih.gov/gene/4961526 Downregulation RNA extraction and quantitative real-time PCR, Western blot analysis, Dual-luciferase reporter assay, PCR analysis of progeny virus. 21283761 Among these miRNAs, we report here that miR-K12-7 directly targets the replication and transcription activator (RTA) encoded by open reading frame 50. We found that miR-K12-7 targeted the RTA 3' untranslated region (RTA3'UTR) in a seed sequence-dependent manner. VVID00010992 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-7-5p(miR-K12-7-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015217 - - Virus Protein ORF50(ORF50/RTA) http://www.ncbi.nlm.nih.gov/gene/4961526 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VVID00010993 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K12-9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 - - Virus Protein ORF50(ORF50/RTA) http://www.ncbi.nlm.nih.gov/gene/4961526 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VVID00010994 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K12-9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 Lymphocytes - Virus Protein ORF50 http://www.ncbi.nlm.nih.gov/gene/4961526 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 K12-4-5p targeting retinoblastoma(Rb)-like protein 2(Rbl2) and miR-K12-5 and -9*suppressing ORF50 Mrna.Together, these data suggest mutiple roles for these viral microRNAs in pathogenesis and potentially tumorigenesis in the KSHV-infected host. . VVID00010995 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-miR-K12-9-5p(miR-K9*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002184 - - Virus Protein RTA # Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, assays of acute infection and CTL reactivity in vivo, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VVID00010996 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002475 - - Virus mRNA NFKBIA http://www.ncbi.nlm.nih.gov/gene/4792 - Experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs., crosslinking and immunoprecipitation (CLIP) assay. 23170179 Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets(Table 1).Table1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV - and EBV- encoded miRNA.ND- No data. VVID00010997 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 Lymphocytes - Virus Protein ORF50 http://www.ncbi.nlm.nih.gov/gene/4961526 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 K12-4-5p targeting retinoblastoma(Rb)-like protein 2(Rbl2) and miR-K12-5 and -9*suppressing ORF50 Mrna.Together, these data suggest mutiple roles for these viral microRNAs in pathogenesis and potentially tumorigenesis in the KSHV-infected host. . VVID00010998 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K12-5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 - - Virus Protein ORF50(ORF50/RTA) http://www.ncbi.nlm.nih.gov/gene/4961526 Downregulation Reporter Assay,Luciferase Reporter,Ectopic Reporter. 21616184 Currently, the validated targets of KSHV miRNAs (Table 1) represent a collection of genes identified by unbiased methods or chosen by previously identified functions. Table 1 KSHVmiRNA validated targets. All targets have been validated using ectopic expression of miRNAs to demonstrate that a luciferase reporter or ectopic reporter are repressed. Additional validations include(1) exogenous reporters have been mutated to disrupt targeting by a ectopic miRNA,(2) ectopic miRNA suppresses endogenous target mRNA and/or protein levels,(3) de novo infection with KSHV represses endogenous target expression,(4) miRNA inhibitors and/or mutant virus display derepression of endogenous target mRNA and/or protein levels, and(5) repression of miRNA target is observed in KSHV clinical samples. VVID00010999 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 - - Virus Protein ORF56 http://www.ncbi.nlm.nih.gov/gene/4961445 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VVID00011000 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 - - Virus Protein ORF56 http://www.ncbi.nlm.nih.gov/gene/4961445 Downregulation Bioinformatic miRNA Target Predictions and Seed Match Analyses, and Western Blotting, Dual Luciferase Reporter Assays, Whole-Cell Extracts, Plasmid Constructions, Immunoprecipitation. 21402938 miR-K5 and miR-K6-3p target ORF56 3'UTR.The phenotype of the mutation in Exon 1 not only indicates that this site is recognized by miR-K5, but also suggests it is the only functional recognition site for this miRNA in the ORF56 3'UTR.KSHV miR-K5 and miR-K6-3p down-regulate the expression of Renilla LUC reporter fused to genomic sequence of ORF56 3'UTR. HEK293 cells were cotransfected with each reporter construct (ORF56 3'UTR and VEC) along with a negative control miRNA (Ctl) or each of the indicated 20 KSHV miRNAs.Transfection conditions,. VVID00011001 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 - - Virus Protein ORF57 http://www.ncbi.nlm.nih.gov/gene/4961525 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VVID00011002 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 - - Virus Protein ORF57 http://www.ncbi.nlm.nih.gov/gene/4961525 Downregulation Bioinformatic miRNA Target Predictions and Seed Match Analyses, and Western Blotting, Dual Luciferase Reporter Assays, Whole-Cell Extracts, Plasmid Constructions, Immunoprecipitation. 21402938 Examination of the sequence of the ORF56/primase 3'UTR with several miRNA target prediction programs suggested two likely targets for miR-K5jone in Exon 1 of the ORF57 gene, and one in Exon 2 of the gene. The sequences of these target sites, and their predicted basepairing with miR-K5, are shown in Fig. 2B. VVID00011003 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-5(miR-K5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002481 - - Virus mRNA ORF50(RTA) http://www.ncbi.nlm.nih.gov/gene/4961526 - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VVID00011004 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-6(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 - - Virus Protein ORF57 http://www.ncbi.nlm.nih.gov/gene/4961525 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VVID00011005 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-6-3p http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002480 MRC5 and HEK293T cells - Virus mRNA Rta # - Predicted. 18378902 KSHV(gamma-herpesvirus) Rta(ORF 50) and Zta(ORF K8) are homologues of EBV BRLF1 and BZLF1, respectively, although functionally BZLF1 seems to correspond more to the Rta. The 3' UTR shared by Zta and Rta is likely targeted by the KSHV miR-K10-6-3p. VVID00011006 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 - - Virus Protein ORF56 http://www.ncbi.nlm.nih.gov/gene/4961445 - - 22100165 Our dataset also confirmed 12 out of 29 validated KSHV miRNA targets with expression in our dataset(>40%). Confirmed interactions include those with BACH1, FOS, CDKN1A(p21), TNFRSF12A(TWEAKR), RAD21 and RBL2 mRNAs, whose regulation had previously been validated at the level of protein expression. A list summarizing the recovery of previously published targets of the KSHV and EBV miRNAs is presented in Table S9. NIHMS333942-supplement-01 Table S9 Recovery of previously published targets for KSHV or EBV miRNAs. VVID00011007 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 - - Virus Protein ORF56 http://www.ncbi.nlm.nih.gov/gene/4961445 Downregulation Bioinformatic miRNA Target Predictions and Seed Match Analyses, and Western Blotting, Dual Luciferase Reporter Assays, Whole-Cell Extracts, Plasmid Constructions, Immunoprecipitation. 21402938 miR-K5 and miR-K6-3p target ORF56 3'UTR.The phenotype of the mutation in Exon 1 not only indicates that this site is recognized by miR-K5, but also suggests it is the only functional recognition site for this miRNA in the ORF56 3'UTR.KSHV miR-K5 and miR-K6-3p down-regulate the expression of Renilla LUC reporter fused to genomic sequence of ORF56 3'UTR. HEK293 cells were cotransfected with each reporter construct (ORF56 3'UTR and VEC) along with a negative control miRNA (Ctl) or each of the indicated 20 KSHV miRNAs.Transfection conditions,. VVID00011008 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-6-3p(miR-K6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002189 - - Virus Protein ORF57 http://www.ncbi.nlm.nih.gov/gene/4961525 Downregulation Bioinformatic miRNA Target Predictions and Seed Match Analyses, and Western Blotting, Dual Luciferase Reporter Assays, Whole-Cell Extracts, Plasmid Constructions, Immunoprecipitation. 21402938 We took a similar approach to map the target site(s) for miR-K6-3p in the ORF56 3'UTR. The locations of the top two target sites predicted computationally are shown in Fig. 2A. One site (termed Site 3) resides within the intron of the ORF57 gene, while the other (Site 4) maps to Exon 2 of ORF57. Fig. 2C shows that only the mutation in Site 3 abolishes miR-K6-3p action, indicating the target site for this miRNA is in the intron of ORF57. VVID00011009 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Virus miRNA kshv-mir-K12-9(miR-K9) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002477 - - Virus mRNA ORF50(RTA) http://www.ncbi.nlm.nih.gov/gene/4961526 - Genome wide analysis, CTL assays, Bioinformatic analysis. 20580307 From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs. VVID00011010 Marek's disease virus 1(MDV-1) Gallus gallus Virus miRNA mdv1-mir-M4(miR-M4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005096 - - Virus Protein UL28 http://www.ncbi.nlm.nih.gov/gene/2930809 Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, assays of acute infection and CTL reactivity in vivo, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VVID00011011 Marek's disease virus 1(MDV-1) Gallus gallus Virus miRNA mdv1-mir-M4(miR-M4) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005096 - - Virus Protein UL32 # Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, assays of acute infection and CTL reactivity in vivo, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VVID00011012 Polyoma virus(PyV) Homo sapiens Virus miRNA miR-P1 # - - Virus Protein LT-Ag # Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, assays of acute infection and CTL reactivity in vivo, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VVID00011013 Rhesus lymphocryptovirus(rLCV) Macaca mulatta Virus miRNA rlcv-miR-rL1-6-3p(miR-rL1-6-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003435 rLCV-infected rhesus macaquerLCLs - Virus Protein BHRF1 http://www.ncbi.nlm.nih.gov/gene/3783706 Downregulation Western blot analysis, PAR-CLIP, qRT-PCR for RISC-associated BHRF1 mRNAs,Luciferase reporter assays. 24257599 In addition to miR-BART10, we observed significant inhibition of the EBV BHRF1 3'UTR reporter in the presence of miR-BART1. miR-BART1-3p and its rLCV homolog, miR-rL1-6-3p, have seed matches (nt 2 to 8) to the EBV and rLCV BHRF1 3'UTRs, al-though the positions of the seed match sites and the miRNA inhibition are not conserved. . VVID00011014 Rhesus lymphocryptovirus(rLCV) Macaca mulatta Virus miRNA rlcv-miR-rL1-8-5p(miR-rL1-8-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003437 rLCV-infected rhesus macaquerLCLs - Virus mRNA LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - PAR-CLIP. 24257599 Intriguingly, seed matches for miR-rL1-8-5p, rL1-23, rL1-16, and rL1-28 were present in the herpesvirus papio LMP1 3'UTR sequence (not shown). VVID00011015 Rhesus lymphocryptovirus(rLCV) Macaca mulatta Virus miRNA rlcv-mir-rL1-16(miR-rL1-16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003752 rLCV-infected rhesus macaquerLCLs - Virus mRNA LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - PAR-CLIP. 24257599 Intriguingly, seed matches for miR-rL1-8-5p, rL1-23, rL1-16, and rL1-28 were present in the herpesvirus papio LMP1 3'UTR sequence (not shown). VVID00011016 Rhesus lymphocryptovirus(rLCV) Macaca mulatta Virus miRNA rlcv-mir-rL1-16(miR-rL1-16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003752 rLCV-infected rhesus macaquerLCLs - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - luciferase reporter assays, photoactivatable cross-linking and immunoprecipitation(PAR-CLIP), and deep sequencing and qRT-PCR. 24257599 Using luciferase reporter assays and by performing PAR-CLIP analysis of LCLs latently infected with EBV or rLCV, we show here that five EBV BART miRNAs (miR-BART3, miR-BART5, miR-BART16, miRBART17, and miR-BART20) and at least four rLCV BART miRNA homologs (miR-rL1-5, miR-rL1-8, miR-rL1-16, and miR-rL1-23) target LMP1 3'UTRs. VVID00011017 Rhesus lymphocryptovirus(rLCV) Macaca mulatta Virus miRNA rlcv-mir-rL1-23(miR-rL1-23) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013282 rLCV-infected rhesus macaquerLCLs - Virus mRNA LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - PAR-CLIP. 24257599 Intriguingly, seed matches for miR-rL1-8-5p, rL1-23, rL1-16, and rL1-28 were present in the herpesvirus papio LMP1 3'UTR sequence (not shown). VVID00011018 Rhesus lymphocryptovirus(rLCV) Macaca mulatta Virus miRNA rlcv-mir-rL1-23(miR-rL1-23) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013282 rLCV-infected rhesus macaquerLCLs - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - luciferase reporter assays, photoactivatable cross-linking and immunoprecipitation(PAR-CLIP), and deep sequencing and qRT-PCR. 24257599 Using luciferase reporter assays and by performing PAR-CLIP analysis of LCLs latently infected with EBV or rLCV, we show here that five EBV BART miRNAs (miR-BART3, miR-BART5, miR-BART16, miRBART17, and miR-BART20) and at least four rLCV BART miRNA homologs (miR-rL1-5, miR-rL1-8, miR-rL1-16, and miR-rL1-23) target LMP1 3'UTRs. VVID00011019 Rhesus lymphocryptovirus(rLCV) Macaca mulatta Virus miRNA rlcv-mir-rL1-28(miR-rL1-28) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013287 rLCV-infected rhesus macaquerLCLs - Virus mRNA LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - PAR-CLIP. 24257599 Intriguingly, seed matches for miR-rL1-8-5p, rL1-23, rL1-16, and rL1-28 were present in the herpesvirus papio LMP1 3'UTR sequence (not shown). VVID00011020 Rhesus lymphocryptovirus(rLCV) Macaca mulatta Virus miRNA rlcv-mir-rL1-5(miR-rL1-5) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003741 rLCV-infected rhesus macaquerLCLs - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - luciferase reporter assays, photoactivatable cross-linking and immunoprecipitation(PAR-CLIP), and deep sequencing and qRT-PCR. 24257599 Using luciferase reporter assays and by performing PAR-CLIP analysis of LCLs latently infected with EBV or rLCV, we show here that five EBV BART miRNAs (miR-BART3, miR-BART5, miR-BART16, miRBART17, and miR-BART20) and at least four rLCV BART miRNA homologs (miR-rL1-5, miR-rL1-8, miR-rL1-16, and miR-rL1-23) target LMP1 3'UTRs. VVID00011021 Rhesus lymphocryptovirus(rLCV) Macaca mulatta Virus miRNA rlcv-mir-rL1-8(miR-rL1-8) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003744 rLCV-infected rhesus macaquerLCLs - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - luciferase reporter assays, photoactivatable cross-linking and immunoprecipitation(PAR-CLIP), and deep sequencing and qRT-PCR. 24257599 Using luciferase reporter assays and by performing PAR-CLIP analysis of LCLs latently infected with EBV or rLCV, we show here that five EBV BART miRNAs (miR-BART3, miR-BART5, miR-BART16, miRBART17, and miR-BART20) and at least four rLCV BART miRNA homologs (miR-rL1-5, miR-rL1-8, miR-rL1-16, and miR-rL1-23) target LMP1 3'UTRs. VVID00011022 Simian virus 40(SV40) Callithrix jacchus Virus miRNA sv40-mir-S1(miR-S1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003689 - - Virus mRNA SV40gp6(T antigen) http://www.ncbi.nlm.nih.gov/gene/1489531 Downregulation - 19158788 These SV40 miRNAs, which show perfect complementarity to the T antigen mRNAs, induce their cleavage and degradation and reduce T antigen expression late in the SV40 life cycle. VVID00011023 Simian virus 40(SV40) Homo sapiens Virus miRNA sv40-miR-S1-5p(miR-S1-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003344 HeLa cells - Virus Protein SV40gp6(T antigen) http://www.ncbi.nlm.nih.gov/gene/1489531 Downregulation Fluorescence reporter assays. 22558366 Using the new reporter system, it was found that sv40-mir-S1-5p and hsa-miR423-5p downregulate the expression of common artificial target mRNAs and some predicted biological targets of hsa-miR423-5p, demonstrating that they are functional orthologs.These results demonstrated that SV40-encoded miRNA miR-S1-5p should act as a functional ortholog of the human-derived miRNA miR423-5p. SV40-encoded miR-S1-5p was reported to downregulate the expression of viral T antigen without reducing the yield of infectious virus,thus reducing host cytotoxic T lymphocyte (CTL) susceptibility and local cytokine release. . VVID00011024 Simian virus 40(SV40) Saimiri boliviensis Virus miRNA sv40-mir-S1(miR-S1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003689 - - Virus Protein LT-Ag # Downregulation QRT-PCR, standard assays of laboratory infection, combined with cDNA microarray analysis, computational analysis, high-throughput analysis methods, assays of acute infection and CTL reactivity in vivo, reporter assays, luciferase assays. 21277611 An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs. VVID00011025 White spot syndrome virus(WSSV) Shrimp Virus miRNA WSSV-miR-66 # - - Virus Protein Swssvgp094(wsv094) http://www.ncbi.nlm.nih.gov/gene/926782 - - 24198431 It was revealed that the WSSV wsv094 and wsv177 genes were the targets of WSSV-miR-66 and that the wsv248 and wsv309 genes were the targets of WSSV-miR-68. The data demonstrate that the four target genes play negative roles in the WSSV infection. The targeting of the four virus genes by WSSV-miR-66 and WSSV-miR-68 led to the promotion of virus infection. . VVID00011026 White spot syndrome virus(WSSV) Shrimp Virus miRNA WSSV-miR-66 # - - Virus Protein Swssvgp177(wsv177) http://www.ncbi.nlm.nih.gov/gene/926942 - - 24198431 It was revealed that the WSSV wsv094 and wsv177 genes were the targets of WSSV-miR-66 and that the wsv248 and wsv309 genes were the targets of WSSV-miR-68. The data demonstrate that the four target genes play negative roles in the WSSV infection. The targeting of the four virus genes by WSSV-miR-66 and WSSV-miR-68 led to the promotion of virus infection. . VVID00011027 White spot syndrome virus(WSSV) Shrimp Virus miRNA WSSV-miR-68 # - - Virus Protein Swssvgp248(wsv248) http://www.ncbi.nlm.nih.gov/gene/926945 - - 24198431 It was revealed that the WSSV wsv094 and wsv177 genes were the targets of WSSV-miR-66 and that the wsv248 and wsv309 genes were the targets of WSSV-miR-68. The data demonstrate that the four target genes play negative roles in the WSSV infection. The targeting of the four virus genes by WSSV-miR-66 and WSSV-miR-68 led to the promotion of virus infection. . VVID00011028 White spot syndrome virus(WSSV) Shrimp Virus miRNA WSSV-miR-68 # - - Virus Protein Swssvgp309(wsv309) http://www.ncbi.nlm.nih.gov/gene/927121 - - 24198431 It was revealed that the WSSV wsv094 and wsv177 genes were the targets of WSSV-miR-66 and that the wsv248 and wsv309 genes were the targets of WSSV-miR-68. The data demonstrate that the four target genes play negative roles in the WSSV infection. The targeting of the four virus genes by WSSV-miR-66 and WSSV-miR-68 led to the promotion of virus infection. . HHID00011029 Andes hantavirus(ANDV) Homo sapiens Host miRNA hsa-mir-126 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000471 Endothelial cells Upregulation Host Protein PIK3R2 http://www.ncbi.nlm.nih.gov/gene/5296 Downregulation Immunoperoxidase staining of hantavirus-infected cells, cDNA synthesis, EC permeability assay, siRNA transfection, Western blot analysis, RT-PCR arrays, miRNA array real-time PCR, qRT-PCR of cellular mRNAs, MicroRNA and total RNA purification. 20844033 We further analyzed changes in miR-126, an EC-specific miRNA that regulates vascular integrity by suppressing SPRED1 and PIK3R2 mRNAs.The level of miR-126, which has a known function in regulating vascular permeability, increased approximately 2-fold following ANDV infection. HHID00011030 Andes hantavirus(ANDV) Homo sapiens Host miRNA hsa-mir-126 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000471 Endothelial cells Upregulation Host Protein SPRED1 http://www.ncbi.nlm.nih.gov/gene/161742 Downregulation Immunoperoxidase staining of hantavirus-infected cells, cDNA synthesis, EC permeability assay, siRNA transfection, Western blot analysis, RT-PCR arrays, miRNA array real-time PCR, qRT-PCR of cellular mRNAs, MicroRNA and total RNA purification. 20844033 We further analyzed changes in miR-126, an EC-specific miRNA that regulates vascular integrity by suppressing SPRED1 and PIK3R2 mRNAs.The level of miR-126, which has a known function in regulating vascular permeability, increased approximately 2-fold following ANDV infection. HHID00011031 Avian leukosis virus(ALV) Gallus gallus Host miRNA gga-mir-26a(gga-miR-26a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001187 Chicken lymphoma cells Downregulation Host Protein IL-2 http://www.ncbi.nlm.nih.gov/gene/373958 - Analysis of miRNA expression, Analysis of IL-2 expression, reporter and biochemical assays. 20441582 The expression levels of gga-miR-26a in chicken lymphoma cells transformed by 3 distinct avian oncogenic viruses, viz Marek's disease virus (MDV), avian leukosis virus (ALV) and Reticuloendotheliosis virus (REV) were consistently downregulated compared to the levels in the normal lymphocytes. We demonstrate the additional role of this miRNA in directly targeting chicken IL-2 through reporter and biochemical assays. The downregulation of miR-26a can relieve the suppressive effect of this miRNA on IL-2 expression. HHID00011032 Coxsackievirus B3(CVB3) Mus musculus Host miRNA mmu-mir-203(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000246 CVB3-infected Mus musculus hearts Upregulation Host Protein Prkca http://www.ncbi.nlm.nih.gov/gene/18750 Upregulation microarray analysis. 22842794 To identify miRNAs involved in CVB3 pathogenesis, we performed microarray analysis of miRNAs using CVB3-infected murine hearts and identified miR-203 as one of the most upregulated candidates. We found that miR-203 upregulation is through the activation of protein kinase C/transcription factor AP-1 pathway. HHID00011033 Coxsackievirus B3(CVB3) Mus musculus Host miRNA mmu-mir-203(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000246 CVB3-infected Mus musculus hearts Upregulation Host Protein Prkcb http://www.ncbi.nlm.nih.gov/gene/18751 Upregulation microarray analysis. 22842794 To identify miRNAs involved in CVB3 pathogenesis, we performed microarray analysis of miRNAs using CVB3-infected murine hearts and identified miR-203 as one of the most upregulated candidates. We found that miR-203 upregulation is through the activation of protein kinase C/transcription factor AP-1 pathway. HHID00011034 Coxsackievirus B3(CVB3) Mus musculus Host miRNA mmu-mir-203(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000246 CVB3-infected Mus musculus hearts Upregulation Host Protein Prkcd http://www.ncbi.nlm.nih.gov/gene/18753 Upregulation microarray analysis. 22842794 To identify miRNAs involved in CVB3 pathogenesis, we performed microarray analysis of miRNAs using CVB3-infected murine hearts and identified miR-203 as one of the most upregulated candidates. We found that miR-203 upregulation is through the activation of protein kinase C/transcription factor AP-1 pathway. HHID00011035 Coxsackievirus B3(CVB3) Mus musculus Host miRNA mmu-mir-203(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000246 CVB3-infected Mus musculus hearts Upregulation Host Protein Prkce http://www.ncbi.nlm.nih.gov/gene/18754 Upregulation microarray analysis. 22842794 To identify miRNAs involved in CVB3 pathogenesis, we performed microarray analysis of miRNAs using CVB3-infected murine hearts and identified miR-203 as one of the most upregulated candidates. We found that miR-203 upregulation is through the activation of protein kinase C/transcription factor AP-1 pathway. HHID00011036 Coxsackievirus B3(CVB3) Mus musculus Host miRNA mmu-mir-203(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000246 CVB3-infected Mus musculus hearts Upregulation Host Protein Prkcg http://www.ncbi.nlm.nih.gov/gene/18752 Upregulation microarray analysis. 22842794 To identify miRNAs involved in CVB3 pathogenesis, we performed microarray analysis of miRNAs using CVB3-infected murine hearts and identified miR-203 as one of the most upregulated candidates. We found that miR-203 upregulation is through the activation of protein kinase C/transcription factor AP-1 pathway. HHID00011037 Coxsackievirus B3(CVB3) Mus musculus Host miRNA mmu-mir-203(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000246 CVB3-infected Mus musculus hearts Upregulation Host Protein Prkch http://www.ncbi.nlm.nih.gov/gene/18755 Upregulation microarray analysis. 22842794 To identify miRNAs involved in CVB3 pathogenesis, we performed microarray analysis of miRNAs using CVB3-infected murine hearts and identified miR-203 as one of the most upregulated candidates. We found that miR-203 upregulation is through the activation of protein kinase C/transcription factor AP-1 pathway. HHID00011038 Coxsackievirus B3(CVB3) Mus musculus Host miRNA mmu-mir-203(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000246 CVB3-infected Mus musculus hearts Upregulation Host Protein Prkci http://www.ncbi.nlm.nih.gov/gene/18759 Upregulation microarray analysis. 22842794 To identify miRNAs involved in CVB3 pathogenesis, we performed microarray analysis of miRNAs using CVB3-infected murine hearts and identified miR-203 as one of the most upregulated candidates. We found that miR-203 upregulation is through the activation of protein kinase C/transcription factor AP-1 pathway. HHID00011039 Coxsackievirus B3(CVB3) Mus musculus Host miRNA mmu-mir-203(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000246 CVB3-infected Mus musculus hearts Upregulation Host Protein Prkcq http://www.ncbi.nlm.nih.gov/gene/18761 Upregulation microarray analysis. 22842794 To identify miRNAs involved in CVB3 pathogenesis, we performed microarray analysis of miRNAs using CVB3-infected murine hearts and identified miR-203 as one of the most upregulated candidates. We found that miR-203 upregulation is through the activation of protein kinase C/transcription factor AP-1 pathway. HHID00011040 Coxsackievirus B3(CVB3) Mus musculus Host miRNA mmu-mir-203(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000246 CVB3-infected Mus musculus hearts Upregulation Host Protein Prkcz http://www.ncbi.nlm.nih.gov/gene/18762 Upregulation microarray analysis. 22842794 To identify miRNAs involved in CVB3 pathogenesis, we performed microarray analysis of miRNAs using CVB3-infected murine hearts and identified miR-203 as one of the most upregulated candidates. We found that miR-203 upregulation is through the activation of protein kinase C/transcription factor AP-1 pathway. HHID00011041 Coxsackievirus B3(CVB3) Mus musculus Host miRNA mmu-mir-203(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000246 Hearts Upregulation Host Protein Zfp148 http://www.ncbi.nlm.nih.gov/gene/22661 Downregulation Western blot analysis, Construction of luciferase reporter plasmids and its mutants, Quantitative real-time RT-PCR, Cell culture transfection, H&E staining and echocardiography, Luciferase reporter analysis, Viral plaque assay, Live-cell confocal imaging, Statistical analysis, Cell viability assay, MicroRNA microarray. 22842794 MicroRNA-203 enhances coxsackievirus B3 replication through targeting zinc finger protein-148. We further identified zinc finger protein-148(ZFP-148), a transcription factor, as a novel target of miR-203. HHID00011042 Coxsackievirus B3(CVB3) Mus musculus Host miRNA mmu-mir-21a(miR-21) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000569 Cardiovascular Downregulation Host Protein PDCD4 http://www.ncbi.nlm.nih.gov/gene/18569 Downregulation Real-time PCR. 23544605 Further study showed that miR-21 could protect myocardial apoptosis by specifically inhibiting its target programmed cell death 4(PDCD4) expression.Myocardial microRNA expression changes in CVB3-infected mice were analyzed by real-time PCR and miR-21 was found to be the miRNA whose expression was significantly reduced. miR-21 administration efficiently alleviated CVB3-induced myocarditis by repressing PDCD4-mediated apoptosis. HHID00011043 Cucumber mosaic virus(CMV) Solanum lycopersicum Host miRNA sly-MIR164a(miR164) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0027570 - - Host Protein NAC1 http://www.ncbi.nlm.nih.gov/gene/543917 - RT-PCR. 21590278 NAC1, HD-ZIP and TCP4, were up-regulated during the pathogenic processes after CMV-Fny, CMV-Fny-satT1 and TAV-Bj infections. NAC1 is regulated by miR164, it has been reported that NAC1 controls lamina outgrowth on a grander scale than that of serrations [24]. Reduction of NAC gene function in a wide range of compound leaved plants reduces the number of leaflet and results in leaflet fusions as well as suppressing serrations [25, 26]. MiR165/166-regulated HD-ZIP is important for establishing the adaxial cell fate during leaf dorso-ventral patterning. MiR319-regulated TCP4 is also indispensable for proper leaf morphogenesis and leaf senescence [24, 27]. HHID00011044 Cucumber mosaic virus(CMV) Solanum lycopersicum Host miRNA sly-MIR164b(miR164) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0027571 - - Host Protein NAC1 http://www.ncbi.nlm.nih.gov/gene/543917 - RT-PCR. 21590278 NAC1, HD-ZIP and TCP4, were up-regulated during the pathogenic processes after CMV-Fny, CMV-Fny-satT1 and TAV-Bj infections. NAC1 is regulated by miR164, it has been reported that NAC1 controls lamina outgrowth on a grander scale than that of serrations [24]. Reduction of NAC gene function in a wide range of compound leaved plants reduces the number of leaflet and results in leaflet fusions as well as suppressing serrations [25, 26]. MiR165/166-regulated HD-ZIP is important for establishing the adaxial cell fate during leaf dorso-ventral patterning. MiR319-regulated TCP4 is also indispensable for proper leaf morphogenesis and leaf senescence [24, 27]. HHID00011045 Cucumber mosaic virus(CMV) Solanum lycopersicum Host miRNA sly-MIR166a(miR166) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008358 - - Host Protein HD-ZIP http://www.ncbi.nlm.nih.gov/gene/544105 - RT-PCR. 21590278 NAC1, HD-ZIP and TCP4, were up-regulated during the pathogenic processes after CMV-Fny, CMV-Fny-satT1 and TAV-Bj infections. NAC1 is regulated by miR164, it has been reported that NAC1 controls lamina outgrowth on a grander scale than that of serrations [24]. Reduction of NAC gene function in a wide range of compound leaved plants reduces the number of leaflet and results in leaflet fusions as well as suppressing serrations [25, 26]. MiR165/166-regulated HD-ZIP is important for establishing the adaxial cell fate during leaf dorso-ventral patterning. MiR319-regulated TCP4 is also indispensable for proper leaf morphogenesis and leaf senescence [24, 27]. HHID00011046 Cucumber mosaic virus(CMV) Solanum lycopersicum Host miRNA sly-MIR166b(miR166) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0009972 - - Host Protein HD-ZIP http://www.ncbi.nlm.nih.gov/gene/544105 - RT-PCR. 21590278 NAC1, HD-ZIP and TCP4, were up-regulated during the pathogenic processes after CMV-Fny, CMV-Fny-satT1 and TAV-Bj infections. NAC1 is regulated by miR164, it has been reported that NAC1 controls lamina outgrowth on a grander scale than that of serrations [24]. Reduction of NAC gene function in a wide range of compound leaved plants reduces the number of leaflet and results in leaflet fusions as well as suppressing serrations [25, 26]. MiR165/166-regulated HD-ZIP is important for establishing the adaxial cell fate during leaf dorso-ventral patterning. MiR319-regulated TCP4 is also indispensable for proper leaf morphogenesis and leaf senescence [24, 27]. HHID00011047 Cucumber mosaic virus(CMV) Solanum lycopersicum Host miRNA sly-MIR166c(miR166) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0029105 - - Host Protein HD-ZIP http://www.ncbi.nlm.nih.gov/gene/544105 - RT-PCR. 21590278 NAC1, HD-ZIP and TCP4, were up-regulated during the pathogenic processes after CMV-Fny, CMV-Fny-satT1 and TAV-Bj infections. NAC1 is regulated by miR164, it has been reported that NAC1 controls lamina outgrowth on a grander scale than that of serrations [24]. Reduction of NAC gene function in a wide range of compound leaved plants reduces the number of leaflet and results in leaflet fusions as well as suppressing serrations [25, 26]. MiR165/166-regulated HD-ZIP is important for establishing the adaxial cell fate during leaf dorso-ventral patterning. MiR319-regulated TCP4 is also indispensable for proper leaf morphogenesis and leaf senescence [24, 27]. HHID00011048 Cucumber mosaic virus(CMV) Solanum lycopersicum Host miRNA sly-MIR319a(miR319) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0009978 - - Host Protein TCP4 http://www.ncbi.nlm.nih.gov/gene/100736453 - RT-PCR. 21590278 NAC1, HD-ZIP and TCP4, were up-regulated during the pathogenic processes after CMV-Fny, CMV-Fny-satT1 and TAV-Bj infections. NAC1 is regulated by miR164, it has been reported that NAC1 controls lamina outgrowth on a grander scale than that of serrations [24]. Reduction of NAC gene function in a wide range of compound leaved plants reduces the number of leaflet and results in leaflet fusions as well as suppressing serrations [25, 26]. MiR165/166-regulated HD-ZIP is important for establishing the adaxial cell fate during leaf dorso-ventral patterning. MiR319-regulated TCP4 is also indispensable for proper leaf morphogenesis and leaf senescence [24, 27]. HHID00011049 Cucumber mosaic virus(CMV) Solanum lycopersicum Host miRNA sly-MIR319b(miR319) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0029098 - - Host Protein TCP4 http://www.ncbi.nlm.nih.gov/gene/100736453 - RT-PCR. 21590278 NAC1, HD-ZIP and TCP4, were up-regulated during the pathogenic processes after CMV-Fny, CMV-Fny-satT1 and TAV-Bj infections. NAC1 is regulated by miR164, it has been reported that NAC1 controls lamina outgrowth on a grander scale than that of serrations [24]. Reduction of NAC gene function in a wide range of compound leaved plants reduces the number of leaflet and results in leaflet fusions as well as suppressing serrations [25, 26]. MiR165/166-regulated HD-ZIP is important for establishing the adaxial cell fate during leaf dorso-ventral patterning. MiR319-regulated TCP4 is also indispensable for proper leaf morphogenesis and leaf senescence [24, 27]. HHID00011050 Cucumber mosaic virus(CMV) Solanum lycopersicum Host miRNA sly-MIR319c(miR319) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0029099 - - Host Protein TCP4 http://www.ncbi.nlm.nih.gov/gene/100736453 - RT-PCR. 21590278 NAC1, HD-ZIP and TCP4, were up-regulated during the pathogenic processes after CMV-Fny, CMV-Fny-satT1 and TAV-Bj infections. NAC1 is regulated by miR164, it has been reported that NAC1 controls lamina outgrowth on a grander scale than that of serrations [24]. Reduction of NAC gene function in a wide range of compound leaved plants reduces the number of leaflet and results in leaflet fusions as well as suppressing serrations [25, 26]. MiR165/166-regulated HD-ZIP is important for establishing the adaxial cell fate during leaf dorso-ventral patterning. MiR319-regulated TCP4 is also indispensable for proper leaf morphogenesis and leaf senescence [24, 27]. HHID00011051 Cytomegalovirus(CMV) Solanum lycopersicum Host miRNA sly-MIR156a(miR156) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0009971 - - Host Protein SPL # Upregulation Microarray analysis, RT-PCR. 23277401 In open flower, AP2, NAC1, and SPL levels in CMV-Fny-satT1 infected plants were most apparently increased. The transcript levels of SPL, MYB, ARF10, DCL1, NAC1, ARF8, AGO1, SCL and AP2, as targets of miR156, miR159, miR160, miR162, miR164, miR167, miR168, miR171 and miR172 were also quantified using the same RNA preparations. HHID00011052 Cytomegalovirus(CMV) Solanum lycopersicum Host miRNA sly-MIR156b(miR156) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0009971 - - Host Protein SPL # Upregulation Microarray analysis, RT-PCR. 23277401 In open flower, AP2, NAC1, and SPL levels in CMV-Fny-satT1 infected plants were most apparently increased. The transcript levels of SPL, MYB, ARF10, DCL1, NAC1, ARF8, AGO1, SCL and AP2, as targets of miR156, miR159, miR160, miR162, miR164, miR167, miR168, miR171 and miR172 were also quantified using the same RNA preparations. HHID00011053 Cytomegalovirus(CMV) Solanum lycopersicum Host miRNA sly-MIR156c(miR156) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0009973 - - Host Protein SPL # Upregulation Microarray analysis, RT-PCR. 23277401 In open flower, AP2, NAC1, and SPL levels in CMV-Fny-satT1 infected plants were most apparently increased. The transcript levels of SPL, MYB, ARF10, DCL1, NAC1, ARF8, AGO1, SCL and AP2, as targets of miR156, miR159, miR160, miR162, miR164, miR167, miR168, miR171 and miR172 were also quantified using the same RNA preparations. HHID00011054 Cytomegalovirus(CMV) Solanum lycopersicum Host miRNA sly-MIR156d(miR156) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0029109 - - Host Protein SPL # Upregulation Microarray analysis, RT-PCR. 23277401 In open flower, AP2, NAC1, and SPL levels in CMV-Fny-satT1 infected plants were most apparently increased. The transcript levels of SPL, MYB, ARF10, DCL1, NAC1, ARF8, AGO1, SCL and AP2, as targets of miR156, miR159, miR160, miR162, miR164, miR167, miR168, miR171 and miR172 were also quantified using the same RNA preparations. HHID00011055 Cytomegalovirus(CMV) Solanum lycopersicum Host miRNA sly-MIR156e(miR156) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0029110 - - Host Protein SPL # Upregulation Microarray analysis, RT-PCR. 23277401 In open flower, AP2, NAC1, and SPL levels in CMV-Fny-satT1 infected plants were most apparently increased. The transcript levels of SPL, MYB, ARF10, DCL1, NAC1, ARF8, AGO1, SCL and AP2, as targets of miR156, miR159, miR160, miR162, miR164, miR167, miR168, miR171 and miR172 were also quantified using the same RNA preparations. HHID00011056 Cytomegalovirus(CMV) Solanum lycopersicum Host miRNA sly-MIR159(miR159) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0009974 - - Host Protein MYB http://www.ncbi.nlm.nih.gov/gene/100125893 Upregulation Microarray analysis, RT-PCR. 23277401 AGO1 level in CMV-Fny and CMV-Fny-satT1 infections, ARF10, MYB and NAC1 levels in CMV-Fny2b infection, and AP2, MYB and NAC1 levels in TAV-Bj infection were approximately double those of mock-inoculated plants.The transcript levels of SPL, MYB, ARF10, DCL1, NAC1, ARF8, AGO1, SCL and AP2, as targets of miR156, miR159, miR160, miR162, miR164, miR167, miR168, miR171 and miR172 were also quantified using the same RNA preparations. HHID00011057 Cytomegalovirus(CMV) Solanum lycopersicum Host miRNA sly-MIR164a(miR164) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0027570 - - Host Protein NAC1 http://www.ncbi.nlm.nih.gov/gene/543917 Upregulation Microarray analysis, RT-PCR. 23277401 In the closed flower bud, the expression levels of NAC1 were most significantly increased in CMV-Fny, CMV-Fny-satT1 and TAV-Bj infections (RQ >15).The transcript levels of SPL, MYB, ARF10, DCL1, NAC1, ARF8, AGO1, SCL and AP2, as targets of miR156, miR159, miR160, miR162, miR164, miR167, miR168, miR171 and miR172 were also quantified using the same RNA preparations. HHID00011058 Cytomegalovirus(CMV) Solanum lycopersicum Host miRNA sly-MIR164b(miR164) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0027571 - - Host Protein NAC1 http://www.ncbi.nlm.nih.gov/gene/543917 Upregulation Microarray analysis, RT-PCR. 23277401 In the closed flower bud, the expression levels of NAC1 were most significantly increased in CMV-Fny, CMV-Fny-satT1 and TAV-Bj infections (RQ >15).The transcript levels of SPL, MYB, ARF10, DCL1, NAC1, ARF8, AGO1, SCL and AP2, as targets of miR156, miR159, miR160, miR162, miR164, miR167, miR168, miR171 and miR172 were also quantified using the same RNA preparations. HHID00011059 Cytomegalovirus(CMV) Solanum lycopersicum Host miRNA sly-MIR168a(miR168) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0024352 - - Host Protein AGO1B(AGO1) http://www.ncbi.nlm.nih.gov/gene/101255074 Upregulation Microarray analysis, RT-PCR. 23277401 AGO1 level in CMV-Fny and CMV-Fny-satT1 infections, ARF10, MYB and NAC1 levels in CMV-Fny2b infection, and AP2, MYB and NAC1 levels in TAV-Bj infection were approximately double those of mock-inoculated plants.The transcript levels of SPL, MYB, ARF10, DCL1, NAC1, ARF8, AGO1, SCL and AP2, as targets of miR156, miR159, miR160, miR162, miR164, miR167, miR168, miR171 and miR172 were also quantified using the same RNA preparations. HHID00011060 Cytomegalovirus(CMV) Solanum lycopersicum Host miRNA sly-MIR168b(miR168) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0024353 - - Host Protein AGO1B(AGO1) http://www.ncbi.nlm.nih.gov/gene/101255074 Upregulation Microarray analysis, RT-PCR. 23277401 AGO1 level in CMV-Fny and CMV-Fny-satT1 infections, ARF10, MYB and NAC1 levels in CMV-Fny2b infection, and AP2, MYB and NAC1 levels in TAV-Bj infection were approximately double those of mock-inoculated plants.The transcript levels of SPL, MYB, ARF10, DCL1, NAC1, ARF8, AGO1, SCL and AP2, as targets of miR156, miR159, miR160, miR162, miR164, miR167, miR168, miR171 and miR172 were also quantified using the same RNA preparations. HHID00011061 Cytomegalovirus(CMV) Solanum lycopersicum Host miRNA sly-MIR172a(miR172) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0009976 - - Host Protein RAV1(AP2) http://www.ncbi.nlm.nih.gov/gene/101259430 Upregulation Microarray analysis, RT-PCR. 23277401 AGO1 level in CMV-Fny and CMV-Fny-satT1 infections, ARF10, MYB and NAC1 levels in CMV-Fny2b infection, and AP2, MYB and NAC1 levels in TAV-Bj infection were approximately double those of mock-inoculated plants.The transcript levels of SPL, MYB, ARF10, DCL1, NAC1, ARF8, AGO1, SCL and AP2, as targets of miR156, miR159, miR160, miR162, miR164, miR167, miR168, miR171 and miR172 were also quantified using the same RNA preparations. HHID00011062 Cytomegalovirus(CMV) Solanum lycopersicum Host miRNA sly-MIR172b(miR172) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0009977 - - Host Protein RAV1(AP2) http://www.ncbi.nlm.nih.gov/gene/101259430 Upregulation Microarray analysis, RT-PCR. 23277401 AGO1 level in CMV-Fny and CMV-Fny-satT1 infections, ARF10, MYB and NAC1 levels in CMV-Fny2b infection, and AP2, MYB and NAC1 levels in TAV-Bj infection were approximately double those of mock-inoculated plants.The transcript levels of SPL, MYB, ARF10, DCL1, NAC1, ARF8, AGO1, SCL and AP2, as targets of miR156, miR159, miR160, miR162, miR164, miR167, miR168, miR171 and miR172 were also quantified using the same RNA preparations. HHID00011063 Enterovirus 71(EV71) Homo sapiens Host miRNA hsa-mir-548(miRNA-548) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003593 HepG2 cells Downregulation Host Protein IFN-lambda1 http://www.ncbi.nlm.nih.gov/gene/282618 Downregulation Cell culture, transfection, and detection of IFN-λ1 protein,Construction of 3′UTR reporter plasmid and luciferase reporter assay,Reverse transcription reaction and quantitative real-time PCR,Viruses and measurement of viral replication and expression,mRNA decay assay,In vitro cytotoxicity assays. 23150165 miRNA-548 mimics promoted infection by enteroVirus-71 (EV71) and vesicular stomatitis Virus (VSV), whereas their inhibitors significantly suppressed the replication of EV71 and VSV. Endogenous miRNA-548 levels were suppressed during viral infection. In conclusion, our results suggest that miRNA-548 regulates host antiviral response via direct targeting of IFN-lambda1, which may offer a potential candidate for antiviral therapy. HHID00011064 Epstein-Barr virus(EBV) Homo sapiens Host miRNA has-mir-127(hsa-miR-127) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000472 Burkitt lymphoma Upregulation Host mRNA BCL6 http://www.ncbi.nlm.nih.gov/gene/604 Upregulation Immunization and cell sorting, Luciferase assay, Quantitative reverse transcription-PCR, Retroviral infection, Indirect immunofluorescence, Western blotting(WB), B-cell isolation, Nucleofection. 22941339 The combinatorial expression of hsa-miR-127 and EBNA1 provides evidence of a modulation of B-cell markers in human memory B cells, resulting in a decrease of BLIMP-1, XBP-1 and IRF-4, and an increase in BCL-6 and CD10 mRNA, thus confirming the scenario previously observed in EBV-positive BL primary tumors and cell lines. HHID00011065 Epstein-Barr virus(EBV) Homo sapiens Host miRNA has-mir-127(hsa-miR-127) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000472 Burkitt lymphoma Upregulation Host mRNA IRF4 http://www.ncbi.nlm.nih.gov/gene/3662 Downregulation Immunization and cell sorting, Luciferase assay, Quantitative reverse transcription-PCR, Retroviral infection, Indirect immunofluorescence, Western blotting(WB), B-cell isolation, Nucleofection. 22941339 Our previous findings suggested that upregulation of hsa-miR-127 in EBV-positive BL may determine the downregulation of BLIMP-1 and XBP-1 and the consequent persistence of BCL-6 expression, as well as the GC phenotype in B cells that have already differentiated towards memory B cells in terms of Ig mutation pattern. HHID00011066 Epstein-Barr virus(EBV) Homo sapiens Host miRNA has-mir-127(hsa-miR-127) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000472 Burkitt lymphoma Upregulation Host mRNA MME(CD10) http://www.ncbi.nlm.nih.gov/gene/4311 Upregulation Immunization and cell sorting, Luciferase assay, Quantitative reverse transcription-PCR, Retroviral infection, Indirect immunofluorescence, Western blotting(WB), B-cell isolation, Nucleofection. 22941339 The combinatorial expression of hsa-miR-127 and EBNA1 provides evidence of a modulation of B-cell markers in human memory B cells, resulting in a decrease of BLIMP-1, XBP-1 and IRF-4, and an increase in BCL-6 and CD10 mRNA, thus confirming the scenario previously observed in EBV-positive BL primary tumors and cell lines. HHID00011067 Epstein-Barr virus(EBV) Homo sapiens Host miRNA has-mir-127(hsa-miR-127) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000472 Burkitt lymphoma Upregulation Host mRNA PRDM1(BLIMP-1) http://www.ncbi.nlm.nih.gov/gene/639 Downregulation Immunization and cell sorting, Luciferase assay, Quantitative reverse transcription-PCR, Retroviral infection, Indirect immunofluorescence, Western blotting(WB), B-cell isolation, Nucleofection. 22941339 Our previous findings suggested that upregulation of hsa-miR-127 in EBV-positive BL may determine the downregulation of BLIMP-1 and XBP-1 and the consequent persistence of BCL-6 expression, as well as the GC phenotype in B cells that have already differentiated towards memory B cells in terms of Ig mutation pattern . HHID00011068 Epstein-Barr virus(EBV) Homo sapiens Host miRNA has-mir-127(hsa-miR-127) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000472 Burkitt lymphoma Upregulation Host mRNA XBP1 http://www.ncbi.nlm.nih.gov/gene/7494 Downregulation Immunization and cell sorting, Luciferase assay, Quantitative reverse transcription-PCR, Retroviral infection, Indirect immunofluorescence, Western blotting(WB), B-cell isolation, Nucleofection. 22941339 Our previous findings suggested that upregulation of hsa-miR-127 in EBV-positive BL may determine the downregulation of BLIMP-1 and XBP-1 and the consequent persistence of BCL-6 expression, as well as the GC phenotype in B cells that have already differentiated towards memory B cells in terms of Ig mutation pattern. HHID00011069 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-miR-142-3p(miR-142-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000434 NK/T-cell lymphomas Downregulation Host Protein IL1A http://www.ncbi.nlm.nih.gov/gene/3552 Downregulation Small RNA Cloning, qRT-PCR, Western Blotting, Northern Blot, ELISA, Sequence Annotation, Luciferase Assays. 22870299 We show that the proinflammatory cytokine interleukin 1 alpha(IL1A) is a target for miR-142-3p and the oncogenic BCL6 for miR-205.MiR-205 was undetectable in EBV-negative lymphoma and strongly down-regulated in EBV-positive NK/T-cell lymphoma as compared to thymus. HHID00011070 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-miR-296-3p(miR-296-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004679 Lymphoblastoid cell lines - Host Protein HbA1C http://www.ncbi.nlm.nih.gov/gene/3039 - miRNA microarray approach with early- (p6) and late-passage (p161) LCLs, Linear regression analysis. 21199010 MicroRNA signatures associated with immortalization of EBV-transformed lymphoblastoid cell lines and their clinical traits. In particular, miR-125b was up-regulated in all the tested late-passage LCLs. miR-99a, miR-125b, miR-216a and miR-1296 were putative negative regulators of RASGRP3, GPR160, PRKCH and XAF1, respectively, which were found to be differentially expressed in LCLs during long-term culture in a previous study. Linear regression analysis showed that miR-200a and miR-296-3p correlated with triglyceride and HbA1C levels. HHID00011071 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-miR-338-3p(miR-338-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000763 LO2 cells Downregulation Host Protein CCND1(Cyclin D1) http://www.ncbi.nlm.nih.gov/gene/595 Downregulation Immunohistochemistry, Statistical Analysis, Luciferase Reporter Assay, RT-PCR and Western Blot Analysis, EdU Assay, Cell Cycle Assay, Cell Transfection. 22942717 This study demonstrates that miR-338-3p inhibits proliferation by regulating CyclinD1, and HBx down-regulates miR-338-3p in HCC. HHID00011072 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-125b(miR-125b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000446 Lymphoblastoid cell lines - Host Protein GPR160 http://www.ncbi.nlm.nih.gov/gene/26996 Downregulation miRNA microarray approach with early- (p6) and late-passage (p161) LCLs, Linear regression analysis. 21199010 MicroRNA signatures associated with immortalization of EBV-transformed lymphoblastoid cell lines and their clinical traits. In particular, miR-125b was up-regulated in all the tested late-passage LCLs. miR-99a, miR-125b, miR-216a and miR-1296 were putative negative regulators of RASGRP3, GPR160, PRKCH and XAF1, respectively, which were found to be differentially expressed in LCLs during long-term culture in a previous study. Linear regression analysis showed that miR-200a and miR-296-3p correlated with triglyceride and HbA1C levels. HHID00011073 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-127(hsa-miR-127) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000472 B-cells Upregulation Host Protein BLIMP1 http://www.ncbi.nlm.nih.gov/gene/639 - Real-time PCR, Laser capture microdissection, Reporter construction and luciferase assay, Western blotting. 19530237 We found evidence that hsa-miR-127 is involved in B-cell differentiation process through posttranscriptional regulation of BLIMP1 and XBP1. The overexpression of this miRNA may thus represent a key event in the lymphomagenesis of EBV positive BL, by blocking the B-cell differentiation process. HHID00011074 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-127(hsa-miR-127) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000472 B-cells Upregulation Host Protein XBP1 http://www.ncbi.nlm.nih.gov/gene/7495 - Real-time PCR, Laser capture microdissection, Reporter construction and luciferase assay, Western blotting. 19530237 We found evidence that hsa-miR-127 is involved in B-cell differentiation process through posttranscriptional regulation of BLIMP1 and XBP1. The overexpression of this miRNA may thus represent a key event in the lymphomagenesis of EBV positive BL, by blocking the B-cell differentiation process. HHID00011075 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-1296(miR-1296) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003780 Lymphoblastoid cell lines - Host Protein XAF1 http://www.ncbi.nlm.nih.gov/gene/54739 Downregulation miRNA microarray approach with early- (p6) and late-passage (p161) LCLs, Linear regression analysis. 21199010 MicroRNA signatures associated with immortalization of EBV-transformed lymphoblastoid cell lines and their clinical traits. In particular, miR-125b was up-regulated in all the tested late-passage LCLs. miR-99a, miR-125b, miR-216a and miR-1296 were putative negative regulators of RASGRP3, GPR160, PRKCH and XAF1, respectively, which were found to be differentially expressed in LCLs during long-term culture in a previous study. Linear regression analysis showed that miR-200a and miR-296-3p correlated with triglyceride and HbA1C levels. HHID00011076 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-155 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 - Downregulation Host Protein C-MYB http://www.ncbi.nlm.nih.gov/gene/4602 Downregulation Immunohistochemistry, Differential expression detection, In silico target prediction, Small RNA cloning, Transfection and luciferase assay, Northern blot, Sequence annotation, MicroRNA blocking assay and western blot, Reverse transcription and semi-quantitative RT?PCR, Statistical analysis. 21062812 microRNA profiling in Epstein-Barr virus-associated B-cell lymphoma. We show that c-MYB is targeted by miR-155 and miR-424.Downregulation of miR-155 and miR-424 was demonstrated by northern blotting.In summary, c-MYB is negatively regulated by both miR-155 and -424. HHID00011077 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-155 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 - Downregulation Host Protein C-SKI http://www.ncbi.nlm.nih.gov/gene/6498 Downregulation Immunohistochemistry, Differential expression detection, In silico target prediction, Small RNA cloning, Transfection and luciferase assay, Northern blot, Sequence annotation, MicroRNA blocking assay and western blot, Reverse transcription and semi-quantitative RT?PCR, Statistical analysis. 21062812 microRNA profiling in Epstein-Barr virus-associated B-cell lymphoma. C-SKI is potentially regulated by miR-155.while SIAH1 is down-modulated by miR-424 and c-SKI is potentially downregulated by miR-155.Downregulation of miR-155 and miR-424 was demonstrated by northern blotting. HHID00011078 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 MC3 cells - Host Protein SPI1(PU.1) http://www.ncbi.nlm.nih.gov/gene/6688 Downregulation Infection and time course, Viral generation, Transient transfection, Chromatin immunoprecipitation assay, Preparation of nuclear extracts and electrophoresis mobility shift assay, Reporter analysis, Western blot analysis, Transient transfection of MC3, Cloning and mutagenesis of BIC/miR-155 promoter, RNA preparation and northern blot. 18940871 Finally,we demonstrate that LMP1-mediated activation of miR-155 in an EBV-negative background correlates with reduction of protein PU.1, which is a possible miR targe. HHID00011079 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-18a(miR-18a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000072 Nasopharyngeal epithelial tissues - Host mRNA DICER1(Dicer1) http://www.ncbi.nlm.nih.gov/gene/23405 Downregulation Luciferase assay. 23097559 Further studies demonstrated that miR-18a negatively regulated Dicer1 by binding to the 3' untranslated regions of Dicer1. HHID00011080 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-200b(miR200b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000342 Epithelial gastric carcinoma AGSB95.8 cells - Host Protein ZEB1 http://www.ncbi.nlm.nih.gov/gene/6935 Downregulation RT-qPCR, Immunoblot analysis, Transient transfection assays, IFS, Assay for infectious EBV, Statistical analysis. 20668090 We show that miR200b and miR429, but not miR200a, can induce EBV-positive cells into lytic replication by downregulating expression of ZEB1 and ZEB2, leading to production of infectious virus. HHID00011081 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-203a(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000283 Epithelial cells Downregulation Host Protein CCNG1 http://www.ncbi.nlm.nih.gov/gene/900 - RNA extraction and RT-PCR, Experiments in nude mice, ISH and immunohistochemical analysis, Design of siRNA and Western blotting, Luciferase reporter assay, Assessment of pathway inhibition, EBV infection and parallel controls, Statistical analysis, Flow cytometry analysis. 22205737 EBV-LMP1 mediated the downregulation of miR-203 at the primary transcript level. E2F3 and CCNG1 were identified as target genes of miR-203.Overexpression of the targets overcame the effects of miR-203 mimics on the cell cycle, and the expression of target genes in tumor models was inhibited by miR-203. HHID00011082 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-203a(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000283 Epithelial cells Downregulation Host Protein E2F3 http://www.ncbi.nlm.nih.gov/gene/1871 - RNA extraction and RT-PCR, Experiments in nude mice, ISH and immunohistochemical analysis, Design of siRNA and Western blotting, Luciferase reporter assay, Assessment of pathway inhibition, EBV infection and parallel controls, Statistical analysis, Flow cytometry analysis. 22205737 EBV-LMP1 mediated the downregulation of miR-203 at the primary transcript level. E2F3 and CCNG1 were identified as target genes of miR-203.Overexpression of the targets overcame the effects of miR-203 mimics on the cell cycle, and the expression of target genes in tumor models was inhibited by miR-203. HHID00011083 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-203b(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0017343 Epithelial cells Downregulation Host Protein CCNG1 http://www.ncbi.nlm.nih.gov/gene/900 - RNA extraction and RT-PCR, Experiments in nude mice, ISH and immunohistochemical analysis, Design of siRNA and Western blotting, Luciferase reporter assay, Assessment of pathway inhibition, EBV infection and parallel controls, Statistical analysis, Flow cytometry analysis. 22205737 EBV-LMP1 mediated the downregulation of miR-203 at the primary transcript level. E2F3 and CCNG1 were identified as target genes of miR-203.Overexpression of the targets overcame the effects of miR-203 mimics on the cell cycle, and the expression of target genes in tumor models was inhibited by miR-203. HHID00011084 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-203b(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0017343 Epithelial cells Downregulation Host Protein E2F3 http://www.ncbi.nlm.nih.gov/gene/1871 - RNA extraction and RT-PCR, Experiments in nude mice, ISH and immunohistochemical analysis, Design of siRNA and Western blotting, Luciferase reporter assay, Assessment of pathway inhibition, EBV infection and parallel controls, Statistical analysis, Flow cytometry analysis. 22205737 EBV-LMP1 mediated the downregulation of miR-203 at the primary transcript level. E2F3 and CCNG1 were identified as target genes of miR-203.Overexpression of the targets overcame the effects of miR-203 mimics on the cell cycle, and the expression of target genes in tumor models was inhibited by miR-203. HHID00011085 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-205(miR-205) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000285 NK/T-cell lymphomas Downregulation Host Protein BCL6 http://www.ncbi.nlm.nih.gov/gene/604 - Small RNA Cloning, qRT-PCR, Western Blotting, Northern Blot, ELISA, Sequence Annotation, Luciferase Assays. 22870299 We show that the proinflammatory cytokine interleukin 1 alpha(IL1A) is a target for miR-142-3p and the oncogenic BCL6 for miR-205.MiR-205 was undetectable in EBV-negative lymphoma and strongly down-regulated in EBV-positive NK/T-cell lymphoma as compared to thymus. HHID00011086 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-216a(miR-216a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000292 Lymphoblastoid cell lines - Host Protein PRKCH http://www.ncbi.nlm.nih.gov/gene/5583 Downregulation miRNA microarray approach with early- (p6) and late-passage (p161) LCLs, Linear regression analysis. 21199010 MicroRNA signatures associated with immortalization of EBV-transformed lymphoblastoid cell lines and their clinical traits. In particular, miR-125b was up-regulated in all the tested late-passage LCLs. miR-99a, miR-125b, miR-216a and miR-1296 were putative negative regulators of RASGRP3, GPR160, PRKCH and XAF1, respectively, which were found to be differentially expressed in LCLs during long-term culture in a previous study. Linear regression analysis showed that miR-200a and miR-296-3p correlated with triglyceride and HbA1C levels. HHID00011087 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-34a(miR-34a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000268 Lymphoblastoid cell lines - Host Protein TP53(P53) http://www.ncbi.nlm.nih.gov/gene/7157 - Growth experiments/Western blotting/Quantitative real-time(qRT) PCR. 22496226 However,one miRNA described as a p53-targeted tumor suppressor, miR-34a, was strongly induced by EBV infection and expressed in many EBV and Kaposi's sarcoma-associated herpesvirus(KSHV)-infected lymphoma cell lines. HHID00011088 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-424 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001446 - Downregulation Host Protein C-MYB http://www.ncbi.nlm.nih.gov/gene/4602 Downregulation Immunohistochemistry, Differential expression detection, In silico target prediction, Small RNA cloning, Transfection and luciferase assay, Northern blot, Sequence annotation, MicroRNA blocking assay and western blot, Reverse transcription and semi-quantitative RT?PCR, Statistical analysis. 21062812 microRNA profiling in Epstein-Barr virus-associated B-cell lymphoma. We show that c-MYB is targeted by miR-155 and miR-424.Downregulation of miR-155 and miR-424 was demonstrated by northern blotting.In summary, c-MYB is negatively regulated by both miR-155 and -424. HHID00011089 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-424 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001446 DLBCL Downregulation Host Protein SIAH1 http://www.ncbi.nlm.nih.gov/gene/6477 Downregulation Immunohistochemistry, Differential expression detection, In silico target prediction, Small RNA cloning, Transfection and luciferase assay, Northern blot, Sequence annotation, MicroRNA blocking assay and western blot, Reverse transcription and semi-quantitative RT?PCR, Statistical analysis. 21062812 microRNA profiling in Epstein-Barr virus-associated B-cell lymphoma. The tumor suppressor SIAH1 is targeted by miR-424 .Downregulation of miR-155 and miR-424 was demonstrated by northern blotting.This protein blot confirms the experiments that showed a downregulation of the SIAH1-3'UTR by miR-424. HHID00011090 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-429(miR429) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001641 Epithelial gastric carcinoma AGSB95.8 cells - Host Protein ZEB2 http://www.ncbi.nlm.nih.gov/gene/9839 Downregulation RT-qPCR, Immunoblot analysis, Transient transfection assays, IFS, Assay for infectious EBV, Statistical analysis. 20668090 We show that miR200b and miR429, but not miR200a, can induce EBV-positive cells into lytic replication by downregulating expression of ZEB1 and ZEB2, leading to production of infectious virus. HHID00011091 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-99a(miR-99a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000101 Lymphoblastoid cell lines - Host Protein RASGRP3 http://www.ncbi.nlm.nih.gov/gene/25780 Downregulation miRNA microarray approach with early- (p6) and late-passage (p161) LCLs, Linear regression analysis. 21199010 MicroRNA signatures associated with immortalization of EBV-transformed lymphoblastoid cell lines and their clinical traits. In particular, miR-125b was up-regulated in all the tested late-passage LCLs. miR-99a, miR-125b, miR-216a and miR-1296 were putative negative regulators of RASGRP3, GPR160, PRKCH and XAF1, respectively, which were found to be differentially expressed in LCLs during long-term culture in a previous study. Linear regression analysis showed that miR-200a and miR-296-3p correlated with triglyceride and HbA1C levels. HHID00011092 Gallid herpesvirus 2(GaHV-2) Gallus gallus Host miRNA gga-mir-21(gga-miR-21) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004994 Virulent strain(RB-1B),vaccine strain(CVI988). Upregulation Host Protein PDCD4 http://www.ncbi.nlm.nih.gov/gene/374191 - Luciferase assays. 23055556 GaHV-2 encodes a basic leucine zipper (bZIP) protein of the AP-1 family, Meq. We show here that the viral oncoprotein Meq binds to this promoter, thereby transactivating gga-miR-21 expression. We confirmed that this miRNA targets chicken programmed death cell 4(PDCD4) and promotes tumor cell growth and apoptosis escape. HHID00011093 Hendra virus Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Blood Upregulation Host Protein RNF11 http://www.ncbi.nlm.nih.gov/gene/26994 Downregulation - 23345523 In this work, we demonstrate that Hendra virus makes use of a microRNA (miRNA) designated miR-146a, an NFKB-responsive miRNA upregulated by several innate immune ligands, to favor its replicationIn silico analysis of miR-146a targets identified ring finger protein(RNF)11, a member of the A20 ubiquitin editing complex that negatively regulates NFKB activity, as a novel component of Hendra virus replication;silencing of RNF11 promotes Hendra virus replication in vitro. HHID00011094 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7c(let-7c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000064 liver Downregulation Host Protein BCL2L1(Bcl-xl) http://www.ncbi.nlm.nih.gov/gene/598 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011095 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7c(let-7c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000064 liver Downregulation Host Protein MCL1(Mcl-1) http://www.ncbi.nlm.nih.gov/gene/4170 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011096 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7c(let-7c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000064 liver Downregulation Host Protein MYC(c-Myc) http://www.ncbi.nlm.nih.gov/gene/4609 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011097 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7g(let-7g) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000433 liver Downregulation Host Protein BCL2L1(Bcl-xl) http://www.ncbi.nlm.nih.gov/gene/598 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011098 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7g(let-7g) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000433 liver Downregulation Host Protein COL1A2 http://www.ncbi.nlm.nih.gov/gene/1278 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011099 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7g(let-7g) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000433 liver Downregulation Host Protein MYC(c-Myc) http://www.ncbi.nlm.nih.gov/gene/4609 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011100 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7i(let-7i) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000434 HCC cells - Host Protein CD59 http://www.ncbi.nlm.nih.gov/gene/966 Upregulation Complement-dependent cytotoxicity. 22425745 HBx up-regulates CD59 by let-7i at the post-transcriptional level, contributing to escape of HCC cells from complement-dependent cytotoxicity. HHID00011101 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-miR-199a-3p(miR-199a-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000232 liver Downregulation Host Protein CD44 http://www.ncbi.nlm.nih.gov/gene/960 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011102 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-miR-199a-3p(miR-199a-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000232 liver Downregulation Host Protein MTOR http://www.ncbi.nlm.nih.gov/gene/2475 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011103 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-miR-199a-3p(miR-199a-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000232 liver Downregulation Host Protein PAK4 http://www.ncbi.nlm.nih.gov/gene/10298 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011104 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-miR-199a-5p(miR-199a-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000231 HCC and adjacent non-tumor tissues - Host Protein CLTC(CHC) http://www.ncbi.nlm.nih.gov/gene/1213 Upregulation Western blotting and luciferase assay. 23082062 Identification of deregulated miRNAs and their targets in hepatitis B virus-associated hepatocellular carcinoma. MiR-519a and ribosomal protein S6 kinase polypeptide 3(RPS6KA3) were predicted as the most significant candidates by miRNA-mRNA network. In addition, cyclin D3(CCND3) and clathrin heavy chain(CHC), usually up-regulated in HCC tissues, were validated as the direct target of miR-138 and miR-199a-5p, respectively. HHID00011105 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-miR-338-3p(miR-338-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000763 LO2/HBx-d382 cells - Host mRNA CCND1(CyclinD1) http://www.ncbi.nlm.nih.gov/gene/595 Downregulation Western Blot Analysis, Quantitative Real-time PCR (qRT-PCR) Analysis, Gene Sequence Analysis and Primer Design, Statistical Analysis, EdU Assay, Soft Agar Colony Formation Assay, Cell Cycle Assay, Cell Transfection, RT-PCR Analysis. 22912826 miR-338-3p expression inhibited cell proliferation in LO2/HBx-d382 cells (and LO2/HBx cells), and also negatively regulated CyclinD1 protein expression. Of the two putative miR-338-3p binding sites in the CyclinD1-3'UTR region, the effect of miR-338-3p on the second binding site (nt 2397-2403) was required for the inhibition. HHID00011106 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-1-1(miR-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000651 Hepatoma cells - Host Protein E2F5 http://www.ncbi.nlm.nih.gov/gene/1875 Upregulation Western Blot Analysis, Microarray Analysis, Real-Time RT-PCR Assay, Vector Construction and Luciferase Reporter Assay, Cell Proliferation and Cell Cycle Analysis, Statistical Analysis. 21520166 It was noted that microRNA-1 (miR-1) transfection resulted in a marked increase of HBV replication, accompanied with up-regulated HBV transcription, antigen expression, and progeny secretion. However, bioinformatics and luciferase reporter analysis suggested that miR-1 may not target the HBV genome directly but regulate the expression of host genes to enhance HBV replication. Further studies showed that miR-1 was able to enhance the HBV core promoter transcription activity by augmenting farnesoid X receptor alpha expression. In addition, miR-1 arrested the cell cycle at the G(1) phase and inhibited cell proliferation by targeting histone deacetylase 4 and E2F transcription factor 5. HHID00011107 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-1-1(miR-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000651 Hepatoma cells - Host Protein FXRA # Upregulation Western Blot Analysis, Microarray Analysis, Real-Time RT-PCR Assay, Vector Construction and Luciferase Reporter Assay, Cell Proliferation and Cell Cycle Analysis, Statistical Analysis. 21520166 It was noted that microRNA-1 (miR-1) transfection resulted in a marked increase of HBV replication, accompanied with up-regulated HBV transcription, antigen expression, and progeny secretion. However, bioinformatics and luciferase reporter analysis suggested that miR-1 may not target the HBV genome directly but regulate the expression of host genes to enhance HBV replication. Further studies showed that miR-1 was able to enhance the HBV core promoter transcription activity by augmenting farnesoid X receptor alpha expression. In addition, miR-1 arrested the cell cycle at the G(1) phase and inhibited cell proliferation by targeting histone deacetylase 4 and E2F transcription factor 5. HHID00011108 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-1-1(miR-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000651 Hepatoma cells - Host Protein HDAC4 http://www.ncbi.nlm.nih.gov/gene/9759 Upregulation Western Blot Analysis, Microarray Analysis, Real-Time RT-PCR Assay, Vector Construction and Luciferase Reporter Assay, Cell Proliferation and Cell Cycle Analysis, Statistical Analysis. 21520166 It was noted that microRNA-1 (miR-1) transfection resulted in a marked increase of HBV replication, accompanied with up-regulated HBV transcription, antigen expression, and progeny secretion. However, bioinformatics and luciferase reporter analysis suggested that miR-1 may not target the HBV genome directly but regulate the expression of host genes to enhance HBV replication. Further studies showed that miR-1 was able to enhance the HBV core promoter transcription activity by augmenting farnesoid X receptor alpha expression. In addition, miR-1 arrested the cell cycle at the G(1) phase and inhibited cell proliferation by targeting histone deacetylase 4 and E2F transcription factor 5. HHID00011109 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-101(miR-101) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000103 Hepatic cells Downregulation Host Protein DNMT3A http://www.ncbi.nlm.nih.gov/gene/1788 - 3'-UTR reporter assay. 23124077 miR-101 is down-regulated by the hepatitis B virus x protein and induces aberrant DNA methylation by targeting DNA methyltransferase 3A.The direct target of miR-101, DNA methyltransferase 3A(DNMT3A), was identified in silico and validated using a 3'-UTR reporter assay. HHID00011110 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 Hepatoma cells Upregulation Host Protein HO-1 http://www.ncbi.nlm.nih.gov/gene/3162 Downregulation Immunoblot analysis, Detection of HBsAg and HBeAg, RNA extraction and real-time PCR, Statistical analysis. 20633528 miR-122-induced down-regulation of HO-1 negatively affects miR-122-mediated suppression of HBV. We further found that the down-regulation of Heme oxygenase-1 (HO-1) by miR-122 plays a negative role in the miR-122-mediated inhibition of viral expression. HHID00011111 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 Liver tissues Downregulation Host Protein CCNG1(cyclin G1) http://www.ncbi.nlm.nih.gov/gene/900 Upregulation A luciferase reporter system, and electrophoretic mobility shift assay, Overexpression and knockdown studies coimmunoprecipitation. 22105316 We also observed that cyclin G(1) expression was up-regulated in HBV-infected patients, and cyclin G(1) levels were inversely associated with miR-122 expression in liver tissues. HHID00011112 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 liver Downregulation Host Protein PBF http://www.ncbi.nlm.nih.gov/gene/754 Upregulation Luciferase assays. 23221562 We next identified pituitary tumor-transforming gene 1(PTTG1) binding factor (PBF) as a target of miR-122 and demonstrated that HBV replication causes an obvious increase in PBF levels. HHID00011113 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 liver Downregulation Host Protein cyclin G1 http://www.ncbi.nlm.nih.gov/gene/595 Upregulation Luciferase assays. 23221562 Loss of miR-122 expression in patients with hepatitis B enhances hepatitis B Virus replication through cyclin G1-modulated P53 activity. HHID00011114 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 liver Downregulation Host Protein ADAM10 http://www.ncbi.nlm.nih.gov/gene/102 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011115 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 liver Downregulation Host Protein ADAM17 http://www.ncbi.nlm.nih.gov/gene/6868 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011116 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 liver Downregulation Host Protein BCL2L2(BCL-W) http://www.ncbi.nlm.nih.gov/gene/599 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011117 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 liver Downregulation Host Protein CCNG1(cyclin G1) http://www.ncbi.nlm.nih.gov/gene/900 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011118 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 liver Downregulation Host Protein CUX1 http://www.ncbi.nlm.nih.gov/gene/1523 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011119 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 liver Downregulation Host Protein IGF1R(Igf1R) http://www.ncbi.nlm.nih.gov/gene/3480 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011120 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 liver Downregulation Host Protein PEG10 http://www.ncbi.nlm.nih.gov/gene/23089 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011121 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 liver Downregulation Host Protein RHOA(RhoA) http://www.ncbi.nlm.nih.gov/gene/387 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011122 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 liver Downregulation Host Protein SRF http://www.ncbi.nlm.nih.gov/gene/6722 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011123 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 liver Downregulation Host Protein VIM(Vimentin) http://www.ncbi.nlm.nih.gov/gene/7431 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011124 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-124-1(miR-124) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000443 liver Downregulation Host Protein CDK6 http://www.ncbi.nlm.nih.gov/gene/1021 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011125 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-124-1(miR-124) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000443 liver Downregulation Host Protein IL-6R http://www.ncbi.nlm.nih.gov/gene/3570 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011126 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-124-1(miR-124) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000443 liver Downregulation Host Protein IQGAP1 http://www.ncbi.nlm.nih.gov/gene/8826 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011127 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-124-1(miR-124) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000443 liver Downregulation Host Protein SMYD3 http://www.ncbi.nlm.nih.gov/gene/64754 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011128 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-124-1(miR-124) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000443 liver Downregulation Host Protein VIM(Vimentin) http://www.ncbi.nlm.nih.gov/gene/7431 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011129 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-138(miR-138) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000476 HCC and adjacent non-tumor tissues - Host Protein CCND3 http://www.ncbi.nlm.nih.gov/gene/896 Upregulation Western blotting and luciferase assay. 23082062 Identification of deregulated miRNAs and their targets in hepatitis B virus-associated hepatocellular carcinoma. MiR-519a and ribosomal protein S6 kinase polypeptide 3(RPS6KA3) were predicted as the most significant candidates by miRNA-mRNA network. In addition, cyclin D3(CCND3) and clathrin heavy chain(CHC), usually up-regulated in HCC tissues, were validated as the direct target of miR-138 and miR-199a-5p, respectively. HHID00011130 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-141(miR-141) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000457 HepG2 cells - Host Protein PPARA http://www.ncbi.nlm.nih.gov/gene/5465 Downregulation Promoter functional analysis. 22479552 Our results suggest that miR-141 suppressed HBV replication by reducing HBV promoter activities by down-regulating PPARA. HHID00011131 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-143(miR-143) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000459 Hepatocellular Upregulation Host Protein FNDC3B http://www.ncbi.nlm.nih.gov/gene/64778 Downregulation Western Blot Analysis, Luciferase Reporter Assay, Chromatin Immunoprecipitation Assay, Reverse Transcription Reaction and Quantitative Real-Time PCR. 19472311 Additionally,fibronectin type III domain containing 3B(FNDC3B), which regulates cell motility, was identified as the direct and functional target of miR-143 both in vivo and in vitro. Up-regulation of miR-143 expression transcribed by NF-kappaB in HBV-HCC promotes cancer cell invasion/migration and tumor metastasis by repression of FNDC3B expression. . HHID00011132 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-143(miR-143) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000459 Hepatocellular Upregulation Host Protein FNDC3B http://www.ncbi.nlm.nih.gov/gene/64778 Downregulation Western Blot Analysis, Transwell Invasion Assay, Flow Cytometric Analysis, Luciferase Reporter Assay, miRNA microarray, Chromatin Immunoprecipitation Assay, Reverse Transcription Reaction and Quantitative Real-Time PCR. 19472311 Up-regulation of miR-143 expression transcribed by NF-kappaB in HBV-HCC promotes cancer cell invasion/migration and tumor metastasis by repression of FNDC3B expression. HHID00011133 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-148a(miR-148a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000253 HepG2 and Hep3B cells - Host Protein PTEN http://www.ncbi.nlm.nih.gov/gene/5728 Downregulation Tumorigenesis and Cell Migration Assays, qRT-PCR/Western Blotting/Anchorage Independent Growth. 22496917 Role of miR-148a in hepatitis B associated hepatocellular carcinoma. Introduction of anti-miR-148a increased PTEN protein and mRNA expression, suggesting that PTEN was targeted by miR-148a. HHID00011134 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-152(miR-152) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000462 Liver cells Downregulation Host Protein DNMT1 http://www.ncbi.nlm.nih.gov/gene/1786 Downregulation Luciferase Reporter Assa, Western Blot Analysi, Reverse-Transcription Reaction and Quantitative Real-Time PCR, Global DNA Methylation (GDM) Studies, DNA Extraction and Bisul?te Treatmen. 20578129 Our findings suggest that miR-152 is frequently down-regulated and regulates DNMT1 in HBV-related HCC. HHID00011135 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 HepG2 - Host Protein SOCS1 http://www.ncbi.nlm.nih.gov/gene/8651 Downregulation Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) assay, Quantitative reverse transcription-PCR assay, Statistical analyzes, Cell proliferation assay, Western blot. 21762537 MiR-155 enhances innate antiviral immunity through promoting JAK/STAT signaling pathway by targeting SOCS1, and mildly inhibits HBV infection in human hepatoma cells. HHID00011136 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-16(miR-16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000070 liver Downregulation Host Protein BCL2 http://www.ncbi.nlm.nih.gov/gene/596 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011137 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-181a-1(miR-181a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000289 Liver cells Upregulation Host Protein HLA-A http://www.ncbi.nlm.nih.gov/gene/3105 Downregulation Genotypic characterization of human leukocyte antigen (HLA), Computational prediction of miRNA targets, Northern blotting analysis, Flow cytometric (FCM) analysis, miRNA microarray analysis. 19187610 Altered expression profiles of microRNAs in a stable hepatitis B virus-expressing cell line. The 3'-UTR of HLA-A gene had one partially complementary site for miR-181a and miR-181a might down-regulate the expression of HLA-A. HHID00011138 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-197(miR-197) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000239 THP-1 cells - Host Protein Interleukin-18(IL-18) http://www.ncbi.nlm.nih.gov/gene/3606 - Predicted. 23710316 miR-197 Expression in Peripheral Blood Mononuclear Cells from Hepatitis B Virus-Infected Patients. IL-18,a key regulator in inflammation and immunity, was inversely correlated with miR-197 levels. Bioinformatic analysis indicated that IL-18 was a target of miR-197. Exogenous expression of miR-197 could significantly repress IL-18 expression at both the mRNA and protein levels in THP-1 cells. HHID00011139 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-21(miR-21) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000077 liver Upregulation Host Protein MMP9 http://www.ncbi.nlm.nih.gov/gene/4318 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011140 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-21(miR-21) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000077 liver Upregulation Host Protein PTEN http://www.ncbi.nlm.nih.gov/gene/5728 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011141 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-216a(miR-216a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000292 Liver cells - Host Protein CADM1(TSLC1) http://www.ncbi.nlm.nih.gov/gene/23705 Downregulation Chromatin immunoprecipitation (ChIP), Pri-miR-216a 5'-Promoter Region Driven Luciferase Reporter Constructs, 5'RACE Analysis. 22392644 we demonstrated that pri-miR-216a is activated transcriptionally by the androgen pathway in a ligand-dependent manner and is further enhanced by the hepatitis B virus X protein. One target of miR-216a was shown to be the tumor suppressor in lung cancer-1 gene(TSLC1) messenger RNA(mRNA) through the three target sites at its 3' untranslated region. HHID00011142 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-22(miR-22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000078 Hepatocellular carcinoma(HCC) cell lines Downregulation Host Protein CDKN1A http://www.ncbi.nlm.nih.gov/gene/5063 - - 23582783 MicroRNA-22 is down-regulated in hepatitis B virus-related hepatocellular carcinoma. Cyclin-dependent kinase inhibitor 1A(CDKN1A) was found to be inversely correlated with miR-22 and was identified as a target of miR-22. HHID00011143 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-221(miR-221) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000298 liver Upregulation Host Protein CDKN1B(CDKN1B/p27) http://www.ncbi.nlm.nih.gov/gene/1027 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011144 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-221(miR-221) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000298 liver Upregulation Host Protein CDKN1C(CDKN1C/p57) http://www.ncbi.nlm.nih.gov/gene/1028 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011145 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-221(miR-221) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000298 liver Upregulation Host Protein DDIT4 http://www.ncbi.nlm.nih.gov/gene/54541 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011146 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-222(miR-222) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000299 liver Upregulation Host Protein PPP2R2A http://www.ncbi.nlm.nih.gov/gene/5520 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011147 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-26a-1(miR-26a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000083 liver Downregulation Host Protein CCND2(cyclin D2) http://www.ncbi.nlm.nih.gov/gene/894 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011148 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-26a-1(miR-26a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000083 liver Downregulation Host Protein CCNE2(cyclin E2) http://www.ncbi.nlm.nih.gov/gene/9134 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011149 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-29a(miR-29) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000087 liver Downregulation Host Protein BCL2 http://www.ncbi.nlm.nih.gov/gene/596 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011150 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-29a(miR-29) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000087 liver Downregulation Host Protein MCL1(Mcl-1) http://www.ncbi.nlm.nih.gov/gene/4170 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011151 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-29a(miR-29a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000087 HepG2 cells - Host Protein PTEN http://www.ncbi.nlm.nih.gov/gene/5728 Upregulation RNA interference, qRT-PCR, Wound healing assay, RNA extraction, Construction of plasmids, Modified boyden's chamber assay, Dual-luciferase reporter gene assay, Western blot analysis, Statistical analysis. 21573166 Moreover,we identified PTEN was one of the target genes of miR-29a in HepG2 cells.Moreover, our data showed that the modulation of Akt phosphorylation, a downstream factor of PTEN, was involved in the cell migration enhanced by miR-29a, suggesting that miR-29a is responsible for the cell migration through its target gene PTEN. Thus, we conclude that miR-29a is involved in the regulation of migration of hepatoma cells mediated by HBx through PTEN in cell culture model. HHID00011152 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-29a(miR-29a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000087 Hepatoma cells - Host Protein PTEN http://www.ncbi.nlm.nih.gov/gene/5728 Downregulation Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 Phosphataseand tensin homolog(PTEN), a crucial tumor suppressor, has been identified as one of the target genes of miR-29a. Overexpression of miR-29a in hepatoma cells results in downregulation of PTEN and increases serine phosphorylation of its downstream component. HHID00011153 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-29a(miR-29a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000087 liver Downregulation Host Protein PPM1D http://www.ncbi.nlm.nih.gov/gene/8493 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011154 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-29a(miR-29a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000087 liver Downregulation Host Protein PTEN http://www.ncbi.nlm.nih.gov/gene/5728 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011155 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-29c(miR-29c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000735 HepG2.2.15 cells Downregulation Host Protein TNFAIP3 http://www.ncbi.nlm.nih.gov/gene/7128 Downregulation Apoptosis assay, qRT-PCR, HBsAg and HBeAg assay, transfection, HBV-DNA assay, western blot analysis, luciferase reporter assay, bioinformatics analysis, cell proliferation assay. 21763284 Here, we report that miR-29c was significantly downregulated in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) cell lines as well as in clinical tissues compared with their corresponding controls.Tumor necrosis factor alpha-induced protein 3 (TNFAIP3), a key regulator in inflammation and immunity, was found to be inversely correlated with miR-29c levels and was identified as a target of miR-29c. Overexpression of miR-29c in HepG2.2.15 cells effectively suppressed TNFAIP3 expression and HBV DNA replication as well as inhibited cell proliferation and induced apoptosis. HHID00011156 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-34a(miR-34a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000268 liver Downregulation Host Protein ALDH2 http://www.ncbi.nlm.nih.gov/gene/217 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011157 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-34a(miR-34a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000268 liver Downregulation Host Protein GFAP http://www.ncbi.nlm.nih.gov/gene/2670 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011158 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-34a(miR-34a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000268 liver Downregulation Host Protein LMNA http://www.ncbi.nlm.nih.gov/gene/4000 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011159 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-34a(miR-34a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000268 liver Downregulation Host Protein LOC100129335 http://www.ncbi.nlm.nih.gov/gene/100129335 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011160 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-34a(miR-34a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000268 liver Downregulation Host Protein MACF1 http://www.ncbi.nlm.nih.gov/gene/23499 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011161 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-34a(miR-34a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000268 liver Downregulation Host Protein MET(c-Met) http://www.ncbi.nlm.nih.gov/gene/4233 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011162 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-372(miR-372) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000780 HepG2.2.15 cells Upregulation Host Protein NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - Western blotting and luciferase reporter assays. 21608007 Further,nuclear factor I/B(NFIB) was identified to be a direct functional target of miRs-372/373 by in silico algorithms and this was subsequently confirmed by western blotting and luciferase reporter assays.Our study revealed that miRNA(miRs-372/373) can promote HBV expression through a pathway involving the transcription factor(NFIB). . HHID00011163 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-373(miR-373) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000781 HepG2.2.15 cells Upregulation Host Protein NFIB http://www.ncbi.nlm.nih.gov/gene/4781 - Western blotting and luciferase reporter assays. 21608007 Further,nuclear factor I/B(NFIB) was identified to be a direct functional target of miRs-372/373 by in silico algorithms and this was subsequently confirmed by western blotting and luciferase reporter assays.Our study revealed that miRNA(miRs-372/373) can promote HBV expression through a pathway involving the transcription factor(NFIB). . HHID00011164 Hepatitis B virus(HBV) Mus musculus Host miRNA mmu-mir-148a(miR-148a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000550 Hepatocellular carcinoma Downregulation Host Protein Tnfrsf12a(HPIP) http://www.ncbi.nlm.nih.gov/gene/27279 - Luciferase reporter assay, RT-PCR, immunohistochemistry. 23321675 Here, we report that miR-148a is repressed by hepatitis B virus (HBV) X protein (HBx) to promote cancer growth and metastasis in a mouse model of hepatocellular carcinoma (HCC). Hematopoietic pre-B cell leukemia transcription factor-interacting protein (HPIP) is an important regulator of cancer cell growth. We used miRNA target prediction programs to identify miR-148a as a regulator of HPIP. Expression of miR-148a in hepatoma cells reduced HPIP expression, leading to repression of AKT and ERK and subsequent inhibition of mTOR through the AKT/ERK/FOXO4/ATF5 pathway. HHID00011165 Hepatitis B virus(HBV) Mus musculus Host miRNA mmu-mir-152(miR-152) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000174 HepG2, HepG2.2.15 and LO2 cell lines Downregulation Host Protein Dnmt1(DNMT1) http://www.ncbi.nlm.nih.gov/gene/13433 Upregulation - 23108868 miR-152 is frequently downregulated in HBV-HCC mice and the HepG2.2.15 cell line. miR-152 expression is inversely correlated with DNA methyltransferase (DNMT)1 expression in HBV-HCC as well as in HepG2, HepG2.2.15 and LO2 cell lines. Upregulation of DNMT1 as a result of miR-152 downregulation has been observed during HCC development. HHID00011166 Hepatitis C virus(HCV) Homo sapiens Host miRNA has-mir-141(miR-141) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000457 Primary Hepatocyte Coculture Upregulation Host Protein DLC1(DLC-1) http://www.ncbi.nlm.nih.gov/gene/10395 Downregulation RNA Isolation, Array-Based Klenow Enzyme Assay, Statistical Analysis and Reproducibility., Luciferase Reporter Assay, western Blot Analysis of DLC-1 Protein, fluorescein Isothiocyanate, miRNA Detection by Way of RNA-Primed, and Quan-titative PCR, Reverse-Transcription. 20967756 MicroRNA miR-141 that targets DLC-1 was accentuated in cells infected with HCV genotypes 1a, 1b, and 2a. We present several lines of evidence that efficient HCV replication requires miR-141-mediated suppression of DLC-1. An increase in miR-141 correlated with the inhibition of DLC-1 protein in HCV-infected cells. HHID00011167 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-let-7c(Let-7c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000064 Huh-7 cells,HepG2 cells. - Host Protein BCL2L1(Bcl-xl) http://www.ncbi.nlm.nih.gov/gene/598 Downregulation Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 Let-7cand let-7g miRNAs have been shown to regulate Bcl-xl. HHID00011168 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-let-7g(let-7g) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000433 Huh-7 cells,HepG2 cells. - Host Protein BCL2L1(Bcl-xl) http://www.ncbi.nlm.nih.gov/gene/598 Downregulation Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 Let-7cand let-7g miRNAs have been shown to regulate Bcl-xl. HHID00011169 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-miR-193b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003137 Hep-394 cells Upregulation Host Protein Mcl-1 http://www.ncbi.nlm.nih.gov/gene/4170 Downregulation Predicted. 20103677 Hepatitis C virus proteins modulate microRNA expression and chemosensitivity in malignant hepatocytes.Of these, miR-193b was over-expressed by 5-fold in Hep-394 cells. miR-193b was predicted to target Mcl-1, an anti-apoptotic protein that can modulate the response to sorafenib. The expression of Mcl-1 expression was decreased and basal caspase-3/7 activity and PARP cleavage were increased in Hep-394 cells compared to controls. Moreover, transfection with precursors to miR-193b decreased both Mcl-1 expression and the IC50 to sorafenib. HHID00011170 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-1-1(miR-1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000651 - Upregulation Host Protein FOXP1(FoxP1) http://www.ncbi.nlm.nih.gov/gene/27086 Downregulation Western Blot Analysis, luciferase Reporter assay. 23108868 Therapeutic intervention with hypomethylating agents could inhibit HCC cell growth by increasing miR-1-1 expression to inhibit expression of its two downstream oncogenes, MET(MNNG HOS transforming gene) and FoxP1(Forkhead box protein P1). HHID00011171 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-1-1(miR-1-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000651 - Upregulation Host Protein MET http://www.ncbi.nlm.nih.gov/gene/4233 Downregulation Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 Therapeuticintervention with hypomethylating agents could inhibit HCC cell growth by increasing miR-1-1 expression to inhibit expression of its two downstream oncogenes, MET(MNNG HOS transforming gene) and FoxP1(Forkhead box protein P1). HHID00011172 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-122 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 Huh-7 Downregulation Host Protein HO-1 http://www.ncbi.nlm.nih.gov/gene/3162 Upregulation Quantitative RT-PCR, Statistical analyses, Western Blot. 17919492 Down-regulation of HCV replication using an antagomir targeted to miR-122 is effective, specific, and selective. Increasing HO-1, by silencing the Bach1 gene or by treatment with cobalt protoporphyrin or heme, decreases HCV replication. Thus, miR-122 plays an important role in the regulation of HCV replication and HO-1/Bach1 expression in hepatocytes. Down-regulation of miR-122 and up-regulation of HO-1 may be new strategies for anti-HCV intervention and cytoprotection. HHID00011173 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 - - Host Protein CCNT1(Cyclin T1) http://www.ncbi.nlm.nih.gov/gene/904 - Real-time quantitative polymerase chain reaction, Western blotting, electrophoretic mobility shift assay, and confocal microscopy were used for experimental analysis. 23126531 We show for the first time that Cyclin G1, a miR-122 target gene, has regulatory effects on HCV replication and that alcohol increases HCV replication by regulating miR-122 and Cyclin G1. HHID00011174 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 - Downregulation Host Protein IFNbeta http://www.ncbi.nlm.nih.gov/gene/3456 - RNA extraction, miRNA array analysis, Real-time PCR. 17943132 In addition, we demonstrate that IFNbeta treatment leads to a significant reduction in the expression of the liver-specific miR-122, an miRNA that has been previously shown to be essential for HCV replication. HHID00011175 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 HCV J6/JFH1 infected Huh7.5 cells Upregulation Host Protein HSP90AA1 http://www.ncbi.nlm.nih.gov/gene/3320 - Real Time Reverse Transcription Polymerase Chain Reaction. 22898980 Overexpression of GW182 significantly increased HCV RNA and protein expression in HCV J6/JFH1 infected Huh7.5 cells. Furthermore, GW182 colocalized and coimmunoprecipitated with heat shock protein 90 (HSP90), which increased upon alcohol exposure with and without HCV infection and enhanced HCV gene expression. The use of an HSP90 inhibitor or knockdown of HSP90 decreased GW182 and miR-122 expression and significantly reduced HCV replication. HHID00011176 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 HCV J6/JFH1 infected Huh7.5 cells Upregulation Host Protein HSP90AB1 http://www.ncbi.nlm.nih.gov/gene/3326 - Real Time Reverse Transcription Polymerase Chain Reaction. 22898980 Overexpression of GW182 significantly increased HCV RNA and protein expression in HCV J6/JFH1 infected Huh7.5 cells. Furthermore, GW182 colocalized and coimmunoprecipitated with heat shock protein 90 (HSP90), which increased upon alcohol exposure with and without HCV infection and enhanced HCV gene expression. The use of an HSP90 inhibitor or knockdown of HSP90 decreased GW182 and miR-122 expression and significantly reduced HCV replication. HHID00011177 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 HCV J6/JFH1 infected Huh7.5 cells Upregulation Host Protein HSP90B1 http://www.ncbi.nlm.nih.gov/gene/7184 - Real Time Reverse Transcription Polymerase Chain Reaction. 22898980 Overexpression of GW182 significantly increased HCV RNA and protein expression in HCV J6/JFH1 infected Huh7.5 cells. Furthermore, GW182 colocalized and coimmunoprecipitated with heat shock protein 90 (HSP90), which increased upon alcohol exposure with and without HCV infection and enhanced HCV gene expression. The use of an HSP90 inhibitor or knockdown of HSP90 decreased GW182 and miR-122 expression and significantly reduced HCV replication. HHID00011178 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 HepG2.2.15 - Host Protein CCND1(cyclin G1) http://www.ncbi.nlm.nih.gov/gene/595 Downregulation HBsAg and HBeAg assay, Cell viability assay, Western blot analysis, Cell transfection, qPCR, RT-PCR. 21725618 However, recent evidence shows that miR-122 decreases HBV replication through the inhibitory effect of p53 on HBV transcription, and consequently it acts as a tumor-suppressor through both a decrease in HBV replication and by directly targeting cyclin G1, as well as Wnt/beta-catenin, and NDRG3 pathways. HHID00011179 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 HepG2.2.15 - Host Protein CTNNBIP1(beta-catenin) http://www.ncbi.nlm.nih.gov/gene/56998 Downregulation HBsAg and HBeAg assay, Cell viability assay, Western blot analysis, Cell transfection, qPCR, RT-PCR. 21725618 However, recent evidence shows that miR-122 decreases HBV replication through the inhibitory effect of p53 on HBV transcription, and consequently it acts as a tumor-suppressor through both a decrease in HBV replication and by directly targeting cyclin G1, as well as Wnt/beta-catenin, and NDRG3 pathways. HHID00011180 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 HepG2.2.15 - Host Protein NDRG3 http://www.ncbi.nlm.nih.gov/gene/57446 Downregulation HBsAg and HBeAg assay, Cell viability assay, Western blot analysis, Cell transfection, qPCR, RT-PCR. 21725618 However, recent evidence shows that miR-122 decreases HBV replication through the inhibitory effect of p53 on HBV transcription, and consequently it acts as a tumor-suppressor through both a decrease in HBV replication and by directly targeting cyclin G1, as well as Wnt/beta-catenin, and NDRG3 pathways. HHID00011181 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 HepG2.2.15 - Host Protein TP53(p53) http://www.ncbi.nlm.nih.gov/gene/7157 Downregulation HBsAg and HBeAg assay, Cell viability assay, Western blot analysis, Cell transfection, qPCR, RT-PCR. 21725618 However, recent evidence shows that miR-122 decreases HBV replication through the inhibitory effect of p53 on HBV transcription, and consequently it acts as a tumor-suppressor through both a decrease in HBV replication and by directly targeting cyclin G1, as well as Wnt/beta-catenin, and NDRG3 pathways. HHID00011182 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 Liver - Host Protein Ago2 http://www.ncbi.nlm.nih.gov/gene/27161 - Immunoprecipitations, reporter assays, RNA decay assay, western blots. 23405269 MicroRNA-122 dependent binding of Ago2 protein to hepatitis C virus RNA is associated with enhanced RNA stability and translation stimulation. Here,we show that Argonaute(Ago) 2 protein binds to the HCV 5'-UTR in a miR-122-dependent manner, whereas the HCV 3'-UTR does not bind Ago2. HHID00011183 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 Liver cells - Host Protein TP53(P53) http://www.ncbi.nlm.nih.gov/gene/7157 Downregulation And electrophoretic mobility shift assay, a luciferase reporter system, coimmunoprecipitation. 22105316 Using coimmunoprecipitation, a luciferase reporter system, and electrophoretic mobility shift assay, we further demonstrated that cyclin G(1) specifically interacted with p53, and this interaction blocked the specific binding of p53 to HBV enhancer elements and simultaneously abrogated p53-mediated inhibition of HBV transcription. Finally, we show that miR-122 suppressed HBV replication in p53 wildtype cells but not in null isogenic cells. HHID00011184 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-130a(miR-130a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000448 Hepatocytes and liver biopsy Upregulation Host Protein IFITM1 http://www.ncbi.nlm.nih.gov/gene/8519 Downregulation Knockdown. 22787204 Introduction of anti-miR-130a in hepatocytes increased IFITM1 expression. Hepatocytes stably expressing IFITM1 reduced HCV replication. Together, these results suggested that HCV infection of hepatocytes upregulates miR-130a and that use of anti-miR-130a may have potential for restriction of HCV replication. HHID00011185 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-130a(miR-130a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000448 Huh7.5 cells Downregulation Host mRNA C-Met http://www.ncbi.nlm.nih.gov/gene/4233 Downregulation Predicted. 23418453 Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-alpha treatment.Our data suggests that, in addition to possible antitumor effects, treatment of HCV-infected Huh7.5 cells with IFN-α upregulates miR-130a/301 thereby reducing c-Met expression and HCV pathogenesis. HHID00011186 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-141(miR-141) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000457 - - Host Protein DLC1(DLC-1) http://www.ncbi.nlm.nih.gov/gene/10395 Downregulation Luciferase Reporter Assay. 23108868 Anincrease in miR-141 is often associated with decreased expression of DLC-1(deleted in liver cancer 1), a tumor suppressor gene frequently deleted in HCC and other solid human tumors [67]. HCV-infected hepatocytes show enhanced proliferation that could be mitigated by overexpression of DLC-1, indicating that miR-141 might also promote HCV-induced tumorigenesis. HHID00011187 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-141(miR-141) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000457 Liver cells Upregulation Host Protein DLC1(DLC-1) http://www.ncbi.nlm.nih.gov/gene/10395 Downregulation Array-Based Klenow Enzyme Assay, MiRNA Detection by RNA-Primed, luciferase Reporter Assay. 22359297 An increase in miR-141 correlated with the inhibition of DLC-1 protein in HCV-infected cells. HHID00011188 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-152(miR-152) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000462 - Downregulation Host Protein DNMT1 http://www.ncbi.nlm.nih.gov/gene/1786 Upregulation Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 Upregulationof DNMT1 as a result of miR-152 downregulation has been observed during HCC development. miR-152 may participate in HBV-induced epigenetic modifications through DNMT1. HHID00011189 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-16-1(miR-16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000070 - - Host Protein BCL2(Bcl-2) http://www.ncbi.nlm.nih.gov/gene/596 Downregulation Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 Bcl-2 has also been identified as a target of miR-16. HHID00011190 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-16-2(miR-16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000115 - - Host Protein BCL2(Bcl-2) http://www.ncbi.nlm.nih.gov/gene/596 Downregulation Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 Bcl-2 has also been identified as a target of miR-16. HHID00011191 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-193b(miR-193b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003137 HepG2 cells Upregulation Host Protein MCL1(Mcl-1) http://www.ncbi.nlm.nih.gov/gene/4170 - Predicted. 22425745 Of those, miR-193b whose expression was upregulated by 5-fold in HCV-transfected HepG2 cells was predicted to target Mcl-1, an anti-apoptotic protein affecting the response of HCC to sorafenib. HHID00011192 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-196a(miR-196) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000238 Huh-7.5 - Host Protein BACH1 http://www.ncbi.nlm.nih.gov/gene/571 Downregulation Quantitative RT-PCR, Statistical Analysis, Western Blots, Transfection and Luciferase Activity Assays. 20127796 MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins. miR-196 directly acts on the 3'-UTR of Bach1 messenger RNA and translationally represses the expression of this protein, and up-regulates HMOX1. HHID00011193 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-196a(miR-196) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000238 Huh-7.5 - Host Protein HMOX1 http://www.ncbi.nlm.nih.gov/gene/3162 Upregulation Quantitative RT-PCR, Statistical Analysis, Western Blots, Transfection and Luciferase Activity Assays. 20127796 MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins. miR-196 directly acts on the 3'-UTR of Bach1 messenger RNA and translationally represses the expression of this protein, and up-regulates HMOX1. HHID00011194 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-196a-1(miR-196) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000238 Hepatoma 9-13 cells - Host Protein BACH1 http://www.ncbi.nlm.nih.gov/gene/571 Downregulation Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 miR-196 induction downregulates Bach1 and upregulates HMOX1 in human hepatoma 9-13 cells. Therefore, miR-196 plays a protective role in HCV-HCC by directly targeting HCV genomes or indirectly regulating Bach1 and HMOX1 expression/function. HHID00011195 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-196a-1(miR-196) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000238 Hepatoma 9-13 cells - Host Protein HMOX1 http://www.ncbi.nlm.nih.gov/gene/3162 Upregulation Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 miR-196 induction downregulates Bach1 and upregulates HMOX1 in human hepatoma 9-13 cells. Therefore, miR-196 plays a protective role in HCV-HCC by directly targeting HCV genomes or indirectly regulating Bach1 and HMOX1 expression/function. HHID00011196 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-196a-2(miR-196) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000279 Hepatoma 9-13 cells - Host Protein BACH1(Bach1) http://www.ncbi.nlm.nih.gov/gene/571 Downregulation Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 miR-196 induction downregulates Bach1 and upregulates HMOX1 in human hepatoma 9-13 cells. Therefore, miR-196 plays a protective role in HCV-HCC by directly targeting HCV genomes or indirectly regulating Bach1 and HMOX1 expression/function. HHID00011197 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-196a-2(miR-196) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000279 Human hepatoma 9-13 cells - Host Protein HMOX1 http://www.ncbi.nlm.nih.gov/gene/3162 Upregulation Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 miR-196 induction downregulates Bach1 and upregulates HMOX1 in human hepatoma 9-13 cells. Therefore, miR-196 plays a protective role in HCV-HCC by directly targeting HCV genomes or indirectly regulating Bach1 and HMOX1 expression/function. HHID00011198 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-196b(miR-196) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001150 Huh-7.5 - Host Protein BACH1 http://www.ncbi.nlm.nih.gov/gene/571 Downregulation Quantitative RT-PCR, Statistical Analysis, Western Blots, Luciferase Activity Assays. 20127796 MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins. miR-196 directly acts on the 3'-UTR of Bach1 messenger RNA and translationally represses the expression of this protein, and up-regulates HMOX1. HHID00011199 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-196b(miR-196) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001150 Huh-7.5 - Host Protein HMOX1 http://www.ncbi.nlm.nih.gov/gene/3162 Upregulation Quantitative RT-PCR, Statistical Analysis, Western Blots, Luciferase Activity Assays. 20127796 MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins. miR-196 directly acts on the 3'-UTR of Bach1 messenger RNA and translationally represses the expression of this protein, and up-regulates HMOX1. HHID00011200 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-221(miR-221) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000298 - - Host Protein CDKN1B(p27/Kip1) http://www.ncbi.nlm.nih.gov/gene/1027 - Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 miR-222,a homolog of miR-221, controls CDKN1B/p27/Kip1(kinase inhibitor protein) . HHID00011201 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-222(miR-222) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000299 - - Host Protein CDKN1B(p27/Kip1) http://www.ncbi.nlm.nih.gov/gene/1027 - Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 miR-222,a homolog of miR-221, controls CDKN1B/p27/Kip1(kinase inhibitor protein) . HHID00011202 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-223(miR-223) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000300 liver Downregulation Host Protein STMN1 http://www.ncbi.nlm.nih.gov/gene/3925 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011203 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-224(miR-224) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000301 liver Upregulation Host Protein API5(API-5) http://www.ncbi.nlm.nih.gov/gene/8539 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011204 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-224(miR-224) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000301 liver Upregulation Host Protein MMP9 http://www.ncbi.nlm.nih.gov/gene/4318 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011205 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-224(miR-224) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000301 liver Upregulation Host Protein PAK4 http://www.ncbi.nlm.nih.gov/gene/10298 - - 23108868 To date, 132 miRNAs(out of 1527 identified in the human genome) have been linked to HCC(Table 1). Some of them are of clinical significance, and are valuable in diagnosing or predicting the prognosis of HCC. These miRNAs could be major factors and used for identification and classification of liver cancer. Chronic hepatitis B virus(HBV) and/or hepatitis C virus(HCV) infections resulting in hepatic fibrosis and cirrhosis are the major risk factors for HCC.Table 1 Deregulated miRNAs in HCC. HHID00011206 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-27a(miR-27a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000085 human hepatoma cells Upregulation Host Protein RXRalpha http://www.ncbi.nlm.nih.gov/gene/6256 - Luciferase assays. 23449803 Gene expression profiling of Huh-7.5 cells showed that miR-27a regulates lipid metabolism by targeting the lipid synthetic transcription factor RXRalpha and the lipid transporter ATP-binding cassette subfamily A member 1. Interestingly, the expression of miR-27a was upregulated by HCV infection and lipid overload through the adipocyte differentiation transcription factor C/EBPalpha. In turn, upregulated miR-27a repressed HCV infection and lipid storage in cells. Thus, this negative feedback mechanism might contribute to the maintenance of a low viral load and would be beneficial to the Virus by allowing it to escape host immune surveillance and establish a persistent chronic HCV infection. HHID00011207 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-29a(miR-29) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000087 LX-2 cells Upregulation Host Protein COL6A1(Collagen) http://www.ncbi.nlm.nih.gov/gene/1291 Downregulation Multiplex RT and TaqMan miRNA Assays. 21606534 Hepatitis C virus infection and hepatic stellate cell activation downregulate miR-29: miR-29 overexpression reduces hepatitis C viral abundance in culture. miR-29 overexpression in LX-2 cells decreased collagen expression and modestly decreased proliferation. HHID00011208 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-29b(miR-29) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000105 LX-2 cells Upregulation Host Protein COL6A1(Collagen) http://www.ncbi.nlm.nih.gov/gene/1291 Downregulation Multiplex RT and TaqMan miRNA Assays. 21606534 Hepatitis C virus infection and hepatic stellate cell activation downregulate miR-29: miR-29 overexpression reduces hepatitis C viral abundance in culture. miR-29 overexpression in LX-2 cells decreased collagen expression and modestly decreased proliferation. HHID00011209 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-29c(miR-29) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000735 LX-2 cells Upregulation Host Protein COL6A1(Collagen) http://www.ncbi.nlm.nih.gov/gene/1291 Downregulation Multiplex RT and TaqMan miRNA Assays. 21606534 Hepatitis C virus infection and hepatic stellate cell activation downregulate miR-29: miR-29 overexpression reduces hepatitis C viral abundance in culture. miR-29 overexpression in LX-2 cells decreased collagen expression and modestly decreased proliferation. HHID00011210 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-301(miR-301) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000745 Huh7.5 cells Downregulation Host mRNA C-Met http://www.ncbi.nlm.nih.gov/gene/4233 Downregulation Predicted. 23418453 Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-alpha treatment.Our data suggests that, in addition to possible antitumor effects, treatment of HCV-infected Huh7.5 cells with IFN-α upregulates miR-130a/301 thereby reducing c-Met expression and HCV pathogenesis. HHID00011211 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-320c(miR-320c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003778 Serum Upregulation Host Protein ADAMTS5 http://www.ncbi.nlm.nih.gov/gene/11096 - miRecords, microarray hybridization, microRNA array. 23549102 Serum miR-134, miR-320c and miR-483-5p were significantly upregulated during HCV infection. miR-320c and miR-483-5p were also upregulated in HCV- JFH1 infected cells and cell culture supernatant. ADAMTS5,a regulator of cell invasion is also a known target of miR-320c. HHID00011212 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-345(miR-345) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000825 Hepatoma cells Upregulation Host Protein P21 http://www.ncbi.nlm.nih.gov/gene/644914 Downregulation TaqMan low density array, qPCR. 23577194 HCV core protein enhances the expression of microRNA-345 which then down-regulates p21(Waf1/Cip1) expression. It is the first time that HCV core protein has ever been shown to suppress p21(Waf1/Cip1) gene expression through miR-345 targeting.HCV core-induced microRNA-345 suppressed p21(Waf1/Cip1) gene expression through targeting its 3' untranslated region in human hepatoma cells. HHID00011213 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-34a(miR-34a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000268 HepG2 cells - Host Protein CCND1(cyclin D1) http://www.ncbi.nlm.nih.gov/gene/595 - Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 miR-34a also regulates G1/S transition molecules including cyclin D1, CDK4 and CDK2 in HCC. HHID00011214 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-34a(miR-34a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000268 HepG2 cells - Host Protein CDK2 http://www.ncbi.nlm.nih.gov/gene/1017 - Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 miR-34a also regulates G1/S transition molecules including cyclin D1, CDK4 and CDK2 in HCC. HHID00011215 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-34a(miR-34a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000268 HepG2 cells - Host Protein CDK4 http://www.ncbi.nlm.nih.gov/gene/1019 - Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 miR-34a also regulates G1/S transition molecules including cyclin D1, CDK4 and CDK2 in HCC. HHID00011216 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-449a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001648 - - Host Protein NOTCH http://www.ncbi.nlm.nih.gov/gene/4851 - Luciferase Assay, Western Blot and Immunofluorescence Microscopy. 23226395 Takentogether it is demonstrated that miRNA-449a plays an important role in modulating expression of YKL40 through targeting the components of the NOTCH signaling pathway following HCV infection. HHID00011217 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-449a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001648 - - Host Protein YKL40 http://www.ncbi.nlm.nih.gov/gene/1116 - Luciferase Assay, Western Blot and Immunofluorescence Microscopy. 23226395 Takentogether it is demonstrated that miRNA-449a plays an important role in modulating expression of YKL40 through targeting the components of the NOTCH signaling pathway following HCV infection. HHID00011218 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-483-5p(miR-483-5p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002467 Serum Upregulation Host Protein ERK1 http://www.ncbi.nlm.nih.gov/gene/5595 - miRecords, microarray hybridization, microRNA array. 23549102 Serum miR-134, miR-320c and miR-483-5p were significantly upregulated during HCV infection. miR-320c and miR-483-5p were also upregulated in HCV- JFH1 infected cells and cell culture supernatant. In case of miR-483-5p, validated targets included SRF a modulator of VEGF signaling and ERK1 a member of the Ras-ERK intracellular signaling pathway that is modulated by HCV proteins such as NS5A. HHID00011219 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-483-5p(miR-483-5p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002467 Serum Upregulation Host Protein SRF http://www.ncbi.nlm.nih.gov/gene/6722 - miRecords, microarray hybridization, microRNA array. 23549102 Serum miR-134, miR-320c and miR-483-5p were significantly upregulated during HCV infection. miR-320c and miR-483-5p were also upregulated in HCV- JFH1 infected cells and cell culture supernatant. In case of miR-483-5p, validated targets included SRF a modulator of VEGF signaling and ERK1 a member of the Ras-ERK intracellular signaling pathway that is modulated by HCV proteins such as NS5A. HHID00011220 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-491(miR-491) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003126 Huh7 - Host Protein PIK3CA(PI3 kinase) http://www.ncbi.nlm.nih.gov/gene/5290 Downregulation miRNA transfection, immunoblot analysis, miRNA array analysis, dual luciferase assay, cell proliferation assay, RT-PCR. 21802413 Under inhibition of PI3 kinase by LY294002, the suppressive effect of miR-491 on HCV replication was abolished, indicating that suppression of HCV replication by miR-491 was dependent on the PI3 kinase/Akt pathway. HHID00011221 Hepatitis C virus(HCV) Mus musculus Host miRNA mmu-mir-101a(miR-101) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000148 tissue samples (104 HCC, 90 adjacent cirrhotic livers, 21 normal livers) as well as in 35 HCC cell lines - Host Protein Mcl1(Mcl-1) http://www.ncbi.nlm.nih.gov/gene/17210 - Microarray and Computational Analysis,Quantitative PCR and Western Blot Analysis,premiRs and antagomiRs Transfection,Analysis of Putative miR-221 Targets. 23108868 Two proapoptotic members, Bmf and Bim, are targeted by miR-221 and miR-15, respectively. Three antiapoptotic members, Bcl-2, Mcl-1 and Bcl-w are targets of miR-29, miR-101 and miR-122, respectively. HHID00011222 Hepatitis C virus(HCV) Mus musculus Host miRNA mmu-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000256 tissue samples (104 HCC, 90 adjacent cirrhotic livers, 21 normal livers) as well as in 35 HCC cell lines - Host Protein Bcl2l2(Bcl-w) http://www.ncbi.nlm.nih.gov/gene/12050 - Microarray and Computational Analysis,Quantitative PCR and Western Blot Analysis,premiRs and antagomiRs Transfection,Analysis of Putative miR-221 Targets. 23108868 Two proapoptotic members, Bmf and Bim, are targeted by miR-221 and miR-15, respectively. Three antiapoptotic members, Bcl-2, Mcl-1 and Bcl-w are targets of miR-29, miR-101 and miR-122, respectively. HHID00011223 Hepatitis C virus(HCV) Mus musculus Host miRNA mmu-mir-15(miR-15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000564 - - Host Protein Bcl2l11(Bim) http://www.ncbi.nlm.nih.gov/gene/12125 - Microarray and Computational Analysis,Quantitative PCR and Western Blot Analysis,premiRs and antagomiRs Transfection,Analysis of Putative miR-221 Targets. 23108868 Two proapoptotic members, Bmf and Bim, are targeted by miR-221 and miR-15, respectively. Three antiapoptotic members, Bcl-2, Mcl-1 and Bcl-w are targets of miR-29, miR-101 and miR-122, respectively. HHID00011224 Hepatitis C virus(HCV) Mus musculus Host miRNA mmu-mir-221(miR-221) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000709 - - Host Protein Bmf http://www.ncbi.nlm.nih.gov/gene/171543 - Microarray and Computational Analysis,Quantitative PCR and Western Blot Analysis,premiRs and antagomiRs Transfection,Analysis of Putative miR-221 Targets. 23108868 Two proapoptotic members, Bmf and Bim, are targeted by miR-221 and miR-15, respectively. Three antiapoptotic members, Bcl-2, Mcl-1 and Bcl-w are targets of miR-29, miR-101 and miR-122, respectively. HHID00011225 Hepatitis C virus(HCV) Mus musculus Host miRNA mmu-mir-29a(miR-29a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000576 tissue samples (104 HCC, 90 adjacent cirrhotic livers, 21 normal livers) as well as in 35 HCC cell lines - Host Protein Bcl2(Bcl-2) http://www.ncbi.nlm.nih.gov/gene/12043 - Microarray and Computational Analysis,Quantitative PCR and Western Blot Analysis,premiRs and antagomiRs Transfection,Analysis of Putative miR-221 Targets. 23108868 Two proapoptotic members, Bmf and Bim, are targeted by miR-221 and miR-15, respectively. Three antiapoptotic members, Bcl-2, Mcl-1 and Bcl-w are targets of miR-29, miR-101 and miR-122, respectively. HHID00011226 Hepatitis C virus(HCV) Rattus norvegicus Host miRNA rno-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000891 cultured rat cells - Host Protein Slc7a1(CAT-1) http://www.ncbi.nlm.nih.gov/gene/25648 Downregulation Mutational analyses. 17381319 CAT-1 activity is absent in the quiescent liver, but it is increased in primary or transformed hepatocytes.Incontrast, interaction of miR-122 with the 3'-noncoding region(3'NCR) of the cellularmRNA encoding the cationic amino acid transporter CAT-1 resulted in the down-regulation of CAT-1 protein abundance. HHID00011227 Hepatitis E virus(HEV) Sus scrofa Host miRNA ssc-mir-221(miR-221) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008221 HEK 293 cells - Host Protein CDKN1B(P27kip1) http://www.ncbi.nlm.nih.gov/gene/397584 - QRT-PCR, Luciferase reporter assay, Western blot. 23579640 Identification of miR-221 and -222 as important regulators in genotype IV swine hepatitis E virus ORF3-expressing HEK 293 cells. We found a significant down-regulation of miR-221 and -222 in ORF3 expressing human embryonic kidney 293 cell line. Among the 116 candidate targets genes of miR-221 and -222 that we detected in silico, we demonstrated that the expression of the cyclin-dependent kinase inhibitor 1B, also named p27(kip1), was directly regulated by these miRNAs. HHID00011228 Hepatitis E virus(HEV) Sus scrofa Host miRNA ssc-mir-222(miR-222) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013151 HEK 293 cells - Host Protein CDKN1B(P27kip1) http://www.ncbi.nlm.nih.gov/gene/397584 - QRT-PCR, Luciferase reporter assay, Western blot. 23579640 Identification of miR-221 and -222 as important regulators in genotype IV swine hepatitis E virus ORF3-expressing HEK 293 cells. We found a significant down-regulation of miR-221 and -222 in ORF3 expressing human embryonic kidney 293 cell line. Among the 116 candidate targets genes of miR-221 and -222 that we detected in silico, we demonstrated that the expression of the cyclin-dependent kinase inhibitor 1B, also named p27(kip1), was directly regulated by these miRNAs. HHID00011229 Herpes simplex virus 1(HSV-1) Homo sapiens Host LncRNA NEAT1 http://lncrnadb.com/Detail.aspx?TKeyID=105 - - Host Protein CXCL8(IL8) http://www.ncbi.nlm.nih.gov/gene/3576 Upregulation - 24507715 Here we show that nuclear enriched abundant transcript 1 (NEAT1), an essential LncRNA for the formation of nuclear body paraspeckles, is induced by influenza virus and herpes simplex virus infection as well as by Toll-like receptor3-p38 pathway-triggered poly I:C stimulation, resulting in excess formation of paraspeckles.We found that NEAT1 facilitates the expression of antiviral genes including cytokines such as interleukin-8 (IL8). HHID00011230 Herpes simplex virus 1(HSV-1) Homo sapiens Host LncRNA NEAT1 http://lncrnadb.com/Detail.aspx?TKeyID=105 - - Host Protein SFPQ http://www.ncbi.nlm.nih.gov/gene/6421 - - 24507715 Here we show that nuclear enriched abundant transcript 1 (NEAT1), an essential LncRNA for the formation of nuclear body paraspeckles, is induced by influenza virus and herpes simplex virus infection as well as by Toll-like receptor3-p38 pathway-triggered poly I:C stimulation, resulting in excess formation of paraspeckles.We found that splicing factor proline/glutamine-rich (SFPQ), a NEAT1-binding paraspeckle protein, is a repressor of IL8 transcription, and that NEAT1 induction relocates SFPQ from the IL8 promoter to the paraspeckles, leading to transcriptional activation of IL8. HHID00011231 Human T-cell leukemia virus 1(HTLV-1) Homo sapiens Host miRNA hsa-mir-130b(miR-130b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000748 human T-cell lines Upregulation Host Protein TP53INP1 http://www.ncbi.nlm.nih.gov/gene/94241 - Reporter assays, TUNEL assay, RAKE analysis, Cell proliferation assay, Quantitative real-time PCR, microarray. 18974142 Here, we profiled miRNA expression in HTLV-1-transformed human T-cell lines and primary peripheral blood mononuclear cells from adult T-cell leukemia patients. Analyses of 11 different profiles revealed six miRNAs that were consistently up-regulated. Two of the up-regulated miRNAs (miR-93 and miR-130b) target the 3' untranslated region (3'UTR) of the mRNA for a tumor suppressor protein, tumor protein 53-induced nuclear protein 1 (TP53INP1). . HHID00011232 Human T-cell leukemia virus 1(HTLV-1) Homo sapiens Host miRNA hsa-mir-31 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000089 - Downregulation Host Protein MAP3K14(NIK) http://www.ncbi.nlm.nih.gov/gene/9020 Upregulation RT-PCR. 23189820 Some studies have demonstrated that some deregulations of miRNA are involved in the pathogenesis of HTLV-1. Furthermore, global analyses of ATL patient samples have provided a conceptual progress that Polycomb family induces miR-31 silencing, resulting in overexpression of NF-kappaB inducing kinase(NIK) following NF-kappaB activation. HHID00011233 Human T-cell leukemia virus 1(HTLV-1) Homo sapiens Host miRNA hsa-mir-93(miR-93) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000095 human T-cell lines Upregulation Host Protein TP53INP1 http://www.ncbi.nlm.nih.gov/gene/94241 - Reporter assays, TUNEL assay, RAKE analysis, Cell proliferation assay, Quantitative real-time PCR, microarray. 18974142 Here, we profiled miRNA expression in HTLV-1-transformed human T-cell lines and primary peripheral blood mononuclear cells from adult T-cell leukemia patients. Analyses of 11 different profiles revealed six miRNAs that were consistently up-regulated. Two of the up-regulated miRNAs (miR-93 and miR-130b) target the 3' untranslated region (3'UTR) of the mRNA for a tumor suppressor protein, tumor protein 53-induced nuclear protein 1 (TP53INP1). . HHID00011234 Human cytomegalovirus(HCMV) Homo sapiens Host miRNA hsa-mir-100(miR-100) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000102 MRC-5, HeLa, and 293T cells. - Host Protein MTOR(mTOR) http://www.ncbi.nlm.nih.gov/gene/2475 Downregulation QRT-PCR, HCMV growth in the presence of miR-100 and miR-101 mimics, miRNA target verification, miRNA microarray, Statistical analysis, miRNA data analysis, Immunoblot analyses. 18596100 Human cytomegalovirus infection alters the expression of cellular microRNA species that affect its replication.miRNAs miR-100 and miR-101 were chosen for further analyses based on their reproducible changes in expression after infection and on the basis of having predicted targets in the 3' untranslated regions (3'-UTR) of genes encoding components of the mammalian target of rapamycin (mTOR) pathway, which is important during HCMV infection. Together,miR-100 and miR-101 reduced mTOR protein levels. HHID00011235 Human cytomegalovirus(HCMV) Homo sapiens Host miRNA hsa-mir-101(miR-101) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000103 MRC-5, HeLa, and 293T cells. - Host Protein MTOR(mTOR) http://www.ncbi.nlm.nih.gov/gene/2475 Downregulation QRT-PCR, HCMV growth in the presence of miR-100 and miR-101 mimics, miRNA target verification, miRNA microarray, Statistical analysis, miRNA data analysis, Immunoblot analyses. 18596100 Human cytomegalovirus infection alters the expression of cellular microRNA species that affect its replication.miRNAs miR-100 and miR-101 were chosen for further analyses based on their reproducible changes in expression after infection and on the basis of having predicted targets in the 3' untranslated regions (3'-UTR) of genes encoding components of the mammalian target of rapamycin (mTOR) pathway, which is important during HCMV infection. Together,miR-100 and miR-101 reduced mTOR protein levels. HHID00011236 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host LncRNA 7SL # - - Host Protein APOBEC3F(A3F) http://www.ncbi.nlm.nih.gov/gene/200316 - - 18067920 In this study, we demonstrate that A3F specifically interacts with cellular signal recognition particle(SRP) RNA(7SL RNA), which is selectively packaged into HIV-1 virions. HHID00011237 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host LncRNA 7SL # - - Host Protein APOBEC3G(A3G) http://www.ncbi.nlm.nih.gov/gene/60489 - RNase protection assay.Immunoblot analysis, Quantitative real-time PCR (qRT-PCR), Immunoprecipitation. 17881443 We demonstrate here that A3G selectively interacts with certain polymerase III(Pol III)-derived RNAs, including Y3 and 7SL RNAs. Among A3G-binding Pol III-derived RNAs, 7SL RNA was preferentially packaged into human immunodeficiency virus type 1(HIV-1) particles. HHID00011238 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host LncRNA 7SL # 293T cells Downregulation Host Protein APOBEC3G(A3G) http://www.ncbi.nlm.nih.gov/gene/60489 Downregulation Cell culture, transfections, viral infectivity(MAGI) assays and antibodies Immunoprecipitation and immunoblot analysis qRT-PCR. 22859935 Like A3G, A3H HapII also demonstrated high binding affinity to host small RNAs such as 7SL and Y RNAs. Mutation of a critical amino acid, W115A resulted in reduced expression level, decreased affinity for 7SL RNA, impairment of virion packaging and reduced anti-viral activity. . HHID00011239 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host LncRNA 7SL # 293T cells Downregulation Host Protein APOBEC3H(A3H) http://www.ncbi.nlm.nih.gov/gene/164668 Downregulation Cell culture, transfections, viral infectivity(MAGI) assays and antibodies Immunoprecipitation and immunoblot analysis qRT-PCR. 22859935 Like A3G, A3H HapII also demonstrated high binding affinity to host small RNAs such as 7SL and Y RNAs. Mutation of a critical amino acid, W115A resulted in reduced expression level, decreased affinity for 7SL RNA, impairment of virion packaging and reduced anti-viral activity. HHID00011240 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host LncRNA NEAT1 http://lncrnadb.com/Detail.aspx?TKeyID=105 - Upregulation Host Protein PSF http://www.ncbi.nlm.nih.gov/gene/6421 Upregulation LncRNA profiling, Western blotting, qRT-PCR, Immunofluorescence and confocal microscopy. 23362321 Because several cellular proteins that play roles in HIV-1 replication are found in paraspeckles(e.g., PSF, p54nrb, and matrin 3 [The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control43?The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control45]), we were moved to investigate NEAT1 interaction with HIV-1.we therefore checked to see how our knockdown of NEAT1 affected the number of paraspeckles in cells. PSF and PSP1 are known protein components of paraspeckles These results, consistent with findings from others(42), support that NEAT1 lncRNA composes an important scaffolding function for paraspeckles. HHID00011241 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host LncRNA NEAT1 http://lncrnadb.com/Detail.aspx?TKeyID=105 - Upregulation Host Protein PSPC1(PSP1) http://www.ncbi.nlm.nih.gov/gene/55269 Upregulation LncRNA profiling, Western blotting, qRT-PCR, Immunofluorescence and confocal microscopy. 23362321 Because several cellular proteins that play roles in HIV-1 replication are found in paraspeckles(e.g., PSF, p54nrb, and matrin 3 [The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control43?The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control45]), we were moved to investigate NEAT1 interaction with HIV-1.we therefore checked to see how our knockdown of NEAT1 affected the number of paraspeckles in cells. PSF and PSP1 are known protein components of paraspeckles These results, consistent with findings from others(42), support that NEAT1 lncRNA composes an important scaffolding function for paraspeckles. HHID00011242 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host LncRNA Y # 293T cells Downregulation Host Protein APOBEC3G(A3G) http://www.ncbi.nlm.nih.gov/gene/60489 Downregulation Cell culture, transfections, viral infectivity(MAGI) assays and antibodies Immunoprecipitation and immunoblot analysis qRT-PCR. 22859935 Like A3G, A3H HapII also demonstrated high binding affinity to host small RNAs such as 7SL and Y RNAs. Mutation of a critical amino acid, W115A resulted in reduced expression level, decreased affinity for 7SL RNA, impairment of virion packaging and reduced anti-viral activity. . HHID00011243 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host LncRNA Y # 293T cells Downregulation Host Protein APOBEC3H(A3H) http://www.ncbi.nlm.nih.gov/gene/164668 Downregulation Cell culture, transfections, viral infectivity(MAGI) assays and antibodies Immunoprecipitation and immunoblot analysis qRT-PCR. 22859935 Like A3G, A3H HapII also demonstrated high binding affinity to host small RNAs such as 7SL and Y RNAs. Mutation of a critical amino acid, W115A resulted in reduced expression level, decreased affinity for 7SL RNA, impairment of virion packaging and reduced anti-viral activity. HHID00011244 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host LncRNA Y http://www.lncrnadb.org/Detail.aspx?TKeyID=123 293T cells Downregulation Host Protein APOBEC3G http://www.ncbi.nlm.nih.gov/gene/60489 Downregulation Cell culture, transfections, viral infectivity(MAGI) assays and antibodies Immunoprecipitation and immunoblot analysis qRT-PCR. 22859935 Unique motif RLYY(F/Y)W of APOBEC3G (A3G) and APOBEC3F (A3F) required for 7SL RNA binding and HIV-1 incorporation is also conserved in all A3H variants. Like A3G, A3H HapII also demonstrated high binding affinity to host small RNAs such as 7SL and Y RNAs. Mutation of a critical amino acid, W115A resulted in reduced expression level, decreased affinity for 7SL RNA, impairment of virion packaging and reduced anti-viral activity. HHID00011245 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host LncRNA Y http://www.lncrnadb.org/Detail.aspx?TKeyID=123 293T cells Downregulation Host Protein APOBEC3H http://www.ncbi.nlm.nih.gov/gene/164668 Downregulation Cell culture, viral infectivity(MAGI) assays and antibodies Immunoprecipitation and immunoblot analysisqRT-PCR, transfections. 22859935 Unique motif RLYY(F/Y)W of APOBEC3G (A3G) and APOBEC3F (A3F) required for 7SL RNA binding and HIV-1 incorporation is also conserved in all A3H variants. Like A3G, A3H HapII also demonstrated high binding affinity to host small RNAs such as 7SL and Y RNAs. Mutation of a critical amino acid, W115A resulted in reduced expression level, decreased affinity for 7SL RNA, impairment of virion packaging and reduced anti-viral activity. HHID00011246 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA has-miR-17-3p(has-miR-17-3p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000071 - - Host mRNA EP300 http://www.ncbi.nlm.nih.gov/gene/2033 Upregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011247 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA has-miR-17-5p(has-miR-17*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000071 - - Host mRNA EP300 http://www.ncbi.nlm.nih.gov/gene/2033 Upregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011248 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA has-miR-198(has-miR-198) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000240 - - Host mRNA CCNT1 http://www.ncbi.nlm.nih.gov/gene/904 Upregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011249 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA has-miR-20a(has-miR-20a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000076 - - Host mRNA CDC42 http://www.ncbi.nlm.nih.gov/gene/998 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011250 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA has-miR-20a(has-miR-20a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000076 - - Host mRNA DNMT3A http://www.ncbi.nlm.nih.gov/gene/1788 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011251 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA has-miR-20a(has-miR-20a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000076 - - Host mRNA DNMT3B http://www.ncbi.nlm.nih.gov/gene/1789 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011252 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA has-miR-20a(has-miR-20a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000076 - - Host mRNA KAT8 http://www.ncbi.nlm.nih.gov/gene/84148 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011253 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA has-miR-20a(has-miR-20a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000076 - - Host mRNA MCL1 http://www.ncbi.nlm.nih.gov/gene/4170 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011254 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA has-miR-20a(has-miR-20a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000076 - - Host mRNA TCL1A http://www.ncbi.nlm.nih.gov/gene/8115 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011255 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA has-miR-27a(has-miR-27a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000085 - - Host mRNA CCNT1 http://www.ncbi.nlm.nih.gov/gene/904 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011256 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA has-miR-27a-5P(has-miR-27a*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000085 - - Host mRNA CCNT1 http://www.ncbi.nlm.nih.gov/gene/904 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011257 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA has-miR-28-3p(has-miR-28-3p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000086 - - Host mRNA APOBEC3F http://www.ncbi.nlm.nih.gov/gene/200316 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011258 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA has-miR-28-3p(has-miR-28-3p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000086 - - Host mRNA APOBEC3G http://www.ncbi.nlm.nih.gov/gene/60489 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011259 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA has-miR-28-3p(has-miR-28-3p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000086 - - Host mRNA CCR5 http://www.ncbi.nlm.nih.gov/gene/1234 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011260 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA has-miR-28-3p(has-miR-28-3p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000086 - - Host mRNA CD4 http://www.ncbi.nlm.nih.gov/gene/920 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011261 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA has-miR-28-5p(has-miR-28-5p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000086 - - Host mRNA APOBEC3F http://www.ncbi.nlm.nih.gov/gene/200316 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011262 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA has-miR-28-5p(has-miR-28-5p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000086 - - Host mRNA APOBEC3G http://www.ncbi.nlm.nih.gov/gene/60489 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011263 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA has-miR-28-5p(has-miR-28-5p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000086 - - Host mRNA CCR5 http://www.ncbi.nlm.nih.gov/gene/1234 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011264 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA has-miR-28-5p(has-miR-28-5p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000086 - - Host mRNA CD4 http://www.ncbi.nlm.nih.gov/gene/920 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011265 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA has-mir-20a(miR-20a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000076 - - Host Protein KAT2B(PCAF) http://www.ncbi.nlm.nih.gov/gene/8850 - Reporter assay, RNAhybrid. 23043098 Independently,miR-17-5p and miR-20a were found by a separate group to target p300/CBPassociated factor(PCAF), another cellular cofactor of the viral Tat protein. HHID00011266 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7a(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000060 - - Host mRNA DICER http://www.ncbi.nlm.nih.gov/gene/23405 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011267 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7a(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000060 - - Host mRNA IL-10 http://www.ncbi.nlm.nih.gov/gene/3586 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011268 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7a(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000060 - - Host mRNA LIN28 http://www.ncbi.nlm.nih.gov/gene/79727 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011269 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7a(let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000060 HUT78 cells - Host mRNA IL10(IL-10) http://www.ncbi.nlm.nih.gov/gene/3586 Upregulation Predicted. 22586040 Our initial in vitro studies demonstrated that HIV-1-infected HUT78 cells expressed significantly higher IL-10 levels compared with uninfected cultures. IL-10 plays an important role in the dysregulated cytotoxic T cell response to HIV-1, and in silico algorithms suggested that let-7 miRNAs target IL10 mRNA. HHID00011270 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7b(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000063 - - Host mRNA DICER http://www.ncbi.nlm.nih.gov/gene/23405 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011271 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7b(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000063 - - Host mRNA IL-10 http://www.ncbi.nlm.nih.gov/gene/3586 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011272 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7b(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000063 - - Host mRNA LIN28 http://www.ncbi.nlm.nih.gov/gene/79727 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011273 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7b(let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000063 HUT78 cells - Host mRNA IL10(IL-10) http://www.ncbi.nlm.nih.gov/gene/3586 Upregulation Predicted. 22586040 Our initial in vitro studies demonstrated that HIV-1-infected HUT78 cells expressed significantly higher IL-10 levels compared with uninfected cultures. IL-10 plays an important role in the dysregulated cytotoxic T cell response to HIV-1, and in silico algorithms suggested that let-7 miRNAs target IL10 mRNA. HHID00011274 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7c(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000064 - - Host mRNA DICER http://www.ncbi.nlm.nih.gov/gene/23405 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011275 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7c(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000064 - - Host mRNA IL-10 http://www.ncbi.nlm.nih.gov/gene/3586 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011276 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7c(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000064 - - Host mRNA LIN28 http://www.ncbi.nlm.nih.gov/gene/79727 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011277 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7c(let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000064 HUT78 cells - Host mRNA IL10(IL-10) http://www.ncbi.nlm.nih.gov/gene/3586 Upregulation Predicted. 22586040 Our initial in vitro studies demonstrated that HIV-1-infected HUT78 cells expressed significantly higher IL-10 levels compared with uninfected cultures. IL-10 plays an important role in the dysregulated cytotoxic T cell response to HIV-1, and in silico algorithms suggested that let-7 miRNAs target IL10 mRNA. HHID00011278 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7d(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000065 - - Host mRNA DICER http://www.ncbi.nlm.nih.gov/gene/23405 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011279 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7d(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000065 - - Host mRNA IL-10 http://www.ncbi.nlm.nih.gov/gene/3586 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011280 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7d(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000065 - - Host mRNA LIN28 http://www.ncbi.nlm.nih.gov/gene/79727 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011281 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7d(let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000065 HUT78 cells - Host mRNA IL10(IL-10) http://www.ncbi.nlm.nih.gov/gene/3586 Upregulation Predicted. 22586040 Our initial in vitro studies demonstrated that HIV-1-infected HUT78 cells expressed significantly higher IL-10 levels compared with uninfected cultures. IL-10 plays an important role in the dysregulated cytotoxic T cell response to HIV-1, and in silico algorithms suggested that let-7 miRNAs target IL10 mRNA. HHID00011282 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7e(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000066 - - Host mRNA DICER http://www.ncbi.nlm.nih.gov/gene/23405 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011283 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7e(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000066 - - Host mRNA IL-10 http://www.ncbi.nlm.nih.gov/gene/3586 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011284 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7e(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000066 - - Host mRNA LIN28 http://www.ncbi.nlm.nih.gov/gene/79727 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011285 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7e(let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000066 HUT78 cells - Host mRNA IL10(IL-10) http://www.ncbi.nlm.nih.gov/gene/3586 Upregulation Predicted. 22586040 Our initial in vitro studies demonstrated that HIV-1-infected HUT78 cells expressed significantly higher IL-10 levels compared with uninfected cultures. IL-10 plays an important role in the dysregulated cytotoxic T cell response to HIV-1, and in silico algorithms suggested that let-7 miRNAs target IL10 mRNA. HHID00011286 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7f(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000067 - - Host mRNA DICER http://www.ncbi.nlm.nih.gov/gene/23405 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011287 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7f(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000067 - - Host mRNA IL-10 http://www.ncbi.nlm.nih.gov/gene/3586 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011288 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7f(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000067 - - Host mRNA LIN28 http://www.ncbi.nlm.nih.gov/gene/79727 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011289 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7f(let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000067 HUT78 cells - Host mRNA IL10(IL-10) http://www.ncbi.nlm.nih.gov/gene/3586 Upregulation Predicted. 22586040 Our initial in vitro studies demonstrated that HIV-1-infected HUT78 cells expressed significantly higher IL-10 levels compared with uninfected cultures. IL-10 plays an important role in the dysregulated cytotoxic T cell response to HIV-1, and in silico algorithms suggested that let-7 miRNAs target IL10 mRNA. HHID00011290 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7g(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000433 - - Host mRNA DICER http://www.ncbi.nlm.nih.gov/gene/23405 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011291 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7g(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000433 - - Host mRNA IL-10 http://www.ncbi.nlm.nih.gov/gene/3586 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011292 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7g(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000433 - - Host mRNA LIN28 http://www.ncbi.nlm.nih.gov/gene/79727 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011293 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7g(let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000433 HUT78 cells - Host mRNA IL10(IL-10) http://www.ncbi.nlm.nih.gov/gene/3586 Upregulation Predicted. 22586040 Our initial in vitro studies demonstrated that HIV-1-infected HUT78 cells expressed significantly higher IL-10 levels compared with uninfected cultures. IL-10 plays an important role in the dysregulated cytotoxic T cell response to HIV-1, and in silico algorithms suggested that let-7 miRNAs target IL10 mRNA. HHID00011294 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7g-3p(hsa-let-7g*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000433 - - Host mRNA DICER http://www.ncbi.nlm.nih.gov/gene/23405 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011295 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7g-3p(hsa-let-7g*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000433 - - Host mRNA IL-10 http://www.ncbi.nlm.nih.gov/gene/3586 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011296 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7g-3p(hsa-let-7g*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000433 - - Host mRNA LIN28 http://www.ncbi.nlm.nih.gov/gene/79727 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011297 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7i(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000434 - - Host mRNA DICER http://www.ncbi.nlm.nih.gov/gene/23405 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011298 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7i(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000434 - - Host mRNA IL-10 http://www.ncbi.nlm.nih.gov/gene/3586 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011299 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7i(has-let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000434 - - Host mRNA LIN28 http://www.ncbi.nlm.nih.gov/gene/79727 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011300 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-let-7i(let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000434 HUT78 cells - Host mRNA IL10(IL-10) http://www.ncbi.nlm.nih.gov/gene/3586 Upregulation Predicted. 22586040 Our initial in vitro studies demonstrated that HIV-1-infected HUT78 cells expressed significantly higher IL-10 levels compared with uninfected cultures. IL-10 plays an important role in the dysregulated cytotoxic T cell response to HIV-1, and in silico algorithms suggested that let-7 miRNAs target IL10 mRNA. HHID00011301 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-128(hsa-miR-128) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000447 - - Host mRNA SNAP25 http://www.ncbi.nlm.nih.gov/gene/6616 - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011302 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-146a(hsa-miR-146) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 - - Host mRNA CCL8 http://www.ncbi.nlm.nih.gov/gene/6355 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011303 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-146b(hsa-miR-146) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003129 - - Host mRNA CCL8 http://www.ncbi.nlm.nih.gov/gene/6355 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011304 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-150(hsa-miR-150) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000479 - - Host mRNA APOBEC3F http://www.ncbi.nlm.nih.gov/gene/200316 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011305 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-150(hsa-miR-150) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000479 - - Host mRNA APOBEC3G http://www.ncbi.nlm.nih.gov/gene/60489 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011306 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-150(hsa-miR-150) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000479 - - Host mRNA CCNT1 http://www.ncbi.nlm.nih.gov/gene/904 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011307 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-150(hsa-miR-150) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000479 - - Host mRNA CCR5 http://www.ncbi.nlm.nih.gov/gene/1234 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011308 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-150(hsa-miR-150) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000479 - - Host mRNA CD4 http://www.ncbi.nlm.nih.gov/gene/920 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011309 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-150-3p(hsa-miR-150*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000479 - - Host mRNA APOBEC3F http://www.ncbi.nlm.nih.gov/gene/200316 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011310 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-150-3p(hsa-miR-150*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000479 - - Host mRNA APOBEC3G http://www.ncbi.nlm.nih.gov/gene/60489 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011311 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-150-3p(hsa-miR-150*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000479 - - Host mRNA CCNT1 http://www.ncbi.nlm.nih.gov/gene/904 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011312 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-150-3p(hsa-miR-150*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000479 - - Host mRNA CCR5 http://www.ncbi.nlm.nih.gov/gene/1234 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011313 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-150-3p(hsa-miR-150*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000479 - - Host mRNA CD4 http://www.ncbi.nlm.nih.gov/gene/920 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011314 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-17(hsa-miR-17) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000071 - - Host mRNA KAT8 http://www.ncbi.nlm.nih.gov/gene/84148 - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011315 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 lymphocyte Downregulation Host mRNA KAT2B(PCAF) http://www.ncbi.nlm.nih.gov/gene/8850 - Infection and flow cytometry, Transfection Microarray probes, hybridization and analysis, Reverse transcription and real-time PCR. 21569500 Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1. Two members of the hsa-miR-17/92 cluster, hsa-miR-17-5p and hsa-miR-20a, target the mRNA of the PCAF cofactor of Tat trans-activation. Our results and published microarrays agree in downregulation of these miRNA by HIV-1. HHID00011316 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-17-5p(hsa-miR-17-5p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000071 - - Host mRNA KAT8 http://www.ncbi.nlm.nih.gov/gene/84148 - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011317 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-17-5p(miR-17-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 - - Host Protein KAT2B(PCAF) http://www.ncbi.nlm.nih.gov/gene/8850 - Reporter assay, RNAhybrid. 23043098 Independently,miR-17-5p and miR-20a were found by a separate group to target p300/CBPassociated factor(PCAF), another cellular cofactor of the viral Tat protein. HHID00011318 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-223-5p(hsa-miR-223*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004570 - - Host Protein APOBEC3F http://www.ncbi.nlm.nih.gov/gene/200316 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011319 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-223-5p(hsa-miR-223*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004570 - - Host Protein APOBEC3G http://www.ncbi.nlm.nih.gov/gene/60489 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011320 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-223-5p(hsa-miR-223*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004570 - - Host Protein CCNT1 http://www.ncbi.nlm.nih.gov/gene/904 - - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011321 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-223-5p(hsa-miR-223*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004570 - - Host Protein LIF http://www.ncbi.nlm.nih.gov/gene/3976 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011322 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-223-5p(hsa-miR-223*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004570 - - Host Protein RhoB http://www.ncbi.nlm.nih.gov/gene/388 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011323 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-223-5p(hsa-miR-223*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004570 - - Host Protein SP3 http://www.ncbi.nlm.nih.gov/gene/6670 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011324 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-27b(miR-27b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000440 CD4+ T lymphocytes - Host Protein CCNT1(cyclin T1) http://www.ncbi.nlm.nih.gov/gene/904 Downregulation CD4+ T cell isolation, miRNA transfections, HIV-1 assays, Protein and RNA analyses, Ago2 immunoprecipitation, Luciferase assays, miRNA expression profiling. 22205749 An miR-27b binding site within the cyclin T1 3' untranslated region (3'UTR) was identified and confirmed to be functional after the mutation of key resides abrogated the ability of miR-27b to decrease the expression of a luciferase reporter upstream of the cyclin T1 3'UTR. These results implicate miR-27b as a novel regulator of cyclin T1 protein levels and HIV-1 replication,. HHID00011325 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-29c(hsa-miR-29c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000735 - - Host Protein CCNT1 http://www.ncbi.nlm.nih.gov/gene/904 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011326 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-29c(hsa-miR-29c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000735 - - Host Protein CDC42 http://www.ncbi.nlm.nih.gov/gene/998 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011327 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-29c(hsa-miR-29c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000735 - - Host Protein DNMT3A http://www.ncbi.nlm.nih.gov/gene/1788 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011328 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-29c(hsa-miR-29c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000735 - - Host Protein DNMT3B http://www.ncbi.nlm.nih.gov/gene/1789 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011329 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-29c(hsa-miR-29c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000735 - - Host Protein MCL1(Mcl-1) http://www.ncbi.nlm.nih.gov/gene/4170 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011330 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-29c(hsa-miR-29c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000735 - - Host Protein P85a http://www.ncbi.nlm.nih.gov/gene/5295 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011331 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-29c(hsa-miR-29c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000735 - - Host Protein RISC http://www.ncbi.nlm.nih.gov/gene/59342 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011332 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-29c(hsa-miR-29c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000735 - - Host Protein TCL1A http://www.ncbi.nlm.nih.gov/gene/8115 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011333 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-29c-5p(hsa-miR-29c*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004673 - - Host Protein CCNT1 http://www.ncbi.nlm.nih.gov/gene/904 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011334 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-29c-5p(hsa-miR-29c*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004673 - - Host Protein CDC42 http://www.ncbi.nlm.nih.gov/gene/998 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011335 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-29c-5p(hsa-miR-29c*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004673 - - Host Protein DNMT3A http://www.ncbi.nlm.nih.gov/gene/1788 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011336 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-29c-5p(hsa-miR-29c*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004673 - - Host Protein DNMT3B http://www.ncbi.nlm.nih.gov/gene/1789 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011337 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-29c-5p(hsa-miR-29c*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004673 - - Host Protein MCL1(Mcl-1) http://www.ncbi.nlm.nih.gov/gene/4170 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011338 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-29c-5p(hsa-miR-29c*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004673 - - Host Protein P85a http://www.ncbi.nlm.nih.gov/gene/5295 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011339 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-29c-5p(hsa-miR-29c*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004673 - - Host Protein RISC http://www.ncbi.nlm.nih.gov/gene/59342 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011340 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-29c-5p(hsa-miR-29c*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004673 - - Host Protein TCL1A http://www.ncbi.nlm.nih.gov/gene/8115 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011341 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-548d-5p(miR-548d-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004812 HEK293T cells - Host Protein IL1B(IL-1) http://www.ncbi.nlm.nih.gov/gene/3553 Upregulation Validation of differentially regulated miRNA and mRNA from the genome-wide array, Microarray data analysis, MiRNA profiling using RT2 MicroRNA PCR Array, Computational analysis validating the miRNA targets and mRNAs, Gene expression profiling. 21829495 Comparative expression profile of miRNA and mRNA in primary peripheral blood mononuclear cells infected with human immunodeficiency virus (HIV-1). Our interaction analyses indicate that IL-1beta could potentially be regulated by miR-211, miR-578, and miR-548d-5p. HHID00011342 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-101(miR-101) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000103 brain microvascular endothelial cells (BMVECs) Upregulation Host Protein CDH5 http://www.ncbi.nlm.nih.gov/gene/1003 Downregulation Luciferase reporter assays. 23554480 We have demonstrated that VE-cadherin is a direct target of miR-101 using a luciferase reporter assay, which showed that mutated VE-cadherin 3'UTR and miR-101 cotransfection did not change luciferase activity.We have identified HIV-1 Tat C-induced disruption of VE-cadherin mediated by miRNA-101 in human brain microvascular endothelial cells (BMVECs). HIV-1 Tat C increased the expression of miR-101, which led to downregulation of VE-cadherin. Overexpression of miR-101 resulted into the suppression of VE-cadherin. Inhibition of miR-101 by the miRNA inhibitor enhanced the expression of VE-cadherin. HHID00011343 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-106b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000734 Human peripheral blood mononuclear cells - Host Protein PURA http://www.ncbi.nlm.nih.gov/gene/5813 Downregulation Reporter assay, RNAhybrid. 23043098 A further set of six miRNAs(miR-15a, miR-15b, miR-16, miR-20a, miR-93, and miR-106b)were reported to repress the expression of a third Tat cofactor, PURA, which was noted also to be enriched in monocytes. HHID00011344 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-125a(miR-125a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000469 - - Host Protein IFITM3 http://www.ncbi.nlm.nih.gov/gene/10410 Downregulation - 21786074 Table1 Functions of cellular miRNAs identified in HIV.Protein translation of IFITM3 and sTNFR1A.Table 1 summarizes the list of cellular miRNAs identified in relation to HIV/AIDS, the functions of which are discussed in this review. HHID00011345 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-125b(miR-125b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000446 Human monocytes Upregulation Host Protein TLR-3 http://www.ncbi.nlm.nih.gov/gene/7098 - Enzyme-linked immunosorbent assay for CC chemokines, Flow cytometric analysis, Real-time reverse transcription?polymerase chain reaction, Poly I:C treatment and HIV infection, Statistical analysis, HIV strains and reverse transcriptase assay. 20636339 Further more,TLR-3 activation in macrophages induced the expression of cellular microRNAs(miRNA-28, -125b, -150, -223 and -382), the newly identified intracellular HIV restriction factors. HHID00011346 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-128-1(miR-128a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000447 293T cells - Host Protein SNAP25 http://www.ncbi.nlm.nih.gov/gene/6616 Downregulation Quantitative RT-PCR, Immunohistochemistry, MicroRNA microarray, microRNA functional analysis, Western blots. 18381601 Inhibition of SNAP25 expression by HIV-1 Tat involves the activity of mir-128a. We further show that mir-128a inhibits expression of the pre-synaptic protein SNAP25, whereas the anti-mir-128a partially restores Tat/mir-128a-induced downregulation of SNAP25 expression. HHID00011347 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-146a(mir-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Fetal microglial cell Upregulation Host Protein CCL8(MCP-2) http://www.ncbi.nlm.nih.gov/gene/6355 Downregulation Dual luciferase assay, Quantitative RT-PCR, Immunohistochemistry, Statistics, miRNA functional analysis, ELISA assay, In situ hybridization. 20181935 We further show that CCL8/MCP-2 is a target for mir-146a in HIV-1 infected microglia, as overexpression of mir-146a prevented HIV-induced secretion of MCP-2 chemokine. HHID00011348 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-150(miR-150) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000479 Human monocytes Upregulation Host Protein TLR-3 http://www.ncbi.nlm.nih.gov/gene/7098 - Enzyme-linked immunosorbent assay for CC chemokines, Flow cytometric analysis, Real-time reverse transcription?polymerase chain reaction, Poly I:C treatment and HIV infection, Statistical analysis, HIV strains and reverse transcriptase assay. 20636339 Further more,TLR-3 activation in macrophages induced the expression of cellular microRNAs(miRNA-28, -125b, -150, -223 and -382), the newly identified intracellular HIV restriction factors. HHID00011349 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-150(miR-150) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000479 T cells - Host mRNA CCNT1(Cyclin T1) http://www.ncbi.nlm.nih.gov/gene/904 - Reporter assay, RNAhybrid. 23043098 They also found that, in different cellular contexts, other miRNAs regulate cyclin T1(e.g. miR-27b, miR-29b, miR-223, and miR-150), potentially explaining expression differences of HIV in resting versus activated T cells. HHID00011350 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 Human dendritic cell - Host Protein DC-SIGN http://www.ncbi.nlm.nih.gov/gene/30835 Downregulation - 21786074 Since miR-155 decreases dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin(DC-SIGN) expression, by downregulating transcription factor PU.1, miR-155 could be developed as a therapeutic target to prevent entrance of HIV through DC-SIGN binding. HHID00011351 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-15a(miR-15a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000069 Human peripheral blood mononuclear cells - Host Protein PURA http://www.ncbi.nlm.nih.gov/gene/5813 Downregulation Reporter assay, RNAhybrid. 23043098 A further set of six miRNAs(miR-15a, miR-15b, miR-16, miR-20a, miR-93, and miR-106b)were reported to repress the expression of a third Tat cofactor, PURA, which was noted also to be enriched in monocytes. HHID00011352 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-15b(miR-15b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000438 Human peripheral blood mononuclear cells - Host Protein PURA http://www.ncbi.nlm.nih.gov/gene/5813 Downregulation Reporter assay, RNAhybrid. 23043098 A further set of six miRNAs(miR-15a, miR-15b, miR-16, miR-20a, miR-93, and miR-106b)were reported to repress the expression of a third Tat cofactor, PURA, which was noted also to be enriched in monocytes. HHID00011353 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-16(miR-16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000070 Human peripheral blood mononuclear cells - Host Protein PURA http://www.ncbi.nlm.nih.gov/gene/5813 Downregulation Reporter assay, RNAhybrid. 23043098 A further set of six miRNAs(miR-15a, miR-15b, miR-16, miR-20a, miR-93, and miR-106b)were reported to repress the expression of a third Tat cofactor, PURA, which was noted also to be enriched in monocytes. HHID00011354 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-198 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000240 lymphocyte Upregulation Host Protein CCNT1(cyclin T1) http://www.ncbi.nlm.nih.gov/gene/904 Downregulation Infection and flow cytometry, Transfection Microarray probes, hybridization and analysis, Reverse transcription and real-time PCR. 21569500 Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1. On the other hand, the level of hsa-miR-198, which targets cyclin T1 [The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control62], is upregulated by all three HIV-1NL4-3 strains tested in this study. Cyclin T1 also acts as a cofactor for Tat transcriptional trans-activation, and upregulation of hsa-miR-198 could reduce cyclin T1 levels. HHID00011355 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-198(miR-198) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000240 Peripheral blood mononuclear cells - Host Protein CCNT1(Cyclin T1) http://www.ncbi.nlm.nih.gov/gene/904 Downregulation TaqMan MicroRNA assays, dual-luciferase assays, LTR-luciferase reporter assays, quantification, RT-real-time-PCR, plasmid reporter assays, End-point PCR analysis, Dual-Luciferase Reporter Assay System, and target prediction, reporter assay, MiRNA microarray analysis. 19148268 Our data indicate that miR-198 functions to restrict HIV-1 replication in monocytes, and its mechanism of action appears to involve repression of Cyclin T1 expression. HHID00011356 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-198(miR-198) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000240 T cells - Host mRNA CCNT1(Cyclin T1) http://www.ncbi.nlm.nih.gov/gene/904 - Reporter assay, RNAhybrid. 23043098 Sungand Rice(43) found that miR-198 targets the cyclin T1 mRNA, which encodes a HIV-1 Tat cofactor. They also found that, in different cellular contexts, other miRNAs regulate cyclin T1(e.g. miR-27b, miR-29b, miR-223, and miR-150), potentially explaining expression differences of HIV in resting versus activated T cells. HHID00011357 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-20a(hsa-miR-20a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000076 lymphocyte Downregulation Host mRNA KAT2B(PCAF) http://www.ncbi.nlm.nih.gov/gene/8850 - Infection and flow cytometry, Transfection Microarray probes, hybridization and analysis, Reverse transcription and real-time PCR. 21569500 Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1. Two members of the hsa-miR-17/92 cluster, hsa-miR-17-5p and hsa-miR-20a, target the mRNA of the PCAF cofactor of Tat trans-activation. Our results and published microarrays agree in downregulation of these miRNA by HIV-1. HHID00011358 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-20a(miR-20a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000076 - - Host Protein PURA http://www.ncbi.nlm.nih.gov/gene/5813 Downregulation Reporter assay, RNAhybrid. 23043098 A further set of six miRNAs(miR-15a, miR-15b, miR-16, miR-20a, miR-93, and miR-106b)were reported to repress the expression of a third Tat cofactor, PURA , which was noted also to be enriched in monocytes. HHID00011359 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-211(miR-211) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000287 HEK293T cells - Host Protein IL1B(IL-1) http://www.ncbi.nlm.nih.gov/gene/3553 Downregulation Validation of differentially regulated miRNA and mRNA from the genome-wide array, Microarray data analysis, MiRNA profiling using RT2 MicroRNA PCR Array, Computational analysis validating the miRNA targets and mRNAs, Gene expression profiling. 21829495 Comparative expression profile of miRNA and mRNA in primary peripheral blood mononuclear cells infected with human immunodeficiency virus (HIV-1). Our interaction analyses indicate that IL-1beta could potentially be regulated by miR-211, miR-578, and miR-548d-5p. HHID00011360 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-217 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000293 - - Host Protein SIRT1(SIRT-1) http://www.ncbi.nlm.nih.gov/gene/23411 Upregulation Luciferase assays. 23043098 In a converse example, Zhang et al. found that miR-217 was induced by Tat and that miR-217 increased HIV-1 expression by targeting SIRT-1(sirtuin-1), a host protein that deacetylates and inactivates Tat function. HHID00011361 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-223(hsa-mir-223) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000300 - - Host Protein APOBEC3F http://www.ncbi.nlm.nih.gov/gene/200316 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011362 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-223(hsa-mir-223) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000300 - - Host Protein APOBEC3G http://www.ncbi.nlm.nih.gov/gene/60489 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011363 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-223(hsa-mir-223) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000300 - - Host Protein CCNT1 http://www.ncbi.nlm.nih.gov/gene/904 - - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011364 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-223(hsa-mir-223) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000300 - - Host Protein LIF http://www.ncbi.nlm.nih.gov/gene/3976 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011365 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-223(hsa-mir-223) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000300 - - Host Protein RhoB http://www.ncbi.nlm.nih.gov/gene/388 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011366 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-223(hsa-mir-223) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000300 - - Host Protein SP3 http://www.ncbi.nlm.nih.gov/gene/6670 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011367 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-223(miR-223) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000300 - - Host Protein LIF http://www.ncbi.nlm.nih.gov/gene/3976 Downregulation Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 Therefore miR-223 could function as a negative factor in HIV-1 infection by reducing RhoB mediated activation of the AKT-NFKB pathway. This miRNA could also function as a positive factor in HIV-1 infection via targeting HIV-1 suppressive Sp3 and LIF. HHID00011368 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-223(miR-223) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000300 - - Host Protein RhoB http://www.ncbi.nlm.nih.gov/gene/388 Downregulation Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 Therefore miR-223 could function as a negative factor in HIV-1 infection by reducing RhoB mediated activation of the AKT-NFKB pathway. This miRNA could also function as a positive factor in HIV-1 infection via targeting HIV-1 suppressive Sp3 and LIF. HHID00011369 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-223(miR-223) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000300 - - Host Protein SP3 http://www.ncbi.nlm.nih.gov/gene/6670 Downregulation Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 Therefore miR-223 could function as a negative factor in HIV-1 infection by reducing RhoB mediated activation of the AKT-NFKB pathway. This miRNA could also function as a positive factor in HIV-1 infection via targeting HIV-1 suppressive Sp3 and LIF. HHID00011370 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-223(miR-223) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000300 Human monocytes Upregulation Host Protein TLR-3 http://www.ncbi.nlm.nih.gov/gene/7098 - Enzyme-linked immunosorbent assay for CC chemokines, Flow cytometric analysis, Real-time reverse transcription?polymerase chain reaction, Poly I:C treatment and HIV infection, Statistical analysis, HIV strains and reverse transcriptase assay. 20636339 Further more,TLR-3 activation in macrophages induced the expression of cellular microRNAs(miRNA-28, -125b, -150, -223 and -382), the newly identified intracellular HIV restriction factors. HHID00011371 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-223(miR-223) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000300 T cells - Host mRNA CCNT1(Cyclin T1) http://www.ncbi.nlm.nih.gov/gene/904 - Reporter assay, RNAhybrid. 23043098 Other miRNAs regulate cyclin T1(e.g. miR-27b, miR-29b, miR-223, and miR-150), potentially explaining expression differences of HIV in resting versus activated T cells. HHID00011372 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-27b(miR-27b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000440 CD4+ T lymphocytes - Host Protein DNMT3A http://www.ncbi.nlm.nih.gov/gene/1788 Upregulation Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 MiR-29 targets include Mcl-1, DNMT 3A/B, Tcl1, p85 (the regulatory subunit of PI3 kinase) and CDC42. Upregulation of DNMT 3A/B may trigger global DNA methylation thereby epigenetically silencing expression of immune system genes involved in the host viral defense mechanism (54). Intriguingly, upregulated DNMT 3A/B may also methylate the LTR region of integrated HIV-1 thereby silencing the viral LTR promoter activity, which could contribute to HIV-1 latency. HHID00011373 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-27b(miR-27b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000440 CD4+ T lymphocytes - Host Protein DNMT3B http://www.ncbi.nlm.nih.gov/gene/1789 Upregulation Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 MiR-29 targets include Mcl-1, DNMT 3A/B, Tcl1, p85 (the regulatory subunit of PI3 kinase) and CDC42. Upregulation of DNMT 3A/B may trigger global DNA methylation thereby epigenetically silencing expression of immune system genes involved in the host viral defense mechanism (54). Intriguingly, upregulated DNMT 3A/B may also methylate the LTR region of integrated HIV-1 thereby silencing the viral LTR promoter activity, which could contribute to HIV-1 latency. HHID00011374 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-27b(miR-27b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000440 CD4+ T lymphocytes - Host Protein MCL1(Mcl-1) http://www.ncbi.nlm.nih.gov/gene/4170 Downregulation Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 MiR-29 targets include Mcl-1, DNMT 3A/B, Tcl1, p85 (the regulatory subunit of PI3 kinase) and CDC42 (45-48). Mcl1 is an anti-apoptosis protein and its overexpression results in B cell lymphomas (49). This protein could be upregulated during HIV-1 infection to inhibit viral triggered apoptosis. HHID00011375 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-27b(miR-27b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000440 CD4+ T lymphocytes - Host Protein P85a http://www.ncbi.nlm.nih.gov/gene/5295 Downregulation Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 Interplay between HIV-1 infection and host microRNAs. By targeting P85a and CDC42, miR-29 can upregulate p53 levels and induce apoptosis in a p53-dependent manner. HHID00011376 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-27b(miR-27b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000440 CD4+ T lymphocytes - Host Protein TCL1A(Tcl1) http://www.ncbi.nlm.nih.gov/gene/8115 Upregulation Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 MiR-29 targets include Mcl-1, DNMT 3A/B, Tcl1, p85 (the regulatory subunit of PI3 kinase) and CDC42. Tcl1 is an AKT kinase coactivator that can enhance AKT kinase activity (55-57), possibly facilitating HIV-1 infection when upregulated. HHID00011377 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-27b(miR-27b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000440 CD4+ T lymphocytes - Host mRNA CCNT1(cyclin T1) http://www.ncbi.nlm.nih.gov/gene/904 - Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 Interplay between HIV-1 infection and host microRNAs. Furthermore, we show that miR-27b inhibits viral replication via the direct targeting of cyclin T1 mRNA and, along with miR-29b, mediates the targeting of cyclin T1 mRNA to the RISC. HHID00011378 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-27b(miR-27b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000440 T cells - Host mRNA CCNT1(Cyclin T1) http://www.ncbi.nlm.nih.gov/gene/904 - Reporter assay, RNAhybrid. 23043098 Other miRNAs regulate cyclin T1(e.g. miR-27b, miR-29b, miR-223, and miR-150), potentially explaining expression differences of HIV in resting versus activated T cells. HHID00011379 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-28(miRNA-28) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000086 Human monocytes Upregulation Host Protein TLR-3 http://www.ncbi.nlm.nih.gov/gene/7098 - Enzyme-linked immunosorbent assay for CC chemokines, Flow cytometric analysis, Real-time reverse transcription?polymerase chain reaction, Poly I:C treatment and HIV infection, Statistical analysis, HIV strains and reverse transcriptase assay. 20636339 Further more,TLR-3 activation in macrophages induced the expression of cellular microRNAs(miRNA-28, -125b, -150, -223 and -382), the newly identified intracellular HIV restriction factors. HHID00011380 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-29a(miR-29) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000087 CD4+ T lymphocytes - Host Protein CDC42 http://www.ncbi.nlm.nih.gov/gene/998 Upregulation Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 Interplay between HIV-1 infection and host microRNAs. By targeting P85a and CDC42, miR-29 can upregulate p53 levels and induce apoptosis in a p53-dependent manner. HHID00011381 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-29a(miR-29) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000087 CD4+ T lymphocytes - Host Protein DNMT3A http://www.ncbi.nlm.nih.gov/gene/1788 Upregulation Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 MiR-29 targets include Mcl-1, DNMT 3A/B, Tcl1, p85 (the regulatory subunit of PI3 kinase) and CDC42. Upregulation of DNMT 3A/B may trigger global DNA methylation thereby epigenetically silencing expression of immune system genes involved in the host viral defense mechanism (54). Intriguingly, upregulated DNMT 3A/B may also methylate the LTR region of integrated HIV-1 thereby silencing the viral LTR promoter activity, which could contribute to HIV-1 latency. HHID00011382 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-29a(miR-29) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000087 CD4+ T lymphocytes - Host Protein DNMT3B http://www.ncbi.nlm.nih.gov/gene/1789 Upregulation Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 MiR-29 targets include Mcl-1, DNMT 3A/B, Tcl1, p85 (the regulatory subunit of PI3 kinase) and CDC42. Upregulation of DNMT 3A/B may trigger global DNA methylation thereby epigenetically silencing expression of immune system genes involved in the host viral defense mechanism (54). Intriguingly, upregulated DNMT 3A/B may also methylate the LTR region of integrated HIV-1 thereby silencing the viral LTR promoter activity, which could contribute to HIV-1 latency. HHID00011383 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-29a(miR-29) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000087 CD4+ T lymphocytes - Host Protein MCL1(Mcl-1) http://www.ncbi.nlm.nih.gov/gene/4170 Downregulation Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 MiR-29 targets include Mcl-1, DNMT 3A/B, Tcl1, p85 (the regulatory subunit of PI3 kinase) and CDC42 (45-48). Mcl1 is an anti-apoptosis protein and its overexpression results in B cell lymphomas (49). This protein could be upregulated during HIV-1 infection to inhibit viral triggered apoptosis. HHID00011384 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-29a(miR-29) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000087 CD4+ T lymphocytes - Host Protein P85a http://www.ncbi.nlm.nih.gov/gene/5295 Downregulation Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 Interplay between HIV-1 infection and host microRNAs. By targeting P85a and CDC42, miR-29 can upregulate p53 levels and induce apoptosis in a p53-dependent manner. HHID00011385 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-29a(miR-29) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000087 CD4+ T lymphocytes - Host Protein TCL1A(Tcl1) http://www.ncbi.nlm.nih.gov/gene/8115 Upregulation Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 MiR-29 targets include Mcl-1, DNMT 3A/B, Tcl1, p85 (the regulatory subunit of PI3 kinase) and CDC42. Tcl1 is an AKT kinase coactivator that can enhance AKT kinase activity (55-57), possibly facilitating HIV-1 infection when upregulated. HHID00011386 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-29b(miR-29) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000105 CD4+ T lymphocytes - Host Protein CDC42 http://www.ncbi.nlm.nih.gov/gene/998 Upregulation Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 Interplay between HIV-1 infection and host microRNAs. By targeting P85a and CDC42, miR-29 can upregulate p53 levels and induce apoptosis in a p53-dependent manner. HHID00011387 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-29b(miR-29b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000105 CD4+ T lymphocytes - Host mRNA CCNT1(cyclin T1) http://www.ncbi.nlm.nih.gov/gene/904 - Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 Interplay between HIV-1 infection and host microRNAs. Furthermore, we show that miR-27b inhibits viral replication via the direct targeting of cyclin T1 mRNA and, along with miR-29b, mediates the targeting of cyclin T1 mRNA to the RISC. HHID00011388 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-29b(miR-29b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000105 T cells - Host mRNA CCNT1(Cyclin T1) http://www.ncbi.nlm.nih.gov/gene/904 - Reporter assay, RNAhybrid. 23043098 Other miRNAs regulate cyclin T1(e.g. miR-27b, miR-29b, miR-223, and miR-150), potentially explaining expression differences of HIV in resting versus activated T cells. HHID00011389 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-29c(miR-29) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000735 CD4+ T lymphocytes - Host Protein CDC42 http://www.ncbi.nlm.nih.gov/gene/998 Upregulation Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 Interplay between HIV-1 infection and host microRNAs. By targeting P85a and CDC42, miR-29 can upregulate p53 levels and induce apoptosis in a p53-dependent manner. HHID00011390 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-29c(miR-29) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000735 CD4+ T lymphocytes - Host Protein DNMT3A http://www.ncbi.nlm.nih.gov/gene/1788 Upregulation Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 MiR-29 targets include Mcl-1, DNMT 3A/B, Tcl1, p85 (the regulatory subunit of PI3 kinase) and CDC42. Upregulation of DNMT 3A/B may trigger global DNA methylation thereby epigenetically silencing expression of immune system genes involved in the host viral defense mechanism (54). Intriguingly, upregulated DNMT 3A/B may also methylate the LTR region of integrated HIV-1 thereby silencing the viral LTR promoter activity, which could contribute to HIV-1 latency. HHID00011391 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-29c(miR-29) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000735 CD4+ T lymphocytes - Host Protein DNMT3B http://www.ncbi.nlm.nih.gov/gene/1789 Upregulation Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 MiR-29 targets include Mcl-1, DNMT 3A/B, Tcl1, p85 (the regulatory subunit of PI3 kinase) and CDC42. Upregulation of DNMT 3A/B may trigger global DNA methylation thereby epigenetically silencing expression of immune system genes involved in the host viral defense mechanism (54). Intriguingly, upregulated DNMT 3A/B may also methylate the LTR region of integrated HIV-1 thereby silencing the viral LTR promoter activity, which could contribute to HIV-1 latency. HHID00011392 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-29c(miR-29) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000735 CD4+ T lymphocytes - Host Protein MCL1(Mcl-1) http://www.ncbi.nlm.nih.gov/gene/4170 Downregulation Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 MiR-29 targets include Mcl-1, DNMT 3A/B, Tcl1, p85 (the regulatory subunit of PI3 kinase) and CDC42 (45-48). Mcl1 is an anti-apoptosis protein and its overexpression results in B cell lymphomas (49). This protein could be upregulated during HIV-1 infection to inhibit viral triggered apoptosis. HHID00011393 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-29c(miR-29) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000735 CD4+ T lymphocytes - Host Protein P85a http://www.ncbi.nlm.nih.gov/gene/5295 Downregulation Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 Interplay between HIV-1 infection and host microRNAs. By targeting P85a and CDC42, miR-29 can upregulate p53 levels and induce apoptosis in a p53-dependent manner. HHID00011394 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-29c(miR-29) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000735 CD4+ T lymphocytes - Host Protein TCL1A(Tcl1) http://www.ncbi.nlm.nih.gov/gene/8115 Upregulation Dual Luciferase reporter assays, Immunobloting, MiRNA quantification with TaqMan? MicroRNA Assay, RNA isolation, Lentivirus production, Cell cycle analysis, northern blot. 22080513 MiR-29 targets include Mcl-1, DNMT 3A/B, Tcl1, p85 (the regulatory subunit of PI3 kinase) and CDC42. Tcl1 is an AKT kinase coactivator that can enhance AKT kinase activity (55-57), possibly facilitating HIV-1 infection when upregulated. HHID00011395 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-31(miR-31) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000089 CD4+ T-cell Downregulation Host Protein SATB2 http://www.ncbi.nlm.nih.gov/gene/23314 - TLDA profiling. 22240256 miRNA profiles, obtained using multiple acquisition, data processing, and analysis methods, distinguished ES and uninfected controls from viremic HIV-1-infected patients. Differentially expressed miRNAs included those with reported roles in HIV-1 latency (miR-29 family members, miRs -125b and -150). Others, such as miR-31 and miR-31*, had no previously reported connection with HIV-1 infection but were found here to differ significantly with uncontrolled HIV-1 replication. The validated target of miR-31, the special AT-rich binding protein 2 (SATB2) [The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control43], is part of a gene regulatory family needed for differentiation within the T-cell lineage. HHID00011396 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-34a(hsa-mir-34a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000268 - - Host Protein CREBBP http://www.ncbi.nlm.nih.gov/gene/1387 - - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011397 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-34a(hsa-mir-34a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000268 - - Host Protein CREBBP http://www.ncbi.nlm.nih.gov/gene/1387 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HHID00011398 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-382(miR-382) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000790 Human monocytes Upregulation Host Protein TLR-3 http://www.ncbi.nlm.nih.gov/gene/7098 - Enzyme-linked immunosorbent assay for CC chemokines, Flow cytometric analysis, Real-time reverse transcription?polymerase chain reaction, Poly I:C treatment and HIV infection, Statistical analysis, HIV strains and reverse transcriptase assay. 20636339 Further more,TLR-3 activation in macrophages induced the expression of cellular microRNAs(miRNA-28, -125b, -150, -223 and -382), the newly identified intracellular HIV restriction factors. HHID00011399 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-578(miR-578) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003585 HEK293T cells - Host Protein IL1B(IL-1) http://www.ncbi.nlm.nih.gov/gene/3553 Upregulation Validation of differentially regulated miRNA and mRNA from the genome-wide array, Microarray data analysis, MiRNA profiling using RT2 MicroRNA PCR Array, Computational analysis validating the miRNA targets and mRNAs, Gene expression profiling. 21829495 Comparative expression profile of miRNA and mRNA in primary peripheral blood mononuclear cells infected with human immunodeficiency virus (HIV-1). Our interaction analyses indicate that IL-1beta could potentially be regulated by miR-211, miR-578, and miR-548d-5p. HHID00011400 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-93(miR-93) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000095 Human peripheral blood mononuclear cells - Host Protein PURA http://www.ncbi.nlm.nih.gov/gene/5813 Downregulation Reporter assay, RNAhybrid. 23043098 Afurther set of six miRNAs(miR-15a, miR-15b, miR-16, miR-20a, miR-93, and miR-106b)were reported to repress the expression of a third Tat cofactor, PURA, which was noted also to be enriched in monocytes. HHID00011401 Human papillomavirus 16(HPV16) Homo sapiens Host miRNA hsa-mir-203a(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000283 - Upregulation Host Protein TP53(p53) http://www.ncbi.nlm.nih.gov/gene/7157 - Western blot analysis, microRNA real-time PCR, Reverse transcription-PCR (RT-PCR) analysis, Northern blotting for microRNAs, Immunofluorescence staining and analysis. 20702634 In summary, these results indicate that expression of miR-203 is dependent on p53, which may explain how expression of HPV16 E6 can disrupt the balance between proliferation and differentiation, as well as the response to DNA damage, in keratinocytes. HHID00011402 Human papillomavirus 16(HPV16) Homo sapiens Host miRNA hsa-mir-203b(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0017343 - Upregulation Host Protein TP53(p53) http://www.ncbi.nlm.nih.gov/gene/7157 - Western blot analysis, microRNA real-time PCR, Reverse transcription-PCR (RT-PCR) analysis, Northern blotting for microRNAs, Immunofluorescence staining and analysis. 20702634 In summary, these results indicate that expression of miR-203 is dependent on p53, which may explain how expression of HPV16 E6 can disrupt the balance between proliferation and differentiation, as well as the response to DNA damage, in keratinocytes. HHID00011403 Human papillomavirus(HPV) Homo sapiens Host miRNA hsa-mir-128(miR128) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000447 Cervical lesions Downregulation Host Protein LAMB3 http://www.ncbi.nlm.nih.gov/gene/3914 Upregulation MicroRNA and mRNA real-time quantitative RT-PCR analysis, MicroRNA Northern blot analysis, MicroRNA microarray analysis, Western blot analysis. 17998940 Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells.We also demonstrate that the epithelial cell-specific marker LAMB3 is a target of miR-218. HHID00011404 Human papillomavirus(HPV) Homo sapiens Host miRNA hsa-mir-203a(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000283 Foreskin keratinocytes - Host Protein P63 http://www.ncbi.nlm.nih.gov/gene/10970 - QRT-PCR, Luciferase assay, Northern blot analysis, Western blot analysis, Southern blot analysis. 20219920 Human papillomaviruses modulate expression of microRNA 203 upon epithelial differentiation to control levels of p63 proteins. One target of miR-203 is the p63 family of transcription factors. HHID00011405 Human papillomavirus(HPV) Homo sapiens Host miRNA hsa-mir-203b(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0017343 Foreskin keratinocytes - Host Protein P63 http://www.ncbi.nlm.nih.gov/gene/10970 - QRT-PCR, Luciferase assay, Northern blot analysis, Western blot analysis, Southern blot analysis. 20219920 Human papillomaviruses modulate expression of microRNA 203 upon epithelial differentiation to control levels of p63 proteins. One target of miR-203 is the p63 family of transcription factors. HHID00011406 Human papillomavirus(HPV) Homo sapiens Host miRNA hsa-mir-218(miR-218) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000294 Cervical squamous cell Downregulation Host Protein LAMB3 http://www.ncbi.nlm.nih.gov/gene/3914 Upregulation silico analysis. 23483249 Cervical squamous cell carcinoma (cervical SCC), one of the most frequent types of cervical cancers, is associated with high-risk human papilloma virus (HPV). These data indicated that miR-218 acts as a tumor suppressor in cervical SCC. Our in silico analysis showed that miR-218 appeared to be an important modulator of tumor cell processes through suppression of many targets, particularly those involved in focal adhesion signaling pathways.Gene expression data indicated that LAMB3, a laminin protein known to influence cell differentiation, migration, adhesion, proliferation and survival, was upregulated in cervical SCC clinical specimens, and silencing studies demonstrated that LAMB3 functioned as an oncogene in cervical SCC. HHID00011407 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-let-7g(let-7g) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000433 Peripheral blood mononuclear cells - Host Protein MAPK11 http://www.ncbi.nlm.nih.gov/gene/5600 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients. HHID00011408 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-let-7g(let-7g) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000433 Peripheral blood mononuclear cells - Host Protein MAPK13 http://www.ncbi.nlm.nih.gov/gene/5603 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients. HHID00011409 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-let-7g(let-7g) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000433 Peripheral blood mononuclear cells - Host Protein MAPK14 http://www.ncbi.nlm.nih.gov/gene/1432 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients. HHID00011410 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-let-7g(let-7g) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000433 Peripheral blood mononuclear cells Downregulation Host Protein CASP3(caspase-3) http://www.ncbi.nlm.nih.gov/gene/836 Upregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 In our study, CASP3 was significantly upregulated by qRT-PCR analysis(Figure 6) and targeted by the downregulated miRNAs: miR-342-3p, miR-29b, miR-29c, miR-29a, let-7g and miR-34b, which can be expected to develop miRNA-based therapeutics for influenza. HHID00011411 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-let-7g(let-7g) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000433 Peripheral blood mononuclear cells Downregulation Host Protein EGFR http://www.ncbi.nlm.nih.gov/gene/1956 Upregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 We found that EGFR was regulated by miR-342, miR-155, miR-30b, miR-210, miR-192, let-7g, and miR-146b-5p, which were all down expressed in H1N1 critically ill patients.These downregulated miRNAs can upregulate EGFR expression, resulting in easier virus replication and propagation at the early stage of infection. . HHID00011412 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-miR-29c(miR-29c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000735 Peripheral blood mononuclear cells Downregulation Host Protein CASP3(caspase-3) http://www.ncbi.nlm.nih.gov/gene/836 Upregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 In our study, CASP3 was significantly upregulated by qRT-PCR analysis(Figure 6) and targeted by the downregulated miRNAs: miR-342-3p, miR-29b, miR-29c, miR-29a, let-7g and miR-30b, which can be expected to develop miRNA-based therapeutics for influenza disease. HHID00011413 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-1281(miR-1281) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006428 A549 cells - Host mRNA RAB4B http://www.ncbi.nlm.nih.gov/gene/53916 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011414 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-1281(miR-1281) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006429 A549 cells - Host mRNA FCGBP http://www.ncbi.nlm.nih.gov/gene/8857 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011415 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-1281(miR-1281) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006429 A549 cells - Host mRNA FGA http://www.ncbi.nlm.nih.gov/gene/2243 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011416 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-1281(miR-1281) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006429 A549 cells - Host mRNA SMOC1 http://www.ncbi.nlm.nih.gov/gene/64093 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011417 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-1281(miR-1281) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006429 A549 cells - Host mRNA TRIM9 http://www.ncbi.nlm.nih.gov/gene/114088 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011418 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-1281(miR-1281) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006430 A549 cells - Host mRNA TCN1 http://www.ncbi.nlm.nih.gov/gene/6947 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011419 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-1281(miR-1281) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006431 A549 cells - Host mRNA SLC29A4 http://www.ncbi.nlm.nih.gov/gene/222962 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011420 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-1281(miR-1281) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006432 A549 cells - Host mRNA CA9 http://www.ncbi.nlm.nih.gov/gene/768 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011421 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-1281(miR-1281) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006433 A549 cells - Host mRNA MUC5AC http://www.ncbi.nlm.nih.gov/gene/4586 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011422 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-1281(miR-1281) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006434 A549 cells - Host mRNA KIAA1199 http://www.ncbi.nlm.nih.gov/gene/57214 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011423 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-1281(miR-1281) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006435 A549 cells - Host mRNA C6orf117 http://www.ncbi.nlm.nih.gov/gene/112609 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011424 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-1281(miR-1281) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006436 A549 cells - Host mRNA SLC16A3 http://www.ncbi.nlm.nih.gov/gene/9123 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011425 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-1281(miR-1281) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006437 A549 cells - Host mRNA CHGB http://www.ncbi.nlm.nih.gov/gene/1114 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011426 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-1281(miR-1281) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006438 A549 cells - Host mRNA C10orf11 http://www.ncbi.nlm.nih.gov/gene/83938 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011427 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-1281(miR-1281) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006439 A549 cells - Host mRNA STEAP1 http://www.ncbi.nlm.nih.gov/gene/26872 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011428 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-138-1(miR-138-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000476 A549 cells - Host mRNA CPS1 http://www.ncbi.nlm.nih.gov/gene/1373 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011429 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-138-1(miR-138-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000476 A549 cells - Host mRNA FGA http://www.ncbi.nlm.nih.gov/gene/2243 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011430 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-138-1(miR-138-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000476 A549 cells - Host mRNA LGSN http://www.ncbi.nlm.nih.gov/gene/51557 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011431 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-138-1(miR-138-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000476 A549 cells - Host mRNA OCEL1 http://www.ncbi.nlm.nih.gov/gene/79629 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011432 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-138-1(miR-138-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000476 A549 cells - Host mRNA PLD1 http://www.ncbi.nlm.nih.gov/gene/5337 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011433 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-138-1(miR-138-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000476 A549 cells - Host mRNA SCARA5 http://www.ncbi.nlm.nih.gov/gene/286133 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011434 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-138-1(miR-138-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000476 A549 cells - Host mRNA SMOC1 http://www.ncbi.nlm.nih.gov/gene/51557 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011435 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-138-1(miR-138-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000476 A549 cells - Host mRNA STC1 http://www.ncbi.nlm.nih.gov/gene/6781 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011436 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-138-1(miR-138-1) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000476 A549 cells - Host mRNA STEAP2 http://www.ncbi.nlm.nih.gov/gene/261729 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011437 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-141 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000457 Epithelial cells Upregulation Host Protein TGFB2(TGF-beta2) http://www.ncbi.nlm.nih.gov/gene/7042 Downregulation Enzyme-linked immunosorbent assay (ELISA), qRT-PCR, gene expression profiles. 23663545 Interestingly,we demonstrated that miR-141, which was more highly induced by H5N1 than by H1N1(p < 0.05), had an ability to suppress the expression of a cytokine - transforming growth factor(TGF)-beta2.Since TGF-beta2 is an important cytokine that can act as both an immunosuppressive agent and a potent proinflammatory molecule through its ability to attract and regulate inflammatory molecules, and previous report showed that only seasonal influenza H1N1(but not the other avian influenza subtypes) could induce a persistent expression of TGF-beta2, we speculate that the modulation of TGF-beta2 expression by different influenza subtypes via miR-141 might be a critical step for determining the outcome of either normal or excessive inflammation progression. HHID00011438 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein ABL2 http://www.ncbi.nlm.nih.gov/gene/27 Downregulation RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011439 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein BCL11A http://www.ncbi.nlm.nih.gov/gene/53335 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011440 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein BCORL1 http://www.ncbi.nlm.nih.gov/gene/63035 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011441 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein CARD10 http://www.ncbi.nlm.nih.gov/gene/29775 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011442 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein DNPEP http://www.ncbi.nlm.nih.gov/gene/23549 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011443 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein FLOT2 http://www.ncbi.nlm.nih.gov/gene/2319 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011444 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein GALNT10 http://www.ncbi.nlm.nih.gov/gene/55568 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011445 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein IRAK1(IRAK-1) http://www.ncbi.nlm.nih.gov/gene/3654 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011446 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein KBTBD3 http://www.ncbi.nlm.nih.gov/gene/143879 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011447 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein KDM6B(JMJD3) http://www.ncbi.nlm.nih.gov/gene/23135 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011448 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein LFNG http://www.ncbi.nlm.nih.gov/gene/3955 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011449 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein SLC2A3 http://www.ncbi.nlm.nih.gov/gene/6515 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011450 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein STRA13 http://www.ncbi.nlm.nih.gov/gene/201254 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011451 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein STRBP http://www.ncbi.nlm.nih.gov/gene/55342 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011452 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein SYT1 http://www.ncbi.nlm.nih.gov/gene/6857 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011453 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein ZNF532 http://www.ncbi.nlm.nih.gov/gene/55205 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011454 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-146b(miR-146b-5p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003129 Peripheral blood mononuclear cells - Host Protein MAPK11 http://www.ncbi.nlm.nih.gov/gene/5600 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients. HHID00011455 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-146b(miR-146b-5p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003129 Peripheral blood mononuclear cells - Host Protein MAPK13 http://www.ncbi.nlm.nih.gov/gene/5603 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients. HHID00011456 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-146b(miR-146b-5p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003129 Peripheral blood mononuclear cells - Host Protein MAPK14 http://www.ncbi.nlm.nih.gov/gene/1432 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients. HHID00011457 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-146b(miR-146b-5p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003129 Peripheral blood mononuclear cells Downregulation Host Protein EGFR http://www.ncbi.nlm.nih.gov/gene/1956 Upregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 We found that EGFR was regulated by miR-342, miR-155, miR-30b, miR-210, miR-192, let-7g, and miR-146b-5p, which were all down expressed in H1N1 critically ill patients.These downregulated miRNAs can upregulate EGFR expression, resulting in easier virus replication and propagation at the early stage of infection. . HHID00011458 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-148a(miR-148a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000253 Peripheral blood mononuclear cells - Host Protein TGFBR1 http://www.ncbi.nlm.nih.gov/gene/7046 Downregulation Predicted. 23731466 TGFBR1 and TP53 were both predicted to be regulated by high-expressed miR-148a.In our study, TGF-beta receptor 1 (TGFBR1) was found to be downregulated.TP53 was also found to be downregulated. . HHID00011459 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-148a(miR-148a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000253 Peripheral blood mononuclear cells - Host Protein TP53 http://www.ncbi.nlm.nih.gov/gene/7157 Downregulation Predicted. 23731466 TGFBR1 and TP53 were both predicted to be regulated by high-expressed miR-148a.In our study, TGF-beta receptor 1 (TGFBR1) was found to be downregulated.TP53 was also found to be downregulated. . HHID00011460 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 Peripheral blood mononuclear cells Downregulation Host Protein EGFR http://www.ncbi.nlm.nih.gov/gene/1956 Upregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 We found that EGFR was regulated by miR-342, miR-155, miR-30b, miR-210, miR-192, let-7g, and miR-146b-5p, which were all down expressed in H1N1 critically ill patients.These downregulated miRNAs can upregulate EGFR expression, resulting in easier virus replication and propagation at the early stage of infection. . HHID00011461 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-181a(miR-181a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000269 A549 cells - Host mRNA ATE1 http://www.ncbi.nlm.nih.gov/gene/11101 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011462 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-181a(miR-181a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000269 A549 cells - Host mRNA BIRC5 http://www.ncbi.nlm.nih.gov/gene/332 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011463 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-181a(miR-181a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000269 A549 cells - Host mRNA C4BPB http://www.ncbi.nlm.nih.gov/gene/725 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011464 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-181a(miR-181a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000269 A549 cells - Host mRNA CCNB1 http://www.ncbi.nlm.nih.gov/gene/891 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011465 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-181a(miR-181a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000269 A549 cells - Host mRNA EID3 http://www.ncbi.nlm.nih.gov/gene/493861 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011466 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-181a(miR-181a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000269 A549 cells - Host mRNA ETS1 http://www.ncbi.nlm.nih.gov/gene/2113 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011467 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-181a(miR-181a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000269 A549 cells - Host mRNA GTSE1 http://www.ncbi.nlm.nih.gov/gene/51512 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011468 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-181a(miR-181a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000269 A549 cells - Host mRNA INCENP http://www.ncbi.nlm.nih.gov/gene/3619 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011469 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-181a(miR-181a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000269 A549 cells - Host mRNA PSRC1 http://www.ncbi.nlm.nih.gov/gene/84722 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011470 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-181a(miR-181a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000269 A549 cells - Host mRNA RAD23B http://www.ncbi.nlm.nih.gov/gene/5887 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011471 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-181a(miR-181a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000269 A549 cells - Host mRNA SLC6A6 http://www.ncbi.nlm.nih.gov/gene/6533 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011472 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-181a(miR-181a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000269 A549 cells - Host mRNA STX11 http://www.ncbi.nlm.nih.gov/gene/8676 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011473 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-181a(miR-181a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000269 A549 cells - Host mRNA TPX2 http://www.ncbi.nlm.nih.gov/gene/22974 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011474 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-181a(miR-181a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000269 A549 cells - Host mRNA TUBA3D http://www.ncbi.nlm.nih.gov/gene/113457 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011475 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-192(miR-192) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000234 Peripheral blood mononuclear cells Downregulation Host Protein EGFR http://www.ncbi.nlm.nih.gov/gene/1956 Upregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 We found that EGFR was regulated by miR-342, miR-155, miR-30b, miR-210, miR-192, let-7g, and miR-146b-5p, which were all down expressed in H1N1 critically ill patients.These downregulated miRNAs can upregulate EGFR expression, resulting in easier virus replication and propagation at the early stage of infection. . HHID00011476 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-210(miR-210) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000286 Peripheral blood mononuclear cells Downregulation Host Protein EGFR http://www.ncbi.nlm.nih.gov/gene/1956 Upregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 We found that EGFR was regulated by miR-342, miR-155, miR-30b, miR-210, miR-192, let-7g, and miR-146b-5p, which were all down expressed in H1N1 critically ill patients.These downregulated miRNAs can upregulate EGFR expression, resulting in easier virus replication and propagation at the early stage of infection. . HHID00011477 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-210(miR-210) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000286 Peripheral blood mononuclear cells Downregulation Host mRNA Mx1 http://www.ncbi.nlm.nih.gov/gene/4599 Downregulation Predicted. 23731466 In our study, we found that Mx1 mRNA was significantly upregulated in H1N1 critically ill patients by qRT-PCR assay. No validated miRNA targeting Mx1 has been reported; thus,Our miRNA target prediction result indicated that Mx1 can be negatively regulated by miR-342-3p and miR-210, which were both down expressed in H1N1 critically ill patient. HHID00011478 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-29a(miR-29a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000087 Peripheral blood mononuclear cells Downregulation Host Protein CASP3(caspase-3) http://www.ncbi.nlm.nih.gov/gene/836 Upregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 In our study, CASP3 was significantly upregulated by qRT-PCR analysis(Figure 6) and targeted by the downregulated miRNAs: miR-342-3p, miR-29b, miR-29c, miR-29a, let-7g and miR-34b, which can be expected to develop miRNA-based therapeutics for influenza. HHID00011479 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-29b-1(miR-29b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000105 Peripheral blood mononuclear cells Downregulation Host Protein CASP3(caspase-3) http://www.ncbi.nlm.nih.gov/gene/836 Upregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 In our study, CASP3 was significantly upregulated by qRT-PCR analysis(Figure 6) and targeted by the downregulated miRNAs: miR-342-3p, miR-29b, miR-29c, miR-29a, let-7g and miR-34b, which can be expected to develop miRNA-based therapeutics for influenza. HHID00011480 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-29b-2(miR-29b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000105 Peripheral blood mononuclear cells Downregulation Host Protein CASP3(caspase-3) http://www.ncbi.nlm.nih.gov/gene/836 Upregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 In our study, CASP3 was significantly upregulated by qRT-PCR analysis(Figure 6) and targeted by the downregulated miRNAs: miR-342-3p, miR-29b, miR-29c, miR-29a, let-7g and miR-34b, which can be expected to develop miRNA-based therapeutics for influenza. HHID00011481 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30a(miR-30a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000088 A549 cells - Host mRNA AXL http://www.ncbi.nlm.nih.gov/gene/558 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011482 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30a(miR-30a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000088 A549 cells - Host mRNA BIRC3 http://www.ncbi.nlm.nih.gov/gene/330 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011483 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30a(miR-30a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000088 A549 cells - Host mRNA BU857004 http://www.ncbi.nlm.nih.gov/gene/6533 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011484 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30a(miR-30a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000088 A549 cells - Host mRNA CCNB2 http://www.ncbi.nlm.nih.gov/gene/9133 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011485 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30a(miR-30a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000088 A549 cells - Host mRNA CDCA8 http://www.ncbi.nlm.nih.gov/gene/55143 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011486 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30a(miR-30a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000088 A549 cells - Host mRNA DEPDC1B http://www.ncbi.nlm.nih.gov/gene/55789 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011487 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30a(miR-30a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000088 A549 cells - Host mRNA INCENP http://www.ncbi.nlm.nih.gov/gene/3619 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011488 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30a(miR-30a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000088 A549 cells - Host mRNA KIF11 http://www.ncbi.nlm.nih.gov/gene/3832 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011489 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30a(miR-30a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000088 A549 cells - Host mRNA RAD23B http://www.ncbi.nlm.nih.gov/gene/5887 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011490 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30a(miR-30a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000088 A549 cells - Host mRNA SLC6A6 http://www.ncbi.nlm.nih.gov/gene/6533 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011491 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30a(miR-30a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000088 A549 cells - Host mRNA ZCCHC16(MAR4) http://www.ncbi.nlm.nih.gov/gene/340595 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011492 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30b(miR-30b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000441 Peripheral blood mononuclear cells - Host Protein MAPK11 http://www.ncbi.nlm.nih.gov/gene/5600 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients. HHID00011493 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30b(miR-30b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000441 Peripheral blood mononuclear cells - Host Protein MAPK13 http://www.ncbi.nlm.nih.gov/gene/5603 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients. HHID00011494 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30b(miR-30b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000441 Peripheral blood mononuclear cells - Host Protein MAPK14 http://www.ncbi.nlm.nih.gov/gene/1432 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients. HHID00011495 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30b(miR-30b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000441 Peripheral blood mononuclear cells Downregulation Host Protein CASP3(caspase-3) http://www.ncbi.nlm.nih.gov/gene/836 Upregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 In our study, CASP3 was significantly upregulated by qRT-PCR analysis(Figure 6) and targeted by the downregulated miRNAs: miR-342-3p, miR-29b, miR-29c, miR-29a, let-7g and miR-34b, which can be expected to develop miRNA-based therapeutics for influenza. HHID00011496 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30b(miR-30b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000441 Peripheral blood mononuclear cells Downregulation Host Protein EGFR http://www.ncbi.nlm.nih.gov/gene/1956 Upregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 We found that EGFR was regulated by miR-342, miR-155, miR-30b, miR-210, miR-192, let-7g, and miR-146b-5p, which were all down expressed in H1N1 critically ill patients.These downregulated miRNAs can upregulate EGFR expression, resulting in easier virus replication and propagation at the early stage of infection. . HHID00011497 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30d(miR-30d) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000255 A549 cells - Host mRNA AXL http://www.ncbi.nlm.nih.gov/gene/558 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011498 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30d(miR-30d) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000255 A549 cells - Host mRNA BIRC3 http://www.ncbi.nlm.nih.gov/gene/330 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011499 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30d(miR-30d) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000255 A549 cells - Host mRNA BU857004 http://www.ncbi.nlm.nih.gov/gene/6533 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011500 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30d(miR-30d) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000255 A549 cells - Host mRNA CCNB2 http://www.ncbi.nlm.nih.gov/gene/9133 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011501 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30d(miR-30d) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000255 A549 cells - Host mRNA CDCA8 http://www.ncbi.nlm.nih.gov/gene/55143 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011502 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30d(miR-30d) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000255 A549 cells - Host mRNA DEPDC1B http://www.ncbi.nlm.nih.gov/gene/55789 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011503 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30d(miR-30d) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000255 A549 cells - Host mRNA INCENP http://www.ncbi.nlm.nih.gov/gene/3619 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011504 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30d(miR-30d) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000255 A549 cells - Host mRNA KIF11 http://www.ncbi.nlm.nih.gov/gene/3832 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011505 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30d(miR-30d) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000255 A549 cells - Host mRNA RAD23B http://www.ncbi.nlm.nih.gov/gene/5887 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011506 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30d(miR-30d) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000255 A549 cells - Host mRNA SLC6A6 http://www.ncbi.nlm.nih.gov/gene/6533 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011507 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-30d(miR-30d) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000255 A549 cells - Host mRNA ZCCHC16(MAR4) http://www.ncbi.nlm.nih.gov/gene/340595 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011508 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-31(miR-31) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000089 Peripheral blood mononuclear cells - Host Protein MAPK11 http://www.ncbi.nlm.nih.gov/gene/5600 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients. HHID00011509 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-31(miR-31) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000089 Peripheral blood mononuclear cells - Host Protein MAPK13 http://www.ncbi.nlm.nih.gov/gene/5603 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients. HHID00011510 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-31(miR-31) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000089 Peripheral blood mononuclear cells - Host Protein MAPK14 http://www.ncbi.nlm.nih.gov/gene/1432 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients. HHID00011511 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-31(miR-31) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000089 Peripheral blood mononuclear cells - Host mRNA FOXP3 http://www.ncbi.nlm.nih.gov/gene/50943 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 Our miRNA microarray and RT-PCR analysis revealed that miR-31 was significantly down-expressed in PBMCs of H1N1 critically ill patients.MiR-31 can negatively regulate FOXP3 expression by binding directly to its potential target site in the 3'UTR of FOXP3 mRNA. HHID00011512 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-342(miR-342) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000805 Peripheral blood mononuclear cells Downregulation Host Protein EGFR http://www.ncbi.nlm.nih.gov/gene/1956 Upregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 We found that EGFR was regulated by miR-342, miR-155, miR-30b, miR-210, miR-192, let-7g, and miR-146b-5p, which were all down expressed in H1N1 critically ill patients.These downregulated miRNAs can upregulate EGFR expression, resulting in easier virus replication and propagation at the early stage of infection. . HHID00011513 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-342(miR-342-3p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000805 Peripheral blood mononuclear cells Downregulation Host Protein CASP3(caspase-3) http://www.ncbi.nlm.nih.gov/gene/836 Upregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 In our study, CASP3 was significantly upregulated by qRT-PCR analysis(Figure 6) and targeted by the downregulated miRNAs: miR-342-3p, miR-29b, miR-29c, miR-29a, let-7g and miR-30b, which can be expected to develop miRNA-based therapeutics for influenza disease. HHID00011514 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-342-3p(miR-342-3p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000805 Peripheral blood mononuclear cells Downregulation Host mRNA Mx1 http://www.ncbi.nlm.nih.gov/gene/4599 Downregulation Predicted. 23731466 In our study, we found that Mx1 mRNA was significantly upregulated in H1N1 critically ill patients by qRT-PCR assay. No validated miRNA targeting Mx1 has been reported; thus,Our miRNA target prediction result indicated that Mx1 can be negatively regulated by miR-342-3p and miR-210, which were both down expressed in H1N1 critically ill patient. HHID00011515 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-361(miR-361-3p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000760 Peripheral blood mononuclear cells - Host Protein MAPK13 http://www.ncbi.nlm.nih.gov/gene/5603 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients. HHID00011516 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-361(miR-361-3p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000760 Peripheral blood mononuclear cells - Host Protein MAPK14 http://www.ncbi.nlm.nih.gov/gene/1432 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients. HHID00011517 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-361-3p(miR-361-3p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000760 Peripheral blood mononuclear cells - Host Protein MAPK11 http://www.ncbi.nlm.nih.gov/gene/5600 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients. HHID00011518 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-362(miR-362-3p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000762 Peripheral blood mononuclear cells - Host Protein MAPK13 http://www.ncbi.nlm.nih.gov/gene/5603 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients. HHID00011519 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-362(miR-362-3p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000762 Peripheral blood mononuclear cells - Host Protein MAPK14 http://www.ncbi.nlm.nih.gov/gene/1432 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients. HHID00011520 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-362-3p(miR-362-3p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000762 Peripheral blood mononuclear cells - Host Protein MAPK11 http://www.ncbi.nlm.nih.gov/gene/5600 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients. HHID00011521 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-451a(miR-451) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001729 - Upregulation Host Protein CCL3 http://www.ncbi.nlm.nih.gov/gene/6348 - RT-PCR. 23169590 We used quantitative RT-PCR to confirm that miR-451 is increased following influenza infection for 8 hours. miR-451 regulates dendritic cell cytokine responses to influenza infection. Inhibition of miR-451 expression correlated with increased YWHAZ protein expression and decreased ZFP36 expression, providing a possible mechanism for the elevated secretion of IL-6, TNF, CCL5/RANTES, and CCL3/MIP1 alpha. HHID00011522 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-451a(miR-451) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001729 - Upregulation Host Protein CCL5 http://www.ncbi.nlm.nih.gov/gene/6352 - RT-PCR. 23169590 We used quantitative RT-PCR to confirm that miR-451 is increased following influenza infection for 8 hours. miR-451 regulates dendritic cell cytokine responses to influenza infection. Inhibition of miR-451 expression correlated with increased YWHAZ protein expression and decreased ZFP36 expression, providing a possible mechanism for the elevated secretion of IL-6, TNF, CCL5/RANTES, and CCL3/MIP1 alpha. HHID00011523 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-451a(miR-451) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001729 - Upregulation Host Protein IL-6 http://www.ncbi.nlm.nih.gov/gene/3569 - RT-PCR. 23169590 We used quantitative RT-PCR to confirm that miR-451 is increased following influenza infection for 8 hours. miR-451 regulates dendritic cell cytokine responses to influenza infection. Inhibition of miR-451 expression correlated with increased YWHAZ protein expression and decreased ZFP36 expression, providing a possible mechanism for the elevated secretion of IL-6, TNF, CCL5/RANTES, and CCL3/MIP1 alpha. HHID00011524 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-451a(miR-451) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001729 - Upregulation Host Protein YWHAZ http://www.ncbi.nlm.nih.gov/gene/7534 Downregulation RT-PCR. 23169590 We used quantitative RT-PCR to confirm that miR-451 is increased following influenza infection for 8 hours. miR-451 regulates dendritic cell cytokine responses to influenza infection. Inhibition of miR-451 expression correlated with increased YWHAZ protein expression and decreased ZFP36 expression, providing a possible mechanism for the elevated secretion of IL-6, TNF, CCL5/RANTES, and CCL3/MIP1 alpha. HHID00011525 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-451a(miR-451) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001729 - Upregulation Host Protein ZFP36 http://www.ncbi.nlm.nih.gov/gene/7538 Upregulation RT-PCR. 23169590 We used quantitative RT-PCR to confirm that miR-451 is increased following influenza infection for 8 hours. miR-451 regulates dendritic cell cytokine responses to influenza infection. Inhibition of miR-451 expression correlated with increased YWHAZ protein expression and decreased ZFP36 expression, providing a possible mechanism for the elevated secretion of IL-6, TNF, CCL5/RANTES, and CCL3/MIP1 alpha. HHID00011526 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA ABCG1 http://www.ncbi.nlm.nih.gov/gene/9619 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011527 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA AGTR1 http://www.ncbi.nlm.nih.gov/gene/185 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011528 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA ANGPTL4 http://www.ncbi.nlm.nih.gov/gene/51129 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011529 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA ANXA13 http://www.ncbi.nlm.nih.gov/gene/312 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011530 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA CA9 http://www.ncbi.nlm.nih.gov/gene/768 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011531 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA CAPN12 http://www.ncbi.nlm.nih.gov/gene/147968 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011532 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA CPS1 http://www.ncbi.nlm.nih.gov/gene/1373 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011533 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA CRELD1 http://www.ncbi.nlm.nih.gov/gene/78987 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011534 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA FCGBP http://www.ncbi.nlm.nih.gov/gene/8857 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011535 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA FGA http://www.ncbi.nlm.nih.gov/gene/2243 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011536 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA FGB http://www.ncbi.nlm.nih.gov/gene/2244 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011537 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA FGL1 http://www.ncbi.nlm.nih.gov/gene/2267 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011538 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA FILIP1 http://www.ncbi.nlm.nih.gov/gene/27145 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011539 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA FLJ31568 - - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011540 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA FOS http://www.ncbi.nlm.nih.gov/gene/2353 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011541 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA ITGA2 http://www.ncbi.nlm.nih.gov/gene/3673 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011542 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA KLF2 http://www.ncbi.nlm.nih.gov/gene/10365 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011543 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA LRP5 http://www.ncbi.nlm.nih.gov/gene/4041 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011544 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA MAOA http://www.ncbi.nlm.nih.gov/gene/4128 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011545 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA MTUS1 http://www.ncbi.nlm.nih.gov/gene/57509 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011546 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA NCALD http://www.ncbi.nlm.nih.gov/gene/83988 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011547 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA OCEL1 http://www.ncbi.nlm.nih.gov/gene/79629 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011548 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA PDE7B http://www.ncbi.nlm.nih.gov/gene/27115 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011549 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA RAB4B http://www.ncbi.nlm.nih.gov/gene/53916 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011550 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA RHOB http://www.ncbi.nlm.nih.gov/gene/388 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011551 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA SCARA5 http://www.ncbi.nlm.nih.gov/gene/286133 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011552 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA SH3PXD2A http://www.ncbi.nlm.nih.gov/gene/9644 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011553 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA SLC29A4 http://www.ncbi.nlm.nih.gov/gene/222962 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011554 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA SLP1 http://www.ncbi.nlm.nih.gov/gene/9399 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011555 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA SMOC1 http://www.ncbi.nlm.nih.gov/gene/64093 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011556 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA STEAP2 http://www.ncbi.nlm.nih.gov/gene/261729 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011557 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA TCN1 http://www.ncbi.nlm.nih.gov/gene/6947 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011558 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA TM7SF2 http://www.ncbi.nlm.nih.gov/gene/7108 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011559 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA TRIM9 http://www.ncbi.nlm.nih.gov/gene/114088 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011560 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA TSC22D3 http://www.ncbi.nlm.nih.gov/gene/1831 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011561 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-766 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003836 A549 cells - Host mRNA TTLL6 http://www.ncbi.nlm.nih.gov/gene/284076 - Predicted. 22438559 Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1. Fig 3 The network displays predicted interactions between deregulated miRNAs and deregulated mRNAs from two microarray experiments and were generated using a fold-change cutoff ±2, P <0.05, miRanda target prediction, GenMiR++ scoring, and negative-correlation filtering. Red indicates upregulated miRNAs and mRNAs, while blue indicates downregulation. HHID00011562 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-769(miR-769-5p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003834 Peripheral blood mononuclear cells - Host Protein MAPK11 http://www.ncbi.nlm.nih.gov/gene/5600 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients. HHID00011563 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-769(miR-769-5p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003834 Peripheral blood mononuclear cells - Host Protein MAPK13 http://www.ncbi.nlm.nih.gov/gene/5603 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients. HHID00011564 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-769(miR-769-5p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003834 Peripheral blood mononuclear cells - Host Protein MAPK14 http://www.ncbi.nlm.nih.gov/gene/1432 Downregulation RNA isolation and quality control,MiRNA expression profiling,Microarray data submission,QRT-PCR,Receiver operating characteristic (ROC) analysis,MiRNA target prediction,Protein-protein interaction,Enrichment analysis and network construction. 23731466 P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients. HHID00011565 Influenza A virus H1N1(H1N1) Mus musculus Host miRNA mmu-let-7g(let-7g) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000137 A549 cells and primary cultured T cells - Host Protein Interleukin 13(IL-13) http://www.ncbi.nlm.nih.gov/gene/3596 Downregulation In silico identification of microRNA binding sites,Cell culture and transfection,Cell culture and transfection,RNA extraction and RT-PCR,RNA extraction and RT-PCR,RNA extraction and RT-PCR,Development of the ovalbumin-sensitized murine model of asthma and treatment of mice with let-7,MicroRNA design and delivery,Measurement of AHR,Measurement of cytokine (IL-4, IL-5, IL-13, and IFN-γ) levels in culture supernatant and lung homogenate and estimation of differential count in bronchoalveolar lavage fluid,Lung histology,Statistical analysis. 23731466 Moreover,let-7g could inhibit the expression of IL-13, a key inducer of airway inflammation secreted by TH2 lymphocytes and other cells. HHID00011566 Influenza A virus H1N1(H1N1) Mus musculus Host miRNA mmu-mir-29a(miR-29a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000576 CD4+ T cells Downregulation Host Protein Tbx21(T-bet) http://www.ncbi.nlm.nih.gov/gene/57765 Downregulation T Cell Stimulation and Transfection,miRNA Screening and Analysis,Adoptive Transfer and LCMV Infection,Microarray Procedures and Analysis,Luciferase Reporter Assays. 23731466 Both miR-29a and miR-29b could repress IFN-gamma production by direct targeting of both T-box transcription factor T-bet and Eomesodermin(Eomes), two transcription factors known to induce IFN-gamma production. HHID00011567 Influenza A virus H1N1(H1N1) Mus musculus Host miRNA mmu-mir-29b-1(miR-29b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000143 CD4+ T cells Downregulation Host Protein Eomes http://www.ncbi.nlm.nih.gov/gene/13813 Downregulation T Cell Stimulation and Transfection,miRNA Screening and Analysis,Adoptive Transfer and LCMV Infection,Microarray Procedures and Analysis,Luciferase Reporter Assays. 23731466 Both miR-29a and miR-29b could repress IFN-gamma production by direct targeting of both T-box transcription factor T-bet and Eomesodermin(Eomes), two transcription factors known to induce IFN-gamma production. HHID00011568 Influenza A virus H3N2(H3N2) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein ABL2 http://www.ncbi.nlm.nih.gov/gene/27 Downregulation RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011569 Influenza A virus H3N2(H3N2) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein BCL11A http://www.ncbi.nlm.nih.gov/gene/53335 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011570 Influenza A virus H3N2(H3N2) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein BCORL1 http://www.ncbi.nlm.nih.gov/gene/63035 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011571 Influenza A virus H3N2(H3N2) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein CARD10 http://www.ncbi.nlm.nih.gov/gene/29775 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011572 Influenza A virus H3N2(H3N2) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein DNPEP http://www.ncbi.nlm.nih.gov/gene/23549 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011573 Influenza A virus H3N2(H3N2) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein FLOT2 http://www.ncbi.nlm.nih.gov/gene/2319 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011574 Influenza A virus H3N2(H3N2) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein GALNT10 http://www.ncbi.nlm.nih.gov/gene/55568 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011575 Influenza A virus H3N2(H3N2) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein IRAK1(IRAK-1) http://www.ncbi.nlm.nih.gov/gene/3654 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011576 Influenza A virus H3N2(H3N2) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein KBTBD3 http://www.ncbi.nlm.nih.gov/gene/143879 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011577 Influenza A virus H3N2(H3N2) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein KDM6B(JMJD3) http://www.ncbi.nlm.nih.gov/gene/23135 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011578 Influenza A virus H3N2(H3N2) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein LFNG http://www.ncbi.nlm.nih.gov/gene/3955 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011579 Influenza A virus H3N2(H3N2) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein SLC2A3 http://www.ncbi.nlm.nih.gov/gene/6515 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011580 Influenza A virus H3N2(H3N2) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein STRA13 http://www.ncbi.nlm.nih.gov/gene/201254 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011581 Influenza A virus H3N2(H3N2) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein STRBP http://www.ncbi.nlm.nih.gov/gene/55342 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011582 Influenza A virus H3N2(H3N2) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein SYT1 http://www.ncbi.nlm.nih.gov/gene/6857 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011583 Influenza A virus H3N2(H3N2) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung epithelial cells Upregulation Host Protein ZNF532 http://www.ncbi.nlm.nih.gov/gene/55205 RT-qPCR. 23343627 In this study, we performed miRNA global profiling in human lung epithelial cells(A549) infected by two different subtypes of human influenza A viruses(H1N1 and H3N2). Among the five miRNA hits, the only upregulated miRNA in response to influenza infection corresponded to miR-146a.Table 1. Gene expression data for the 16 miR-146a target genes down-modulated after influenza infection. HHID00011584 Influenza A virus H5N1(H5N1) Homo sapiens Host miRNA hsa-mir-141(miR-141) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000457 Epithelial cells Upregulation Host Protein TGFB2(TGF-beta2) http://www.ncbi.nlm.nih.gov/gene/7042 Downregulation Enzyme-linked immunosorbent assay (ELISA), qRT-PCR, gene expression profiles. 23663545 Interestingly,we demonstrated that miR-141, which was more highly induced by H5N1 than by H1N1(p < 0.05), had an ability to suppress the expression of a cytokine - transforming growth factor(TGF)-beta2.Since TGF-beta2 is an important cytokine that can act as both an immunosuppressive agent and a potent proinflammatory molecule through its ability to attract and regulate inflammatory molecules, and previous report showed that only seasonal influenza H1N1(but not the other avian influenza subtypes) could induce a persistent expression of TGF-beta2, we speculate that the modulation of TGF-beta2 expression by different influenza subtypes via miR-141 might be a critical step for determining the outcome of either normal or excessive inflammation progression. HHID00011585 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-1275(miR-1275) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006415 Lung cell lines - Host mRNA AK3 http://www.ncbi.nlm.nih.gov/gene/50808 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011586 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-1275(miR-1275) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006415 Lung cell lines - Host mRNA CALU http://www.ncbi.nlm.nih.gov/gene/813 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011587 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-1275(miR-1275) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006415 Lung cell lines - Host mRNA DCBLD2 http://www.ncbi.nlm.nih.gov/gene/131566 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011588 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-1275(miR-1275) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006415 Lung cell lines - Host mRNA DPYSL3 http://www.ncbi.nlm.nih.gov/gene/1809 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011589 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-1275(miR-1275) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006415 Lung cell lines - Host mRNA ESYT2 http://www.ncbi.nlm.nih.gov/gene/57488 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011590 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-1275(miR-1275) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006415 Lung cell lines - Host mRNA IRAK1 http://www.ncbi.nlm.nih.gov/gene/3654 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011591 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-1275(miR-1275) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006415 Lung cell lines - Host mRNA MAPK3 http://www.ncbi.nlm.nih.gov/gene/5595 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011592 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-1275(miR-1275) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006415 Lung cell lines - Host mRNA PPP1R14B http://www.ncbi.nlm.nih.gov/gene/26472 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011593 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-132(miR-132) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000449 Lung cell lines - Host mRNA AK3 http://www.ncbi.nlm.nih.gov/gene/50808 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011594 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-132(miR-132) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000449 Lung cell lines - Host mRNA BRI3 http://www.ncbi.nlm.nih.gov/gene/25798 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011595 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-132(miR-132) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000449 Lung cell lines - Host mRNA CALU http://www.ncbi.nlm.nih.gov/gene/813 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011596 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-132(miR-132) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000449 Lung cell lines - Host mRNA DAZAP2 http://www.ncbi.nlm.nih.gov/gene/9802 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011597 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-132(miR-132) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000449 Lung cell lines - Host mRNA DCBLD2 http://www.ncbi.nlm.nih.gov/gene/131566 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011598 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-132(miR-132) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000449 Lung cell lines - Host mRNA DPY19L1 http://www.ncbi.nlm.nih.gov/gene/23333 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011599 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-132(miR-132) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000449 Lung cell lines - Host mRNA DPYSL3 http://www.ncbi.nlm.nih.gov/gene/1809 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011600 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-132(miR-132) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000449 Lung cell lines - Host mRNA EIF2S3 http://www.ncbi.nlm.nih.gov/gene/1968 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011601 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-132(miR-132) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000449 Lung cell lines - Host mRNA ESYT2 http://www.ncbi.nlm.nih.gov/gene/57488 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011602 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-132(miR-132) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000449 Lung cell lines - Host mRNA MAPK3 http://www.ncbi.nlm.nih.gov/gene/5595 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011603 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-132(miR-132) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000449 Lung cell lines - Host mRNA MMGT1 http://www.ncbi.nlm.nih.gov/gene/93380 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011604 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-132(miR-132) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000449 Lung cell lines - Host mRNA NAP1L1 http://www.ncbi.nlm.nih.gov/gene/4673 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011605 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-132(miR-132) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000449 Lung cell lines - Host mRNA NDUFB10 http://www.ncbi.nlm.nih.gov/gene/4716 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011606 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-132(miR-132) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000449 Lung cell lines - Host mRNA PAIP2 http://www.ncbi.nlm.nih.gov/gene/51247 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011607 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-132(miR-132) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000449 Lung cell lines - Host mRNA SDF2 http://www.ncbi.nlm.nih.gov/gene/6388 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011608 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-132(miR-132) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000449 Lung cell lines - Host mRNA STMN1 http://www.ncbi.nlm.nih.gov/gene/3925 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011609 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-132(miR-132) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000449 Lung cell lines - Host mRNA TMEM136 http://www.ncbi.nlm.nih.gov/gene/219902 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011610 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-132(miR-132) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000449 Lung cell lines - Host mRNA TSPAN6 http://www.ncbi.nlm.nih.gov/gene/7105 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011611 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-132(miR-132) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000449 Lung cell lines - Host mRNA YWHAG http://www.ncbi.nlm.nih.gov/gene/7532 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011612 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-146a(miR-146) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung cell lines - Host mRNA IRAK1 http://www.ncbi.nlm.nih.gov/gene/3654 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011613 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung cell lines - Host mRNA CALU http://www.ncbi.nlm.nih.gov/gene/813 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011614 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung cell lines - Host mRNA COPS8 http://www.ncbi.nlm.nih.gov/gene/10920 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011615 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung cell lines - Host mRNA ESYT2 http://www.ncbi.nlm.nih.gov/gene/57488 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011616 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung cell lines - Host mRNA TIMM17B http://www.ncbi.nlm.nih.gov/gene/10245 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011617 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung cell lines - Host mRNA TMEM136 http://www.ncbi.nlm.nih.gov/gene/219902 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011618 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Lung cell lines - Host mRNA TOR1A http://www.ncbi.nlm.nih.gov/gene/1861 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011619 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-187(miR-187) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000274 Lung cell lines - Host mRNA TMEM136 http://www.ncbi.nlm.nih.gov/gene/219902 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011620 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-200c(miR-200c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000650 Lung cell lines - Host mRNA CALU http://www.ncbi.nlm.nih.gov/gene/813 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011621 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-200c(miR-200c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000650 Lung cell lines - Host mRNA COPS8 http://www.ncbi.nlm.nih.gov/gene/10920 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011622 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-200c(miR-200c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000650 Lung cell lines - Host mRNA DCBLD2 http://www.ncbi.nlm.nih.gov/gene/131566 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011623 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-200c(miR-200c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000650 Lung cell lines - Host mRNA DPY19L1 http://www.ncbi.nlm.nih.gov/gene/23333 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011624 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-200c(miR-200c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000650 Lung cell lines - Host mRNA ESYT2 http://www.ncbi.nlm.nih.gov/gene/57488 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011625 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-200c(miR-200c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000650 Lung cell lines - Host mRNA MMGT1 http://www.ncbi.nlm.nih.gov/gene/93380 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011626 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-200c(miR-200c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000650 Lung cell lines - Host mRNA NAP1L1 http://www.ncbi.nlm.nih.gov/gene/4673 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011627 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-200c(miR-200c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000650 Lung cell lines - Host mRNA PAIP2 http://www.ncbi.nlm.nih.gov/gene/51247 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011628 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-200c(miR-200c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000650 Lung cell lines - Host mRNA YWHAG http://www.ncbi.nlm.nih.gov/gene/7532 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011629 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-29c(miR-29c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000735 A549 cells Upregulation Host mRNA BCL2L2 http://www.ncbi.nlm.nih.gov/gene/599 - Predicted. 22850539 In silico target prediction analysis revealed complementarity of miR-29c to the 3'-untranslated region (UTR) of BCL2L2 mRNA. Targeting of BCL2L2 3' UTR by miR-29c was determined by luciferase assay. HHID00011630 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-7(miR-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000263 Lung cell lines - Host mRNA AK3 http://www.ncbi.nlm.nih.gov/gene/50808 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011631 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-7(miR-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000263 Lung cell lines - Host mRNA CALU http://www.ncbi.nlm.nih.gov/gene/813 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011632 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-7(miR-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000263 Lung cell lines - Host mRNA DAZAP2 http://www.ncbi.nlm.nih.gov/gene/9802 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011633 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-7(miR-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000263 Lung cell lines - Host mRNA DCBLD2 http://www.ncbi.nlm.nih.gov/gene/131566 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011634 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-7(miR-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000263 Lung cell lines - Host mRNA DPYSL3 http://www.ncbi.nlm.nih.gov/gene/1809 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011635 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-7(miR-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000263 Lung cell lines - Host mRNA EIF2S3 http://www.ncbi.nlm.nih.gov/gene/1968 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011636 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-7(miR-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000263 Lung cell lines - Host mRNA MTPN http://www.ncbi.nlm.nih.gov/gene/136319 Downregulation Reverse Transcription, Real-time PCR, Immunoblotting, RNA Purification, Indirect Immunofluorescence, MicroRNA Microarray Analysis, Gene Expression Profiling and Pathway Analysis, and miRNA Analysis. 22822053 Table2 Abundance ofmiRNA targetedmRNAs during influenza A virus infection. However, data analysis identi-fied 36 genes that were differentially expressed during infection in the presence of miRNA mimics: decreased expression was Observed for 26 genes, whereas 10 genes increased expression (greater than 1.5-fold threshold, see Table 2).Examination of miRNA abundance in human lung cell lines revealed endogenous miRNAs, including miR-7, miR-132, miR-146a, miR-187, miR-200c, and miR-1275.Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems. HHID00011637 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA has-mir-608(hsa-miR-608) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003621 HEK293 and HeLa cells - Host Protein IL6(hIL6) http://www.ncbi.nlm.nih.gov/gene/3569 Downregulation Immunohistochemistry and Immunofluorescence, qRT-PCR, Transient cotransfection, ELISA, Western blot analysis, RNA-protein pulldown assay, In vitro transcription/translation assay, In situ hybridization. 21984125 We show a direct repression of vIL6 by hsa-miR-1293 and hIL6 by hsa-miR-608. The repression of vIL6 by miR-1293 was reversed by disruption of the vIL6 miR-1293 seed match through the introduction of point mutations. In addition, expression of vIL6 or hIL6 in KSHV-infected cells could be enhanced by transfection of the respective miRNA inhibitors. HHID00011638 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Human Umbilical Vein Endothelial Cells Upregulation Host Protein CXCR4 http://www.ncbi.nlm.nih.gov/gene/7852 Downregulation Statistical Analysis, Luciferase Reporter Assay, Quantitative Real-time PCR. 20023696 Kaposi's sarcoma(KS)-associated herpesvirus(KSHV)-encoded viral FLICE inhibitory protein(vFLIP) K13 is a potent activator of the nuclear factor-kappaB(NF-kappaB) pathway. Our results show that K13-induced NF-kappaB activity suppresses CXCR4 through upregulation of miR-146a. HHID00011639 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 - - Host Protein AGTRAP http://www.ncbi.nlm.nih.gov/gene/57085 - Predicted. 18075594 Suppl. Table 3.List of shared targets for miR-K12-11 and miR-155 validated in this study.The remaining genes were included based on our microarray analysis of miR-K12-11 expressing BJAB cells. HHID00011640 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 - - Host Protein HIVEP2 http://www.ncbi.nlm.nih.gov/gene/3097 - Predicted. 18075594 Suppl. Table 3.List of shared targets for miR-K12-11 and miR-155 validated in this study.The remaining genes were included based on our microarray analysis of miR-K12-11 expressing BJAB cells. HHID00011641 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 - - Host Protein IKBKE http://www.ncbi.nlm.nih.gov/gene/9641 - Predicted. 18075594 Suppl. Table 3.List of shared targets for miR-K12-11 and miR-155 validated in this study.BACH1, IKBKE,MAP3K10, MLSTD2 and RPS6KA3 were included because they are predicted targets for miR-155. HHID00011642 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 - - Host Protein MAP3K10 http://www.ncbi.nlm.nih.gov/gene/4294 - Predicted. 18075594 Suppl. Table 3.List of shared targets for miR-K12-11 and miR-155 validated in this study.The remaining genes were included based on our microarray analysis of miR-K12-11 expressing BJAB cells. HHID00011643 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 - - Host Protein MLSTD2 http://www.ncbi.nlm.nih.gov/gene/84188 - Predicted. 18075594 Suppl. Table 3.List of shared targets for miR-K12-11 and miR-155 validated in this study.The remaining genes were included based on our microarray analysis of miR-K12-11 expressing BJAB cells. HHID00011644 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 - - Host Protein PIK3CA http://www.ncbi.nlm.nih.gov/gene/5290 - Predicted. 18075594 Suppl. Table 3.List of shared targets for miR-K12-11 and miR-155 validated in this study.The remaining genes were included based on our microarray analysis of miR-K12-11 expressing BJAB cells. HHID00011645 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 - - Host Protein RFK http://www.ncbi.nlm.nih.gov/gene/55312 - Predicted. 18075594 Suppl. Table 3.List of shared targets for miR-K12-11 and miR-155 validated in this study.The remaining genes were included based on our microarray analysis of miR-K12-11 expressing BJAB cells. HHID00011646 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 - - Host Protein RPS6KA3 http://www.ncbi.nlm.nih.gov/gene/6197 - Predicted. 18075594 Suppl. Table 3.List of shared targets for miR-K12-11 and miR-155 validated in this study.BACH1, IKBKE,MAP3K10, MLSTD2 and RPS6KA3 were included because they are predicted targets for miR-155. HHID00011647 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 - - Host Protein SAMHD1 http://www.ncbi.nlm.nih.gov/gene/25939 - Predicted. 18075594 Suppl. Table 3.List of shared targets for miR-K12-11 and miR-155 validated in this study.The remaining genes were included based on our microarray analysis of miR-K12-11 expressing BJAB cells. HHID00011648 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 - - Host Protein SLA http://www.ncbi.nlm.nih.gov/gene/6503 - Predicted. 18075594 Suppl. Table 3.List of shared targets for miR-K12-11 and miR-155 validated in this study.Of these, HIVEP2 and SLA are also predicted targets for miR-155. HHID00011649 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 - - Host Protein TWF1 http://www.ncbi.nlm.nih.gov/gene/5756 - Predicted. 18075594 Suppl. Table 3.List of shared targets for miR-K12-11 and miR-155 validated in this study.The remaining genes were included based on our microarray analysis of miR-K12-11 expressing BJAB cells. HHID00011650 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 - - Host Protein XAF1(BIRC4BP) http://www.ncbi.nlm.nih.gov/gene/54739 - Predicted. 18075594 Suppl. Table 3.List of shared targets for miR-K12-11 and miR-155 validated in this study.The remaining genes were included based on our microarray analysis of miR-K12-11 expressing BJAB cells. HHID00011651 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 B-cell - Host mRNA BRIP1(BACH-1) http://www.ncbi.nlm.nih.gov/gene/83990 Downregulation Luciferase assays,Northern blot analysis,Microarray. 17881434 Bioinformatic tools predicted the transcriptional repressor BACH-1 to be targeted by both miRNAs, and ectopic expression of either miR-155 or miR-K12-11 inhibited a BACH-1 3'UTR-containing reporter. Furthermore, BACH-1 protein levels are low in cells expressing either miRNA.Kaposi's sarcoma-associated herpesvirus (KSHV), a virus linked to malignancies including primary effusion lymphoma (PEL), encodes 12 miRNA genes, but only a few regulatory targets are known. We found that KSHV-miR-K12-11 shares 100% seed sequence homology with hsa-miR-155. HHID00011652 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BCP-1,BC-1,VG-1,JSC-1,RAJI,BCBL-1,and BJAB cell lines - Host Protein LDOC1 http://www.ncbi.nlm.nih.gov/gene/23641 Downregulation RNA extraction for RT-PCR, Affymetrix array-based gene expression profiling, Cell lines and transfections, Northern blot analysis, Immunoblotting, Luciferase assays. 17881434 We observed a significant inhibition of luciferase from reporters containing the 3'UTRs of LDOC1, MATR3, and TM6SF1 in the presence of miR-155 or miR-K12-11. In contrast, neither miRNA had any effect on the PHF17 or NFAT2CIP 3'UTRs.Thus, these assays confirmed LDOC1, MATR3, and TM6SF1 as being targets of both miR-155 and miR-K12-11. HHID00011653 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BCP-1,BC-1,VG-1,JSC-1,RAJI,BCBL-1,and BJAB cell lines - Host Protein MATR3 http://www.ncbi.nlm.nih.gov/gene/9782 Downregulation RNA extraction for RT-PCR, Affymetrix array-based gene expression profiling, Cell lines and transfections, Northern blot analysis, Immunoblotting, Luciferase assays. 17881434 We observed a significant inhibition of luciferase from reporters containing the 3'UTRs of LDOC1, MATR3, and TM6SF1 in the presence of miR-155 or miR-K12-11. In contrast, neither miRNA had any effect on the PHF17 or NFAT2CIP 3'UTRs.Thus, these assays confirmed LDOC1, MATR3, and TM6SF1 as being targets of both miR-155 and miR-K12-11. HHID00011654 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BCP-1,BC-1,VG-1,JSC-1,RAJI,BCBL-1,and BJAB cell lines - Host Protein TM6SF1 http://www.ncbi.nlm.nih.gov/gene/53346 Downregulation RNA extraction for RT-PCR, Affymetrix array-based gene expression profiling, Cell lines and transfections, Northern blot analysis, Immunoblotting, Luciferase assays. 17881434 We observed a significant inhibition of luciferase from reporters containing the 3'UTRs of LDOC1, MATR3, and TM6SF1 in the presence of miR-155 or miR-K12-11. In contrast, neither miRNA had any effect on the PHF17 or NFAT2CIP 3'UTRs. Thus, these assays confirmed LDOC1, MATR3, and TM6SF1 as being targets of both miR-155 and miR-K12-11. HHID00011655 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein ABHD6(NA) http://www.ncbi.nlm.nih.gov/gene/57406 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011656 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein AGTRAP http://www.ncbi.nlm.nih.gov/gene/57085 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011657 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein AMOTL1 http://www.ncbi.nlm.nih.gov/gene/154810 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011658 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein ARHGAP21 http://www.ncbi.nlm.nih.gov/gene/57584 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011659 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein ARRDC2 http://www.ncbi.nlm.nih.gov/gene/27106 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011660 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein ATP6V1G1 http://www.ncbi.nlm.nih.gov/gene/9550 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011661 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein BMI1 http://www.ncbi.nlm.nih.gov/gene/648 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011662 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein C10orf35 http://www.ncbi.nlm.nih.gov/gene/219738 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011663 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein C9orf116 http://www.ncbi.nlm.nih.gov/gene/138162 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011664 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein C9orf78 http://www.ncbi.nlm.nih.gov/gene/51759 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011665 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein CARD6 http://www.ncbi.nlm.nih.gov/gene/84674 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011666 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein CDC42EP3 http://www.ncbi.nlm.nih.gov/gene/10602 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011667 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein CSNK1G2 http://www.ncbi.nlm.nih.gov/gene/1455 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011668 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein CSNK1G2(NA) http://www.ncbi.nlm.nih.gov/gene/1455 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011669 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein DCAMKL1 http://www.ncbi.nlm.nih.gov/gene/9201 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011670 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein DPY19L1 http://www.ncbi.nlm.nih.gov/gene/23333 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011671 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein E2F3 http://www.ncbi.nlm.nih.gov/gene/1871 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011672 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein ERMAP http://www.ncbi.nlm.nih.gov/gene/114625 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011673 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein FAM70A http://www.ncbi.nlm.nih.gov/gene/55026 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011674 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein FBXO33(NA) http://www.ncbi.nlm.nih.gov/gene/254170 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011675 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein FOS http://www.ncbi.nlm.nih.gov/gene/2353 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011676 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein GALT http://www.ncbi.nlm.nih.gov/gene/2592 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011677 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein GBA2 http://www.ncbi.nlm.nih.gov/gene/57704 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011678 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein GPSM2 http://www.ncbi.nlm.nih.gov/gene/29899 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011679 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein HIVEP2 http://www.ncbi.nlm.nih.gov/gene/3097 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011680 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein HMGCS1 http://www.ncbi.nlm.nih.gov/gene/3157 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011681 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein HSPA5 http://www.ncbi.nlm.nih.gov/gene/3309 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011682 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein IKIP http://www.ncbi.nlm.nih.gov/gene/121457 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011683 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein KIAA0408(NA) http://www.ncbi.nlm.nih.gov/gene/9729 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011684 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein MADH6 http://www.ncbi.nlm.nih.gov/gene/4091 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011685 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein MGC13057 http://www.ncbi.nlm.nih.gov/gene/84281 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011686 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein MRGPRF http://www.ncbi.nlm.nih.gov/gene/219928 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011687 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein MUC20 http://www.ncbi.nlm.nih.gov/gene/200958 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011688 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein MYB http://www.ncbi.nlm.nih.gov/gene/4602 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011689 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein MYO1D http://www.ncbi.nlm.nih.gov/gene/4642 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011690 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein PICALM http://www.ncbi.nlm.nih.gov/gene/8301 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011691 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein PIK3CA http://www.ncbi.nlm.nih.gov/gene/5290 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011692 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein PITPNM2 http://www.ncbi.nlm.nih.gov/gene/57605 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011693 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein PLEKHA5 http://www.ncbi.nlm.nih.gov/gene/54477 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011694 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein PLEKHB2 http://www.ncbi.nlm.nih.gov/gene/55041 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011695 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein POLE3 http://www.ncbi.nlm.nih.gov/gene/54107 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011696 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein PRPF4B(NA) http://www.ncbi.nlm.nih.gov/gene/8899 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011697 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein PTDSS1 http://www.ncbi.nlm.nih.gov/gene/9791 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011698 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein RFK http://www.ncbi.nlm.nih.gov/gene/55312 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011699 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein RIPK5 http://www.ncbi.nlm.nih.gov/gene/25778 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011700 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein RNF123 http://www.ncbi.nlm.nih.gov/gene/63891 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011701 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein RNF166 http://www.ncbi.nlm.nih.gov/gene/115992 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011702 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein RNF213(NA) http://www.ncbi.nlm.nih.gov/gene/57674 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011703 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein RNF31 http://www.ncbi.nlm.nih.gov/gene/55072 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011704 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein RXRA http://www.ncbi.nlm.nih.gov/gene/6256 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011705 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein SAMHD1 http://www.ncbi.nlm.nih.gov/gene/25939 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011706 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein SCAMP1 http://www.ncbi.nlm.nih.gov/gene/9522 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011707 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein SEC13 http://www.ncbi.nlm.nih.gov/gene/6396 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011708 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein SGK http://www.ncbi.nlm.nih.gov/gene/6446 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011709 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein SGPL1 http://www.ncbi.nlm.nih.gov/gene/8879 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011710 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein SLA http://www.ncbi.nlm.nih.gov/gene/6503 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011711 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein SLC33A1 http://www.ncbi.nlm.nih.gov/gene/9197 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011712 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein TAF12 http://www.ncbi.nlm.nih.gov/gene/6883 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011713 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein TLE4 http://www.ncbi.nlm.nih.gov/gene/7091 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011714 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein TRIP13 http://www.ncbi.nlm.nih.gov/gene/9319 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011715 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein TWF1 http://www.ncbi.nlm.nih.gov/gene/5756 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011716 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein USP8 http://www.ncbi.nlm.nih.gov/gene/9101 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011717 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein WEE1 http://www.ncbi.nlm.nih.gov/gene/7465 Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011718 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 BJAB cells - Host Protein XAF1(BIRC4BP) http://www.ncbi.nlm.nih.gov/gene/54739 Downregulation Predicted. 18075594 We therefore manually checked mRNAs that were significantly downregulated for additional seed matches using the Entrez database. Downregulated mRNAs carrying a >6 nt seed match to miR-K12?11 were considered candidate direct targets and are listed in Suppl. Table 1. HHID00011719 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-34a(miR-34a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000268 Lymphoblastoid cell lines - Host Protein TP53(P53) http://www.ncbi.nlm.nih.gov/gene/7157 - Growth experiments/Western blotting/Quantitative real-time(qRT) PCR. 22496226 However,one miRNA described as a p53-targeted tumor suppressor, miR-34a, was strongly induced by EBV infection and expressed in many EBV and Kaposi's sarcoma-associated herpesvirus(KSHV)-infected lymphoma cell lines. HHID00011720 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-608(hsa-miR-608) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003621 HEK293 and HeLa cells - Host Protein IL-6(hIL6) http://www.ncbi.nlm.nih.gov/gene/3569 Downregulation Immunohistochemistry and Immunofluorescence, qRT-PCR, Transient cotransfection, ELISA, Western blot analysis. 21984125 We show a direct repression of vIL6 by hsa-miR-1293 and hIL6 by hsa-miR-608. The repression of vIL6 by miR-1293 was reversed by disruption of the vIL6 miR-1293 seed match through the introduction of point mutations. In addition, expression of vIL6 or hIL6 in KSHV-infected cells could be enhanced by transfection of the respective miRNA inhibitors. HHID00011721 Marek's disease virus(MDV) Gallus gallus Host miRNA gga-mir-26a(gga-miR-26a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001187 Chicken lymphoma cells Downregulation Host Protein IL-2 http://www.ncbi.nlm.nih.gov/gene/373958 - Analysis of miRNA expression, Analysis of IL-2 expression, reporter and biochemical assays. 20441582 The expression levels of gga-miR-26a in chicken lymphoma cells transformed by 3 distinct avian oncogenic viruses, viz Marek's disease virus (MDV), avian leukosis virus (ALV) and Reticuloendotheliosis virus (REV) were consistently downregulated compared to the levels in the normal lymphocytes. We demonstrate the additional role of this miRNA in directly targeting chicken IL-2 through reporter and biochemical assays. The downregulation of miR-26a can relieve the suppressive effect of this miRNA on IL-2 expression. HHID00011722 Marek's disease virus 1(MDV-1) Gallus gallus Host miRNA gga-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001176 Ovary,fibroblast cell line. - Host Protein CEBPE(C/EBP) http://www.ncbi.nlm.nih.gov/gene/396185 - RNA isolation and miRNA northern blotting analysis, Luciferase reporter assays. 20680360 We showed that mdv1-miR-M4-5P and miR-155 efficiently targeted a common set of 3' untranslated regions(3'UTR) of six cellular genes(GPM6B, RREB1, c-Myb, MAP3K7IP2, PU.1 and C/EBP). HHID00011723 Marek's disease virus 1(MDV-1) Gallus gallus Host miRNA gga-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001176 Ovary,fibroblast cell line. - Host Protein GPM6B http://www.ncbi.nlm.nih.gov/gene/418632 - RNA isolation and miRNA northern blotting analysis, Luciferase reporter assays. 20680360 We showed that mdv1-miR-M4-5P and miR-155 efficiently targeted a common set of 3' untranslated regions(3'UTR) of six cellular genes(GPM6B, RREB1, c-Myb, MAP3K7IP2, PU.1 and C/EBP). HHID00011724 Marek's disease virus 1(MDV-1) Gallus gallus Host miRNA gga-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001176 Ovary,fibroblast cell line. - Host Protein MYB(c-Myb) http://www.ncbi.nlm.nih.gov/gene/396244 - RNA isolation and miRNA northern blotting analysis, Luciferase reporter assays. 20680360 We showed that mdv1-miR-M4-5P and miR-155 efficiently targeted a common set of 3' untranslated regions(3'UTR) of six cellular genes(GPM6B, RREB1, c-Myb, MAP3K7IP2, PU.1 and C/EBP). HHID00011725 Marek's disease virus 1(MDV-1) Gallus gallus Host miRNA gga-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001176 Ovary,fibroblast cell line. - Host Protein RREB1 http://www.ncbi.nlm.nih.gov/gene/395920 - RNA isolation and miRNA northern blotting analysis, Luciferase reporter assays. 20680360 We showed that mdv1-miR-M4-5P and miR-155 efficiently targeted a common set of 3' untranslated regions(3'UTR) of six cellular genes(GPM6B, RREB1, c-Myb, MAP3K7IP2, PU.1 and C/EBP). HHID00011726 Marek's disease virus 1(MDV-1) Gallus gallus Host miRNA gga-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001176 Ovary,fibroblast cell line. - Host Protein TAB2(MAP3K7IP2) http://www.ncbi.nlm.nih.gov/gene/421622 - RNA isolation and miRNA northern blotting analysis, Luciferase reporter assays. 20680360 We showed that mdv1-miR-M4-5P and miR-155 efficiently targeted a common set of 3' untranslated regions(3'UTR) of six cellular genes(GPM6B, RREB1, c-Myb, MAP3K7IP2, PU.1 and C/EBP). HHID00011727 Marek's disease virus(MDV) Gallus gallus Host miRNA gga-mir-181a(gga-miR-181a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001218 Liver cells - Host Protein IGF2BP3 http://www.ncbi.nlm.nih.gov/gene/420617 - Luciferase reporter gene assay. 23226446 To investigate host miRNA expression profiles in the tumor transformation phase of MDV infection, we performed deep sequencing in two MDV-infected samples. The luciferase reporter gene assay showed interactions of gga-miR-181a with MYBL1, gga-miR-181a with IGF2BP3, and gga-miR-26a with EIF3A. HHID00011728 Marek's disease virus(MDV) Gallus gallus Host miRNA gga-mir-26a(gga-miR-26a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001187 Liver cells - Host Protein EIF3A http://www.ncbi.nlm.nih.gov/gene/423927 - Luciferase reporter gene assay. 23226446 To investigate host miRNA expression profiles in the tumor transformation phase of MDV infection, we performed deep sequencing in two MDV-infected samples. The luciferase reporter gene assay showed interactions of gga-miR-181a with MYBL1, gga-miR-181a with IGF2BP3, and gga-miR-26a with EIF3A. HHID00011729 Moloney murine leukemia virus(MoMuLV) Mus musculus Host miRNA mmu-mir-15a(miRNA-15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000564 - - Host Protein BCL2 http://www.ncbi.nlm.nih.gov/gene/12043 - Microarray analysis, Western blot analysis, Statistical analysis, RT-PCR. 20201611 The retrovirus ts1 is a mutant of Moloney murine leukemia virus (MoMuLV) that causes neurodegeneration (ND) in susceptible mice.Our data showed that GVT treatment of ts1-infected mice significantly increased their expression of Bcl-2 and VEGF in brainstem compared with ts1-infected untreated mice. We also studied the expression of specific microRNAs (miRNAs) such as miRNA-15 and -16 (targeting Bcl-2), and miRNA-20 (targeting VEGF). We found that the expression of miRNAs inversely correlated with the upregulation of their target proteins in ts1-infected untreated as well as in GVT-treated-ts1-infected mice. HHID00011730 Moloney murine leukemia virus(MoMuLV) Mus musculus Host miRNA mmu-mir-15b(miRNA-15) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000140 Thymus-bone marrow cellline(TB cells) - Host Protein BCL2 http://www.ncbi.nlm.nih.gov/gene/12043 - Microarray analysis, Western blot analysis, Statistical analysis, RT-PCR. 20201611 The retrovirus ts1 is a mutant of Moloney murine leukemia virus (MoMuLV) that causes neurodegeneration (ND) in susceptible mice.Our data showed that GVT treatment of ts1-infected mice significantly increased their expression of Bcl-2 and VEGF in brainstem compared with ts1-infected untreated mice. We also studied the expression of specific microRNAs (miRNAs) such as miRNA-15 and -16 (targeting Bcl-2), and miRNA-20 (targeting VEGF). We found that the expression of miRNAs inversely correlated with the upregulation of their target proteins in ts1-infected untreated as well as in GVT-treated-ts1-infected mice. HHID00011731 Moloney murine leukemia virus(MoMuLV) Mus musculus Host miRNA mmu-mir-16(miRNA-16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000565 Thymus-bone marrow cellline(TB cells) - Host Protein BCL2 http://www.ncbi.nlm.nih.gov/gene/12043 - Microarray analysis, Western blot analysis, Statistical analysis, RT-PCR. 20201611 The retrovirus ts1 is a mutant of Moloney murine leukemia virus (MoMuLV) that causes neurodegeneration (ND) in susceptible mice.Our data showed that GVT treatment of ts1-infected mice significantly increased their expression of Bcl-2 and VEGF in brainstem compared with ts1-infected untreated mice. We also studied the expression of specific microRNAs (miRNAs) such as miRNA-15 and -16 (targeting Bcl-2), and miRNA-20 (targeting VEGF). We found that the expression of miRNAs inversely correlated with the upregulation of their target proteins in ts1-infected untreated as well as in GVT-treated-ts1-infected mice. HHID00011732 Moloney murine leukemia virus(MoMuLV) Mus musculus Host miRNA mmu-mir-20a(miRNA-20) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000568 Thymus-bone marrow cellline(TB cells) - Host Protein VEGF http://www.ncbi.nlm.nih.gov/gene/22339 - Microarray analysis, Western blot analysis, Statistical analysis, RT-PCR. 20201611 The retrovirus ts1 is a mutant of Moloney murine leukemia virus (MoMuLV) that causes neurodegeneration (ND) in susceptible mice.Our data showed that GVT treatment of ts1-infected mice significantly increased their expression of Bcl-2 and VEGF in brainstem compared with ts1-infected untreated mice. We also studied the expression of specific microRNAs (miRNAs) such as miRNA-15 and -16 (targeting Bcl-2), and miRNA-20 (targeting VEGF). We found that the expression of miRNAs inversely correlated with the upregulation of their target proteins in ts1-infected untreated as well as in GVT-treated-ts1-infected mice. HHID00011733 Moloney murine leukemia virus(MoMuLV) Mus musculus Host miRNA mmu-mir-20b(miRNA-20) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003536 Thymus-bone marrow cellline(TB cells) - Host Protein VEGF http://www.ncbi.nlm.nih.gov/gene/22339 - Microarray analysis, Western blot analysis, Statistical analysis, RT-PCR. 20201611 The retrovirus ts1 is a mutant of Moloney murine leukemia virus (MoMuLV) that causes neurodegeneration (ND) in susceptible mice.Our data showed that GVT treatment of ts1-infected mice significantly increased their expression of Bcl-2 and VEGF in brainstem compared with ts1-infected untreated mice. We also studied the expression of specific microRNAs (miRNAs) such as miRNA-15 and -16 (targeting Bcl-2), and miRNA-20 (targeting VEGF). We found that the expression of miRNAs inversely correlated with the upregulation of their target proteins in ts1-infected untreated as well as in GVT-treated-ts1-infected mice. HHID00011734 Porcine reproductive and respiratory syndrome virus(PRRSV) Sus scrofa Host miRNA ssc-mir-125b(miR-125b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013172 MARC-145 cell line and primary porcine alveolar macrophages Downregulation Host Protein NFKB # - Western blot assays. 23409058 Mechanistically,miR-125b did not target the PRRSV genome. Rather, it inhibited activation of NFKB, which we found to be required for PRRSV replication.PRRSV, in turn, down-regulated miR-125b expression post-infection to promote viral replication. HHID00011735 Human respiratory syncytial virus(RSV) Homo sapiens Host miRNA hsa-let-7f(let-7f) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 A549 - Host Protein CCL7 http://www.ncbi.nlm.nih.gov/gene/6354 Downregulation qPCR for validation of miRNA microarray data,Computational analysis of miRNA targets,Luc–UTR reporter plasmid design and Luc reporter assays,RISC immunoprecipitation assays,miRNA transfections and virus replication and plaque assays. 22894925 In this study, it was shown that RSV infection of a human alveolar epithelial cell line (A549) induced five miRNAs (let-7f, miR-24, miR-337-3p, miR-26b and miR-520a-5p) and repressed two miRNAs (miR-198 and miR-595), and showed that RSV G protein triggered let-7f expression. Luciferase-untranslated region reporters and miRNA mimics and inhibitors validated the predicted targets, which included cell-cycle genes (CCND1, DYRK2 and ELF4), a chemokine gene (CCL7) and the suppressor of cytokine signalling 3 gene (SOCS3). HHID00011736 Human respiratory syncytial virus(RSV) Homo sapiens Host miRNA hsa-let-7f(let-7f) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 A549 - Host Protein CCND1 http://www.ncbi.nlm.nih.gov/gene/595 Downregulation qPCR for validation of miRNA microarray data,Computational analysis of miRNA targets,Luc–UTR reporter plasmid design and Luc reporter assays,RISC immunoprecipitation assays,miRNA transfections and virus replication and plaque assays. 22894925 In this study, it was shown that RSV infection of a human alveolar epithelial cell line (A549) induced five miRNAs (let-7f, miR-24, miR-337-3p, miR-26b and miR-520a-5p) and repressed two miRNAs (miR-198 and miR-595), and showed that RSV G protein triggered let-7f expression. Luciferase-untranslated region reporters and miRNA mimics and inhibitors validated the predicted targets, which included cell-cycle genes (CCND1, DYRK2 and ELF4), a chemokine gene (CCL7) and the suppressor of cytokine signalling 3 gene (SOCS3). HHID00011737 Human respiratory syncytial virus(RSV) Homo sapiens Host miRNA hsa-let-7f(let-7f) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 A549 - Host Protein DYRK2 http://www.ncbi.nlm.nih.gov/gene/8445 Downregulation qPCR for validation of miRNA microarray data,Computational analysis of miRNA targets,Luc–UTR reporter plasmid design and Luc reporter assays,RISC immunoprecipitation assays,miRNA transfections and virus replication and plaque assays. 22894925 In this study, it was shown that RSV infection of a human alveolar epithelial cell line (A549) induced five miRNAs (let-7f, miR-24, miR-337-3p, miR-26b and miR-520a-5p) and repressed two miRNAs (miR-198 and miR-595), and showed that RSV G protein triggered let-7f expression. Luciferase-untranslated region reporters and miRNA mimics and inhibitors validated the predicted targets, which included cell-cycle genes (CCND1, DYRK2 and ELF4), a chemokine gene (CCL7) and the suppressor of cytokine signalling 3 gene (SOCS3). HHID00011738 Human respiratory syncytial virus(RSV) Homo sapiens Host miRNA hsa-let-7f(let-7f) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 A549 - Host Protein ELF4 http://www.ncbi.nlm.nih.gov/gene/2000 Downregulation qPCR for validation of miRNA microarray data,Computational analysis of miRNA targets,Luc–UTR reporter plasmid design and Luc reporter assays,RISC immunoprecipitation assays,miRNA transfections and virus replication and plaque assays. 22894925 In this study, it was shown that RSV infection of a human alveolar epithelial cell line (A549) induced five miRNAs (let-7f, miR-24, miR-337-3p, miR-26b and miR-520a-5p) and repressed two miRNAs (miR-198 and miR-595), and showed that RSV G protein triggered let-7f expression. Luciferase-untranslated region reporters and miRNA mimics and inhibitors validated the predicted targets, which included cell-cycle genes (CCND1, DYRK2 and ELF4), a chemokine gene (CCL7) and the suppressor of cytokine signalling 3 gene (SOCS3). HHID00011739 Human respiratory syncytial virus(RSV) Homo sapiens Host miRNA hsa-let-7f(let-7f) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 A549 - Host Protein SOCS3 http://www.ncbi.nlm.nih.gov/gene/9021 Downregulation qPCR for validation of miRNA microarray data,Computational analysis of miRNA targets,Luc–UTR reporter plasmid design and Luc reporter assays,RISC immunoprecipitation assays,miRNA transfections and virus replication and plaque assays. 22894925 In this study, it was shown that RSV infection of a human alveolar epithelial cell line (A549) induced five miRNAs (let-7f, miR-24, miR-337-3p, miR-26b and miR-520a-5p) and repressed two miRNAs (miR-198 and miR-595), and showed that RSV G protein triggered let-7f expression. Luciferase-untranslated region reporters and miRNA mimics and inhibitors validated the predicted targets, which included cell-cycle genes (CCND1, DYRK2 and ELF4), a chemokine gene (CCL7) and the suppressor of cytokine signalling 3 gene (SOCS3). HHID00011740 Human respiratory syncytial virus(RSV) Homo sapiens Host miRNA hsa-mir-221(miR-221) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000298 Bronchial epithelial cells Downregulation Host Protein NGF http://www.ncbi.nlm.nih.gov/gene/4803 Downregulation Confocal microscopy, Virus titration, FACS, qPCR, miRNA analysis, Statistical analysis, Transfection. 22272270 Among the selected miRNAs, miR-221 was significantly downregulation by RSV and its transfection in bronchial epithelial cells maximally inhibited gene and protein expression of NGF and TrKA, increased apoptotic cell death, and reduced viral replication and infectivity. HHID00011741 Human respiratory syncytial virus(RSV) Homo sapiens Host miRNA hsa-mir-221(miR-221) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000298 Bronchial epithelial cells Downregulation Host Protein NTRK1(TrKA) http://www.ncbi.nlm.nih.gov/gene/4914 Downregulation Confocal microscopy, Virus titration, FACS, qPCR, miRNA analysis, Statistical analysis, Transfection. 22272270 Among the selected miRNAs, miR-221 was significantly downregulation by RSV and its transfection in bronchial epithelial cells maximally inhibited gene and protein expression of NGF and TrKA, increased apoptotic cell death, and reduced viral replication and infectivity. HHID00011742 Human respiratory syncytial virus(RSV) Homo sapiens Host miRNA hsa-mir-24(miR-24) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000080 A549 - Host Protein DYRK2 http://www.ncbi.nlm.nih.gov/gene/8445 Downregulation qPCR for validation of miRNA microarray data,Computational analysis of miRNA targets,Luc–UTR reporter plasmid design and Luc reporter assays,RISC immunoprecipitation assays,miRNA transfections and virus replication and plaque assays. 22894925 In this study, it was shown that RSV infection of a human alveolar epithelial cell line (A549) induced five miRNAs (let-7f, miR-24, miR-337-3p, miR-26b and miR-520a-5p) and repressed two miRNAs (miR-198 and miR-595), and showed that RSV G protein triggered let-7f expression. Luciferase-untranslated region reporters and miRNA mimics and inhibitors validated the predicted targets, which included cell-cycle genes (CCND1, DYRK2 and ELF4), a chemokine gene (CCL7) and the suppressor of cytokine signalling 3 gene (SOCS3). HHID00011743 Reticuloendotheliosis virus(REV) Gallus gallus Host miRNA gga-mir-26a(gga-miR-26a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001187 Chicken lymphoma cells Downregulation Host Protein IL-2 http://www.ncbi.nlm.nih.gov/gene/373958 - Analysis of miRNA expression, Analysis of IL-2 expression, reporter and biochemical assays. 20441582 The expression levels of gga-miR-26a in chicken lymphoma cells transformed by 3 distinct avian oncogenic viruses, viz Marek's disease virus (MDV), avian leukosis virus (ALV) and Reticuloendotheliosis virus (REV) were consistently downregulated compared to the levels in the normal lymphocytes. We demonstrate the additional role of this miRNA in directly targeting chicken IL-2 through reporter and biochemical assays. The downregulation of miR-26a can relieve the suppressive effect of this miRNA on IL-2 expression. HHID00011744 Simian immunodeficiency virus(SIV) Simian Host miRNA miR-142-3p # HEK293T cells Upregulation Host Protein SIRT1 # Downregulation Luciferase reporter assays. 23752207 qRT-PCR revealed up-regulation of miR-142-3p (6.4-fold) and -5p (3.9-fold) and down-regulation of SIRT1 (33-fold) in macrophages/microglia from animals with SIVE. HHID00011745 Simian immunodeficiency virus(SIV) Simian Host miRNA miR-142-5p # HEK293T cells Upregulation Host Protein SIRT1 # Downregulation Luciferase reporter assays. 23752207 qRT-PCR revealed up-regulation of miR-142-3p (6.4-fold) and -5p (3.9-fold) and down-regulation of SIRT1 (33-fold) in macrophages/microglia from animals with SIVE. HHID00011746 Soybean mosaic virus(SMV) Glycine max Host miRNA gma-miR160(miR160) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001774 Stem-loop Upregulation Host Protein ARF http://www.ncbi.nlm.nih.gov/gene/547532 - 5'-RACE analysis. 23328897 In our experiments, miR160 and miR393 were up-regulated after SMV infection. Auxin response factor(ARF) is a class of transcription factors that play a role in plant signal transduction and development. miR160, miR167 and miR390 all target ARFs, directly or indirectly. we predicted 346 potential targets of these identified miRNAs, and verified 12 targets by modified 5'-RACE analysis. Finally, three miRNAs(miR160, miR393 and miR1510) that are involved in plant resistance were observed to respond to SMV infection. HHID00011747 Tomato aspermy virus(TAV) Solanum lycopersicum Host miRNA sly-MIR159(miR159) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0009974 - - Host Protein MYB http://www.ncbi.nlm.nih.gov/gene/100125893 Upregulation Microarray analysis, RT-PCR. 23277401 AGO1 level in CMV-Fny and CMV-Fny-satT1 infections, ARF10, MYB and NAC1 levels in CMV-Fny2b infection, and AP2, MYB and NAC1 levels in TAV-Bj infection were approximately double those of mock-inoculated plants.The transcript levels of SPL, MYB, ARF10, DCL1, NAC1, ARF8, AGO1, SCL and AP2, as targets of miR156, miR159, miR160, miR162, miR164, miR167, miR168, miR171 and miR172 were also quantified using the same RNA preparations. HHID00011748 Tomato aspermy virus(TAV) Solanum lycopersicum Host miRNA sly-MIR164a(miR164) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0027570 - - Host Protein NAC1 http://www.ncbi.nlm.nih.gov/gene/543917 - RT-PCR. 21590278 NAC1, HD-ZIP and TCP4, were up-regulated during the pathogenic processes after CMV-Fny, CMV-Fny-satT1 and TAV-Bj infections. NAC1 is regulated by miR164, it has been reported that NAC1 controls lamina outgrowth on a grander scale than that of serrations [24]. Reduction of NAC gene function in a wide range of compound leaved plants reduces the number of leaflet and results in leaflet fusions as well as suppressing serrations [25, 26]. MiR165/166-regulated HD-ZIP is important for establishing the adaxial cell fate during leaf dorso-ventral patterning. MiR319-regulated TCP4 is also indispensable for proper leaf morphogenesis and leaf senescence [24, 27]. HHID00011749 Tomato aspermy virus(TAV) Solanum lycopersicum Host miRNA sly-MIR164a(miR164) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0027570 - - Host Protein NAC1 http://www.ncbi.nlm.nih.gov/gene/543917 Upregulation Microarray analysis, RT-PCR. 23277401 In the closed flower bud, the expression levels of NAC1 were most significantly increased in CMV-Fny, CMV-Fny-satT1 and TAV-Bj infections (RQ >15).The transcript levels of SPL, MYB, ARF10, DCL1, NAC1, ARF8, AGO1, SCL and AP2, as targets of miR156, miR159, miR160, miR162, miR164, miR167, miR168, miR171 and miR172 were also quantified using the same RNA preparations. HHID00011750 Tomato aspermy virus(TAV) Solanum lycopersicum Host miRNA sly-MIR164b(miR164) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0027571 - - Host Protein NAC1 http://www.ncbi.nlm.nih.gov/gene/543917 - RT-PCR. 21590278 NAC1, HD-ZIP and TCP4, were up-regulated during the pathogenic processes after CMV-Fny, CMV-Fny-satT1 and TAV-Bj infections. NAC1 is regulated by miR164, it has been reported that NAC1 controls lamina outgrowth on a grander scale than that of serrations [24]. Reduction of NAC gene function in a wide range of compound leaved plants reduces the number of leaflet and results in leaflet fusions as well as suppressing serrations [25, 26]. MiR165/166-regulated HD-ZIP is important for establishing the adaxial cell fate during leaf dorso-ventral patterning. MiR319-regulated TCP4 is also indispensable for proper leaf morphogenesis and leaf senescence [24, 27]. HHID00011751 Tomato aspermy virus(TAV) Solanum lycopersicum Host miRNA sly-MIR164b(miR164) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0027571 - - Host Protein NAC1 http://www.ncbi.nlm.nih.gov/gene/543917 Upregulation Microarray analysis, RT-PCR. 23277401 In the closed flower bud, the expression levels of NAC1 were most significantly increased in CMV-Fny, CMV-Fny-satT1 and TAV-Bj infections (RQ >15).The transcript levels of SPL, MYB, ARF10, DCL1, NAC1, ARF8, AGO1, SCL and AP2, as targets of miR156, miR159, miR160, miR162, miR164, miR167, miR168, miR171 and miR172 were also quantified using the same RNA preparations. HHID00011752 Tomato aspermy virus(TAV) Solanum lycopersicum Host miRNA sly-MIR166a(miR166) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008358 - - Host Protein HD-ZIP http://www.ncbi.nlm.nih.gov/gene/544105 - RT-PCR. 21590278 NAC1, HD-ZIP and TCP4, were up-regulated during the pathogenic processes after CMV-Fny, CMV-Fny-satT1 and TAV-Bj infections. NAC1 is regulated by miR164, it has been reported that NAC1 controls lamina outgrowth on a grander scale than that of serrations [24]. Reduction of NAC gene function in a wide range of compound leaved plants reduces the number of leaflet and results in leaflet fusions as well as suppressing serrations [25, 26]. MiR165/166-regulated HD-ZIP is important for establishing the adaxial cell fate during leaf dorso-ventral patterning. MiR319-regulated TCP4 is also indispensable for proper leaf morphogenesis and leaf senescence [24, 27]. HHID00011753 Tomato aspermy virus(TAV) Solanum lycopersicum Host miRNA sly-MIR166b(miR166) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008359 - - Host Protein HD-ZIP http://www.ncbi.nlm.nih.gov/gene/544105 - RT-PCR. 21590278 NAC1, HD-ZIP and TCP4, were up-regulated during the pathogenic processes after CMV-Fny, CMV-Fny-satT1 and TAV-Bj infections. NAC1 is regulated by miR164, it has been reported that NAC1 controls lamina outgrowth on a grander scale than that of serrations [24]. Reduction of NAC gene function in a wide range of compound leaved plants reduces the number of leaflet and results in leaflet fusions as well as suppressing serrations [25, 26]. MiR165/166-regulated HD-ZIP is important for establishing the adaxial cell fate during leaf dorso-ventral patterning. MiR319-regulated TCP4 is also indispensable for proper leaf morphogenesis and leaf senescence [24, 27]. HHID00011754 Tomato aspermy virus(TAV) Solanum lycopersicum Host miRNA sly-MIR166c(miR166) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0029105 - - Host Protein HD-ZIP http://www.ncbi.nlm.nih.gov/gene/544105 - RT-PCR. 21590278 NAC1, HD-ZIP and TCP4, were up-regulated during the pathogenic processes after CMV-Fny, CMV-Fny-satT1 and TAV-Bj infections. NAC1 is regulated by miR164, it has been reported that NAC1 controls lamina outgrowth on a grander scale than that of serrations [24]. Reduction of NAC gene function in a wide range of compound leaved plants reduces the number of leaflet and results in leaflet fusions as well as suppressing serrations [25, 26]. MiR165/166-regulated HD-ZIP is important for establishing the adaxial cell fate during leaf dorso-ventral patterning. MiR319-regulated TCP4 is also indispensable for proper leaf morphogenesis and leaf senescence [24, 27]. HHID00011755 Tomato aspermy virus(TAV) Solanum lycopersicum Host miRNA sly-MIR172a(miR172) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0009976 - - Host Protein RAV1(AP2) http://www.ncbi.nlm.nih.gov/gene/101259430 Upregulation Microarray analysis, RT-PCR. 23277401 AGO1 level in CMV-Fny and CMV-Fny-satT1 infections, ARF10, MYB and NAC1 levels in CMV-Fny2b infection, and AP2, MYB and NAC1 levels in TAV-Bj infection were approximately double those of mock-inoculated plants.The transcript levels of SPL, MYB, ARF10, DCL1, NAC1, ARF8, AGO1, SCL and AP2, as targets of miR156, miR159, miR160, miR162, miR164, miR167, miR168, miR171 and miR172 were also quantified using the same RNA preparations. HHID00011756 Tomato aspermy virus(TAV) Solanum lycopersicum Host miRNA sly-MIR172b(miR172) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0009977 - - Host Protein RAV1(AP2) http://www.ncbi.nlm.nih.gov/gene/101259430 Upregulation Microarray analysis, RT-PCR. 23277401 AGO1 level in CMV-Fny and CMV-Fny-satT1 infections, ARF10, MYB and NAC1 levels in CMV-Fny2b infection, and AP2, MYB and NAC1 levels in TAV-Bj infection were approximately double those of mock-inoculated plants.The transcript levels of SPL, MYB, ARF10, DCL1, NAC1, ARF8, AGO1, SCL and AP2, as targets of miR156, miR159, miR160, miR162, miR164, miR167, miR168, miR171 and miR172 were also quantified using the same RNA preparations. HHID00011757 Tomato aspermy virus(TAV) Solanum lycopersicum Host miRNA sly-MIR319a(miR319) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0009978 - - Host Protein TCP4 http://www.ncbi.nlm.nih.gov/gene/100736453 - RT-PCR. 21590278 NAC1, HD-ZIP and TCP4, were up-regulated during the pathogenic processes after CMV-Fny, CMV-Fny-satT1 and TAV-Bj infections. NAC1 is regulated by miR164, it has been reported that NAC1 controls lamina outgrowth on a grander scale than that of serrations [24]. Reduction of NAC gene function in a wide range of compound leaved plants reduces the number of leaflet and results in leaflet fusions as well as suppressing serrations [25, 26]. MiR165/166-regulated HD-ZIP is important for establishing the adaxial cell fate during leaf dorso-ventral patterning. MiR319-regulated TCP4 is also indispensable for proper leaf morphogenesis and leaf senescence [24, 27]. HHID00011758 Tomato aspermy virus(TAV) Solanum lycopersicum Host miRNA sly-MIR319b(miR319) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0029098 - - Host Protein TCP4 http://www.ncbi.nlm.nih.gov/gene/100736453 - RT-PCR. 21590278 NAC1, HD-ZIP and TCP4, were up-regulated during the pathogenic processes after CMV-Fny, CMV-Fny-satT1 and TAV-Bj infections. NAC1 is regulated by miR164, it has been reported that NAC1 controls lamina outgrowth on a grander scale than that of serrations [24]. Reduction of NAC gene function in a wide range of compound leaved plants reduces the number of leaflet and results in leaflet fusions as well as suppressing serrations [25, 26]. MiR165/166-regulated HD-ZIP is important for establishing the adaxial cell fate during leaf dorso-ventral patterning. MiR319-regulated TCP4 is also indispensable for proper leaf morphogenesis and leaf senescence [24, 27]. HHID00011759 Tomato aspermy virus(TAV) Solanum lycopersicum Host miRNA sly-MIR319c(miR319) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0029099 - - Host Protein TCP4 http://www.ncbi.nlm.nih.gov/gene/100736453 - RT-PCR. 21590278 NAC1, HD-ZIP and TCP4, were up-regulated during the pathogenic processes after CMV-Fny, CMV-Fny-satT1 and TAV-Bj infections. NAC1 is regulated by miR164, it has been reported that NAC1 controls lamina outgrowth on a grander scale than that of serrations [24]. Reduction of NAC gene function in a wide range of compound leaved plants reduces the number of leaflet and results in leaflet fusions as well as suppressing serrations [25, 26]. MiR165/166-regulated HD-ZIP is important for establishing the adaxial cell fate during leaf dorso-ventral patterning. MiR319-regulated TCP4 is also indispensable for proper leaf morphogenesis and leaf senescence [24, 27]. HHID00011760 Turnip mosaic virus(TuMV) Brassica napus Host miRNA bra-MIR1885a(bra-MIR1885) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008302 - - Host Protein TIR-NBS-LRR http://www.ncbi.nlm.nih.gov/protein/48762864 - Analysis of nucleic acids, Plasmid construction, Mapping of miRNA-guided cleavage site and amplification of upstream sequences of mapped target sequences. 18558089 One of the three potential miRNAs, named bra-miR1885, was verified as a true functional miRNA. It could be induced specifically by Turnip mosaic virus(TuMV) infection, and target TIR-NBS-LRR class disease-resistant transcripts for cleavage. HHID00011761 Vesicular stomatitis virus(VSV) Cricetulus griseus Host miRNA miR-706 # BHK cells - Host Protein CASP3(caspase-3) http://www.ncbi.nlm.nih.gov/gene/12367 Downregulation MTT assay, fluorescent microscopy, miRCURY LNA miR microarray analysis, Annexin V-FITC/PI analysis, phase contrast microscopy, miRNA microarray, Overexpression and inhibition of miR-706 in BHK cells, Quantitative real-time PCR, Caspase activity assays. 20625776 A laboratory-attenuated vesicular stomatitis virus induces apoptosis and alters the cellular microRNA expression profile in BHK cells. We further found that miR-706 inhibited VSV-induced apoptosis by decreasing caspase-3 and -9 activation, suggesting that induction of miR-706 expression may be a novel strategy for survival of VSV, allowing it to escape the apoptosis response of the host. HHID00011762 Vesicular stomatitis virus(VSV) Cricetulus griseus Host miRNA miR-706 # BHK cells - Host Protein Caspase-9 http://www.ncbi.nlm.nih.gov/gene/12371 Downregulation MTT assay, fluorescent microscopy, miRCURY LNA miR microarray analysis, Annexin V-FITC/PI analysis, phase contrast microscopy, miRNA microarray, Overexpression and inhibition of miR-706 in BHK cells, Quantitative real-time PCR, Caspase activity assays. 20625776 A laboratory-attenuated vesicular stomatitis virus induces apoptosis and alters the cellular microRNA expression profile in BHK cells. We further found that miR-706 inhibited VSV-induced apoptosis by decreasing caspase-3 and 10 activation, suggesting thatuction of miR-706 expression may be a novel strategy for survival of VSV, allowing it to escape the apoptosis response of the host.?ɡ. HHID00011763 Vesicular stomatitis virus(VSV) Homo sapiens Host miRNA hsa-mir-548(miRNA-548) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003593 HepG2 cells - Host Protein ISGs - - Cell culture, transfection, and detection of IFN-λ1 protein,Construction of 3′UTR reporter plasmid and luciferase reporter assay,Reverse transcription reaction and quantitative real-time PCR,Viruses and measurement of viral replication and expression,mRNA decay assay,In vitro cytotoxicity assays. 23150165 The result showed that the inhibitors of miR-548b-5p,miR-548c-5p, miR-548i, and miR-548j increased the IFN-λ1levels. These results showed that the endogenous IFN-λ1 and ISGs were regulated by miR-548. HHID00011764 Vesicular stomatitis virus(VSV) Homo sapiens Host miRNA hsa-mir-548(miRNA-548) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003593 HepG2 cells Downregulation Host Protein IFN-lambda1 http://www.ncbi.nlm.nih.gov/gene/282618 Downregulation Cell culture, transfection, and detection of IFN-λ1 protein,Construction of 3′UTR reporter plasmid and luciferase reporter assay,Reverse transcription reaction and quantitative real-time PCR,Viruses and measurement of viral replication and expression,mRNA decay assay,In vitro cytotoxicity assays. 23150165 miRNA-548 mimics promoted infection by enteroVirus-71 (EV71) and vesicular stomatitis Virus (VSV), whereas their inhibitors significantly suppressed the replication of EV71 and VSV. Endogenous miRNA-548 levels were suppressed during viral infection. In conclusion, our results suggest that miRNA-548 regulates host antiviral response via direct targeting of IFN-lambda1, which may offer a potential candidate for antiviral therapy. HVID00011765 Adeno-associated virus(AAV) Homo sapiens Host miRNA hsa-mir-142-3p(mir-142-3p) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000458 - - Virus Protein OVA # Downregulation - 23658149 The occurrence of immune responses against OVA transgene following intramuscular delivery by AAV have been described previously and resulted in the loss of OVA protein expression. In the present study, we demonstrate that OVA protein expression was maintained when mir-142-3pT sequences were incorporated into the expression cassette. The sustained expression of OVA protein over time correlated with a reduced increase in anti-OVA antibody levels. Furthermore, no cellular infiltrates were observed in the muscle tissue when AAV1 vectors containing four or eight repeats of mir-142-3p target sequences after the OVA sequence were used. HVID00011766 Adeno-associated virus(AAV) Homo sapiens Host miRNA hsa-mir-214(miR-214) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000290 Saos-2 cells - Virus Protein E1A http://www.ncbi.nlm.nih.gov/gene/1460853 Downregulation Luciferase reporter. 22982546 The activity from the same reporter was unchanged in HeLa cells, which display low-level miR-214 expression. Finally, we confirmed that the knockdown of the miR-214 upregulated the productive efficiency of the virus. These findings indicate that cellular miR-214 is capable of inhibiting adenovirus replication by regulating the translation of E1A protein. HVID00011767 Adeno-associated virus(AAV) Mus musculus Host miRNA mmu-mir-122(mir-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000256 Liver cells - Virus Protein E1A http://www.ncbi.nlm.nih.gov/gene/328572 Downregulation Luciferase reporter, Real time (quantitative) PCR (Q-PCR). 19461878 Imaging versions of these viruses, produced by fusing E1A with luciferase, showed that inclusion of mir-122 binding sites caused up to 80-fold decreased hepatic expression of E1A following intravenous delivery to mice. HVID00011768 Ascoviruses Drosophila melanogaster Host miRNA Hz-miR24 # HzFB cells Downregulation Virus mRNA DdRP # Downregulation Northern blot analyses, miRNA microarray analysis, Western blot analysis, RT-qPCR expression analysis, miRNA target studies, RNAi-mediated gene silencing. 19846520 Here, we report changes in expression levels of host miRNAs upon ascovirus infection in an insect cell line and investigated the role of a host miRNA, Hz-miR24, in the host-virus system.The specific miRNA-target interactions were investigated and confirmed using the ectopic expression of Hz-miR24 and a green fluorescent protein-based reporter system. Our functional analysis of Hz-miR24 suggested that it plays an important role in interactions with HvAV-3e by downregulating viral DdRP and DdRPbeta transcripts later in infection. HVID00011769 Ascoviruses Drosophila melanogaster Host miRNA Hz-miR24 # HzFB cells Downregulation Virus mRNA DdRPbeta # Downregulation Northern blot analyses, miRNA microarray analysis, Western blot analysis, RT-qPCR expression analysis, miRNA target studies, RNAi-mediated gene silencing. 19846520 Here, we report changes in expression levels of host miRNAs upon ascovirus infection in an insect cell line and investigated the role of a host miRNA, Hz-miR24, in the host-virus system.The specific miRNA-target interactions were investigated and confirmed using the ectopic expression of Hz-miR24 and a green fluorescent protein-based reporter system. Our functional analysis of Hz-miR24 suggested that it plays an important role in interactions with HvAV-3e by downregulating viral DdRP and DdRPbeta transcripts later in infection. HVID00011770 Borna disease virus(BDV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 human oligodendroglial (OL/BDV) cells Downregulation Virus Protein P http://www.ncbi.nlm.nih.gov/gene/1494404 - Luciferase assays. 23428672 Here, we showed that miR-155 was down-regulated in BDV persistently infected human oligodendroglial (OL/BDV) cells and that the BDV P protein, but not the X protein, directly inhibited miR-155 expression in cells. When miR-155 was over-expressed, the inhibition of type I IFNs by BDV in cells was reversed, and the expression of type I IFNs was increased. HVID00011771 Enterovirus 71(EV71) Homo sapiens Host miRNA hsa-mir-23b(miR-23b) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 - - Virus Protein VPl # Downregulation Luciferase assay. 23594713 To address this issue, biological software miRanda was first used to predict possible target sites of miR-23b at EV71 gene sequence, then to confirm it by luciferase assay. miR-23b mimics were transfected to verify its effects on infection of EV71. These results suggest that miR-23b and upregulation of miR-23b inhibited the replication of EV71 by targeting at EV71 3'UTR conserved sequence. Taken together, miR-23b could inhibit EV71 replication through downregulation of EV71 VPl protein. HVID00011772 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-106a(miR-106) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000113 EBV B95-8 LCLs and type III BL cells - Virus Protein BHRF1 http://www.ncbi.nlm.nih.gov/gene/3783706 - Western blot analysis, PAR-CLIP, qRT-PCR for RISC-associated BHRF1 mRNAs,Luciferase reporter assays. 24257599 Our analysis revealed binding sites for several cellular miRNAs, particularly the mycregulated miR-17/20/106 family, in the LMP1 and BHRF1 3'UTRs (27).EBV LMP1 and BHRF1 mRNAs are cotargeted by both viral and cellular miRNAs, such as EBV BART miRNAs and the miR-17/20/106 family, in EBV B95-8 LCLs and type III BL cells. HVID00011773 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-106a(miR-106) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000113 EBV B95-8 LCLs and type III BL cells - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - Western blot analysis, PAR-CLIP, qRT-PCR for RISC-associated BHRF1 mRNAs,Luciferase reporter assays. 24257599 Our analysis revealed binding sites for several cellular miRNAs, particularly the mycregulated miR-17/20/106 family, in the LMP1 and BHRF1 3'UTRs (27).EBV LMP1 and BHRF1 mRNAs are cotargeted by both viral and cellular miRNAs, such as EBV BART miRNAs and the miR-17/20/106 family, in EBV B95-8 LCLs and type III BL cells. HVID00011774 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-106b(miR-106) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000734 EBV B95-8 LCLs and type III BL cells - Virus Protein BHRF1 http://www.ncbi.nlm.nih.gov/gene/3783706 - Western blot analysis, PAR-CLIP, qRT-PCR for RISC-associated BHRF1 mRNAs,Luciferase reporter assays. 24257599 Our analysis revealed binding sites for several cellular miRNAs, particularly the mycregulated miR-17/20/106 family, in the LMP1 and BHRF1 3'UTRs (27).EBV LMP1 and BHRF1 mRNAs are cotargeted by both viral and cellular miRNAs, such as EBV BART miRNAs and the miR-17/20/106 family, in EBV B95-8 LCLs and type III BL cells. HVID00011775 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-106b(miR-106) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000734 EBV B95-8 LCLs and type III BL cells - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - Western blot analysis, PAR-CLIP, qRT-PCR for RISC-associated BHRF1 mRNAs,Luciferase reporter assays. 24257599 Our analysis revealed binding sites for several cellular miRNAs, particularly the mycregulated miR-17/20/106 family, in the LMP1 and BHRF1 3'UTRs (27).EBV LMP1 and BHRF1 mRNAs are cotargeted by both viral and cellular miRNAs, such as EBV BART miRNAs and the miR-17/20/106 family, in EBV B95-8 LCLs and type III BL cells. HVID00011776 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-127(hsa-miR-127) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000472 Burkitt lymphoma Upregulation Virus Protein EBNA1 http://www.ncbi.nlm.nih.gov/gene/3783774 - Luciferase assay, Quantitative reverse transcription-PCR, Indirect immunofluorescence, Western blotting(WB). 22941339 This study was designed to ascertain whether hsa-miR-127 overexpression in BL is really related to the presence of the virus.We have focused on EBNA1 as the only viral product present in EBV-positive BL. Our results show that the upregulation of hsa-miR-127 is mediated by EBNA1, shedding new light on the function of miRNAs and their regulation by viral products. HVID00011777 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 - Downregulation Virus mRNA LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - Retroviral infections, RNA isolation, BLAST analysis of miR-146a promoter versus mouse genome, Cellular mRNA microarray analysis, Cellular miRNA microarray analysis, Real-time qRT-PCR for mature miRNA and primary transcript (pri-miRNA), Transfection and luciferase expression analysis, Microarray data accession numbers, Generation of EBV-negative Mutu clones. 18057241 Through miRNA microarray analysis, we demonstrate that LMP1 dysregulates the expression of several cellular miRNAs, including the most highly regulated of these, miR-146a. Quantitative reverse transcription-PCR analysis confirmed induced expression of miR-146a by LMP1. Reporter studies demonstrated that LMP1 induces miR-146a predominantly through two NF-kappaB binding sites in the miR-146a promoter and identified a role for an Oct-1 site in conferring basal and induced expression. HVID00011778 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 CD4+ T lymphocytes - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 EBV oncoprotein LMP1 dysregulates the expression of several cellular miRNAs. LMP1 induces miR-146a predominantly through two NF-KB-binding sites in the miR-146a promoter. HVID00011779 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-146a(miRNA-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 NPC cell lines CNE1 and CNE1-GL - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - Immunohistochemical staining/qRT-PCR. 22843060 The expression of miRNA-146a in 16 cases of NPC, 13 cases of chronic nasopharyngitis and cell lines was determined by quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis. A plasmid containing the luciferase gene under the control of miRNA-146a promoter (pri-miRNA-146a) was constructed and transfected into NPC cells, and the luciferase activity was detected.The results showed that the expression levels of miRNA-146a were positively correlated with that of LMP1 protein expression. HVID00011780 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 CD4+ T lymphocytes - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 Downregulation Reporter Assay,Luciferase Reporter,Western blotting. 21152115 EBV LMP1 also induces the production of the BIC (B-cell integration cluster) precursor RNA of cellular miR-155, which is highly expressed in various B-cell lymphomas and may contribute to EBV immortalization of B cells. HVID00011781 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 NPC Samples Downregulation Virus Protein LMP-2A(LMP2A) http://www.ncbi.nlm.nih.gov/gene/3783751 - Luciferase assay. 23097559 In addition, other miRNAs such as miR-155, enhanced by EBV-encoded LMP1 and LMP2A, are associated with poor prognosis in NPC patients. miRNA expression profiling also confirmed the widespread downregulation of miRNAs in NPC samples compared with the histologically normal nasopharyngeal epithelial tissue. HVID00011782 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 NPC Samples Downregulation Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - Luciferase assay. 23097559 In addition, other miRNAs such as miR-155, enhanced by EBV-encoded LMP1 and LMP2A, are associated with poor prognosis in NPC patients. miRNA expression profiling also confirmed the widespread downregulation of miRNAs in NPC samples compared with the histologically normal nasopharyngeal epithelial tissue. HVID00011783 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-17(miR-17) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000071 EBV B95-8 LCLs and type III BL cells - Virus Protein BHRF1 http://www.ncbi.nlm.nih.gov/gene/3783706 - Western blot analysis, PAR-CLIP, qRT-PCR for RISC-associated BHRF1 mRNAs,Luciferase reporter assays. 24257599 Our analysis revealed binding sites for several cellular miRNAs, particularly the mycregulated miR-17/20/106 family, in the LMP1 and BHRF1 3'UTRs (27).EBV LMP1 and BHRF1 mRNAs are cotargeted by both viral and cellular miRNAs, such as EBV BART miRNAs and the miR-17/20/106 family, in EBV B95-8 LCLs and type III BL cells. HVID00011784 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-17(miR-17) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000071 EBV B95-8 LCLs and type III BL cells - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - Western blot analysis, PAR-CLIP, qRT-PCR for RISC-associated BHRF1 mRNAs,Luciferase reporter assays. 24257599 Our analysis revealed binding sites for several cellular miRNAs, particularly the mycregulated miR-17/20/106 family, in the LMP1 and BHRF1 3'UTRs (27).EBV LMP1 and BHRF1 mRNAs are cotargeted by both viral and cellular miRNAs, such as EBV BART miRNAs and the miR-17/20/106 family, in EBV B95-8 LCLs and type III BL cells. HVID00011785 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-18a(miR-18a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000072 EBV B95-8 LCLs - Virus mRNA LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - PAR-CLIP. 24257599 These data suggest that this site in the LMP1 3'UTR also is occupied by cellular miR-18a/b. HVID00011786 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-18b(miR-18b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001518 EBV B95-8 LCLs - Virus mRNA LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - PAR-CLIP. 24257599 These data suggest that this site in the LMP1 3'UTR also is occupied by cellular miR-18a/b. HVID00011787 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-20a(miR-20) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000076 EBV B95-8 LCLs and type III BL cells - Virus Protein BHRF1 http://www.ncbi.nlm.nih.gov/gene/3783706 - Western blot analysis, PAR-CLIP, qRT-PCR for RISC-associated BHRF1 mRNAs,Luciferase reporter assays. 24257599 Our analysis revealed binding sites for several cellular miRNAs, particularly the mycregulated miR-17/20/106 family, in the LMP1 and BHRF1 3'UTRs (27).EBV LMP1 and BHRF1 mRNAs are cotargeted by both viral and cellular miRNAs, such as EBV BART miRNAs and the miR-17/20/106 family, in EBV B95-8 LCLs and type III BL cells. HVID00011788 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-20a(miR-20) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000076 EBV B95-8 LCLs and type III BL cells - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - Western blot analysis, PAR-CLIP, qRT-PCR for RISC-associated BHRF1 mRNAs,Luciferase reporter assays. 24257599 Our analysis revealed binding sites for several cellular miRNAs, particularly the mycregulated miR-17/20/106 family, in the LMP1 and BHRF1 3'UTRs (27).EBV LMP1 and BHRF1 mRNAs are cotargeted by both viral and cellular miRNAs, such as EBV BART miRNAs and the miR-17/20/106 family, in EBV B95-8 LCLs and type III BL cells. HVID00011789 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-20b(miR-20) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001519 EBV B95-8 LCLs and type III BL cells - Virus Protein BHRF1 http://www.ncbi.nlm.nih.gov/gene/3783706 - Western blot analysis, PAR-CLIP, qRT-PCR for RISC-associated BHRF1 mRNAs,Luciferase reporter assays. 24257599 Our analysis revealed binding sites for several cellular miRNAs, particularly the mycregulated miR-17/20/106 family, in the LMP1 and BHRF1 3'UTRs (27).EBV LMP1 and BHRF1 mRNAs are cotargeted by both viral and cellular miRNAs, such as EBV BART miRNAs and the miR-17/20/106 family, in EBV B95-8 LCLs and type III BL cells. HVID00011790 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-20b(miR-20) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001519 EBV B95-8 LCLs and type III BL cells - Virus Protein LMP1 http://www.ncbi.nlm.nih.gov/gene/3783750 - Western blot analysis, PAR-CLIP, qRT-PCR for RISC-associated BHRF1 mRNAs,Luciferase reporter assays. 24257599 Our analysis revealed binding sites for several cellular miRNAs, particularly the mycregulated miR-17/20/106 family, in the LMP1 and BHRF1 3'UTRs (27).EBV LMP1 and BHRF1 mRNAs are cotargeted by both viral and cellular miRNAs, such as EBV BART miRNAs and the miR-17/20/106 family, in EBV B95-8 LCLs and type III BL cells. HVID00011791 Gallid herpesvirus 2(GaHV-2) Gallus gallus Host miRNA gga-mir-21(gga-miR-21) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004994 Virulent strain(RB-1B),vaccine strain(CVI988). Upregulation Virus Protein MDV076(Meq) http://www.ncbi.nlm.nih.gov/gene/4811549 - Luciferase assays. 23055556 We show here that the viral oncoprotein Meq binds to this promoter, thereby transactivating gga-miR-21 expression. We confirmed that this miRNA targets chicken programmed death cell 4(PDCD4) and promotes tumor cell growth and apoptosis escape. Finally, gga-miR-21 was overexpressed only during infection with a very virulent strain(RB-1B) and not during infection with a nononcogenic strain(CVI988), providing further evidence for its role in GaHV-2 lymphomagenesis. Our data therefore suggest an additional role for Meq in GaHV-2-mediated lymphomagenesis through the induction of miR-21 expression. HVID00011792 Hepatitis B virus(HBV) Homo sapiens Host LncRNA HULC http://www.lncrnadb.org/Detail.aspx?TKeyID=183 Human immortalized normal liver L-O2 cells and hepatoma HepG2 cells Upregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Luciferase reporter gene assay and chromatin immunoprecipitation(ChIP) assay. 22685290 Moreover, we revealed that HBx up-regulated HULC in human immortalized normal liver L-O2 cells and hepatoma HepG2 cells. Luciferase reporter gene assay and chromatin immunoprecipitation (ChIP) assay showed that HBx activated the HULC promoter via cAMP-responsive element-binding protein. We further demonstrated that HULC promoted cell proliferation by methyl thiazolyl tetrazolium, 5-ethynyl-2'-deoxyuridine, colony formation assay, and tumorigenicity assay. . HVID00011793 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7a(let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000060 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Reverse-transcription Taqman realtime-PCR, A microarray assay, 3'UTR-reporter assay. 20447714 Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1.5 andp-value of less than 0.01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells . HVID00011794 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7a(let-7a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000060 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - - 22425745 The mechanism by which HBV regulates cellular miRNAs is largely unknown. One possible way is through HBV x protein(HBx). HBx plays a key role in regulating HBV replication and hepatocarcinogenesis. It upregulates 7(miR-30c, -99b, -125a, -191, -193b, -199a, -342) and down-regulates 11(let-7a, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, miR-20a, -98, -106a, -196a) miRNAs in the HBx-transfected HepG2 cells in a microarray assay. HVID00011795 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7a(let-7a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000060 LO2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Immunohistochemistry, Luciferase Reporter Assay, RT-PCR and Western Blot Analysis. 22942717 Because the HBx protein trans-activates various cellular genes and pathways, we wondered whether HBx might regulate miRNA expression. This was first suggested in a 2010 study showing that the HBx protein down-regulated let-7a and promoted cell proliferation by targeting signal transducer and activator of transcription 3 (STAT 3). . HVID00011796 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7b(let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000063 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Reverse-transcription Taqman realtime-PCR, A microarray assay, 3'UTR-reporter assay. 20447714 Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1.5 andp-value of less than 0.01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells . HVID00011797 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7c(let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000064 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Reverse-transcription Taqman realtime-PCR, A microarray assay, 3'UTR-reporter assay. 20447714 Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1.5 andp-value of less than 0.01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells . HVID00011798 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7c(let-7c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000064 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - - 22425745 The mechanism by which HBV regulates cellular miRNAs is largely unknown. One possible way is through HBV x protein(HBx). HBx plays a key role in regulating HBV replication and hepatocarcinogenesis. It upregulates 7(miR-30c, -99b, -125a, -191, -193b, -199a, -342) and down-regulates 11(let-7a, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, miR-20a, -98, -106a, -196a) miRNAs in the HBx-transfected HepG2 cells in a microarray assay. HVID00011799 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7d(let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000065 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Reverse-transcription Taqman realtime-PCR, A microarray assay, 3'UTR-reporter assay. 20447714 Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1.5 andp-value of less than 0.01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells . HVID00011800 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7d(let-7d) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000065 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - - 22425745 The mechanism by which HBV regulates cellular miRNAs is largely unknown. One possible way is through HBV x protein(HBx). HBx plays a key role in regulating HBV replication and hepatocarcinogenesis. It upregulates 7(miR-30c, -99b, -125a, -191, -193b, -199a, -342) and down-regulates 11(let-7a, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, miR-20a, -98, -106a, -196a) miRNAs in the HBx-transfected HepG2 cells in a microarray assay. HVID00011801 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7e(let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000066 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Reverse-transcription Taqman realtime-PCR, A microarray assay, 3'UTR-reporter assay. 20447714 Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1.5 andp-value of less than 0.01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells . HVID00011802 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7e(let-7e) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000066 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - - 22425745 The mechanism by which HBV regulates cellular miRNAs is largely unknown. One possible way is through HBV x protein(HBx). HBx plays a key role in regulating HBV replication and hepatocarcinogenesis. It upregulates 7(miR-30c, -99b, -125a, -191, -193b, -199a, -342) and down-regulates 11(let-7a, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, miR-20a, -98, -106a, -196a) miRNAs in the HBx-transfected HepG2 cells in a microarray assay. HVID00011803 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7f(let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000067 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Reverse-transcription Taqman realtime-PCR, A microarray assay, 3'UTR-reporter assay. 20447714 Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1.5 andp-value of less than 0.01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells . HVID00011804 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7f(let-7f) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000067 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - - 22425745 The mechanism by which HBV regulates cellular miRNAs is largely unknown. One possible way is through HBV x protein(HBx). HBx plays a key role in regulating HBV replication and hepatocarcinogenesis. It upregulates 7(miR-30c, -99b, -125a, -191, -193b, -199a, -342) and down-regulates 11(let-7a, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, miR-20a, -98, -106a, -196a) miRNAs in the HBx-transfected HepG2 cells in a microarray assay. HVID00011805 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7g(let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000433 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Reverse-transcription Taqman realtime-PCR, A microarray assay, 3'UTR-reporter assay. 20447714 Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1.5 andp-value of less than 0.01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells . HVID00011806 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7g(let-7g) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000433 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - - 22425745 The mechanism by which HBV regulates cellular miRNAs is largely unknown. One possible way is through HBV x protein(HBx). HBx plays a key role in regulating HBV replication and hepatocarcinogenesis. It upregulates 7(miR-30c, -99b, -125a, -191, -193b, -199a, -342) and down-regulates 11(let-7a, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, miR-20a, -98, -106a, -196a) miRNAs in the HBx-transfected HepG2 cells in a microarray assay. HVID00011807 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7i(let-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000434 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Reverse-transcription Taqman realtime-PCR, A microarray assay, 3'UTR-reporter assay. 20447714 Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1.5 andp-value of less than 0.01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells . HVID00011808 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-let-7i(let-7i) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000434 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - - 22425745 The mechanism by which HBV regulates cellular miRNAs is largely unknown. One possible way is through HBV x protein(HBx). HBx plays a key role in regulating HBV replication and hepatocarcinogenesis. It upregulates 7(miR-30c, -99b, -125a, -191, -193b, -199a, -342) and down-regulates 11(let-7a, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, miR-20a, -98, -106a, -196a) miRNAs in the HBx-transfected HepG2 cells in a microarray assay. HVID00011809 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-miR-125a-5p(miR-125a-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 Human liver - Virus Protein S http://www.ncbi.nlm.nih.gov/gene/944569 Downregulation Computational analyses, RT-PCR, TaqMan miRNA assays, Luciferase assays. 21317190 This work shows that hsa-miR-125a-5p, a microRNA expressed in human liver, is able to down-regulate the expression of HBV S gene thus reducing the amount of secreted HBsAg. This effect will likely counteract viral replication, since it is known that (i) the expression levels of HBsAg are correlated with viral titer, and (ii) experimental knockdown of HBsAg leads to suppression of HBV replication . HVID00011810 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-miR-199a(miR-199a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000242 HepG2 cells Upregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - - 22425745 The mechanism by which HBV regulates cellular miRNAs is largely unknown. One possible way is through HBV x protein(HBx). HBx plays a key role in regulating HBV replication and hepatocarcinogenesis. It upregulates 7(miR-30c, -99b, -125a, -191, -193b, -199a, -342) and down-regulates 11(let-7a, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, miR-20a, -98, -106a, -196a) miRNAs in the HBx-transfected HepG2 cells in a microarray assay. HVID00011811 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-miR-199a-3p(miR-199a-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000232 HepG2 2.2.15 cells Upregulation Virus Protein HBVgp2(HBsAg) http://www.ncbi.nlm.nih.gov/gene/944569 Downregulation Bioinformatics analysis, real-time PCR, fluorescent reporter assay, ELISA and MTS assay, Western blot. 20728471 Compared to experimental controls, miR-199a-3p and miR-210 efficiently reduced HBsAg expression without affecting HepG2 2.2.15 cell proliferation. Quantification of HBV DNA by real-time PCR showed that both miRNAs suppressed viral replication. Bioinformatics analysis indicated a putative binding site for miR-199a-3p in the HBsAg coding region and a putative binding site for miR-210 in the HBV pre-S1 region. The direct effect of miRNAs on the target region in HBV transcripts was validated by a fluorescent reporter assay, and the suppression of HBs gene expression by both miRNAs was measured by real-time PCR and Western blot. HVID00011812 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-miR-29c(miR-29c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000735 HCC cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 Downregulation Western blot analysis, Luciferase reporter assay, Chromatin immunoprecipitation microarray (ChIP-chip) and ChIP-PCR, Quantitative real-time PCR. 21829663 Interestingly,Ct-HBx bound to and inhibited the transcriptional activity of some of these miRNA promoters. Notably, some of the examined repressed-miRNAs(miR-26a, -29c, -146a and -190) were also significantly down-regulated in a subset of HCC tissues with carboxyl-terminal HBx truncation compared to their matching non-tumor tissues, highlighting the clinical relevance of our data. HVID00011813 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-miR-338-3p(miR-338-3p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000763 LO2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Immunohistochemistry, Luciferase Reporter Assay, RT-PCR and Western Blot Analysis. 22942717 Overall, this study demonstrates that miR-338-3p inhibits proliferation by regulating CyclinD1, and HBx down-regulates miR-338-3p in HCC. This newly identified miR-338-3p/CyclinD1 .interaction provides novel insights into HBx-mediated hepatocarcinogenesis and may facilitate therapeutic development against HCC. HVID00011814 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-101(miR-101) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000103 Hepatic cells Downregulation Virus Protein DNMT3A http://www.ncbi.nlm.nih.gov/gene/1788 Upregulation 3'-UTR reporter assay. 23124077 The direct target of miR-101, DNA methyltransferase 3A(DNMT3A), was identified in silico and validated using a 3'-UTR reporter assay. HBx(hepatitis B virus x)-mediated miR-101 down-regulation and DNMT3A up-regulation supported the enhanced DNA methylation of several tumor-suppressor genes in HBx-expressing cells. HVID00011815 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-101(miR-101) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000103 Hepatic cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - 3'-UTR reporter assay. 23124077 The direct target of miR-101, DNA methyltransferase 3A(DNMT3A), was identified in silico and validated using a 3'-UTR reporter assay. HBx(hepatitis B virus x)-mediated miR-101 down-regulation and DNMT3A up-regulation supported the enhanced DNA methylation of several tumor-suppressor genes in HBx-expressing cells. HVID00011816 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-106a(miR-106a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000113 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - - 22425745 The mechanism by which HBV regulates cellular miRNAs is largely unknown. One possible way is through HBV x protein(HBx). HBx plays a key role in regulating HBV replication and hepatocarcinogenesis. It upregulates 7(miR-30c, -99b, -125a, -191, -193b, -199a, -342) and down-regulates 11(let-7a, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, miR-20a, -98, -106a, -196a) miRNAs in the HBx-transfected HepG2 cells in a microarray assay. HVID00011817 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-106a(miR-106a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000113 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Reverse-transcription Taqman realtime-PCR, A microarray assay, 3'UTR-reporter assay. 20447714 Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1.5 andp-value of less than 0.01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells . HVID00011818 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 Serum Upregulation Virus Protein HBVgp2(HBsAg) http://www.ncbi.nlm.nih.gov/gene/944569 - Reverse transcription-TaqMan PCR(RT-PCR). 23508904 Hepatitis B Virus (HBV) infection is associated with increased expression of microRNA-122.Significant linear correlations were found between microRNA-122 or microRNA-22 and HBsAg levels and ALT levels.Serum microRNA-122 and microRNA-22 levels were analyzed in 198 patients with chronic HBV who underwent liver biopsy and were compared with quantitative measurements of HBsAg, HBeAg, HBV DNA, and other clinical and histological findings. Levels of serum microRNA-122 and microRNA-22 were determined by reverse transcription-TaqMan PCR. HVID00011819 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 Serum Upregulation Virus Protein HBVgp4(ALT) http://www.ncbi.nlm.nih.gov/gene/944568 - Reverse transcription-TaqMan PCR(RT-PCR). 23508904 Hepatitis B Virus (HBV) infection is associated with increased expression of microRNA-122.Significant linear correlations were found between microRNA-122 or microRNA-22 and HBsAg levels and ALT levels.Serum microRNA-122 and microRNA-22 levels were analyzed in 198 patients with chronic HBV who underwent liver biopsy and were compared with quantitative measurements of HBsAg, HBeAg, HBV DNA, and other clinical and histological findings. Levels of serum microRNA-122 and microRNA-22 were determined by reverse transcription-TaqMan PCR. HVID00011820 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-125a(miR-125a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000469 HBV-associated HCC tissues Upregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Western blot analysis, Luciferase reporter assay, Chromatin immunoprecipitation microarray (ChIP-chip) and ChIP-PCR, Quantitative real-time PCR. 21829663 For example, miR-23a and -125a up-regulation as well as miR-19a/b down-regulation by both HBx forms were verified.The differential miRNA expressions were further validated in a cohort of HBV-associated HCC tissues using real-time PCR. HVID00011821 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-125a(miR-125a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000469 HepG2 cells Upregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - - 22425745 The mechanism by which HBV regulates cellular miRNAs is largely unknown. One possible way is through HBV x protein(HBx). HBx plays a key role in regulating HBV replication and hepatocarcinogenesis. It upregulates 7(miR-30c, -99b, -125a, -191, -193b, -199a, -342) and down-regulates 11(let-7a, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, miR-20a, -98, -106a, -196a) miRNAs in the HBx-transfected HepG2 cells in a microarray assay. HVID00011822 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-125a(miR-125a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000469 HepG2 cells Upregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Reverse-transcription Taqman realtime-PCR, A microarray assay, 3'UTR-reporter assay. 20447714 Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1.5 andp-value of less than 0.01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells . HVID00011823 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-143(miR-143) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000459 Liver cells Upregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 miR-143 overexpression in HBx-transfected cells significantly promotes cell migration with no substantial effect on cell proliferation or apoptosis,Thesedata indicate that miR-143 eases HBx-controlled cell migration/invasion both in vitro and in vivo. HVID00011824 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 HCC cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 Downregulation Western blot analysis, Luciferase reporter assay, Chromatin immunoprecipitation microarray (ChIP-chip) and ChIP-PCR, Quantitative real-time PCR. 21829663 Interestingly,Ct-HBx bound to and inhibited the transcriptional activity of some of these miRNA promoters. Notably, some of the examined repressed-miRNAs(miR-26a, -29c, -146a and -190) were also significantly down-regulated in a subset of HCC tissues with carboxyl-terminal HBx truncation compared to their matching non-tumor tissues, highlighting the clinical relevance of our data. HVID00011825 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-16(miR-16) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000070 HepG2, SK-HEP-1, and Huh7 cells. Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Cell transfection, ciferase reporter assay, Cell-cycle analysis, Immunoblots, Cell viability and apoptosis analysis, Reverse-transcription polymerase chain reaction and qRT-PCR, miRNA microarrays. 21629246 Hepatitis B virus X protein altered the in vitro expression of miRNAs in host malignant hepatocytes, particularly downregulating the miR-16 family. HVID00011826 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-190a(miR-190) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000486 HCC cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 Downregulation Western blot analysis, Luciferase reporter assay, Chromatin immunoprecipitation microarray (ChIP-chip) and ChIP-PCR, Quantitative real-time PCR. 21829663 Interestingly,Ct-HBx bound to and inhibited the transcriptional activity of some of these miRNA promoters. Notably, some of the examined repressed-miRNAs(miR-26a, -29c, -146a and -190) were also significantly down-regulated in a subset of HCC tissues with carboxyl-terminal HBx truncation compared to their matching non-tumor tissues, highlighting the clinical relevance of our data. HVID00011827 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-190b(miR-190) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005545 HCC cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 Downregulation Western blot analysis, Luciferase reporter assay, Chromatin immunoprecipitation microarray (ChIP-chip) and ChIP-PCR, Quantitative real-time PCR. 21829663 Interestingly,Ct-HBx bound to and inhibited the transcriptional activity of some of these miRNA promoters. Notably, some of the examined repressed-miRNAs(miR-26a, -29c, -146a and -190) were also significantly down-regulated in a subset of HCC tissues with carboxyl-terminal HBx truncation compared to their matching non-tumor tissues, highlighting the clinical relevance of our data. HVID00011828 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-191(miR-191) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000465 HepG2 cells Upregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - - 22425745 The mechanism by which HBV regulates cellular miRNAs is largely unknown. One possible way is through HBV x protein(HBx). HBx plays a key role in regulating HBV replication and hepatocarcinogenesis. It upregulates 7(miR-30c, -99b, -125a, -191, -193b, -199a, -342) and down-regulates 11(let-7a, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, miR-20a, -98, -106a, -196a) miRNAs in the HBx-transfected HepG2 cells in a microarray assay. HVID00011829 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-191(miR-191) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000465 HepG2 cells Upregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Reverse-transcription Taqman realtime-PCR, A microarray assay, 3'UTR-reporter assay. 20447714 Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1.5 andp-value of less than 0.01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells . HVID00011830 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-193b(miR-193b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003137 HepG2 cells Upregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - - 22425745 The mechanism by which HBV regulates cellular miRNAs is largely unknown. One possible way is through HBV x protein(HBx). HBx plays a key role in regulating HBV replication and hepatocarcinogenesis. It upregulates 7(miR-30c, -99b, -125a, -191, -193b, -199a, -342) and down-regulates 11(let-7a, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, miR-20a, -98, -106a, -196a) miRNAs in the HBx-transfected HepG2 cells in a microarray assay. HVID00011831 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-193b(miR-193b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003137 HepG2 cells Upregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Reverse-transcription Taqman realtime-PCR, A microarray assay, 3'UTR-reporter assay. 20447714 Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1.5 andp-value of less than 0.01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells . HVID00011832 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-196a(miR-196a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000238 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - - 22425745 The mechanism by which HBV regulates cellular miRNAs is largely unknown. One possible way is through HBV x protein(HBx). HBx plays a key role in regulating HBV replication and hepatocarcinogenesis. It upregulates 7(miR-30c, -99b, -125a, -191, -193b, -199a, -342) and down-regulates 11(let-7a, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, miR-20a, -98, -106a, -196a) miRNAs in the HBx-transfected HepG2 cells in a microarray assay. HVID00011833 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-196a(miR-196a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000238 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Reverse-transcription Taqman realtime-PCR, A microarray assay, 3'UTR-reporter assay. 20447714 Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1.5 andp-value of less than 0.01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells . HVID00011834 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-196b(miR-196b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001150 Liver Upregulation Virus Protein HBVgp2(S) http://www.ncbi.nlm.nih.gov/gene/944569 - miRNA profiling, Solexa-sequencing, Target prediction, Analysis of expression-profile data, Consensus-scoring approach, RT-PCR. 21113793 The miRNAs miR-7, miR196b, miR433, and miR511 target the polymerase or S gene of HBV, miR205 targets the X gene, and miR345 targets the preC gene.The upregulation of miR-7 and miR196b can repress the expression of the DNA polymerase and S proteins and thus influence disease progression. . HVID00011835 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-199a(miR-199a) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000231 HepG2 cells Upregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Reverse-transcription Taqman realtime-PCR, A microarray assay, 3'UTR-reporter assay. 20447714 Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1.5 andp-value of less than 0.01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells . HVID00011836 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-199a(miR-199a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000242 HepG2 cells Upregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Reverse-transcription Taqman realtime-PCR, A microarray assay, 3'UTR-reporter assay. 20447714 Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1.5 andp-value of less than 0.01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells . HVID00011837 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-19a(miR-19a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000073 HBV-associated HCC tissues Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Western blot analysis, Luciferase reporter assay, Chromatin immunoprecipitation microarray (ChIP-chip) and ChIP-PCR, Quantitative real-time PCR. 21829663 For example, miR-23a and -125a up-regulation as well as miR-19a/b down-regulation by both HBx forms were verified.The differential miRNA expressions were further validated in a cohort of HBV-associated HCC tissues using real-time PCR.The differential miRNA expressions were further validated in a cohort of HBV-associated HCC tissues using real-time PCR. HVID00011838 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-19b(miR-19b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000074 HBV-associated HCC tissues Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Western blot analysis, Luciferase reporter assay, Chromatin immunoprecipitation microarray (ChIP-chip) and ChIP-PCR, Quantitative real-time PCR. 21829663 For example, miR-23a and -125a up-regulation as well as miR-19a/b down-regulation by both HBx forms were verified.The differential miRNA expressions were further validated in a cohort of HBV-associated HCC tissues using real-time PCR.The differential miRNA expressions were further validated in a cohort of HBV-associated HCC tissues using real-time PCR. HVID00011839 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-205(miR-205) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000285 hepatoma cells/HCC tissues Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Luciferase assays. 24576478 We previously reported that HBx suppressed miR-205 in hepatoma cells. . HVID00011840 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-205(miR205) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000285 Liver cells - Virus Protein HBVgp3(X) http://www.ncbi.nlm.nih.gov/gene/944566 - miRNA profiling, Solexa-sequencing, Target prediction, Analysis of expression-profile data, Consensus-scoring approach, RT-PCR. 21113793 We noted that miR196b and miR205 lack expression signatures in all of the nine liver samples, whereas miR-7, miR345, miR433, and miR511 had low expression counts in all the nine liver samples.The miRNAs miR-7,miR196b, miR433, and miR511 target the DNA polymerase or S gene, whereas miR205 and miR345 target the X and the preC genes, respectively. HVID00011841 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-20a(miR-20a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000076 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - - 22425745 The mechanism by which HBV regulates cellular miRNAs is largely unknown. One possible way is through HBV x protein(HBx). HBx plays a key role in regulating HBV replication and hepatocarcinogenesis. It upregulates 7(miR-30c, -99b, -125a, -191, -193b, -199a, -342) and down-regulates 11(let-7a, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, miR-20a, -98, -106a, -196a) miRNAs in the HBx-transfected HepG2 cells in a microarray assay. HVID00011842 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-20a(miR-20a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000076 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Reverse-transcription Taqman realtime-PCR, A microarray assay, 3'UTR-reporter assay. 20447714 Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1.5 andp-value of less than 0.01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells . HVID00011843 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-210(miR-210) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000286 HepG2 2.2.15 cells Upregulation Virus Protein HBVgp2(HBsAg) http://www.ncbi.nlm.nih.gov/gene/944569 Downregulation Bioinformatics analysis, real-time PCR, fluorescent reporter assay, ELISA and MTS assay, Western blot. 20728471 Compared to experimental controls, miR-199a-3p and miR-210 efficiently reduced HBsAg expression without affecting HepG2 2.2.15 cell proliferation. Quantification of HBV DNA by real-time PCR showed that both miRNAs suppressed viral replication. Bioinformatics analysis indicated a putative binding site for miR-199a-3p in the HBsAg coding region and a putative binding site for miR-210 in the HBV pre-S1 region. The direct effect of miRNAs on the target region in HBV transcripts was validated by a fluorescent reporter assay, and the suppression of HBs gene expression by both miRNAs was measured by real-time PCR and Western blot. HVID00011844 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-22(miR-22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000078 Serum Upregulation Virus Protein HBVgp2(HBsAg) http://www.ncbi.nlm.nih.gov/gene/944569 - Reverse transcription-TaqMan PCR(RT-PCR). 23508904 Hepatitis B Virus (HBV) infection is associated with increased expression of microRNA-122.Significant linear correlations were found between microRNA-122 or microRNA-22 and HBsAg levels and ALT levels.Serum microRNA-122 and microRNA-22 levels were analyzed in 198 patients with chronic HBV who underwent liver biopsy and were compared with quantitative measurements of HBsAg, HBeAg, HBV DNA, and other clinical and histological findings. Levels of serum microRNA-122 and microRNA-22 were determined by reverse transcription-TaqMan PCR. HVID00011845 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-22(miR-22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000078 Serum Upregulation Virus Protein HBVgp4(ALT) http://www.ncbi.nlm.nih.gov/gene/944568 - Reverse transcription-TaqMan PCR(RT-PCR). 23508904 Hepatitis B Virus (HBV) infection is associated with increased expression of microRNA-122.Significant linear correlations were found between microRNA-122 or microRNA-22 and HBsAg levels and ALT levels.Serum microRNA-122 and microRNA-22 levels were analyzed in 198 patients with chronic HBV who underwent liver biopsy and were compared with quantitative measurements of HBsAg, HBeAg, HBV DNA, and other clinical and histological findings. Levels of serum microRNA-122 and microRNA-22 were determined by reverse transcription-TaqMan PCR. HVID00011846 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-23a(miR-23a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000079 HBV-associated HCC tissues Upregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Western blot analysis, Luciferase reporter assay, Chromatin immunoprecipitation microarray (ChIP-chip) and ChIP-PCR, Quantitative real-time PCR. 21829663 For example, miR-23a and -125a up-regulation as well as miR-19a/b down-regulation by both HBx forms were verified.The differential miRNA expressions were further validated in a cohort of HBV-associated HCC tissues using real-time PCR. HVID00011847 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-26a(miR-26a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000083 HCC cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 Downregulation Western blot analysis, Luciferase reporter assay, Chromatin immunoprecipitation microarray (ChIP-chip) and ChIP-PCR, Quantitative real-time PCR. 21829663 Interestingly,Ct-HBx bound to and inhibited the transcriptional activity of some of these miRNA promoters. Notably, some of the examined repressed-miRNAs(miR-26a, -29c, -146a and -190) were also significantly down-regulated in a subset of HCC tissues with carboxyl-terminal HBx truncation compared to their matching non-tumor tissues, highlighting the clinical relevance of our data. HVID00011848 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-29a(miR-29a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000087 HepG2-X and H7402-X cell lines Upregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 miR-29a is also important in promoting HBV-HCC progression,and is dramatically upregulated in p21-HBx transgenic mice and in HepG2-X and H7402-X cell lines.miR-29a can ease HBx-induced hepatoma cell migration by modulating PTEN and Akt. HVID00011849 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-30c(miR-30c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000736 HepG2 cells Upregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - - 22425745 The mechanism by which HBV regulates cellular miRNAs is largely unknown. One possible way is through HBV x protein(HBx). HBx plays a key role in regulating HBV replication and hepatocarcinogenesis. It upregulates 7(miR-30c, -99b, -125a, -191, -193b, -199a, -342) and down-regulates 11(let-7a, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, miR-20a, -98, -106a, -196a) miRNAs in the HBx-transfected HepG2 cells in a microarray assay. HVID00011850 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-30c(miR-30c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000736 HepG2 cells Upregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Reverse-transcription Taqman realtime-PCR, A microarray assay, 3'UTR-reporter assay. 20447714 Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1.5 andp-value of less than 0.01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells . HVID00011851 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-342(miR-342) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000805 HepG2 cells Upregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - - 22425745 The mechanism by which HBV regulates cellular miRNAs is largely unknown. One possible way is through HBV x protein(HBx). HBx plays a key role in regulating HBV replication and hepatocarcinogenesis. It upregulates 7(miR-30c, -99b, -125a, -191, -193b, -199a, -342) and down-regulates 11(let-7a, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, miR-20a, -98, -106a, -196a) miRNAs in the HBx-transfected HepG2 cells in a microarray assay. HVID00011852 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-342(miR-342) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000805 HepG2 cells Upregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Reverse-transcription Taqman realtime-PCR, A microarray assay, 3'UTR-reporter assay. 20447714 Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1.5 andp-value of less than 0.01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells . HVID00011853 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-345(miR345) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000825 Liver cells Downregulation Virus Protein PreC http://www.ncbi.nlm.nih.gov/gene/1403693 - miRNA profiling, Solexa-sequencing, Target prediction, Analysis of expression-profile data, Consensus-scoring approach, RT-PCR. 21113793 We noted that miR196b and miR205 lack expression signatures in all of the nine liver samples, whereas miR-7, miR345, miR433, and miR511 had low expression counts in all the nine liver samples.The miRNAs miR-7, miR196b, miR433, and miR511 target the polymerase or S gene of HBV, miR205 targets the X gene, and miR345 targets the preC gene. HVID00011854 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-433(miR433) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001723 Liver cells Upregulation Virus Protein HBVgp2(S) http://www.ncbi.nlm.nih.gov/gene/944569 - miRNA profiling, Solexa-sequencing, Target prediction, Analysis of expression-profile data, Consensus-scoring approach, RT-PCR. 21113793 The miRNAs miR-7, miR196b, miR433, and miR511 target the polymerase or S gene of HBV, miR205 targets the X gene, and miR345 targets the preC gene. Furthermore, the expression level of miR-7 and miR433 were rapidly upregulated in HBV-infected and severe chronic hepatitis-B liver tissues. . HVID00011855 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-511(miR-511) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003127 Liver Downregulation Virus Protein HBVgp2(S) http://www.ncbi.nlm.nih.gov/gene/944569 - miRNA profiling, Solexa-sequencing, Target prediction, Analysis of expression-profile data, Consensus-scoring approach, RT-PCR. 21113793 We noted that miR196b and miR205 lack expression signatures in all of the nine liver samples, whereas miR-7, miR345, miR433, and miR511 had low expression counts in all the nine liver samples.The miRNAs miR-7, miR196b, miR433, and miR511 target the polymerase or S gene of HBV, miR205 targets the X gene, and miR345 targets the preC gene. HVID00011856 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-7(miR-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000263 Liver cells Upregulation Virus Protein HBVgp2(S) http://www.ncbi.nlm.nih.gov/gene/944569 - miRNA profiling, Solexa-sequencing, Target prediction, Analysis of expression-profile data, Consensus-scoring approach, RT-PCR. 21113793 The miRNAs miR-7, miR196b, miR433, and miR511 target the polymerase or S gene of HBV, miR205 targets the X gene, and miR345 targets the preC gene. Furthermore, the expression level of miR-7 and miR433 were rapidly upregulated in HBV-infected and severe chronic hepatitis-B liver tissues. . HVID00011857 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-98(miR-98) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000100 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - - 22425745 The mechanism by which HBV regulates cellular miRNAs is largely unknown. One possible way is through HBV x protein(HBx). HBx plays a key role in regulating HBV replication and hepatocarcinogenesis. It upregulates 7(miR-30c, -99b, -125a, -191, -193b, -199a, -342) and down-regulates 11(let-7a, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, miR-20a, -98, -106a, -196a) miRNAs in the HBx-transfected HepG2 cells in a microarray assay. HVID00011858 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-98(miR-98) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000100 HepG2 cells Downregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Reverse-transcription Taqman realtime-PCR, A microarray assay, 3'UTR-reporter assay. 20447714 Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1.5 andp-value of less than 0.01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells . HVID00011859 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-99b(miR-99b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000746 HepG2 cells Upregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - - 22425745 The mechanism by which HBV regulates cellular miRNAs is largely unknown. One possible way is through HBV x protein(HBx). HBx plays a key role in regulating HBV replication and hepatocarcinogenesis. It upregulates 7(miR-30c, -99b, -125a, -191, -193b, -199a, -342) and down-regulates 11(let-7a, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, miR-20a, -98, -106a, -196a) miRNAs in the HBx-transfected HepG2 cells in a microarray assay. HVID00011860 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-99b(miR-99b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000746 HepG2 cells Upregulation Virus Protein HBVgp3(HBx) http://www.ncbi.nlm.nih.gov/gene/944566 - Reverse-transcription Taqman realtime-PCR, A microarray assay, 3'UTR-reporter assay. 20447714 Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1.5 andp-value of less than 0.01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells . HVID00011861 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-let-7b(let-7b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000063 - - Virus mRNA HCVgp1(NS5B) http://www.ncbi.nlm.nih.gov/gene/951475 Downregulation Transient transfection and luciferase activity assay, Ribonucleoprotein immunoprecipitation (RIP) assay, Western-blot analysis, real-time quantitative RT-PCR. 24871972 In addition to miR-199*, let-7b was identified, which directly targets the NS5B coding region and 5'UTR sequences of the HCV genome, resulting in a decrease in HCV replicon replication, downregulation of HCV accumulation, and reduction of HCV infectivity. HVID00011862 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-let-7b(let-7b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000063 ConI replicon cells and Huh7.5 - Virus Protein HCVgp1(NS5B) http://www.ncbi.nlm.nih.gov/gene/951475 Downregulation Transient transfection and luciferase activity assay, Ribonucleoprotein immunoprecipitation (RIP) assay, Western-blot analysis, real-time quantitative RT-PCR. 22391672 In addition to miR-199*, let-7b was identified, which directly targets the NS5B coding region and 5?GUTR sequences of the HCV genome, resulting in a decrease in HCV replicon replication, downregulation of HCV accumulation, and reduction of HCV infectivity. HVID00011863 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-miR-199a(miR-199*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000232 - - Virus mRNA HCVgp1(NS5B) http://www.ncbi.nlm.nih.gov/gene/951475 Downregulation Transient transfection and luciferase activity assay, Ribonucleoprotein immunoprecipitation (RIP) assay, Western-blot analysis, real-time quantitative RT-PCR. 24871972 In addition to miR-199*, let-7b was identified, which directly targets the NS5B coding region and 5'UTR sequences of the HCV genome, resulting in a decrease in HCV replicon replication, downregulation of HCV accumulation, and reduction of HCV infectivity. HVID00011864 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 - - Virus mRNA HCVgp1(NS5B) http://www.ncbi.nlm.nih.gov/gene/951475 Downregulation Transient transfection and luciferase activity assay, Ribonucleoprotein immunoprecipitation (RIP) assay, Western-blot analysis, real-time quantitative RT-PCR. 24871972 In the case of the target site in the NS5B coding region, miR-122 was reported to inhibit HCV replication through binding to this site in the replicon system, suggesting that this binding site probably functions as a repressor for HCV replication. HVID00011865 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 9-13 replicon cells - Virus Protein NS3-5B http://www.ncbi.nlm.nih.gov/gene/951475 Downregulation Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 miR-122 antagomir can inhibit replication of HCV, abundance of HCV core RNA, and expression of HCV nonstructural proteins (NS3 in CNS3 cells and NS3-5B in 9-13 replicon cells), in a time- and dose- dependent manner. These findings are suggestive of miR-122 as a potential target for antiviral interventions in HCV patients. HVID00011866 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 CNS3 cells - Virus Protein HCVgp1(NS3) http://www.ncbi.nlm.nih.gov/gene/951475 Downregulation Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 miR-122 antagomir can inhibit replication of HCV, abundance of HCV core RNA, and expression of HCV nonstructural proteins (NS3 in CNS3 cells and NS3-5B in 9-13 replicon cells), in a time- and dose- dependent manner. These findings are suggestive of miR-122 as a potential target for antiviral interventions in HCV patients. HVID00011867 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-122(miR-122) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000442 Huh7.5.1 cells Downregulation Virus Protein HCVgp1 http://www.ncbi.nlm.nih.gov/gene/951475 - real-time PCR(RT-PCR). 23537271 The miR-122 levels in Huh7.5.1 cells infected with HCV for different days or different HCV abundance weremeasured by real-time PCR. Significant decrease of miR-122 expression was found at late stage of infection and inthe high-abundance group. Huh7.5.1 cells transfected with plasmid pEGFP-core or pEGFP were used to detect theeffects of HCV core protein on miR-122 expression, the results showed that core protein could down-regulate themiR-122 expression level in a time- and dose- dependent manner, and reduced the susceptibility of Huh7.5.1 cell toHCV. HVID00011868 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-196 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000238 Huh7.5.1 cells - Virus Protein Con1 http://www.ncbi.nlm.nih.gov/gene/951475 Downregulation Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 miR-196 has been found to inhibit HCV expression and repress HCV-induced oxidative damage. Transfection with miR-196 mimics significantly reduces HCV replicationTwo 6-nt sites within the HCV Con1 genome have been predicted to be complementary to a miR-196 region, implying that miR-196 inhibits HCV expression by directly targeting its Con1 genome. . HVID00011869 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-196(miR-196) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000238 HCV J6/JFH1 cell culture system - Virus Protein HCVgp1(NS3) http://www.ncbi.nlm.nih.gov/gene/951475 Downregulation Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 Similar downregulation of HCV NS3 protein expression by miR-196 has also been confirmed in an HCV J6/JFH1 cell culture system.Moreover, miR-196 is able to repress oxidative damage by targeting the transcription regulator protein Bach1. HVID00011870 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-196a(miR-196) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000238 HCV J6/JFH1 cells - Virus Protein HCVgp1(NS3) http://www.ncbi.nlm.nih.gov/gene/951475 Downregulation Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 Moreover, miR-196 is able to repress oxidative damage by targeting the transcription regulator protein Bach2 miR-196 has been found to inhibit HCV expression and repress HCV-induced oxidative damage. Transfection with miR-196 mimics significantly reduces HCV replication.Similar downregulation of HCV NS3 protein expression by miR-196 has also been confirmed in an HCV J6/JFH1 cell culture system. HVID00011871 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-196a(miR-196) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000238 JFH1 region of the HCV genome - Virus Protein NS5A http://www.ncbi.nlm.nih.gov/gene/951475 Downregulation Western Blot Analysis, luciferase Reporter assay, Northern Blotting. 23108868 miR-196 has been found to inhibit HCV expression and repress HCV-induced oxidative damage. Transfection with miR-196 mimics significantly reduces HCV replication. Two 6-nt sites within the HCV Con1 genome have been predicted to be complementary to a miR-196 region, implying that miR-196 inhibits HCV expression by directly targeting its Con1 genome. Additionally, miR-196 has been demonstrated to block HCV replication through its action on NS5A gene in the JFH1 region of the HCV genome . HVID00011872 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-196a(miR-196) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000238 - Upregulation Virus mRNA NS5A http://www.ncbi.nlm.nih.gov/gene/951475 Downregulation Transient transfection and luciferase activity assay, Ribonucleoprotein immunoprecipitation (RIP) assay, Western-blot analysis, real-time quantitative RT-PCR. 24871972 Two other microRNAs, miR-448 and miR-196, directly target the core and NS5A coding region of the HCV genome, respectively. Overexpression of these two miRNAs substantially reduces HCV replication. HVID00011873 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-196b(miR-196) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001150 - Upregulation Virus mRNA NS5A http://www.ncbi.nlm.nih.gov/gene/951475 Downregulation Transient transfection and luciferase activity assay, Ribonucleoprotein immunoprecipitation (RIP) assay, Western-blot analysis, real-time quantitative RT-PCR. 24871972 Two other microRNAs, miR-448 and miR-196, directly target the core and NS5A coding region of the HCV genome, respectively. Overexpression of these two miRNAs substantially reduces HCV replication. HVID00011874 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-199b(miR-199*) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000282 - - Virus mRNA HCVgp1(NS5B) http://www.ncbi.nlm.nih.gov/gene/951475 Downregulation Transient transfection and luciferase activity assay, Ribonucleoprotein immunoprecipitation (RIP) assay, Western-blot analysis, real-time quantitative RT-PCR. 24871972 In addition to miR-199*, let-7b was identified, which directly targets the NS5B coding region and 5'UTR sequences of the HCV genome, resulting in a decrease in HCV replicon replication, downregulation of HCV accumulation, and reduction of HCV infectivity. HVID00011875 Human T-cell leukemia virus 1(HTLV-1) Homo sapiens Host miRNA hsa-mir-146a(miR-146a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000477 Peripheral blood mononuclear cells Upregulation Virus Protein Tax http://www.ncbi.nlm.nih.gov/gene/1491938 - Determination of provirus copy numbers, Analysis of effects of HTLV-1 proteins on endogenous microRNAs, Isolation of PBMC and lymphocyte populations, Quantification of mature microRNAs, Promoter analysis, Statistical analysis, MicroRNA primary transcript and mRNA detection. 19014482 miR-146a expression was found to be directly stimulated by Tax via NF-KB-mediated transactivation of its promoter; a single NF-KB site proximal to the transcription start point was necessary and sufficient for this to happen. An in silico analysis of potential target genes revealed candidates that might be coregulated by two or more of the aforementioned overexpressed microRNAs. HVID00011876 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host LncRNA NEAT1 http://lncrnadb.com/Detail.aspx?TKeyID=105 Jurkat cells Upregulation Virus Protein Rev http://www.ncbi.nlm.nih.gov/gene/155908 - LncRNA profiling, Western blotting, qRT-PCR, Immunofluorescence and confocal microscopy. 23362321 Here, we report the first evidence of NEAT1 as an LncRNA involved in HIV-1 replication. We show that HIV-1 infection increases NEAT1 RNA expression by 5- to 10-fold over that for uninfected cells . Using two different approaches, siRNA and antisense DNA, we demonstrated that the knockdown of NEAT1 enhanced virus production by increasing nucleus-tocytoplasm export of Rev-dependent INS-containing HIV-1 transcripts. . HVID00011877 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host LncRNA NEAT1 http://lncrnadb.com/Detail.aspx?TKeyID=105 T cells Upregulation Virus Protein INS http://www.ncbi.nlm.nih.gov/gene/155908 Downregulation LncRNA profiling, Western blotting, qRT-PCR, Immunofluorescence and confocal microscopy. 23362321 Here, we report the first evidence of NEAT1 as an LncRNA involved in HIV-1 replication. We show that HIV-1 infection increases NEAT1 RNA expression by 5- to 10-fold over that for uninfected cells . Using two different approaches, siRNA and antisense DNA, we demonstrated that the knockdown of NEAT1 enhanced virus production by increasing nucleus-tocytoplasm export of Rev-dependent INS-containing HIV-1 transcripts. . HVID00011878 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA has-miR-20a(has-miR-20a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000076 - - Virus mRNA PCAF http://www.ncbi.nlm.nih.gov/gene/155871 Upregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HVID00011879 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-125a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004602 CD4+ T cells - Virus mRNA nef(Nef) http://www.ncbi.nlm.nih.gov/gene/156110 Downregulation Real-time reverse transcription PCR(RT-PCR). 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-2 and cellular gene products.Transcriptional control is vital to the HIV- 1 proliferation, thus determining microRNA interactions among host transcription factors and regulators is a necessity. HVID00011880 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 CD4+ T cells - Virus mRNA nef(Nef) http://www.ncbi.nlm.nih.gov/gene/156110 Downregulation Real-time reverse transcription PCR(RT-PCR). 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-2 and cellular gene products.Transcriptional control is vital to the HIV- 1 proliferation, thus determining microRNA interactions among host transcription factors and regulators is a necessity. HVID00011881 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-125b-3p(hsa-miR-125b-1*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004592 CD4+ T cells - Virus mRNA nef(Nef) http://www.ncbi.nlm.nih.gov/gene/156110 Downregulation Real-time reverse transcription PCR(RT-PCR). 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-2 and cellular gene products.Transcriptional control is vital to the HIV- 1 proliferation, thus determining microRNA interactions among host transcription factors and regulators is a necessity. HVID00011882 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 CD4+ T cells - Virus mRNA nef(Nef) http://www.ncbi.nlm.nih.gov/gene/156110 Downregulation Real-time reverse transcription PCR(RT-PCR). 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-2 and cellular gene products.Transcriptional control is vital to the HIV- 1 proliferation, thus determining microRNA interactions among host transcription factors and regulators is a necessity. HVID00011883 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-125b-5p(hsa-miR-125b-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 - - Virus mRNA Nef http://www.ncbi.nlm.nih.gov/gene/156110 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HVID00011884 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-149(hsa-miR-149) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000478 - - Virus mRNA Vpr http://www.ncbi.nlm.nih.gov/gene/155807 Downregulation - 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products. HVID00011885 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-149-5p(hsa-mir-149) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000450 - - Virus Protein vpr http://www.ncbi.nlm.nih.gov/gene/155807 - MicroRNA microarray, consensus scoring approach. 16236258 Targets for human encoded microRNAs in HIV genes. While hsa-mir-29a and 29b target the nef gene, hsa-mir-149 targets the vpr gene, hsa-mir-378 targets env, and hsa-mir-324-5p targets the vif gene. HVID00011886 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-150(miR-150) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000479 CD4+ T lymphocytes Upregulation Virus Protein Nef http://www.ncbi.nlm.nih.gov/gene/156110 - Synthesis of short interfering RNAs and microRNA inhibitors, Plasmid construction, Alu-PCR, Real-time reverse transcription PCR detection, Flow cytometric analysis, Prediction of microRNA-binding sites, MicroRNA array analysis, Transfection, Isolation and culture of primary CD4+ T cells. 21862142 They concluded that several host miRNAs (miR-125b, miR-150, miR-28, miR-223, and miR-382), which are highly expressed in resting CD4+ T lymphocytes, may target the Nef/3'LTR region and contribute to HIV-1 latency. Specific antagomirs (anti-micro RNA antisense) against these miRNAs substantially increased HIV-1 protein translation in resting CD4 cells. HVID00011887 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 - Downregulation Virus Protein KAT2B(PCAF) http://www.ncbi.nlm.nih.gov/gene/8850 Upregulation Hybridization and analysis, Reverse transcription and real-time PCR, Microarray probes, infection and flow cytometry, Transfection. 21569500 Two members of the hsa-miR-17/92 cluster, hsa-miR-17-5p and hsa-miR-20a, target the mRNA of the PCAF cofactor of Tat trans-activation. Our results and published microarrays agree in downregulation of these miRNA by HIV-1 . Their perturbation in HIV-1 infection is near the 2-fold cutoff and sensitive, and specific measurement of the expression changes by RT-qPCR is warranted. HVID00011888 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-28(miR-28) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000086 CD4+ T lymphocytes Upregulation Virus Protein Nef http://www.ncbi.nlm.nih.gov/gene/156110 - Synthesis of short interfering RNAs and microRNA inhibitors, Plasmid construction, Alu-PCR, Real-time reverse transcription PCR detection, Flow cytometric analysis, Prediction of microRNA-binding sites, MicroRNA array analysis, Transfection, Isolation and culture of primary CD4+ T cells. 21862142 They concluded that several host miRNAs (miR-125b, miR-150, miR-28, miR-223, and miR-382), which are highly expressed in resting CD4+ T lymphocytes, may target the Nef/3'LTR region and contribute to HIV-1 latency. Specific antagomirs (anti-micro RNA antisense) against these miRNAs substantially increased HIV-1 protein translation in resting CD4 cells. HVID00011889 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-29a-3p(hsa-mir-29a) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 - - Virus Protein nef http://www.ncbi.nlm.nih.gov/gene/156110 - MicroRNA microarray, consensus scoring approach. 16236258 Targets for human encoded microRNAs in HIV genes. While hsa-mir-29a and 29b target the nef gene, hsa-mir-149 targets the vpr gene, hsa-mir-378 targets env, and hsa-mir-324-5p targets the vif gene. HVID00011890 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-29a-5p(hsa-miR-29a*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004503 CD4+ T cells - Virus mRNA nef(Nef) http://www.ncbi.nlm.nih.gov/gene/156110 Downregulation Real-time reverse transcription PCR(RT-PCR), Reporter assay. 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-2 and cellular gene products.Transcriptional control is vital to the HIV- 1 proliferation, thus determining microRNA interactions among host transcription factors and regulators is a necessity. HVID00011891 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-29b(microRNA-29b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000105 CD4(+)CD8(-) PBMCs Downregulation Virus Protein Nef http://www.ncbi.nlm.nih.gov/gene/156110 - Dual Luciferase reporter assays, Immunobloting, HIV sequence search and alignment, Cell cycle analysis, northern blot. 22080513 we find that several host microRNAs are significantly up- or downregulated around the time HIV-1 infection peaks in vitro.While microRNA-223 levels were significantly enriched in HIV-1-infected CD4+CD8PBMCs,microRNA-29a/b, microRNA-155 and microRNA-21 levels were significantly reduced.Based on the potential for microRNA binding sites in a conserved sequence of the Nef-3'-LTR, several host microRNAs potentially could affect HIV-1 gene expression.Among those microRNAs, the microRNA-29 family has seed complementarity in the HIV-1 3'-UTR, but the potential suppressive effect of microRNA-29 on HIV-1 is severely blocked by the secondary structure of the target region. HVID00011892 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-29b-3p(hsa-mir-29b) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000100 - - Virus Protein nef http://www.ncbi.nlm.nih.gov/gene/156110 - MicroRNA microarray, consensus scoring approach. 16236258 Targets for human encoded microRNAs in HIV genes. While hsa-mir-29a and 29b target the nef gene, hsa-mir-149 targets the vpr gene, hsa-mir-378 targets env, and hsa-mir-324-5p targets the vif gene. HVID00011893 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-324-5p(hsa-mir-324-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000761 - - Virus Protein vif http://www.ncbi.nlm.nih.gov/gene/155459 - MicroRNA microarray, consensus scoring approach. 16236258 Targets for human encoded microRNAs in HIV genes. While hsa-mir-29a and 29b target the nef gene, hsa-mir-149 targets the vpr gene, hsa-mir-378 targets env, and hsa-mir-324-5p targets the vif gene. HVID00011894 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-miR-378(miR-378) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000786 - - Virus Protein Vpu http://www.ncbi.nlm.nih.gov/gene/155945 - - 21786074 Targets vpu.Table 1 Functions of cellular miRNAs identified in HIV.Table 1 summarizes the list of cellular miRNAs identified in relation to HIV/AIDS, the functions of which are discussed in this review. HVID00011895 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-125b(miR-125b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000446 CD4+ T cells - Virus Protein rev(Rev) http://www.ncbi.nlm.nih.gov/gene/155908 Downregulation Synthesis of short interfering RNAs and microRNA inhibitors, Plasmid construction, Alu-PCR, Real-time reverse transcription PCR detection, Flow cytometric analysis, Prediction of microRNA-binding sites, MicroRNA array analysis, Transfection, Isolation and culture of primary CD4+ T cells. 17906637 We have found that the 3'ends of HIV-1 messenger RNAs are targeted by a cluster of cellular miRNAs including miR-28, miR-125b, miR-150, miR-223 and miR-382, which are enriched in resting CD4+ T cells as compared to activated CD4+ T cells.It is known that every spliced or unspliced HIV-1 mRNA, with the exception of Nef-encoding mRNA, contains the 1.2-kb fragment we used (or a portion of it) in its 3'UTR25 . Thus, these cellular miRNAs, which bind the 1.2-kb fragment of the HIV-1 RNA 3'end, can inhibit the translation of almost all HIV-1-encoded proteins-including Tat and Rev, which are key in the transcription and translocation of viral RNA. HVID00011896 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-125b(miR-125b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000446 CD4+ T cells - Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 Downregulation Synthesis of short interfering RNAs and microRNA inhibitors, Plasmid construction, Alu-PCR, Real-time reverse transcription PCR detection, Flow cytometric analysis, Prediction of microRNA-binding sites, MicroRNA array analysis, Transfection, Isolation and culture of primary CD4+ T cells. 17906637 We have found that the 3'ends of HIV-1 messenger RNAs are targeted by a cluster of cellular miRNAs including miR-28, miR-125b, miR-150, miR-223 and miR-382, which are enriched in resting CD4+ T cells as compared to activated CD4+ T cells.It is known that every spliced or unspliced HIV-1 mRNA, with the exception of Nef-encoding mRNA, contains the 1.2-kb fragment we used (or a portion of it) in its 3'UTR25 . Thus, these cellular miRNAs, which bind the 1.2-kb fragment of the HIV-1 RNA 3'end, can inhibit the translation of almost all HIV-1-encoded proteins-including Tat and Rev, which are key in the transcription and translocation of viral RNA. HVID00011897 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-125b(miR-125b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000446 CD4+ T lymphocytes Upregulation Virus Protein Nef http://www.ncbi.nlm.nih.gov/gene/156110 - Synthesis of short interfering RNAs and microRNA inhibitors, Plasmid construction, Alu-PCR, Real-time reverse transcription PCR detection, Flow cytometric analysis, Prediction of microRNA-binding sites, MicroRNA array analysis, Transfection, Isolation and culture of primary CD4+ T cells. 21862142 They concluded that several host miRNAs (miR-125b, miR-150, miR-28, miR-223, and miR-382), which are highly expressed in resting CD4+ T lymphocytes, may target the Nef/3'LTR region and contribute to HIV-1 latency. Specific antagomirs (anti-micro RNA antisense) against these miRNAs substantially increased HIV-1 protein translation in resting CD4 cells. HVID00011898 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-149(hsa-miR-149) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000478 CD4+ T cells - Virus mRNA vpr(Vpr) http://www.ncbi.nlm.nih.gov/gene/155807 Downregulation Microarray analysis. 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-2 and cellular gene products.Transcriptional control is vital to the HIV- 1 proliferation, thus determining microRNA interactions among host transcription factors and regulators is a necessity. HVID00011899 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-149(miR-149) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000478 - - Virus Protein Vpr http://www.ncbi.nlm.nih.gov/gene/155807 - - 21786074 Target prediction analysis by Nathans et al. suggested that the HIV-1 3'-UTR can be targeted by 11 miRNAs(miR-29a, 29b, 29c, 149, 147, 138, 513, 516-5p, 581, 644, and 647. HVID00011900 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-149(miR149) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000478 - - Virus Protein Vpr http://www.ncbi.nlm.nih.gov/gene/155807 Downregulation Luciferase reporter, immunofluorescence, RT-PCR. 21133815 It was also noted further that HIV miR-H1 downregulated expression of the cellular miRNA miR149, which is considered to target the Vpr gene encoded by HIV-1. HVID00011901 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-150(miR-150) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000479 CD4+ T cells - Virus Protein rev(Rev) http://www.ncbi.nlm.nih.gov/gene/155908 Downregulation Synthesis of short interfering RNAs and microRNA inhibitors, Plasmid construction, Alu-PCR, Real-time reverse transcription PCR detection, Flow cytometric analysis, Prediction of microRNA-binding sites, MicroRNA array analysis, Transfection, Isolation and culture of primary CD4+ T cells. 17906637 We have found that the 3'ends of HIV-1 messenger RNAs are targeted by a cluster of cellular miRNAs including miR-28, miR-125b, miR-150, miR-223 and miR-382, which are enriched in resting CD4+ T cells as compared to activated CD4+ T cells.It is known that every spliced or unspliced HIV-1 mRNA, with the exception of Nef-encoding mRNA, contains the 1.2-kb fragment we used (or a portion of it) in its 3'UTR25 . Thus, these cellular miRNAs, which bind the 1.2-kb fragment of the HIV-1 RNA 3'end, can inhibit the translation of almost all HIV-1-encoded proteins-including Tat and Rev, which are key in the transcription and translocation of viral RNA. HVID00011902 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-150(miR-150) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000479 CD4+ T cells - Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 Downregulation Synthesis of short interfering RNAs and microRNA inhibitors, Plasmid construction, Alu-PCR, Real-time reverse transcription PCR detection, Flow cytometric analysis, Prediction of microRNA-binding sites, MicroRNA array analysis, Transfection, Isolation and culture of primary CD4+ T cells. 17906637 We have found that the 3'ends of HIV-1 messenger RNAs are targeted by a cluster of cellular miRNAs including miR-28, miR-125b, miR-150, miR-223 and miR-382, which are enriched in resting CD4+ T cells as compared to activated CD4+ T cells.It is known that every spliced or unspliced HIV-1 mRNA, with the exception of Nef-encoding mRNA, contains the 1.2-kb fragment we used (or a portion of it) in its 3'UTR25 . Thus, these cellular miRNAs, which bind the 1.2-kb fragment of the HIV-1 RNA 3'end, can inhibit the translation of almost all HIV-1-encoded proteins-including Tat and Rev, which are key in the transcription and translocation of viral RNA. HVID00011903 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-155(microRNA-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000681 CD4(+)CD8(-) PBMCs Downregulation Virus Protein Nef http://www.ncbi.nlm.nih.gov/gene/156110 - Dual Luciferase reporter assays, Immunobloting, HIV sequence search and alignment, Cell cycle analysis, northern blot. 22080513 we find that several host microRNAs are significantly up- or downregulated around the time HIV-1 infection peaks in vitro.While microRNA-223 levels were significantly enriched in HIV-1-infected CD4+CD8PBMCs,microRNA-29a/b, microRNA-155 and microRNA-21 levels were significantly reduced.Based on the potential for microRNA binding sites in a conserved sequence of the Nef-3'-LTR, several host microRNAs potentially could affect HIV-1 gene expression.Among those microRNAs, the microRNA-29 family has seed complementarity in the HIV-1 3'-UTR, but the potential suppressive effect of microRNA-29 on HIV-1 is severely blocked by the secondary structure of the target region. HVID00011904 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-17(hsa-miR-17) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000071 - Downregulation Virus Protein KAT4B(PCAF) http://www.ncbi.nlm.nih.gov/gene/8850 Upregulation Hybridization and analysis, Reverse transcription and real-time PCR, Microarray probes, infection and flow cytometry, Transfection. 21569500 Two members of the hsa-miR-17/92 cluster, hsa-miR-17-5p and hsa-miR-20a, target the mRNA of the PCAF cofactor of Tat trans-activation. Our results and published microarrays agree in downregulation of these miRNA by HIV-1 . Their perturbation in HIV-1 infection is near the 2-fold cutoff and sensitive, and specific measurement of the expression changes by RT-qPCR is warranted. HVID00011905 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-20a(hsa-miR-20a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000076 - Downregulation Virus Protein KAT5B(PCAF) http://www.ncbi.nlm.nih.gov/gene/8850 Upregulation Infection and flow cytometry, TransfectionMicroarray probes, hybridization and analysis, Reverse transcription and real-time PCR. 21569500 Two members of the hsa-miR-17/92 cluster, hsa-miR-17-5p and hsa-miR-20a, target the mRNA of the PCAF cofactor of Tat trans-activation. Our results and published microarrays agree in downregulation of these miRNA by HIV-1 . Their perturbation in HIV-1 infection is near the 2-fold cutoff and sensitive, and specific measurement of the expression changes by RT-qPCR is warranted. HVID00011906 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-21(microRNA-21) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000077 CD4(+)CD8(-) PBMCs Downregulation Virus Protein Nef http://www.ncbi.nlm.nih.gov/gene/156110 - Dual Luciferase reporter assays, Immunobloting, HIV sequence search and alignment, Cell cycle analysis, northern blot. 22080513 we find that several host microRNAs are significantly up- or downregulated around the time HIV-1 infection peaks in vitro.While microRNA-223 levels were significantly enriched in HIV-1-infected CD4+CD8PBMCs,microRNA-29a/b, microRNA-155 and microRNA-21 levels were significantly reduced.Based on the potential for microRNA binding sites in a conserved sequence of the Nef-3'-LTR, several host microRNAs potentially could affect HIV-1 gene expression.Among those microRNAs, the microRNA-29 family has seed complementarity in the HIV-1 3'-UTR, but the potential suppressive effect of microRNA-29 on HIV-1 is severely blocked by the secondary structure of the target region. HVID00011907 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-223(miR-223) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000300 CD4+ T cells - Virus Protein rev(Rev) http://www.ncbi.nlm.nih.gov/gene/155908 Downregulation Synthesis of short interfering RNAs and microRNA inhibitors, Plasmid construction, Alu-PCR, Real-time reverse transcription PCR detection, Flow cytometric analysis, Prediction of microRNA-binding sites, MicroRNA array analysis, Transfection, Isolation and culture of primary CD4+ T cells. 17906637 We have found that the 3'ends of HIV-1 messenger RNAs are targeted by a cluster of cellular miRNAs including miR-28, miR-125b, miR-150, miR-223 and miR-382, which are enriched in resting CD4+ T cells as compared to activated CD4+ T cells.It is known that every spliced or unspliced HIV-1 mRNA, with the exception of Nef-encoding mRNA, contains the 1.2-kb fragment we used (or a portion of it) in its 3'UTR25 . Thus, these cellular miRNAs, which bind the 1.2-kb fragment of the HIV-1 RNA 3'end, can inhibit the translation of almost all HIV-1-encoded proteins-including Tat and Rev, which are key in the transcription and translocation of viral RNA. HVID00011908 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-223(miR-223) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000300 CD4+ T cells - Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 Downregulation Synthesis of short interfering RNAs and microRNA inhibitors, Plasmid construction, Alu-PCR, Real-time reverse transcription PCR detection, Flow cytometric analysis, Prediction of microRNA-binding sites, MicroRNA array analysis, Transfection, Isolation and culture of primary CD4+ T cells. 17906637 We have found that the 3'ends of HIV-1 messenger RNAs are targeted by a cluster of cellular miRNAs including miR-28, miR-125b, miR-150, miR-223 and miR-382, which are enriched in resting CD4+ T cells as compared to activated CD4+ T cells.It is known that every spliced or unspliced HIV-1 mRNA, with the exception of Nef-encoding mRNA, contains the 1.2-kb fragment we used (or a portion of it) in its 3'UTR25 . Thus, these cellular miRNAs, which bind the 1.2-kb fragment of the HIV-1 RNA 3'end, can inhibit the translation of almost all HIV-1-encoded proteins-including Tat and Rev, which are key in the transcription and translocation of viral RNA. HVID00011909 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-223(miR-223) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000300 CD4+ T lymphocytes Upregulation Virus Protein Nef http://www.ncbi.nlm.nih.gov/gene/156110 - Synthesis of short interfering RNAs and microRNA inhibitors, Plasmid construction, Alu-PCR, Real-time reverse transcription PCR detection, Flow cytometric analysis, Prediction of microRNA-binding sites, MicroRNA array analysis, Transfection, Isolation and culture of primary CD4+ T cells. 21862142 They concluded that several host miRNAs (miR-125b, miR-150, miR-28, miR-223, and miR-382), which are highly expressed in resting CD4+ T lymphocytes, may target the Nef/3'LTR region and contribute to HIV-1 latency. Specific antagomirs (anti-micro RNA antisense) against these miRNAs substantially increased HIV-1 protein translation in resting CD4 cells. HVID00011910 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-223(microRNA-223) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000300 CD4(+)CD8(-) PBMCs Upregulation Virus Protein Nef http://www.ncbi.nlm.nih.gov/gene/156110 - Dual Luciferase reporter assays, Immunobloting, HIV sequence search and alignment, Cell cycle analysis, northern blot. 22080513 we find that several host microRNAs are significantly up- or downregulated around the time HIV-1 infection peaks in vitro.While microRNA-223 levels were significantly enriched in HIV-1-infected CD4+CD8PBMCs,microRNA-29a/b, microRNA-155 and microRNA-21 levels were significantly reduced.Based on the potential for microRNA binding sites in a conserved sequence of the Nef-3'-LTR, several host microRNAs potentially could affect HIV-1 gene expression.Among those microRNAs, the microRNA-29 family has seed complementarity in the HIV-1 3'-UTR, but the potential suppressive effect of microRNA-29 on HIV-1 is severely blocked by the secondary structure of the target region. HVID00011911 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-28(miR-28) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000086 CD4+ T cells - Virus Protein rev(Rev) http://www.ncbi.nlm.nih.gov/gene/155908 Downregulation Alu-PCR, Real-time reverse transcription PCR detection, Flow cytometric analysis, MicroRNA array analysis, Transfection. 17906637 We have found that the 3'ends of HIV-1 messenger RNAs are targeted by a cluster of cellular miRNAs including miR-28, miR-125b, miR-150, miR-223 and miR-382, which are enriched in resting CD4+ T cells as compared to activated CD4+ T cells.It is known that every spliced or unspliced HIV-1 mRNA, with the exception of Nef-encoding mRNA, contains the 1.2-kb fragment we used (or a portion of it) in its 3'UTR25 . Thus, these cellular miRNAs, which bind the 1.2-kb fragment of the HIV-1 RNA 3'end, can inhibit the translation of almost all HIV-1-encoded proteins-including Tat and Rev, which are key in the transcription and translocation of viral RNA. HVID00011912 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-28(miR-28) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000086 CD4+ T cells - Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 Downregulation Alu-PCR, Real-time reverse transcription PCR detection, Flow cytometric analysis, MicroRNA array analysis, Transfection. 17906637 We have found that the 3'ends of HIV-1 messenger RNAs are targeted by a cluster of cellular miRNAs including miR-28, miR-125b, miR-150, miR-223 and miR-382, which are enriched in resting CD4+ T cells as compared to activated CD4+ T cells. It is known that every spliced or unspliced HIV-1 mRNA, with the exception of Nef-encoding mRNA, contains the 1.2-kb fragment we used (or a portion of it) in its 3'UTR25 . Thus, these cellular miRNAs, which bind the 1.2-kb fragment of the HIV-1 RNA 3'end, can inhibit the translation of almost all HIV-1-encoded proteins-including Tat and Rev, which are key in the transcription and translocation of viral RNA. HVID00011913 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-29a(hsa-miR-29a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000087 CD4+ T cells - Virus mRNA nef(Nef) http://www.ncbi.nlm.nih.gov/gene/156110 Downregulation Real-time reverse transcription PCR(RT-PCR), Reporter assay. 22936931 Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions. Table 2 List of published cellular microRNAs and their target HIV-2 and cellular gene products.Transcriptional control is vital to the HIV- 1 proliferation, thus determining microRNA interactions among host transcription factors and regulators is a necessity. HVID00011914 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-29a(hsa-miR29a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000087 HeLa cell line Downregulation Virus Protein nef(Nef) http://www.ncbi.nlm.nih.gov/gene/156110 Downregulation Trizol method, PCR amplification, Northern blotting, Single cycle replication studies, Transfection and Reporter assay, Primer extension. 19102781 Here we report the functionality of predicted miR-29a target site in the HIV-1 nef gene.Our results show that the cellular miRNA hsa-miR29a downregulates the expression of Nef protein and interferes with HIV-1 replication. HVID00011915 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-29a(miR-29a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000087 Jurkat cells - Virus Protein Nef http://www.ncbi.nlm.nih.gov/gene/156110 Downregulation Transfection and Reporter assay. 23043098 miRNAs can modulate HIV replication in two ways: directly targeting HIV RNA or targeting the mRNAs that encode host cell factors relevant to HIV replication.These investigators confirmed later that one of the five identified miRNAs (miR-29a) inhibited nef expression, leading to repressed HIV replication in Jurkat cells. HVID00011916 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-29a(microRNA-29a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000087 CD4(+)CD8(-) PBMCs Downregulation Virus Protein Nef http://www.ncbi.nlm.nih.gov/gene/156110 - Dual Luciferase reporter assays, Immunobloting, HIV sequence search and alignment, Cell cycle analysis, northern blot. 22080513 we find that several host microRNAs are significantly up- or downregulated around the time HIV-1 infection peaks in vitro.While microRNA-223 levels were significantly enriched in HIV-1-infected CD4+CD8PBMCs,microRNA-29a/b, microRNA-155 and microRNA-21 levels were significantly reduced.Based on the potential for microRNA binding sites in a conserved sequence of the Nef-3'-LTR, several host microRNAs potentially could affect HIV-1 gene expression.Among those microRNAs, the microRNA-29 family has seed complementarity in the HIV-1 3'-UTR, but the potential suppressive effect of microRNA-29 on HIV-1 is severely blocked by the secondary structure of the target region. HVID00011917 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-29b(hsa-miR29b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000105 HEK293T cells Downregulation Virus Protein nef(Nef) http://www.ncbi.nlm.nih.gov/gene/156110 Downregulation Trizol method, PCR amplification, Northern blotting, Single cycle replication studies, Transfection and Reporter assay, Primer extension. 19102781 Our results show that the cellular miRNA hsa-miR29a downregulates the expression of Nef protein and interferes with HIV-1 replication. HVID00011918 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-324-5p(miR-324-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000761 - - Virus Protein Vif http://www.ncbi.nlm.nih.gov/gene/155459 - - 21786074 Targets vif.Table 1 Functions of cellular miRNAs identified in HIV.Table 1 summarizes the list of cellular miRNAs identified in relation to HIV/AIDS, the functions of which are discussed in this review. HVID00011919 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-378 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 - - Virus Protein env http://www.ncbi.nlm.nih.gov/gene/155971 - MicroRNA microarray, consensus scoring approach. 16236258 Targets for human encoded microRNAs in HIV genes. While hsa-mir-29a and 29b target the nef gene, hsa-mir-149 targets the vpr gene, hsa-mir-378 targets env, and hsa-mir-324-5p targets the vif gene. HVID00011920 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-382(miR-382) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000790 CD4+ T lymphocytes Upregulation Virus Protein Nef http://www.ncbi.nlm.nih.gov/gene/156110 - Synthesis of short interfering RNAs and microRNA inhibitors, Plasmid construction, Alu-PCR, Real-time reverse transcription PCR detection, Flow cytometric analysis, Prediction of microRNA-binding sites, MicroRNA array analysis, Transfection, Isolation and culture of primary CD4+ T cells. 21862142 They concluded that several host miRNAs (miR-125b, miR-150, miR-28, miR-223, and miR-382), which are highly expressed in resting CD4+ T lymphocytes, may target the Nef/3'LTR region and contribute to HIV-1 latency. Specific antagomirs (anti-micro RNA antisense) against these miRNAs substantially increased HIV-1 protein translation in resting CD4 cells. HVID00011921 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-382(miR-382) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000790 CD4+ T lymphocytes Upregulation Virus Protein rev(Rev) http://www.ncbi.nlm.nih.gov/gene/155908 - Synthesis of short interfering RNAs and microRNA inhibitors, Plasmid construction, Alu-PCR, Real-time reverse transcription PCR detection, Flow cytometric analysis, Prediction of microRNA-binding sites, MicroRNA array analysis, Transfection, Isolation and culture of primary CD4+ T cells. 17906637 We have found that the 3'ends of HIV-1 messenger RNAs are targeted by a cluster of cellular miRNAs including miR-28, miR-125b, miR-150, miR-223 and miR-382, which are enriched in resting CD4+ T cells as compared to activated CD4+ T cells.It is known that every spliced or unspliced HIV-1 mRNA, with the exception of Nef-encoding mRNA, contains the 1.2-kb fragment we used (or a portion of it) in its 3'UTR25 . Thus, these cellular miRNAs, which bind the 1.2-kb fragment of the HIV-1 RNA 3'end, can inhibit the translation of almost all HIV-1-encoded proteins-including Tat and Rev, which are key in the transcription and translocation of viral RNA. HVID00011922 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-382(miR-382) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000790 CD4+ T lymphocytes Upregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - Synthesis of short interfering RNAs and microRNA inhibitors, Plasmid construction, Alu-PCR, Real-time reverse transcription PCR detection, Flow cytometric analysis, Prediction of microRNA-binding sites, MicroRNA array analysis, Transfection, Isolation and culture of primary CD4+ T cells. 17906637 We have found that the 3'ends of HIV-1 messenger RNAs are targeted by a cluster of cellular miRNAs including miR-28, miR-125b, miR-150, miR-223 and miR-382, which are enriched in resting CD4+ T cells as compared to activated CD4+ T cells.It is known that every spliced or unspliced HIV-1 mRNA, with the exception of Nef-encoding mRNA, contains the 1.2-kb fragment we used (or a portion of it) in its 3'UTR25 . Thus, these cellular miRNAs, which bind the 1.2-kb fragment of the HIV-1 RNA 3'end, can inhibit the translation of almost all HIV-1-encoded proteins-including Tat and Rev, which are key in the transcription and translocation of viral RNA. HVID00011923 Human immunodeficiency virus 1(HIV-1) Homo sapiens Host miRNA hsa-mir-92a(hsa-miR-92) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000093 - Downregulation Virus Protein KAT3B(PCAF) http://www.ncbi.nlm.nih.gov/gene/8850 Upregulation Hybridization and analysis, Reverse transcription and real-time PCR, Microarray probes, infection and flow cytometry, Transfection. 21569500 Two members of the hsa-miR-17/92 cluster, hsa-miR-17-5p and hsa-miR-20a, target the mRNA of the PCAF cofactor of Tat trans-activation. Our results and published microarrays agree in downregulation of these miRNA by HIV-1 . Their perturbation in HIV-1 infection is near the 2-fold cutoff and sensitive, and specific measurement of the expression changes by RT-qPCR is warranted. HVID00011924 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-let-7b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000829 - Downregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - Quantitative RT-PCR, Immunohistochemistry, MicroRNA microarray, microRNA functional analysis, MicroRNA gene targets prediction, Western blots, Statistical analysis. 18381601 These are designated 128a, 128b, 100, 99a, 30b, 30c, let-7c, let-7f, let-7b, let-7e, 125a, 125b, 191, 181a, and 9. A group of six microRNAs (374, 128a, 128b, 100, 25, and 99a) was upregulated in Tat-treated samples (mean fold change from 4.4 to 1.5; P-value <0.01). The presence of Tat in neurons also determined a downregulation of seven microRNAs: let-7e, 298, let-7f, let-7c, let-7b, 320, and 214. The expression pattern of a third group of microRNAs (125a, 92, 30c, 99b, 125b, 181a, 191, and 9) was not changed by Tat-treatment. HVID00011925 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-let-7b(let-7b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000829 rat primary cortical neurons Downregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - - 21786074 Eletto and colleagues reported that a group of six miRNAs (374, 128a, 128b, 100, 25, and 99a) were upregulated and seven miRNAs (let-7e, 298, let-7f, let-7c, let-7b, 320, and 214) were downregulated by Tat in rat primary cortical neurons. Among these, miR-128a has been found to be enriched in the brain, preferentially in the mature neurons. HVID00011926 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-let-7c-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000830 - Downregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - Quantitative RT-PCR, Immunohistochemistry, MicroRNA microarray, microRNA functional analysis, MicroRNA gene targets prediction, Western blots, Statistical analysis. 18381601 These are designated 128a, 128b, 100, 99a, 30b, 30c, let-7c, let-7f, let-7b, let-7e, 125a, 125b, 191, 181a, and 9. A group of six microRNAs (374, 128a, 128b, 100, 25, and 99a) was upregulated in Tat-treated samples (mean fold change from 4.4 to 1.5; P-value <0.01). The presence of Tat in neurons also determined a downregulation of seven microRNAs: let-7e, 298, let-7f, let-7c, let-7b, 320, and 214. The expression pattern of a third group of microRNAs (125a, 92, 30c, 99b, 125b, 181a, 191, and 9) was not changed by Tat-treatment. HVID00011927 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-let-7c-1(let-7c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000830 rat primary cortical neurons Downregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - - 21786074 Eletto and colleagues reported that a group of six miRNAs (374, 128a, 128b, 100, 25, and 99a) were upregulated and seven miRNAs (let-7e, 298, let-7f, let-7c, let-7b, 320, and 214) were downregulated by Tat in rat primary cortical neurons. Among these, miR-128a has been found to be enriched in the brain, preferentially in the mature neurons. HVID00011928 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-let-7e http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000832 - Downregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - Quantitative RT-PCR, Immunohistochemistry, MicroRNA microarray, microRNA functional analysis, MicroRNA gene targets prediction, Western blots, Statistical analysis. 18381601 These are designated 128a, 128b, 100, 99a, 30b, 30c, let-7c, let-7f, let-7b, let-7e, 125a, 125b, 191, 181a, and 9. A group of six microRNAs (374, 128a, 128b, 100, 25, and 99a) was upregulated in Tat-treated samples (mean fold change from 4.4 to 1.5; P-value <0.01). The presence of Tat in neurons also determined a downregulation of seven microRNAs: let-7e, 298, let-7f, let-7c, let-7b, 320, and 214. The expression pattern of a third group of microRNAs (125a, 92, 30c, 99b, 125b, 181a, 191, and 9) was not changed by Tat-treatment. HVID00011929 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-let-7e(let-7e) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000832 rat primary cortical neurons Downregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - - 21786074 Eletto and colleagues reported that a group of six miRNAs (374, 128a, 128b, 100, 25, and 99a) were upregulated and seven miRNAs (let-7e, 298, let-7f, let-7c, let-7b, 320, and 214) were downregulated by Tat in rat primary cortical neurons. Among these, miR-128a has been found to be enriched in the brain, preferentially in the mature neurons. HVID00011930 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-let-7f-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000833 - Downregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - Quantitative RT-PCR, Immunohistochemistry, MicroRNA microarray, microRNA functional analysis, MicroRNA gene targets prediction, Western blots, Statistical analysis. 18381601 These are designated 128a, 128b, 100, 99a, 30b, 30c, let-7c, let-7f, let-7b, let-7e, 125a, 125b, 191, 181a, and 9. A group of six microRNAs (374, 128a, 128b, 100, 25, and 99a) was upregulated in Tat-treated samples (mean fold change from 4.4 to 1.5; P-value <0.01). The presence of Tat in neurons also determined a downregulation of seven microRNAs: let-7e, 298, let-7f, let-7c, let-7b, 320, and 214. The expression pattern of a third group of microRNAs (125a, 92, 30c, 99b, 125b, 181a, 191, and 9) was not changed by Tat-treatment. HVID00011931 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-let-7f-1(let-7f) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000833 rat primary cortical neurons Downregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - - 21786074 Eletto and colleagues reported that a group of six miRNAs (374, 128a, 128b, 100, 25, and 99a) were upregulated and seven miRNAs (let-7e, 298, let-7f, let-7c, let-7b, 320, and 214) were downregulated by Tat in rat primary cortical neurons. Among these, miR-128a has been found to be enriched in the brain, preferentially in the mature neurons. HVID00011932 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-mir-100 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000885 - Upregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - Quantitative RT-PCR, Immunohistochemistry, MicroRNA microarray, microRNA functional analysis, MicroRNA gene targets prediction, Western blots, Statistical analysis. 18381601 These are designated 128a, 128b, 100, 99a, 30b, 30c, let-7c, let-7f, let-7b, let-7e, 125a, 125b, 191, 181a, and 9. A group of six microRNAs (374, 128a, 128b, 100, 25, and 99a) was upregulated in Tat-treated samples (mean fold change from 4.4 to 1.5; P-value <0.01). The presence of Tat in neurons also determined a downregulation of seven microRNAs: let-7e, 298, let-7f, let-7c, let-7b, 320, and 214. The expression pattern of a third group of microRNAs (125a, 92, 30c, 99b, 125b, 181a, 191, and 9) was not changed by Tat-treatment. HVID00011933 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-mir-100(miR-100) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000885 rat primary cortical neurons Upregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - - 21786074 Eletto and colleagues reported that a group of six miRNAs (374, 128a, 128b, 100, 25, and 99a) were upregulated and seven miRNAs (let-7e, 298, let-7f, let-7c, let-7b, 320, and 214) were downregulated by Tat in rat primary cortical neurons. Among these, miR-128a has been found to be enriched in the brain, preferentially in the mature neurons. HVID00011934 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-mir-128-1(miR-128a ) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000900 - Upregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - Quantitative RT-PCR, Immunohistochemistry, MicroRNA microarray, microRNA functional analysis, MicroRNA gene targets prediction, Western blots, Statistical analysis. 18381601 These are designated 128a, 128b, 100, 99a, 30b, 30c, let-7c, let-7f, let-7b, let-7e, 125a, 125b, 191, 181a, and 9. A group of six microRNAs (374, 128a, 128b, 100, 25, and 99a) was upregulated in Tat-treated samples (mean fold change from 4.4 to 1.5; P-value <0.01). The presence of Tat in neurons also determined a downregulation of seven microRNAs: let-7e, 298, let-7f, let-7c, let-7b, 320, and 214. The expression pattern of a third group of microRNAs (125a, 92, 30c, 99b, 125b, 181a, 191, and 9) was not changed by Tat-treatment. HVID00011935 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-mir-128-1(miR-128a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000900 rat primary cortical neurons Upregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - - 21786074 Eletto and colleagues reported that a group of six miRNAs (374, 128a, 128b, 100, 25, and 99a) were upregulated and seven miRNAs (let-7e, 298, let-7f, let-7c, let-7b, 320, and 214) were downregulated by Tat in rat primary cortical neurons. Among these, miR-128a has been found to be enriched in the brain, preferentially in the mature neurons. HVID00011936 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-mir-128-2(miR-128b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000901 - Upregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - Quantitative RT-PCR, Immunohistochemistry, MicroRNA microarray, microRNA functional analysis, MicroRNA gene targets prediction, Western blots, Statistical analysis. 18381601 These are designated 128a, 128b, 100, 99a, 30b, 30c, let-7c, let-7f, let-7b, let-7e, 125a, 125b, 191, 181a, and 9. A group of six microRNAs (374, 128a, 128b, 100, 25, and 99a) was upregulated in Tat-treated samples (mean fold change from 4.4 to 1.5; P-value <0.01). The presence of Tat in neurons also determined a downregulation of seven microRNAs: let-7e, 298, let-7f, let-7c, let-7b, 320, and 214. The expression pattern of a third group of microRNAs (125a, 92, 30c, 99b, 125b, 181a, 191, and 9) was not changed by Tat-treatment. HVID00011937 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-mir-128-2(miR-128b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000901 rat primary cortical neurons Upregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - - 21786074 Eletto and colleagues reported that a group of six miRNAs (374, 128a, 128b, 100, 25, and 99a) were upregulated and seven miRNAs (let-7e, 298, let-7f, let-7c, let-7b, 320, and 214) were downregulated by Tat in rat primary cortical neurons. Among these, miR-128a has been found to be enriched in the brain, preferentially in the mature neurons. HVID00011938 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-mir-214 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000954 - Downregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - Quantitative RT-PCR, Immunohistochemistry, MicroRNA microarray, microRNA functional analysis, MicroRNA gene targets prediction, Western blots, Statistical analysis. 18381601 These are designated 128a, 128b, 100, 99a, 30b, 30c, let-7c, let-7f, let-7b, let-7e, 125a, 125b, 191, 181a, and 9. A group of six microRNAs (374, 128a, 128b, 100, 25, and 99a) was upregulated in Tat-treated samples (mean fold change from 4.4 to 1.5; P-value <0.01). The presence of Tat in neurons also determined a downregulation of seven microRNAs: let-7e, 298, let-7f, let-7c, let-7b, 320, and 214. The expression pattern of a third group of microRNAs (125a, 92, 30c, 99b, 125b, 181a, 191, and 9) was not changed by Tat-treatment. HVID00011939 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-mir-214(miR-214) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000954 rat primary cortical neurons Downregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - - 21786074 Eletto and colleagues reported that a group of six miRNAs (374, 128a, 128b, 100, 25, and 99a) were upregulated and seven miRNAs (let-7e, 298, let-7f, let-7c, let-7b, 320, and 214) were downregulated by Tat in rat primary cortical neurons. Among these, miR-128a has been found to be enriched in the brain, preferentially in the mature neurons. HVID00011940 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-mir-25 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000856 - Upregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - Quantitative RT-PCR, Immunohistochemistry, MicroRNA microarray, microRNA functional analysis, MicroRNA gene targets prediction, Western blots, Statistical analysis. 18381601 These are designated 128a, 128b, 100, 99a, 30b, 30c, let-7c, let-7f, let-7b, let-7e, 125a, 125b, 191, 181a, and 9. A group of six microRNAs (374, 128a, 128b, 100, 25, and 99a) was upregulated in Tat-treated samples (mean fold change from 4.4 to 1.5; P-value <0.01). The presence of Tat in neurons also determined a downregulation of seven microRNAs: let-7e, 298, let-7f, let-7c, let-7b, 320, and 214. The expression pattern of a third group of microRNAs (125a, 92, 30c, 99b, 125b, 181a, 191, and 9) was not changed by Tat-treatment. HVID00011941 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-mir-25(miR-25) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000856 rat primary cortical neurons Upregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - - 21786074 Eletto and colleagues reported that a group of six miRNAs (374, 128a, 128b, 100, 25, and 99a) were upregulated and seven miRNAs (let-7e, 298, let-7f, let-7c, let-7b, 320, and 214) were downregulated by Tat in rat primary cortical neurons. Among these, miR-128a has been found to be enriched in the brain, preferentially in the mature neurons. HVID00011942 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-mir-298 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000969 - Downregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - Quantitative RT-PCR, Immunohistochemistry, MicroRNA microarray, microRNA functional analysis, MicroRNA gene targets prediction, Western blots, Statistical analysis. 18381601 These are designated 128a, 128b, 100, 99a, 30b, 30c, let-7c, let-7f, let-7b, let-7e, 125a, 125b, 191, 181a, and 9. A group of six microRNAs (374, 128a, 128b, 100, 25, and 99a) was upregulated in Tat-treated samples (mean fold change from 4.4 to 1.5; P-value <0.01). The presence of Tat in neurons also determined a downregulation of seven microRNAs: let-7e, 298, let-7f, let-7c, let-7b, 320, and 214. The expression pattern of a third group of microRNAs (125a, 92, 30c, 99b, 125b, 181a, 191, and 9) was not changed by Tat-treatment. HVID00011943 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-mir-298(miR-298) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000969 rat primary cortical neurons Downregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - - 21786074 Eletto and colleagues reported that a group of six miRNAs (374, 128a, 128b, 100, 25, and 99a) were upregulated and seven miRNAs (let-7e, 298, let-7f, let-7c, let-7b, 320, and 214) were downregulated by Tat in rat primary cortical neurons. Among these, miR-128a has been found to be enriched in the brain, preferentially in the mature neurons. HVID00011944 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-mir-320 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000972 - Downregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - Quantitative RT-PCR, Immunohistochemistry, MicroRNA microarray, microRNA functional analysis, MicroRNA gene targets prediction, Western blots, Statistical analysis. 18381601 These are designated 128a, 128b, 100, 99a, 30b, 30c, let-7c, let-7f, let-7b, let-7e, 125a, 125b, 191, 181a, and 9. A group of six microRNAs (374, 128a, 128b, 100, 25, and 99a) was upregulated in Tat-treated samples (mean fold change from 4.4 to 1.5; P-value <0.01). The presence of Tat in neurons also determined a downregulation of seven microRNAs: let-7e, 298, let-7f, let-7c, let-7b, 320, and 214. The expression pattern of a third group of microRNAs (125a, 92, 30c, 99b, 125b, 181a, 191, and 9) was not changed by Tat-treatment. HVID00011945 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-mir-320(miR-320) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000972 rat primary cortical neurons Downregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - - 21786074 Eletto and colleagues reported that a group of six miRNAs (374, 128a, 128b, 100, 25, and 99a) were upregulated and seven miRNAs (let-7e, 298, let-7f, let-7c, let-7b, 320, and 214) were downregulated by Tat in rat primary cortical neurons. Among these, miR-128a has been found to be enriched in the brain, preferentially in the mature neurons. HVID00011946 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-mir-374 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003552 - Upregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - Quantitative RT-PCR, Immunohistochemistry, MicroRNA microarray, microRNA functional analysis, MicroRNA gene targets prediction, Western blots, Statistical analysis. 18381601 These are designated 128a, 128b, 100, 99a, 30b, 30c, let-7c, let-7f, let-7b, let-7e, 125a, 125b, 191, 181a, and 9. A group of six microRNAs (374, 128a, 128b, 100, 25, and 99a) was upregulated in Tat-treated samples (mean fold change from 4.4 to 1.5; P-value <0.01). The presence of Tat in neurons also determined a downregulation of seven microRNAs: let-7e, 298, let-7f, let-7c, let-7b, 320, and 214. The expression pattern of a third group of microRNAs (125a, 92, 30c, 99b, 125b, 181a, 191, and 9) was not changed by Tat-treatment. HVID00011947 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-mir-374(miR-374) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003552 rat primary cortical neurons Upregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - - 21786074 Eletto and colleagues reported that a group of six miRNAs (374, 128a, 128b, 100, 25, and 99a) were upregulated and seven miRNAs (let-7e, 298, let-7f, let-7c, let-7b, 320, and 214) were downregulated by Tat in rat primary cortical neurons. Among these, miR-128a has been found to be enriched in the brain, preferentially in the mature neurons. HVID00011948 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-mir-99a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000883 - Upregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - Quantitative RT-PCR, Immunohistochemistry, MicroRNA microarray, microRNA functional analysis, MicroRNA gene targets prediction, Western blots, Statistical analysis. 18381601 These are designated 128a, 128b, 100, 99a, 30b, 30c, let-7c, let-7f, let-7b, let-7e, 125a, 125b, 191, 181a, and 9. A group of six microRNAs (374, 128a, 128b, 100, 25, and 99a) was upregulated in Tat-treated samples (mean fold change from 4.4 to 1.5; P-value <0.01). The presence of Tat in neurons also determined a downregulation of seven microRNAs: let-7e, 298, let-7f, let-7c, let-7b, 320, and 214. The expression pattern of a third group of microRNAs (125a, 92, 30c, 99b, 125b, 181a, 191, and 9) was not changed by Tat-treatment. HVID00011949 Human immunodeficiency virus 1(HIV-1) Rattus norvegicus Host miRNA rno-mir-99a(miR-99a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000883 rat primary cortical neurons Upregulation Virus Protein tat(Tat) http://www.ncbi.nlm.nih.gov/gene/155871 - - 21786074 Eletto and colleagues reported that a group of six miRNAs (374, 128a, 128b, 100, 25, and 99a) were upregulated and seven miRNAs (let-7e, 298, let-7f, let-7c, let-7b, 320, and 214) were downregulated by Tat in rat primary cortical neurons. Among these, miR-128a has been found to be enriched in the brain, preferentially in the mature neurons. HVID00011950 Human papillomavirus 16(HPV16) Homo sapiens Host miRNA hsa-mir-203a(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000283 - Upregulation Virus Protein E6 http://www.ncbi.nlm.nih.gov/gene/1489078 Downregulation Western blot analysis, microRNA real-time PCR, Reverse transcription-PCR (RT-PCR) analysis, Northern blotting for microRNAs, Immunofluorescence staining and analysis. 20702634 We report that proliferation of HFKs is dependent on the level of miR-203 expression and that overexpression of miR-203 can reduce overproliferation in E6/E7-expressing and p53i HFKs. In summary, these results indicate that expression of miR-203 is dependent on p53, which may explain how expression of HPV16 E6 can disrupt the balance between proliferation and differentiation, as well as the response to DNA damage, in keratinocytes. HVID00011951 Human papillomavirus 16(HPV16) Homo sapiens Host miRNA hsa-mir-203a(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000283 - Upregulation Virus Protein E7 http://www.ncbi.nlm.nih.gov/gene/1489079 Downregulation Western blot analysis, microRNA real-time PCR, Reverse transcription-PCR (RT-PCR) analysis, Northern blotting for microRNAs, Immunofluorescence staining and analysis. 20702634 We report that proliferation of HFKs is dependent on the level of miR-203 expression and that overexpression of miR-203 can reduce overproliferation in E6/E7-expressing and p53i HFKs. In summary, these results indicate that expression of miR-203 is dependent on p53, which may explain how expression of HPV16 E6 can disrupt the balance between proliferation and differentiation, as well as the response to DNA damage, in keratinocytes. HVID00011952 Human papillomavirus 16(HPV16) Homo sapiens Host miRNA hsa-mir-205(miR-205) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000285 HFKs Downregulation Virus Protein E6 http://www.ncbi.nlm.nih.gov/gene/1489078 - Immunofluorescent analysis,Luciferase reporter assay,Western blot analysis,RT-PCR analysis,microRNA real-time PCR,Northern blotting for microRNAs. 24314651 We investigated how expression of Human Papilloma Virus Type-16 (HPV16) onco-proteins E6 and E7 affected expression of miR-24 and miR-205 during proliferation and differentiation of HFKs. We show that the induction of both miR-24 and miR-205 observed during differentiation of HFKs is lost in HFKs expressing E6 and E7. HVID00011953 Human papillomavirus 16(HPV16) Homo sapiens Host miRNA hsa-mir-205(miR-205) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000285 HFKs Downregulation Virus Protein E7 http://www.ncbi.nlm.nih.gov/gene/1489079 - Immunofluorescent analysis,Luciferase reporter assay,Western blot analysis,RT-PCR analysis,microRNA real-time PCR,Northern blotting for microRNAs. 24314651 We investigated how expression of Human Papilloma Virus Type-16 (HPV16) onco-proteins E6 and E7 affected expression of miR-24 and miR-205 during proliferation and differentiation of HFKs. We show that the induction of both miR-24 and miR-205 observed during differentiation of HFKs is lost in HFKs expressing E6 and E7. HVID00011954 Human papillomavirus 16(HPV16) Homo sapiens Host miRNA hsa-mir-24(miR-24) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000080 HFKs Downregulation Virus Protein E6 http://www.ncbi.nlm.nih.gov/gene/1489078 - Immunofluorescent analysis,Luciferase reporter assay,Western blot analysis,RT-PCR analysis,microRNA real-time PCR,Northern blotting for microRNAs. 24314651 We investigated how expression of Human Papilloma Virus Type-16 (HPV16) onco-proteins E6 and E7 affected expression of miR-24 and miR-205 during proliferation and differentiation of HFKs. We show that the induction of both miR-24 and miR-205 observed during differentiation of HFKs is lost in HFKs expressing E6 and E7. HVID00011955 Human papillomavirus 16(HPV16) Homo sapiens Host miRNA hsa-mir-24(miR-24) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000080 HFKs Downregulation Virus Protein E7 http://www.ncbi.nlm.nih.gov/gene/1489079 - Immunofluorescent analysis,Luciferase reporter assay,Western blot analysis,RT-PCR analysis,microRNA real-time PCR,Northern blotting for microRNAs. 24314651 We investigated how expression of Human Papilloma Virus Type-16 (HPV16) onco-proteins E6 and E7 affected expression of miR-24 and miR-205 during proliferation and differentiation of HFKs. We show that the induction of both miR-24 and miR-205 observed during differentiation of HFKs is lost in HFKs expressing E6 and E7. HVID00011956 Human papillomavirus 16(HPV16) Homo sapiens Host miRNA hsa-mir-34a(miR-34a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000268 Cervical Downregulation Virus Protein E6 http://www.ncbi.nlm.nih.gov/gene/1489078 - Retrovirus infection, Immunohistochemistry and microscopy, miRNA ligation assay, Northern blot analysis, and organotypic cultures, RNAi interference, Primary human keratinocytes, Western blot analysis, Cell transfection, Flow cytometry. 19258450 The reduction of miR-34a expression in organotypic tissues derived from HPV-containing primary human keratinocytes correlates with the early productive phase and is attributed to the expression of viral E6, which destabilizes the tumor suppressor p53, a known miR-34a transactivator. HVID00011957 Human papillomavirus(HPV) Homo sapiens Host LncRNA ASncmtRNA-1 # HFK698 cells Downregulation Virus Protein E2 http://www.ncbi.nlm.nih.gov/gene/13887826 Downregulation RT-PCR Amplification/In Situ Hybridization(ISH). 22539350 Here we show that immortalization of HFK with HPV-16 or 18 causes down-regulation of the ASncmtRNAs and induces the expression of a new sense transcript named SncmtRNA-2. Transduction of HFK with both E6 and E7 is sufficient to induce expression of SncmtRNA-2. Moreover, E2 oncogene is involved in down-regulation of the ASncmtRNAs. Knockdown of E2 in immortalized cells reestablishes in a reversible manner the expression of the ASncmtRNAs, suggesting that endogenous cellular factors(s) could play functions analogous to E2 during non-HPV-induced oncogenesis.ASncmtRNAs Are Down-regulated in HPV-immortalized Cells As seen in Fig. 1. HVID00011958 Human papillomavirus(HPV) Homo sapiens Host LncRNA ASncmtRNA-2 # HFK698 cells Downregulation Virus Protein E2 http://www.ncbi.nlm.nih.gov/gene/13887826 Downregulation RT-PCR Amplification/In Situ Hybridization(ISH). 22539350 Here we show that immortalization of HFK with HPV-16 or 18 causes down-regulation of the ASncmtRNAs and induces the expression of a new sense transcript named SncmtRNA-2. Transduction of HFK with both E6 and E7 is sufficient to induce expression of SncmtRNA-2. Moreover, E2 oncogene is involved in down-regulation of the ASncmtRNAs. Knockdown of E2 in immortalized cells reestablishes in a reversible manner the expression of the ASncmtRNAs, suggesting that endogenous cellular factors(s) could play functions analogous to E2 during non-HPV-induced oncogenesis.ASncmtRNAs Are Down-regulated in HPV-immortalized Cells As seen in Fig. 1. HVID00011959 Human papillomavirus(HPV) Homo sapiens Host miRNA hsa-mir-100(miR-100) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000102 organotypic raft cultures of foreskin and vaginal keratinocytes Downregulation Virus Protein E6 http://www.ncbi.nlm.nih.gov/gene/1489078 - RT-qPCR. 24591631 Interestingly, miR-22, miR-27a,miR-29a, and miR-100 were all moderately down-regulated by either E6 or E7, with miR-22 and miR-27a being slightly more susceptible to E7 than to E6. HVID00011960 Human papillomavirus(HPV) Homo sapiens Host miRNA hsa-mir-100(miR-100) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000102 organotypic raft cultures of foreskin and vaginal keratinocytes Downregulation Virus Protein E7 http://www.ncbi.nlm.nih.gov/gene/1489079 - RT-qPCR. 24591631 Interestingly, miR-22, miR-27a,miR-29a, and miR-100 were all moderately down-regulated by either E6 or E7, with miR-22 and miR-27a being slightly more susceptible to E7 than to E6. HVID00011961 Human papillomavirus(HPV) Homo sapiens Host miRNA hsa-mir-203a(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000283 Foreskin keratinocytes Downregulation Virus Protein E7 http://www.ncbi.nlm.nih.gov/gene/1489079 - QRT-PCR, Luciferase assay, Northern blot analysis, Western blot analysis, Southern blot analysis. 20219920 We show that the HPV E7 protein downregulates miR-203 expression upon differentiation, which may occur through the mitogen-activated protein(MAP) kinase/protein kinase C(PKC) pathway.One factor that negatively regulates proliferative capability upon differentiation is microRNA 203 (miR-203), which is expressed primarily in suprabasal epithelial cells. Although HPVs do not encode their own microRNAs (miRNAs), they modulate expression of cellular miRNAs to regulate the activities of cellular proteins. . HVID00011962 Human papillomavirus(HPV) Homo sapiens Host miRNA hsa-mir-203b(miR-203) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0017343 Foreskin keratinocytes Downregulation Virus Protein E7 http://www.ncbi.nlm.nih.gov/gene/1489079 - QRT-PCR, Luciferase assay, Northern blot analysis, Western blot analysis, Southern blot analysis. 20219920 We show that the HPV E7 protein downregulates miR-203 expression upon differentiation, which may occur through the mitogen-activated protein(MAP) kinase/protein kinase C(PKC) pathway.One factor that negatively regulates proliferative capability upon differentiation is microRNA 203 (miR-203), which is expressed primarily in suprabasal epithelial cells. Although HPVs do not encode their own microRNAs (miRNAs), they modulate expression of cellular miRNAs to regulate the activities of cellular proteins. . HVID00011963 Human papillomavirus(HPV) Homo sapiens Host miRNA hsa-mir-22(miR-22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000078 organotypic raft cultures of foreskin and vaginal keratinocytes Downregulation Virus Protein E6 http://www.ncbi.nlm.nih.gov/gene/1489078 - RT-qPCR. 24591631 Interestingly, miR-22, miR-27a,miR-29a, and miR-100 were all moderately down-regulated by either E6 or E7, with miR-22 and miR-27a being slightly more susceptible to E7 than to E6. HVID00011964 Human papillomavirus(HPV) Homo sapiens Host miRNA hsa-mir-22(miR-22) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000078 organotypic raft cultures of foreskin and vaginal keratinocytes Downregulation Virus Protein E7 http://www.ncbi.nlm.nih.gov/gene/1489079 - RT-qPCR. 24591631 Interestingly, miR-22, miR-27a,miR-29a, and miR-100 were all moderately down-regulated by either E6 or E7, with miR-22 and miR-27a being slightly more susceptible to E7 than to E6. HVID00011965 Human papillomavirus(HPV) Homo sapiens Host miRNA hsa-mir-25(miR-25) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000082 organotypic raft cultures of foreskin and vaginal keratinocytes Upregulation Virus Protein E7 http://www.ncbi.nlm.nih.gov/gene/1489079 - RT-qPCR. 24591631 As expected, E6 decreased the expression of miR-34a, whereas E7 did not. In contrast, HPV18 E7 significantly increased the expression of miR-25, whereas HPV18 E6 had no effect. HVID00011966 Human papillomavirus(HPV) Homo sapiens Host miRNA hsa-mir-27a(miR-27a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000085 organotypic raft cultures of foreskin and vaginal keratinocytes Downregulation Virus Protein E6 http://www.ncbi.nlm.nih.gov/gene/1489078 - RT-qPCR. 24591631 Interestingly, miR-22, miR-27a,miR-29a, and miR-100 were all moderately down-regulated by either E6 or E7, with miR-22 and miR-27a being slightly more susceptible to E7 than to E6. HVID00011967 Human papillomavirus(HPV) Homo sapiens Host miRNA hsa-mir-27a(miR-27a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000085 organotypic raft cultures of foreskin and vaginal keratinocytes Downregulation Virus Protein E7 http://www.ncbi.nlm.nih.gov/gene/1489079 - RT-qPCR. 24591631 Interestingly, miR-22, miR-27a,miR-29a, and miR-100 were all moderately down-regulated by either E6 or E7, with miR-22 and miR-27a being slightly more susceptible to E7 than to E6. HVID00011968 Human papillomavirus(HPV) Homo sapiens Host miRNA hsa-mir-29a(miR-29a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000087 organotypic raft cultures of foreskin and vaginal keratinocytes Downregulation Virus Protein E6 http://www.ncbi.nlm.nih.gov/gene/1489078 - RT-qPCR. 24591631 Interestingly, miR-22, miR-27a,miR-29a, and miR-100 were all moderately down-regulated by either E6 or E7, with miR-22 and miR-27a being slightly more susceptible to E7 than to E6. HVID00011969 Human papillomavirus(HPV) Homo sapiens Host miRNA hsa-mir-29a(miR-29a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000087 organotypic raft cultures of foreskin and vaginal keratinocytes Downregulation Virus Protein E7 http://www.ncbi.nlm.nih.gov/gene/1489079 - RT-qPCR. 24591631 Interestingly, miR-22, miR-27a,miR-29a, and miR-100 were all moderately down-regulated by either E6 or E7, with miR-22 and miR-27a being slightly more susceptible to E7 than to E6. HVID00011970 Human papillomavirus(HPV) Homo sapiens Host miRNA hsa-mir-34a(miR-34a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000268 organotypic raft cultures of foreskin and vaginal keratinocytes Downregulation Virus Protein E6 http://www.ncbi.nlm.nih.gov/gene/1489078 - RT-qPCR. 24591631 As expected, E6 decreased the expression of miR-34a, whereas E7 did not. In contrast, HPV18 E7 significantly increased the expression of miR-25, whereas HPV18 E6 had no effect. HVID00011971 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-let-7c(let-7c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000064 Lung epithelial cells Upregulation Virus Protein M1 http://www.ncbi.nlm.nih.gov/gene/956527 - Luciferase reporter. 22452878 Specifically, miR-let-7c was highly up-regulated in IV-infected A549 cells. PITA and miRanda database screening indicated that the let-7c seed sequence is a perfect complementary sequence match to the 3' untranslated region (UTR) of viral gene M1 (+) cRNA, but not to PB2 and PA. As detected by a luciferase reporter system, let-7c directly targeted the 3'-UTR of M1 (+) cRNA, but not PB2 and PA. HVID00011972 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-323a(miR-323) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000807 MDCK cells - Virus mRNA PB1 http://www.ncbi.nlm.nih.gov/gene/956534 Downregulation Luciferase assay, Real-time reverse transcription-PCR analysis, HA assay, Western blot assay, Fluorescence microscopy. 20554777 The results showed that miRNA 323 (miR-323), miR-491, and miR-654 inhibit replication of the H1N1 influenza A virus through binding to the PB1 gene. Moreover mutational analysis of the predicted miRNA binding sites showed that the three miRNAs bind to the same conserved region of the PB1 gene. Intriguingly, despite the fact that the miRNAs and PB1 mRNA binding sequences are not a perfect match, the miRNAs downregulate PB1 expression through mRNA degradation instead of translation repression. HVID00011973 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-491(miR-491) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003126 MDCK cells - Virus mRNA PB1 http://www.ncbi.nlm.nih.gov/gene/956534 Downregulation Luciferase assay, Real-time reverse transcription-PCR analysis, HA assay, Western blot assay, Fluorescence microscopy. 20554777 The results showed that miRNA 323 (miR-323), miR-491, and miR-654 inhibit replication of the H1N1 influenza A virus through binding to the PB1 gene. Moreover mutational analysis of the predicted miRNA binding sites showed that the three miRNAs bind to the same conserved region of the PB1 gene. Intriguingly, despite the fact that the miRNAs and PB1 mRNA binding sequences are not a perfect match, the miRNAs downregulate PB1 expression through mRNA degradation instead of translation repression. HVID00011974 Influenza A virus H1N1(H1N1) Homo sapiens Host miRNA hsa-mir-654(miR-654) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003676 MDCK cells - Virus mRNA PB1 http://www.ncbi.nlm.nih.gov/gene/956534 Downregulation Luciferase assay, Real-time reverse transcription-PCR analysis, HA assay, Western blot assay, Fluorescence microscopy. 20554777 The results showed that miRNA 323 (miR-323), miR-491, and miR-654 inhibit replication of the H1N1 influenza A virus through binding to the PB1 gene. Moreover mutational analysis of the predicted miRNA binding sites showed that the three miRNAs bind to the same conserved region of the PB1 gene. Intriguingly, despite the fact that the miRNAs and PB1 mRNA binding sequences are not a perfect match, the miRNAs downregulate PB1 expression through mRNA degradation instead of translation repression. HVID00011975 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-1258(hsa-miR-1258) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006392 - - Virus Protein RTA # Downregulation Bioinformatics and luciferase reporter analyses. 24554664 Bioinformatics and luciferase reporter analyses showed that one of the Nef-upregulated miRNAs, cellular miRNA 1258 (hsa-miR-1258), directly targeted a seed sequence in the 3' untranslated region (UTR) of the mRNA encoding the major lytic switch protein (RTA), which controls KSHV reactivation from latency. HVID00011976 Kaposi's sarcoma-associated herpesvirus(KSHV) Homo sapiens Host miRNA hsa-mir-1293( miR-1293) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006355 HEK293 and HeLa cells - Virus Protein K2(VIL-6) http://www.ncbi.nlm.nih.gov/gene/4961449 Downregulation Immunohistochemistry and Immunofluorescence, qRT-PCR, Transient cotransfection, ELISA, Western blot analysis. 21984125 We show a direct repression of vIL6 by hsa-miR-1293 and hIL6 by hsa-miR-608. The repression of vIL6 by miR-1293 was reversed by disruption of the vIL6 miR-1293 seed match through the introduction of point mutations. In addition, expression of vIL6 or hIL6 in KSHV-infected cells could be enhanced by transfection of the respective miRNA inhibitors. HVID00011977 Mink enteritis virus(MEV) Neovison vison Host miRNA miR-181b # feline kidney (F81) cell line Downregulation Virus mRNA NS1 # Downregulation Cell Culture. 24349084 Our study revealed that miRNA miR-181b inhibited replication of MEV in the feline kidney (F81) cell line by targeting the MEV non-structural protein 1 (NS1) messenger RNA (mRNA) coding region, resulting in NS1 translational repression, while MEV infection reduced miR-181b expression. HVID00011978 Primate foamy virus 1(PFV-1) Homo sapiens Host miRNA hsa-mir-32(miR-32) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0020490 293T cells Downregulation Virus Protein Tas # - Western and Northern analysis. 15845854 miR-32-mediated translational inhibition was indeed suppressed in Tas-expressing BHK21 cells. HVID00011979 Human respiratory syncytial virus(RSV) Homo sapiens Host miRNA hsa-let-7i(let-7i) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000434 Epithelial cells Upregulation Virus Protein NS1 http://www.ncbi.nlm.nih.gov/gene/1494468 - TaqMan real-time PCR, Immunoblotting, miRNA array. 23249809 Interestingly, we found that the RSV nonstructural genes NS1 and NS2 antagonized the upregulation of let-7i and miR-30b. RSV appears to manipulate host cell gene expression through regulation of expression of miRNAs related to the interferon response. The data suggest a new mechanism of virus-host cell interactions for paramyxoviruses. HVID00011980 Human respiratory syncytial virus(RSV) Homo sapiens Host miRNA hsa-mir-30b(miR-30b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000441 Epithelial cells Upregulation Virus Protein NS2 http://www.ncbi.nlm.nih.gov/gene/1489819 - TaqMan real-time PCR, Immunoblotting, miRNA array. 23249809 Interestingly, we found that the RSV nonstructural genes NS1 and NS2 antagonized the upregulation of let-7i and miR-30b. RSV appears to manipulate host cell gene expression through regulation of expression of miRNAs related to the interferon response. The data suggest a new mechanism of virus-host cell interactions for paramyxoviruses. HVID00011981 Simian immunodeficiency virus(SIV) Callithrix jacchus Host miRNA miR-146a - Macaque macrophages - Virus Protein nef(Nef) http://www.ncbi.nlm.nih.gov/gene/1490008 Downregulation Luciferase assays. 23988154 SIV RNA levels as well as Virus production was downregulated by direct targeting of the SIV Nef/U3 and R regions by four miRNAs. miRs-29a, -29b, -9 and -146a were induced in primary macrophages after SIV infection.Our data demonstrate that levels of primary transcripts and mature miRs-29a, -29b, -9 and -146a are modulated by SIV infection. We show that the SIV 3' UTR contains functional miRNA response elements (MREs) for all four miRNAs. Notably, these miRNAs regulate virus production and viral RNA levels in macrophages, the primary cells infected in the CNS that drive inflammation leading.to HIV-associated neurocognitive disorders. . HVID00011982 Simian immunodeficiency virus(SIV) Callithrix jacchus Host miRNA miR-29a - Macaque macrophages - Virus Protein nef(Nef) http://www.ncbi.nlm.nih.gov/gene/1490008 Downregulation Luciferase assays. 23988154 SIV RNA levels as well as Virus production was downregulated by direct targeting of the SIV Nef/U3 and R regions by four miRNAs. miRs-29a, -29b, -9 and -146a were induced in primary macrophages after SIV infection.Our data demonstrate that levels of primary transcripts and mature miRs-29a, -29b, -9 and -146a are modulated by SIV infection. We show that the SIV 3' UTR contains functional miRNA response elements (MREs) for all four miRNAs. Notably, these miRNAs regulate virus production and viral RNA levels in macrophages, the primary cells infected in the CNS that drive inflammation leading.to HIV-associated neurocognitive disorders. . HVID00011983 Simian immunodeficiency virus(SIV) Callithrix jacchus Host miRNA miR-29b - Macaque macrophages - Virus Protein nef(Nef) http://www.ncbi.nlm.nih.gov/gene/1490008 Downregulation Luciferase assays. 23988154 SIV RNA levels as well as Virus production was downregulated by direct targeting of the SIV Nef/U3 and R regions by four miRNAs. miRs-29a, -29b, -9 and -146a were induced in primary macrophages after SIV infection.Our data demonstrate that levels of primary transcripts and mature miRs-29a, -29b, -9 and -146a are modulated by SIV infection. We show that the SIV 3' UTR contains functional miRNA response elements (MREs) for all four miRNAs. Notably, these miRNAs regulate virus production and viral RNA levels in macrophages, the primary cells infected in the CNS that drive inflammation leading.to HIV-associated neurocognitive disorders. . HVID00011984 Simian immunodeficiency virus(SIV) Callithrix jacchus Host miRNA miR-9 - Macaque macrophages - Virus Protein nef(Nef) http://www.ncbi.nlm.nih.gov/gene/1490008 Downregulation Luciferase assays. 23988154 SIV RNA levels as well as Virus production was downregulated by direct targeting of the SIV Nef/U3 and R regions by four miRNAs. miRs-29a, -29b, -9 and -146a were induced in primary macrophages after SIV infection.Our data demonstrate that levels of primary transcripts and mature miRs-29a, -29b, -9 and -146a are modulated by SIV infection. We show that the SIV 3' UTR contains functional miRNA response elements (MREs) for all four miRNAs. Notably, these miRNAs regulate virus production and viral RNA levels in macrophages, the primary cells infected in the CNS that drive inflammation leading.to HIV-associated neurocognitive disorders. . HVID00011985 Simian virus 40(SV40) Homo sapiens Host miRNA hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 HeLa cells - Virus Protein SV40gp6(T antigen) http://www.ncbi.nlm.nih.gov/gene/1489531 Downregulation Fluorescence reporter assays. 22558366 Using the new reporter system, it was found that sv40-mir-S1-5p and hsa-miR423-5p downregulate the expression of common artificial target mRNAs and some predicted biological targets of hsa-miR423-5p, demonstrating that they are functional orthologs.These results demonstrated that SV40-encoded miRNA miR-S1-5p should act as a functional ortholog of the human-derived miRNA miR423-5p. SV40-encoded miR-S1-5p was reported to downregulate the expression of viral T antigen without reducing the yield of infectious virus,thus reducing host cytotoxic T lymphocyte (CTL) susceptibility and local cytokine release. . HVID00011986 Vesicular stomatitis virus(VSV) Mus musculus Host miRNA mmu-miR-24-3p(miR24) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000219 Dicer1(d/d) cells - Virus Protein L http://www.ncbi.nlm.nih.gov/gene/1489835 Downregulation - 17613256 Rather,we found that host miR24 and miR93 could target viral large protein(L protein) and phosphoprotein(P protein) genes, and a lack of miR24 and miR93 was responsible for increased VSV replication in Dicer1(d/d) cells. HVID00011987 Vesicular stomatitis virus(VSV) Mus musculus Host miRNA mmu-miR-24-3p(miR24) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000219 Dicer1(d/d) cells - Virus Protein P http://www.ncbi.nlm.nih.gov/gene/1489832 Downregulation - 17613256 Rather,we found that host miR24 and miR93 could target viral large protein(L protein) and phosphoprotein(P protein) genes, and a lack of miR24 and miR93 was responsible for increased VSV replication in Dicer2(d/d) cells. HVID00011988 Vesicular stomatitis virus(VSV) Mus musculus Host miRNA mmu-miR-93-5p (miR93) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000540 Dicer1(d/d) cells - Virus Protein L http://www.ncbi.nlm.nih.gov/gene/1489835 Downregulation - 17613256 Rather,we found that host miR24 and miR93 could target viral large protein(L protein) and phosphoprotein(P protein) genes, and a lack of miR24 and miR93 was responsible for increased VSV replication in Dicer1(d/d) cells. HVID00011989 Vesicular stomatitis virus(VSV) Mus musculus Host miRNA mmu-miR-93-5p (miR93) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000540 Dicer1(d/d) cells - Virus Protein P http://www.ncbi.nlm.nih.gov/gene/1489832 Downregulation - 17613256 Rather,we found that host miR24 and miR93 could target viral large protein(L protein) and phosphoprotein(P protein) genes, and a lack of miR24 and miR93 was responsible for increased VSV replication in Dicer2(d/d) cells. HVID00011990 White spot syndrome virus(WSSV) Litopenaeus vannamei Host miRNA lva-mir-7(miR-7) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0025136 - - Virus Protein Wsv477 http://www.ncbi.nlm.nih.gov/gene/926984 - Shrimp culture and shrimp infection by WSSV, Cell culture, transfection, and fluorescence assays, Northern blotting, Western blotting, Statistical analysis, Quantitative real-time PCR. 23015693 In this study, the results showed that shrimp miR-7 could target the 3'-untranslated region(3'UTR) of the WSSV early gene wsv477, implying that miR-7 was involved in viral DNA replication. In insect High Five cells, the synthesized miR-7 significantly decreased the expression level of the fluorescent construct bearing the 3=UTR of wsv477 compared with the expression of the control constructs. . VHID00011991 Hepatitis C virus(HCV) Homo sapiens Virus LncRNA vmr11 # human hepatocytes - Host Protein PTEN http://www.ncbi.nlm.nih.gov/gene/5728 Downregulation Real time Quantitative PCR, Subcellular protein fractionation and Western blot, Immunostaining 25075209 An HCV-derived small non-coding RNA inhibits Transportin-2 and PTEN translocation to the nucleus, suggesting a direct viral role in hepatic oncogenesis. VHID00011992 Hepatitis C virus(HCV) Homo sapiens Virus LncRNA vmr11 # Post-attachment primary human hepatocytes - Host Protein TNPO2(Transportin-2) http://www.ncbi.nlm.nih.gov/gene/30000 Downregulation Real time Quantitative PCR, Subcellular protein fractionation and Western blot, Immunostaining 25075209 An HCV-derived small non-coding RNA inhibits Transportin-2 and PTEN translocation to the nucleus, suggesting a direct viral role in hepatic oncogenesis. VHID00011993 Dengue virus(DENV) Homo sapiens Virus LncRNA sfRNA http://www.lncrnadb.org/Detail.aspx?TKeyID=225 HuH-7 hepatocellular carcinoma cells - Host Protein G3BP1 http://www.ncbi.nlm.nih.gov/gene/10146 Downregulation siRNA-mediated knockdown of gene expression, Polyribosome fractionation, ISRE-luciferase reporters 24992036 Their antiviral activity was antagonized by the abundant DENV-2 non-coding subgenomic flaviviral RNA(sfRNA), which bound to G3BP1, G3BP2 and CAPRIN1, inhibited their activity and lead to profound inhibition of ISG mRNA translation. VHID00011994 Dengue virus(DENV) Homo sapiens Virus LncRNA sfRNA http://www.lncrnadb.org/Detail.aspx?TKeyID=225 HuH-7 hepatocellular carcinoma cells - Host Protein G3BP2 http://www.ncbi.nlm.nih.gov/gene/9908 Downregulation siRNA-mediated knockdown of gene expression, Polyribosome fractionation, ISRE-luciferase reporters 24992036 Their antiviral activity was antagonized by the abundant DENV-2 non-coding subgenomic flaviviral RNA(sfRNA), which bound to G3BP1, G3BP2 and CAPRIN2, inhibited their activity and lead to profound inhibition of ISG mRNA translation. VHID00011995 Dengue virus(DENV) Homo sapiens Virus LncRNA sfRNA http://www.lncrnadb.org/Detail.aspx?TKeyID=225 HuH-7 hepatocellular carcinoma cells - Host Protein CAPRIN1 http://www.ncbi.nlm.nih.gov/gene/4076 Downregulation siRNA-mediated knockdown of gene expression, Polyribosome fractionation, ISRE-luciferase reporters 24992036 Their antiviral activity was antagonized by the abundant DENV-2 non-coding subgenomic flaviviral RNA(sfRNA), which bound to G3BP1, G3BP2 and CAPRIN3, inhibited their activity and lead to profound inhibition of ISG mRNA translation. VHID00011996 Dengue virus(DENV) Homo sapiens Virus LncRNA sfRNA http://www.lncrnadb.org/Detail.aspx?TKeyID=225 HuH-7 hepatocellular carcinoma cells - Host Protein IFIT3(ISG) http://www.ncbi.nlm.nih.gov/gene/3437 Downregulation siRNA-mediated knockdown of gene expression, Polyribosome fractionation, ISRE-luciferase reporters 24992036 Their antiviral activity was antagonized by the abundant DENV-2 non-coding subgenomic flaviviral RNA(sfRNA), which bound to G3BP1, G3BP2 and CAPRIN4, inhibited their activity and lead to profound inhibition of ISG mRNA translation. HHID00011997 Pseudorabies virus(PRV) Sus scrofa Host miRNA ssc-mir-21(miR-21) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002459 PRV-infected porcine kidney 15 cell line(PK-15) Upregulation Host Protein CXCL10(IP-10) http://www.ncbi.nlm.nih.gov/gene/494019 Downregulation miRNA microarray 24889251 In this study, we used miRNA microarray approaches to assess miRNA expression in PRV-infected porcine kidney 15 cell line(PK-15), and observed that miR-21 was expressed at high level 12h after the cells were infected with PRV. Furthermore, we identified chemokine(C-X-C motif) ligand 10(CXCL10), also named interferon-gamma inducible protein-10(IP-10), as a novel target gene of miR-21. IP-10 was down-regulated at 4h after PRV infection HVID00011998 Dengue virus(DENV) Aedes albopictus Host miRNA miR-252 # Ae. albopictus C6/36 cellline Upregulation Virus Protein E # Downregulation luciferase activity of a luciferase reporter 25025105 Transfection with miR-252 inhibitor resulted in the increase of DENV-2 RNA copies and the up-regulation of DENV-2 envelop protein(E protein) expression, whereas over expression of miR-252 with its mimic decreased DENV RNA copies and the down-regulation of E protein expression. HHID00011999 Bovine viral diarrhea virus(BVDV) Bovine Host miRNA bta-miR-29b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005043 Madin-Darby bovine kidney(MDBK) cells Upregulation Host mRNA CASP7(caspase-7) http://www.ncbi.nlm.nih.gov/gene/526279 Downregulation Dual-luciferase reporter assay, Real-time PCR, Western blots analysis, Flow cytometry analysis, Rescuing of caspase-7 and NAIF1 analysis, BVDV NADL replication analysis 24965127 We showed that miR-29b target sequences were present in the 3' untranslated regions of 2 key apoptosis regulators mRNAs, cysteine aspartases-7 (caspase-7) and nuclear apoptosis-inducing factor 1 (NAIF1). Indeed, upon miRNA overexpression, both mRNA and protein levels of caspase-7 and NAIF1 were decreased. We further found that miR-29b attenuated apoptosis by directly regulating intracellular levels of caspase-7 and NAIF1. Moreover, apoptosis blockage by miR-29b was rescued upon co-infection of MDBK cells with lentiviruses expressing caspase-7 and NAIF1. Importantly, miR-29b decreased BVDV NADL envelope glycoprotein E1 mRNA levels and suppressed viral replication. HHID00012000 Bovine viral diarrhea virus(BVDV) Bovine Host miRNA bta-miR-29b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005043 Madin-Darby bovine kidney(MDBK) cells Upregulation Host mRNA NAIF1 http://www.ncbi.nlm.nih.gov/gene/510689 Downregulation Dual-luciferase reporter assay, Real-time PCR, Western blots analysis, Flow cytometry analysis, Rescuing of caspase-7 and NAIF1 analysis, BVDV NADL replication analysis 24965127 We showed that miR-29b target sequences were present in the 3' untranslated regions of 2 key apoptosis regulators mRNAs, cysteine aspartases-7 (caspase-7) and nuclear apoptosis-inducing factor 1 (NAIF1). Indeed, upon miRNA overexpression, both mRNA and protein levels of caspase-7 and NAIF1 were decreased. We further found that miR-29b attenuated apoptosis by directly regulating intracellular levels of caspase-7 and NAIF1. Moreover, apoptosis blockage by miR-29b was rescued upon co-infection of MDBK cells with lentiviruses expressing caspase-7 and NAIF1. Importantly, miR-29b decreased BVDV NADL envelope glycoprotein E1 mRNA levels and suppressed viral replication. HVID00012001 Bovine viral diarrhea virus(BVDV) Bovine Host miRNA bta-miR-29b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005043 Madin-Darby bovine kidney(MDBK) cells Upregulation Virus mRNA PestiV1gp1(E1) http://www.ncbi.nlm.nih.gov/gene/1489735 Downregulation Dual-luciferase reporter assay, Real-time PCR, Western blots analysis, Flow cytometry analysis, Rescuing of caspase-7 and NAIF1 analysis, BVDV NADL replication analysis 24965127 We showed that miR-29b target sequences were present in the 3' untranslated regions of 2 key apoptosis regulators mRNAs, cysteine aspartases-7 (caspase-7) and nuclear apoptosis-inducing factor 1 (NAIF1). Indeed, upon miRNA overexpression, both mRNA and protein levels of caspase-7 and NAIF1 were decreased. We further found that miR-29b attenuated apoptosis by directly regulating intracellular levels of caspase-7 and NAIF1. Moreover, apoptosis blockage by miR-29b was rescued upon co-infection of MDBK cells with lentiviruses expressing caspase-7 and NAIF1. Importantly, miR-29b decreased BVDV NADL envelope glycoprotein E1 mRNA levels and suppressed viral replication. HVID00012002 Human papillomavirus(HPV) Homo sapiens Host LncRNA MALAT1 http://www.lncrnadb.org/Detail.aspx?TKeyID=93 CaSki cells Upregulate Virus Protein E7 http://www.ncbi.nlm.nih.gov/gene/?term=1489079 - RT-PCR, Cell proliferation assay, Cell cycle analysis, Wound healing assay 24932303 Of note, it was revealed that the expression of MALAT1 was decreased with the knockdown of HPV16 E6/E7 in CaSki cells. HVID00012003 Human papillomavirus(HPV) Homo sapiens Host LncRNA MALAT1 http://www.lncrnadb.org/Detail.aspx?TKeyID=93 CaSki cells Upregulate Virus Protein E6 http://www.ncbi.nlm.nih.gov/gene/?term=13887830 - RT-PCR, Cell proliferation assay, Cell cycle analysis, Wound healing assay 24932303 Of note, it was revealed that the expression of MALAT1 was decreased with the knockdown of HPV16 E6/E7 in CaSki cells. HVID00012004 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-581(miR-581) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003588 HepG2.2.15 cells Upregulation Virus Protein HBVgp2(HBsAg) http://www.ncbi.nlm.nih.gov/gene/944569 Upregualtion transfection 24913918 Altogether, we conclude that miR-581 promotes HBsAg expression by targeting Dicer and EDEM1. Our findings suggest that downregulation of miR-581 during hepatocarcinogenesis may lead to a reduction in HBsAg expression and impede HCC development. HHID00012005 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-581(miR-581) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003588 HepG2.2.15 cells Upregulation Host Protein DICER1(Dicer) http://www.ncbi.nlm.nih.gov/gene/23405 Upregualtion transfection 24913918 Altogether, we conclude that miR-581 promotes HBsAg expression by targeting Dicer and EDEM1. Our findings suggest that downregulation of miR-581 during hepatocarcinogenesis may lead to a reduction in HBsAg expression and impede HCC development. HHID00012006 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-581(miR-581) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003588 HepG2.2.15 cells Upregulation Host Protein EDEM1 http://www.ncbi.nlm.nih.gov/gene/9695 Upregualtion transfection 24913918 Altogether, we conclude that miR-581 promotes HBsAg expression by targeting Dicer and EDEM1. Our findings suggest that downregulation of miR-581 during hepatocarcinogenesis may lead to a reduction in HBsAg expression and impede HCC development. VVID00012007 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(miR-BART20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 AGS cell line Downregulation Virus Protein BZLF1 http://www.ncbi.nlm.nih.gov/gene/3783744 Upregualtion Bioinformatic analysis, luciferase reporter assay 24899173 In contrast, BZLF1 and BRLF1 expression in AGS-EBV cells transfected with a miR-BART20-5p inhibitor was enhanced. VVID00012008 Epstein-Barr virus(EBV) Homo sapiens Virus miRNA ebv-miR-BART20-5p(miR-BART20-5p) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003719 AGS cell line Downregulation Virus Protein BRLF1 http://www.ncbi.nlm.nih.gov/gene/3783727 Upregualtion Bioinformatic analysis, luciferase reporter assay 24899173 In contrast, BZLF1 and BRLF1 expression in AGS-EBV cells transfected with a miR-BART20-5p inhibitor was enhanced. HHID00012009 Porcine reproductive and respiratory syndrome virus(PRRSV) Sus scrofa Host miRNA miR-506 # MARC-145 cells Upregulation Host mRNA CD151 http://www.ncbi.nlm.nih.gov/gene/100511619 Downregulation luciferase reporter assay 24878990 Our results suggested that miR-506 could inhibit PRRSV replication by directly targeting PRRSV receptor of CD151 in MARC-145 cells. HHID00012010 Influenza A virus(infA) Mus musculus Host miRNA mmu-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000177 HEK-293T and MDCK cells Upregulation Host mRNA Socs1(SOCS1) http://www.ncbi.nlm.nih.gov/gene/12703 Downregulation qPCR and dual luciferase technology 24876306 Using qPCR and dual luciferase technology we show that miR-155 delivery resulted in a significant increase in cellular miR-155 which facilitated a downregulation of SOCS1 gene expression and a functional increase in IL-6 and IFN-beta cytokines. HHID00012011 Influenza A virus(infA) Mus musculus Host miRNA mmu-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000177 HEK-293T and MDCK cells Upregulation Host Protein Il6(IL-6) http://www.ncbi.nlm.nih.gov/gene/16193 Upregualtion qPCR and dual luciferase technology 24876306 Using qPCR and dual luciferase technology we show that miR-155 delivery resulted in a significant increase in cellular miR-155 which facilitated a downregulation of SOCS1 gene expression and a functional increase in IL-6 and IFN-beta cytokines. HHID00012012 Influenza A virus(infA) Mus musculus Host miRNA mmu-mir-155(miR-155) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000177 HEK-293T and MDCK cells Upregulation Host Protein Ifnb1(IFN-beta) http://www.ncbi.nlm.nih.gov/gene/15977 Upregualtion qPCR and dual luciferase technology 24876306 Using qPCR and dual luciferase technology we show that miR-155 delivery resulted in a significant increase in cellular miR-155 which facilitated a downregulation of SOCS1 gene expression and a functional increase in IL-6 and IFN-beta cytokines. HHID00012013 Simian immunodeficiency virus(SIV) Simian Host miRNA miR-190b # CD4(+) T cells Upregulation Host Protein MTMR6 # Downregulation Luciferase reporter assays 24981450 More importantly, miR-190b-mediated MTMR6 downregulation suggests an important mechanism that could keep infected cells in an activated state, thereby promoting viral replication. HHID00012014 Influenza A virus(infA) Homo sapiens Host miRNA hsa-mir-29c(miR-29c) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000735 A549 cells Upregulation Host Protein TNFAIP3(A20) http://www.ncbi.nlm.nih.gov/gene/7128 Upregualtion Luciferase reporter assays 24953694 Overexpression of miR-29c with miR-29c mimic enhanced IAV-induced A20 protein expression and conversely that miR-29c inhibitor significantly blocked IAV-induced A20 protein expression in A549 cells. HHID00012015 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-758(miR-758) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003757 liver cells Upregulation Host Protein TLR3 http://www.ncbi.nlm.nih.gov/gene/7098 Downregulation RT-PCR and luciferase reporter analysis 25008898 In conclusion, our results highlight the upregulation of miR-758 expression by HCV as a novel mechanism contributing to downregulation of TLR3 and TLR7 in patients with HCV infection. HHID00012016 Hepatitis C virus(HCV) Homo sapiens Host miRNA hsa-mir-758(miR-758) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003757 liver cells Upregulation Host Protein TLR7 http://www.ncbi.nlm.nih.gov/gene/51284 Downregulation RT-PCR and luciferase reporter analysis 25008898 In conclusion, our results highlight the upregulation of miR-758 expression by HCV as a novel mechanism contributing to downregulation of TLR3 and TLR7 in patients with HCV infection. HHID00012017 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-190a(miR-190) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000486 types I and III latency cells - Host mRNA NR4A3 http://www.ncbi.nlm.nih.gov/gene/8013 Downregulation microarray analysis 25086243 By targeting TP53INP1, miR-190 enhances cell survival by preventing apoptosis and relieving G0/G1 cell cycle arrest. Additionally, miR-190 down-regulates NR4A3, a cellular immediate-early gene for EBV reactivation, and inhibits the expression of the viral immediate-early gene bzlf1 and viral lytic DNA replication. HHID00012018 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-190a(miR-190) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000486 types I and III latency cells - Host mRNA TP53INP1 http://www.ncbi.nlm.nih.gov/gene/94241 Upregualtion microarray analysis 25086243 By targeting TP53INP1, miR-190 enhances cell survival by preventing apoptosis and relieving G0/G1 cell cycle arrest. Additionally, miR-190 down-regulates NR4A3, a cellular immediate-early gene for EBV reactivation, and inhibits the expression of the viral immediate-early gene bzlf1 and viral lytic DNA replication. HHID00012019 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-21(miR-21) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000077 MIHA cells Upregulation Host mRNA STAT3 http://www.ncbi.nlm.nih.gov/gene/6774 Upregualtion Luciferase reporter assays 25087183 Subsequently, we showed that the upregulation of miR-21 was mediated by HBx-induced interleukin-6 pathway followed by activation of STAT3 transcriptional factor. HHID00012020 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-31(miR-31) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000089 NPC cell line Downregulation Host mRNA FIH1 http://www.ncbi.nlm.nih.gov/gene/55662 - PCR and Quantitative RT-PCR, In situ hybridization(ISH) analysis, Bisulfite sequencing and Methylation specific-PCR(MSP) analysis, miR-31 mimic and siRNA transfection, Cell proliferation, colony formation and cell migration assays, Anchorage-independent growth and in vivo tumorigenicity assays, Luciferase reporter assay, Western blotting 25098679 Furthermore, we proved that miR-31 suppressed the NPC cell growth via targeting FIH1 and MCM2. HHID00012021 Epstein-Barr virus(EBV) Homo sapiens Host miRNA hsa-mir-31(miR-31) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000089 NPC cell line Downregulation Host mRNA MCM2 http://www.ncbi.nlm.nih.gov/gene/4171 - PCR and Quantitative RT-PCR, In situ hybridization(ISH) analysis, Bisulfite sequencing and Methylation specific-PCR(MSP) analysis, miR-31 mimic and siRNA transfection, Cell proliferation, colony formation and cell migration assays, Anchorage-independent growth and in vivo tumorigenicity assays, Luciferase reporter assay, Western blotting 25098679 Furthermore, we proved that miR-31 suppressed the NPC cell growth via targeting FIH1 and MCM2. HHID00012022 Dengue virus(DENV) Homo sapiens Host miRNA hsa-miR-30e-3p(miR-30e*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000693 human monocyte cell line U937 Upregulation Host mRNA OAS1 http://www.ncbi.nlm.nih.gov/gene/4938 Upregualtion Quantitative real-time PCR(qRT-PCR), Cell viability analysis, Transient transfection and luciferase assay, Western blot analysis and immunofluorescence assays 25122182 We found that DENV infection could induce miR-30e* expression in DENV-permissive cells, and such an overexpression of miR-30e* upregulated IFN-beta and the downstream IFN-stimulated genes(ISGs) such as OAS1, MxA and IFITM1, and suppressed DENV replication. HHID00012023 Dengue virus(DENV) Homo sapiens Host miRNA hsa-miR-30e-3p(miR-30e*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000693 human monocyte cell line U937 Upregulation Host mRNA MxA http://www.ncbi.nlm.nih.gov/gene/4599 Upregualtion Quantitative real-time PCR(qRT-PCR), Cell viability analysis, Transient transfection and luciferase assay, Western blot analysis and immunofluorescence assays 25122182 We found that DENV infection could induce miR-30e* expression in DENV-permissive cells, and such an overexpression of miR-30e* upregulated IFN-beta and the downstream IFN-stimulated genes(ISGs) such as OAS1, MxA and IFITM1, and suppressed DENV replication. HHID00012024 Dengue virus(DENV) Homo sapiens Host miRNA hsa-miR-30e-3p(miR-30e*) http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000693 human monocyte cell line U937 Upregulation Host mRNA IFITM1 http://www.ncbi.nlm.nih.gov/gene/8519 Upregualtion Quantitative real-time PCR(qRT-PCR), Cell viability analysis, Transient transfection and luciferase assay, Western blot analysis and immunofluorescence assays 25122182 We found that DENV infection could induce miR-30e* expression in DENV-permissive cells, and such an overexpression of miR-30e* upregulated IFN-beta and the downstream IFN-stimulated genes(ISGs) such as OAS1, MxA and IFITM1, and suppressed DENV replication. HHID00012025 Hepatitis B virus(HBV) Homo sapiens Host miRNA hsa-mir-125b(miR-125b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000446 HepG2-HBV1.3 and HepG2.2.15 cells - Host mRNA SCNN1A http://www.ncbi.nlm.nih.gov/gene/6337 Downregulation dual luciferase reporter 25173609 miR-125b also inhibited the mRNA and protein levels of SCNN1A. HVID00012026 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr10:106370573-106373008 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downregulated by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012027 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr10:115824453-115826586 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downregulated by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012028 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr10:12927523-12929693 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012029 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr11:119004357-119007259 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012030 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr11:18367483-18393258 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012031 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr1:135599257-135601738 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012032 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr1:158734297-158736426 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012033 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr11:59011295-59015887 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012034 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr11:85580335-85589555 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012035 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr12:25645522-25649259 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012036 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr12:77433374-77435129 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012037 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr12:8518007-8569487 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012038 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr13:115743308-115745940 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012039 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr15:100430635-100433197 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012040 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr15:82184918-82188766 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012041 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr17:27372020-27385011 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012042 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr17:31075815-31077651 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012043 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr17:47006033-47023558 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012044 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr18:68419148-68420202 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012045 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr19:24039631-24042105 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012046 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr2:147831590-147834197 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012047 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr2:16675375-16677465 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012048 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr3:137578389-137579521 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012049 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr4:100825987-100829372 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012050 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr4:153651617-153654706 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012051 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr4:154011685-154018825 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012052 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr5:109278803-109287241 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012053 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr5:136147293-136162818 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012054 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr5:25005759-25008367 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012055 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr6:140554415-140560315 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012056 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr6:84562231-84565133 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012057 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr6:92890327-93222971 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012058 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr7:56377704-56415189 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012059 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr7:87236516-87239059 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012060 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr8:70711235-70721660 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012061 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr8:75072315-75075582 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012062 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr9:3900746-3904016 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012063 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr9:3904399-3905785 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012064 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr9:67414463-67483185 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012065 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr10:60892008-60893694 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012066 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr10:62262341-62269871 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012067 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr10:83325890-83402790 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012068 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr11:102983499-102994239 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012069 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr11:119322515-119352549 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012070 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr1:11290241-11293554 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012071 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr11:30183310-30193505 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012072 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr11:48603904-48611829 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012073 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr11:69184157-69201732 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012074 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr12:100032658-100035279 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012075 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr12:103508601-103510701 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012076 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr12:45415566-45423476 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012077 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr12:59361747-59364435 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012078 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr13:108825897-108834311 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012079 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr13:23517278-23523756 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012080 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr13:24999460-25001763 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012081 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr13:49063549-49067402 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012082 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr13:94182877-94203852 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012083 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr14:17832997-17838422 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012084 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr14:22808967-22810356 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012085 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr14:51508265-51510242 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012086 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr14:67585234-67596823 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012087 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr1:51796224-51804149 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012088 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr15:37161555-37162896 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012089 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr15:79158057-79159144 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012090 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr15:81073090-81082292 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012091 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr16:4284889-4286151 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012092 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr17:21653417-21672842 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012093 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr1:72680343-72682229 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012094 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr17:31073947-31074476 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012095 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr17:63395303-63398520 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012096 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr18:11003686-11048675 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012097 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr1:82445004-82446218 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012098 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr18:36449530-36456800 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012099 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr18:55149964-55239068 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012100 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr19:40942806-40957129 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012101 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr19:44653018-44654777 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012102 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr19:56675526-56677992 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012103 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr1:98768798-98777807 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012104 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr2:12222652-12233942 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012105 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr2:132079093-132086642 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012106 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr2:164376030-164385230 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012107 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr2:84913771-84934718 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012108 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr2:92581668-92618534 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012109 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr3:102579388-102583783 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012110 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr3:102810059-102812375 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012111 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr3:85775329-85884359 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012112 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr3:87834800-87837072 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012113 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr3:88394620-88412470 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012114 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr3:97066278-97069569 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012115 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr3:97088831-97101701 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012116 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr4:104701771-104703792 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012117 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr4:11893712-11931875 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012118 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr4:154020159-154031159 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012119 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr4:20038233-20042502 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012120 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr4:40667092-40669900 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012121 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr4:53259068-53263987 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012122 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr4:82156098-82196298 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012123 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr5:113594167-113645342 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012124 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr5:120020142-120077391 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012125 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr5:123590337-123590983 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012126 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr5:149751979-149827389 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012127 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr5:53364251-53385674 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012128 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr5:53931541-53945241 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012129 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr5:54296404-54300455 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012130 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr5:91232287-91235418 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012131 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr6:115568814-115571700 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012132 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr6:118537258-118542312 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012133 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr6:30752887-30758830 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012134 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr6:88874003-88884403 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012135 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr6:90833815-90845065 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012136 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr6:90915489-90940052 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012137 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr7:105830846-105851438 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012138 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr7:133021933-133023852 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012139 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr7:63228889-63230212 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012140 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr7:77561248-77568373 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012141 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr7:88668948-88677948 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012142 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr8:10899922-10903874 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012143 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr8:122733358-123011458 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012144 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr8:13200730-13207713 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012145 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr8:42102822-42109808 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012146 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr8:4527036-4529608 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012147 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr8:70601735-70611660 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012148 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr8:71689644-71708114 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012149 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr9:109992261-109994962 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012150 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr9:121665758-121669061 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012151 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr9:14135885-14137545 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012152 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr9:43525339-43544496 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012153 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr9:96222407-96224058 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012154 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chrX:12624343-12643975 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012155 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chrX:148720661-148763177 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012156 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chrX:155824149-155827544 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012157 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr16:30021928-30039565 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012158 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr2:31803025-31804603 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012159 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr6:5169082-5170486 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Downregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012160 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr10:16670901-16815588 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012161 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr10:37057292-37099458 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012162 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr10:69654781-69655946 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012163 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr10:96096971-96113171 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012164 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr11:102819623-102825468 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012165 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr11:117835680-117842574 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012166 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr11:119250824-119286324 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012167 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr1:134237581-134248506 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012168 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr1:162965309-162970704 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012169 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr11:6421951-6429173 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012170 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr11:75275041-75280192 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012171 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr1:175350729-175389850 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012172 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr1:175496415-175510531 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012173 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr11:76400207-76435704 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012174 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr1:196801966-196864099 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012175 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr13:15905381-16115256 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012176 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr13:37871609-37873311 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012177 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr13:99777054-99791650 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012178 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr15:77164450-77201440 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012179 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr16:25013537-25021162 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012180 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr16:84713277-84715489 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012181 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr16:91044901-91056922 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012182 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr17:27703181-27716306 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012183 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr17:79249845-79251884 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012184 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr18:35713064-35717970 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012185 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr18:38957062-38965037 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012186 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr19:11566538-11582584 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012187 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr19:46388591-46389863 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012188 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr2:11261116-11265733 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012189 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr2:126716138-126719837 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012190 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr2:148340274-148351561 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012191 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr2:155651881-155654616 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012192 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr2:180322370-180324419 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012193 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr4:139175321-139176295 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012194 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr4:141441569-141453196 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012195 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr6:134183176-134193729 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012196 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr6:51542766-51562891 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012197 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr6:86477309-86537554 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012198 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr7:105550493-105568318 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012199 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr7:82902248-82955248 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012200 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr9:56108126-56265814 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012201 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chrX:49983775-50002675 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012202 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr1:107866276-107887102 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012203 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr11:53592946-53637922 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012204 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr11:86394703-86395196 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012205 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr12:10453194-10538109 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012206 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr13:16120653-16123440 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012207 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr16:25039487-25069144 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012208 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr16:84702353-84710928 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012209 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr17:79281382-79291840 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012210 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr17:84470764-84486339 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012211 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr18:60792135-60831035 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012212 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr18:61694966-61696115 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012213 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr19:12592405-12671056 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012214 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr2:117940123-117951453 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012215 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr2:167653193-167659146 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012216 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr3:65730011-65744189 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012217 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr3:7612705-7690001 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012218 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr3:95469971-95478000 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012219 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr3:95493525-95508668 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012220 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr4:6279252-6284677 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012221 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr6:134934743-134936836 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012222 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr6:3283194-3296069 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012223 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr6:39013878-39017585 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012224 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr7:128206366-128207459 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012225 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr7:3221916-3228537 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012226 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr8:129336540-129400338 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012227 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr8:75016833-75029398 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012228 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr8:93340044-93341253 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012229 Severe acute respiratory syndrome coronavirus(SARS-CoV) Mus musculus Host LncRNA chr9:65368913-65390480 - mouse-adapted strain MA15 that is lethal in BALB/c mice and that causes 10 to 15% weight loss in young C56BL/6 mice Upregulation - - - # - Sequencing and read mapping, Quantitative real-time PCR, Sequencing and read mapping, ncRNA annotations and the estimation of expression levels. 20978541 We found that 509 of these loci were differentially expressed during SARS-CoV MA15 infection (Fig. 3), 485 of which had more than 2.5-fold change in at least one of four mouse strains during infection, and 209 of which were all upregulated or all downreguted by at least 1.8-fold in three or more mouse strains (see Tables S2 and S3 in the supplemental material). HVID00012230 Reconstructed 1918 influenza virus(r1918) Mus musculus Host miRNA mmu-let-7e(Let-7e) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000561 mice lung cells Downregulation - - - # - RNA isolation, MicroRNA microarray analysis, Quantitative real-time PCR, mRNA microarray analysis 20071585 Table 1; We found that a group of microRNAs, including miR-200a and miR-223, were differentially expressed in response to influenza virus infection and that r1918 and A/Texas/36/91 infection induced distinct microRNA expression profiles. HVID00012231 Reconstructed 1918 influenza virus(r1918) Mus musculus Host miRNA mmu-let-7f-1(Let-7f) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000562 mice lung cells Downregulation - - - # - RNA isolation, MicroRNA microarray analysis, Quantitative real-time PCR, mRNA microarray analysis 20071585 Table 1; We found that a group of microRNAs, including miR-200a and miR-223, were differentially expressed in response to influenza virus infection and that r1918 and A/Texas/36/91 infection induced distinct microRNA expression profiles. HVID00012232 Reconstructed 1918 influenza virus(r1918) Mus musculus Host miRNA mmu-mir-145a(miR-145) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000169 mice lung cells Downregulation - - - # - RNA isolation, MicroRNA microarray analysis, Quantitative real-time PCR, mRNA microarray analysis 20071585 Table 1; We found that a group of microRNAs, including miR-200a and miR-223, were differentially expressed in response to influenza virus infection and that r1918 and A/Texas/36/91 infection induced distinct microRNA expression profiles. HVID00012233 Reconstructed 1918 influenza virus(r1918) Mus musculus Host miRNA mmu-mir-193a(miR-193) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000235 mice lung cells Downregulation - - - # - RNA isolation, MicroRNA microarray analysis, Quantitative real-time PCR, mRNA microarray analysis 20071585 Table 1; We found that a group of microRNAs, including miR-200a and miR-223, were differentially expressed in response to influenza virus infection and that r1918 and A/Texas/36/91 infection induced distinct microRNA expression profiles. HVID00012234 Reconstructed 1918 influenza virus(r1918) Mus musculus Host miRNA mmu-mir-200a(miR-200a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000554 mice lung cells Downregulation - - - # - RNA isolation, MicroRNA microarray analysis, Quantitative real-time PCR, mRNA microarray analysis 20071585 Table 1; We found that a group of microRNAs, including miR-200a and miR-223, were differentially expressed in response to influenza virus infection and that r1918 and A/Texas/36/91 infection induced distinct microRNA expression profiles. HVID00012235 Reconstructed 1918 influenza virus(r1918) Mus musculus Host miRNA mmu-mir-200b(miR-200b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000243 mice lung cells Downregulation - - - # - RNA isolation, MicroRNA microarray analysis, Quantitative real-time PCR, mRNA microarray analysis 20071585 Table 1; We found that a group of microRNAs, including miR-200a and miR-223, were differentially expressed in response to influenza virus infection and that r1918 and A/Texas/36/91 infection induced distinct microRNA expression profiles. HVID00012236 Reconstructed 1918 influenza virus(r1918) Mus musculus Host miRNA mmu-mir-21a(miR-21) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000569 mice lung cells Upregulation - - - # - RNA isolation, MicroRNA microarray analysis, Quantitative real-time PCR, mRNA microarray analysis 20071585 Table 1; We found that a group of microRNAs, including miR-200a and miR-223, were differentially expressed in response to influenza virus infection and that r1918 and A/Texas/36/91 infection induced distinct microRNA expression profiles. HVID00012237 Reconstructed 1918 influenza virus(r1918) Mus musculus Host miRNA mmu-mir-223(miR-223) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000703 mice lung cells Upregulation - - - # - RNA isolation, MicroRNA microarray analysis, Quantitative real-time PCR, mRNA microarray analysis 20071585 Table 1; We found that a group of microRNAs, including miR-200a and miR-223, were differentially expressed in response to influenza virus infection and that r1918 and A/Texas/36/91 infection induced distinct microRNA expression profiles. HVID00012238 Reconstructed 1918 influenza virus(r1918) Mus musculus Host miRNA mmu-mir-27a(miR-27a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000578 mice lung cells Downregulation - - - # - RNA isolation, MicroRNA microarray analysis, Quantitative real-time PCR, mRNA microarray analysis 20071585 Table 1; We found that a group of microRNAs, including miR-200a and miR-223, were differentially expressed in response to influenza virus infection and that r1918 and A/Texas/36/91 infection induced distinct microRNA expression profiles. HVID00012239 Reconstructed 1918 influenza virus(r1918) Mus musculus Host miRNA mmu-mir-27b(miR-27b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000142 mice lung cells Downregulation - - - # - RNA isolation, MicroRNA microarray analysis, Quantitative real-time PCR, mRNA microarray analysis 20071585 Table 1; We found that a group of microRNAs, including miR-200a and miR-223, were differentially expressed in response to influenza virus infection and that r1918 and A/Texas/36/91 infection induced distinct microRNA expression profiles. HVID00012240 Reconstructed 1918 influenza virus(r1918) Mus musculus Host miRNA mmu-mir-29a(miR-29a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000576 mice lung cells Downregulation - - - # - RNA isolation, MicroRNA microarray analysis, Quantitative real-time PCR, mRNA microarray analysis 20071585 Table 1; We found that a group of microRNAs, including miR-200a and miR-223, were differentially expressed in response to influenza virus infection and that r1918 and A/Texas/36/91 infection induced distinct microRNA expression profiles. HVID00012241 Reconstructed 1918 influenza virus(r1918) Mus musculus Host miRNA mmu-mir-29b-1(miR-29b) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000143 mice lung cells Downregulation - - - # - RNA isolation, MicroRNA microarray analysis, Quantitative real-time PCR, mRNA microarray analysis 20071585 Table 1; We found that a group of microRNAs, including miR-200a and miR-223, were differentially expressed in response to influenza virus infection and that r1918 and A/Texas/36/91 infection induced distinct microRNA expression profiles. HVID00012242 Reconstructed 1918 influenza virus(r1918) Mus musculus Host miRNA mmu-mir-30a(miR-30a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000144 mice lung cells Downregulation - - - # - RNA isolation, MicroRNA microarray analysis, Quantitative real-time PCR, mRNA microarray analysis 20071585 Table 1; We found that a group of microRNAs, including miR-200a and miR-223, were differentially expressed in response to influenza virus infection and that r1918 and A/Texas/36/91 infection induced distinct microRNA expression profiles. HVID00012243 Reconstructed 1918 influenza virus(r1918) Mus musculus Host miRNA mmu-mir-30d(miR-30d) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000549 mice lung cells Downregulation - - - # - RNA isolation, MicroRNA microarray analysis, Quantitative real-time PCR, mRNA microarray analysis 20071585 Table 1; We found that a group of microRNAs, including miR-200a and miR-223, were differentially expressed in response to influenza virus infection and that r1918 and A/Texas/36/91 infection induced distinct microRNA expression profiles. HVID00012244 Reconstructed 1918 influenza virus(r1918) Mus musculus Host miRNA mmu-mir-34a(miR-34a) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000584 mice lung cells Downregulation - - - # - RNA isolation, MicroRNA microarray analysis, Quantitative real-time PCR, mRNA microarray analysis 20071585 Table 1; We found that a group of microRNAs, including miR-200a and miR-223, were differentially expressed in response to influenza virus infection and that r1918 and A/Texas/36/91 infection induced distinct microRNA expression profiles. HVID00012245 Reconstructed 1918 influenza virus(r1918) Mus musculus Host miRNA mmu-mir-429(miR-429) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001642 mice lung cells Downregulation - - - # - RNA isolation, MicroRNA microarray analysis, Quantitative real-time PCR, mRNA microarray analysis 20071585 Table 1; We found that a group of microRNAs, including miR-200a and miR-223, were differentially expressed in response to influenza virus infection and that r1918 and A/Texas/36/91 infection induced distinct microRNA expression profiles. HVID00012246 Reconstructed 1918 influenza virus(r1918) Mus musculus Host miRNA mmu-mir-652(miR-652) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004965 mice lung cells Downregulation - - - # - RNA isolation, MicroRNA microarray analysis, Quantitative real-time PCR, mRNA microarray analysis 20071585 Table 1; We found that a group of microRNAs, including miR-200a and miR-223, were differentially expressed in response to influenza virus infection and that r1918 and A/Texas/36/91 infection induced distinct microRNA expression profiles. HVID00012247 Reconstructed 1918 influenza virus(r1918) Mus musculus Host miRNA mmu-mir-709(miR-709) http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0004693 mice lung cells Upregulation - - - # - RNA isolation, MicroRNA microarray analysis, Quantitative real-time PCR, mRNA microarray analysis 20071585 Table 1; We found that a group of microRNAs, including miR-200a and miR-223, were differentially expressed in response to influenza virus infection and that r1918 and A/Texas/36/91 infection induced distinct microRNA expression profiles.